-- dump date 20140620_080303 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1194526000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1194526000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1194526000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526000004 Walker A motif; other site 1194526000005 ATP binding site [chemical binding]; other site 1194526000006 Walker B motif; other site 1194526000007 arginine finger; other site 1194526000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1194526000009 DnaA box-binding interface [nucleotide binding]; other site 1194526000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1194526000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1194526000012 putative DNA binding surface [nucleotide binding]; other site 1194526000013 dimer interface [polypeptide binding]; other site 1194526000014 beta-clamp/clamp loader binding surface; other site 1194526000015 beta-clamp/translesion DNA polymerase binding surface; other site 1194526000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1194526000017 recombination protein F; Reviewed; Region: recF; PRK00064 1194526000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1194526000019 Walker A/P-loop; other site 1194526000020 ATP binding site [chemical binding]; other site 1194526000021 Q-loop/lid; other site 1194526000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526000023 ABC transporter signature motif; other site 1194526000024 Walker B; other site 1194526000025 D-loop; other site 1194526000026 H-loop/switch region; other site 1194526000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1194526000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526000029 Mg2+ binding site [ion binding]; other site 1194526000030 G-X-G motif; other site 1194526000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1194526000032 anchoring element; other site 1194526000033 dimer interface [polypeptide binding]; other site 1194526000034 ATP binding site [chemical binding]; other site 1194526000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1194526000036 active site 1194526000037 putative metal-binding site [ion binding]; other site 1194526000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1194526000039 DNA gyrase subunit A; Validated; Region: PRK05560 1194526000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1194526000041 CAP-like domain; other site 1194526000042 active site 1194526000043 primary dimer interface [polypeptide binding]; other site 1194526000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1194526000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1194526000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1194526000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1194526000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1194526000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1194526000050 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1194526000051 putative substrate binding site [chemical binding]; other site 1194526000052 putative ATP binding site [chemical binding]; other site 1194526000053 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1194526000054 active sites [active] 1194526000055 tetramer interface [polypeptide binding]; other site 1194526000056 seryl-tRNA synthetase; Provisional; Region: PRK05431 1194526000057 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1194526000058 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1194526000059 dimer interface [polypeptide binding]; other site 1194526000060 active site 1194526000061 motif 1; other site 1194526000062 motif 2; other site 1194526000063 motif 3; other site 1194526000064 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1194526000065 Predicted membrane protein [Function unknown]; Region: COG4392 1194526000066 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1194526000067 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1194526000068 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1194526000069 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1194526000070 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1194526000071 DHH family; Region: DHH; pfam01368 1194526000072 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1194526000073 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1194526000074 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1194526000075 replicative DNA helicase; Region: DnaB; TIGR00665 1194526000076 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1194526000077 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1194526000078 Walker A motif; other site 1194526000079 ATP binding site [chemical binding]; other site 1194526000080 Walker B motif; other site 1194526000081 DNA binding loops [nucleotide binding] 1194526000082 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1194526000083 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1194526000084 GDP-binding site [chemical binding]; other site 1194526000085 ACT binding site; other site 1194526000086 IMP binding site; other site 1194526000087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1194526000088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526000089 active site 1194526000090 phosphorylation site [posttranslational modification] 1194526000091 intermolecular recognition site; other site 1194526000092 dimerization interface [polypeptide binding]; other site 1194526000093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1194526000094 DNA binding site [nucleotide binding] 1194526000095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1194526000096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1194526000097 dimerization interface [polypeptide binding]; other site 1194526000098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1194526000099 putative active site [active] 1194526000100 heme pocket [chemical binding]; other site 1194526000101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1194526000102 dimer interface [polypeptide binding]; other site 1194526000103 phosphorylation site [posttranslational modification] 1194526000104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526000105 ATP binding site [chemical binding]; other site 1194526000106 Mg2+ binding site [ion binding]; other site 1194526000107 G-X-G motif; other site 1194526000108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1194526000109 YycH protein; Region: YycH; pfam07435 1194526000110 YycH protein; Region: YycI; cl02015 1194526000111 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1194526000112 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1194526000113 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1194526000114 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1194526000115 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1194526000116 Walker A motif; other site 1194526000117 ATP binding site [chemical binding]; other site 1194526000118 Walker B motif; other site 1194526000119 arginine finger; other site 1194526000120 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1194526000121 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1194526000122 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1194526000123 FMN binding site [chemical binding]; other site 1194526000124 active site 1194526000125 catalytic residues [active] 1194526000126 substrate binding site [chemical binding]; other site 1194526000127 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1194526000128 Family description; Region: UvrD_C_2; pfam13538 1194526000129 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1194526000130 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1194526000131 active site 1194526000132 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1194526000133 non-prolyl cis peptide bond; other site 1194526000134 Predicted transcriptional regulators [Transcription]; Region: COG1733 1194526000135 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1194526000136 dimerization interface [polypeptide binding]; other site 1194526000137 putative Zn2+ binding site [ion binding]; other site 1194526000138 putative DNA binding site [nucleotide binding]; other site 1194526000139 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1194526000140 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1194526000141 FMN binding site [chemical binding]; other site 1194526000142 substrate binding site [chemical binding]; other site 1194526000143 putative catalytic residue [active] 1194526000144 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1194526000145 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1194526000146 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1194526000147 Double zinc ribbon; Region: DZR; pfam12773 1194526000148 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1194526000149 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1194526000150 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1194526000151 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1194526000152 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1194526000153 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1194526000154 Citrate transporter; Region: CitMHS; pfam03600 1194526000155 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1194526000156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526000158 putative substrate translocation pore; other site 1194526000159 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1194526000160 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1194526000161 metal binding site [ion binding]; metal-binding site 1194526000162 dimer interface [polypeptide binding]; other site 1194526000163 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1194526000164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526000165 S-adenosylmethionine binding site [chemical binding]; other site 1194526000166 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 1194526000167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1194526000168 Helix-turn-helix domain; Region: HTH_18; pfam12833 1194526000169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1194526000170 hypothetical protein; Provisional; Region: PRK02399 1194526000171 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1194526000172 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1194526000173 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1194526000174 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1194526000175 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1194526000176 maltose O-acetyltransferase; Provisional; Region: PRK10092 1194526000177 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1194526000178 active site 1194526000179 substrate binding site [chemical binding]; other site 1194526000180 trimer interface [polypeptide binding]; other site 1194526000181 CoA binding site [chemical binding]; other site 1194526000182 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1194526000183 benzoate transport; Region: 2A0115; TIGR00895 1194526000184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000185 putative substrate translocation pore; other site 1194526000186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000187 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1194526000188 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1194526000189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526000190 AsnC family; Region: AsnC_trans_reg; pfam01037 1194526000191 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1194526000192 SnoaL-like domain; Region: SnoaL_4; pfam13577 1194526000193 Amidohydrolase; Region: Amidohydro_2; pfam04909 1194526000194 FAD binding domain; Region: FAD_binding_3; pfam01494 1194526000195 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1194526000196 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1194526000197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1194526000198 DNA binding site [nucleotide binding] 1194526000199 domain linker motif; other site 1194526000200 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1194526000201 dimerization interface [polypeptide binding]; other site 1194526000202 ligand binding site [chemical binding]; other site 1194526000203 Sugar transport protein; Region: Sugar_transport; pfam06800 1194526000204 D-ribose pyranase; Provisional; Region: PRK11797 1194526000205 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1194526000206 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1194526000207 substrate binding site [chemical binding]; other site 1194526000208 dimer interface [polypeptide binding]; other site 1194526000209 ATP binding site [chemical binding]; other site 1194526000210 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1194526000211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1194526000212 active site 1194526000213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000214 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526000215 putative substrate translocation pore; other site 1194526000216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000217 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1194526000218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526000219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526000220 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1194526000221 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1194526000222 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1194526000223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526000224 Walker A/P-loop; other site 1194526000225 ATP binding site [chemical binding]; other site 1194526000226 Q-loop/lid; other site 1194526000227 ABC transporter signature motif; other site 1194526000228 Walker B; other site 1194526000229 D-loop; other site 1194526000230 H-loop/switch region; other site 1194526000231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526000232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526000233 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1194526000234 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1194526000235 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1194526000236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1194526000237 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1194526000238 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1194526000239 substrate binding site [chemical binding]; other site 1194526000240 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1194526000241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526000242 dimer interface [polypeptide binding]; other site 1194526000243 conserved gate region; other site 1194526000244 putative PBP binding loops; other site 1194526000245 ABC-ATPase subunit interface; other site 1194526000246 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1194526000247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526000248 dimer interface [polypeptide binding]; other site 1194526000249 conserved gate region; other site 1194526000250 putative PBP binding loops; other site 1194526000251 ABC-ATPase subunit interface; other site 1194526000252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1194526000253 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1194526000254 Walker A/P-loop; other site 1194526000255 ATP binding site [chemical binding]; other site 1194526000256 Q-loop/lid; other site 1194526000257 ABC transporter signature motif; other site 1194526000258 Walker B; other site 1194526000259 D-loop; other site 1194526000260 H-loop/switch region; other site 1194526000261 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1194526000262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1194526000263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1194526000264 Walker A/P-loop; other site 1194526000265 ATP binding site [chemical binding]; other site 1194526000266 Q-loop/lid; other site 1194526000267 ABC transporter signature motif; other site 1194526000268 Walker B; other site 1194526000269 D-loop; other site 1194526000270 H-loop/switch region; other site 1194526000271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526000273 putative substrate translocation pore; other site 1194526000274 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1194526000275 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1194526000276 Zn binding site [ion binding]; other site 1194526000277 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1194526000278 Zn binding site [ion binding]; other site 1194526000279 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1194526000280 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1194526000281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1194526000282 ATP binding site [chemical binding]; other site 1194526000283 putative Mg++ binding site [ion binding]; other site 1194526000284 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1194526000285 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1194526000286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526000287 S-adenosylmethionine binding site [chemical binding]; other site 1194526000288 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1194526000289 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1194526000290 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1194526000291 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1194526000292 Predicted transcriptional regulators [Transcription]; Region: COG1733 1194526000293 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1194526000294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526000295 Walker A/P-loop; other site 1194526000296 ATP binding site [chemical binding]; other site 1194526000297 Q-loop/lid; other site 1194526000298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526000299 ABC transporter signature motif; other site 1194526000300 Walker B; other site 1194526000301 D-loop; other site 1194526000302 H-loop/switch region; other site 1194526000303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526000304 AAA domain; Region: AAA_21; pfam13304 1194526000305 Walker A/P-loop; other site 1194526000306 ATP binding site [chemical binding]; other site 1194526000307 Q-loop/lid; other site 1194526000308 ABC transporter signature motif; other site 1194526000309 Walker B; other site 1194526000310 D-loop; other site 1194526000311 H-loop/switch region; other site 1194526000312 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1194526000313 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1194526000314 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1194526000315 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1194526000316 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1194526000317 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1194526000318 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1194526000319 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1194526000320 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1194526000321 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1194526000322 active site 1194526000323 dimer interface [polypeptide binding]; other site 1194526000324 magnesium binding site [ion binding]; other site 1194526000325 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1194526000326 tetramer interface [polypeptide binding]; other site 1194526000327 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1194526000328 active site 1194526000329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526000330 Integrase core domain; Region: rve; pfam00665 1194526000331 Predicted membrane protein [Function unknown]; Region: COG2855 1194526000332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526000333 Integrase core domain; Region: rve; pfam00665 1194526000334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1194526000335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1194526000336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1194526000337 dimerization interface [polypeptide binding]; other site 1194526000338 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 1194526000339 Integral membrane protein DUF95; Region: DUF95; pfam01944 1194526000340 SdpI/YhfL protein family; Region: SdpI; pfam13630 1194526000341 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1194526000342 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1194526000343 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1194526000344 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1194526000345 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1194526000346 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1194526000347 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1194526000348 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1194526000349 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1194526000350 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1194526000351 ligand binding site [chemical binding]; other site 1194526000352 flexible hinge region; other site 1194526000353 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1194526000354 carbamate kinase; Reviewed; Region: PRK12686 1194526000355 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1194526000356 putative substrate binding site [chemical binding]; other site 1194526000357 nucleotide binding site [chemical binding]; other site 1194526000358 nucleotide binding site [chemical binding]; other site 1194526000359 homodimer interface [polypeptide binding]; other site 1194526000360 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1194526000361 ornithine carbamoyltransferase; Validated; Region: PRK02102 1194526000362 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1194526000363 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1194526000364 arginine deiminase; Provisional; Region: PRK01388 1194526000365 Arginine repressor [Transcription]; Region: ArgR; COG1438 1194526000366 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1194526000367 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1194526000368 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1194526000369 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1194526000370 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1194526000371 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1194526000372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526000373 Coenzyme A binding pocket [chemical binding]; other site 1194526000374 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 1194526000375 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1194526000376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526000377 motif II; other site 1194526000378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526000380 putative substrate translocation pore; other site 1194526000381 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 1194526000382 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1194526000383 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1194526000384 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1194526000385 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1194526000386 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 1194526000387 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1194526000388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1194526000389 nucleotide binding region [chemical binding]; other site 1194526000390 ATP-binding site [chemical binding]; other site 1194526000391 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1194526000392 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1194526000393 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1194526000394 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1194526000395 SecY translocase; Region: SecY; pfam00344 1194526000396 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1194526000397 legume lectins; Region: lectin_L-type; cd01951 1194526000398 homotetramer interaction site [polypeptide binding]; other site 1194526000399 carbohydrate binding site [chemical binding]; other site 1194526000400 metal binding site [ion binding]; metal-binding site 1194526000401 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1194526000402 Putative Ig domain; Region: He_PIG; pfam05345 1194526000403 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1194526000404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526000405 S-adenosylmethionine binding site [chemical binding]; other site 1194526000406 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1194526000407 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1194526000408 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1194526000409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526000410 dimer interface [polypeptide binding]; other site 1194526000411 conserved gate region; other site 1194526000412 putative PBP binding loops; other site 1194526000413 ABC-ATPase subunit interface; other site 1194526000414 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1194526000415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1194526000416 dimer interface [polypeptide binding]; other site 1194526000417 conserved gate region; other site 1194526000418 putative PBP binding loops; other site 1194526000419 ABC-ATPase subunit interface; other site 1194526000420 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1194526000421 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1194526000422 Walker A/P-loop; other site 1194526000423 ATP binding site [chemical binding]; other site 1194526000424 Q-loop/lid; other site 1194526000425 ABC transporter signature motif; other site 1194526000426 Walker B; other site 1194526000427 D-loop; other site 1194526000428 H-loop/switch region; other site 1194526000429 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1194526000430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1194526000431 Walker A/P-loop; other site 1194526000432 ATP binding site [chemical binding]; other site 1194526000433 Q-loop/lid; other site 1194526000434 ABC transporter signature motif; other site 1194526000435 Walker B; other site 1194526000436 D-loop; other site 1194526000437 H-loop/switch region; other site 1194526000438 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1194526000439 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1194526000440 DNA binding residues [nucleotide binding] 1194526000441 putative dimer interface [polypeptide binding]; other site 1194526000442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1194526000443 catalytic tetrad [active] 1194526000444 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1194526000445 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1194526000446 active site 1194526000447 Predicted membrane protein [Function unknown]; Region: COG3212 1194526000448 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1194526000449 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1194526000450 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1194526000451 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1194526000452 Rrf2 family protein; Region: rrf2_super; TIGR00738 1194526000453 Transcriptional regulator; Region: Rrf2; pfam02082 1194526000454 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1194526000455 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1194526000456 NAD binding site [chemical binding]; other site 1194526000457 substrate binding site [chemical binding]; other site 1194526000458 putative active site [active] 1194526000459 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1194526000460 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1194526000461 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1194526000462 Pyruvate formate lyase 1; Region: PFL1; cd01678 1194526000463 coenzyme A binding site [chemical binding]; other site 1194526000464 active site 1194526000465 catalytic residues [active] 1194526000466 glycine loop; other site 1194526000467 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1194526000468 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1194526000469 FeS/SAM binding site; other site 1194526000470 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1194526000471 Predicted membrane protein [Function unknown]; Region: COG1288 1194526000472 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1194526000473 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1194526000474 active site 1194526000475 tetramer interface; other site 1194526000476 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1194526000477 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1194526000478 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1194526000479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1194526000480 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1194526000481 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1194526000482 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1194526000483 Walker A/P-loop; other site 1194526000484 ATP binding site [chemical binding]; other site 1194526000485 Q-loop/lid; other site 1194526000486 ABC transporter signature motif; other site 1194526000487 Walker B; other site 1194526000488 D-loop; other site 1194526000489 H-loop/switch region; other site 1194526000490 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1194526000491 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1194526000492 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1194526000493 dimer interface [polypeptide binding]; other site 1194526000494 active site 1194526000495 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1194526000496 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1194526000497 Isochorismatase family; Region: Isochorismatase; pfam00857 1194526000498 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1194526000499 catalytic triad [active] 1194526000500 conserved cis-peptide bond; other site 1194526000501 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 1194526000502 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1194526000503 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1194526000504 DNA binding site [nucleotide binding] 1194526000505 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1194526000506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1194526000507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526000508 active site 1194526000509 phosphorylation site [posttranslational modification] 1194526000510 intermolecular recognition site; other site 1194526000511 dimerization interface [polypeptide binding]; other site 1194526000512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1194526000513 DNA binding site [nucleotide binding] 1194526000514 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1194526000515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526000516 Walker A/P-loop; other site 1194526000517 ATP binding site [chemical binding]; other site 1194526000518 Q-loop/lid; other site 1194526000519 ABC transporter signature motif; other site 1194526000520 Walker B; other site 1194526000521 D-loop; other site 1194526000522 H-loop/switch region; other site 1194526000523 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1194526000524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1194526000525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1194526000526 dimer interface [polypeptide binding]; other site 1194526000527 phosphorylation site [posttranslational modification] 1194526000528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526000529 ATP binding site [chemical binding]; other site 1194526000530 Mg2+ binding site [ion binding]; other site 1194526000531 G-X-G motif; other site 1194526000532 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 1194526000533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526000534 active site 1194526000535 motif I; other site 1194526000536 motif II; other site 1194526000537 VanW like protein; Region: VanW; pfam04294 1194526000538 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1194526000539 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1194526000540 Walker A/P-loop; other site 1194526000541 ATP binding site [chemical binding]; other site 1194526000542 Q-loop/lid; other site 1194526000543 ABC transporter signature motif; other site 1194526000544 Walker B; other site 1194526000545 D-loop; other site 1194526000546 H-loop/switch region; other site 1194526000547 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1194526000548 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1194526000549 FtsX-like permease family; Region: FtsX; pfam02687 1194526000550 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1194526000551 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1194526000552 NADP binding site [chemical binding]; other site 1194526000553 putative substrate binding site [chemical binding]; other site 1194526000554 active site 1194526000555 short chain dehydrogenase; Provisional; Region: PRK08219 1194526000556 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1194526000557 NADP binding site [chemical binding]; other site 1194526000558 active site 1194526000559 steroid binding site; other site 1194526000560 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1194526000561 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 1194526000562 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1194526000563 EamA-like transporter family; Region: EamA; pfam00892 1194526000564 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1194526000565 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1194526000566 transmembrane helices; other site 1194526000567 DinB superfamily; Region: DinB_2; pfam12867 1194526000568 Predicted transcriptional regulators [Transcription]; Region: COG1695 1194526000569 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1194526000570 hypothetical protein; Validated; Region: PRK07668 1194526000571 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1194526000572 putative substrate binding pocket [chemical binding]; other site 1194526000573 AC domain interface; other site 1194526000574 catalytic triad [active] 1194526000575 AB domain interface; other site 1194526000576 interchain disulfide; other site 1194526000577 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1194526000578 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1194526000579 active site residue [active] 1194526000580 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1194526000581 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1194526000582 Strictosidine synthase; Region: Str_synth; pfam03088 1194526000583 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1194526000584 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1194526000585 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1194526000586 active site 1194526000587 metal binding site [ion binding]; metal-binding site 1194526000588 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1194526000589 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1194526000590 Predicted membrane protein [Function unknown]; Region: COG1288 1194526000591 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1194526000592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526000593 Walker A/P-loop; other site 1194526000594 ATP binding site [chemical binding]; other site 1194526000595 Q-loop/lid; other site 1194526000596 AAA domain; Region: AAA_21; pfam13304 1194526000597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526000598 ABC transporter signature motif; other site 1194526000599 Walker B; other site 1194526000600 D-loop; other site 1194526000601 H-loop/switch region; other site 1194526000602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526000603 Walker A/P-loop; other site 1194526000604 ATP binding site [chemical binding]; other site 1194526000605 Q-loop/lid; other site 1194526000606 ABC transporter signature motif; other site 1194526000607 Walker B; other site 1194526000608 D-loop; other site 1194526000609 H-loop/switch region; other site 1194526000610 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1194526000611 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1194526000612 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1194526000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000614 putative substrate translocation pore; other site 1194526000615 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1194526000616 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1194526000617 active site 1194526000618 metal binding site [ion binding]; metal-binding site 1194526000619 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1194526000620 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1194526000621 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1194526000622 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1194526000623 Walker A/P-loop; other site 1194526000624 ATP binding site [chemical binding]; other site 1194526000625 Q-loop/lid; other site 1194526000626 ABC transporter signature motif; other site 1194526000627 Walker B; other site 1194526000628 D-loop; other site 1194526000629 H-loop/switch region; other site 1194526000630 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1194526000631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526000632 dimer interface [polypeptide binding]; other site 1194526000633 conserved gate region; other site 1194526000634 ABC-ATPase subunit interface; other site 1194526000635 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1194526000636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526000637 dimer interface [polypeptide binding]; other site 1194526000638 conserved gate region; other site 1194526000639 ABC-ATPase subunit interface; other site 1194526000640 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1194526000641 Staphostatin B; Region: Staphostatin_B; pfam09023 1194526000642 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1194526000643 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1194526000644 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1194526000645 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1194526000646 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1194526000647 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1194526000648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000649 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526000650 putative substrate translocation pore; other site 1194526000651 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1194526000652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000653 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1194526000654 putative substrate translocation pore; other site 1194526000655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526000656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526000657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526000658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526000659 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1194526000660 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1194526000661 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1194526000662 Protein export membrane protein; Region: SecD_SecF; cl14618 1194526000663 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1194526000664 hypothetical protein; Provisional; Region: PRK11281 1194526000665 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1194526000666 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1194526000667 CHAP domain; Region: CHAP; pfam05257 1194526000668 Predicted membrane protein [Function unknown]; Region: COG1511 1194526000669 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1194526000670 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1194526000671 acetoin reductase; Validated; Region: PRK08643 1194526000672 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1194526000673 NAD binding site [chemical binding]; other site 1194526000674 homotetramer interface [polypeptide binding]; other site 1194526000675 homodimer interface [polypeptide binding]; other site 1194526000676 active site 1194526000677 substrate binding site [chemical binding]; other site 1194526000678 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1194526000679 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1194526000680 metal binding site [ion binding]; metal-binding site 1194526000681 dimer interface [polypeptide binding]; other site 1194526000682 Peptidase family M23; Region: Peptidase_M23; pfam01551 1194526000683 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1194526000684 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1194526000685 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1194526000686 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1194526000687 active site 1194526000688 Zn binding site [ion binding]; other site 1194526000689 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1194526000690 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1194526000691 putative active site [active] 1194526000692 putative metal binding site [ion binding]; other site 1194526000693 ornithine carbamoyltransferase; Validated; Region: PRK02102 1194526000694 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1194526000695 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1194526000696 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1194526000697 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1194526000698 dimer interface [polypeptide binding]; other site 1194526000699 PYR/PP interface [polypeptide binding]; other site 1194526000700 TPP binding site [chemical binding]; other site 1194526000701 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1194526000702 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1194526000703 TPP-binding site [chemical binding]; other site 1194526000704 dimer interface [polypeptide binding]; other site 1194526000705 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1194526000706 MarR family; Region: MarR_2; pfam12802 1194526000707 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1194526000708 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 1194526000709 potential frameshift: common BLAST hit: gi|27469115|ref|NP_765752.1| alkaline phosphatase 1194526000710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1194526000711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526000712 active site 1194526000713 phosphorylation site [posttranslational modification] 1194526000714 intermolecular recognition site; other site 1194526000715 dimerization interface [polypeptide binding]; other site 1194526000716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1194526000717 DNA binding site [nucleotide binding] 1194526000718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1194526000719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526000720 ATP binding site [chemical binding]; other site 1194526000721 Mg2+ binding site [ion binding]; other site 1194526000722 G-X-G motif; other site 1194526000723 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1194526000724 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1194526000725 Walker A/P-loop; other site 1194526000726 ATP binding site [chemical binding]; other site 1194526000727 Q-loop/lid; other site 1194526000728 ABC transporter signature motif; other site 1194526000729 Walker B; other site 1194526000730 D-loop; other site 1194526000731 H-loop/switch region; other site 1194526000732 FtsX-like permease family; Region: FtsX; pfam02687 1194526000733 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1194526000734 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1194526000735 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1194526000736 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1194526000737 Active Sites [active] 1194526000738 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1194526000739 Flavodoxin; Region: Flavodoxin_1; pfam00258 1194526000740 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1194526000741 FAD binding pocket [chemical binding]; other site 1194526000742 FAD binding motif [chemical binding]; other site 1194526000743 catalytic residues [active] 1194526000744 NAD binding pocket [chemical binding]; other site 1194526000745 phosphate binding motif [ion binding]; other site 1194526000746 beta-alpha-beta structure motif; other site 1194526000747 sulfite reductase subunit beta; Provisional; Region: PRK13504 1194526000748 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1194526000749 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1194526000750 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1194526000751 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1194526000752 active site 1194526000753 SAM binding site [chemical binding]; other site 1194526000754 homodimer interface [polypeptide binding]; other site 1194526000755 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1194526000756 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1194526000757 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1194526000758 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1194526000759 ATP-sulfurylase; Region: ATPS; cd00517 1194526000760 active site 1194526000761 HXXH motif; other site 1194526000762 flexible loop; other site 1194526000763 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1194526000764 ligand-binding site [chemical binding]; other site 1194526000765 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1194526000766 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1194526000767 metal binding site [ion binding]; metal-binding site 1194526000768 dimer interface [polypeptide binding]; other site 1194526000769 CHAP domain; Region: CHAP; cl17642 1194526000770 Surface antigen [General function prediction only]; Region: COG3942 1194526000771 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1194526000772 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1194526000773 effector binding site; other site 1194526000774 active site 1194526000775 Zn binding site [ion binding]; other site 1194526000776 glycine loop; other site 1194526000777 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1194526000778 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1194526000779 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1194526000780 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1194526000781 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1194526000782 Predicted transcriptional regulators [Transcription]; Region: COG1510 1194526000783 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1194526000784 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1194526000785 tetramerization interface [polypeptide binding]; other site 1194526000786 NAD(P) binding site [chemical binding]; other site 1194526000787 catalytic residues [active] 1194526000788 choline dehydrogenase; Validated; Region: PRK02106 1194526000789 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1194526000790 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1194526000791 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1194526000792 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1194526000793 metal binding site [ion binding]; metal-binding site 1194526000794 dimer interface [polypeptide binding]; other site 1194526000795 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1194526000796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526000797 putative substrate translocation pore; other site 1194526000798 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1194526000799 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1194526000800 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1194526000801 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1194526000802 active site 1194526000803 acyl-activating enzyme (AAE) consensus motif; other site 1194526000804 putative CoA binding site [chemical binding]; other site 1194526000805 AMP binding site [chemical binding]; other site 1194526000806 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1194526000807 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1194526000808 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1194526000809 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1194526000810 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1194526000811 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1194526000812 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1194526000813 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1194526000814 beta-galactosidase; Region: BGL; TIGR03356 1194526000815 YCII-related domain; Region: YCII; cl00999 1194526000816 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1194526000817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1194526000818 putative DNA binding site [nucleotide binding]; other site 1194526000819 putative Zn2+ binding site [ion binding]; other site 1194526000820 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1194526000821 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1194526000822 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1194526000823 catalytic residue [active] 1194526000824 AAA domain; Region: AAA_17; pfam13207 1194526000825 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1194526000826 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1194526000827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526000828 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1194526000829 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1194526000830 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1194526000831 inhibitor-cofactor binding pocket; inhibition site 1194526000832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526000833 catalytic residue [active] 1194526000834 amino acid transporter; Region: 2A0306; TIGR00909 1194526000835 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1194526000836 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1194526000837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1194526000838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1194526000839 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1194526000840 putative dimerization interface [polypeptide binding]; other site 1194526000841 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1194526000842 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1194526000843 dimer interface [polypeptide binding]; other site 1194526000844 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1194526000845 NAD binding site [chemical binding]; other site 1194526000846 substrate binding site [chemical binding]; other site 1194526000847 acetolactate synthase; Reviewed; Region: PRK08617 1194526000848 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1194526000849 PYR/PP interface [polypeptide binding]; other site 1194526000850 dimer interface [polypeptide binding]; other site 1194526000851 TPP binding site [chemical binding]; other site 1194526000852 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1194526000853 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1194526000854 TPP-binding site [chemical binding]; other site 1194526000855 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1194526000856 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1194526000857 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1194526000858 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1194526000859 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1194526000860 oligomerization interface [polypeptide binding]; other site 1194526000861 active site 1194526000862 metal binding site [ion binding]; metal-binding site 1194526000863 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1194526000864 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1194526000865 active site 1194526000866 ATP-binding site [chemical binding]; other site 1194526000867 pantoate-binding site; other site 1194526000868 HXXH motif; other site 1194526000869 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1194526000870 tetramerization interface [polypeptide binding]; other site 1194526000871 active site 1194526000872 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1194526000873 Predicted membrane protein [Function unknown]; Region: COG4640 1194526000874 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1194526000875 Double zinc ribbon; Region: DZR; pfam12773 1194526000876 Predicted membrane protein [Function unknown]; Region: COG4640 1194526000877 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1194526000878 Predicted acyl esterases [General function prediction only]; Region: COG2936 1194526000879 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1194526000880 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1194526000881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526000882 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1194526000883 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1194526000884 dimer interface [polypeptide binding]; other site 1194526000885 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1194526000886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1194526000887 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1194526000888 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1194526000889 quinone interaction residues [chemical binding]; other site 1194526000890 active site 1194526000891 catalytic residues [active] 1194526000892 FMN binding site [chemical binding]; other site 1194526000893 substrate binding site [chemical binding]; other site 1194526000894 Phosphotransferase enzyme family; Region: APH; pfam01636 1194526000895 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1194526000896 active site 1194526000897 substrate binding site [chemical binding]; other site 1194526000898 ATP binding site [chemical binding]; other site 1194526000899 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1194526000900 active site 1194526000901 ATP binding site [chemical binding]; other site 1194526000902 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1194526000903 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1194526000904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526000905 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1194526000906 NAD(P) binding site [chemical binding]; other site 1194526000907 active site 1194526000908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526000909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526000910 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 1194526000911 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1194526000912 NmrA-like family; Region: NmrA; pfam05368 1194526000913 NADP binding site [chemical binding]; other site 1194526000914 active site 1194526000915 regulatory binding site [polypeptide binding]; other site 1194526000916 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1194526000917 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1194526000918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1194526000919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526000920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526000921 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1194526000922 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1194526000923 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1194526000924 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1194526000925 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1194526000926 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1194526000927 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1194526000928 catalytic residue [active] 1194526000929 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1194526000930 active site lid residues [active] 1194526000931 substrate binding pocket [chemical binding]; other site 1194526000932 catalytic residues [active] 1194526000933 substrate-Mg2+ binding site; other site 1194526000934 aspartate-rich region 1; other site 1194526000935 aspartate-rich region 2; other site 1194526000936 phytoene desaturase; Region: crtI_fam; TIGR02734 1194526000937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1194526000938 transaminase; Reviewed; Region: PRK08068 1194526000939 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1194526000940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526000941 homodimer interface [polypeptide binding]; other site 1194526000942 catalytic residue [active] 1194526000943 D-lactate dehydrogenase; Validated; Region: PRK08605 1194526000944 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1194526000945 homodimer interface [polypeptide binding]; other site 1194526000946 ligand binding site [chemical binding]; other site 1194526000947 NAD binding site [chemical