-- dump date 20140620_080432 -- class Genbank::misc_feature -- table misc_feature_note -- id note 639283000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 639283000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 639283000003 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 639283000004 DnaA box-binding interface [nucleotide binding]; other site 639283000005 HNH endonuclease; Region: HNH_3; pfam13392 639283000006 DNA methylase; Region: N6_N4_Mtase; cl17433 639283000007 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 639283000008 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 639283000009 DNA methylase; Region: N6_N4_Mtase; pfam01555 639283000010 TSCPD domain; Region: TSCPD; cl14834 639283000011 Methyltransferase domain; Region: Methyltransf_23; pfam13489 639283000012 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 639283000013 non-specific DNA interactions [nucleotide binding]; other site 639283000014 DNA binding site [nucleotide binding] 639283000015 sequence specific DNA binding site [nucleotide binding]; other site 639283000016 putative cAMP binding site [chemical binding]; other site 639283000017 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 639283000018 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 639283000019 active site 639283000020 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 639283000021 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 639283000022 Phage portal protein; Region: Phage_portal; pfam04860 639283000023 Phage-related protein [Function unknown]; Region: COG4695 639283000024 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 639283000025 oligomer interface [polypeptide binding]; other site 639283000026 Clp protease; Region: CLP_protease; pfam00574 639283000027 active site residues [active] 639283000028 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 639283000029 Phage capsid family; Region: Phage_capsid; pfam05065 639283000030 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 639283000031 oligomerization interface [polypeptide binding]; other site 639283000032 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 639283000033 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 639283000034 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 639283000035 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 639283000036 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 639283000037 tape measure domain; Region: tape_meas_nterm; TIGR02675 639283000038 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 639283000039 Putative phage tail protein; Region: Phage-tail_3; pfam13550 639283000040 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 639283000041 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 639283000042 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 639283000043 catalytic residue [active] 639283000044 Methyltransferase domain; Region: Methyltransf_12; pfam08242 639283000045 Uncharacterized conserved protein [Function unknown]; Region: COG2135 639283000046 PII uridylyl-transferase; Provisional; Region: PRK05092 639283000047 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 639283000048 metal binding triad; other site 639283000049 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 639283000050 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 639283000051 Zn2+ binding site [ion binding]; other site 639283000052 Mg2+ binding site [ion binding]; other site 639283000053 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 639283000054 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 639283000055 PRC-barrel domain; Region: PRC; pfam05239 639283000056 PAS fold; Region: PAS_4; pfam08448 639283000057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283000058 putative active site [active] 639283000059 heme pocket [chemical binding]; other site 639283000060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 639283000061 HWE histidine kinase; Region: HWE_HK; pfam07536 639283000062 two-component response regulator; Provisional; Region: PRK09191 639283000063 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 639283000064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283000065 active site 639283000066 phosphorylation site [posttranslational modification] 639283000067 intermolecular recognition site; other site 639283000068 dimerization interface [polypeptide binding]; other site 639283000069 RNA polymerase sigma factor; Provisional; Region: PRK12540 639283000070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283000071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 639283000072 DNA binding residues [nucleotide binding] 639283000073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283000074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283000075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 639283000076 dimerization interface [polypeptide binding]; other site 639283000077 RmuC family; Region: RmuC; pfam02646 639283000078 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 639283000079 active site 639283000080 catalytic residues [active] 639283000081 metal binding site [ion binding]; metal-binding site 639283000082 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 639283000083 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 639283000084 putative active site [active] 639283000085 substrate binding site [chemical binding]; other site 639283000086 putative cosubstrate binding site; other site 639283000087 catalytic site [active] 639283000088 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 639283000089 substrate binding site [chemical binding]; other site 639283000090 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 639283000091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283000092 Coenzyme A binding pocket [chemical binding]; other site 639283000093 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 639283000094 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 639283000095 dimer interface [polypeptide binding]; other site 639283000096 decamer (pentamer of dimers) interface [polypeptide binding]; other site 639283000097 catalytic triad [active] 639283000098 Predicted transcriptional regulator [Transcription]; Region: COG2932 639283000099 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 639283000100 non-specific DNA binding site [nucleotide binding]; other site 639283000101 salt bridge; other site 639283000102 sequence-specific DNA binding site [nucleotide binding]; other site 639283000103 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 639283000104 Catalytic site [active] 639283000105 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 639283000106 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283000107 catalytic residue [active] 639283000108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 639283000109 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 639283000110 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 639283000111 quinone interaction residues [chemical binding]; other site 639283000112 active site 639283000113 catalytic residues [active] 639283000114 FMN binding site [chemical binding]; other site 639283000115 substrate binding site [chemical binding]; other site 639283000116 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 639283000117 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 639283000118 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 639283000119 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 639283000120 active site 639283000121 DNA binding site [nucleotide binding] 639283000122 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 639283000123 DNA binding site [nucleotide binding] 639283000124 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 639283000125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 639283000126 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 639283000127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283000128 S-adenosylmethionine binding site [chemical binding]; other site 639283000129 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 639283000130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 639283000131 ATP binding site [chemical binding]; other site 639283000132 putative Mg++ binding site [ion binding]; other site 639283000133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 639283000134 nucleotide binding region [chemical binding]; other site 639283000135 ATP-binding site [chemical binding]; other site 639283000136 DEAD/H associated; Region: DEAD_assoc; pfam08494 639283000137 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 639283000138 putative active site [active] 639283000139 putative metal binding site [ion binding]; other site 639283000140 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 639283000141 Sel1-like repeats; Region: SEL1; smart00671 639283000142 Sel1-like repeats; Region: SEL1; smart00671 639283000143 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 639283000144 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 639283000145 DNA binding residues [nucleotide binding] 639283000146 putative dimer interface [polypeptide binding]; other site 639283000147 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 639283000148 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 639283000149 putative catalytic residue [active] 639283000150 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 639283000151 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 639283000152 substrate binding pocket [chemical binding]; other site 639283000153 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 639283000154 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 639283000155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 639283000156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283000157 active site 639283000158 phosphorylation site [posttranslational modification] 639283000159 intermolecular recognition site; other site 639283000160 dimerization interface [polypeptide binding]; other site 639283000161 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283000162 DNA binding residues [nucleotide binding] 639283000163 dimerization interface [polypeptide binding]; other site 639283000164 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 639283000165 Na binding site [ion binding]; other site 639283000166 PAS domain; Region: PAS; smart00091 639283000167 PAS fold; Region: PAS_7; pfam12860 639283000168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283000169 dimer interface [polypeptide binding]; other site 639283000170 phosphorylation site [posttranslational modification] 639283000171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283000172 ATP binding site [chemical binding]; other site 639283000173 Mg2+ binding site [ion binding]; other site 639283000174 G-X-G motif; other site 639283000175 Response regulator receiver domain; Region: Response_reg; pfam00072 639283000176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283000177 active site 639283000178 phosphorylation site [posttranslational modification] 639283000179 intermolecular recognition site; other site 639283000180 dimerization interface [polypeptide binding]; other site 639283000181 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 639283000182 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 639283000183 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 639283000184 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 639283000185 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 639283000186 NAD binding site [chemical binding]; other site 639283000187 substrate binding site [chemical binding]; other site 639283000188 homodimer interface [polypeptide binding]; other site 639283000189 active site 639283000190 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 639283000191 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 639283000192 NADP binding site [chemical binding]; other site 639283000193 active site 639283000194 putative substrate binding site [chemical binding]; other site 639283000195 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 639283000196 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 639283000197 substrate binding site; other site 639283000198 tetramer interface; other site 639283000199 aspartate aminotransferase; Provisional; Region: PRK06108 639283000200 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283000201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283000202 homodimer interface [polypeptide binding]; other site 639283000203 catalytic residue [active] 639283000204 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 639283000205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283000206 putative active site [active] 639283000207 heme pocket [chemical binding]; other site 639283000208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283000209 dimer interface [polypeptide binding]; other site 639283000210 phosphorylation site [posttranslational modification] 639283000211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283000212 ATP binding site [chemical binding]; other site 639283000213 Mg2+ binding site [ion binding]; other site 639283000214 G-X-G motif; other site 639283000215 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 639283000216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283000217 active site 639283000218 phosphorylation site [posttranslational modification] 639283000219 intermolecular recognition site; other site 639283000220 dimerization interface [polypeptide binding]; other site 639283000221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283000222 DNA binding residues [nucleotide binding] 639283000223 dimerization interface [polypeptide binding]; other site 639283000224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283000225 active site 639283000226 phosphorylation site [posttranslational modification] 639283000227 intermolecular recognition site; other site 639283000228 dimerization interface [polypeptide binding]; other site 639283000229 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 639283000230 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 639283000231 ligand binding site [chemical binding]; other site 639283000232 flexible hinge region; other site 639283000233 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 639283000234 putative switch regulator; other site 639283000235 non-specific DNA interactions [nucleotide binding]; other site 639283000236 DNA binding site [nucleotide binding] 639283000237 sequence specific DNA binding site [nucleotide binding]; other site 639283000238 putative cAMP binding site [chemical binding]; other site 639283000239 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 639283000240 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283000241 FeS/SAM binding site; other site 639283000242 HemN C-terminal domain; Region: HemN_C; pfam06969 639283000243 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 639283000244 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 639283000245 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 639283000246 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 639283000247 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 639283000248 substrate-cofactor binding pocket; other site 639283000249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283000250 catalytic residue [active] 639283000251 agmatinase; Region: agmatinase; TIGR01230 639283000252 Agmatinase-like family; Region: Agmatinase-like; cd09990 639283000253 active site 639283000254 oligomer interface [polypeptide binding]; other site 639283000255 Mn binding site [ion binding]; other site 639283000256 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 639283000257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283000258 active site 639283000259 hypothetical protein; Validated; Region: PRK07198 639283000260 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 639283000261 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 639283000262 dimerization interface [polypeptide binding]; other site 639283000263 active site 639283000264 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 639283000265 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 639283000266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283000267 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283000268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283000269 Walker A/P-loop; other site 639283000270 ATP binding site [chemical binding]; other site 639283000271 Q-loop/lid; other site 639283000272 ABC transporter signature motif; other site 639283000273 Walker B; other site 639283000274 D-loop; other site 639283000275 H-loop/switch region; other site 639283000276 TOBE domain; Region: TOBE_2; pfam08402 639283000277 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283000278 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283000279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283000280 dimer interface [polypeptide binding]; other site 639283000281 conserved gate region; other site 639283000282 putative PBP binding loops; other site 639283000283 ABC-ATPase subunit interface; other site 639283000284 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283000285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283000286 dimer interface [polypeptide binding]; other site 639283000287 conserved gate region; other site 639283000288 putative PBP binding loops; other site 639283000289 ABC-ATPase subunit interface; other site 639283000290 Helix-turn-helix domain; Region: HTH_18; pfam12833 639283000291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283000292 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 639283000293 Autotransporter beta-domain; Region: Autotransporter; pfam03797 639283000294 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283000295 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283000296 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283000297 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283000298 TM-ABC transporter signature motif; other site 639283000299 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 639283000300 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 639283000301 Walker A/P-loop; other site 639283000302 ATP binding site [chemical binding]; other site 639283000303 Q-loop/lid; other site 639283000304 ABC transporter signature motif; other site 639283000305 Walker B; other site 639283000306 D-loop; other site 639283000307 H-loop/switch region; other site 639283000308 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 639283000309 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 639283000310 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 639283000311 putative ligand binding site [chemical binding]; other site 639283000312 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 639283000313 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 639283000314 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 639283000315 active site 639283000316 catalytic residues [active] 639283000317 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 639283000318 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 639283000319 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 639283000320 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 639283000321 inhibitor site; inhibition site 639283000322 active site 639283000323 dimer interface [polypeptide binding]; other site 639283000324 catalytic residue [active] 639283000325 dihydroxy-acid dehydratase; Validated; Region: PRK06131 639283000326 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283000327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283000328 DNA-binding site [nucleotide binding]; DNA binding site 639283000329 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 639283000330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283000331 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283000332 TM-ABC transporter signature motif; other site 639283000333 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 639283000334 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283000335 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283000336 TM-ABC transporter signature motif; other site 639283000337 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 639283000338 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 639283000339 Walker A/P-loop; other site 639283000340 ATP binding site [chemical binding]; other site 639283000341 Q-loop/lid; other site 639283000342 ABC transporter signature motif; other site 639283000343 Walker B; other site 639283000344 D-loop; other site 639283000345 H-loop/switch region; other site 639283000346 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 639283000347 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 639283000348 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 639283000349 putative ligand binding site [chemical binding]; other site 639283000350 Domain of unknown function (DUF329); Region: DUF329; cl01144 639283000351 Maf-like protein; Region: Maf; pfam02545 639283000352 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 639283000353 active site 639283000354 dimer interface [polypeptide binding]; other site 639283000355 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 639283000356 Low molecular weight phosphatase family; Region: LMWPc; cd00115 639283000357 active site 639283000358 hypothetical protein; Provisional; Region: PRK02853 639283000359 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 639283000360 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 639283000361 NAD binding site [chemical binding]; other site 639283000362 dimerization interface [polypeptide binding]; other site 639283000363 product binding site; other site 639283000364 substrate binding site [chemical binding]; other site 639283000365 zinc binding site [ion binding]; other site 639283000366 catalytic residues [active] 639283000367 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 639283000368 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 639283000369 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 639283000370 hinge; other site 639283000371 active site 639283000372 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 639283000373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283000374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283000375 dimerization interface [polypeptide binding]; other site 639283000376 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 639283000377 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 639283000378 Sulfatase; Region: Sulfatase; cl17466 639283000379 choline-sulfatase; Region: chol_sulfatase; TIGR03417 639283000380 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 639283000381 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 639283000382 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 639283000383 Walker A/P-loop; other site 639283000384 ATP binding site [chemical binding]; other site 639283000385 Q-loop/lid; other site 639283000386 ABC transporter signature motif; other site 639283000387 Walker B; other site 639283000388 D-loop; other site 639283000389 H-loop/switch region; other site 639283000390 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 639283000391 FtsX-like permease family; Region: FtsX; pfam02687 639283000392 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283000393 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283000394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283000395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283000396 active site 639283000397 phosphorylation site [posttranslational modification] 639283000398 intermolecular recognition site; other site 639283000399 dimerization interface [polypeptide binding]; other site 639283000400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283000401 DNA binding site [nucleotide binding] 639283000402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 639283000403 dimerization interface [polypeptide binding]; other site 639283000404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283000405 ATP binding site [chemical binding]; other site 639283000406 Mg2+ binding site [ion binding]; other site 639283000407 G-X-G motif; other site 639283000408 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283000409 FOG: CBS domain [General function prediction only]; Region: COG0517 639283000410 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 639283000411 BON domain; Region: BON; pfam04972 639283000412 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 639283000413 Domain of unknown function DUF20; Region: UPF0118; pfam01594 639283000414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 639283000415 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 639283000416 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 639283000417 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 639283000418 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 639283000419 active site 639283000420 nucleophile elbow; other site 639283000421 Protein of unknown function (DUF2717); Region: DUF2717; cl17568 639283000422 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 639283000423 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 639283000424 arginine deiminase; Provisional; Region: PRK01388 639283000425 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 639283000426 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 639283000427 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 639283000428 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 639283000429 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 639283000430 active site pocket [active] 639283000431 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 639283000432 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 639283000433 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 639283000434 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 639283000435 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 639283000436 inhibitor site; inhibition site 639283000437 active site 639283000438 dimer interface [polypeptide binding]; other site 639283000439 catalytic residue [active] 639283000440 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283000441 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 639283000442 Walker A/P-loop; other site 639283000443 ATP binding site [chemical binding]; other site 639283000444 Q-loop/lid; other site 639283000445 ABC transporter signature motif; other site 639283000446 Walker B; other site 639283000447 D-loop; other site 639283000448 H-loop/switch region; other site 639283000449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283000450 dimer interface [polypeptide binding]; other site 639283000451 conserved gate region; other site 639283000452 putative PBP binding loops; other site 639283000453 ABC-ATPase subunit interface; other site 639283000454 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283000455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283000456 dimer interface [polypeptide binding]; other site 639283000457 conserved gate region; other site 639283000458 putative PBP binding loops; other site 639283000459 ABC-ATPase subunit interface; other site 639283000460 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283000461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283000462 substrate binding pocket [chemical binding]; other site 639283000463 membrane-bound complex binding site; other site 639283000464 hinge residues; other site 639283000465 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 639283000466 dimerization interface [polypeptide binding]; other site 639283000467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283000468 ATP binding site [chemical binding]; other site 639283000469 Mg2+ binding site [ion binding]; other site 639283000470 G-X-G motif; other site 639283000471 osmolarity response regulator; Provisional; Region: ompR; PRK09468 639283000472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283000473 active site 639283000474 phosphorylation site [posttranslational modification] 639283000475 intermolecular recognition site; other site 639283000476 dimerization interface [polypeptide binding]; other site 639283000477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283000478 DNA binding site [nucleotide binding] 639283000479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283000480 S-adenosylmethionine binding site [chemical binding]; other site 639283000481 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 639283000482 Predicted transcriptional regulators [Transcription]; Region: COG1510 639283000483 allantoate amidohydrolase; Reviewed; Region: PRK12891 639283000484 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 639283000485 active site 639283000486 metal binding site [ion binding]; metal-binding site 639283000487 dimer interface [polypeptide binding]; other site 639283000488 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 639283000489 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 639283000490 ligand binding site [chemical binding]; other site 639283000491 NAD binding site [chemical binding]; other site 639283000492 dimerization interface [polypeptide binding]; other site 639283000493 catalytic site [active] 639283000494 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 639283000495 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 639283000496 putative NAD(P) binding site [chemical binding]; other site 639283000497 putative active site [active] 639283000498 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 639283000499 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 639283000500 inhibitor site; inhibition site 639283000501 active site 639283000502 dimer interface [polypeptide binding]; other site 639283000503 catalytic residue [active] 639283000504 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283000505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283000506 DNA-binding site [nucleotide binding]; DNA binding site 639283000507 FCD domain; Region: FCD; pfam07729 639283000508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283000509 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283000510 substrate binding pocket [chemical binding]; other site 639283000511 membrane-bound complex binding site; other site 639283000512 hinge residues; other site 639283000513 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 639283000514 agmatinase; Region: agmatinase; TIGR01230 639283000515 oligomer interface [polypeptide binding]; other site 639283000516 putative active site [active] 639283000517 Mn binding site [ion binding]; other site 639283000518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283000519 dimer interface [polypeptide binding]; other site 639283000520 conserved gate region; other site 639283000521 putative PBP binding loops; other site 639283000522 ABC-ATPase subunit interface; other site 639283000523 