binding]; other site 1194526000948 catalytic site [active] 1194526000949 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1194526000950 metal-binding site [ion binding] 1194526000951 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1194526000952 metal-binding site [ion binding] 1194526000953 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1194526000954 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1194526000955 metal-binding site [ion binding] 1194526000956 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1194526000957 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1194526000958 short chain dehydrogenase; Provisional; Region: PRK06701 1194526000959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526000960 NAD(P) binding site [chemical binding]; other site 1194526000961 active site 1194526000962 maltose O-acetyltransferase; Provisional; Region: PRK10092 1194526000963 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1194526000964 active site 1194526000965 substrate binding site [chemical binding]; other site 1194526000966 trimer interface [polypeptide binding]; other site 1194526000967 CoA binding site [chemical binding]; other site 1194526000968 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1194526000969 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1194526000970 Glutamate binding site [chemical binding]; other site 1194526000971 homodimer interface [polypeptide binding]; other site 1194526000972 NAD binding site [chemical binding]; other site 1194526000973 catalytic residues [active] 1194526000974 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1194526000975 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1194526000976 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1194526000977 G1 box; other site 1194526000978 GTP/Mg2+ binding site [chemical binding]; other site 1194526000979 Switch I region; other site 1194526000980 G2 box; other site 1194526000981 G3 box; other site 1194526000982 Switch II region; other site 1194526000983 G4 box; other site 1194526000984 G5 box; other site 1194526000985 Nucleoside recognition; Region: Gate; pfam07670 1194526000986 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1194526000987 Nucleoside recognition; Region: Gate; pfam07670 1194526000988 YrhK-like protein; Region: YrhK; pfam14145 1194526000989 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1194526000990 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1194526000991 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1194526000992 DNA binding site [nucleotide binding] 1194526000993 active site 1194526000994 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1194526000995 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1194526000996 dimer interface [polypeptide binding]; other site 1194526000997 active site 1194526000998 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1194526000999 homodimer interface [polypeptide binding]; other site 1194526001000 catalytic residues [active] 1194526001001 NAD binding site [chemical binding]; other site 1194526001002 substrate binding pocket [chemical binding]; other site 1194526001003 flexible flap; other site 1194526001004 CHAP domain; Region: CHAP; pfam05257 1194526001005 Surface antigen [General function prediction only]; Region: COG3942 1194526001006 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1194526001007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1194526001008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1194526001009 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1194526001010 putative dimerization interface [polypeptide binding]; other site 1194526001011 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1194526001012 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1194526001013 pyruvate oxidase; Provisional; Region: PRK08611 1194526001014 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1194526001015 PYR/PP interface [polypeptide binding]; other site 1194526001016 dimer interface [polypeptide binding]; other site 1194526001017 tetramer interface [polypeptide binding]; other site 1194526001018 TPP binding site [chemical binding]; other site 1194526001019 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1194526001020 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1194526001021 TPP-binding site [chemical binding]; other site 1194526001022 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1194526001023 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1194526001024 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1194526001025 active site turn [active] 1194526001026 phosphorylation site [posttranslational modification] 1194526001027 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1194526001028 HPr interaction site; other site 1194526001029 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1194526001030 active site 1194526001031 phosphorylation site [posttranslational modification] 1194526001032 CAAX protease self-immunity; Region: Abi; pfam02517 1194526001033 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1194526001034 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1194526001035 catalytic Zn binding site [ion binding]; other site 1194526001036 structural Zn binding site [ion binding]; other site 1194526001037 NAD(P) binding site [chemical binding]; other site 1194526001038 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1194526001039 active site 1194526001040 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1194526001041 catalytic residues [active] 1194526001042 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1194526001043 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1194526001044 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1194526001045 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1194526001046 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1194526001047 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1194526001048 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1194526001049 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1194526001050 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 1194526001051 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1194526001052 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1194526001053 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1194526001054 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1194526001055 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1194526001056 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1194526001057 N- and C-terminal domain interface [polypeptide binding]; other site 1194526001058 D-xylulose kinase; Region: XylB; TIGR01312 1194526001059 active site 1194526001060 MgATP binding site [chemical binding]; other site 1194526001061 catalytic site [active] 1194526001062 metal binding site [ion binding]; metal-binding site 1194526001063 xylulose binding site [chemical binding]; other site 1194526001064 homodimer interface [polypeptide binding]; other site 1194526001065 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1194526001066 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1194526001067 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1194526001068 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1194526001069 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1194526001070 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1194526001071 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1194526001072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526001073 Coenzyme A binding pocket [chemical binding]; other site 1194526001074 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1194526001075 active site 1194526001076 catalytic site [active] 1194526001077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526001078 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1194526001079 active site 1194526001080 motif I; other site 1194526001081 motif II; other site 1194526001082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1194526001083 D-lactate dehydrogenase; Provisional; Region: PRK12480 1194526001084 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1194526001085 homodimer interface [polypeptide binding]; other site 1194526001086 ligand binding site [chemical binding]; other site 1194526001087 NAD binding site [chemical binding]; other site 1194526001088 catalytic site [active] 1194526001089 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1194526001090 dimer interface [polypeptide binding]; other site 1194526001091 FMN binding site [chemical binding]; other site 1194526001092 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1194526001093 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1194526001094 NAD(P) binding site [chemical binding]; other site 1194526001095 catalytic residues [active] 1194526001096 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1194526001097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1194526001098 substrate binding pocket [chemical binding]; other site 1194526001099 membrane-bound complex binding site; other site 1194526001100 hinge residues; other site 1194526001101 WYL domain; Region: WYL; pfam13280 1194526001102 TM2 domain; Region: TM2; pfam05154 1194526001103 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1194526001104 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1194526001105 putative metal binding site [ion binding]; other site 1194526001106 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1194526001107 active site 1194526001108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526001109 Coenzyme A binding pocket [chemical binding]; other site 1194526001110 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1194526001111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1194526001112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1194526001113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1194526001114 dimerization interface [polypeptide binding]; other site 1194526001115 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1194526001116 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1194526001117 NAD binding site [chemical binding]; other site 1194526001118 catalytic residues [active] 1194526001119 substrate binding site [chemical binding]; other site 1194526001120 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1194526001121 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1194526001122 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1194526001123 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1194526001124 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1194526001125 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1194526001126 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1194526001127 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1194526001128 ATP binding site [chemical binding]; other site 1194526001129 substrate interface [chemical binding]; other site 1194526001130 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1194526001131 ThiS interaction site; other site 1194526001132 putative active site [active] 1194526001133 tetramer interface [polypeptide binding]; other site 1194526001134 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1194526001135 thiS-thiF/thiG interaction site; other site 1194526001136 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1194526001137 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1194526001138 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1194526001139 active site 1194526001140 thiamine phosphate binding site [chemical binding]; other site 1194526001141 pyrophosphate binding site [ion binding]; other site 1194526001142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001143 D-galactonate transporter; Region: 2A0114; TIGR00893 1194526001144 putative substrate translocation pore; other site 1194526001145 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1194526001146 Predicted membrane protein [Function unknown]; Region: COG1289 1194526001147 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1194526001148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1194526001149 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1194526001150 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1194526001151 synthetase active site [active] 1194526001152 NTP binding site [chemical binding]; other site 1194526001153 metal binding site [ion binding]; metal-binding site 1194526001154 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1194526001155 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1194526001156 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1194526001157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1194526001158 DNA-binding site [nucleotide binding]; DNA binding site 1194526001159 FCD domain; Region: FCD; pfam07729 1194526001160 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1194526001161 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1194526001162 N- and C-terminal domain interface [polypeptide binding]; other site 1194526001163 active site 1194526001164 catalytic site [active] 1194526001165 metal binding site [ion binding]; metal-binding site 1194526001166 carbohydrate binding site [chemical binding]; other site 1194526001167 ATP binding site [chemical binding]; other site 1194526001168 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1194526001169 GntP family permease; Region: GntP_permease; pfam02447 1194526001170 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1194526001171 active site 1194526001172 tetramer interface; other site 1194526001173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1194526001174 active site 1194526001175 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1194526001176 active site 1194526001177 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1194526001178 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1194526001179 active site 1194526001180 substrate binding site [chemical binding]; other site 1194526001181 metal binding site [ion binding]; metal-binding site 1194526001182 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1194526001183 active site 1194526001184 8-oxo-dGMP binding site [chemical binding]; other site 1194526001185 nudix motif; other site 1194526001186 metal binding site [ion binding]; metal-binding site 1194526001187 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1194526001188 PLD-like domain; Region: PLDc_2; pfam13091 1194526001189 putative homodimer interface [polypeptide binding]; other site 1194526001190 putative active site [active] 1194526001191 catalytic site [active] 1194526001192 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1194526001193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1194526001194 ATP binding site [chemical binding]; other site 1194526001195 putative Mg++ binding site [ion binding]; other site 1194526001196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526001197 nucleotide binding region [chemical binding]; other site 1194526001198 ATP-binding site [chemical binding]; other site 1194526001199 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1194526001200 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1194526001201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1194526001202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526001203 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1194526001204 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1194526001205 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1194526001206 tetramer interface [polypeptide binding]; other site 1194526001207 TPP-binding site [chemical binding]; other site 1194526001208 heterodimer interface [polypeptide binding]; other site 1194526001209 phosphorylation loop region [posttranslational modification] 1194526001210 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1194526001211 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1194526001212 alpha subunit interface [polypeptide binding]; other site 1194526001213 TPP binding site [chemical binding]; other site 1194526001214 heterodimer interface [polypeptide binding]; other site 1194526001215 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1194526001216 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1194526001217 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1194526001218 E3 interaction surface; other site 1194526001219 lipoyl attachment site [posttranslational modification]; other site 1194526001220 e3 binding domain; Region: E3_binding; pfam02817 1194526001221 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1194526001222 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1194526001223 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1194526001224 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1194526001225 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1194526001226 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1194526001227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526001228 NAD(P) binding site [chemical binding]; other site 1194526001229 active site 1194526001230 acetylornithine deacetylase; Validated; Region: PRK08596 1194526001231 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1194526001232 metal binding site [ion binding]; metal-binding site 1194526001233 polyphosphate kinase; Provisional; Region: PRK05443 1194526001234 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1194526001235 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1194526001236 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1194526001237 putative domain interface [polypeptide binding]; other site 1194526001238 putative active site [active] 1194526001239 catalytic site [active] 1194526001240 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1194526001241 putative domain interface [polypeptide binding]; other site 1194526001242 putative active site [active] 1194526001243 catalytic site [active] 1194526001244 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1194526001245 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1194526001246 nucleotide binding site [chemical binding]; other site 1194526001247 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1194526001248 AbgT putative transporter family; Region: ABG_transport; pfam03806 1194526001249 short chain dehydrogenase; Validated; Region: PRK08589 1194526001250 classical (c) SDRs; Region: SDR_c; cd05233 1194526001251 NAD(P) binding site [chemical binding]; other site 1194526001252 active site 1194526001253 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1194526001254 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1194526001255 oligomer interface [polypeptide binding]; other site 1194526001256 active site 1194526001257 metal binding site [ion binding]; metal-binding site 1194526001258 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 1194526001259 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1194526001260 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1194526001261 active site 1194526001262 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1194526001263 arsenical pump membrane protein; Provisional; Region: PRK15445 1194526001264 transmembrane helices; other site 1194526001265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1194526001266 dimerization interface [polypeptide binding]; other site 1194526001267 putative DNA binding site [nucleotide binding]; other site 1194526001268 putative Zn2+ binding site [ion binding]; other site 1194526001269 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1194526001270 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1194526001271 active site 1194526001272 FMN binding site [chemical binding]; other site 1194526001273 substrate binding site [chemical binding]; other site 1194526001274 3Fe-4S cluster binding site [ion binding]; other site 1194526001275 CAAX protease self-immunity; Region: Abi; cl00558 1194526001276 CAAX protease self-immunity; Region: Abi; pfam02517 1194526001277 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1194526001278 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1194526001279 Walker A/P-loop; other site 1194526001280 ATP binding site [chemical binding]; other site 1194526001281 Q-loop/lid; other site 1194526001282 ABC transporter signature motif; other site 1194526001283 Walker B; other site 1194526001284 D-loop; other site 1194526001285 H-loop/switch region; other site 1194526001286 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1194526001287 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1194526001288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001289 putative substrate translocation pore; other site 1194526001290 potential frameshift: common BLAST hit: gi|385783490|ref|YP_005759663.1| putative carboxylesterase 1194526001291 Amino acid permease; Region: AA_permease; pfam00324 1194526001292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1194526001293 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1194526001294 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1194526001295 acetoin reductase; Validated; Region: PRK08643 1194526001296 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1194526001297 NAD binding site [chemical binding]; other site 1194526001298 homotetramer interface [polypeptide binding]; other site 1194526001299 homodimer interface [polypeptide binding]; other site 1194526001300 active site 1194526001301 substrate binding site [chemical binding]; other site 1194526001302 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1194526001303 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1194526001304 Walker A/P-loop; other site 1194526001305 ATP binding site [chemical binding]; other site 1194526001306 Q-loop/lid; other site 1194526001307 ABC transporter signature motif; other site 1194526001308 Walker B; other site 1194526001309 D-loop; other site 1194526001310 H-loop/switch region; other site 1194526001311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1194526001312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526001313 dimer interface [polypeptide binding]; other site 1194526001314 conserved gate region; other site 1194526001315 putative PBP binding loops; other site 1194526001316 ABC-ATPase subunit interface; other site 1194526001317 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1194526001318 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1194526001319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526001320 dimer interface [polypeptide binding]; other site 1194526001321 conserved gate region; other site 1194526001322 ABC-ATPase subunit interface; other site 1194526001323 antiholin-like protein LrgB; Provisional; Region: PRK04288 1194526001324 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1194526001325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526001327 putative substrate translocation pore; other site 1194526001328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001329 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1194526001330 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1194526001331 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1194526001332 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1194526001333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1194526001334 Coenzyme A binding pocket [chemical binding]; other site 1194526001335 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1194526001336 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1194526001337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526001338 NAD(P) binding site [chemical binding]; other site 1194526001339 active site 1194526001340 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1194526001341 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1194526001342 Beta-lactamase; Region: Beta-lactamase; pfam00144 1194526001343 Amino acid permease; Region: AA_permease_2; pfam13520 1194526001344 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1194526001345 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1194526001346 Spore germination protein; Region: Spore_permease; cl17796 1194526001347 putative phosphoesterase; Region: acc_ester; TIGR03729 1194526001348 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1194526001349 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1194526001350 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1194526001351 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1194526001352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001353 putative substrate translocation pore; other site 1194526001354 Predicted transcriptional regulators [Transcription]; Region: COG1695 1194526001355 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1194526001356 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1194526001357 glycerate kinase; Region: TIGR00045 1194526001358 Predicted membrane protein [Function unknown]; Region: COG2246 1194526001359 GtrA-like protein; Region: GtrA; pfam04138 1194526001360 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1194526001361 Cation efflux family; Region: Cation_efflux; pfam01545 1194526001362 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1194526001363 catalytic core [active] 1194526001364 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1194526001365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526001367 putative substrate translocation pore; other site 1194526001368 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1194526001369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1194526001370 substrate binding pocket [chemical binding]; other site 1194526001371 membrane-bound complex binding site; other site 1194526001372 hinge residues; other site 1194526001373 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1194526001374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526001375 dimer interface [polypeptide binding]; other site 1194526001376 conserved gate region; other site 1194526001377 putative PBP binding loops; other site 1194526001378 ABC-ATPase subunit interface; other site 1194526001379 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1194526001380 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1194526001381 Walker A/P-loop; other site 1194526001382 ATP binding site [chemical binding]; other site 1194526001383 Q-loop/lid; other site 1194526001384 ABC transporter signature motif; other site 1194526001385 Walker B; other site 1194526001386 D-loop; other site 1194526001387 H-loop/switch region; other site 1194526001388 FemAB family; Region: FemAB; pfam02388 1194526001389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1194526001390 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1194526001391 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1194526001392 Thioredoxin; Region: Thioredoxin_4; cl17273 1194526001393 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1194526001394 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1194526001395 intersubunit interface [polypeptide binding]; other site 1194526001396 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1194526001397 putative hydrophobic ligand binding site [chemical binding]; other site 1194526001398 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1194526001399 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1194526001400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526001401 Coenzyme A binding pocket [chemical binding]; other site 1194526001402 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1194526001403 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1194526001404 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1194526001405 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1194526001406 putative active site [active] 1194526001407 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1194526001408 active site 1194526001409 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1194526001410 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1194526001411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526001412 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1194526001413 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1194526001414 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1194526001415 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1194526001416 [2Fe-2S] cluster binding site [ion binding]; other site 1194526001417 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1194526001418 active site 1194526001419 SAM binding site [chemical binding]; other site 1194526001420 homodimer interface [polypeptide binding]; other site 1194526001421 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1194526001422 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1194526001423 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1194526001424 molybdopterin cofactor binding site; other site 1194526001425 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1194526001426 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1194526001427 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1194526001428 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1194526001429 molybdopterin cofactor binding site; other site 1194526001430 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1194526001431 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1194526001432 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1194526001433 GAF domain; Region: GAF; cl17456 1194526001434 potential frameshift: common BLAST hit: gi|387781348|ref|YP_005756146.1| roxygen sensor histidine kinase NreB 1194526001435 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1194526001436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526001437 active site 1194526001438 phosphorylation site [posttranslational modification] 1194526001439 intermolecular recognition site; other site 1194526001440 dimerization interface [polypeptide binding]; other site 1194526001441 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1194526001442 DNA binding residues [nucleotide binding] 1194526001443 dimerization interface [polypeptide binding]; other site 1194526001444 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1194526001445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001446 putative substrate translocation pore; other site 1194526001447 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1194526001448 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1194526001449 putative dimer interface [polypeptide binding]; other site 1194526001450 MarR family; Region: MarR_2; cl17246 1194526001451 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1194526001452 dimer interface [polypeptide binding]; other site 1194526001453 FMN binding site [chemical binding]; other site 1194526001454 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1194526001455 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1194526001456 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1194526001457 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1194526001458 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1194526001459 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1194526001460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1194526001461 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1194526001462 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1194526001463 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1194526001464 active site turn [active] 1194526001465 phosphorylation site [posttranslational modification] 1194526001466 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1194526001467 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1194526001468 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1194526001469 Cl binding site [ion binding]; other site 1194526001470 oligomer interface [polypeptide binding]; other site 1194526001471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526001472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526001473 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1194526001474 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1194526001475 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1194526001476 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1194526001477 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 1194526001478 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1194526001479 classical (c) SDRs; Region: SDR_c; cd05233 1194526001480 NAD(P) binding site [chemical binding]; other site 1194526001481 active site 1194526001482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1194526001483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1194526001484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1194526001485 dimerization interface [polypeptide binding]; other site 1194526001486 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1194526001487 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1194526001488 active site 1194526001489 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1194526001490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526001491 NAD(P) binding site [chemical binding]; other site 1194526001492 active site 1194526001493 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1194526001494 MarR family; Region: MarR_2; pfam12802 1194526001495 MarR family; Region: MarR_2; cl17246 1194526001496 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1194526001497 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1194526001498 CopC domain; Region: CopC; pfam04234 1194526001499 Copper resistance protein D; Region: CopD; cl00563 1194526001500 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1194526001501 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1194526001502 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1194526001503 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1194526001504 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526001505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526001506 Coenzyme A binding pocket [chemical binding]; other site 1194526001507 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1194526001508 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1194526001509 NAD(P) binding site [chemical binding]; other site 1194526001510 Imelysin; Region: Peptidase_M75; pfam09375 1194526001511 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1194526001512 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1194526001513 Iron permease FTR1 family; Region: FTR1; cl00475 1194526001514 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1194526001515 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1194526001516 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1194526001517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526001518 Coenzyme A binding pocket [chemical binding]; other site 1194526001519 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1194526001520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1194526001521 active site 1194526001522 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1194526001523 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1194526001524 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1194526001525 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1194526001526 L-lactate permease; Region: Lactate_perm; cl00701 1194526001527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1194526001528 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1194526001529 putative ADP-binding pocket [chemical binding]; other site 1194526001530 malate:quinone oxidoreductase; Validated; Region: PRK05257 1194526001531 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1194526001532 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1194526001533 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1194526001534 LytTr DNA-binding domain; Region: LytTR; smart00850 1194526001535 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1194526001536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1194526001537 dimerization interface [polypeptide binding]; other site 1194526001538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1194526001539 dimer interface [polypeptide binding]; other site 1194526001540 phosphorylation site [posttranslational modification] 1194526001541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526001542 ATP binding site [chemical binding]; other site 1194526001543 Mg2+ binding site [ion binding]; other site 1194526001544 G-X-G motif; other site 1194526001545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1194526001546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526001547 active site 1194526001548 phosphorylation site [posttranslational modification] 1194526001549 intermolecular recognition site; other site 1194526001550 dimerization interface [polypeptide binding]; other site 1194526001551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1194526001552 DNA binding site [nucleotide binding] 1194526001553 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1194526001554 FtsX-like permease family; Region: FtsX; pfam02687 1194526001555 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1194526001556 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1194526001557 Walker A/P-loop; other site 1194526001558 ATP binding site [chemical binding]; other site 1194526001559 Q-loop/lid; other site 1194526001560 ABC transporter signature motif; other site 1194526001561 Walker B; other site 1194526001562 D-loop; other site 1194526001563 H-loop/switch region; other site 1194526001564 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1194526001565 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1194526001566 putative active site [active] 1194526001567 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1194526001568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1194526001569 putative DNA binding site [nucleotide binding]; other site 1194526001570 putative Zn2+ binding site [ion binding]; other site 1194526001571 Predicted membrane protein [Function unknown]; Region: COG4640 1194526001572 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1194526001573 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1194526001574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001575 putative substrate translocation pore; other site 1194526001576 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1194526001577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526001578 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1194526001579 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1194526001580 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1194526001581 HlyD family secretion protein; Region: HlyD_3; pfam13437 1194526001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001583 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1194526001584 putative substrate translocation pore; other site 1194526001585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001586 putative substrate translocation pore; other site 1194526001587 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1194526001588 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1194526001589 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1194526001590 active site 1194526001591 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1194526001592 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1194526001593 oligomer interface [polypeptide binding]; other site 1194526001594 metal binding site [ion binding]; metal-binding site 1194526001595 metal binding site [ion binding]; metal-binding site 1194526001596 putative Cl binding site [ion binding]; other site 1194526001597 aspartate ring; other site 1194526001598 basic sphincter; other site 1194526001599 hydrophobic gate; other site 1194526001600 periplasmic entrance; other site 1194526001601 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1194526001602 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1194526001603 homotetramer interface [polypeptide binding]; other site 1194526001604 FMN binding site [chemical binding]; other site 1194526001605 homodimer contacts [polypeptide binding]; other site 1194526001606 putative active site [active] 1194526001607 putative substrate binding site [chemical binding]; other site 1194526001608 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1194526001609 Predicted transcriptional regulators [Transcription]; Region: COG1695 1194526001610 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1194526001611 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1194526001612 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1194526001613 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1194526001614 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1194526001615 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1194526001616 active site 1194526001617 DNA binding site [nucleotide binding] 1194526001618 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1194526001619 ribulokinase; Provisional; Region: PRK04123 1194526001620 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1194526001621 N- and C-terminal domain interface [polypeptide binding]; other site 1194526001622 active site 1194526001623 MgATP binding site [chemical binding]; other site 1194526001624 catalytic site [active] 1194526001625 metal binding site [ion binding]; metal-binding site 1194526001626 carbohydrate binding site [chemical binding]; other site 1194526001627 homodimer interface [polypeptide binding]; other site 1194526001628 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1194526001629 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1194526001630 Walker A/P-loop; other site 1194526001631 ATP binding site [chemical binding]; other site 1194526001632 Q-loop/lid; other site 1194526001633 ABC transporter signature motif; other site 1194526001634 Walker B; other site 1194526001635 D-loop; other site 1194526001636 H-loop/switch region; other site 1194526001637 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1194526001638 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1194526001639 hypothetical protein; Provisional; Region: PRK02237 1194526001640 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1194526001641 active site 1194526001642 catalytic residues [active] 1194526001643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1194526001644 MOSC domain; Region: MOSC; pfam03473 1194526001645 3-alpha domain; Region: 3-alpha; pfam03475 1194526001646 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1194526001647 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1194526001648 active site 1194526001649 dimer interface [polypeptide binding]; other site 1194526001650 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1194526001651 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1194526001652 CAAX protease self-immunity; Region: Abi; pfam02517 1194526001653 formimidoylglutamase; Provisional; Region: PRK13775 1194526001654 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1194526001655 putative active site [active] 1194526001656 putative metal binding site [ion binding]; other site 1194526001657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1194526001658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1194526001659 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1194526001660 dimerization interface [polypeptide binding]; other site 1194526001661 urocanate hydratase; Provisional; Region: PRK05414 1194526001662 imidazolonepropionase; Validated; Region: PRK09356 1194526001663 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1194526001664 active site 1194526001665 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1194526001666 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1194526001667 metal binding site [ion binding]; metal-binding site 1194526001668 dimer interface [polypeptide binding]; other site 1194526001669 oxidoreductase; Provisional; Region: PRK07985 1194526001670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526001671 NAD(P) binding site [chemical binding]; other site 1194526001672 active site 1194526001673 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1194526001674 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1194526001675 putative hydrophobic ligand binding site [chemical binding]; other site 1194526001676 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1194526001677 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1194526001678 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1194526001679 putative active site [active] 1194526001680 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1194526001681 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1194526001682 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1194526001683 active site turn [active] 1194526001684 phosphorylation site [posttranslational modification] 1194526001685 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1194526001686 Sodium Bile acid symporter family; Region: SBF; pfam01758 1194526001687 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1194526001688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526001689 active site 1194526001690 motif I; other site 1194526001691 motif II; other site 1194526001692 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1194526001693 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1194526001694 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1194526001695 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1194526001696 putative active site [active] 1194526001697 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1194526001698 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1194526001699 active site turn [active] 1194526001700 phosphorylation site [posttranslational modification] 1194526001701 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1194526001702 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1194526001703 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1194526001704 putative active site [active] 1194526001705 CAAX protease self-immunity; Region: Abi; pfam02517 1194526001706 Predicted transcriptional regulator [Transcription]; Region: COG2378 1194526001707 HTH domain; Region: HTH_11; pfam08279 1194526001708 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1194526001709 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1194526001710 active site 1194526001711 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1194526001712 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1194526001713 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1194526001714 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1194526001715 4Fe-4S binding domain; Region: Fer4; cl02805 1194526001716 4Fe-4S binding domain; Region: Fer4; pfam00037 1194526001717 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1194526001718 [4Fe-4S] binding site [ion binding]; other site 1194526001719 molybdopterin cofactor binding site; other site 1194526001720 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1194526001721 molybdopterin cofactor binding site; other site 1194526001722 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1194526001723 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1194526001724 Lysozyme subfamily 2; Region: LYZ2; smart00047 1194526001725 hypothetical protein; Provisional; Region: PRK06753 1194526001726 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1194526001727 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1194526001728 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1194526001729 putative ligand binding site [chemical binding]; other site 1194526001730 putative NAD binding site [chemical binding]; other site 1194526001731 catalytic site [active] 1194526001732 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1194526001733 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1194526001734 Surface antigen [General function prediction only]; Region: COG3942 1194526001735 CHAP domain; Region: CHAP; pfam05257 1194526001736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1194526001737 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1194526001738 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1194526001739 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1194526001740 Surface antigen [General function prediction only]; Region: COG3942 1194526001741 CHAP domain; Region: CHAP; pfam05257 1194526001742 Helix-turn-helix domain; Region: HTH_18; pfam12833 1194526001743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1194526001744 MarR family; Region: MarR_2; cl17246 1194526001745 MarR family; Region: MarR_2; cl17246 1194526001746 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1194526001747 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1194526001748 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1194526001749 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1194526001750 UreF; Region: UreF; pfam01730 1194526001751 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1194526001752 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1194526001753 dimer interface [polypeptide binding]; other site 1194526001754 catalytic residues [active] 1194526001755 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1194526001756 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1194526001757 subunit interactions [polypeptide binding]; other site 1194526001758 active site 1194526001759 flap region; other site 1194526001760 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1194526001761 gamma-beta subunit interface [polypeptide binding]; other site 1194526001762 alpha-beta subunit interface [polypeptide binding]; other site 1194526001763 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1194526001764 alpha-gamma subunit interface [polypeptide binding]; other site 1194526001765 beta-gamma subunit interface [polypeptide binding]; other site 1194526001766 Urea transporter; Region: UT; cl01829 1194526001767 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1194526001768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526001769 dimer interface [polypeptide binding]; other site 1194526001770 conserved gate region; other site 1194526001771 putative PBP binding loops; other site 1194526001772 ABC-ATPase subunit interface; other site 1194526001773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526001774 putative PBP binding loops; other site 1194526001775 dimer interface [polypeptide binding]; other site 1194526001776 ABC-ATPase subunit interface; other site 1194526001777 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1194526001778 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1194526001779 substrate binding pocket [chemical binding]; other site 1194526001780 membrane-bound complex binding site; other site 1194526001781 hinge residues; other site 1194526001782 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1194526001783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526001784 Walker A/P-loop; other site 1194526001785 ATP binding site [chemical binding]; other site 1194526001786 Q-loop/lid; other site 1194526001787 ABC transporter signature motif; other site 1194526001788 Walker B; other site 1194526001789 D-loop; other site 1194526001790 H-loop/switch region; other site 1194526001791 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1194526001792 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1194526001793 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1194526001794 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1194526001795 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1194526001796 intersubunit interface [polypeptide binding]; other site 1194526001797 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1194526001798 active site 1194526001799 dimerization interface [polypeptide binding]; other site 1194526001800 BioY family; Region: BioY; pfam02632 1194526001801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526001802 Coenzyme A binding pocket [chemical binding]; other site 1194526001803 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1194526001804 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1194526001805 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1194526001806 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1194526001807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526001808 dimer interface [polypeptide binding]; other site 1194526001809 conserved gate region; other site 1194526001810 putative PBP binding loops; other site 1194526001811 ABC-ATPase subunit interface; other site 1194526001812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526001813 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1194526001814 Walker A/P-loop; other site 1194526001815 ATP binding site [chemical binding]; other site 1194526001816 Q-loop/lid; other site 1194526001817 ABC transporter signature motif; other site 1194526001818 Walker B; other site 1194526001819 D-loop; other site 1194526001820 H-loop/switch region; other site 1194526001821 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1194526001822 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1194526001823 ATP binding site [chemical binding]; other site 1194526001824 substrate interface [chemical binding]; other site 1194526001825 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1194526001826 MPT binding site; other site 1194526001827 trimer interface [polypeptide binding]; other site 1194526001828 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1194526001829 trimer interface [polypeptide binding]; other site 1194526001830 dimer interface [polypeptide binding]; other site 1194526001831 putative active site [active] 1194526001832 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1194526001833 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1194526001834 dimer interface [polypeptide binding]; other site 1194526001835 putative functional site; other site 1194526001836 putative MPT binding site; other site 1194526001837 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1194526001838 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1194526001839 MoaE homodimer interface [polypeptide binding]; other site 1194526001840 MoaD interaction [polypeptide binding]; other site 1194526001841 active site residues [active] 1194526001842 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1194526001843 MoaE interaction surface [polypeptide binding]; other site 1194526001844 MoeB interaction surface [polypeptide binding]; other site 1194526001845 thiocarboxylated glycine; other site 1194526001846 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1194526001847 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1194526001848 GTP binding site; other site 1194526001849 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1194526001850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1194526001851 FeS/SAM binding site; other site 1194526001852 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1194526001853 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1194526001854 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1194526001855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526001856 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526001857 putative substrate translocation pore; other site 1194526001858 MarR family; Region: MarR_2; cl17246 1194526001859 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1194526001860 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1194526001861 FemAB family; Region: FemAB; pfam02388 1194526001862 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1194526001863 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1194526001864 Protein export membrane protein; Region: SecD_SecF; cl14618 1194526001865 Protein export membrane protein; Region: SecD_SecF; cl14618 1194526001866 Predicted permeases [General function prediction only]; Region: COG0679 1194526001867 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1194526001868 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1194526001869 NAD binding site [chemical binding]; other site 1194526001870 homodimer interface [polypeptide binding]; other site 1194526001871 active site 1194526001872 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1194526001873 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1194526001874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1194526001875 DNA topoisomerase III; Provisional; Region: PRK07726 1194526001876 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1194526001877 active site 1194526001878 putative interdomain interaction site [polypeptide binding]; other site 1194526001879 putative metal-binding site [ion binding]; other site 1194526001880 putative nucleotide binding site [chemical binding]; other