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283000524 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 639283000525 Walker A/P-loop; other site 639283000526 ATP binding site [chemical binding]; other site 639283000527 Q-loop/lid; other site 639283000528 ABC transporter signature motif; other site 639283000529 Walker B; other site 639283000530 D-loop; other site 639283000531 H-loop/switch region; other site 639283000532 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 639283000533 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 639283000534 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 639283000535 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 639283000536 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 639283000537 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 639283000538 putative active site [active] 639283000539 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 639283000540 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 639283000541 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 639283000542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283000543 DNA-binding site [nucleotide binding]; DNA binding site 639283000544 UTRA domain; Region: UTRA; pfam07702 639283000545 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 639283000546 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 639283000547 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 639283000548 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283000549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 639283000550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283000551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283000552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283000553 dimerization interface [polypeptide binding]; other site 639283000554 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 639283000555 Uncharacterized conserved protein [Function unknown]; Region: COG2128 639283000556 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 639283000557 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 639283000558 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 639283000559 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 639283000560 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 639283000561 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 639283000562 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 639283000563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283000564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283000565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 639283000566 dimerization interface [polypeptide binding]; other site 639283000567 Cupin domain; Region: Cupin_2; pfam07883 639283000568 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 639283000569 Cupin domain; Region: Cupin_2; pfam07883 639283000570 Amidohydrolase; Region: Amidohydro_2; pfam04909 639283000571 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 639283000572 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283000573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283000574 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 639283000575 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 639283000576 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 639283000577 Uncharacterized conserved protein [Function unknown]; Region: COG5276 639283000578 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283000579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283000580 DNA-binding site [nucleotide binding]; DNA binding site 639283000581 FCD domain; Region: FCD; pfam07729 639283000582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283000583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283000584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 639283000585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 639283000586 active site 639283000587 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283000588 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 639283000589 dimer interface [polypeptide binding]; other site 639283000590 putative metal binding site [ion binding]; other site 639283000591 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 639283000592 histidinol dehydrogenase; Region: hisD; TIGR00069 639283000593 NAD binding site [chemical binding]; other site 639283000594 dimerization interface [polypeptide binding]; other site 639283000595 product binding site; other site 639283000596 substrate binding site [chemical binding]; other site 639283000597 zinc binding site [ion binding]; other site 639283000598 catalytic residues [active] 639283000599 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283000600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283000601 DNA-binding site [nucleotide binding]; DNA binding site 639283000602 FCD domain; Region: FCD; pfam07729 639283000603 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283000604 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283000605 Walker A/P-loop; other site 639283000606 ATP binding site [chemical binding]; other site 639283000607 Q-loop/lid; other site 639283000608 ABC transporter signature motif; other site 639283000609 Walker B; other site 639283000610 D-loop; other site 639283000611 H-loop/switch region; other site 639283000612 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283000613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283000614 dimer interface [polypeptide binding]; other site 639283000615 conserved gate region; other site 639283000616 putative PBP binding loops; other site 639283000617 ABC-ATPase subunit interface; other site 639283000618 NMT1/THI5 like; Region: NMT1; pfam09084 639283000619 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 639283000620 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 639283000621 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 639283000622 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 639283000623 putative active site [active] 639283000624 putative catalytic site [active] 639283000625 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283000626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283000627 dimer interface [polypeptide binding]; other site 639283000628 conserved gate region; other site 639283000629 putative PBP binding loops; other site 639283000630 ABC-ATPase subunit interface; other site 639283000631 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283000632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 639283000633 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283000634 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283000635 Walker A/P-loop; other site 639283000636 ATP binding site [chemical binding]; other site 639283000637 Q-loop/lid; other site 639283000638 ABC transporter signature motif; other site 639283000639 Walker B; other site 639283000640 D-loop; other site 639283000641 H-loop/switch region; other site 639283000642 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 639283000643 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283000644 substrate binding pocket [chemical binding]; other site 639283000645 membrane-bound complex binding site; other site 639283000646 short chain dehydrogenase; Provisional; Region: PRK09134 639283000647 classical (c) SDRs; Region: SDR_c; cd05233 639283000648 NAD(P) binding site [chemical binding]; other site 639283000649 active site 639283000650 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 639283000651 Putative cyclase; Region: Cyclase; pfam04199 639283000652 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 639283000653 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 639283000654 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 639283000655 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 639283000656 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 639283000657 Domain of unknown function (DUF336); Region: DUF336; cl01249 639283000658 short chain dehydrogenase; Provisional; Region: PRK07478 639283000659 classical (c) SDRs; Region: SDR_c; cd05233 639283000660 NAD(P) binding site [chemical binding]; other site 639283000661 active site 639283000662 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 639283000663 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 639283000664 Walker A/P-loop; other site 639283000665 ATP binding site [chemical binding]; other site 639283000666 Q-loop/lid; other site 639283000667 ABC transporter signature motif; other site 639283000668 Walker B; other site 639283000669 D-loop; other site 639283000670 H-loop/switch region; other site 639283000671 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 639283000672 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 639283000673 FtsX-like permease family; Region: FtsX; pfam02687 639283000674 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 639283000675 FtsX-like permease family; Region: FtsX; pfam02687 639283000676 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283000677 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283000678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283000679 non-specific DNA binding site [nucleotide binding]; other site 639283000680 salt bridge; other site 639283000681 sequence-specific DNA binding site [nucleotide binding]; other site 639283000682 Cupin domain; Region: Cupin_2; pfam07883 639283000683 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 639283000684 homotrimer interaction site [polypeptide binding]; other site 639283000685 putative active site [active] 639283000686 MOSC domain; Region: MOSC; pfam03473 639283000687 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 639283000688 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 639283000689 FMN-binding pocket [chemical binding]; other site 639283000690 flavin binding motif; other site 639283000691 phosphate binding motif [ion binding]; other site 639283000692 beta-alpha-beta structure motif; other site 639283000693 NAD binding pocket [chemical binding]; other site 639283000694 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283000695 catalytic loop [active] 639283000696 iron binding site [ion binding]; other site 639283000697 metabolite-proton symporter; Region: 2A0106; TIGR00883 639283000698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283000699 putative substrate translocation pore; other site 639283000700 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 639283000701 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 639283000702 ATP binding site [chemical binding]; other site 639283000703 substrate interface [chemical binding]; other site 639283000704 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 639283000705 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 639283000706 dimerization interface [polypeptide binding]; other site 639283000707 ligand binding site [chemical binding]; other site 639283000708 NADP binding site [chemical binding]; other site 639283000709 catalytic site [active] 639283000710 Bacterial SH3 domain; Region: SH3_4; pfam06347 639283000711 Bacterial SH3 domain; Region: SH3_4; pfam06347 639283000712 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 639283000713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283000714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283000715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283000716 dimerization interface [polypeptide binding]; other site 639283000717 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 639283000718 metal binding site 2 [ion binding]; metal-binding site 639283000719 putative DNA binding helix; other site 639283000720 metal binding site 1 [ion binding]; metal-binding site 639283000721 dimer interface [polypeptide binding]; other site 639283000722 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 639283000723 active site 1 [active] 639283000724 dimer interface [polypeptide binding]; other site 639283000725 active site 2 [active] 639283000726 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 639283000727 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 639283000728 dimer interface [polypeptide binding]; other site 639283000729 active site 639283000730 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 639283000731 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 639283000732 NAD binding site [chemical binding]; other site 639283000733 homotetramer interface [polypeptide binding]; other site 639283000734 homodimer interface [polypeptide binding]; other site 639283000735 substrate binding site [chemical binding]; other site 639283000736 active site 639283000737 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 639283000738 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283000739 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 639283000740 active site 639283000741 prephenate dehydratase; Provisional; Region: PRK11899 639283000742 Prephenate dehydratase; Region: PDT; pfam00800 639283000743 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 639283000744 putative L-Phe binding site [chemical binding]; other site 639283000745 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 639283000746 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 639283000747 Ligand binding site; other site 639283000748 oligomer interface; other site 639283000749 Cytochrome c; Region: Cytochrom_C; cl11414 639283000750 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 639283000751 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 639283000752 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 639283000753 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 639283000754 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 639283000755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283000756 dimer interface [polypeptide binding]; other site 639283000757 conserved gate region; other site 639283000758 ABC-ATPase subunit interface; other site 639283000759 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 639283000760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283000761 ABC-ATPase subunit interface; other site 639283000762 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 639283000763 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 639283000764 Walker A/P-loop; other site 639283000765 ATP binding site [chemical binding]; other site 639283000766 Q-loop/lid; other site 639283000767 ABC transporter signature motif; other site 639283000768 Walker B; other site 639283000769 D-loop; other site 639283000770 H-loop/switch region; other site 639283000771 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 639283000772 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 639283000773 Walker A/P-loop; other site 639283000774 ATP binding site [chemical binding]; other site 639283000775 Q-loop/lid; other site 639283000776 ABC transporter signature motif; other site 639283000777 Walker B; other site 639283000778 D-loop; other site 639283000779 H-loop/switch region; other site 639283000780 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 639283000781 dimer interface [polypeptide binding]; other site 639283000782 ADP-ribose binding site [chemical binding]; other site 639283000783 active site 639283000784 nudix motif; other site 639283000785 metal binding site [ion binding]; metal-binding site 639283000786 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 639283000787 NlpC/P60 family; Region: NLPC_P60; cl17555 639283000788 MarR family; Region: MarR; pfam01047 639283000789 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 639283000790 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 639283000791 interface (dimer of trimers) [polypeptide binding]; other site 639283000792 Substrate-binding/catalytic site; other site 639283000793 Zn-binding sites [ion binding]; other site 639283000794 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 639283000795 catalytic core [active] 639283000796 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 639283000797 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 639283000798 NAD binding site [chemical binding]; other site 639283000799 homotetramer interface [polypeptide binding]; other site 639283000800 homodimer interface [polypeptide binding]; other site 639283000801 substrate binding site [chemical binding]; other site 639283000802 active site 639283000803 chaperone protein DnaJ; Provisional; Region: PRK14299 639283000804 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 639283000805 HSP70 interaction site [polypeptide binding]; other site 639283000806 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 639283000807 substrate binding site [polypeptide binding]; other site 639283000808 dimer interface [polypeptide binding]; other site 639283000809 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 639283000810 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 639283000811 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 639283000812 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 639283000813 classical (c) SDRs; Region: SDR_c; cd05233 639283000814 NAD(P) binding site [chemical binding]; other site 639283000815 active site 639283000816 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 639283000817 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 639283000818 Cl binding site [ion binding]; other site 639283000819 oligomer interface [polypeptide binding]; other site 639283000820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283000821 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283000822 aminotransferase; Provisional; Region: PRK06105 639283000823 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 639283000824 inhibitor-cofactor binding pocket; inhibition site 639283000825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283000826 catalytic residue [active] 639283000827 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 639283000828 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 639283000829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283000830 motif II; other site 639283000831 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 639283000832 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 639283000833 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 639283000834 active site clefts [active] 639283000835 zinc binding site [ion binding]; other site 639283000836 dimer interface [polypeptide binding]; other site 639283000837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 639283000838 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 639283000839 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 639283000840 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 639283000841 MarR family; Region: MarR; pfam01047 639283000842 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283000843 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283000844 Walker A/P-loop; other site 639283000845 ATP binding site [chemical binding]; other site 639283000846 Q-loop/lid; other site 639283000847 ABC transporter signature motif; other site 639283000848 Walker B; other site 639283000849 D-loop; other site 639283000850 H-loop/switch region; other site 639283000851 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283000852 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283000853 Walker A/P-loop; other site 639283000854 ATP binding site [chemical binding]; other site 639283000855 Q-loop/lid; other site 639283000856 ABC transporter signature motif; other site 639283000857 Walker B; other site 639283000858 D-loop; other site 639283000859 H-loop/switch region; other site 639283000860 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283000861 TM-ABC transporter signature motif; other site 639283000862 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283000863 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283000864 TM-ABC transporter signature motif; other site 639283000865 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283000866 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 639283000867 putative ligand binding site [chemical binding]; other site 639283000868 EamA-like transporter family; Region: EamA; pfam00892 639283000869 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 639283000870 Coenzyme A binding pocket [chemical binding]; other site 639283000871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283000872 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283000873 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 639283000874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283000875 S-adenosylmethionine binding site [chemical binding]; other site 639283000876 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 639283000877 ABC1 family; Region: ABC1; cl17513 639283000878 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 639283000879 Flavoprotein; Region: Flavoprotein; pfam02441 639283000880 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 639283000881 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 639283000882 trimer interface [polypeptide binding]; other site 639283000883 active site 639283000884 Transcriptional regulator; Region: Rrf2; pfam02082 639283000885 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 639283000886 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 639283000887 dimer interface [polypeptide binding]; other site 639283000888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283000889 catalytic residue [active] 639283000890 PAS fold; Region: PAS_7; pfam12860 639283000891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283000892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283000893 dimer interface [polypeptide binding]; other site 639283000894 phosphorylation site [posttranslational modification] 639283000895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283000896 ATP binding site [chemical binding]; other site 639283000897 Mg2+ binding site [ion binding]; other site 639283000898 G-X-G motif; other site 639283000899 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 639283000900 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 639283000901 Phosphotransferase enzyme family; Region: APH; pfam01636 639283000902 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 639283000903 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 639283000904 Substrate binding site; other site 639283000905 metal-binding site 639283000906 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 639283000907 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 639283000908 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 639283000909 Part of AAA domain; Region: AAA_19; pfam13245 639283000910 Family description; Region: UvrD_C_2; pfam13538 639283000911 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 639283000912 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 639283000913 catalytic residues [active] 639283000914 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 639283000915 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 639283000916 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 639283000917 Cytochrome c; Region: Cytochrom_C; pfam00034 639283000918 EamA-like transporter family; Region: EamA; pfam00892 639283000919 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 639283000920 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 639283000921 putative NAD(P) binding site [chemical binding]; other site 639283000922 active site 639283000923 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 639283000924 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 639283000925 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283000926 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 639283000927 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 639283000928 23S rRNA binding site [nucleotide binding]; other site 639283000929 L21 binding site [polypeptide binding]; other site 639283000930 L13 binding site [polypeptide binding]; other site 639283000931 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 639283000932 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 639283000933 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 639283000934 dimer interface [polypeptide binding]; other site 639283000935 motif 1; other site 639283000936 active site 639283000937 motif 2; other site 639283000938 motif 3; other site 639283000939 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 639283000940 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 639283000941 putative tRNA-binding site [nucleotide binding]; other site 639283000942 B3/4 domain; Region: B3_4; pfam03483 639283000943 tRNA synthetase B5 domain; Region: B5; smart00874 639283000944 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 639283000945 motif 1; other site 639283000946 dimer interface [polypeptide binding]; other site 639283000947 motif 3; other site 639283000948 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 639283000949 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 639283000950 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 639283000951 Lysine efflux permease [General function prediction only]; Region: COG1279 639283000952 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 639283000953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283000954 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283000955 dimerization interface [polypeptide binding]; other site 639283000956 CysZ-like protein; Reviewed; Region: PRK12768 639283000957 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 639283000958 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 639283000959 minor groove reading motif; other site 639283000960 helix-hairpin-helix signature motif; other site 639283000961 substrate binding pocket [chemical binding]; other site 639283000962 active site 639283000963 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 639283000964 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 639283000965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283000966 Helix-turn-helix domain; Region: HTH_18; pfam12833 639283000967 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 639283000968 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 639283000969 DNA binding site [nucleotide binding] 639283000970 active site 639283000971 Predicted membrane protein [Function unknown]; Region: COG4125 639283000972 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 639283000973 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 639283000974 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 639283000975 catalytic core [active] 639283000976 dihydrodipicolinate reductase; Provisional; Region: PRK00048 639283000977 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 639283000978 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 639283000979 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 639283000980 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 639283000981 PYR/PP interface [polypeptide binding]; other site 639283000982 dimer interface [polypeptide binding]; other site 639283000983 TPP binding site [chemical binding]; other site 639283000984 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 639283000985 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 639283000986 TPP-binding site [chemical binding]; other site 639283000987 dimer interface [polypeptide binding]; other site 639283000988 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 639283000989 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 639283000990 putative valine binding site [chemical binding]; other site 639283000991 dimer interface [polypeptide binding]; other site 639283000992 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 639283000993 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 639283000994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283000995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283000996 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 639283000997 ketol-acid reductoisomerase; Provisional; Region: PRK05479 639283000998 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 639283000999 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 639283001000 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 639283001001 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 639283001002 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 639283001003 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 639283001004 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 639283001005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283001006 ATP binding site [chemical binding]; other site 639283001007 Mg2+ binding site [ion binding]; other site 639283001008 G-X-G motif; other site 639283001009 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 639283001010 ATP binding site [chemical binding]; other site 639283001011 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 639283001012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001013 dimer interface [polypeptide binding]; other site 639283001014 conserved gate region; other site 639283001015 putative PBP binding loops; other site 639283001016 ABC-ATPase subunit interface; other site 639283001017 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283001018 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 639283001019 Walker A/P-loop; other site 639283001020 ATP binding site [chemical binding]; other site 639283001021 Q-loop/lid; other site 639283001022 ABC transporter signature motif; other site 639283001023 Walker B; other site 639283001024 D-loop; other site 639283001025 H-loop/switch region; other site 639283001026 TOBE domain; Region: TOBE_2; pfam08402 639283001027 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 639283001028 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 639283001029 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 639283001030 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 639283001031 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 639283001032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283001033 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283001034 dimerization interface [polypeptide binding]; other site 639283001035 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 639283001036 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283001037 glutamate--cysteine ligase; Region: PLN02611 639283001038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283001039 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283001040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283001041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283001042 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 639283001043 putative effector binding pocket; other site 639283001044 dimerization interface [polypeptide binding]; other site 639283001045 carboxylate-amine ligase; Provisional; Region: PRK13515 639283001046 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 639283001047 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 