site 1194526001881 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1194526001882 domain I; other site 1194526001883 DNA binding groove [nucleotide binding] 1194526001884 phosphate binding site [ion binding]; other site 1194526001885 domain II; other site 1194526001886 domain III; other site 1194526001887 nucleotide binding site [chemical binding]; other site 1194526001888 catalytic site [active] 1194526001889 domain IV; other site 1194526001890 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1194526001891 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1194526001892 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1194526001893 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1194526001894 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1194526001895 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1194526001896 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1194526001897 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1194526001898 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1194526001899 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1194526001900 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1194526001901 putative translocon binding site; other site 1194526001902 protein-rRNA interface [nucleotide binding]; other site 1194526001903 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1194526001904 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1194526001905 G-X-X-G motif; other site 1194526001906 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1194526001907 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1194526001908 23S rRNA interface [nucleotide binding]; other site 1194526001909 5S rRNA interface [nucleotide binding]; other site 1194526001910 putative antibiotic binding site [chemical binding]; other site 1194526001911 L25 interface [polypeptide binding]; other site 1194526001912 L27 interface [polypeptide binding]; other site 1194526001913 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1194526001914 23S rRNA interface [nucleotide binding]; other site 1194526001915 putative translocon interaction site; other site 1194526001916 signal recognition particle (SRP54) interaction site; other site 1194526001917 L23 interface [polypeptide binding]; other site 1194526001918 trigger factor interaction site; other site 1194526001919 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1194526001920 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1194526001921 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1194526001922 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1194526001923 RNA binding site [nucleotide binding]; other site 1194526001924 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1194526001925 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1194526001926 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1194526001927 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1194526001928 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1194526001929 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1194526001930 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1194526001931 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1194526001932 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1194526001933 5S rRNA interface [nucleotide binding]; other site 1194526001934 L27 interface [polypeptide binding]; other site 1194526001935 23S rRNA interface [nucleotide binding]; other site 1194526001936 L5 interface [polypeptide binding]; other site 1194526001937 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1194526001938 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1194526001939 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1194526001940 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1194526001941 23S rRNA binding site [nucleotide binding]; other site 1194526001942 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1194526001943 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1194526001944 SecY translocase; Region: SecY; pfam00344 1194526001945 adenylate kinase; Reviewed; Region: adk; PRK00279 1194526001946 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1194526001947 AMP-binding site [chemical binding]; other site 1194526001948 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1194526001949 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1194526001950 rRNA binding site [nucleotide binding]; other site 1194526001951 predicted 30S ribosome binding site; other site 1194526001952 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1194526001953 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1194526001954 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1194526001955 30S ribosomal protein S11; Validated; Region: PRK05309 1194526001956 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1194526001957 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1194526001958 alphaNTD homodimer interface [polypeptide binding]; other site 1194526001959 alphaNTD - beta interaction site [polypeptide binding]; other site 1194526001960 alphaNTD - beta' interaction site [polypeptide binding]; other site 1194526001961 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1194526001962 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1194526001963 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1194526001964 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1194526001965 Walker A/P-loop; other site 1194526001966 ATP binding site [chemical binding]; other site 1194526001967 Q-loop/lid; other site 1194526001968 ABC transporter signature motif; other site 1194526001969 Walker B; other site 1194526001970 D-loop; other site 1194526001971 H-loop/switch region; other site 1194526001972 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1194526001973 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1194526001974 Walker A/P-loop; other site 1194526001975 ATP binding site [chemical binding]; other site 1194526001976 Q-loop/lid; other site 1194526001977 ABC transporter signature motif; other site 1194526001978 Walker B; other site 1194526001979 D-loop; other site 1194526001980 H-loop/switch region; other site 1194526001981 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1194526001982 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1194526001983 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1194526001984 dimerization interface 3.5A [polypeptide binding]; other site 1194526001985 active site 1194526001986 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1194526001987 23S rRNA interface [nucleotide binding]; other site 1194526001988 L3 interface [polypeptide binding]; other site 1194526001989 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1194526001990 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1194526001991 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1194526001992 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1194526001993 DNA binding residues [nucleotide binding] 1194526001994 dimer interface [polypeptide binding]; other site 1194526001995 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1194526001996 NAD-dependent deacetylase; Provisional; Region: PRK00481 1194526001997 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1194526001998 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1194526001999 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1194526002000 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1194526002001 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1194526002002 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1194526002003 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1194526002004 putative substrate binding site [chemical binding]; other site 1194526002005 putative ATP binding site [chemical binding]; other site 1194526002006 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1194526002007 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1194526002008 methionine cluster; other site 1194526002009 active site 1194526002010 phosphorylation site [posttranslational modification] 1194526002011 metal binding site [ion binding]; metal-binding site 1194526002012 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1194526002013 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1194526002014 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1194526002015 active site 1194526002016 P-loop; other site 1194526002017 phosphorylation site [posttranslational modification] 1194526002018 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1194526002019 beta-galactosidase; Region: BGL; TIGR03356 1194526002020 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1194526002021 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1194526002022 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1194526002023 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1194526002024 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1194526002025 NAD(P) binding site [chemical binding]; other site 1194526002026 substrate binding site [chemical binding]; other site 1194526002027 dimer interface [polypeptide binding]; other site 1194526002028 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1194526002029 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1194526002030 putative NAD(P) binding site [chemical binding]; other site 1194526002031 dimer interface [polypeptide binding]; other site 1194526002032 BCCT family transporter; Region: BCCT; pfam02028 1194526002033 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 1194526002034 Asp23 family; Region: Asp23; pfam03780 1194526002035 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1194526002036 IucA / IucC family; Region: IucA_IucC; pfam04183 1194526002037 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1194526002038 H+ Antiporter protein; Region: 2A0121; TIGR00900 1194526002039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526002040 putative substrate translocation pore; other site 1194526002041 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1194526002042 IucA / IucC family; Region: IucA_IucC; pfam04183 1194526002043 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1194526002044 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1194526002045 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1194526002046 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1194526002047 catalytic residue [active] 1194526002048 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1194526002049 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1194526002050 siderophore binding site; other site 1194526002051 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1194526002052 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1194526002053 ABC-ATPase subunit interface; other site 1194526002054 dimer interface [polypeptide binding]; other site 1194526002055 putative PBP binding regions; other site 1194526002056 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1194526002057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1194526002058 ABC-ATPase subunit interface; other site 1194526002059 dimer interface [polypeptide binding]; other site 1194526002060 putative PBP binding regions; other site 1194526002061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1194526002062 Nucleoside recognition; Region: Gate; pfam07670 1194526002063 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13315 1194526002064 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1194526002065 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1194526002066 substrate binding site; other site 1194526002067 dimerization interface; other site 1194526002068 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1194526002069 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1194526002070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526002071 putative substrate translocation pore; other site 1194526002072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526002073 potential frameshift: common BLAST hit: gi|57867671|ref|YP_189330.1| EmrB/QacA family drug resistance transporter 1194526002074 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 1194526002075 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1194526002076 Walker A motif; other site 1194526002077 Arginase family; Region: Arginase; cd09989 1194526002078 agmatinase; Region: agmatinase; TIGR01230 1194526002079 active site 1194526002080 Mn binding site [ion binding]; other site 1194526002081 oligomer interface [polypeptide binding]; other site 1194526002082 TIGR00159 family protein; Region: TIGR00159 1194526002083 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1194526002084 YbbR-like protein; Region: YbbR; pfam07949 1194526002085 YbbR-like protein; Region: YbbR; pfam07949 1194526002086 YbbR-like protein; Region: YbbR; pfam07949 1194526002087 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1194526002088 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1194526002089 active site 1194526002090 substrate binding site [chemical binding]; other site 1194526002091 metal binding site [ion binding]; metal-binding site 1194526002092 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1194526002093 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1194526002094 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1194526002095 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1194526002096 active site 1194526002097 phosphorylation site [posttranslational modification] 1194526002098 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1194526002099 HTH domain; Region: HTH_11; pfam08279 1194526002100 PRD domain; Region: PRD; pfam00874 1194526002101 PRD domain; Region: PRD; pfam00874 1194526002102 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1194526002103 active site 1194526002104 P-loop; other site 1194526002105 phosphorylation site [posttranslational modification] 1194526002106 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1194526002107 active site 1194526002108 phosphorylation site [posttranslational modification] 1194526002109 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1194526002110 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1194526002111 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1194526002112 active site 1194526002113 P-loop; other site 1194526002114 phosphorylation site [posttranslational modification] 1194526002115 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1194526002116 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1194526002117 glutaminase active site [active] 1194526002118 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1194526002119 dimer interface [polypeptide binding]; other site 1194526002120 active site 1194526002121 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1194526002122 dimer interface [polypeptide binding]; other site 1194526002123 active site 1194526002124 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1194526002125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526002126 active site 1194526002127 motif I; other site 1194526002128 motif II; other site 1194526002129 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1194526002130 Protein of unknown function (DUF975); Region: DUF975; cl10504 1194526002131 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1194526002132 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1194526002133 active site 1194526002134 metal binding site [ion binding]; metal-binding site 1194526002135 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1194526002136 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1194526002137 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1194526002138 dimerization interface [polypeptide binding]; other site 1194526002139 putative DNA binding site [nucleotide binding]; other site 1194526002140 putative Zn2+ binding site [ion binding]; other site 1194526002141 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1194526002142 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1194526002143 NAD(P) binding site [chemical binding]; other site 1194526002144 putative active site [active] 1194526002145 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1194526002146 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1194526002147 EVE domain; Region: EVE; cl00728 1194526002148 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1194526002149 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1194526002150 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1194526002151 dimerization interface [polypeptide binding]; other site 1194526002152 DPS ferroxidase diiron center [ion binding]; other site 1194526002153 ion pore; other site 1194526002154 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1194526002155 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1194526002156 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1194526002157 intersubunit interface [polypeptide binding]; other site 1194526002158 active site 1194526002159 catalytic residue [active] 1194526002160 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1194526002161 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1194526002162 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1194526002163 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1194526002164 phosphopentomutase; Provisional; Region: PRK05362 1194526002165 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1194526002166 Predicted membrane protein [Function unknown]; Region: COG4270 1194526002167 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1194526002168 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1194526002169 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1194526002170 metal binding site [ion binding]; metal-binding site 1194526002171 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1194526002172 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1194526002173 pantothenate kinase; Provisional; Region: PRK13317 1194526002174 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1194526002175 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1194526002176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526002177 Coenzyme A binding pocket [chemical binding]; other site 1194526002178 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1194526002179 CTP synthetase; Validated; Region: pyrG; PRK05380 1194526002180 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1194526002181 Catalytic site [active] 1194526002182 active site 1194526002183 UTP binding site [chemical binding]; other site 1194526002184 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1194526002185 active site 1194526002186 putative oxyanion hole; other site 1194526002187 catalytic triad [active] 1194526002188 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1194526002189 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1194526002190 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1194526002191 intersubunit interface [polypeptide binding]; other site 1194526002192 active site 1194526002193 zinc binding site [ion binding]; other site 1194526002194 Na+ binding site [ion binding]; other site 1194526002195 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1194526002196 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1194526002197 hinge; other site 1194526002198 active site 1194526002199 Predicted transcriptional regulators [Transcription]; Region: COG1733 1194526002200 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1194526002201 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1194526002202 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1194526002203 NAD binding site [chemical binding]; other site 1194526002204 catalytic residues [active] 1194526002205 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1194526002206 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1194526002207 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1194526002208 RNA binding site [nucleotide binding]; other site 1194526002209 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1194526002210 Walker A motif; other site 1194526002211 ATP binding site [chemical binding]; other site 1194526002212 Walker B motif; other site 1194526002213 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1194526002214 thymidine kinase; Provisional; Region: PRK04296 1194526002215 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1194526002216 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1194526002217 RF-1 domain; Region: RF-1; pfam00472 1194526002218 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1194526002219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526002220 S-adenosylmethionine binding site [chemical binding]; other site 1194526002221 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1194526002222 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1194526002223 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1194526002224 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1194526002225 active site 1194526002226 hypothetical protein; Provisional; Region: PRK13690 1194526002227 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1194526002228 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1194526002229 dimer interface [polypeptide binding]; other site 1194526002230 active site 1194526002231 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1194526002232 folate binding site [chemical binding]; other site 1194526002233 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526002234 active site 1194526002235 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1194526002236 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1194526002237 active site 1194526002238 homodimer interface [polypeptide binding]; other site 1194526002239 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1194526002240 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1194526002241 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1194526002242 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1194526002243 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1194526002244 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1194526002245 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1194526002246 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1194526002247 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1194526002248 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1194526002249 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1194526002250 beta subunit interaction interface [polypeptide binding]; other site 1194526002251 Walker A motif; other site 1194526002252 ATP binding site [chemical binding]; other site 1194526002253 Walker B motif; other site 1194526002254 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1194526002255 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1194526002256 core domain interface [polypeptide binding]; other site 1194526002257 delta subunit interface [polypeptide binding]; other site 1194526002258 epsilon subunit interface [polypeptide binding]; other site 1194526002259 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1194526002260 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1194526002261 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1194526002262 alpha subunit interaction interface [polypeptide binding]; other site 1194526002263 Walker A motif; other site 1194526002264 ATP binding site [chemical binding]; other site 1194526002265 Walker B motif; other site 1194526002266 inhibitor binding site; inhibition site 1194526002267 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1194526002268 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1194526002269 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1194526002270 gamma subunit interface [polypeptide binding]; other site 1194526002271 epsilon subunit interface [polypeptide binding]; other site 1194526002272 LBP interface [polypeptide binding]; other site 1194526002273 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1194526002274 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1194526002275 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1194526002276 hinge; other site 1194526002277 active site 1194526002278 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1194526002279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1194526002280 YwpF-like protein; Region: YwpF; pfam14183 1194526002281 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1194526002282 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1194526002283 dimer interface [polypeptide binding]; other site 1194526002284 ssDNA binding site [nucleotide binding]; other site 1194526002285 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1194526002286 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1194526002287 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1194526002288 catalytic residue [active] 1194526002289 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1194526002290 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1194526002291 dimer interface [polypeptide binding]; other site 1194526002292 substrate binding site [chemical binding]; other site 1194526002293 ATP binding site [chemical binding]; other site 1194526002294 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1194526002295 substrate binding site [chemical binding]; other site 1194526002296 multimerization interface [polypeptide binding]; other site 1194526002297 ATP binding site [chemical binding]; other site 1194526002298 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1194526002299 thiamine phosphate binding site [chemical binding]; other site 1194526002300 active site 1194526002301 pyrophosphate binding site [ion binding]; other site 1194526002302 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1194526002303 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1194526002304 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1194526002305 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1194526002306 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1194526002307 putative active site [active] 1194526002308 catalytic site [active] 1194526002309 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1194526002310 putative active site [active] 1194526002311 catalytic site [active] 1194526002312 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1194526002313 putative homodimer interface [polypeptide binding]; other site 1194526002314 putative homotetramer interface [polypeptide binding]; other site 1194526002315 allosteric switch controlling residues; other site 1194526002316 putative metal binding site [ion binding]; other site 1194526002317 putative homodimer-homodimer interface [polypeptide binding]; other site 1194526002318 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1194526002319 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1194526002320 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1194526002321 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1194526002322 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1194526002323 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1194526002324 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1194526002325 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1194526002326 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1194526002327 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1194526002328 ATP binding site [chemical binding]; other site 1194526002329 Mg++ binding site [ion binding]; other site 1194526002330 motif III; other site 1194526002331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526002332 nucleotide binding region [chemical binding]; other site 1194526002333 ATP-binding site [chemical binding]; other site 1194526002334 Bacterial PH domain; Region: DUF304; pfam03703 1194526002335 Predicted membrane protein [Function unknown]; Region: COG3428 1194526002336 Bacterial PH domain; Region: DUF304; pfam03703 1194526002337 Bacterial PH domain; Region: DUF304; pfam03703 1194526002338 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1194526002339 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1194526002340 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1194526002341 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1194526002342 active site 1194526002343 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1194526002344 dimer interface [polypeptide binding]; other site 1194526002345 substrate binding site [chemical binding]; other site 1194526002346 catalytic residues [active] 1194526002347 PemK-like protein; Region: PemK; pfam02452 1194526002348 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1194526002349 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1194526002350 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1194526002351 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1194526002352 anti sigma factor interaction site; other site 1194526002353 regulatory phosphorylation site [posttranslational modification]; other site 1194526002354 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1194526002355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526002356 ATP binding site [chemical binding]; other site 1194526002357 Mg2+ binding site [ion binding]; other site 1194526002358 G-X-G motif; other site 1194526002359 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1194526002360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1194526002361 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1194526002362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1194526002363 DNA binding residues [nucleotide binding] 1194526002364 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1194526002365 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1194526002366 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1194526002367 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1194526002368 RNA binding site [nucleotide binding]; other site 1194526002369 hypothetical protein; Provisional; Region: PRK04351 1194526002370 SprT homologues; Region: SprT; cl01182 1194526002371 threonine dehydratase; Validated; Region: PRK08639 1194526002372 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1194526002373 tetramer interface [polypeptide binding]; other site 1194526002374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526002375 catalytic residue [active] 1194526002376 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1194526002377 putative Ile/Val binding site [chemical binding]; other site 1194526002378 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1194526002379 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1194526002380 substrate binding site [chemical binding]; other site 1194526002381 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1194526002382 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1194526002383 substrate binding site [chemical binding]; other site 1194526002384 ligand binding site [chemical binding]; other site 1194526002385 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1194526002386 tartrate dehydrogenase; Region: TTC; TIGR02089 1194526002387 2-isopropylmalate synthase; Validated; Region: PRK00915 1194526002388 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1194526002389 active site 1194526002390 catalytic residues [active] 1194526002391 metal binding site [ion binding]; metal-binding site 1194526002392 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1194526002393 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1194526002394 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1194526002395 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1194526002396 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1194526002397 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1194526002398 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1194526002399 PYR/PP interface [polypeptide binding]; other site 1194526002400 dimer interface [polypeptide binding]; other site 1194526002401 TPP binding site [chemical binding]; other site 1194526002402 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1194526002403 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1194526002404 TPP-binding site [chemical binding]; other site 1194526002405 dimer interface [polypeptide binding]; other site 1194526002406 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1194526002407 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1194526002408 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1194526002409 Glycoprotease family; Region: Peptidase_M22; pfam00814 1194526002410 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1194526002411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526002412 Coenzyme A binding pocket [chemical binding]; other site 1194526002413 UGMP family protein; Validated; Region: PRK09604 1194526002414 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1194526002415 potential frameshift: common BLAST hit: gi|289550329|ref|YP_003471233.1| MutS-related protein, family 1 1194526002416 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1194526002417 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1194526002418 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1194526002419 ABC transporter; Region: ABC_tran_2; pfam12848 1194526002420 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1194526002421 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1194526002422 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1194526002423 CoA binding domain; Region: CoA_binding; pfam02629 1194526002424 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1194526002425 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1194526002426 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1194526002427 CPxP motif; other site 1194526002428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1194526002429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1194526002430 DNA binding site [nucleotide binding] 1194526002431 domain linker motif; other site 1194526002432 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1194526002433 dimerization interface [polypeptide binding]; other site 1194526002434 ligand binding site [chemical binding]; other site 1194526002435 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1194526002436 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1194526002437 substrate binding [chemical binding]; other site 1194526002438 active site 1194526002439 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1194526002440 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1194526002441 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1194526002442 putative substrate binding site [chemical binding]; other site 1194526002443 putative ATP binding site [chemical binding]; other site 1194526002444 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1194526002445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526002446 active site 1194526002447 phosphorylation site [posttranslational modification] 1194526002448 intermolecular recognition site; other site 1194526002449 dimerization interface [polypeptide binding]; other site 1194526002450 LytTr DNA-binding domain; Region: LytTR; pfam04397 1194526002451 Srg family chemoreceptor; Region: Srg; pfam02118 1194526002452 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1194526002453 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1194526002454 Staphylococcal AgrD protein; Region: AgrD; smart00794 1194526002455 Accessory gene regulator B; Region: AgrB; smart00793 1194526002456 Delta lysin family; Region: Delta_lysin; pfam05372 1194526002457 Delta lysin family; Region: Delta_lysin; pfam05372 1194526002458 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1194526002459 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1194526002460 putative active site [active] 1194526002461 catalytic triad [active] 1194526002462 putative dimer interface [polypeptide binding]; other site 1194526002463 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1194526002464 dimer interface [polypeptide binding]; other site 1194526002465 FMN binding site [chemical binding]; other site 1194526002466 CAAX protease self-immunity; Region: Abi; pfam02517 1194526002467 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1194526002468 oligomerisation interface [polypeptide binding]; other site 1194526002469 mobile loop; other site 1194526002470 roof hairpin; other site 1194526002471 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1194526002472 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1194526002473 ring oligomerisation interface [polypeptide binding]; other site 1194526002474 ATP/Mg binding site [chemical binding]; other site 1194526002475 stacking interactions; other site 1194526002476 hinge regions; other site 1194526002477 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 1194526002478 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1194526002479 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1194526002480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1194526002481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526002482 homodimer interface [polypeptide binding]; other site 1194526002483 catalytic residue [active] 1194526002484 Predicted transcriptional regulators [Transcription]; Region: COG1725 1194526002485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1194526002486 DNA-binding site [nucleotide binding]; DNA binding site 1194526002487 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1194526002488 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1194526002489 Walker A/P-loop; other site 1194526002490 ATP binding site [chemical binding]; other site 1194526002491 Q-loop/lid; other site 1194526002492 ABC transporter signature motif; other site 1194526002493 Walker B; other site 1194526002494 D-loop; other site 1194526002495 H-loop/switch region; other site 1194526002496 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1194526002497 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1194526002498 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1194526002499 Walker A/P-loop; other site 1194526002500 ATP binding site [chemical binding]; other site 1194526002501 Q-loop/lid; other site 1194526002502 ABC transporter signature motif; other site 1194526002503 Walker B; other site 1194526002504 D-loop; other site 1194526002505 H-loop/switch region; other site 1194526002506 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1194526002507 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 1194526002508 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1194526002509 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1194526002510 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1194526002511 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1194526002512 active site 1194526002513 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1194526002514 YolD-like protein; Region: YolD; pfam08863 1194526002515 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1194526002516 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1194526002517 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1194526002518 NAD(P) binding site [chemical binding]; other site 1194526002519 catalytic residues [active] 1194526002520 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1194526002521 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1194526002522 DHHA2 domain; Region: DHHA2; pfam02833 1194526002523 Isochorismatase family; Region: Isochorismatase; pfam00857 1194526002524 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1194526002525 catalytic triad [active] 1194526002526 conserved cis-peptide bond; other site 1194526002527 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1194526002528 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1194526002529 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1194526002530 Prephenate dehydratase; Region: PDT; pfam00800 1194526002531 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1194526002532 putative L-Phe binding site [chemical binding]; other site 1194526002533 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1194526002534 active site 1194526002535 dimer interface [polypeptide binding]; other site 1194526002536 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1194526002537 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1194526002538 active site 1194526002539 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1194526002540 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1194526002541 homodimer interface [polypeptide binding]; other site 1194526002542 NAD binding pocket [chemical binding]; other site 1194526002543 ATP binding pocket [chemical binding]; other site 1194526002544 Mg binding site [ion binding]; other site 1194526002545 active-site loop [active] 1194526002546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1194526002547 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1194526002548 NETI protein; Region: NETI; pfam14044 1194526002549 adenylosuccinate lyase; Provisional; Region: PRK07492 1194526002550 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1194526002551 tetramer interface [polypeptide binding]; other site 1194526002552 active site 1194526002553 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1194526002554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1194526002555 PcrB family; Region: PcrB; pfam01884 1194526002556 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1194526002557 substrate binding site [chemical binding]; other site 1194526002558 putative active site [active] 1194526002559 dimer interface [polypeptide binding]; other site 1194526002560 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1194526002561 Part of AAA domain; Region: AAA_19; pfam13245 1194526002562 Family description; Region: UvrD_C_2; pfam13538 1194526002563 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1194526002564 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1194526002565 nucleotide binding pocket [chemical binding]; other site 1194526002566 K-X-D-G motif; other site 1194526002567 catalytic site [active] 1194526002568 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1194526002569 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1194526002570 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1194526002571 Dimer interface [polypeptide binding]; other site 1194526002572 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1194526002573 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1194526002574 putative dimer interface [polypeptide binding]; other site 1194526002575 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1194526002576 putative dimer interface [polypeptide binding]; other site 1194526002577 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1194526002578 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1194526002579 Na binding site [ion binding]; other site 1194526002580 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1194526002581 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1194526002582 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1194526002583 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1194526002584 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1194526002585 GatB domain; Region: GatB_Yqey; pfam02637 1194526002586 putative lipid kinase; Reviewed; Region: PRK13337 1194526002587 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1194526002588 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1194526002589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526002590 S-adenosylmethionine binding site [chemical binding]; other site 1194526002591 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1194526002592 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1194526002593 active site 1194526002594 DNA polymerase IV; Validated; Region: PRK02406 1194526002595 DNA binding site [nucleotide binding] 1194526002596 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1194526002597 active site 1194526002598 catalytic site [active] 1194526002599 substrate binding site [chemical binding]; other site 1194526002600 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1194526002601 Ferritin-like domain; Region: Ferritin; pfam00210 1194526002602 ferroxidase diiron center [ion binding]; other site 1194526002603 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1194526002604 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1194526002605 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1194526002606 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1194526002607 catalytic triad [active] 1194526002608 Predicted membrane protein [Function unknown]; Region: COG4129 1194526002609 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1194526002610 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1194526002611 active site 1194526002612 Predicted membrane protein [Function unknown]; Region: COG4758 1194526002613 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1194526002614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1194526002615 Histidine kinase; Region: HisKA_3; pfam07730 1194526002616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526002617 ATP binding site [chemical binding]; other site 1194526002618 Mg2+ binding site [ion binding]; other site 1194526002619 G-X-G motif; other site 1194526002620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1194526002621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526002622 active site 1194526002623 phosphorylation site [posttranslational modification] 1194526002624 intermolecular recognition site; other site 1194526002625 dimerization interface [polypeptide binding]; other site 1194526002626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1194526002627 DNA binding residues [nucleotide binding] 1194526002628 dimerization interface [polypeptide binding]; other site 1194526002629 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1194526002630 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1194526002631 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1194526002632 active site 1194526002633 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1194526002634 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1194526002635 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1194526002636 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1194526002637 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1194526002638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1194526002639 FeS/SAM binding site; other site 1194526002640 YfkB-like domain; Region: YfkB; pfam08756 1194526002641 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1194526002642 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1194526002643 proposed catalytic triad [active] 1194526002644 conserved cys residue [active] 1194526002645 glycosyltransferase; Provisional; Region: PRK13481 1194526002646 Transglycosylase; Region: Transgly; pfam00912 1194526002647 recombination regulator RecX; Provisional; Region: recX; PRK14135 1194526002648 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1194526002649 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1194526002650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526002651 Walker A/P-loop; other site 1194526002652 ATP binding site [chemical binding]; other site 1194526002653 ABC transporter signature motif; other site 1194526002654 Walker B; other site 1194526002655 D-loop; other site 1194526002656 H-loop/switch region; other site 1194526002657 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1194526002658 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1194526002659 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1194526002660 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1194526002661 minor groove reading motif; other site 1194526002662 helix-hairpin-helix signature motif; other site 1194526002663 substrate binding pocket [chemical binding]; other site 1194526002664 active site 1194526002665 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1194526002666 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1194526002667 DNA binding and oxoG recognition site [nucleotide binding] 1194526002668 hypothetical protein; Provisional; Region: PRK13662 1194526002669 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1194526002670 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1194526002671 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1194526002672 Walker A/P-loop; other site 1194526002673 ATP binding site [chemical binding]; other site 1194526002674 Q-loop/lid; other site 1194526002675 ABC transporter signature motif; other site 1194526002676 Walker B; other site 1194526002677 D-loop; other site 1194526002678 H-loop/switch region; other site 1194526002679 Predicted membrane protein [Function unknown]; Region: COG4129 1194526002680 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1194526002681 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1194526002682 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1194526002683 inhibitor-cofactor binding pocket; inhibition site 1194526002684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526002685 catalytic residue [active] 1194526002686 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1194526002687 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1194526002688 catalytic triad [active] 1194526002689 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1194526002690 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1194526002691 putative ligand binding site [chemical binding]; other site 1194526002692 NAD binding site [chemical binding]; other site 1194526002693 catalytic site [active] 1194526002694 ferric uptake regulator; Provisional; Region: fur; PRK09462 1194526002695 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1194526002696 metal binding site 2 [ion binding]; metal-binding site 1194526002697 putative DNA binding helix; other site 1194526002698 metal binding site 1 [ion binding]; metal-binding site 1194526002699 dimer interface [polypeptide binding]; other site 1194526002700 structural Zn2+ binding site [ion binding]; other site 1194526002701 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1194526002702 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1194526002703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1194526002704 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1194526002705 substrate binding pocket [chemical binding]; other site 1194526002706 membrane-bound complex binding site; other site 1194526002707 hinge residues; other site 1194526002708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526002709 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1194526002710 dimer interface [polypeptide binding]; other site 1194526002711 conserved gate region; other site 1194526002712 putative PBP binding loops; other site 1194526002713 ABC-ATPase subunit interface; other site 1194526002714 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1194526002715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526002716 Walker A/P-loop; other site 1194526002717 ATP binding site [chemical binding]; other site 1194526002718 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1194526002719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526002720 ABC transporter signature motif; other site 1194526002721 Walker B; other site 1194526002722 D-loop; other site 1194526002723 H-loop/switch region; other site 1194526002724 epoxyqueuosine reductase; Region: TIGR00276 1194526002725 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1194526002726 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1194526002727 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1194526002728 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1194526002729 active site 1194526002730 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1194526002731 Class II fumarases; Region: Fumarase_classII; cd01362 1194526002732 active site 1194526002733 tetramer interface [polypeptide binding]; other site 1194526002734 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1194526002735 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1194526002736 active site 1194526002737 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1194526002738 GAF domain; Region: GAF_3; pfam13492 1194526002739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1194526002740 Histidine kinase; Region: HisKA_3; pfam07730 1194526002741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526002742 ATP binding site [chemical binding]; other site 1194526002743 Mg2+ binding site [ion binding]; other site 1194526002744 G-X-G motif; other site 1194526002745 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1194526002746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526002747 active site 1194526002748 phosphorylation site [posttranslational modification] 1194526002749 intermolecular recognition site; other site 1194526002750 dimerization interface [polypeptide binding]; other site 1194526002751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1194526002752 DNA binding residues [nucleotide binding] 1194526002753 dimerization interface [polypeptide binding]; other site 1194526002754 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1194526002755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1194526002756 non-specific DNA binding site [nucleotide binding]; other site 1194526002757 salt bridge; other site 1194526002758 sequence-specific DNA binding site [nucleotide binding]; other site 1194526002759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1194526002760 hypothetical protein; Provisional; Region: PRK13676 1194526002761 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1194526002762 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1194526002763 active site 1194526002764 metal binding site [ion binding]; metal-binding site 1194526002765 DNA binding site [nucleotide binding] 1194526002766 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1194526002767 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1194526002768 Peptidase family M48; Region: Peptidase_M48; cl12018 1194526002769 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1194526002770 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1194526002771 generic binding surface II; other site 1194526002772 generic binding surface I; other site 1194526002773 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1194526002774 Zn2+ binding site [ion binding]; other site 1194526002775 Mg2+ binding site [ion binding]; other site 1194526002776 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1194526002777 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1194526002778 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1194526002779 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1194526002780 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1194526002781 HIT family signature motif; other site 1194526002782 catalytic residue [active] 1194526002783 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1194526002784 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1194526002785 Walker A/P-loop; other site 1194526002786 ATP binding site [chemical binding]; other site 1194526002787 Q-loop/lid; other site 1194526002788 ABC transporter signature motif; other site 1194526002789 Walker B; other site 1194526002790 D-loop; other site 1194526002791 H-loop/switch region; other site 1194526002792 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1194526002793 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1194526002794 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1194526002795 substrate binding site [chemical binding]; other site 1194526002796 active site 1194526002797 ferrochelatase; Provisional; Region: PRK12435 1194526002798 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1194526002799 C-terminal domain interface [polypeptide binding]; other site 1194526002800 active site 1194526002801 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1194526002802 active site 1194526002803 N-terminal domain interface [polypeptide binding]; other site 1194526002804 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1194526002805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1194526002806 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1194526002807 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1194526002808 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1194526002809 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1194526002810 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1194526002811 acyl-activating enzyme (AAE) consensus motif; other site 1194526002812 putative AMP binding site [chemical binding]; other site 1194526002813 putative active site [active] 1194526002814 putative CoA binding site [chemical binding]; other site 1194526002815 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1194526002816 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1194526002817 metal binding site [ion binding]; metal-binding site 1194526002818 substrate binding pocket [chemical binding]; other site 1194526002819 Haemolytic domain; Region: Haemolytic; pfam01809 1194526002820 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1194526002821 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1194526002822 nudix motif; other site 1194526002823 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1194526002824 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1194526002825 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1194526002826 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1194526002827 active site 1194526002828 substrate-binding site [chemical binding]; other site 1194526002829 metal-binding site [ion binding] 1194526002830 ATP binding site [chemical binding]; other site 1194526002831 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1194526002832 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1194526002833 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1194526002834 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1194526002835 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1194526002836 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1194526002837 active site 1194526002838 catalytic tetrad [active] 1194526002839 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1194526002840 CrcB-like protein; Region: CRCB; cl09114 1194526002841 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1194526002842 active site 1194526002843 intersubunit interactions; other site 1194526002844 catalytic residue [active] 1194526002845 ComK protein; Region: ComK; cl11560 1194526002846 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1194526002847 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1194526002848 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1194526002849 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1194526002850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1194526002851 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1194526002852 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1194526002853 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1194526002854 catalytic motif [active] 1194526002855 Zn binding site [ion binding]; other site 1194526002856 RibD C-terminal domain; Region: RibD_C; cl17279 1194526002857 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1194526002858 Lumazine binding domain; Region: Lum_binding; pfam00677 1194526002859 Lumazine binding domain; Region: Lum_binding; pfam00677 1194526002860 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1194526002861 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1194526002862 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1194526002863 dimerization interface [polypeptide binding]; other site 1194526002864 active site 1194526002865 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1194526002866 homopentamer interface [polypeptide binding]; other site 1194526002867 active site 1194526002868 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1194526002869 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1194526002870 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1194526002871 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1194526002872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526002873 S-adenosylmethionine binding site [chemical binding]; other site 1194526002874 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1194526002875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526002876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526002877 putative substrate translocation pore; other site 1194526002878 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1194526002879 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1194526002880 HIGH motif; other site 1194526002881 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1194526002882 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1194526002883 active site 1194526002884 KMSKS motif; other site 1194526002885 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1194526002886 tRNA binding surface [nucleotide binding]; other site 1194526002887 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1194526002888 active site residue [active] 1194526002889 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1194526002890 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1194526002891 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002892 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002893 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002894 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002895 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002896 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002897 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002898 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002899 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002900 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002901 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002902 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002903 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002904 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002905 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002906 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002907 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002908 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1194526002909 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002910 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002911 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002912 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002913 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002914 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002915 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526002916 HI0933-like protein; Region: HI0933_like; pfam03486 1194526002917 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1194526002918 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1194526002919 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1194526002920 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1194526002921 RNA binding surface [nucleotide binding]; other site 1194526002922 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1194526002923 active site 1194526002924 uracil binding [chemical binding]; other site 1194526002925 YtxH-like protein; Region: YtxH; pfam12732 1194526002926 dipeptidase PepV; Reviewed; Region: PRK07318 1194526002927 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1194526002928 active site 1194526002929 metal binding site [ion binding]; metal-binding site 1194526002930 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1194526002931 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1194526002932 homodimer interface [polypeptide binding]; other site 1194526002933 substrate-cofactor binding pocket; other site 1194526002934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526002935 catalytic residue [active] 1194526002936 Phosphotransferase enzyme family; Region: APH; pfam01636 1194526002937 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1194526002938 active site 1194526002939 substrate binding site [chemical binding]; other site 1194526002940 ATP binding site [chemical binding]; other site 1194526002941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526002942 S-adenosylmethionine binding site [chemical binding]; other site 1194526002943 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1194526002944 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1194526002945 Predicted small secreted protein [Function unknown]; Region: COG5584 1194526002946 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1194526002947 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1194526002948 oligomer interface [polypeptide binding]; other site 1194526002949 active site 1194526002950 metal binding site [ion binding]; metal-binding site 1194526002951 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1194526002952 catalytic residues [active] 1194526002953 hypothetical protein; Provisional; Region: PRK13668 1194526002954 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1194526002955 putative tRNA-binding site [nucleotide binding]; other site 1194526002956 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1194526002957 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1194526002958 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1194526002959 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1194526002960 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1194526002961 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1194526002962 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1194526002963 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1194526002964 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1194526002965 Chorismate mutase type II; Region: CM_2; cl00693 1194526002966 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1194526002967 catabolite control protein A; Region: ccpA; TIGR01481 1194526002968 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1194526002969 DNA binding site [nucleotide binding] 1194526002970 domain linker motif; other site 1194526002971 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1194526002972 dimerization interface [polypeptide binding]; other site 1194526002973 effector binding site; other site 1194526002974 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1194526002975 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1194526002976 active site 1194526002977 Zn binding site [ion binding]; other site 1194526002978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1194526002979 acetyl-CoA synthetase; Provisional; Region: PRK04319 1194526002980 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1194526002981 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1194526002982 active site 1194526002983 acyl-activating enzyme (AAE) consensus motif; other site 1194526002984 putative CoA binding site [chemical binding]; other site 1194526002985 AMP binding site [chemical binding]; other site 1194526002986 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1194526002987 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1194526002988 Potassium binding sites [ion binding]; other site 1194526002989 Cesium cation binding sites [ion binding]; other site 1194526002990 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1194526002991 Transglycosylase; Region: Transgly; pfam00912 1194526002992 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1194526002993 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1194526002994 active site 1194526002995 HIGH motif; other site 1194526002996 dimer interface [polypeptide binding]; other site 1194526002997 KMSKS motif; other site 1194526002998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1194526002999 RNA binding surface [nucleotide binding]; other site 1194526003000 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1194526003001 MarR family; Region: MarR; pfam01047 1194526003002 MarR family; Region: MarR_2; cl17246 1194526003003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526003004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526003005 putative substrate translocation pore; other site 1194526003006 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1194526003007 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1194526003008 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1194526003009 protein binding site [polypeptide binding]; other site 1194526003010 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1194526003011 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1194526003012 putative acyl-acceptor binding pocket; other site 1194526003013 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1194526003014 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1194526003015 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1194526003016 active site turn [active] 1194526003017 phosphorylation site [posttranslational modification] 1194526003018 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1194526003019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526003020 motif II; other site 1194526003021 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1194526003022 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1194526003023 ligand binding site [chemical binding]; other site 1194526003024 NAD binding site [chemical binding]; other site 1194526003025 dimerization interface [polypeptide binding]; other site 1194526003026 catalytic site [active] 1194526003027 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1194526003028 putative L-serine binding site [chemical binding]; other site 1194526003029 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1194526003030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1194526003031 catalytic residue [active] 1194526003032 OsmC-like protein; Region: OsmC; cl00767 1194526003033 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1194526003034 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1194526003035 active site 1194526003036 catalytic site [active] 1194526003037 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1194526003038 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1194526003039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1194526003040 RNA binding surface [nucleotide binding]; other site 1194526003041 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1194526003042 GAF domain; Region: GAF_2; pfam13185 1194526003043 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1194526003044 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1194526003045 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1194526003046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1194526003047 catalytic residue [active] 1194526003048 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1194526003049 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1194526003050 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1194526003051 Ligand Binding Site [chemical binding]; other site 1194526003052 hypothetical protein; Provisional; Region: PRK10621 1194526003053 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1194526003054 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1194526003055 dimer interface [polypeptide binding]; other site 1194526003056 catalytic triad [active] 1194526003057 peroxidatic and resolving cysteines [active] 1194526003058 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1194526003059 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1194526003060 S-adenosylmethionine binding site [chemical binding]; other site 1194526003061 propionate/acetate kinase; Provisional; Region: PRK12379 1194526003062 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1194526003063 nucleotide binding site [chemical binding]; other site 1194526003064 butyrate kinase; Provisional; Region: PRK03011 1194526003065 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1194526003066 Ligand Binding Site [chemical binding]; other site 1194526003067 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1194526003068 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1194526003069 hexamer interface [polypeptide binding]; other site 1194526003070 ligand binding site [chemical binding]; other site 1194526003071 putative active site [active] 1194526003072 NAD(P) binding site [chemical binding]; other site 1194526003073 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1194526003074 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1194526003075 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1194526003076 active site 1194526003077 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1194526003078 metal-dependent hydrolase; Provisional; Region: PRK00685 1194526003079 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1194526003080 Ligand Binding Site [chemical binding]; other site 1194526003081 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1194526003082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1194526003083 DNA-binding site [nucleotide binding]; DNA binding site 1194526003084 DRTGG domain; Region: DRTGG; pfam07085 1194526003085 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1194526003086 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1194526003087 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1194526003088 DHH family; Region: DHH; pfam01368 1194526003089 DHHA1 domain; Region: DHHA1; pfam02272 1194526003090 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1194526003091 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1194526003092 active site 1194526003093 PHP Thumb interface [polypeptide binding]; other site 1194526003094 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1194526003095 generic binding surface I; other site 1194526003096 generic binding surface II; other site 1194526003097 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1194526003098 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1194526003099 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1194526003100 putative NAD(P) binding site [chemical binding]; other site 1194526003101 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1194526003102 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1194526003103 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1194526003104 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1194526003105 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1194526003106 6-phosphofructokinase; Provisional; Region: PRK03202 1194526003107 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1194526003108 active site 1194526003109 ADP/pyrophosphate binding site [chemical binding]; other site 1194526003110 dimerization interface [polypeptide binding]; other site 1194526003111 allosteric effector site; other site 1194526003112 fructose-1,6-bisphosphate binding site; other site 1194526003113 pyruvate kinase; Provisional; Region: PRK06354 1194526003114 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1194526003115 domain interfaces; other site 1194526003116 active site 1194526003117 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1194526003118 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1194526003119 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1194526003120 dimer interface [polypeptide binding]; other site 1194526003121 Citrate synthase; Region: Citrate_synt; pfam00285 1194526003122 active site 1194526003123 citrylCoA binding site [chemical binding]; other site 1194526003124 oxalacetate/citrate binding site [chemical binding]; other site 1194526003125 coenzyme A binding site [chemical binding]; other site 1194526003126 catalytic triad [active] 1194526003127 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1194526003128 isocitrate dehydrogenase; Validated; Region: PRK07362 1194526003129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1194526003130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526003131 active site 1194526003132 phosphorylation site [posttranslational modification] 1194526003133 intermolecular recognition site; other site 1194526003134 dimerization interface [polypeptide binding]; other site 1194526003135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1194526003136 DNA binding site [nucleotide binding] 1194526003137 HAMP domain; Region: HAMP; pfam00672 1194526003138 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1194526003139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1194526003140 dimer interface [polypeptide binding]; other site 1194526003141 phosphorylation site [posttranslational modification] 1194526003142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526003143 ATP binding site [chemical binding]; other site 1194526003144 Mg2+ binding site [ion binding]; other site 1194526003145 G-X-G motif; other site 1194526003146 DNA polymerase I; Provisional; Region: PRK05755 1194526003147 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1194526003148 active site 1194526003149 metal binding site 1 [ion binding]; metal-binding site 1194526003150 putative 5' ssDNA interaction site; other site 1194526003151 metal binding site 3; metal-binding site 1194526003152 metal binding site 2 [ion binding]; metal-binding site 1194526003153 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1194526003154 putative DNA binding site [nucleotide binding]; other site 1194526003155 putative metal binding site [ion binding]; other site 1194526003156 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1194526003157 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1194526003158 active site 1194526003159 DNA binding site [nucleotide binding] 1194526003160 catalytic site [active] 1194526003161 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1194526003162 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1194526003163 DNA binding site [nucleotide binding] 1194526003164 catalytic residue [active] 1194526003165 H2TH interface [polypeptide binding]; other site 1194526003166 putative catalytic residues [active] 1194526003167 turnover-facilitating residue; other site 1194526003168 intercalation triad [nucleotide binding]; other site 1194526003169 8OG recognition residue [nucleotide binding]; other site 1194526003170 putative reading head residues; other site 1194526003171 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1194526003172 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1194526003173 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1194526003174 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1194526003175 CoA-binding site [chemical binding]; other site 1194526003176 ATP-binding [chemical binding]; other site 1194526003177 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1194526003178 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1194526003179 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1194526003180 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1194526003181 ATP cone domain; Region: ATP-cone; pfam03477 1194526003182 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1194526003183 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1194526003184 primosomal protein DnaI; Reviewed; Region: PRK08939 1194526003185 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1194526003186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526003187 Walker A motif; other site 1194526003188 ATP binding site [chemical binding]; other site 1194526003189 Walker B motif; other site 1194526003190 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1194526003191 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1194526003192 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1194526003193 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1194526003194 active site 1194526003195 dimer interface [polypeptide binding]; other site 1194526003196 motif 1; other site 1194526003197 motif 2; other site 1194526003198 motif 3; other site 1194526003199 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1194526003200 anticodon binding site; other site 1194526003201 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1194526003202 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1194526003203 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1194526003204 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1194526003205 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1194526003206 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1194526003207 23S rRNA binding site [nucleotide binding]; other site 1194526003208 L21 binding site [polypeptide binding]; other site 1194526003209 L13 binding site [polypeptide binding]; other site 1194526003210 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1194526003211 trigger factor; Provisional; Region: tig; PRK01490 1194526003212 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1194526003213 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1194526003214 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1194526003215 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1194526003216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526003217 Walker A motif; other site 1194526003218 ATP binding site [chemical binding]; other site 1194526003219 Walker B motif; other site 1194526003220 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1194526003221 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1194526003222 G1 box; other site 1194526003223 GTP/Mg2+ binding site [chemical binding]; other site 1194526003224 Switch I region; other site 1194526003225 G2 box; other site 1194526003226 G3 box; other site 1194526003227 Switch II region; other site 1194526003228 G4 box; other site 1194526003229 G5 box; other site 1194526003230 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1194526003231 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1194526003232 tRNA; other site 1194526003233 putative tRNA binding site [nucleotide binding]; other site 1194526003234 putative NADP binding site [chemical binding]; other site 1194526003235 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1194526003236 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1194526003237 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1194526003238 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1194526003239 domain interfaces; other site 1194526003240 active site 1194526003241 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1194526003242 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1194526003243 active site 1194526003244 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1194526003245 dimer interface [polypeptide binding]; other site 1194526003246 active site 1194526003247 Schiff base residues; other site 1194526003248 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1194526003249 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1194526003250 inhibitor-cofactor binding pocket; inhibition site 1194526003251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526003252 catalytic residue [active] 1194526003253 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1194526003254 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1194526003255 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1194526003256 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1194526003257 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1194526003258 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1194526003259 active site 1194526003260 HIGH motif; other site 1194526003261 nucleotide binding site [chemical binding]; other site 1194526003262 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1194526003263 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1194526003264 active site 1194526003265 KMSKS motif; other site 1194526003266 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1194526003267 tRNA binding surface [nucleotide binding]; other site 1194526003268 anticodon binding site; other site 1194526003269 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1194526003270 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1194526003271 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1194526003272 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1194526003273 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1194526003274 hypothetical protein; Reviewed; Region: PRK00024 1194526003275 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1194526003276 MPN+ (JAMM) motif; other site 1194526003277 Zinc-binding site [ion binding]; other site 1194526003278 rod shape-determining protein MreC; Provisional; Region: PRK13922 1194526003279 rod shape-determining protein MreC; Region: MreC; pfam04085 1194526003280 rod shape-determining protein MreD; Region: MreD; cl01087 1194526003281 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1194526003282 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1194526003283 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1194526003284 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1194526003285 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1194526003286 GTP1/OBG; Region: GTP1_OBG; pfam01018 1194526003287 Obg GTPase; Region: Obg; cd01898 1194526003288 G1 box; other site 1194526003289 GTP/Mg2+ binding site [chemical binding]; other site 1194526003290 Switch I region; other site 1194526003291 G2 box; other site 1194526003292 G3 box; other site 1194526003293 Switch II region; other site 1194526003294 G4 box; other site 1194526003295 G5 box; other site 1194526003296 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1194526003297 hypothetical protein; Provisional; Region: PRK04435 1194526003298 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1194526003299 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1194526003300 RuvA N terminal domain; Region: RuvA_N; pfam01330 1194526003301 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1194526003302 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1194526003303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526003304 Walker A motif; other site 1194526003305 ATP binding site [chemical binding]; other site 1194526003306 Walker B motif; other site 1194526003307 arginine finger; other site 1194526003308 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1194526003309 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1194526003310 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1194526003311 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1194526003312 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1194526003313 Preprotein translocase subunit; Region: YajC; pfam02699 1194526003314 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1194526003315 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1194526003316 Protein export membrane protein; Region: SecD_SecF; cl14618 1194526003317 Protein export membrane protein; Region: SecD_SecF; pfam02355 1194526003318 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1194526003319 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1194526003320 DHH family; Region: DHH; pfam01368 1194526003321 DHHA1 domain; Region: DHHA1; pfam02272 1194526003322 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1194526003323 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526003324 active site 1194526003325 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1194526003326 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1194526003327 Zn2+ binding site [ion binding]; other site 1194526003328 Mg2+ binding site [ion binding]; other site 1194526003329 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1194526003330 synthetase active site [active] 1194526003331 NTP binding site [chemical binding]; other site 1194526003332 metal binding site [ion binding]; metal-binding site 1194526003333 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1194526003334 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1194526003335 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1194526003336 putative active site [active] 1194526003337 dimerization interface [polypeptide binding]; other site 1194526003338 putative tRNAtyr binding site [nucleotide binding]; other site 1194526003339 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1194526003340 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1194526003341 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1194526003342 active site 1194526003343 metal binding site [ion binding]; metal-binding site 1194526003344 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1194526003345 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1194526003346 dimer interface [polypeptide binding]; other site 1194526003347 motif 1; other site 1194526003348 active site 1194526003349 motif 2; other site 1194526003350 motif 3; other site 1194526003351 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1194526003352 anticodon binding site; other site 1194526003353 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1194526003354 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1194526003355 dimer interface [polypeptide binding]; other site 1194526003356 anticodon binding site; other site 1194526003357 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1194526003358 homodimer interface [polypeptide binding]; other site 1194526003359 motif 1; other site 1194526003360 active site 1194526003361 motif 2; other site 1194526003362 GAD domain; Region: GAD; pfam02938 1194526003363 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1194526003364 motif 3; other site 1194526003365 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1194526003366 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1194526003367 putative ATP binding site [chemical binding]; other site 1194526003368 putative substrate interface [chemical binding]; other site 1194526003369 recombination factor protein RarA; Reviewed; Region: PRK13342 1194526003370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526003371 Walker A motif; other site 1194526003372 ATP binding site [chemical binding]; other site 1194526003373 Walker B motif; other site 1194526003374 arginine finger; other site 1194526003375 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1194526003376 Predicted transcriptional regulator [Transcription]; Region: COG1959 1194526003377 Transcriptional regulator; Region: Rrf2; pfam02082 1194526003378 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1194526003379 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1194526003380 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1194526003381 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1194526003382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1194526003383 catalytic residue [active] 1194526003384 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1194526003385 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1194526003386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1194526003387 binding surface 1194526003388 TPR repeat; Region: TPR_11; pfam13414 1194526003389 TPR motif; other site 1194526003390 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1194526003391 TPR repeat; Region: TPR_11; pfam13414 1194526003392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1194526003393 binding surface 1194526003394 TPR motif; other site 1194526003395 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1194526003396 AAA domain; Region: AAA_30; pfam13604 1194526003397 Family description; Region: UvrD_C_2; pfam13538 1194526003398 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1194526003399 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1194526003400 motif 1; other site 1194526003401 active site 1194526003402 motif 2; other site 1194526003403 motif 3; other site 1194526003404 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1194526003405 DHHA1 domain; Region: DHHA1; pfam02272 1194526003406 hypothetical protein; Provisional; Region: PRK05473 1194526003407 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1194526003408 hypothetical protein; Provisional; Region: PRK13678 1194526003409 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1194526003410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526003411 S-adenosylmethionine binding site [chemical binding]; other site 1194526003412 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1194526003413 Peptidase family U32; Region: Peptidase_U32; pfam01136 1194526003414 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1194526003415 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1194526003416 Peptidase family U32; Region: Peptidase_U32; pfam01136 1194526003417 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1194526003418 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1194526003419 Sugar specificity; other site 1194526003420 Pyrimidine base specificity; other site 1194526003421 ATP-binding site [chemical binding]; other site 1194526003422 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1194526003423 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1194526003424 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1194526003425 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1194526003426 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1194526003427 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1194526003428 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1194526003429 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1194526003430 carboxyltransferase (CT) interaction site; other site 1194526003431 biotinylation site [posttranslational modification]; other site 1194526003432 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1194526003433 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1194526003434 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1194526003435 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1194526003436 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1194526003437 putative active site [active] 1194526003438 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1194526003439 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1194526003440 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1194526003441 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1194526003442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526003443 active site 1194526003444 motif I; other site 1194526003445 motif II; other site 1194526003446 GTPase YqeH; Provisional; Region: PRK13796 1194526003447 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1194526003448 GTP/Mg2+ binding site [chemical binding]; other site 1194526003449 G4 box; other site 1194526003450 G5 box; other site 1194526003451 G1 box; other site 1194526003452 Switch I region; other site 1194526003453 G2 box; other site 1194526003454 G3 box; other site 1194526003455 Switch II region; other site 1194526003456 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1194526003457 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1194526003458 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1194526003459 shikimate binding site; other site 1194526003460 NAD(P) binding site [chemical binding]; other site 1194526003461 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1194526003462 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1194526003463 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1194526003464 active site 1194526003465 (T/H)XGH motif; other site 1194526003466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1194526003467 Zn2+ binding site [ion binding]; other site 1194526003468 Mg2+ binding site [ion binding]; other site 1194526003469 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1194526003470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526003471 S-adenosylmethionine binding site [chemical binding]; other site 1194526003472 SLBB domain; Region: SLBB; pfam10531 1194526003473 comEA protein; Region: comE; TIGR01259 1194526003474 Helix-hairpin-helix motif; Region: HHH; pfam00633 1194526003475 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1194526003476 catalytic motif [active] 1194526003477 Zn binding site [ion binding]; other site 1194526003478 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1194526003479 Competence protein; Region: Competence; pfam03772 1194526003480 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1194526003481 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1194526003482 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1194526003483 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1194526003484 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1194526003485 GTP-binding protein LepA; Provisional; Region: PRK05433 1194526003486 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1194526003487 G1 box; other site 1194526003488 putative GEF interaction site [polypeptide binding]; other site 1194526003489 GTP/Mg2+ binding site [chemical binding]; other site 1194526003490 Switch I region; other site 1194526003491 G2 box; other site 1194526003492 G3 box; other site 1194526003493 Switch II region; other site 1194526003494 G4 box; other site 1194526003495 G5 box; other site 1194526003496 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1194526003497 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1194526003498 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1194526003499 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1194526003500 HemN C-terminal domain; Region: HemN_C; pfam06969 1194526003501 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1194526003502 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1194526003503 heat shock protein GrpE; Provisional; Region: PRK14140 1194526003504 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1194526003505 dimer interface [polypeptide binding]; other site 1194526003506 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1194526003507 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1194526003508 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1194526003509 nucleotide binding site [chemical binding]; other site 1194526003510 NEF interaction site [polypeptide binding]; other site 1194526003511 SBD interface [polypeptide binding]; other site 1194526003512 chaperone protein DnaJ; Provisional; Region: PRK14280 1194526003513 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1194526003514 HSP70 interaction site [polypeptide binding]; other site 1194526003515 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1194526003516 substrate binding site [polypeptide binding]; other site 1194526003517 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1194526003518 Zn binding sites [ion binding]; other site 1194526003519 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1194526003520 dimer interface [polypeptide binding]; other site 1194526003521 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1194526003522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526003523 S-adenosylmethionine binding site [chemical binding]; other site 1194526003524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1194526003525 RNA methyltransferase, RsmE family; Region: TIGR00046 1194526003526 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1194526003527 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1194526003528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1194526003529 FeS/SAM binding site; other site 1194526003530 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1194526003531 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1194526003532 hypothetical protein; Provisional; Region: PRK13665 1194526003533 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1194526003534 PhoH-like protein; Region: PhoH; pfam02562 1194526003535 metal-binding heat shock protein; Provisional; Region: PRK00016 1194526003536 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1194526003537 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1194526003538 active site 1194526003539 catalytic motif [active] 1194526003540 Zn binding site [ion binding]; other site 1194526003541 GTPase Era; Reviewed; Region: era; PRK00089 1194526003542 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1194526003543 G1 box; other site 1194526003544 GTP/Mg2+ binding site [chemical binding]; other site 1194526003545 Switch I region; other site 1194526003546 G2 box; other site 1194526003547 Switch II region; other site 1194526003548 G3 box; other site 1194526003549 G4 box; other site 1194526003550 G5 box; other site 1194526003551 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1194526003552 DNA repair protein RecO; Region: reco; TIGR00613 1194526003553 Recombination protein O N terminal; Region: RecO_N; pfam11967 1194526003554 Recombination protein O C terminal; Region: RecO_C; pfam02565 1194526003555 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1194526003556 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1194526003557 motif 1; other site 1194526003558 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1194526003559 active site 1194526003560 motif 2; other site 1194526003561 motif 3; other site 1194526003562 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1194526003563 anticodon binding site; other site 1194526003564 FOG: CBS domain [General function prediction only]; Region: COG0517 1194526003565 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1194526003566 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1194526003567 DNA primase, catalytic core; Region: dnaG; TIGR01391 1194526003568 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1194526003569 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1194526003570 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1194526003571 active site 1194526003572 metal binding site [ion binding]; metal-binding site 1194526003573 interdomain interaction site; other site 1194526003574 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1194526003575 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1194526003576 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1194526003577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1194526003578 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1194526003579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1194526003580 DNA binding residues [nucleotide binding] 1194526003581 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1194526003582 Family of unknown function (DUF633); Region: DUF633; pfam04816 1194526003583 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1194526003584 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1194526003585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1194526003586 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1194526003587 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1194526003588 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1194526003589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1194526003590 ATP binding site [chemical binding]; other site 1194526003591 putative Mg++ binding site [ion binding]; other site 1194526003592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526003593 nucleotide binding region [chemical binding]; other site 1194526003594 ATP-binding site [chemical binding]; other site 1194526003595 endonuclease IV; Provisional; Region: PRK01060 1194526003596 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1194526003597 AP (apurinic/apyrimidinic) site pocket; other site 1194526003598 DNA interaction; other site 1194526003599 Metal-binding active site; metal-binding site 1194526003600 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1194526003601 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1194526003602 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1194526003603 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1194526003604 ABC-ATPase subunit interface; other site 1194526003605 dimer interface [polypeptide binding]; other site 1194526003606 putative PBP binding regions; other site 1194526003607 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1194526003608 metal binding site 2 [ion binding]; metal-binding site 1194526003609 putative DNA binding helix; other site 1194526003610 metal binding site 1 [ion binding]; metal-binding site 1194526003611 dimer interface [polypeptide binding]; other site 1194526003612 structural Zn2+ binding site [ion binding]; other site 1194526003613 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1194526003614 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1194526003615 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1194526003616 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1194526003617 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1194526003618 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1194526003619 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1194526003620 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1194526003621 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1194526003622 Rhomboid family; Region: Rhomboid; pfam01694 1194526003623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1194526003624 binding surface 1194526003625 TPR motif; other site 1194526003626 TPR repeat; Region: TPR_11; pfam13414 1194526003627 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1194526003628 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1194526003629 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1194526003630 nucleotide binding site [chemical binding]; other site 1194526003631 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1194526003632 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1194526003633 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1194526003634 Type II/IV secretion system protein; Region: T2SE; pfam00437 1194526003635 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1194526003636 Walker A motif; other site 1194526003637 ATP binding site [chemical binding]; other site 1194526003638 Walker B motif; other site 1194526003639 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1194526003640 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1194526003641 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1194526003642 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1194526003643 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1194526003644 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1194526003645 ADP binding site [chemical binding]; other site 1194526003646 magnesium binding site [ion binding]; other site 1194526003647 putative shikimate binding site; other site 1194526003648 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1194526003649 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1194526003650 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1194526003651 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1194526003652 tetramer interface [polypeptide binding]; other site 1194526003653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526003654 catalytic residue [active] 1194526003655 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1194526003656 tetramer interface [polypeptide binding]; other site 1194526003657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526003658 catalytic residue [active] 1194526003659 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1194526003660 active site residue [active] 1194526003661 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1194526003662 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1194526003663 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1194526003664 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1194526003665 active site 1194526003666 elongation factor P; Validated; Region: PRK00529 1194526003667 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1194526003668 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1194526003669 RNA binding site [nucleotide binding]; other site 1194526003670 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1194526003671 RNA binding site [nucleotide binding]; other site 1194526003672 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1194526003673 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1194526003674 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1194526003675 heterotetramer interface [polypeptide binding]; other site 1194526003676 active site pocket [active] 1194526003677 cleavage site 1194526003678 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1194526003679 nucleotide binding site [chemical binding]; other site 1194526003680 N-acetyl-L-glutamate binding site [chemical binding]; other site 1194526003681 acetylornithine aminotransferase; Provisional; Region: PRK04260 1194526003682 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1194526003683 inhibitor-cofactor binding pocket; inhibition site 1194526003684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526003685 catalytic residue [active] 1194526003686 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1194526003687 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1194526003688 carboxyltransferase (CT) interaction site; other site 1194526003689 biotinylation site [posttranslational modification]; other site 1194526003690 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1194526003691 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1194526003692 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1194526003693 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1194526003694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1194526003695 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1194526003696 putative RNA binding site [nucleotide binding]; other site 1194526003697 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1194526003698 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1194526003699 generic binding surface II; other site 1194526003700 generic binding surface I; other site 1194526003701 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1194526003702 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1194526003703 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1194526003704 substrate binding pocket [chemical binding]; other site 1194526003705 chain length determination region; other site 1194526003706 substrate-Mg2+ binding site; other site 1194526003707 catalytic residues [active] 1194526003708 aspartate-rich region 1; other site 1194526003709 active site lid residues [active] 1194526003710 aspartate-rich region 2; other site 1194526003711 arginine repressor; Provisional; Region: PRK04280 1194526003712 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1194526003713 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1194526003714 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1194526003715 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1194526003716 Walker A/P-loop; other site 1194526003717 ATP binding site [chemical binding]; other site 1194526003718 Q-loop/lid; other site 1194526003719 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1194526003720 Q-loop/lid; other site 1194526003721 ABC transporter signature motif; other site 1194526003722 Walker B; other site 1194526003723 D-loop; other site 1194526003724 H-loop/switch region; other site 1194526003725 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1194526003726 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1194526003727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526003728 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1194526003729 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1194526003730 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1194526003731 tetramer interface [polypeptide binding]; other site 1194526003732 TPP-binding site [chemical binding]; other site 1194526003733 heterodimer interface [polypeptide binding]; other site 1194526003734 phosphorylation loop region [posttranslational modification] 1194526003735 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1194526003736 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1194526003737 alpha subunit interface [polypeptide binding]; other site 1194526003738 TPP binding site [chemical binding]; other site 1194526003739 heterodimer interface [polypeptide binding]; other site 1194526003740 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1194526003741 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1194526003742 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1194526003743 E3 interaction surface; other site 1194526003744 lipoyl attachment site [posttranslational modification]; other site 1194526003745 e3 binding domain; Region: E3_binding; pfam02817 1194526003746 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1194526003747 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1194526003748 Predicted membrane protein [Function unknown]; Region: COG4129 1194526003749 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1194526003750 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1194526003751 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1194526003752 peptidase T-like protein; Region: PepT-like; TIGR01883 1194526003753 metal binding site [ion binding]; metal-binding site 1194526003754 putative dimer interface [polypeptide binding]; other site 1194526003755 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1194526003756 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1194526003757 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1194526003758 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1194526003759 