639283001048 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 639283001049 UbiA prenyltransferase family; Region: UbiA; pfam01040 639283001050 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 639283001051 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 639283001052 catalytic site [active] 639283001053 putative active site [active] 639283001054 putative substrate binding site [chemical binding]; other site 639283001055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 639283001056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 639283001057 OstA-like protein; Region: OstA; pfam03968 639283001058 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 639283001059 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 639283001060 Walker A/P-loop; other site 639283001061 ATP binding site [chemical binding]; other site 639283001062 Q-loop/lid; other site 639283001063 ABC transporter signature motif; other site 639283001064 Walker B; other site 639283001065 D-loop; other site 639283001066 H-loop/switch region; other site 639283001067 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 639283001068 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 639283001069 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 639283001070 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 639283001071 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 639283001072 30S subunit binding site; other site 639283001073 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 639283001074 active site 639283001075 phosphorylation site [posttranslational modification] 639283001076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 639283001077 non-specific DNA binding site [nucleotide binding]; other site 639283001078 salt bridge; other site 639283001079 sequence-specific DNA binding site [nucleotide binding]; other site 639283001080 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 639283001081 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 639283001082 tetramer interface [polypeptide binding]; other site 639283001083 catalytic Zn binding site [ion binding]; other site 639283001084 NADP binding site [chemical binding]; other site 639283001085 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 639283001086 G1 box; other site 639283001087 GTP/Mg2+ binding site [chemical binding]; other site 639283001088 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 639283001089 Switch I region; other site 639283001090 G2 box; other site 639283001091 G3 box; other site 639283001092 Switch II region; other site 639283001093 G4 box; other site 639283001094 G5 box; other site 639283001095 membrane protein insertase; Provisional; Region: PRK01318 639283001096 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 639283001097 Ribonuclease P; Region: Ribonuclease_P; pfam00825 639283001098 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 639283001099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283001100 HAMP domain; Region: HAMP; pfam00672 639283001101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283001102 ATP binding site [chemical binding]; other site 639283001103 Mg2+ binding site [ion binding]; other site 639283001104 G-X-G motif; other site 639283001105 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 639283001106 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 639283001107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283001108 NAD(P) binding site [chemical binding]; other site 639283001109 active site 639283001110 Uncharacterized conserved protein [Function unknown]; Region: COG3777 639283001111 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 639283001112 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 639283001113 active site 2 [active] 639283001114 active site 1 [active] 639283001115 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 639283001116 carboxyltransferase (CT) interaction site; other site 639283001117 biotinylation site [posttranslational modification]; other site 639283001118 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 639283001119 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 639283001120 ATP-grasp domain; Region: ATP-grasp_4; cl17255 639283001121 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 639283001122 Predicted transcriptional regulators [Transcription]; Region: COG1378 639283001123 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 639283001124 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 639283001125 C-terminal domain interface [polypeptide binding]; other site 639283001126 sugar binding site [chemical binding]; other site 639283001127 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 639283001128 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 639283001129 CoA binding domain; Region: CoA_binding_2; pfam13380 639283001130 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 639283001131 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 639283001132 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 639283001133 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 639283001134 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 639283001135 metal binding site [ion binding]; metal-binding site 639283001136 substrate binding pocket [chemical binding]; other site 639283001137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283001138 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283001139 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 639283001140 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 639283001141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283001142 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283001143 substrate binding pocket [chemical binding]; other site 639283001144 membrane-bound complex binding site; other site 639283001145 hinge residues; other site 639283001146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001147 dimer interface [polypeptide binding]; other site 639283001148 conserved gate region; other site 639283001149 putative PBP binding loops; other site 639283001150 ABC-ATPase subunit interface; other site 639283001151 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283001152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283001153 Walker A/P-loop; other site 639283001154 ATP binding site [chemical binding]; other site 639283001155 Q-loop/lid; other site 639283001156 ABC transporter signature motif; other site 639283001157 Walker B; other site 639283001158 D-loop; other site 639283001159 H-loop/switch region; other site 639283001160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 639283001161 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 639283001162 Helix-turn-helix domain; Region: HTH_18; pfam12833 639283001163 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283001164 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 639283001165 short chain dehydrogenase; Provisional; Region: PRK06180 639283001166 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 639283001167 NADP binding site [chemical binding]; other site 639283001168 active site 639283001169 steroid binding site; other site 639283001170 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 639283001171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283001172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283001173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283001174 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 639283001175 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 639283001176 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283001177 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 639283001178 Walker A/P-loop; other site 639283001179 ATP binding site [chemical binding]; other site 639283001180 Q-loop/lid; other site 639283001181 ABC transporter signature motif; other site 639283001182 Walker B; other site 639283001183 D-loop; other site 639283001184 H-loop/switch region; other site 639283001185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001186 dimer interface [polypeptide binding]; other site 639283001187 conserved gate region; other site 639283001188 putative PBP binding loops; other site 639283001189 ABC-ATPase subunit interface; other site 639283001190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001191 dimer interface [polypeptide binding]; other site 639283001192 conserved gate region; other site 639283001193 putative PBP binding loops; other site 639283001194 ABC-ATPase subunit interface; other site 639283001195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283001196 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283001197 substrate binding pocket [chemical binding]; other site 639283001198 membrane-bound complex binding site; other site 639283001199 hinge residues; other site 639283001200 Transcriptional regulator [Transcription]; Region: IclR; COG1414 639283001201 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 639283001202 Bacterial transcriptional regulator; Region: IclR; pfam01614 639283001203 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 639283001204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283001205 NAD(P) binding site [chemical binding]; other site 639283001206 active site 639283001207 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 639283001208 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 639283001209 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 639283001210 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 639283001211 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 639283001212 conserved cys residue [active] 639283001213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283001214 Helix-turn-helix domain; Region: HTH_18; pfam12833 639283001215 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283001216 Uncharacterized conserved protein [Function unknown]; Region: COG3246 639283001217 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 639283001218 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 639283001219 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 639283001220 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 639283001221 active site 639283001222 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 639283001223 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283001224 catalytic loop [active] 639283001225 iron binding site [ion binding]; other site 639283001226 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 639283001227 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 639283001228 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 639283001229 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 639283001230 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 639283001231 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283001232 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 639283001233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 639283001234 ANTAR domain; Region: ANTAR; pfam03861 639283001235 NMT1-like family; Region: NMT1_2; pfam13379 639283001236 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 639283001237 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 639283001238 NMT1-like family; Region: NMT1_2; pfam13379 639283001239 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283001240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001241 putative PBP binding loops; other site 639283001242 dimer interface [polypeptide binding]; other site 639283001243 ABC-ATPase subunit interface; other site 639283001244 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283001245 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283001246 Walker A/P-loop; other site 639283001247 ATP binding site [chemical binding]; other site 639283001248 Q-loop/lid; other site 639283001249 ABC transporter signature motif; other site 639283001250 Walker B; other site 639283001251 D-loop; other site 639283001252 H-loop/switch region; other site 639283001253 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 639283001254 heme-binding site [chemical binding]; other site 639283001255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 639283001256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283001257 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 639283001258 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 639283001259 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 639283001260 sulfite reductase; Provisional; Region: PRK06214 639283001261 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 639283001262 FAD binding pocket [chemical binding]; other site 639283001263 conserved FAD binding motif [chemical binding]; other site 639283001264 phosphate binding motif [ion binding]; other site 639283001265 beta-alpha-beta structure motif; other site 639283001266 NAD binding pocket [chemical binding]; other site 639283001267 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 639283001268 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 639283001269 [4Fe-4S] binding site [ion binding]; other site 639283001270 molybdopterin cofactor binding site; other site 639283001271 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 639283001272 molybdopterin cofactor binding site; other site 639283001273 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 639283001274 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 639283001275 FAD binding pocket [chemical binding]; other site 639283001276 FAD binding motif [chemical binding]; other site 639283001277 phosphate binding motif [ion binding]; other site 639283001278 beta-alpha-beta structure motif; other site 639283001279 NAD binding pocket [chemical binding]; other site 639283001280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283001281 PAS fold; Region: PAS_3; pfam08447 639283001282 putative active site [active] 639283001283 heme pocket [chemical binding]; other site 639283001284 Transcriptional regulator; Region: Rrf2; cl17282 639283001285 Predicted transcriptional regulator [Transcription]; Region: COG1959 639283001286 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 639283001287 HPP family; Region: HPP; pfam04982 639283001288 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 639283001289 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 639283001290 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 639283001291 trimer interface [polypeptide binding]; other site 639283001292 putative Zn binding site [ion binding]; other site 639283001293 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 639283001294 glutaminase; Provisional; Region: PRK00971 639283001295 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 639283001296 glutamine synthetase; Region: PLN02284 639283001297 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 639283001298 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 639283001299 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 639283001300 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 639283001301 putative active site [active] 639283001302 catalytic site [active] 639283001303 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 639283001304 putative active site [active] 639283001305 catalytic site [active] 639283001306 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 639283001307 Found in ATP-dependent protease La (LON); Region: LON; smart00464 639283001308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283001309 Walker A motif; other site 639283001310 ATP binding site [chemical binding]; other site 