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1194526003760 Ca binding site [ion binding]; other site 1194526003761 active site 1194526003762 catalytic site [active] 1194526003763 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1194526003764 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1194526003765 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1194526003766 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1194526003767 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1194526003768 ribonuclease Z; Region: RNase_Z; TIGR02651 1194526003769 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1194526003770 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1194526003771 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1194526003772 classical (c) SDRs; Region: SDR_c; cd05233 1194526003773 NAD(P) binding site [chemical binding]; other site 1194526003774 active site 1194526003775 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1194526003776 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1194526003777 active site 1194526003778 catalytic tetrad [active] 1194526003779 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1194526003780 dimer interface [polypeptide binding]; other site 1194526003781 ADP-ribose binding site [chemical binding]; other site 1194526003782 active site 1194526003783 nudix motif; other site 1194526003784 metal binding site [ion binding]; metal-binding site 1194526003785 ferric uptake regulator; Provisional; Region: fur; PRK09462 1194526003786 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1194526003787 metal binding site 2 [ion binding]; metal-binding site 1194526003788 putative DNA binding helix; other site 1194526003789 metal binding site 1 [ion binding]; metal-binding site 1194526003790 dimer interface [polypeptide binding]; other site 1194526003791 structural Zn2+ binding site [ion binding]; other site 1194526003792 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1194526003793 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1194526003794 active site 1194526003795 Int/Topo IB signature motif; other site 1194526003796 Domain of unknown function (DUF309); Region: DUF309; cl00667 1194526003797 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1194526003798 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1194526003799 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1194526003800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1194526003801 RNA binding surface [nucleotide binding]; other site 1194526003802 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1194526003803 active site 1194526003804 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1194526003805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526003806 active site 1194526003807 phosphorylation site [posttranslational modification] 1194526003808 intermolecular recognition site; other site 1194526003809 dimerization interface [polypeptide binding]; other site 1194526003810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1194526003811 DNA binding site [nucleotide binding] 1194526003812 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1194526003813 dimerization interface [polypeptide binding]; other site 1194526003814 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1194526003815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1194526003816 dimer interface [polypeptide binding]; other site 1194526003817 phosphorylation site [posttranslational modification] 1194526003818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526003819 ATP binding site [chemical binding]; other site 1194526003820 Mg2+ binding site [ion binding]; other site 1194526003821 G-X-G motif; other site 1194526003822 Predicted membrane protein [Function unknown]; Region: COG3601 1194526003823 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1194526003824 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1194526003825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1194526003826 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1194526003827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1194526003828 ATP binding site [chemical binding]; other site 1194526003829 putative Mg++ binding site [ion binding]; other site 1194526003830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526003831 nucleotide binding region [chemical binding]; other site 1194526003832 ATP-binding site [chemical binding]; other site 1194526003833 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1194526003834 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1194526003835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1194526003836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526003837 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1194526003838 active site 1194526003839 homotetramer interface [polypeptide binding]; other site 1194526003840 homodimer interface [polypeptide binding]; other site 1194526003841 cytidylate kinase; Provisional; Region: cmk; PRK00023 1194526003842 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1194526003843 CMP-binding site; other site 1194526003844 The sites determining sugar specificity; other site 1194526003845 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1194526003846 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1194526003847 RNA binding site [nucleotide binding]; other site 1194526003848 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1194526003849 RNA binding site [nucleotide binding]; other site 1194526003850 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1194526003851 RNA binding site [nucleotide binding]; other site 1194526003852 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1194526003853 RNA binding site [nucleotide binding]; other site 1194526003854 GTP-binding protein Der; Reviewed; Region: PRK00093 1194526003855 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1194526003856 G1 box; other site 1194526003857 GTP/Mg2+ binding site [chemical binding]; other site 1194526003858 Switch I region; other site 1194526003859 G2 box; other site 1194526003860 Switch II region; other site 1194526003861 G3 box; other site 1194526003862 G4 box; other site 1194526003863 G5 box; other site 1194526003864 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1194526003865 G1 box; other site 1194526003866 GTP/Mg2+ binding site [chemical binding]; other site 1194526003867 Switch I region; other site 1194526003868 G2 box; other site 1194526003869 G3 box; other site 1194526003870 Switch II region; other site 1194526003871 G4 box; other site 1194526003872 G5 box; other site 1194526003873 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1194526003874 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1194526003875 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1194526003876 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1194526003877 IHF dimer interface [polypeptide binding]; other site 1194526003878 IHF - DNA interface [nucleotide binding]; other site 1194526003879 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1194526003880 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1194526003881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526003882 S-adenosylmethionine binding site [chemical binding]; other site 1194526003883 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1194526003884 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1194526003885 substrate binding pocket [chemical binding]; other site 1194526003886 chain length determination region; other site 1194526003887 substrate-Mg2+ binding site; other site 1194526003888 catalytic residues [active] 1194526003889 aspartate-rich region 1; other site 1194526003890 active site lid residues [active] 1194526003891 aspartate-rich region 2; other site 1194526003892 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1194526003893 active site 1194526003894 multimer interface [polypeptide binding]; other site 1194526003895 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1194526003896 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1194526003897 Tetramer interface [polypeptide binding]; other site 1194526003898 active site 1194526003899 FMN-binding site [chemical binding]; other site 1194526003900 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1194526003901 active site 1194526003902 dimer interface [polypeptide binding]; other site 1194526003903 metal binding site [ion binding]; metal-binding site 1194526003904 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1194526003905 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1194526003906 hinge; other site 1194526003907 active site 1194526003908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1194526003909 binding surface 1194526003910 TPR motif; other site 1194526003911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1194526003912 TPR motif; other site 1194526003913 binding surface 1194526003914 UPF0302 domain; Region: UPF0302; pfam08864 1194526003915 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1194526003916 IDEAL domain; Region: IDEAL; pfam08858 1194526003917 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1194526003918 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1194526003919 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1194526003920 homodimer interface [polypeptide binding]; other site 1194526003921 metal binding site [ion binding]; metal-binding site 1194526003922 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1194526003923 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1194526003924 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1194526003925 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1194526003926 active site 1194526003927 NTP binding site [chemical binding]; other site 1194526003928 metal binding triad [ion binding]; metal-binding site 1194526003929 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1194526003930 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1194526003931 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1194526003932 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1194526003933 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1194526003934 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1194526003935 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1194526003936 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1194526003937 active site 1194526003938 catalytic site [active] 1194526003939 substrate binding site [chemical binding]; other site 1194526003940 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1194526003941 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1194526003942 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1194526003943 putative dimer interface [polypeptide binding]; other site 1194526003944 putative anticodon binding site; other site 1194526003945 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1194526003946 homodimer interface [polypeptide binding]; other site 1194526003947 motif 1; other site 1194526003948 motif 2; other site 1194526003949 active site 1194526003950 motif 3; other site 1194526003951 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1194526003952 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1194526003953 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1194526003954 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1194526003955 minor groove reading motif; other site 1194526003956 helix-hairpin-helix signature motif; other site 1194526003957 substrate binding pocket [chemical binding]; other site 1194526003958 active site 1194526003959 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1194526003960 Transglycosylase; Region: Transgly; pfam00912 1194526003961 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1194526003962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1194526003963 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1194526003964 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1194526003965 hypothetical protein; Provisional; Region: PRK13660 1194526003966 cell division protein GpsB; Provisional; Region: PRK14127 1194526003967 DivIVA domain; Region: DivI1A_domain; TIGR03544 1194526003968 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1194526003969 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1194526003970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1194526003971 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1194526003972 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1194526003973 putative NAD(P) binding site [chemical binding]; other site 1194526003974 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1194526003975 Dynamin family; Region: Dynamin_N; pfam00350 1194526003976 G1 box; other site 1194526003977 GTP/Mg2+ binding site [chemical binding]; other site 1194526003978 G2 box; other site 1194526003979 Switch I region; other site 1194526003980 G3 box; other site 1194526003981 Switch II region; other site 1194526003982 G4 box; other site 1194526003983 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1194526003984 Dynamin family; Region: Dynamin_N; pfam00350 1194526003985 G1 box; other site 1194526003986 GTP/Mg2+ binding site [chemical binding]; other site 1194526003987 G2 box; other site 1194526003988 Switch I region; other site 1194526003989 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1194526003990 G3 box; other site 1194526003991 Switch II region; other site 1194526003992 GTP/Mg2+ binding site [chemical binding]; other site 1194526003993 G4 box; other site 1194526003994 G5 box; other site 1194526003995 5'-3' exonuclease; Region: 53EXOc; smart00475 1194526003996 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1194526003997 active site 1194526003998 metal binding site 1 [ion binding]; metal-binding site 1194526003999 putative 5' ssDNA interaction site; other site 1194526004000 metal binding site 3; metal-binding site 1194526004001 metal binding site 2 [ion binding]; metal-binding site 1194526004002 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1194526004003 putative DNA binding site [nucleotide binding]; other site 1194526004004 putative metal binding site [ion binding]; other site 1194526004005 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1194526004006 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1194526004007 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1194526004008 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1194526004009 GA module; Region: GA; smart00844 1194526004010 GA module; Region: GA; smart00844 1194526004011 GA module; Region: GA; smart00844 1194526004012 GA module; Region: GA; smart00844 1194526004013 GA module; Region: GA; smart00844 1194526004014 GA module; Region: GA; smart00844 1194526004015 GA module; Region: GA; pfam01468 1194526004016 Predicted membrane protein [Function unknown]; Region: COG1511 1194526004017 GA module; Region: GA; smart00844 1194526004018 GA module; Region: GA; smart00844 1194526004019 GA module; Region: GA; smart00844 1194526004020 GA module; Region: GA; smart00844 1194526004021 GA module; Region: GA; smart00844 1194526004022 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1194526004023 GA module; Region: GA; smart00844 1194526004024 GA module; Region: GA; smart00844 1194526004025 GA module; Region: GA; smart00844 1194526004026 GA module; Region: GA; smart00844 1194526004027 GA module; Region: GA; smart00844 1194526004028 GA module; Region: GA; smart00844 1194526004029 GA module; Region: GA; smart00844 1194526004030 GA module; Region: GA; smart00844 1194526004031 GA module; Region: GA; smart00844 1194526004032 GA module; Region: GA; smart00844 1194526004033 GA module; Region: GA; smart00844 1194526004034 GA module; Region: GA; smart00844 1194526004035 GA module; Region: GA; smart00844 1194526004036 GA module; Region: GA; smart00844 1194526004037 GA module; Region: GA; smart00844 1194526004038 GA module; Region: GA; smart00844 1194526004039 GA module; Region: GA; smart00844 1194526004040 GA module; Region: GA; smart00844 1194526004041 GA module; Region: GA; smart00844 1194526004042 GA module; Region: GA; smart00844 1194526004043 GA module; Region: GA; smart00844 1194526004044 GA module; Region: GA; smart00844 1194526004045 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526004046 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526004047 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526004048 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526004049 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1194526004050 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1194526004051 RNA/DNA hybrid binding site [nucleotide binding]; other site 1194526004052 active site 1194526004053 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1194526004054 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1194526004055 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1194526004056 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1194526004057 Virulence factor; Region: Virulence_fact; pfam13769 1194526004058 HEAT repeats; Region: HEAT_2; pfam13646 1194526004059 HEAT repeat; Region: HEAT; pfam02985 1194526004060 Disulphide isomerase; Region: Disulph_isomer; cl05813 1194526004061 thymidylate synthase; Region: thym_sym; TIGR03284 1194526004062 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1194526004063 dimerization interface [polypeptide binding]; other site 1194526004064 active site 1194526004065 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1194526004066 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1194526004067 folate binding site [chemical binding]; other site 1194526004068 NADP+ binding site [chemical binding]; other site 1194526004069 EDD domain protein, DegV family; Region: DegV; TIGR00762 1194526004070 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1194526004071 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1194526004072 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1194526004073 SelR domain; Region: SelR; pfam01641 1194526004074 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1194526004075 HPr interaction site; other site 1194526004076 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1194526004077 active site 1194526004078 phosphorylation site [posttranslational modification] 1194526004079 hypothetical protein; Provisional; Region: PRK13672 1194526004080 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1194526004081 C-terminal peptidase (prc); Region: prc; TIGR00225 1194526004082 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1194526004083 protein binding site [polypeptide binding]; other site 1194526004084 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1194526004085 Catalytic dyad [active] 1194526004086 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1194526004087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1194526004088 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1194526004089 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1194526004090 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1194526004091 active site 1194526004092 homodimer interface [polypeptide binding]; other site 1194526004093 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1194526004094 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1194526004095 active site 1194526004096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1194526004097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526004098 active site 1194526004099 phosphorylation site [posttranslational modification] 1194526004100 intermolecular recognition site; other site 1194526004101 dimerization interface [polypeptide binding]; other site 1194526004102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1194526004103 DNA binding site [nucleotide binding] 1194526004104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1194526004105 HAMP domain; Region: HAMP; pfam00672 1194526004106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1194526004107 dimer interface [polypeptide binding]; other site 1194526004108 phosphorylation site [posttranslational modification] 1194526004109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526004110 ATP binding site [chemical binding]; other site 1194526004111 Mg2+ binding site [ion binding]; other site 1194526004112 G-X-G motif; other site 1194526004113 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1194526004114 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1194526004115 TPP-binding site [chemical binding]; other site 1194526004116 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1194526004117 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1194526004118 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1194526004119 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1194526004120 E3 interaction surface; other site 1194526004121 lipoyl attachment site [posttranslational modification]; other site 1194526004122 e3 binding domain; Region: E3_binding; pfam02817 1194526004123 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1194526004124 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1194526004125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526004126 Walker A/P-loop; other site 1194526004127 ATP binding site [chemical binding]; other site 1194526004128 Q-loop/lid; other site 1194526004129 ABC transporter signature motif; other site 1194526004130 Walker B; other site 1194526004131 D-loop; other site 1194526004132 H-loop/switch region; other site 1194526004133 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1194526004134 active site 1194526004135 MoxR-like ATPases [General function prediction only]; Region: COG0714 1194526004136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526004137 Walker A motif; other site 1194526004138 ATP binding site [chemical binding]; other site 1194526004139 Walker B motif; other site 1194526004140 arginine finger; other site 1194526004141 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1194526004142 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1194526004143 metal ion-dependent adhesion site (MIDAS); other site 1194526004144 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1194526004145 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1194526004146 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1194526004147 acylphosphatase; Provisional; Region: PRK14431 1194526004148 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1194526004149 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1194526004150 DNA-binding site [nucleotide binding]; DNA binding site 1194526004151 RNA-binding motif; other site 1194526004152 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1194526004153 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1194526004154 active site 1194526004155 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1194526004156 substrate binding site [chemical binding]; other site 1194526004157 catalytic residues [active] 1194526004158 dimer interface [polypeptide binding]; other site 1194526004159 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1194526004160 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1194526004161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1194526004162 catalytic residue [active] 1194526004163 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1194526004164 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1194526004165 metal binding site [ion binding]; metal-binding site 1194526004166 dimer interface [polypeptide binding]; other site 1194526004167 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1194526004168 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1194526004169 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1194526004170 trimer interface [polypeptide binding]; other site 1194526004171 active site 1194526004172 substrate binding site [chemical binding]; other site 1194526004173 CoA binding site [chemical binding]; other site 1194526004174 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1194526004175 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1194526004176 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1194526004177 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1194526004178 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1194526004179 dimer interface [polypeptide binding]; other site 1194526004180 active site 1194526004181 catalytic residue [active] 1194526004182 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1194526004183 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1194526004184 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1194526004185 aspartate kinase; Reviewed; Region: PRK06635 1194526004186 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1194526004187 putative nucleotide binding site [chemical binding]; other site 1194526004188 putative catalytic residues [active] 1194526004189 putative Mg ion binding site [ion binding]; other site 1194526004190 putative aspartate binding site [chemical binding]; other site 1194526004191 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1194526004192 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1194526004193 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1194526004194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526004195 Walker A/P-loop; other site 1194526004196 ATP binding site [chemical binding]; other site 1194526004197 Q-loop/lid; other site 1194526004198 ABC transporter signature motif; other site 1194526004199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1194526004200 Walker B; other site 1194526004201 D-loop; other site 1194526004202 H-loop/switch region; other site 1194526004203 ABC transporter; Region: ABC_tran_2; pfam12848 1194526004204 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1194526004205 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1194526004206 S1 domain; Region: S1_2; pfam13509 1194526004207 PBP superfamily domain; Region: PBP_like_2; cl17296 1194526004208 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1194526004209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526004210 dimer interface [polypeptide binding]; other site 1194526004211 conserved gate region; other site 1194526004212 putative PBP binding loops; other site 1194526004213 ABC-ATPase subunit interface; other site 1194526004214 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1194526004215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526004216 dimer interface [polypeptide binding]; other site 1194526004217 conserved gate region; other site 1194526004218 ABC-ATPase subunit interface; other site 1194526004219 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1194526004220 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1194526004221 Walker A/P-loop; other site 1194526004222 ATP binding site [chemical binding]; other site 1194526004223 Q-loop/lid; other site 1194526004224 ABC transporter signature motif; other site 1194526004225 Walker B; other site 1194526004226 D-loop; other site 1194526004227 H-loop/switch region; other site 1194526004228 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1194526004229 PhoU domain; Region: PhoU; pfam01895 1194526004230 PhoU domain; Region: PhoU; pfam01895 1194526004231 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1194526004232 oligoendopeptidase F; Region: pepF; TIGR00181 1194526004233 active site 1194526004234 Zn binding site [ion binding]; other site 1194526004235 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1194526004236 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1194526004237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526004238 dimer interface [polypeptide binding]; other site 1194526004239 conserved gate region; other site 1194526004240 putative PBP binding loops; other site 1194526004241 ABC-ATPase subunit interface; other site 1194526004242 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1194526004243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526004244 dimer interface [polypeptide binding]; other site 1194526004245 conserved gate region; other site 1194526004246 putative PBP binding loops; other site 1194526004247 ABC-ATPase subunit interface; other site 1194526004248 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1194526004249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1194526004250 Walker A/P-loop; other site 1194526004251 ATP binding site [chemical binding]; other site 1194526004252 Q-loop/lid; other site 1194526004253 ABC transporter signature motif; other site 1194526004254 Walker B; other site 1194526004255 D-loop; other site 1194526004256 H-loop/switch region; other site 1194526004257 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1194526004258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1194526004259 Walker A/P-loop; other site 1194526004260 ATP binding site [chemical binding]; other site 1194526004261 Q-loop/lid; other site 1194526004262 ABC transporter signature motif; other site 1194526004263 Walker B; other site 1194526004264 D-loop; other site 1194526004265 H-loop/switch region; other site 1194526004266 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1194526004267 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1194526004268 intersubunit interface [polypeptide binding]; other site 1194526004269 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1194526004270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1194526004271 active site 1194526004272 motif I; other site 1194526004273 motif II; other site 1194526004274 FemAB family; Region: FemAB; pfam02388 1194526004275 FemAB family; Region: FemAB; pfam02388 1194526004276 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1194526004277 substrate binding site [chemical binding]; other site 1194526004278 active site 1194526004279 catalytic residues [active] 1194526004280 heterodimer interface [polypeptide binding]; other site 1194526004281 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1194526004282 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1194526004283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526004284 catalytic residue [active] 1194526004285 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1194526004286 active site 1194526004287 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1194526004288 active site 1194526004289 ribulose/triose binding site [chemical binding]; other site 1194526004290 phosphate binding site [ion binding]; other site 1194526004291 substrate (anthranilate) binding pocket [chemical binding]; other site 1194526004292 product (indole) binding pocket [chemical binding]; other site 1194526004293 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1194526004294 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1194526004295 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1194526004296 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1194526004297 glutamine binding [chemical binding]; other site 1194526004298 catalytic triad [active] 1194526004299 anthranilate synthase component I; Provisional; Region: PRK13567 1194526004300 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1194526004301 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1194526004302 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1194526004303 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1194526004304 putative oligomer interface [polypeptide binding]; other site 1194526004305 putative active site [active] 1194526004306 metal binding site [ion binding]; metal-binding site 1194526004307 prephenate dehydrogenase; Validated; Region: PRK06545 1194526004308 prephenate dehydrogenase; Validated; Region: PRK08507 1194526004309 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1194526004310 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1194526004311 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1194526004312 active site 1194526004313 DNA binding site [nucleotide binding] 1194526004314 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1194526004315 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1194526004316 active site 1 [active] 1194526004317 dimer interface [polypeptide binding]; other site 1194526004318 hexamer interface [polypeptide binding]; other site 1194526004319 active site 2 [active] 1194526004320 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1194526004321 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1194526004322 Predicted integral membrane protein [Function unknown]; Region: COG0392 1194526004323 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1194526004324 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1194526004325 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1194526004326 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1194526004327 CAT RNA binding domain; Region: CAT_RBD; smart01061 1194526004328 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1194526004329 PRD domain; Region: PRD; pfam00874 1194526004330 PRD domain; Region: PRD; pfam00874 1194526004331 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1194526004332 amino acid carrier protein; Region: agcS; TIGR00835 1194526004333 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1194526004334 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1194526004335 CAP-like domain; other site 1194526004336 active site 1194526004337 primary dimer interface [polypeptide binding]; other site 1194526004338 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1194526004339 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1194526004340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526004341 ATP binding site [chemical binding]; other site 1194526004342 Mg2+ binding site [ion binding]; other site 1194526004343 G-X-G motif; other site 1194526004344 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1194526004345 anchoring element; other site 1194526004346 dimer interface [polypeptide binding]; other site 1194526004347 ATP binding site [chemical binding]; other site 1194526004348 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1194526004349 active site 1194526004350 putative metal-binding site [ion binding]; other site 1194526004351 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1194526004352 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1194526004353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1194526004354 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1194526004355 active site 1194526004356 aconitate hydratase; Validated; Region: PRK09277 1194526004357 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1194526004358 substrate binding site [chemical binding]; other site 1194526004359 ligand binding site [chemical binding]; other site 1194526004360 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1194526004361 substrate binding site [chemical binding]; other site 1194526004362 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1194526004363 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1194526004364 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1194526004365 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1194526004366 AAA domain; Region: AAA_23; pfam13476 1194526004367 Walker A/P-loop; other site 1194526004368 ATP binding site [chemical binding]; other site 1194526004369 Q-loop/lid; other site 1194526004370 ABC transporter signature motif; other site 1194526004371 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1194526004372 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1194526004373 ABC transporter signature motif; other site 1194526004374 Walker B; other site 1194526004375 D-loop; other site 1194526004376 H-loop/switch region; other site 1194526004377 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1194526004378 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1194526004379 active site 1194526004380 metal binding site [ion binding]; metal-binding site 1194526004381 DNA binding site [nucleotide binding] 1194526004382 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1194526004383 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1194526004384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1194526004385 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1194526004386 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1194526004387 TPP-binding site [chemical binding]; other site 1194526004388 dimer interface [polypeptide binding]; other site 1194526004389 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1194526004390 PYR/PP interface [polypeptide binding]; other site 1194526004391 dimer interface [polypeptide binding]; other site 1194526004392 TPP binding site [chemical binding]; other site 1194526004393 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1194526004394 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1194526004395 LexA repressor; Validated; Region: PRK00215 1194526004396 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1194526004397 putative DNA binding site [nucleotide binding]; other site 1194526004398 putative Zn2+ binding site [ion binding]; other site 1194526004399 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1194526004400 Catalytic site [active] 1194526004401 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1194526004402 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1194526004403 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1194526004404 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1194526004405 active site 1194526004406 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1194526004407 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1194526004408 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1194526004409 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1194526004410 tetramer interface [polypeptide binding]; other site 1194526004411 heme binding pocket [chemical binding]; other site 1194526004412 NADPH binding site [chemical binding]; other site 1194526004413 lysine transporter; Provisional; Region: PRK10836 1194526004414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526004415 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1194526004416 active site 1194526004417 motif I; other site 1194526004418 motif II; other site 1194526004419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526004420 homoserine kinase; Provisional; Region: PRK01212 1194526004421 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1194526004422 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1194526004423 threonine synthase; Reviewed; Region: PRK06721 1194526004424 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1194526004425 homodimer interface [polypeptide binding]; other site 1194526004426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526004427 catalytic residue [active] 1194526004428 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1194526004429 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1194526004430 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1194526004431 aspartate kinase; Reviewed; Region: PRK09034 1194526004432 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1194526004433 putative catalytic residues [active] 1194526004434 putative nucleotide binding site [chemical binding]; other site 1194526004435 putative aspartate binding site [chemical binding]; other site 1194526004436 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1194526004437 allosteric regulatory residue; other site 1194526004438 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1194526004439 Staphylococcal nuclease homologues; Region: SNc; smart00318 1194526004440 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1194526004441 Catalytic site; other site 1194526004442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1194526004443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526004444 active site 1194526004445 phosphorylation site [posttranslational modification] 1194526004446 intermolecular recognition site; other site 1194526004447 dimerization interface [polypeptide binding]; other site 1194526004448 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1194526004449 DNA binding residues [nucleotide binding] 1194526004450 dimerization interface [polypeptide binding]; other site 1194526004451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1194526004452 Histidine kinase; Region: HisKA_3; pfam07730 1194526004453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526004454 ATP binding site [chemical binding]; other site 1194526004455 Mg2+ binding site [ion binding]; other site 1194526004456 G-X-G motif; other site 1194526004457 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1194526004458 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1194526004459 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1194526004460 Walker A/P-loop; other site 1194526004461 ATP binding site [chemical binding]; other site 1194526004462 Q-loop/lid; other site 1194526004463 ABC transporter signature motif; other site 1194526004464 Walker B; other site 1194526004465 D-loop; other site 1194526004466 H-loop/switch region; other site 1194526004467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526004468 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1194526004469 conserved gate region; other site 1194526004470 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1194526004471 putative active site [active] 1194526004472 catalytic site [active] 1194526004473 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1194526004474 putative active site [active] 1194526004475 catalytic site [active] 1194526004476 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1194526004477 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1194526004478 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1194526004479 catalytic residue [active] 1194526004480 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1194526004481 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1194526004482 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 1194526004483 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1194526004484 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1194526004485 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1194526004486 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1194526004487 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1194526004488 DNA binding residues [nucleotide binding] 1194526004489 putative dimer interface [polypeptide binding]; other site 1194526004490 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1194526004491 Aluminium resistance protein; Region: Alum_res; pfam06838 1194526004492 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1194526004493 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1194526004494 HflX GTPase family; Region: HflX; cd01878 1194526004495 G1 box; other site 1194526004496 GTP/Mg2+ binding site [chemical binding]; other site 1194526004497 Switch I region; other site 1194526004498 G2 box; other site 1194526004499 G3 box; other site 1194526004500 Switch II region; other site 1194526004501 G4 box; other site 1194526004502 G5 box; other site 1194526004503 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1194526004504 catalytic residues [active] 1194526004505 dimer interface [polypeptide binding]; other site 1194526004506 bacterial Hfq-like; Region: Hfq; cd01716 1194526004507 hexamer interface [polypeptide binding]; other site 1194526004508 Sm1 motif; other site 1194526004509 RNA binding site [nucleotide binding]; other site 1194526004510 Sm2 motif; other site 1194526004511 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1194526004512 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1194526004513 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1194526004514 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1194526004515 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1194526004516 glycerol kinase; Provisional; Region: glpK; PRK00047 1194526004517 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1194526004518 N- and C-terminal domain interface [polypeptide binding]; other site 1194526004519 active site 1194526004520 MgATP binding site [chemical binding]; other site 1194526004521 catalytic site [active] 1194526004522 metal binding site [ion binding]; metal-binding site 1194526004523 glycerol binding site [chemical binding]; other site 1194526004524 homotetramer interface [polypeptide binding]; other site 1194526004525 homodimer interface [polypeptide binding]; other site 1194526004526 FBP binding site [chemical binding]; other site 1194526004527 protein IIAGlc interface [polypeptide binding]; other site 1194526004528 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1194526004529 amphipathic channel; other site 1194526004530 Asn-Pro-Ala signature motifs; other site 1194526004531 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1194526004532 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1194526004533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526004534 ATP binding site [chemical binding]; other site 1194526004535 Mg2+ binding site [ion binding]; other site 1194526004536 G-X-G motif; other site 1194526004537 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1194526004538 ATP binding site [chemical binding]; other site 1194526004539 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1194526004540 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1194526004541 MutS domain I; Region: MutS_I; pfam01624 1194526004542 MutS domain II; Region: MutS_II; pfam05188 1194526004543 MutS domain III; Region: MutS_III; pfam05192 1194526004544 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1194526004545 Walker A/P-loop; other site 1194526004546 ATP binding site [chemical binding]; other site 1194526004547 Q-loop/lid; other site 1194526004548 ABC transporter signature motif; other site 1194526004549 Walker B; other site 1194526004550 D-loop; other site 1194526004551 H-loop/switch region; other site 1194526004552 thiW protein; Region: thiW; TIGR02359 1194526004553 Predicted membrane protein [Function unknown]; Region: COG4550 1194526004554 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1194526004555 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1194526004556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1194526004557 FeS/SAM binding site; other site 1194526004558 TRAM domain; Region: TRAM; pfam01938 1194526004559 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1194526004560 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1194526004561 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1194526004562 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1194526004563 TPP-binding site [chemical binding]; other site 1194526004564 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1194526004565 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1194526004566 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1194526004567 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1194526004568 dimer interface [polypeptide binding]; other site 1194526004569 PYR/PP interface [polypeptide binding]; other site 1194526004570 TPP binding site [chemical binding]; other site 1194526004571 substrate binding site [chemical binding]; other site 1194526004572 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1194526004573 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1194526004574 putative active site [active] 1194526004575 metal binding site [ion binding]; metal-binding site 1194526004576 homodimer binding site [polypeptide binding]; other site 1194526004577 phosphodiesterase; Provisional; Region: PRK12704 1194526004578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1194526004579 Zn2+ binding site [ion binding]; other site 1194526004580 Mg2+ binding site [ion binding]; other site 1194526004581 recombinase A; Provisional; Region: recA; PRK09354 1194526004582 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1194526004583 hexamer interface [polypeptide binding]; other site 1194526004584 Walker A motif; other site 1194526004585 ATP binding site [chemical binding]; other site 1194526004586 Walker B motif; other site 1194526004587 competence damage-inducible protein A; Provisional; Region: PRK00549 1194526004588 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1194526004589 putative MPT binding site; other site 1194526004590 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1194526004591 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1194526004592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1194526004593 non-specific DNA binding site [nucleotide binding]; other site 1194526004594 salt bridge; other site 1194526004595 sequence-specific DNA binding site [nucleotide binding]; other site 1194526004596 ACT domain; Region: ACT; pfam01842 1194526004597 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1194526004598 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1194526004599 classical (c) SDRs; Region: SDR_c; cd05233 1194526004600 NAD(P) binding site [chemical binding]; other site 1194526004601 active site 1194526004602 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1194526004603 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1194526004604 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1194526004605 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1194526004606 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1194526004607 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1194526004608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1194526004609 DNA-binding site [nucleotide binding]; DNA binding site 1194526004610 UTRA domain; Region: UTRA; pfam07702 1194526004611 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1194526004612 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1194526004613 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1194526004614 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1194526004615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1194526004616 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1194526004617 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1194526004618 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1194526004619 RNase E interface [polypeptide binding]; other site 1194526004620 trimer interface [polypeptide binding]; other site 1194526004621 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1194526004622 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1194526004623 RNase E interface [polypeptide binding]; other site 1194526004624 trimer interface [polypeptide binding]; other site 1194526004625 active site 1194526004626 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1194526004627 putative nucleic acid binding region [nucleotide binding]; other site 1194526004628 G-X-X-G motif; other site 1194526004629 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1194526004630 RNA binding site [nucleotide binding]; other site 1194526004631 domain interface; other site 1194526004632 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1194526004633 16S/18S rRNA binding site [nucleotide binding]; other site 1194526004634 S13e-L30e interaction site [polypeptide binding]; other site 1194526004635 25S rRNA binding site [nucleotide binding]; other site 1194526004636 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1194526004637 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1194526004638 active site 1194526004639 Riboflavin kinase; Region: Flavokinase; pfam01687 1194526004640 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1194526004641 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1194526004642 RNA binding site [nucleotide binding]; other site 1194526004643 active site 1194526004644 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1194526004645 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1194526004646 translation initiation factor IF-2; Region: IF-2; TIGR00487 1194526004647 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1194526004648 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1194526004649 G1 box; other site 1194526004650 putative GEF interaction site [polypeptide binding]; other site 1194526004651 GTP/Mg2+ binding site [chemical binding]; other site 1194526004652 Switch I region; other site 1194526004653 G2 box; other site 1194526004654 G3 box; other site 1194526004655 Switch II region; other site 1194526004656 G4 box; other site 1194526004657 G5 box; other site 1194526004658 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1194526004659 Translation-initiation factor 2; Region: IF-2; pfam11987 1194526004660 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1194526004661 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1194526004662 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1194526004663 putative RNA binding cleft [nucleotide binding]; other site 1194526004664 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1194526004665 NusA N-terminal domain; Region: NusA_N; pfam08529 1194526004666 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1194526004667 RNA binding site [nucleotide binding]; other site 1194526004668 homodimer interface [polypeptide binding]; other site 1194526004669 NusA-like KH domain; Region: KH_5; pfam13184 1194526004670 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1194526004671 G-X-X-G motif; other site 1194526004672 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1194526004673 Sm and related proteins; Region: Sm_like; cl00259 1194526004674 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1194526004675 putative oligomer interface [polypeptide binding]; other site 1194526004676 putative RNA binding site [nucleotide binding]; other site 1194526004677 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1194526004678 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1194526004679 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1194526004680 generic binding surface II; other site 1194526004681 generic binding surface I; other site 1194526004682 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1194526004683 active site 1194526004684 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1194526004685 active site 1194526004686 catalytic site [active] 1194526004687 substrate binding site [chemical binding]; other site 1194526004688 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1194526004689 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1194526004690 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1194526004691 dimer interface [polypeptide binding]; other site 1194526004692 motif 1; other site 1194526004693 active site 1194526004694 motif 2; other site 1194526004695 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1194526004696 putative deacylase active site [active] 1194526004697 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1194526004698 active site 1194526004699 motif 3; other site 1194526004700 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1194526004701 anticodon binding site; other site 1194526004702 RIP metalloprotease RseP; Region: TIGR00054 1194526004703 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1194526004704 active site 1194526004705 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1194526004706 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1194526004707 protein binding site [polypeptide binding]; other site 1194526004708 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1194526004709 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1194526004710 putative substrate binding region [chemical binding]; other site 1194526004711 putative substrate binding region [chemical binding]; other site 1194526004712 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1194526004713 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1194526004714 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1194526004715 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1194526004716 catalytic residue [active] 1194526004717 putative FPP diphosphate binding site; other site 1194526004718 putative FPP binding hydrophobic cleft; other site 1194526004719 dimer interface [polypeptide binding]; other site 1194526004720 putative IPP diphosphate binding site; other site 1194526004721 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1194526004722 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1194526004723 hinge region; other site 1194526004724 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1194526004725 putative nucleotide binding site [chemical binding]; other site 1194526004726 uridine monophosphate binding site [chemical binding]; other site 1194526004727 homohexameric interface [polypeptide binding]; other site 1194526004728 elongation factor Ts; Provisional; Region: tsf; PRK09377 1194526004729 UBA/TS-N domain; Region: UBA; pfam00627 1194526004730 Elongation factor TS; Region: EF_TS; pfam00889 1194526004731 Elongation factor TS; Region: EF_TS; pfam00889 1194526004732 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1194526004733 rRNA interaction site [nucleotide binding]; other site 1194526004734 S8 interaction site; other site 1194526004735 putative laminin-1 binding site; other site 1194526004736 transcriptional repressor CodY; Validated; Region: PRK04158 1194526004737 CodY GAF-like domain; Region: CodY; pfam06018 1194526004738 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1194526004739 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1194526004740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526004741 Walker A motif; other site 1194526004742 ATP binding site [chemical binding]; other site 1194526004743 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1194526004744 Walker B motif; other site 1194526004745 arginine finger; other site 1194526004746 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1194526004747 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1194526004748 active site 1194526004749 HslU subunit interaction site [polypeptide binding]; other site 1194526004750 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1194526004751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1194526004752 active site 1194526004753 DNA binding site [nucleotide binding] 1194526004754 Int/Topo IB signature motif; other site 1194526004755 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1194526004756 Glucose inhibited division protein A; Region: GIDA; pfam01134 1194526004757 DNA topoisomerase I; Validated; Region: PRK05582 1194526004758 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1194526004759 active site 1194526004760 interdomain interaction site; other site 1194526004761 putative metal-binding site [ion binding]; other site 1194526004762 nucleotide binding site [chemical binding]; other site 1194526004763 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1194526004764 domain I; other site 1194526004765 DNA binding groove [nucleotide binding] 1194526004766 phosphate binding site [ion binding]; other site 1194526004767 domain II; other site 1194526004768 domain III; other site 1194526004769 nucleotide binding site [chemical binding]; other site 1194526004770 catalytic site [active] 1194526004771 domain IV; other site 1194526004772 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1194526004773 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1194526004774 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1194526004775 DNA protecting protein DprA; Region: dprA; TIGR00732 1194526004776 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1194526004777 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1194526004778 CoA binding domain; Region: CoA_binding; pfam02629 1194526004779 CoA-ligase; Region: Ligase_CoA; pfam00549 1194526004780 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1194526004781 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1194526004782 CoA-ligase; Region: Ligase_CoA; pfam00549 1194526004783 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1194526004784 RNA/DNA hybrid binding site [nucleotide binding]; other site 1194526004785 active site 1194526004786 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1194526004787 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1194526004788 GTP/Mg2+ binding site [chemical binding]; other site 1194526004789 G4 box; other site 1194526004790 G5 box; other site 1194526004791 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1194526004792 G1 box; other site 1194526004793 G1 box; other site 1194526004794 GTP/Mg2+ binding site [chemical binding]; other site 1194526004795 Switch I region; other site 1194526004796 G2 box; other site 1194526004797 G2 box; other site 1194526004798 G3 box; other site 1194526004799 G3 box; other site 1194526004800 Switch II region; other site 1194526004801 Switch II region; other site 1194526004802 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1194526004803 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1194526004804 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1194526004805 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1194526004806 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1194526004807 RimM N-terminal domain; Region: RimM; pfam01782 1194526004808 PRC-barrel domain; Region: PRC; pfam05239 1194526004809 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1194526004810 signal recognition particle protein; Provisional; Region: PRK10867 1194526004811 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1194526004812 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1194526004813 P loop; other site 1194526004814 GTP binding site [chemical binding]; other site 1194526004815 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1194526004816 putative DNA-binding protein; Validated; Region: PRK00118 1194526004817 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1194526004818 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1194526004819 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1194526004820 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1194526004821 P loop; other site 1194526004822 GTP binding site [chemical binding]; other site 1194526004823 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1194526004824 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1194526004825 Walker A/P-loop; other site 1194526004826 ATP binding site [chemical binding]; other site 1194526004827 Q-loop/lid; other site 1194526004828 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1194526004829 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1194526004830 ABC transporter signature motif; other site 1194526004831 Walker B; other site 1194526004832 D-loop; other site 1194526004833 H-loop/switch region; other site 1194526004834 ribonuclease III; Reviewed; Region: rnc; PRK00102 1194526004835 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1194526004836 dimerization interface [polypeptide binding]; other site 1194526004837 active site 1194526004838 metal binding site [ion binding]; metal-binding site 1194526004839 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1194526004840 dsRNA binding site [nucleotide binding]; other site 1194526004841 acyl carrier protein; Provisional; Region: acpP; PRK00982 1194526004842 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1194526004843 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1194526004844 NAD(P) binding site [chemical binding]; other site 1194526004845 homotetramer interface [polypeptide binding]; other site 1194526004846 homodimer interface [polypeptide binding]; other site 1194526004847 active site 1194526004848 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1194526004849 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1194526004850 putative phosphate acyltransferase; Provisional; Region: PRK05331 1194526004851 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1194526004852 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1194526004853 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1194526004854 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1194526004855 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1194526004856 generic binding surface II; other site 1194526004857 ssDNA binding site; other site 1194526004858 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1194526004859 ATP binding site [chemical binding]; other site 1194526004860 putative Mg++ binding site [ion binding]; other site 1194526004861 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526004862 nucleotide binding region [chemical binding]; other site 1194526004863 ATP-binding site [chemical binding]; other site 1194526004864 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1194526004865 DAK2 domain; Region: Dak2; pfam02734 1194526004866 RimM N-terminal domain; Region: RimM; pfam01782 1194526004867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1194526004868 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1194526004869 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1194526004870 Thiamine pyrophosphokinase; Region: TPK; cd07995 1194526004871 active site 1194526004872 dimerization interface [polypeptide binding]; other site 1194526004873 thiamine binding site [chemical binding]; other site 1194526004874 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1194526004875 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1194526004876 substrate binding site [chemical binding]; other site 1194526004877 hexamer interface [polypeptide binding]; other site 1194526004878 metal binding site [ion binding]; metal-binding site 1194526004879 GTPase RsgA; Reviewed; Region: PRK00098 1194526004880 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1194526004881 RNA binding site [nucleotide binding]; other site 1194526004882 homodimer interface [polypeptide binding]; other site 1194526004883 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1194526004884 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1194526004885 GTP/Mg2+ binding site [chemical binding]; other site 1194526004886 G4 box; other site 1194526004887 G5 box; other site 1194526004888 G1 box; other site 1194526004889 Switch I region; other site 1194526004890 G2 box; other site 1194526004891 G3 box; other site 1194526004892 Switch II region; other site 1194526004893 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1194526004894 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1194526004895 active site 1194526004896 ATP binding site [chemical binding]; other site 1194526004897 substrate binding site [chemical binding]; other site 1194526004898 activation loop (A-loop); other site 1194526004899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1194526004900 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1194526004901 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1194526004902 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1194526004903 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1194526004904 Protein phosphatase 2C; Region: PP2C; pfam00481 1194526004905 active site 1194526004906 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1194526004907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1194526004908 FeS/SAM binding site; other site 1194526004909 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1194526004910 NusB family; Region: NusB; pfam01029 1194526004911 putative RNA binding site [nucleotide binding]; other site 1194526004912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526004913 S-adenosylmethionine binding site [chemical binding]; other site 1194526004914 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1194526004915 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1194526004916 putative active site [active] 1194526004917 substrate binding site [chemical binding]; other site 1194526004918 putative cosubstrate binding site; other site 1194526004919 catalytic site [active] 1194526004920 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1194526004921 substrate binding site [chemical binding]; other site 1194526004922 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1194526004923 active site 1194526004924 catalytic residues [active] 1194526004925 metal binding site [ion binding]; metal-binding site 1194526004926 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1194526004927 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1194526004928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1194526004929 ATP binding site [chemical binding]; other site 1194526004930 putative Mg++ binding site [ion binding]; other site 1194526004931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526004932 nucleotide binding region [chemical binding]; other site 1194526004933 ATP-binding site [chemical binding]; other site 1194526004934 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1194526004935 Flavoprotein; Region: Flavoprotein; pfam02441 1194526004936 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1194526004937 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1194526004938 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1194526004939 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1194526004940 catalytic site [active] 1194526004941 G-X2-G-X-G-K; other site 1194526004942 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1194526004943 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1194526004944 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1194526004945 dimer interface [polypeptide binding]; other site 1194526004946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526004947 active site 1194526004948 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1194526004949 active site 1194526004950 dimer interface [polypeptide binding]; other site 1194526004951 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1194526004952 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1194526004953 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1194526004954 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1194526004955 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1194526004956 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1194526004957 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1194526004958 IMP binding site; other site 1194526004959 dimer interface [polypeptide binding]; other site 1194526004960 interdomain contacts; other site 1194526004961 partial ornithine binding site; other site 1194526004962 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1194526004963 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1194526004964 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1194526004965 catalytic site [active] 1194526004966 subunit interface [polypeptide binding]; other site 1194526004967 dihydroorotase; Validated; Region: pyrC; PRK09357 1194526004968 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1194526004969 active site 1194526004970 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1194526004971 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1194526004972 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1194526004973 uracil transporter; Provisional; Region: PRK10720 1194526004974 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1194526004975 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526004976 active site 1194526004977 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1194526004978 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1194526004979 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1194526004980 RNA binding surface [nucleotide binding]; other site 1194526004981 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1194526004982 active site 1194526004983 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1194526004984 lipoprotein signal peptidase; Provisional; Region: PRK14787 1194526004985 CHAP domain; Region: CHAP; pfam05257 1194526004986 Surface antigen [General function prediction only]; Region: COG3942 1194526004987 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1194526004988 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1194526004989 active site 1194526004990 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1194526004991 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1194526004992 HIGH motif; other site 1194526004993 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1194526004994 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1194526004995 active site 1194526004996 KMSKS motif; other site 1194526004997 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1194526004998 tRNA binding surface [nucleotide binding]; other site 1194526004999 anticodon binding site; other site 1194526005000 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1194526005001 DivIVA protein; Region: DivIVA; pfam05103 1194526005002 DivIVA domain; Region: DivI1A_domain; TIGR03544 1194526005003 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1194526005004 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1194526005005 RNA binding surface [nucleotide binding]; other site 1194526005006 YGGT family; Region: YGGT; pfam02325 1194526005007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1194526005008 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1194526005009 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1194526005010 catalytic residue [active] 1194526005011 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1194526005012 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1194526005013 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1194526005014 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1194526005015 nucleotide binding site [chemical binding]; other site 1194526005016 SulA interaction site; other site 1194526005017 cell division protein FtsA; Region: ftsA; TIGR01174 1194526005018 Cell division protein FtsA; Region: FtsA; smart00842 1194526005019 Cell division protein FtsA; Region: FtsA; pfam14450 1194526005020 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1194526005021 Cell division protein FtsQ; Region: FtsQ; pfam03799 1194526005022 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1194526005023 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1194526005024 NAD binding site [chemical binding]; other site 1194526005025 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1194526005026 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1194526005027 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1194526005028 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1194526005029 Mg++ binding site [ion binding]; other site 1194526005030 putative catalytic motif [active] 1194526005031 putative substrate binding site [chemical binding]; other site 1194526005032 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1194526005033 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1194526005034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1194526005035 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1194526005036 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1194526005037 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1194526005038 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1194526005039 MraW methylase family; Region: Methyltransf_5; pfam01795 1194526005040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1194526005041 MraZ protein; Region: MraZ; pfam02381 1194526005042 MraZ protein; Region: MraZ; pfam02381 1194526005043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1194526005044 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1194526005045 hypothetical protein; Provisional; Region: PRK13688 1194526005046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1194526005047 Coenzyme A binding pocket [chemical binding]; other site 1194526005048 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1194526005049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526005050 motif II; other site 1194526005051 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1194526005052 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1194526005053 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1194526005054 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1194526005055 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1194526005056 Fic family protein [Function unknown]; Region: COG3177 1194526005057 Fic/DOC family; Region: Fic; pfam02661 1194526005058 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1194526005059 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1194526005060 amidase catalytic site [active] 1194526005061 Zn binding residues [ion binding]; other site 1194526005062 substrate binding site [chemical binding]; other site 1194526005063 CHAP domain; Region: CHAP; pfam05257 1194526005064 Phage lysis protein, holin; Region: Phage_holin; cl04675 1194526005065 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1194526005066 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1194526005067 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1194526005068 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1194526005069 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1194526005070 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1194526005071 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1194526005072 Phage tail protein; Region: Sipho_tail; pfam05709 1194526005073 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 1194526005074 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1194526005075 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cd07307 1194526005076 dimer interface [polypeptide binding]; other site 1194526005077 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1194526005078 Peptidase family M23; Region: Peptidase_M23; pfam01551 1194526005079 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1194526005080 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1194526005081 catalytic residue [active] 1194526005082 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1194526005083 Interdomain contacts; other site 1194526005084 Cytokine receptor motif; other site 1194526005085 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1194526005086 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1194526005087 oligomerization interface [polypeptide binding]; other site 1194526005088 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1194526005089 Phage capsid family; Region: Phage_capsid; pfam05065 1194526005090 Clp protease; Region: CLP_protease; pfam00574 1194526005091 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1194526005092 oligomer interface [polypeptide binding]; other site 1194526005093 active site residues [active] 1194526005094 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1194526005095 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1194526005096 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1194526005097 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1194526005098 HNH endonuclease; Region: HNH; pfam01844 1194526005099 active site 1194526005100 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1194526005101 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1194526005102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1194526005103 non-specific DNA binding site [nucleotide binding]; other site 1194526005104 salt bridge; other site 1194526005105 sequence-specific DNA binding site [nucleotide binding]; other site 1194526005106 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1194526005107 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1194526005108 trimer interface [polypeptide binding]; other site 1194526005109 active site 1194526005110 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1194526005111 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1194526005112 Catalytic site; other site 1194526005113 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 1194526005114 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1194526005115 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 1194526005116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526005117 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1194526005118 Walker A motif; other site 1194526005119 ATP binding site [chemical binding]; other site 1194526005120 Walker B motif; other site 1194526005121 arginine finger; other site 1194526005122 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1194526005123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1194526005124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1194526005125 non-specific DNA binding site [nucleotide binding]; other site 1194526005126 salt bridge; other site 1194526005127 sequence-specific DNA binding site [nucleotide binding]; other site 1194526005128 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1194526005129 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1194526005130 AAA domain; Region: AAA_24; pfam13479 1194526005131 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1194526005132 Domain of unknown function (DUF771); Region: DUF771; cl09962 1194526005133 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 1194526005134 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1194526005135 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1194526005136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1194526005137 non-specific DNA binding site [nucleotide binding]; other site 1194526005138 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1194526005139 salt bridge; other site 1194526005140 sequence-specific DNA binding site [nucleotide binding]; other site 1194526005141 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1194526005142 Catalytic site [active] 1194526005143 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1194526005144 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1194526005145 Int/Topo IB signature motif; other site 1194526005146 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1194526005147 active site 1194526005148 metal binding site [ion binding]; metal-binding site 1194526005149 homotetramer interface [polypeptide binding]; other site 1194526005150 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1194526005151 active site 1194526005152 dimerization interface [polypeptide binding]; other site 1194526005153 glutamate racemase; Provisional; Region: PRK00865 1194526005154 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1194526005155 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1194526005156 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1194526005157 L-aspartate oxidase; Provisional; Region: PRK06175 1194526005158 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1194526005159 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1194526005160 putative Iron-sulfur protein interface [polypeptide binding]; other site 1194526005161 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1194526005162 proximal heme binding site [chemical binding]; other site 1194526005163 distal heme binding site [chemical binding]; other site 1194526005164 putative dimer interface [polypeptide binding]; other site 1194526005165 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1194526005166 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1194526005167 GIY-YIG motif/motif A; other site 1194526005168 active site 1194526005169 catalytic site [active] 1194526005170 putative DNA binding site [nucleotide binding]; other site 1194526005171 metal binding site [ion binding]; metal-binding site 1194526005172 UvrB/uvrC motif; Region: UVR; pfam02151 1194526005173 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1194526005174 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1194526005175 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1194526005176 catalytic residues [active] 1194526005177 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1194526005178 MutS domain III; Region: MutS_III; pfam05192 1194526005179 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1194526005180 Walker A/P-loop; other site 1194526005181 ATP binding site [chemical binding]; other site 1194526005182 Q-loop/lid; other site 1194526005183 ABC transporter signature motif; other site 1194526005184 Walker B; other site 1194526005185 D-loop; other site 1194526005186 H-loop/switch region; other site 1194526005187 Smr domain; Region: Smr; pfam01713 1194526005188 hypothetical protein; Provisional; Region: PRK08609 1194526005189 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1194526005190 active site 1194526005191 primer binding site [nucleotide binding]; other site 1194526005192 NTP binding site [chemical binding]; other site 1194526005193 metal binding triad [ion binding]; metal-binding site 1194526005194 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1194526005195 active site 1194526005196 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1194526005197 Colicin V production protein; Region: Colicin_V; pfam02674 1194526005198 Cell division protein ZapA; Region: ZapA; cl01146 1194526005199 ribonuclease HIII; Provisional; Region: PRK00996 1194526005200 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1194526005201 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1194526005202 RNA/DNA hybrid binding site [nucleotide binding]; other site 1194526005203 active site 1194526005204 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1194526005205 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1194526005206 putative tRNA-binding site [nucleotide binding]; other site 1194526005207 B3/4 domain; Region: B3_4; pfam03483 1194526005208 tRNA synthetase B5 domain; Region: B5; smart00874 1194526005209 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1194526005210 dimer interface [polypeptide binding]; other site 1194526005211 motif 1; other site 1194526005212 motif 3; other site 1194526005213 motif 2; other site 1194526005214 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1194526005215 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1194526005216 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1194526005217 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1194526005218 dimer interface [polypeptide binding]; other site 1194526005219 motif 1; other site 1194526005220 active site 1194526005221 motif 2; other site 1194526005222 motif 3; other site 1194526005223 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1194526005224 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1194526005225 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1194526005226 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1194526005227 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1194526005228 hypothetical protein; Provisional; Region: PRK13670 1194526005229 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1194526005230 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1194526005231 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1194526005232 active site 1194526005233 (T/H)XGH motif; other site 1194526005234 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1194526005235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526005236 S-adenosylmethionine binding site [chemical binding]; other site 1194526005237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1194526005238 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1194526005239 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1194526005240 putative active site [active] 1194526005241 catalytic site [active] 1194526005242 putative metal binding site [ion binding]; other site 1194526005243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1194526005244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1194526005245 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1194526005246 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1194526005247 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1194526005248 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1194526005249 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1194526005250 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1194526005251 UbiA prenyltransferase family; Region: UbiA; pfam01040 1194526005252 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1194526005253 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1194526005254 pyruvate carboxylase; Reviewed; Region: PRK12999 1194526005255 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1194526005256 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1194526005257 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1194526005258 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1194526005259 active site 1194526005260 catalytic residues [active] 1194526005261 metal binding site [ion binding]; metal-binding site 1194526005262 homodimer binding site [polypeptide binding]; other site 1194526005263 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1194526005264 carboxyltransferase (CT) interaction site; other site 1194526005265 biotinylation site [posttranslational modification]; other site 1194526005266 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1194526005267 hypothetical protein; Provisional; Region: PRK13666 1194526005268 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1194526005269 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1194526005270 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1194526005271 G1 box; other site 1194526005272 putative GEF interaction site [polypeptide binding]; other site 1194526005273 GTP/Mg2+ binding site [chemical binding]; other site 1194526005274 Switch I region; other site 1194526005275 G2 box; other site 1194526005276 G3 box; other site 1194526005277 Switch II region; other site 1194526005278 G4 box; other site 1194526005279 G5 box; other site 1194526005280 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1194526005281 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1194526005282 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1194526005283 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1194526005284 active site 1194526005285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1194526005286 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1194526005287 manganese transport protein MntH; Reviewed; Region: PRK00701 1194526005288 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1194526005289 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1194526005290 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1194526005291 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1194526005292 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1194526005293 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1194526005294 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1194526005295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526005296 dimer interface [polypeptide binding]; other site 1194526005297 conserved gate region; other site 1194526005298 putative PBP binding loops; other site 1194526005299 ABC-ATPase subunit interface; other site 1194526005300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526005301 dimer interface [polypeptide binding]; other site 1194526005302 conserved gate region; other site 1194526005303 putative PBP binding loops; other site 1194526005304 ABC-ATPase subunit interface; other site 1194526005305 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1194526005306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526005307 Walker A/P-loop; other site 1194526005308 ATP binding site [chemical binding]; other site 1194526005309 Q-loop/lid; other site 1194526005310 ABC transporter signature motif; other site 1194526005311 Walker B; other site 1194526005312 D-loop; other site 1194526005313 H-loop/switch region; other site 1194526005314 TOBE domain; Region: TOBE_2; pfam08402 1194526005315 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1194526005316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1194526005317 non-specific DNA binding site [nucleotide binding]; other site 1194526005318 salt bridge; other site 1194526005319 sequence-specific DNA binding site [nucleotide binding]; other site 1194526005320 Cupin domain; Region: Cupin_2; pfam07883 1194526005321 hypothetical protein; Provisional; Region: PRK04387 1194526005322 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1194526005323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1194526005324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526005325 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1194526005326 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1194526005327 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1194526005328 E3 interaction surface; other site 1194526005329 lipoyl attachment site [posttranslational modification]; other site 1194526005330 e3 binding domain; Region: E3_binding; pfam02817 1194526005331 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1194526005332 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1194526005333 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1194526005334 alpha subunit interface [polypeptide binding]; other site 1194526005335 TPP binding site [chemical binding]; other site 1194526005336 heterodimer interface [polypeptide binding]; other site 1194526005337 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1194526005338 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1194526005339 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1194526005340 TPP-binding site [chemical binding]; other site 1194526005341 tetramer interface [polypeptide binding]; other site 1194526005342 heterodimer interface [polypeptide binding]; other site 1194526005343 phosphorylation loop region [posttranslational modification] 1194526005344 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1194526005345 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1194526005346 active site 1194526005347 catalytic residues [active] 1194526005348 metal binding site [ion binding]; metal-binding site 1194526005349 hypothetical protein; Provisional; Region: PRK13667 1194526005350 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1194526005351 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1194526005352 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1194526005353 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1194526005354 TrkA-N domain; Region: TrkA_N; pfam02254 1194526005355 TrkA-C domain; Region: TrkA_C; pfam02080 1194526005356 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1194526005357 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1194526005358 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1194526005359 catalytic residues [active] 1194526005360 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1194526005361 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1194526005362 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1194526005363 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1194526005364 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1194526005365 dimerization domain swap beta strand [polypeptide binding]; other site 1194526005366 regulatory protein interface [polypeptide binding]; other site 1194526005367 active site 1194526005368 regulatory phosphorylation site [posttranslational modification]; other site 1194526005369 Domain of unknown function (DUF697); Region: DUF697; cl12064 1194526005370 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1194526005371 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1194526005372 putative RNA binding site [nucleotide binding]; other site 1194526005373 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1194526005374 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1194526005375 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1194526005376 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1194526005377 Walker A/P-loop; other site 1194526005378 ATP binding site [chemical binding]; other site 1194526005379 Q-loop/lid; other site 1194526005380 ABC transporter signature motif; other site 1194526005381 Walker B; other site 1194526005382 D-loop; other site 1194526005383 H-loop/switch region; other site 1194526005384 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1194526005385 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1194526005386 Walker A/P-loop; other site 1194526005387 ATP binding site [chemical binding]; other site 1194526005388 Q-loop/lid; other site 1194526005389 ABC transporter signature motif; other site 1194526005390 Walker B; other site 1194526005391 D-loop; other site 1194526005392 H-loop/switch region; other site 1194526005393 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1194526005394 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1194526005395 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1194526005396 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1194526005397 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1194526005398 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1194526005399 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1194526005400 purine monophosphate binding site [chemical binding]; other site 1194526005401 dimer interface [polypeptide binding]; other site 1194526005402 putative catalytic residues [active] 1194526005403 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1194526005404 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1194526005405 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1194526005406 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1194526005407 active site 1194526005408 substrate binding site [chemical binding]; other site 1194526005409 cosubstrate binding site; other site 1194526005410 catalytic site [active] 1194526005411 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1194526005412 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1194526005413 dimerization interface [polypeptide binding]; other site 1194526005414 putative ATP binding site [chemical binding]; other site 1194526005415 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1194526005416 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1194526005417 active site 1194526005418 tetramer interface [polypeptide binding]; other site 1194526005419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526005420 active site 1194526005421 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1194526005422 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1194526005423 dimerization interface [polypeptide binding]; other site 1194526005424 ATP binding site [chemical binding]; other site 1194526005425 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1194526005426 dimerization interface [polypeptide binding]; other site 1194526005427 ATP binding site [chemical binding]; other site 1194526005428 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1194526005429 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1194526005430 putative active site [active] 1194526005431 catalytic triad [active] 1194526005432 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1194526005433 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1194526005434 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1194526005435 ATP binding site [chemical binding]; other site 1194526005436 active site 1194526005437 substrate binding site [chemical binding]; other site 1194526005438 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1194526005439 ATP-grasp domain; Region: ATP-grasp; pfam02222 1194526005440 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1194526005441 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1194526005442 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1194526005443 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1194526005444 homodimer interface [polypeptide binding]; other site 1194526005445 NADP binding site [chemical binding]; other site 1194526005446 substrate binding site [chemical binding]; other site 1194526005447 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1194526005448 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1194526005449 heme-binding site [chemical binding]; other site 1194526005450 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1194526005451 FAD binding pocket [chemical binding]; other site 1194526005452 FAD binding motif [chemical binding]; other site 1194526005453 phosphate binding motif [ion binding]; other site 1194526005454 beta-alpha-beta structure motif; other site 1194526005455 NAD binding pocket [chemical binding]; other site 1194526005456 Heme binding pocket [chemical binding]; other site 1194526005457 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1194526005458 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1194526005459 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1194526005460 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1194526005461 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1194526005462 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1194526005463 D-pathway; other site 1194526005464 Putative ubiquinol binding site [chemical binding]; other site 1194526005465 Low-spin heme (heme b) binding site [chemical binding]; other site 1194526005466 Putative water exit pathway; other site 1194526005467 Binuclear center (heme o3/CuB) [ion binding]; other site 1194526005468 K-pathway; other site 1194526005469 Putative proton exit pathway; other site 1194526005470 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1194526005471 Subunit I/III interface [polypeptide binding]; other site 1194526005472 Subunit III/IV interface [polypeptide binding]; other site 1194526005473 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1194526005474 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1194526005475 active site 1194526005476 tetramer interface [polypeptide binding]; other site 1194526005477 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1194526005478 Beta-lactamase; Region: Beta-lactamase; pfam00144 1194526005479 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1194526005480 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1194526005481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526005482 Coenzyme A binding pocket [chemical binding]; other site 1194526005483 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1194526005484 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1194526005485 amidase catalytic site [active] 1194526005486 Zn binding residues [ion binding]; other site 1194526005487 substrate binding site [chemical binding]; other site 1194526005488 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1194526005489 Lysozyme subfamily 2; Region: LYZ2; smart00047 1194526005490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1194526005491 MarR family; Region: MarR; pfam01047 1194526005492 MarR family; Region: MarR_2; cl17246 1194526005493 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1194526005494 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1194526005495 aminotransferase A; Validated; Region: PRK07683 1194526005496 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1194526005497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526005498 homodimer interface [polypeptide binding]; other site 1194526005499 catalytic residue [active] 1194526005500 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1194526005501 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1194526005502 substrate binding site [chemical binding]; other site 1194526005503 oxyanion hole (OAH) forming residues; other site 1194526005504 trimer interface [polypeptide binding]; other site 1194526005505 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1194526005506 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1194526005507 nucleophilic elbow; other site 1194526005508 catalytic triad; other site 1194526005509 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1194526005510 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1194526005511 dimer interface [polypeptide binding]; other site 1194526005512 tetramer interface [polypeptide binding]; other site 1194526005513 PYR/PP interface [polypeptide binding]; other site 1194526005514 TPP binding site [chemical binding]; other site 1194526005515 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1194526005516 TPP-binding site; other site 1194526005517 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1194526005518 isochorismate synthases; Region: isochor_syn; TIGR00543 1194526005519 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1194526005520 UbiA prenyltransferase family; Region: UbiA; pfam01040 1194526005521 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1194526005522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526005523 Coenzyme A binding pocket [chemical binding]; other site 1194526005524 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1194526005525 Predicted membrane protein [Function unknown]; Region: COG2259 1194526005526 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1194526005527 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1194526005528 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1194526005529 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1194526005530 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1194526005531 CAAX protease self-immunity; Region: Abi; cl00558 1194526005532 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1194526005533 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1194526005534 active site 1194526005535 metal binding site [ion binding]; metal-binding site 1194526005536 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1194526005537 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1194526005538 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1194526005539 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1194526005540 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1194526005541 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1194526005542 protein binding site [polypeptide binding]; other site 1194526005543 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1194526005544 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1194526005545 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1194526005546 G1 box; other site 1194526005547 putative GEF interaction site [polypeptide binding]; other site 1194526005548 GTP/Mg2+ binding site [chemical binding]; other site 1194526005549 Switch I region; other site 1194526005550 G2 box; other site 1194526005551 G3 box; other site 1194526005552 Switch II region; other site 1194526005553 G4 box; other site 1194526005554 G5 box; other site 1194526005555 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1194526005556 YueH-like protein; Region: YueH; pfam14166 1194526005557 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1194526005558 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1194526005559 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1194526005560 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1194526005561 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1194526005562 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1194526005563 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1194526005564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526005565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1194526005566 putative substrate translocation pore; other site 1194526005567 hypothetical protein; Provisional; Region: PRK13679 1194526005568 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1194526005569 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1194526005570 Putative esterase; Region: Esterase; pfam00756 1194526005571 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1194526005572 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1194526005573 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1194526005574 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1194526005575 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1194526005576 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1194526005577 NAD binding site [chemical binding]; other site 1194526005578 homotetramer interface [polypeptide binding]; other site 1194526005579 homodimer interface [polypeptide binding]; other site 1194526005580 substrate binding site [chemical binding]; other site 1194526005581 active site 1194526005582 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1194526005583 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1194526005584 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1194526005585 TrkA-N domain; Region: TrkA_N; pfam02254 1194526005586 TrkA-C domain; Region: TrkA_C; pfam02080 1194526005587 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1194526005588 MgtE intracellular N domain; Region: MgtE_N; smart00924 1194526005589 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1194526005590 Divalent cation transporter; Region: MgtE; pfam01769 1194526005591 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1194526005592 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1194526005593 active site 1194526005594 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1194526005595 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1194526005596 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1194526005597 synthetase active site [active] 1194526005598 NTP binding site [chemical binding]; other site 1194526005599 metal binding site [ion binding]; metal-binding site 1194526005600 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1194526005601 putative active site [active] 1194526005602 putative metal binding residues [ion binding]; other site 1194526005603 signature motif; other site 1194526005604 putative triphosphate binding site [ion binding]; other site 1194526005605 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1194526005606 apolar tunnel; other site 1194526005607 heme binding site [chemical binding]; other site 1194526005608 dimerization interface [polypeptide binding]; other site 1194526005609 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1194526005610 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1194526005611 catalytic residues [active] 1194526005612 oligoendopeptidase F; Region: pepF; TIGR00181 1194526005613 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1194526005614 active site 1194526005615 Zn binding site [ion binding]; other site 1194526005616 Competence protein CoiA-like family; Region: CoiA; pfam06054 1194526005617 adaptor protein; Provisional; Region: PRK02315 1194526005618 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1194526005619 ArsC family; Region: ArsC; pfam03960 1194526005620 putative catalytic residues [active] 1194526005621 thiol/disulfide switch; other site 1194526005622 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1194526005623 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1194526005624 active site 1194526005625 HIGH motif; other site 1194526005626 dimer interface [polypeptide binding]; other site 1194526005627 KMSKS motif; other site 1194526005628 potential frameshift: common BLAST hit: gi|27467602|ref|NP_764239.1| peptide binding protein OppA 1194526005629 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1194526005630 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1194526005631 Walker A/P-loop; other site 1194526005632 ATP binding site [chemical binding]; other site 1194526005633 Q-loop/lid; other site 1194526005634 ABC transporter signature motif; other site 1194526005635 Walker B; other site 1194526005636 D-loop; other site 1194526005637 H-loop/switch region; other site 1194526005638 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1194526005639 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1194526005640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1194526005641 Walker A/P-loop; other site 1194526005642 ATP binding site [chemical binding]; other site 1194526005643 Q-loop/lid; other site 1194526005644 ABC transporter signature motif; other site 1194526005645 Walker B; other site 1194526005646 D-loop; other site 1194526005647 H-loop/switch region; other site 1194526005648 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1194526005649 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1194526005650 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1194526005651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526005652 dimer interface [polypeptide binding]; other site 1194526005653 conserved gate region; other site 1194526005654 putative PBP binding loops; other site 1194526005655 ABC-ATPase subunit interface; other site 1194526005656 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1194526005657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526005658 dimer interface [polypeptide binding]; other site 1194526005659 ABC-ATPase subunit interface; other site 1194526005660 putative PBP binding loops; other site 1194526005661 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1194526005662 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1194526005663 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1194526005664 dimer interface [polypeptide binding]; other site 1194526005665 active site 1194526005666 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1194526005667 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1194526005668 dimer interface [polypeptide binding]; other site 1194526005669 active site 1194526005670 CoA binding pocket [chemical binding]; other site 1194526005671 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1194526005672 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1194526005673 Clp amino terminal domain; Region: Clp_N; pfam02861 1194526005674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526005675 Walker A motif; other site 1194526005676 ATP binding site [chemical binding]; other