639283001311 Walker B motif; other site 639283001312 arginine finger; other site 639283001313 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 639283001314 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 639283001315 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 639283001316 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 639283001317 putative dimer interface [polypeptide binding]; other site 639283001318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283001319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283001320 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 639283001321 putative dimerization interface [polypeptide binding]; other site 639283001322 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 639283001323 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 639283001324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283001325 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283001326 active site 639283001327 catalytic tetrad [active] 639283001328 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 639283001329 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 639283001330 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 639283001331 dimer interface [polypeptide binding]; other site 639283001332 active site 639283001333 glycine-pyridoxal phosphate binding site [chemical binding]; other site 639283001334 folate binding site [chemical binding]; other site 639283001335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283001336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283001337 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 639283001338 putative dimerization interface [polypeptide binding]; other site 639283001339 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 639283001340 metal binding site [ion binding]; metal-binding site 639283001341 active site 639283001342 phosphoribulokinase; Provisional; Region: PRK15453 639283001343 active site 639283001344 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 639283001345 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 639283001346 TPP-binding site [chemical binding]; other site 639283001347 dimer interface [polypeptide binding]; other site 639283001348 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 639283001349 PYR/PP interface [polypeptide binding]; other site 639283001350 dimer interface [polypeptide binding]; other site 639283001351 TPP binding site [chemical binding]; other site 639283001352 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 639283001353 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 639283001354 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 639283001355 intersubunit interface [polypeptide binding]; other site 639283001356 active site 639283001357 zinc binding site [ion binding]; other site 639283001358 Na+ binding site [ion binding]; other site 639283001359 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 639283001360 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 639283001361 homodimer interface [polypeptide binding]; other site 639283001362 active site 639283001363 heterodimer interface [polypeptide binding]; other site 639283001364 catalytic residue [active] 639283001365 metal binding site [ion binding]; metal-binding site 639283001366 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 639283001367 multimerization interface [polypeptide binding]; other site 639283001368 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 639283001369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283001370 Walker A motif; other site 639283001371 ATP binding site [chemical binding]; other site 639283001372 Walker B motif; other site 639283001373 arginine finger; other site 639283001374 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 639283001375 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 639283001376 substrate binding site [chemical binding]; other site 639283001377 hexamer interface [polypeptide binding]; other site 639283001378 metal binding site [ion binding]; metal-binding site 639283001379 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 639283001380 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 639283001381 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 639283001382 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 639283001383 putative metal binding site [ion binding]; other site 639283001384 putative homodimer interface [polypeptide binding]; other site 639283001385 putative homotetramer interface [polypeptide binding]; other site 639283001386 putative homodimer-homodimer interface [polypeptide binding]; other site 639283001387 putative allosteric switch controlling residues; other site 639283001388 Mechanosensitive ion channel; Region: MS_channel; pfam00924 639283001389 multidrug resistance protein MdtN; Provisional; Region: PRK10476 639283001390 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283001391 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283001392 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 639283001393 Predicted membrane protein [Function unknown]; Region: COG1289 639283001394 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 639283001395 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 639283001396 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283001397 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283001398 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 639283001399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283001400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283001401 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 639283001402 putative effector binding pocket; other site 639283001403 putative dimerization interface [polypeptide binding]; other site 639283001404 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283001405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283001406 Walker A/P-loop; other site 639283001407 ATP binding site [chemical binding]; other site 639283001408 Q-loop/lid; other site 639283001409 ABC transporter signature motif; other site 639283001410 Walker B; other site 639283001411 D-loop; other site 639283001412 H-loop/switch region; other site 639283001413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001414 dimer interface [polypeptide binding]; other site 639283001415 conserved gate region; other site 639283001416 putative PBP binding loops; other site 639283001417 ABC-ATPase subunit interface; other site 639283001418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001419 dimer interface [polypeptide binding]; other site 639283001420 conserved gate region; other site 639283001421 putative PBP binding loops; other site 639283001422 ABC-ATPase subunit interface; other site 639283001423 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283001424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283001425 substrate binding pocket [chemical binding]; other site 639283001426 membrane-bound complex binding site; other site 639283001427 hinge residues; other site 639283001428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283001429 DNA-binding site [nucleotide binding]; DNA binding site 639283001430 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283001431 FCD domain; Region: FCD; pfam07729 639283001432 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 639283001433 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 639283001434 active site 639283001435 substrate binding site [chemical binding]; other site 639283001436 coenzyme B12 binding site [chemical binding]; other site 639283001437 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 639283001438 B12 binding site [chemical binding]; other site 639283001439 cobalt ligand [ion binding]; other site 639283001440 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 639283001441 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 639283001442 heterodimer interface [polypeptide binding]; other site 639283001443 substrate interaction site [chemical binding]; other site 639283001444 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 639283001445 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 639283001446 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 639283001447 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 639283001448 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 639283001449 carboxyltransferase (CT) interaction site; other site 639283001450 biotinylation site [posttranslational modification]; other site 639283001451 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 639283001452 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 639283001453 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 639283001454 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283001455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283001456 non-specific DNA binding site [nucleotide binding]; other site 639283001457 salt bridge; other site 639283001458 sequence-specific DNA binding site [nucleotide binding]; other site 639283001459 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 639283001460 Domain of unknown function (DUF955); Region: DUF955; pfam06114 639283001461 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 639283001462 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 639283001463 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 639283001464 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 639283001465 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 639283001466 active site 639283001467 FMN binding site [chemical binding]; other site 639283001468 substrate binding site [chemical binding]; other site 639283001469 3Fe-4S cluster binding site [ion binding]; other site 639283001470 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 639283001471 domain_subunit interface; other site 639283001472 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 639283001473 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 639283001474 putative active site [active] 639283001475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283001476 non-specific DNA binding site [nucleotide binding]; other site 639283001477 salt bridge; other site 639283001478 sequence-specific DNA binding site [nucleotide binding]; other site 639283001479 Cupin domain; Region: Cupin_2; pfam07883 639283001480 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 639283001481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 639283001482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283001483 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 639283001484 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 639283001485 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 639283001486 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 639283001487 homodimer interface [polypeptide binding]; other site 639283001488 NADP binding site [chemical binding]; other site 639283001489 substrate binding site [chemical binding]; other site 639283001490 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 639283001491 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 639283001492 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 639283001493 putative active site [active] 639283001494 putative substrate binding site [chemical binding]; other site 639283001495 putative cosubstrate binding site; other site 639283001496 catalytic site [active] 639283001497 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 639283001498 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 639283001499 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 639283001500 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 639283001501 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 639283001502 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 639283001503 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 639283001504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283001505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283001506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 639283001507 dimerization interface [polypeptide binding]; other site 639283001508 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 639283001509 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 639283001510 dimer interface [polypeptide binding]; other site 639283001511 active site 639283001512 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 639283001513 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 639283001514 beta-galactosidase; Region: BGL; TIGR03356 639283001515 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 639283001516 fructuronate transporter; Provisional; Region: PRK10034; cl15264 639283001517 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 639283001518 malonyl-CoA synthase; Validated; Region: PRK07514 639283001519 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 639283001520 acyl-activating enzyme (AAE) consensus motif; other site 639283001521 active site 639283001522 AMP binding site [chemical binding]; other site 639283001523 CoA binding site [chemical binding]; other site 639283001524 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 639283001525 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 639283001526 DNA binding site [nucleotide binding] 639283001527 active site 639283001528 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 639283001529 putative homodimer interface [polypeptide binding]; other site 639283001530 putative homotetramer interface [polypeptide binding]; other site 639283001531 putative allosteric switch controlling residues; other site 639283001532 putative metal binding site [ion binding]; other site 639283001533 putative homodimer-homodimer interface [polypeptide binding]; other site 639283001534 YHS domain; Region: YHS; pfam04945 639283001535 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 639283001536 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 639283001537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 639283001538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283001539 motif II; other site 639283001540 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 639283001541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283001542 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 639283001543 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 639283001544 putative acyl-acceptor binding pocket; other site 639283001545 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 639283001546 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283001547 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 639283001548 active site 639283001549 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 639283001550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283001551 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283001552 active site 639283001553 catalytic tetrad [active] 639283001554 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 639283001555 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 639283001556 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 639283001557 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 639283001558 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 639283001559 dimer interface [polypeptide binding]; other site 639283001560 active site 639283001561 acyl-CoA synthetase; Validated; Region: PRK07638 639283001562 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 639283001563 AMP binding site [chemical binding]; other site 639283001564 active site 639283001565 acyl-activating enzyme (AAE) consensus motif; other site 639283001566 CoA binding site [chemical binding]; other site 639283001567 BioY family; Region: BioY; pfam02632 639283001568 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 639283001569 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 639283001570 Walker A/P-loop; other site 639283001571 ATP binding site [chemical binding]; other site 639283001572 Q-loop/lid; other site 639283001573 ABC transporter signature motif; other site 639283001574 Walker B; other site 639283001575 D-loop; other site 639283001576 H-loop/switch region; other site 639283001577 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283001578 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283001579 active site 639283001580 catalytic tetrad [active] 639283001581 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 639283001582 putative acetyltransferase; Provisional; Region: PRK03624 639283001583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283001584 Coenzyme A binding pocket [chemical binding]; other site 639283001585 quinolinate synthetase; Provisional; Region: PRK09375 639283001586 L-aspartate oxidase; Provisional; Region: PRK07512 639283001587 L-aspartate oxidase; Provisional; Region: PRK06175 639283001588 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 639283001589 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 639283001590 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 639283001591 dimerization interface [polypeptide binding]; other site 639283001592 active site 639283001593 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 639283001594 hydroxyglutarate oxidase; Provisional; Region: PRK11728 639283001595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283001596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283001597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283001598 dimerization interface [polypeptide binding]; other site 639283001599 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283001600 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283001601 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283001602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283001603 Walker A/P-loop; other site 639283001604 ATP binding site [chemical binding]; other site 639283001605 Q-loop/lid; other site 639283001606 ABC transporter signature motif; other site 639283001607 Walker B; other site 639283001608 D-loop; other site 639283001609 H-loop/switch region; other site 639283001610 TOBE domain; Region: TOBE_2; pfam08402 639283001611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001612 putative PBP binding loops; other site 639283001613 dimer interface [polypeptide binding]; other site 639283001614 ABC-ATPase subunit interface; other site 639283001615 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283001616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001617 dimer interface [polypeptide binding]; other site 639283001618 conserved gate region; other site 639283001619 putative PBP binding loops; other site 639283001620 ABC-ATPase subunit interface; other site 639283001621 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 639283001622 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 639283001623 tetrameric interface [polypeptide binding]; other site 639283001624 NAD binding site [chemical binding]; other site 639283001625 catalytic residues [active] 639283001626 substrate binding site [chemical binding]; other site 639283001627 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283001628 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283001629 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283001630 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 639283001631 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 639283001632 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 639283001633 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 639283001634 Walker A/P-loop; other site 639283001635 ATP binding site [chemical binding]; other site 639283001636 Q-loop/lid; other site 639283001637 ABC transporter signature motif; other site 639283001638 Walker B; other site 639283001639 D-loop; other site 639283001640 H-loop/switch region; other site 639283001641 TOBE domain; Region: TOBE; pfam03459 639283001642 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 639283001643 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 639283001644 Walker A/P-loop; other site 639283001645 ATP binding site [chemical binding]; other site 639283001646 Q-loop/lid; other site 639283001647 ABC transporter signature motif; other site 639283001648 Walker B; other site 639283001649 D-loop; other site 639283001650 H-loop/switch region; other site 639283001651 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 639283001652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001653 dimer interface [polypeptide binding]; other site 639283001654 conserved gate region; other site 639283001655 putative PBP binding loops; other site 639283001656 ABC-ATPase subunit interface; other site 639283001657 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283001658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001659 dimer interface [polypeptide binding]; other site 639283001660 conserved gate region; other site 639283001661 ABC-ATPase subunit interface; other site 639283001662 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 639283001663 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 639283001664 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283001665 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283001666 active site 639283001667 catalytic tetrad [active] 639283001668 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283001669 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283001670 DNA-binding site [nucleotide binding]; DNA binding site 639283001671 FCD domain; Region: FCD; pfam07729 639283001672 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 639283001673 TAP-like protein; Region: Abhydrolase_4; pfam08386 639283001674 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 639283001675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001676 dimer interface [polypeptide binding]; other site 639283001677 conserved gate region; other site 639283001678 putative PBP binding loops; other site 639283001679 ABC-ATPase subunit interface; other site 639283001680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001681 dimer interface [polypeptide binding]; other site 639283001682 conserved gate region; other site 639283001683 putative PBP binding loops; other site 639283001684 ABC-ATPase subunit interface; other site 639283001685 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283001686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283001687 Walker A/P-loop; other site 639283001688 ATP binding site [chemical binding]; other site 639283001689 Q-loop/lid; other site 639283001690 ABC transporter signature motif; other site 639283001691 Walker B; other site 639283001692 D-loop; other site 639283001693 H-loop/switch region; other site 639283001694 TOBE domain; Region: TOBE_2; pfam08402 639283001695 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 639283001696 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283001697 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 639283001698 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 639283001699 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 639283001700 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 639283001701 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 639283001702 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 639283001703 DNA binding residues [nucleotide binding] 639283001704 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 639283001705 GAF domain; Region: GAF; pfam01590 639283001706 choline dehydrogenase; Validated; Region: PRK02106 639283001707 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 639283001708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283001709 active site 639283001710 phosphorylation site [posttranslational modification] 639283001711 dimerization interface [polypeptide binding]; other site 639283001712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283001713 DNA binding site [nucleotide binding] 639283001714 Cupin; Region: Cupin_6; pfam12852 639283001715 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 639283001716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283001717 short chain dehydrogenase; Provisional; Region: PRK06180 639283001718 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 639283001719 NADP binding site [chemical binding]; other site 639283001720 active site 639283001721 steroid binding site; other site 639283001722 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 639283001723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283001724 DNA binding residues [nucleotide binding] 639283001725 dimerization interface [polypeptide binding]; other site 639283001726 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 639283001727 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283001728 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 639283001729 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 639283001730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283001731 catalytic residue [active] 639283001732 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 639283001733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283001734 putative DNA binding site [nucleotide binding]; other site 639283001735 putative Zn2+ binding site [ion binding]; other site 639283001736 AsnC family; Region: AsnC_trans_reg; pfam01037 639283001737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283001738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283001739 DNA binding site [nucleotide binding] 639283001740 Predicted ATPase [General function prediction only]; Region: COG3903 639283001741 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283001742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001743 dimer interface [polypeptide binding]; other site 639283001744 conserved gate region; other site 639283001745 putative PBP binding loops; other site 639283001746 ABC-ATPase subunit interface; other site 639283001747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001748 dimer interface [polypeptide binding]; other site 639283001749 conserved gate region; other site 639283001750 putative PBP binding loops; other site 639283001751 ABC-ATPase subunit interface; other site 639283001752 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 639283001753 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 639283001754 Predicted membrane protein [Function unknown]; Region: COG2149 639283001755 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 639283001756 substrate binding site [chemical binding]; other site 639283001757 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 639283001758 Protein of unknown function (DUF521); Region: DUF521; pfam04412 639283001759 substrate binding site [chemical binding]; other site 639283001760 ligand binding site [chemical binding]; other site 639283001761 DctM-like transporters; Region: DctM; pfam06808 639283001762 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 639283001763 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 639283001764 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 639283001765 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 639283001766 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 639283001767 Sulfatase; Region: Sulfatase; cl17466 639283001768 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 639283001769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283001770 DNA-binding site [nucleotide binding]; DNA binding site 639283001771 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 639283001772 Uncharacterized conserved protein [Function unknown]; Region: COG5276 639283001773 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 639283001774 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 639283001775 mechanosensitive channel MscS; Provisional; Region: PRK10334 639283001776 Mechanosensitive ion channel; Region: MS_channel; pfam00924 639283001777 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 639283001778 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 639283001779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283001780 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 639283001781 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 639283001782 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 639283001783 Helix-turn-helix domain; Region: HTH_18; pfam12833 639283001784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283001785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283001786 DNA binding site [nucleotide binding] 639283001787 Predicted integral membrane protein [Function unknown]; Region: COG5616 639283001788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283001789 binding surface 639283001790 TPR motif; other site 639283001791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283001792 binding surface 639283001793 TPR motif; other site 639283001794 Protein of unknown function (DUF995); Region: DUF995; pfam06191 639283001795 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 639283001796 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 639283001797 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 639283001798 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 639283001799 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 639283001800 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 639283001801 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 639283001802 active site 639283001803 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 639283001804 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 639283001805 NAD binding site [chemical binding]; other site 639283001806 homodimer interface [polypeptide binding]; other site 639283001807 active site 639283001808 substrate binding site [chemical binding]; other site 639283001809 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 639283001810 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 639283001811 NAD binding site [chemical binding]; other site 639283001812 putative substrate binding site 2 [chemical binding]; other site 639283001813 putative substrate binding site 1 [chemical binding]; other site 639283001814 active site 639283001815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283001816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283001817 dimer interface [polypeptide binding]; other site 639283001818 phosphorylation site [posttranslational modification] 639283001819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283001820 ATP binding site [chemical binding]; other site 639283001821 Mg2+ binding site [ion binding]; other site 639283001822 G-X-G motif; other site 639283001823 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283001824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283001825 active site 639283001826 phosphorylation site [posttranslational modification] 639283001827 intermolecular recognition site; other site 639283001828 dimerization interface [polypeptide binding]; other site 639283001829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283001830 DNA binding site [nucleotide binding] 639283001831 PAS fold; Region: PAS_7; pfam12860 639283001832 