site 1194526005677 Walker B motif; other site 1194526005678 arginine finger; other site 1194526005679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526005680 Walker A motif; other site 1194526005681 ATP binding site [chemical binding]; other site 1194526005682 Walker B motif; other site 1194526005683 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1194526005684 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1194526005685 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1194526005686 catalytic triad [active] 1194526005687 catalytic triad [active] 1194526005688 oxyanion hole [active] 1194526005689 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1194526005690 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1194526005691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526005692 active site 1194526005693 motif I; other site 1194526005694 motif II; other site 1194526005695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526005696 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1194526005697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526005698 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1194526005699 hypothetical protein; Provisional; Region: PRK13673 1194526005700 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1194526005701 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1194526005702 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1194526005703 Part of AAA domain; Region: AAA_19; pfam13245 1194526005704 Family description; Region: UvrD_C_2; pfam13538 1194526005705 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1194526005706 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1194526005707 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1194526005708 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1194526005709 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1194526005710 Catalytic site [active] 1194526005711 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1194526005712 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1194526005713 Catalytic site [active] 1194526005714 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1194526005715 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1194526005716 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1194526005717 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1194526005718 active site 1194526005719 dimer interface [polypeptide binding]; other site 1194526005720 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1194526005721 dimer interface [polypeptide binding]; other site 1194526005722 active site 1194526005723 argininosuccinate synthase; Provisional; Region: PRK13820 1194526005724 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1194526005725 ANP binding site [chemical binding]; other site 1194526005726 Substrate Binding Site II [chemical binding]; other site 1194526005727 Substrate Binding Site I [chemical binding]; other site 1194526005728 argininosuccinate lyase; Provisional; Region: PRK00855 1194526005729 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1194526005730 active sites [active] 1194526005731 tetramer interface [polypeptide binding]; other site 1194526005732 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1194526005733 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1194526005734 active site 1194526005735 catalytic site [active] 1194526005736 metal binding site [ion binding]; metal-binding site 1194526005737 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1194526005738 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1194526005739 active site 1194526005740 catalytic site [active] 1194526005741 metal binding site [ion binding]; metal-binding site 1194526005742 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1194526005743 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1194526005744 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1194526005745 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1194526005746 NAD(P) binding site [chemical binding]; other site 1194526005747 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1194526005748 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1194526005749 inhibitor-cofactor binding pocket; inhibition site 1194526005750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526005751 catalytic residue [active] 1194526005752 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1194526005753 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1194526005754 putative active site [active] 1194526005755 putative FMN binding site [chemical binding]; other site 1194526005756 putative substrate binding site [chemical binding]; other site 1194526005757 putative catalytic residue [active] 1194526005758 general stress protein 13; Validated; Region: PRK08059 1194526005759 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1194526005760 RNA binding site [nucleotide binding]; other site 1194526005761 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1194526005762 active site 1194526005763 Kinase associated protein B; Region: KapB; pfam08810 1194526005764 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1194526005765 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1194526005766 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1194526005767 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1194526005768 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1194526005769 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1194526005770 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1194526005771 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1194526005772 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1194526005773 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1194526005774 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1194526005775 biotin synthase; Validated; Region: PRK06256 1194526005776 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1194526005777 FeS/SAM binding site; other site 1194526005778 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1194526005779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1194526005780 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1194526005781 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1194526005782 CoenzymeA binding site [chemical binding]; other site 1194526005783 subunit interaction site [polypeptide binding]; other site 1194526005784 PHB binding site; other site 1194526005785 Predicted permease [General function prediction only]; Region: COG2056 1194526005786 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1194526005787 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1194526005788 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1194526005789 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1194526005790 interface (dimer of trimers) [polypeptide binding]; other site 1194526005791 Substrate-binding/catalytic site; other site 1194526005792 Zn-binding sites [ion binding]; other site 1194526005793 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1194526005794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526005795 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1194526005796 hypothetical protein; Provisional; Region: PRK13669 1194526005797 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1194526005798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526005799 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1194526005800 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1194526005801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1194526005802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1194526005803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1194526005804 dimerization interface [polypeptide binding]; other site 1194526005805 Predicted membrane protein [Function unknown]; Region: COG2855 1194526005806 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1194526005807 DltD N-terminal region; Region: DltD_N; pfam04915 1194526005808 DltD central region; Region: DltD_M; pfam04918 1194526005809 DltD C-terminal region; Region: DltD_C; pfam04914 1194526005810 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1194526005811 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1194526005812 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1194526005813 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1194526005814 acyl-activating enzyme (AAE) consensus motif; other site 1194526005815 AMP binding site [chemical binding]; other site 1194526005816 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1194526005817 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1194526005818 dimerization interface [polypeptide binding]; other site 1194526005819 ligand binding site [chemical binding]; other site 1194526005820 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1194526005821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526005822 active site 1194526005823 motif I; other site 1194526005824 motif II; other site 1194526005825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526005826 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1194526005827 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1194526005828 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1194526005829 lipoyl synthase; Provisional; Region: PRK05481 1194526005830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1194526005831 FeS/SAM binding site; other site 1194526005832 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1194526005833 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1194526005834 active site 1194526005835 metal binding site [ion binding]; metal-binding site 1194526005836 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1194526005837 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1194526005838 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1194526005839 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1194526005840 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1194526005841 FMN binding site [chemical binding]; other site 1194526005842 substrate binding site [chemical binding]; other site 1194526005843 putative catalytic residue [active] 1194526005844 Domain of unknown function DUF21; Region: DUF21; pfam01595 1194526005845 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1194526005846 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1194526005847 FeS assembly protein SufB; Region: sufB; TIGR01980 1194526005848 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1194526005849 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1194526005850 trimerization site [polypeptide binding]; other site 1194526005851 active site 1194526005852 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1194526005853 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1194526005854 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1194526005855 catalytic residue [active] 1194526005856 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1194526005857 FeS assembly protein SufD; Region: sufD; TIGR01981 1194526005858 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1194526005859 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1194526005860 Walker A/P-loop; other site 1194526005861 ATP binding site [chemical binding]; other site 1194526005862 Q-loop/lid; other site 1194526005863 ABC transporter signature motif; other site 1194526005864 Walker B; other site 1194526005865 D-loop; other site 1194526005866 H-loop/switch region; other site 1194526005867 Predicted membrane protein [Function unknown]; Region: COG2035 1194526005868 CsbD-like; Region: CsbD; pfam05532 1194526005869 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1194526005870 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1194526005871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526005872 dimer interface [polypeptide binding]; other site 1194526005873 conserved gate region; other site 1194526005874 ABC-ATPase subunit interface; other site 1194526005875 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1194526005876 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1194526005877 Walker A/P-loop; other site 1194526005878 ATP binding site [chemical binding]; other site 1194526005879 Q-loop/lid; other site 1194526005880 ABC transporter signature motif; other site 1194526005881 Walker B; other site 1194526005882 D-loop; other site 1194526005883 H-loop/switch region; other site 1194526005884 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1194526005885 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1194526005886 catalytic residues [active] 1194526005887 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1194526005888 putative active site [active] 1194526005889 putative metal binding site [ion binding]; other site 1194526005890 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1194526005891 lipoyl attachment site [posttranslational modification]; other site 1194526005892 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1194526005893 ArsC family; Region: ArsC; pfam03960 1194526005894 putative ArsC-like catalytic residues; other site 1194526005895 putative TRX-like catalytic residues [active] 1194526005896 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1194526005897 catalytic residues [active] 1194526005898 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1194526005899 putative FMN binding site [chemical binding]; other site 1194526005900 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1194526005901 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1194526005902 active site 1194526005903 catalytic residue [active] 1194526005904 dimer interface [polypeptide binding]; other site 1194526005905 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1194526005906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1194526005907 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1194526005908 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1194526005909 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1194526005910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1194526005911 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1194526005912 catalytic core [active] 1194526005913 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1194526005914 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1194526005915 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1194526005916 DNA-binding site [nucleotide binding]; DNA binding site 1194526005917 RNA-binding motif; other site 1194526005918 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1194526005919 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1194526005920 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1194526005921 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1194526005922 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1194526005923 active site 1194526005924 catalytic tetrad [active] 1194526005925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526005926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526005927 Terminase small subunit; Region: Terminase_2; cl01513 1194526005928 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1194526005929 SmpB-tmRNA interface; other site 1194526005930 ribonuclease R; Region: RNase_R; TIGR02063 1194526005931 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1194526005932 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1194526005933 RNB domain; Region: RNB; pfam00773 1194526005934 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1194526005935 RNA binding site [nucleotide binding]; other site 1194526005936 Esterase/lipase [General function prediction only]; Region: COG1647 1194526005937 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1194526005938 enolase; Provisional; Region: eno; PRK00077 1194526005939 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1194526005940 dimer interface [polypeptide binding]; other site 1194526005941 metal binding site [ion binding]; metal-binding site 1194526005942 substrate binding pocket [chemical binding]; other site 1194526005943 phosphoglyceromutase; Provisional; Region: PRK05434 1194526005944 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1194526005945 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1194526005946 triosephosphate isomerase; Provisional; Region: PRK14567 1194526005947 substrate binding site [chemical binding]; other site 1194526005948 dimer interface [polypeptide binding]; other site 1194526005949 catalytic triad [active] 1194526005950 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1194526005951 Phosphoglycerate kinase; Region: PGK; pfam00162 1194526005952 substrate binding site [chemical binding]; other site 1194526005953 hinge regions; other site 1194526005954 ADP binding site [chemical binding]; other site 1194526005955 catalytic site [active] 1194526005956 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1194526005957 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1194526005958 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1194526005959 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1194526005960 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1194526005961 TIGR01777 family protein; Region: yfcH 1194526005962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526005963 NAD(P) binding site [chemical binding]; other site 1194526005964 active site 1194526005965 Clp protease; Region: CLP_protease; pfam00574 1194526005966 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1194526005967 oligomer interface [polypeptide binding]; other site 1194526005968 active site residues [active] 1194526005969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1194526005970 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1194526005971 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1194526005972 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1194526005973 phosphate binding site [ion binding]; other site 1194526005974 dimer interface [polypeptide binding]; other site 1194526005975 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1194526005976 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1194526005977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1194526005978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526005979 TPR repeat; Region: TPR_11; pfam13414 1194526005980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1194526005981 binding surface 1194526005982 TPR motif; other site 1194526005983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1194526005984 TPR motif; other site 1194526005985 binding surface 1194526005986 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1194526005987 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1194526005988 trimer interface [polypeptide binding]; other site 1194526005989 active site 1194526005990 substrate binding site [chemical binding]; other site 1194526005991 CoA binding site [chemical binding]; other site 1194526005992 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1194526005993 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1194526005994 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1194526005995 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1194526005996 Hpr binding site; other site 1194526005997 active site 1194526005998 homohexamer subunit interaction site [polypeptide binding]; other site 1194526005999 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1194526006000 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1194526006001 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1194526006002 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1194526006003 excinuclease ABC subunit B; Provisional; Region: PRK05298 1194526006004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1194526006005 ATP binding site [chemical binding]; other site 1194526006006 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526006007 nucleotide binding region [chemical binding]; other site 1194526006008 ATP-binding site [chemical binding]; other site 1194526006009 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1194526006010 UvrB/uvrC motif; Region: UVR; pfam02151 1194526006011 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1194526006012 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1194526006013 Zn2+ binding site [ion binding]; other site 1194526006014 Mg2+ binding site [ion binding]; other site 1194526006015 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1194526006016 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1194526006017 Surface antigen [General function prediction only]; Region: COG3942 1194526006018 CHAP domain; Region: CHAP; pfam05257 1194526006019 peptide chain release factor 2; Provisional; Region: PRK06746 1194526006020 PCRF domain; Region: PCRF; pfam03462 1194526006021 RF-1 domain; Region: RF-1; pfam00472 1194526006022 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1194526006023 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1194526006024 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1194526006025 nucleotide binding region [chemical binding]; other site 1194526006026 ATP-binding site [chemical binding]; other site 1194526006027 SEC-C motif; Region: SEC-C; pfam02810 1194526006028 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1194526006029 30S subunit binding site; other site 1194526006030 comF family protein; Region: comF; TIGR00201 1194526006031 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526006032 active site 1194526006033 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1194526006034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1194526006035 ATP binding site [chemical binding]; other site 1194526006036 putative Mg++ binding site [ion binding]; other site 1194526006037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526006038 nucleotide binding region [chemical binding]; other site 1194526006039 ATP-binding site [chemical binding]; other site 1194526006040 EDD domain protein, DegV family; Region: DegV; TIGR00762 1194526006041 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1194526006042 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1194526006043 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1194526006044 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1194526006045 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1194526006046 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1194526006047 Mg++ binding site [ion binding]; other site 1194526006048 putative catalytic motif [active] 1194526006049 substrate binding site [chemical binding]; other site 1194526006050 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1194526006051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1194526006052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1194526006053 metal binding site [ion binding]; metal-binding site 1194526006054 active site 1194526006055 I-site; other site 1194526006056 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1194526006057 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1194526006058 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1194526006059 peptidase T; Region: peptidase-T; TIGR01882 1194526006060 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1194526006061 metal binding site [ion binding]; metal-binding site 1194526006062 dimer interface [polypeptide binding]; other site 1194526006063 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1194526006064 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1194526006065 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1194526006066 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1194526006067 FAD binding domain; Region: FAD_binding_4; pfam01565 1194526006068 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1194526006069 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1194526006070 CHY zinc finger; Region: zf-CHY; pfam05495 1194526006071 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1194526006072 putative ligand binding residues [chemical binding]; other site 1194526006073 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1194526006074 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1194526006075 Walker A/P-loop; other site 1194526006076 ATP binding site [chemical binding]; other site 1194526006077 Q-loop/lid; other site 1194526006078 ABC transporter signature motif; other site 1194526006079 Walker B; other site 1194526006080 D-loop; other site 1194526006081 H-loop/switch region; other site 1194526006082 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1194526006083 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1194526006084 ABC-ATPase subunit interface; other site 1194526006085 dimer interface [polypeptide binding]; other site 1194526006086 putative PBP binding regions; other site 1194526006087 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1194526006088 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1194526006089 ABC-ATPase subunit interface; other site 1194526006090 dimer interface [polypeptide binding]; other site 1194526006091 putative PBP binding regions; other site 1194526006092 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1194526006093 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1194526006094 dimer interface [polypeptide binding]; other site 1194526006095 putative radical transfer pathway; other site 1194526006096 diiron center [ion binding]; other site 1194526006097 tyrosyl radical; other site 1194526006098 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1194526006099 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1194526006100 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1194526006101 active site 1194526006102 dimer interface [polypeptide binding]; other site 1194526006103 catalytic residues [active] 1194526006104 effector binding site; other site 1194526006105 R2 peptide binding site; other site 1194526006106 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1194526006107 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1194526006108 EamA-like transporter family; Region: EamA; pfam00892 1194526006109 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1194526006110 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1194526006111 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1194526006112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526006113 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1194526006114 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1194526006115 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1194526006116 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1194526006117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1194526006118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526006119 homodimer interface [polypeptide binding]; other site 1194526006120 catalytic residue [active] 1194526006121 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1194526006122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1194526006123 dimer interface [polypeptide binding]; other site 1194526006124 conserved gate region; other site 1194526006125 ABC-ATPase subunit interface; other site 1194526006126 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1194526006127 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1194526006128 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1194526006129 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1194526006130 Walker A/P-loop; other site 1194526006131 ATP binding site [chemical binding]; other site 1194526006132 Q-loop/lid; other site 1194526006133 ABC transporter signature motif; other site 1194526006134 Walker B; other site 1194526006135 D-loop; other site 1194526006136 H-loop/switch region; other site 1194526006137 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1194526006138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1194526006139 ATP binding site [chemical binding]; other site 1194526006140 putative Mg++ binding site [ion binding]; other site 1194526006141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526006142 nucleotide binding region [chemical binding]; other site 1194526006143 ATP-binding site [chemical binding]; other site 1194526006144 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1194526006145 HRDC domain; Region: HRDC; pfam00570 1194526006146 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1194526006147 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1194526006148 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1194526006149 ABC transporter; Region: ABC_tran_2; pfam12848 1194526006150 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1194526006151 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1194526006152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1194526006153 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1194526006154 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1194526006155 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1194526006156 Cation transport protein; Region: TrkH; cl17365 1194526006157 Sulfatase; Region: Sulfatase; pfam00884 1194526006158 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1194526006159 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1194526006160 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1194526006161 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1194526006162 substrate-cofactor binding pocket; other site 1194526006163 homodimer interface [polypeptide binding]; other site 1194526006164 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1194526006165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526006166 catalytic residue [active] 1194526006167 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1194526006168 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1194526006169 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1194526006170 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1194526006171 glutamine binding [chemical binding]; other site 1194526006172 catalytic triad [active] 1194526006173 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1194526006174 Ligand Binding Site [chemical binding]; other site 1194526006175 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1194526006176 active site 1194526006177 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1194526006178 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1194526006179 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1194526006180 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1194526006181 Ligand binding site; other site 1194526006182 Putative Catalytic site; other site 1194526006183 DXD motif; other site 1194526006184 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1194526006185 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1194526006186 active site 1194526006187 catalytic tetrad [active] 1194526006188 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1194526006189 Domain of unknown function DUF21; Region: DUF21; pfam01595 1194526006190 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1194526006191 Transporter associated domain; Region: CorC_HlyC; smart01091 1194526006192 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1194526006193 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1194526006194 active site 1194526006195 dimer interface [polypeptide binding]; other site 1194526006196 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1194526006197 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1194526006198 active site 1194526006199 phosphorylation site [posttranslational modification] 1194526006200 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1194526006201 active site 1194526006202 P-loop; other site 1194526006203 phosphorylation site [posttranslational modification] 1194526006204 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1194526006205 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1194526006206 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1194526006207 putative substrate binding site [chemical binding]; other site 1194526006208 putative ATP binding site [chemical binding]; other site 1194526006209 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1194526006210 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1194526006211 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1194526006212 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1194526006213 putative deacylase active site [active] 1194526006214 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1194526006215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526006216 putative substrate translocation pore; other site 1194526006217 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1194526006218 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1194526006219 DNA photolyase; Region: DNA_photolyase; pfam00875 1194526006220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1194526006221 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1194526006222 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1194526006223 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1194526006224 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1194526006225 transmembrane helices; other site 1194526006226 malate dehydrogenase; Reviewed; Region: PRK06223 1194526006227 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1194526006228 NAD(P) binding site [chemical binding]; other site 1194526006229 dimer interface [polypeptide binding]; other site 1194526006230 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1194526006231 substrate binding site [chemical binding]; other site 1194526006232 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1194526006233 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1194526006234 active site 1194526006235 catalytic tetrad [active] 1194526006236 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1194526006237 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1194526006238 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1194526006239 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1194526006240 MarR family; Region: MarR; pfam01047 1194526006241 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1194526006242 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1194526006243 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1194526006244 Walker A/P-loop; other site 1194526006245 ATP binding site [chemical binding]; other site 1194526006246 Q-loop/lid; other site 1194526006247 ABC transporter signature motif; other site 1194526006248 Walker B; other site 1194526006249 D-loop; other site 1194526006250 H-loop/switch region; other site 1194526006251 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1194526006252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1194526006253 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1194526006254 Walker A/P-loop; other site 1194526006255 ATP binding site [chemical binding]; other site 1194526006256 Q-loop/lid; other site 1194526006257 ABC transporter signature motif; other site 1194526006258 Walker B; other site 1194526006259 D-loop; other site 1194526006260 H-loop/switch region; other site 1194526006261 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1194526006262 hypothetical protein; Validated; Region: PRK00124 1194526006263 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1194526006264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1194526006265 Rrf2 family protein; Region: rrf2_super; TIGR00738 1194526006266 Transcriptional regulator; Region: Rrf2; pfam02082 1194526006267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526006268 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1194526006269 NAD(P) binding site [chemical binding]; other site 1194526006270 active site 1194526006271 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1194526006272 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1194526006273 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 1194526006274 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 1194526006275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526006276 Coenzyme A binding pocket [chemical binding]; other site 1194526006277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1194526006278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526006279 sugar efflux transporter; Region: 2A0120; TIGR00899 1194526006280 putative substrate translocation pore; other site 1194526006281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1194526006282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1194526006283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1194526006284 dimerization interface [polypeptide binding]; other site 1194526006285 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1194526006286 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1194526006287 hypothetical protein; Provisional; Region: PRK12378 1194526006288 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1194526006289 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1194526006290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1194526006291 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1194526006292 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1194526006293 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1194526006294 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1194526006295 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1194526006296 Surface antigen [General function prediction only]; Region: COG3942 1194526006297 CHAP domain; Region: CHAP; pfam05257 1194526006298 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1194526006299 Patatin-like phospholipase; Region: Patatin; pfam01734 1194526006300 active site 1194526006301 nucleophile elbow; other site 1194526006302 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1194526006303 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1194526006304 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1194526006305 FtsX-like permease family; Region: FtsX; pfam02687 1194526006306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1194526006307 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1194526006308 Walker A/P-loop; other site 1194526006309 ATP binding site [chemical binding]; other site 1194526006310 Q-loop/lid; other site 1194526006311 ABC transporter signature motif; other site 1194526006312 Walker B; other site 1194526006313 D-loop; other site 1194526006314 H-loop/switch region; other site 1194526006315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1194526006316 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1194526006317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1194526006318 ATP binding site [chemical binding]; other site 1194526006319 Mg2+ binding site [ion binding]; other site 1194526006320 G-X-G motif; other site 1194526006321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1194526006322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1194526006323 active site 1194526006324 phosphorylation site [posttranslational modification] 1194526006325 intermolecular recognition site; other site 1194526006326 dimerization interface [polypeptide binding]; other site 1194526006327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1194526006328 DNA binding site [nucleotide binding] 1194526006329 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1194526006330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526006331 NAD(P) binding site [chemical binding]; other site 1194526006332 active site 1194526006333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1194526006334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526006335 Coenzyme A binding pocket [chemical binding]; other site 1194526006336 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1194526006337 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1194526006338 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1194526006339 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1194526006340 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1194526006341 Na binding site [ion binding]; other site 1194526006342 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1194526006343 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1194526006344 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1194526006345 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1194526006346 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1194526006347 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1194526006348 ABC-ATPase subunit interface; other site 1194526006349 dimer interface [polypeptide binding]; other site 1194526006350 putative PBP binding regions; other site 1194526006351 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1194526006352 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1194526006353 ABC-ATPase subunit interface; other site 1194526006354 dimer interface [polypeptide binding]; other site 1194526006355 putative PBP binding regions; other site 1194526006356 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1194526006357 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1194526006358 Walker A/P-loop; other site 1194526006359 ATP binding site [chemical binding]; other site 1194526006360 Q-loop/lid; other site 1194526006361 ABC transporter signature motif; other site 1194526006362 Walker B; other site 1194526006363 D-loop; other site 1194526006364 H-loop/switch region; other site 1194526006365 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1194526006366 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1194526006367 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1194526006368 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1194526006369 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1194526006370 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1194526006371 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1194526006372 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1194526006373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526006374 Walker A/P-loop; other site 1194526006375 ATP binding site [chemical binding]; other site 1194526006376 Q-loop/lid; other site 1194526006377 ABC transporter signature motif; other site 1194526006378 Walker B; other site 1194526006379 D-loop; other site 1194526006380 H-loop/switch region; other site 1194526006381 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1194526006382 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1194526006383 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1194526006384 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1194526006385 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1194526006386 active site 1194526006387 nucleotide binding site [chemical binding]; other site 1194526006388 HIGH motif; other site 1194526006389 KMSKS motif; other site 1194526006390 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1194526006391 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1194526006392 active site 1194526006393 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1194526006394 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1194526006395 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1194526006396 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1194526006397 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1194526006398 Walker A/P-loop; other site 1194526006399 ATP binding site [chemical binding]; other site 1194526006400 Q-loop/lid; other site 1194526006401 ABC transporter signature motif; other site 1194526006402 Walker B; other site 1194526006403 D-loop; other site 1194526006404 H-loop/switch region; other site 1194526006405 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1194526006406 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1194526006407 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1194526006408 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1194526006409 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1194526006410 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1194526006411 FeoA domain; Region: FeoA; pfam04023 1194526006412 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1194526006413 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1194526006414 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1194526006415 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1194526006416 ABC-ATPase subunit interface; other site 1194526006417 dimer interface [polypeptide binding]; other site 1194526006418 putative PBP binding regions; other site 1194526006419 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1194526006420 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1194526006421 intersubunit interface [polypeptide binding]; other site 1194526006422 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1194526006423 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1194526006424 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1194526006425 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1194526006426 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1194526006427 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1194526006428 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1194526006429 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1194526006430 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1194526006431 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1194526006432 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1194526006433 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1194526006434 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1194526006435 active site 1194526006436 DNA binding site [nucleotide binding] 1194526006437 Int/Topo IB signature motif; other site 1194526006438 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1194526006439 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1194526006440 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1194526006441 HlyD family secretion protein; Region: HlyD_3; pfam13437 1194526006442 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1194526006443 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1194526006444 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1194526006445 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1194526006446 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1194526006447 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1194526006448 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1194526006449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526006450 motif II; other site 1194526006451 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1194526006452 ABC-ATPase subunit interface; other site 1194526006453 dimer interface [polypeptide binding]; other site 1194526006454 putative PBP binding regions; other site 1194526006455 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1194526006456 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1194526006457 putative binding site residues; other site 1194526006458 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1194526006459 putative efflux protein, MATE family; Region: matE; TIGR00797 1194526006460 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1194526006461 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1194526006462 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1194526006463 minor groove reading motif; other site 1194526006464 helix-hairpin-helix signature motif; other site 1194526006465 substrate binding pocket [chemical binding]; other site 1194526006466 active site 1194526006467 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1194526006468 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1194526006469 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1194526006470 active site 1194526006471 HIGH motif; other site 1194526006472 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1194526006473 KMSK motif region; other site 1194526006474 tRNA binding surface [nucleotide binding]; other site 1194526006475 DALR anticodon binding domain; Region: DALR_1; smart00836 1194526006476 anticodon binding site; other site 1194526006477 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1194526006478 YwhD family; Region: YwhD; pfam08741 1194526006479 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1194526006480 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1194526006481 Zn2+ binding site [ion binding]; other site 1194526006482 Mg2+ binding site [ion binding]; other site 1194526006483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1194526006484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526006485 Coenzyme A binding pocket [chemical binding]; other site 1194526006486 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1194526006487 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1194526006488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1194526006489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1194526006490 active site 1194526006491 catalytic tetrad [active] 1194526006492 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1194526006493 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1194526006494 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1194526006495 diphosphomevalonate decarboxylase; Region: PLN02407 1194526006496 mevalonate kinase; Region: mevalon_kin; TIGR00549 1194526006497 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1194526006498 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1194526006499 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1194526006500 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1194526006501 putative heme peroxidase; Provisional; Region: PRK12276 1194526006502 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1194526006503 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1194526006504 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1194526006505 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1194526006506 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1194526006507 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1194526006508 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1194526006509 ligand binding site [chemical binding]; other site 1194526006510 active site 1194526006511 UGI interface [polypeptide binding]; other site 1194526006512 catalytic site [active] 1194526006513 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1194526006514 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1194526006515 active site 1194526006516 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1194526006517 dimer interface [polypeptide binding]; other site 1194526006518 substrate binding site [chemical binding]; other site 1194526006519 ATP binding site [chemical binding]; other site 1194526006520 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1194526006521 Staphostatin A; Region: Staphostatin_A; pfam09022 1194526006522 proline/glycine betaine transporter; Provisional; Region: PRK10642 1194526006523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526006524 putative substrate translocation pore; other site 1194526006525 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1194526006526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526006527 motif II; other site 1194526006528 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1194526006529 tetramer interface [polypeptide binding]; other site 1194526006530 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1194526006531 active site 1194526006532 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1194526006533 active site 1194526006534 dimer interface [polypeptide binding]; other site 1194526006535 magnesium binding site [ion binding]; other site 1194526006536 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1194526006537 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1194526006538 active site 1194526006539 trimer interface [polypeptide binding]; other site 1194526006540 allosteric site; other site 1194526006541 active site lid [active] 1194526006542 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1194526006543 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1194526006544 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1194526006545 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1194526006546 D-galactonate transporter; Region: 2A0114; TIGR00893 1194526006547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526006548 putative substrate translocation pore; other site 1194526006549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526006550 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1194526006551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1194526006552 active site 1194526006553 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1194526006554 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1194526006555 Cna protein B-type domain; Region: Cna_B; pfam05738 1194526006556 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1194526006557 Predicted flavoprotein [General function prediction only]; Region: COG0431 1194526006558 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1194526006559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526006560 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1194526006561 active site 1194526006562 motif I; other site 1194526006563 motif II; other site 1194526006564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526006565 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1194526006566 nucleoside/Zn binding site; other site 1194526006567 dimer interface [polypeptide binding]; other site 1194526006568 catalytic motif [active] 1194526006569 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1194526006570 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1194526006571 Substrate-binding site [chemical binding]; other site 1194526006572 Substrate specificity [chemical binding]; other site 1194526006573 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1194526006574 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1194526006575 Substrate-binding site [chemical binding]; other site 1194526006576 Substrate specificity [chemical binding]; other site 1194526006577 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1194526006578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526006579 motif II; other site 1194526006580 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1194526006581 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1194526006582 homodimer interface [polypeptide binding]; other site 1194526006583 substrate-cofactor binding pocket; other site 1194526006584 catalytic residue [active] 1194526006585 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1194526006586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526006587 NAD(P) binding site [chemical binding]; other site 1194526006588 active site 1194526006589 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1194526006590 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1194526006591 active site 1194526006592 metal binding site [ion binding]; metal-binding site 1194526006593 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1194526006594 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1194526006595 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1194526006596 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1194526006597 NADP binding site [chemical binding]; other site 1194526006598 ribulokinase; Provisional; Region: PRK04123 1194526006599 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1194526006600 N- and C-terminal domain interface [polypeptide binding]; other site 1194526006601 active site 1194526006602 MgATP binding site [chemical binding]; other site 1194526006603 catalytic site [active] 1194526006604 metal binding site [ion binding]; metal-binding site 1194526006605 carbohydrate binding site [chemical binding]; other site 1194526006606 homodimer interface [polypeptide binding]; other site 1194526006607 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1194526006608 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1194526006609 NAD(P) binding site [chemical binding]; other site 1194526006610 polyol permease family; Region: 2A0118; TIGR00897 1194526006611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526006612 putative substrate translocation pore; other site 1194526006613 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1194526006614 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1194526006615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1194526006616 ornithine cyclodeaminase; Validated; Region: PRK08618 1194526006617 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1194526006618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1194526006619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526006620 Coenzyme A binding pocket [chemical binding]; other site 1194526006621 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1194526006622 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1194526006623 substrate-cofactor binding pocket; other site 1194526006624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526006625 catalytic residue [active] 1194526006626 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1194526006627 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1194526006628 metal binding site [ion binding]; metal-binding site 1194526006629 dimer interface [polypeptide binding]; other site 1194526006630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1194526006631 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1194526006632 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1194526006633 elongation factor Tu; Reviewed; Region: PRK00049 1194526006634 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1194526006635 G1 box; other site 1194526006636 GEF interaction site [polypeptide binding]; other site 1194526006637 GTP/Mg2+ binding site [chemical binding]; other site 1194526006638 Switch I region; other site 1194526006639 G2 box; other site 1194526006640 G3 box; other site 1194526006641 Switch II region; other site 1194526006642 G4 box; other site 1194526006643 G5 box; other site 1194526006644 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1194526006645 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1194526006646 Antibiotic Binding Site [chemical binding]; other site 1194526006647 elongation factor G; Reviewed; Region: PRK00007 1194526006648 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1194526006649 G1 box; other site 1194526006650 putative GEF interaction site [polypeptide binding]; other site 1194526006651 GTP/Mg2+ binding site [chemical binding]; other site 1194526006652 Switch I region; other site 1194526006653 G2 box; other site 1194526006654 G3 box; other site 1194526006655 Switch II region; other site 1194526006656 G4 box; other site 1194526006657 G5 box; other site 1194526006658 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1194526006659 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1194526006660 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1194526006661 30S ribosomal protein S7; Validated; Region: PRK05302 1194526006662 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1194526006663 S17 interaction site [polypeptide binding]; other site 1194526006664 S8 interaction site; other site 1194526006665 16S rRNA interaction site [nucleotide binding]; other site 1194526006666 streptomycin interaction site [chemical binding]; other site 1194526006667 23S rRNA interaction site [nucleotide binding]; other site 1194526006668 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1194526006669 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1194526006670 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1194526006671 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1194526006672 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1194526006673 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1194526006674 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1194526006675 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1194526006676 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1194526006677 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1194526006678 G-loop; other site 1194526006679 DNA binding site [nucleotide binding] 1194526006680 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1194526006681 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1194526006682 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1194526006683 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1194526006684 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1194526006685 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1194526006686 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1194526006687 RPB10 interaction site [polypeptide binding]; other site 1194526006688 RPB1 interaction site [polypeptide binding]; other site 1194526006689 RPB11 interaction site [polypeptide binding]; other site 1194526006690 RPB3 interaction site [polypeptide binding]; other site 1194526006691 RPB12 interaction site [polypeptide binding]; other site 1194526006692 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1194526006693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526006694 S-adenosylmethionine binding site [chemical binding]; other site 1194526006695 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1194526006696 peripheral dimer interface [polypeptide binding]; other site 1194526006697 core dimer interface [polypeptide binding]; other site 1194526006698 L10 interface [polypeptide binding]; other site 1194526006699 L11 interface [polypeptide binding]; other site 1194526006700 putative EF-Tu interaction site [polypeptide binding]; other site 1194526006701 putative EF-G interaction site [polypeptide binding]; other site 1194526006702 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1194526006703 23S rRNA interface [nucleotide binding]; other site 1194526006704 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1194526006705 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1194526006706 mRNA/rRNA interface [nucleotide binding]; other site 1194526006707 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1194526006708 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1194526006709 23S rRNA interface [nucleotide binding]; other site 1194526006710 L7/L12 interface [polypeptide binding]; other site 1194526006711 putative thiostrepton binding site; other site 1194526006712 L25 interface [polypeptide binding]; other site 1194526006713 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1194526006714 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1194526006715 putative homodimer interface [polypeptide binding]; other site 1194526006716 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1194526006717 heterodimer interface [polypeptide binding]; other site 1194526006718 homodimer interface [polypeptide binding]; other site 1194526006719 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1194526006720 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1194526006721 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1194526006722 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1194526006723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1194526006724 DNA binding residues [nucleotide binding] 1194526006725 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1194526006726 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1194526006727 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1194526006728 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1194526006729 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1194526006730 active site 1194526006731 metal binding site [ion binding]; metal-binding site 1194526006732 dimerization interface [polypeptide binding]; other site 1194526006733 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1194526006734 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1194526006735 active site 1194526006736 HIGH motif; other site 1194526006737 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1194526006738 KMSKS motif; other site 1194526006739 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1194526006740 tRNA binding surface [nucleotide binding]; other site 1194526006741 anticodon binding site; other site 1194526006742 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1194526006743 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1194526006744 trimer interface [polypeptide binding]; other site 1194526006745 active site 1194526006746 substrate binding site [chemical binding]; other site 1194526006747 CoA binding site [chemical binding]; other site 1194526006748 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1194526006749 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1194526006750 active site 1194526006751 HIGH motif; other site 1194526006752 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1194526006753 active site 1194526006754 KMSKS motif; other site 1194526006755 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1194526006756 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1194526006757 putative active site [active] 1194526006758 DNA repair protein RadA; Provisional; Region: PRK11823 1194526006759 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1194526006760 Walker A motif/ATP binding site; other site 1194526006761 ATP binding site [chemical binding]; other site 1194526006762 Walker B motif; other site 1194526006763 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1194526006764 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1194526006765 Clp amino terminal domain; Region: Clp_N; pfam02861 1194526006766 Clp amino terminal domain; Region: Clp_N; pfam02861 1194526006767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526006768 Walker A motif; other site 1194526006769 ATP binding site [chemical binding]; other site 1194526006770 Walker B motif; other site 1194526006771 arginine finger; other site 1194526006772 UvrB/uvrC motif; Region: UVR; pfam02151 1194526006773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526006774 Walker A motif; other site 1194526006775 ATP binding site [chemical binding]; other site 1194526006776 Walker B motif; other site 1194526006777 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1194526006778 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1194526006779 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1194526006780 ADP binding site [chemical binding]; other site 1194526006781 phosphagen binding site; other site 1194526006782 substrate specificity loop; other site 1194526006783 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1194526006784 UvrB/uvrC motif; Region: UVR; pfam02151 1194526006785 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1194526006786 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1194526006787 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1194526006788 Nucleoside recognition; Region: Gate; pfam07670 1194526006789 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1194526006790 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1194526006791 predicted active site [active] 1194526006792 catalytic triad [active] 1194526006793 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1194526006794 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1194526006795 active site 1194526006796 multimer interface [polypeptide binding]; other site 1194526006797 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1194526006798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1194526006799 DNA-binding site [nucleotide binding]; DNA binding site 1194526006800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1194526006801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526006802 homodimer interface [polypeptide binding]; other site 1194526006803 catalytic residue [active] 1194526006804 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1194526006805 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1194526006806 dimer interface [polypeptide binding]; other site 1194526006807 putative anticodon binding site; other site 1194526006808 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1194526006809 motif 1; other site 1194526006810 active site 1194526006811 motif 2; other site 1194526006812 motif 3; other site 1194526006813 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1194526006814 catalytic center binding site [active] 1194526006815 ATP binding site [chemical binding]; other site 1194526006816 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1194526006817 homooctamer interface [polypeptide binding]; other site 1194526006818 active site 1194526006819 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1194526006820 dihydropteroate synthase; Region: DHPS; TIGR01496 1194526006821 substrate binding pocket [chemical binding]; other site 1194526006822 dimer interface [polypeptide binding]; other site 1194526006823 inhibitor binding site; inhibition site 1194526006824 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1194526006825 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1194526006826 dimer interface [polypeptide binding]; other site 1194526006827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526006828 catalytic residue [active] 1194526006829 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1194526006830 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1194526006831 dimerization interface [polypeptide binding]; other site 1194526006832 domain crossover interface; other site 1194526006833 redox-dependent activation switch; other site 1194526006834 FtsH Extracellular; Region: FtsH_ext; pfam06480 1194526006835 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1194526006836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526006837 Walker A motif; other site 1194526006838 ATP binding site [chemical binding]; other site 1194526006839 Walker B motif; other site 1194526006840 arginine finger; other site 1194526006841 Peptidase family M41; Region: Peptidase_M41; pfam01434 1194526006842 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1194526006843 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526006844 active site 1194526006845 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1194526006846 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1194526006847 Ligand Binding Site [chemical binding]; other site 1194526006848 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1194526006849 hypothetical protein; Provisional; Region: PRK08582 1194526006850 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1194526006851 RNA binding site [nucleotide binding]; other site 1194526006852 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1194526006853 Septum formation initiator; Region: DivIC; pfam04977 1194526006854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1194526006855 RNA binding surface [nucleotide binding]; other site 1194526006856 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1194526006857 putative SAM binding site [chemical binding]; other site 1194526006858 putative homodimer interface [polypeptide binding]; other site 1194526006859 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1194526006860 homodimer interface [polypeptide binding]; other site 1194526006861 metal binding site [ion binding]; metal-binding site 1194526006862 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1194526006863 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1194526006864 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1194526006865 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1194526006866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1194526006867 ATP binding site [chemical binding]; other site 1194526006868 putative Mg++ binding site [ion binding]; other site 1194526006869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1194526006870 nucleotide binding region [chemical binding]; other site 1194526006871 ATP-binding site [chemical binding]; other site 1194526006872 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1194526006873 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1194526006874 putative active site [active] 1194526006875 catalytic residue [active] 1194526006876 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1194526006877 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1194526006878 5S rRNA interface [nucleotide binding]; other site 1194526006879 CTC domain interface [polypeptide binding]; other site 1194526006880 L16 interface [polypeptide binding]; other site 1194526006881 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1194526006882 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1194526006883 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526006884 active site 1194526006885 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1194526006886 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1194526006887 Substrate binding site; other site 1194526006888 Mg++ binding site; other site 1194526006889 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1194526006890 active site 1194526006891 substrate binding site [chemical binding]; other site 1194526006892 CoA binding site [chemical binding]; other site 1194526006893 regulatory protein SpoVG; Reviewed; Region: PRK13259 1194526006894 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1194526006895 homotrimer interaction site [polypeptide binding]; other site 1194526006896 putative active site [active] 1194526006897 pur operon repressor; Provisional; Region: PRK09213 1194526006898 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1194526006899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526006900 active site 1194526006901 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1194526006902 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1194526006903 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1194526006904 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1194526006905 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1194526006906 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1194526006907 S-adenosylmethionine binding site [chemical binding]; other site 1194526006908 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1194526006909 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1194526006910 putative active site [active] 1194526006911 putative metal binding site [ion binding]; other site 1194526006912 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1194526006913 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1194526006914 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1194526006915 active site 1194526006916 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1194526006917 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1194526006918 active site 1194526006919 HIGH motif; other site 1194526006920 KMSKS motif; other site 1194526006921 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1194526006922 tRNA binding surface [nucleotide binding]; other site 1194526006923 anticodon binding site; other site 1194526006924 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1194526006925 putative tRNA-binding site [nucleotide binding]; other site 1194526006926 dimer interface [polypeptide binding]; other site 1194526006927 Predicted methyltransferases [General function prediction only]; Region: COG0313 1194526006928 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1194526006929 putative SAM binding site [chemical binding]; other site 1194526006930 putative homodimer interface [polypeptide binding]; other site 1194526006931 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1194526006932 GIY-YIG motif/motif A; other site 1194526006933 putative active site [active] 1194526006934 putative metal binding site [ion binding]; other site 1194526006935 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1194526006936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526006937 S-adenosylmethionine binding site [chemical binding]; other site 1194526006938 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1194526006939 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1194526006940 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1194526006941 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1194526006942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1194526006943 thymidylate kinase; Validated; Region: tmk; PRK00698 1194526006944 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1194526006945 TMP-binding site; other site 1194526006946 ATP-binding site [chemical binding]; other site 1194526006947 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1194526006948 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1194526006949 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1194526006950 catalytic residue [active] 1194526006951 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1194526006952 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1194526006953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526006954 Coenzyme A binding pocket [chemical binding]; other site 1194526006955 recombination protein RecR; Reviewed; Region: recR; PRK00076 1194526006956 RecR protein; Region: RecR; pfam02132 1194526006957 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1194526006958 putative active site [active] 1194526006959 putative metal-binding site [ion binding]; other site 1194526006960 tetramer interface [polypeptide binding]; other site 1194526006961 hypothetical protein; Validated; Region: PRK00153 1194526006962 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1194526006963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1194526006964 Walker A motif; other site 1194526006965 ATP binding site [chemical binding]; other site 1194526006966 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1194526006967 Walker B motif; other site 1194526006968 arginine finger; other site 1194526006969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1194526006970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526006971 Coenzyme A binding pocket [chemical binding]; other site 1194526006972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1194526006973 DNA-binding site [nucleotide binding]; DNA binding site 1194526006974 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1194526006975 UTRA domain; Region: UTRA; pfam07702 1194526006976 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1194526006977 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1194526006978 Ca binding site [ion binding]; other site 1194526006979 active site 1194526006980 catalytic site [active] 1194526006981 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1194526006982 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1194526006983 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1194526006984 active site turn [active] 1194526006985 phosphorylation site [posttranslational modification] 1194526006986 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1194526006987 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1194526006988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1194526006989 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1194526006990 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1194526006991 active site 1194526006992 dimer interface [polypeptide binding]; other site 1194526006993 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1194526006994 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1194526006995 active site 1194526006996 FMN binding site [chemical binding]; other site 1194526006997 substrate binding site [chemical binding]; other site 1194526006998 3Fe-4S cluster binding site [ion binding]; other site 1194526006999 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1194526007000 domain interface; other site 1194526007001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1194526007002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1194526007003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1194526007004 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1194526007005 YibE/F-like protein; Region: YibE_F; cl02259 1194526007006 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1194526007007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526007008 Coenzyme A binding pocket [chemical binding]; other site 1194526007009 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1194526007010 nudix motif; other site 1194526007011 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1194526007012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1194526007013 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1194526007014 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1194526007015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526007016 NAD(P) binding site [chemical binding]; other site 1194526007017 active site 1194526007018 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1194526007019 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1194526007020 Surface antigen [General function prediction only]; Region: COG3942 1194526007021 CHAP domain; Region: CHAP; pfam05257 1194526007022 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1194526007023 DNA-binding site [nucleotide binding]; DNA binding site 1194526007024 RNA-binding motif; other site 1194526007025 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1194526007026 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1194526007027 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1194526007028 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1194526007029 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1194526007030 NAD binding site [chemical binding]; other site 1194526007031 Phe binding site; other site 1194526007032 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1194526007033 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1194526007034 active site 1194526007035 metal binding site [ion binding]; metal-binding site 1194526007036 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1194526007037 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1194526007038 putative DNA binding site [nucleotide binding]; other site 1194526007039 putative Zn2+ binding site [ion binding]; other site 1194526007040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1194526007041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1194526007042 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1194526007043 cystathionine beta-lyase; Provisional; Region: PRK07671 1194526007044 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1194526007045 homodimer interface [polypeptide binding]; other site 1194526007046 substrate-cofactor binding pocket; other site 1194526007047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526007048 catalytic residue [active] 1194526007049 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1194526007050 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1194526007051 dimer interface [polypeptide binding]; other site 1194526007052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526007053 catalytic residue [active] 1194526007054 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1194526007055 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1194526007056 chaperone protein HchA; Provisional; Region: PRK04155 1194526007057 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1194526007058 conserved cys residue [active] 1194526007059 Lysine efflux permease [General function prediction only]; Region: COG1279 1194526007060 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1194526007061 Na2 binding site [ion binding]; other site 1194526007062 putative substrate binding site 1 [chemical binding]; other site 1194526007063 Na binding site 1 [ion binding]; other site 1194526007064 putative substrate binding site 2 [chemical binding]; other site 1194526007065 Esterase/lipase [General function prediction only]; Region: COG1647 1194526007066 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1194526007067 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1194526007068 active site 1194526007069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1194526007070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1194526007071 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1194526007072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1194526007073 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1194526007074 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1194526007075 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1194526007076 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1194526007077 Cadmium resistance transporter; Region: Cad; pfam03596 1194526007078 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1194526007079 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1194526007080 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1194526007081 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1194526007082 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1194526007083 active site 1194526007084 nucleophile elbow; other site 1194526007085 GMP synthase; Reviewed; Region: guaA; PRK00074 1194526007086 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1194526007087 AMP/PPi binding site [chemical binding]; other site 1194526007088 candidate oxyanion hole; other site 1194526007089 catalytic triad [active] 1194526007090 potential glutamine specificity residues [chemical binding]; other site 1194526007091 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1194526007092 ATP Binding subdomain [chemical binding]; other site 1194526007093 Ligand Binding sites [chemical binding]; other site 1194526007094 Dimerization subdomain; other site 1194526007095 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1194526007096 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1194526007097 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1194526007098 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1194526007099 active site 1194526007100 xanthine permease; Region: pbuX; TIGR03173 1194526007101 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1194526007102 active site 1194526007103 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1194526007104 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1194526007105 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1194526007106 putative ADP-binding pocket [chemical binding]; other site 1194526007107 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1194526007108 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1194526007109 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1194526007110 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1194526007111 dimer interface [polypeptide binding]; other site 1194526007112 FMN binding site [chemical binding]; other site 1194526007113 NADPH bind site [chemical binding]; other site 1194526007114 peroxiredoxin; Region: AhpC; TIGR03137 1194526007115 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1194526007116 dimer interface [polypeptide binding]; other site 1194526007117 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1194526007118 catalytic triad [active] 1194526007119 peroxidatic and resolving cysteines [active] 1194526007120 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1194526007121 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1194526007122 catalytic residue [active] 1194526007123 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1194526007124 catalytic residues [active] 1194526007125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1194526007126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1194526007127 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1194526007128 catalytic core [active] 1194526007129 LysE type translocator; Region: LysE; cl00565 1194526007130 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1194526007131 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1194526007132 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1194526007133 active site 1194526007134 Terminase small subunit; Region: Terminase_2; pfam03592 1194526007135 Coat F domain; Region: Coat_F; cl17715 1194526007136 glyceraldehyde-3-phosphate dehydrogenase, type II; Region: GAPDH-II_archae; TIGR01546 1194526007137 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1194526007138 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1194526007139 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 1194526007140 Helix-turn-helix domain; Region: HTH_31; pfam13560 1194526007141 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1194526007142 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1194526007143 Int/Topo IB signature motif; other site 1194526007144 KilA-N domain; Region: KilA-N; pfam04383 1194526007145 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1194526007146 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1194526007147 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1194526007148 dimer interface [polypeptide binding]; other site 1194526007149 ssDNA binding site [nucleotide binding]; other site 1194526007150 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1194526007151 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1194526007152 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1194526007153 active site 1194526007154 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1194526007155 GTP-binding protein YchF; Reviewed; Region: PRK09601 1194526007156 YchF GTPase; Region: YchF; cd01900 1194526007157 G1 box; other site 1194526007158 GTP/Mg2+ binding site [chemical binding]; other site 1194526007159 Switch I region; other site 1194526007160 G2 box; other site 1194526007161 Switch II region; other site 1194526007162 G3 box; other site 1194526007163 G4 box; other site 1194526007164 G5 box; other site 1194526007165 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1194526007166 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1194526007167 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1194526007168 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1194526007169 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1194526007170 ParB-like nuclease domain; Region: ParB; smart00470 1194526007171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1194526007172 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1194526007173 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1194526007174 homodimer interface [polypeptide binding]; other site 1194526007175 substrate-cofactor binding pocket; other site 1194526007176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526007177 catalytic residue [active] 1194526007178 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1194526007179 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1194526007180 homodimer interface [polypeptide binding]; other site 1194526007181 substrate-cofactor binding pocket; other site 1194526007182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1194526007183 catalytic residue [active] 1194526007184 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1194526007185 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1194526007186 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1194526007187 FAD binding site [chemical binding]; other site 1194526007188 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1194526007189 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1194526007190 THF binding site; other site 1194526007191 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1194526007192 substrate binding site [chemical binding]; other site 1194526007193 THF binding site; other site 1194526007194 zinc-binding site [ion binding]; other site 1194526007195 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1194526007196 CHAP domain; Region: CHAP; pfam05257 1194526007197 Surface antigen [General function prediction only]; Region: COG3942 1194526007198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1194526007199 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1194526007200 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1194526007201 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1194526007202 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1194526007203 putative acyltransferase; Provisional; Region: PRK05790 1194526007204 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1194526007205 dimer interface [polypeptide binding]; other site 1194526007206 active site 1194526007207 beta-D-glucuronidase; Provisional; Region: PRK10150 1194526007208 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1194526007209 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1194526007210 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1194526007211 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1194526007212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526007213 NAD(P) binding site [chemical binding]; other site 1194526007214 active site 1194526007215 mannonate dehydratase; Provisional; Region: PRK03906 1194526007216 mannonate dehydratase; Region: uxuA; TIGR00695 1194526007217 glucuronate isomerase; Reviewed; Region: PRK02925 1194526007218 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1194526007219 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1194526007220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1194526007221 putative substrate translocation pore; other site 1194526007222 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1194526007223 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1194526007224 substrate binding site [chemical binding]; other site 1194526007225 ATP binding site [chemical binding]; other site 1194526007226 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1194526007227 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1194526007228 active site 1194526007229 intersubunit interface [polypeptide binding]; other site 1194526007230 catalytic residue [active] 1194526007231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1194526007232 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1194526007233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1194526007234 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1194526007235 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1194526007236 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1194526007237 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1194526007238 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1194526007239 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1194526007240 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1194526007241 Nucleoside recognition; Region: Gate; pfam07670 1194526007242 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1194526007243 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1194526007244 MepB protein; Region: MepB; pfam08877 1194526007245 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1194526007246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1194526007247 non-specific DNA binding site [nucleotide binding]; other site 1194526007248 salt bridge; other site 1194526007249 sequence-specific DNA binding site [nucleotide binding]; other site 1194526007250 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1194526007251 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1194526007252 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1194526007253 Walker A/P-loop; other site 1194526007254 ATP binding site [chemical binding]; other site 1194526007255 Q-loop/lid; other site 1194526007256 ABC transporter signature motif; other site 1194526007257 Walker B; other site 1194526007258 D-loop; other site 1194526007259 H-loop/switch region; other site 1194526007260 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1194526007261 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1194526007262 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1194526007263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1194526007264 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1194526007265 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1194526007266 Catalytic site [active] 1194526007267 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1194526007268 Walker A/P-loop; other site 1194526007269 ATP binding site [chemical binding]; other site 1194526007270 ABC transporter; Region: ABC_tran; pfam00005 1194526007271 Q-loop/lid; other site 1194526007272 ABC transporter signature motif; other site 1194526007273 Walker B; other site 1194526007274 D-loop; other site 1194526007275 H-loop/switch region; other site 1194526007276 FtsX-like permease family; Region: FtsX; pfam02687 1194526007277 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1194526007278 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1194526007279 PGAP1-like protein; Region: PGAP1; pfam07819 1194526007280 flagellin modification protein A; Provisional; Region: PRK09186 1194526007281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526007282 NAD(P) binding site [chemical binding]; other site 1194526007283 active site 1194526007284 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1194526007285 potential frameshift: common BLAST hit: gi|73663504|ref|YP_302285.1| teichoic acid translocation permease 1194526007286 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1194526007287 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1194526007288 putative NAD(P) binding site [chemical binding]; other site 1194526007289 homodimer interface [polypeptide binding]; other site 1194526007290 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1194526007291 conserved cys residue [active] 1194526007292 CAAX protease self-immunity; Region: Abi; pfam02517 1194526007293 FemAB family; Region: FemAB; pfam02388 1194526007294 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1194526007295 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1194526007296 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1194526007297 putative NAD(P) binding site [chemical binding]; other site 1194526007298 catalytic Zn binding site [ion binding]; other site 1194526007299 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1194526007300 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1194526007301 FtsX-like permease family; Region: FtsX; pfam02687 1194526007302 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1194526007303 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1194526007304 Walker A/P-loop; other site 1194526007305 ATP binding site [chemical binding]; other site 1194526007306 Q-loop/lid; other site 1194526007307 ABC transporter signature motif; other site 1194526007308 Walker B; other site 1194526007309 D-loop; other site 1194526007310 H-loop/switch region; other site 1194526007311 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1194526007312 HlyD family secretion protein; Region: HlyD_3; pfam13437 1194526007313 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1194526007314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1194526007315 non-specific DNA binding site [nucleotide binding]; other site 1194526007316 salt bridge; other site 1194526007317 sequence-specific DNA binding site [nucleotide binding]; other site 1194526007318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526007319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526007320 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1194526007321 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1194526007322 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1194526007323 ParB-like nuclease domain; Region: ParBc; pfam02195 1194526007324 KorB domain; Region: KorB; pfam08535 1194526007325 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1194526007326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526007327 S-adenosylmethionine binding site [chemical binding]; other site 1194526007328 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1194526007329 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1194526007330 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1194526007331 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1194526007332 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1194526007333 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1194526007334 G1 box; other site 1194526007335 GTP/Mg2+ binding site [chemical binding]; other site 1194526007336 Switch I region; other site 1194526007337 G2 box; other site 1194526007338 Switch II region; other site 1194526007339 G3 box; other site 1194526007340 G4 box; other site 1194526007341 G5 box; other site 1194526007342 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1194526007343 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1194526007344 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1194526007345 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1194526007346 Domain of unknown function (DUF334); Region: DUF334; pfam03904 1194526007347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1194526007348 Replication initiation factor; Region: Rep_trans; pfam02486 1194526007349 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1194526007350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007351 Integrase core domain; Region: rve; pfam00665 1194526007352 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1194526007353 DNA-binding site [nucleotide binding]; DNA binding site 1194526007354 RNA-binding motif; other site 1194526007355 Initiator Replication protein; Region: Rep_3; pfam01051 1194526007356 PemK-like protein; Region: PemK; cl00995 1194526007357 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1194526007358 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1194526007359 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1194526007360 P-loop; other site 1194526007361 Magnesium ion binding site [ion binding]; other site 1194526007362 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1194526007363 Magnesium ion binding site [ion binding]; other site 1194526007364 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1194526007365 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1194526007366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007367 Integrase core domain; Region: rve; pfam00665 1194526007368 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1194526007369 beta-lactamase TEM; Provisional; Region: PRK15442 1194526007370 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1194526007371 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1194526007372 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1194526007373 Predicted transcriptional regulator [Transcription]; Region: COG3682 1194526007374 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1194526007375 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1194526007376 catalytic residues [active] 1194526007377 catalytic nucleophile [active] 1194526007378 Presynaptic Site I dimer interface [polypeptide binding]; other site 1194526007379 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1194526007380 Synaptic Flat tetramer interface [polypeptide binding]; other site 1194526007381 Synaptic Site I dimer interface [polypeptide binding]; other site 1194526007382 DNA binding site [nucleotide binding] 1194526007383 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1194526007384 DNA-binding interface [nucleotide binding]; DNA binding site 1194526007385 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1194526007386 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1194526007387 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1194526007388 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1194526007389 catalytic residues [active] 1194526007390 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1194526007391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526007392 Coenzyme A binding pocket [chemical binding]; other site 1194526007393 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1194526007394 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1194526007395 metal-binding site [ion binding] 1194526007396 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1194526007397 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1194526007398 metal-binding site [ion binding] 1194526007399 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1194526007400 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1194526007401 metal-binding site [ion binding] 1194526007402 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1194526007403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1194526007404 motif II; other site 1194526007405 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1194526007406 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1194526007407 metal-binding site [ion binding] 1194526007408 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1194526007409 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1194526007410 putative transposase OrfB; Reviewed; Region: PHA02517 1194526007411 HTH-like domain; Region: HTH_21; pfam13276 1194526007412 Integrase core domain; Region: rve; pfam00665 1194526007413 Integrase core domain; Region: rve_3; cl15866 1194526007414 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1194526007415 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1194526007416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1194526007417 sequence-specific DNA binding site [nucleotide binding]; other site 1194526007418 salt bridge; other site 1194526007419 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1194526007420 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1194526007421 catalytic residues [active] 1194526007422 catalytic nucleophile [active] 1194526007423 Presynaptic Site I dimer interface [polypeptide binding]; other site 1194526007424 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1194526007425 Synaptic Flat tetramer interface [polypeptide binding]; other site 1194526007426 Synaptic Site I dimer interface [polypeptide binding]; other site 1194526007427 DNA binding site [nucleotide binding] 1194526007428 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1194526007429 DNA-binding interface [nucleotide binding]; DNA binding site 1194526007430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007431 Integrase core domain; Region: rve; pfam00665 1194526007432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007433 Integrase core domain; Region: rve; pfam00665 1194526007434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007435 Integrase core domain; Region: rve; pfam00665 1194526007436 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1194526007437 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1194526007438 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1194526007439 active site 1194526007440 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1194526007441 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1194526007442 putative homodimer interface [polypeptide binding]; other site 1194526007443 putative homotetramer interface [polypeptide binding]; other site 1194526007444 putative metal binding site [ion binding]; other site 1194526007445 putative homodimer-homodimer interface [polypeptide binding]; other site 1194526007446 putative allosteric switch controlling residues; other site 1194526007447 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1194526007448 active site residue [active] 1194526007449 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 1194526007450 CPxP motif; other site 1194526007451 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1194526007452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1194526007453 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1194526007454 active site residue [active] 1194526007455 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1194526007456 active site residue [active] 1194526007457 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1194526007458 Domain of unknown function DUF21; Region: DUF21; pfam01595 1194526007459 FOG: CBS domain [General function prediction only]; Region: COG0517 1194526007460 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1194526007461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007462 Integrase core domain; Region: rve; pfam00665 1194526007463 Predicted transcriptional regulators [Transcription]; Region: COG1733 1194526007464 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1194526007465 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1194526007466 tetramer interface [polypeptide binding]; other site 1194526007467 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1194526007468 active site 1194526007469 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1194526007470 active site 1194526007471 dimer interface [polypeptide binding]; other site 1194526007472 magnesium binding site [ion binding]; other site 1194526007473 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1194526007474 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1194526007475 active site 1194526007476 dimer interface [polypeptide binding]; other site 1194526007477 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1194526007478 dimer interface [polypeptide binding]; other site 1194526007479 active site 1194526007480 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1194526007481 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1194526007482 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1194526007483 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1194526007484 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1194526007485 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1194526007486 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1194526007487 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1194526007488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007489 Integrase core domain; Region: rve; pfam00665 1194526007490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007491 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 1194526007492 Replication initiation factor; Region: Rep_trans; pfam02486 1194526007493 trehalose repressor; Provisional; Region: treR; PRK09492 1194526007494 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1194526007495 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1194526007496 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1194526007497 Replication initiation factor; Region: Rep_trans; pfam02486 1194526007498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007499 Cold shock proteins [Transcription]; Region: CspC; COG1278 1194526007500 RNA binding site [nucleotide binding]; other site 1194526007501 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1194526007502 nuclear-egress-membrane-like protein; Provisional; Region: PHA03325 1194526007503 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1194526007504 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1194526007505 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1194526007506 potential frameshift: common BLAST hit: gi|385782936|ref|YP_005756450.1| transposase IS66 family protein 1194526007507 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1194526007508 HTH domain; Region: HTH_11; cl17392 1194526007509 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1194526007510 Switch II region; other site 1194526007511 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1194526007512 Integrase core domain; Region: rve; pfam00665 1194526007513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007514 Integrase core domain; Region: rve; pfam00665 1194526007515 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1194526007516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1194526007517 Walker A/P-loop; other site 1194526007518 ATP binding site [chemical binding]; other site 1194526007519 Q-loop/lid; other site 1194526007520 ABC transporter signature motif; other site 1194526007521 Walker B; other site 1194526007522 D-loop; other site 1194526007523 H-loop/switch region; other site 1194526007524 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1194526007525 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1194526007526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1194526007527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1194526007528 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1194526007529 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1194526007530 active site 1194526007531 NTP binding site [chemical binding]; other site 1194526007532 metal binding triad [ion binding]; metal-binding site 1194526007533 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1194526007534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1194526007535 S-adenosylmethionine binding site [chemical binding]; other site 1194526007536 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1194526007537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1194526007538 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1194526007539 Coenzyme A binding pocket [chemical binding]; other site 1194526007540 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1194526007541 active site 1194526007542 ATP binding site [chemical binding]; other site 1194526007543 Phosphotransferase enzyme family; Region: APH; pfam01636 1194526007544 antibiotic binding site [chemical binding]; other site 1194526007545 Predicted transcriptional regulator [Transcription]; Region: COG2378 1194526007546 HTH domain; Region: HTH_11; pfam08279 1194526007547 WYL domain; Region: WYL; pfam13280 1194526007548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1194526007549 Integrase core domain; Region: rve; pfam00665