PAS fold; Region: PAS_7; pfam12860 639283001833 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283001834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283001835 metal binding site [ion binding]; metal-binding site 639283001836 active site 639283001837 I-site; other site 639283001838 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283001839 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 639283001840 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 639283001841 Cu(I) binding site [ion binding]; other site 639283001842 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 639283001843 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 639283001844 DXD motif; other site 639283001845 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283001846 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283001847 substrate binding pocket [chemical binding]; other site 639283001848 membrane-bound complex binding site; other site 639283001849 hinge residues; other site 639283001850 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 639283001851 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 639283001852 active site 639283001853 nucleotide binding site [chemical binding]; other site 639283001854 HIGH motif; other site 639283001855 KMSKS motif; other site 639283001856 thiamine pyrophosphate protein; Validated; Region: PRK08199 639283001857 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 639283001858 PYR/PP interface [polypeptide binding]; other site 639283001859 dimer interface [polypeptide binding]; other site 639283001860 TPP binding site [chemical binding]; other site 639283001861 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 639283001862 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 639283001863 TPP-binding site [chemical binding]; other site 639283001864 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 639283001865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283001866 Mg2+ binding site [ion binding]; other site 639283001867 G-X-G motif; other site 639283001868 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 639283001869 anchoring element; other site 639283001870 dimer interface [polypeptide binding]; other site 639283001871 ATP binding site [chemical binding]; other site 639283001872 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 639283001873 active site 639283001874 putative metal-binding site [ion binding]; other site 639283001875 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 639283001876 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 639283001877 recombination protein F; Reviewed; Region: recF; PRK00064 639283001878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283001879 Walker A/P-loop; other site 639283001880 ATP binding site [chemical binding]; other site 639283001881 Q-loop/lid; other site 639283001882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283001883 ABC transporter signature motif; other site 639283001884 Walker B; other site 639283001885 D-loop; other site 639283001886 H-loop/switch region; other site 639283001887 DNA polymerase III subunit beta; Validated; Region: PRK05643 639283001888 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 639283001889 putative DNA binding surface [nucleotide binding]; other site 639283001890 dimer interface [polypeptide binding]; other site 639283001891 beta-clamp/clamp loader binding surface; other site 639283001892 beta-clamp/translesion DNA polymerase binding surface; other site 639283001893 DnaA N-terminal domain; Region: DnaA_N; pfam11638 639283001894 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 639283001895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283001896 Walker A motif; other site 639283001897 ATP binding site [chemical binding]; other site 639283001898 Walker B motif; other site 639283001899 arginine finger; other site 639283001900 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 639283001901 DnaA box-binding interface [nucleotide binding]; other site 639283001902 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 639283001903 enoyl-CoA hydratase; Provisional; Region: PRK05862 639283001904 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 639283001905 substrate binding site [chemical binding]; other site 639283001906 oxyanion hole (OAH) forming residues; other site 639283001907 trimer interface [polypeptide binding]; other site 639283001908 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 639283001909 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 639283001910 DNA binding site [nucleotide binding] 639283001911 catalytic residue [active] 639283001912 H2TH interface [polypeptide binding]; other site 639283001913 putative catalytic residues [active] 639283001914 turnover-facilitating residue; other site 639283001915 intercalation triad [nucleotide binding]; other site 639283001916 8OG recognition residue [nucleotide binding]; other site 639283001917 putative reading head residues; other site 639283001918 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 639283001919 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 639283001920 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 639283001921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283001922 motif II; other site 639283001923 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 639283001924 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 639283001925 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 639283001926 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 639283001927 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 639283001928 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 639283001929 Subunit I/III interface [polypeptide binding]; other site 639283001930 D-pathway; other site 639283001931 Subunit I/VIIc interface [polypeptide binding]; other site 639283001932 Subunit I/IV interface [polypeptide binding]; other site 639283001933 Subunit I/II interface [polypeptide binding]; other site 639283001934 Low-spin heme (heme a) binding site [chemical binding]; other site 639283001935 Subunit I/VIIa interface [polypeptide binding]; other site 639283001936 Subunit I/VIa interface [polypeptide binding]; other site 639283001937 Dimer interface; other site 639283001938 Putative water exit pathway; other site 639283001939 Binuclear center (heme a3/CuB) [ion binding]; other site 639283001940 K-pathway; other site 639283001941 Subunit I/Vb interface [polypeptide binding]; other site 639283001942 Putative proton exit pathway; other site 639283001943 Subunit I/VIb interface; other site 639283001944 Subunit I/VIc interface [polypeptide binding]; other site 639283001945 Electron transfer pathway; other site 639283001946 Subunit I/VIIIb interface [polypeptide binding]; other site 639283001947 Subunit I/VIIb interface [polypeptide binding]; other site 639283001948 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 639283001949 UbiA prenyltransferase family; Region: UbiA; pfam01040 639283001950 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442 639283001951 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 639283001952 Subunit III/VIIa interface [polypeptide binding]; other site 639283001953 Phospholipid binding site [chemical binding]; other site 639283001954 Subunit I/III interface [polypeptide binding]; other site 639283001955 Subunit III/VIb interface [polypeptide binding]; other site 639283001956 Subunit III/VIa interface; other site 639283001957 Subunit III/Vb interface [polypeptide binding]; other site 639283001958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 639283001959 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 639283001960 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 639283001961 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 639283001962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283001963 catalytic residue [active] 639283001964 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 639283001965 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 639283001966 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 639283001967 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 639283001968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 639283001969 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 639283001970 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 639283001971 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 639283001972 heme binding site [chemical binding]; other site 639283001973 ferroxidase pore; other site 639283001974 ferroxidase diiron center [ion binding]; other site 639283001975 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 639283001976 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283001977 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 639283001978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283001979 dimer interface [polypeptide binding]; other site 639283001980 conserved gate region; other site 639283001981 putative PBP binding loops; other site 639283001982 ABC-ATPase subunit interface; other site 639283001983 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 639283001984 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 639283001985 acyl-activating enzyme (AAE) consensus motif; other site 639283001986 putative AMP binding site [chemical binding]; other site 639283001987 putative active site [active] 639283001988 putative CoA binding site [chemical binding]; other site 639283001989 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 639283001990 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 639283001991 LytTr DNA-binding domain; Region: LytTR; smart00850 639283001992 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 639283001993 Predicted membrane protein [Function unknown]; Region: COG1238 639283001994 multiple promoter invertase; Provisional; Region: mpi; PRK13413 639283001995 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 639283001996 catalytic residues [active] 639283001997 catalytic nucleophile [active] 639283001998 Presynaptic Site I dimer interface [polypeptide binding]; other site 639283001999 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 639283002000 Synaptic Flat tetramer interface [polypeptide binding]; other site 639283002001 Synaptic Site I dimer interface [polypeptide binding]; other site 639283002002 DNA binding site [nucleotide binding] 639283002003 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 639283002004 DNA-binding interface [nucleotide binding]; DNA binding site 639283002005 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 639283002006 Methyltransferase domain; Region: Methyltransf_26; pfam13659 639283002007 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 639283002008 ParB-like nuclease domain; Region: ParB; smart00470 639283002009 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 639283002010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 639283002011 active site 639283002012 DNA binding site [nucleotide binding] 639283002013 Int/Topo IB signature motif; other site 639283002014 PAS domain S-box; Region: sensory_box; TIGR00229 639283002015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283002016 putative active site [active] 639283002017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283002018 dimer interface [polypeptide binding]; other site 639283002019 phosphorylation site [posttranslational modification] 639283002020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283002021 ATP binding site [chemical binding]; other site 639283002022 Mg2+ binding site [ion binding]; other site 639283002023 G-X-G motif; other site 639283002024 Phasin protein; Region: Phasin_2; cl11491 639283002025 phasin; Region: phasin_2; TIGR01985 639283002026 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 639283002027 oligomerisation interface [polypeptide binding]; other site 639283002028 mobile loop; other site 639283002029 roof hairpin; other site 639283002030 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 639283002031 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 639283002032 ring oligomerisation interface [polypeptide binding]; other site 639283002033 ATP/Mg binding site [chemical binding]; other site 639283002034 stacking interactions; other site 639283002035 hinge regions; other site 639283002036 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 639283002037 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 639283002038 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 639283002039 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 639283002040 RNA/DNA hybrid binding site [nucleotide binding]; other site 639283002041 active site 639283002042 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 639283002043 putative hydrophobic ligand binding site [chemical binding]; other site 639283002044 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 639283002045 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 639283002046 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 639283002047 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 639283002048 Fe-S cluster binding site [ion binding]; other site 639283002049 active site 639283002050 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 639283002051 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 639283002052 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 639283002053 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 639283002054 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 639283002055 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 639283002056 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 639283002057 Walker A/P-loop; other site 639283002058 ATP binding site [chemical binding]; other site 639283002059 Q-loop/lid; other site 639283002060 ABC transporter signature motif; other site 639283002061 Walker B; other site 639283002062 D-loop; other site 639283002063 H-loop/switch region; other site 639283002064 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 639283002065 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 639283002066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002067 dimer interface [polypeptide binding]; other site 639283002068 conserved gate region; other site 639283002069 ABC-ATPase subunit interface; other site 639283002070 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 639283002071 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 639283002072 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 639283002073 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 639283002074 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 639283002075 Cl- selectivity filter; other site 639283002076 Cl- binding residues [ion binding]; other site 639283002077 pore gating glutamate residue; other site 639283002078 dimer interface [polypeptide binding]; other site 639283002079 H+/Cl- coupling transport residue; other site 639283002080 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 639283002081 NMT1/THI5 like; Region: NMT1; pfam09084 639283002082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 639283002083 membrane-bound complex binding site; other site 639283002084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 639283002085 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 639283002086 PAS domain S-box; Region: sensory_box; TIGR00229 639283002087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283002088 putative active site [active] 639283002089 heme pocket [chemical binding]; other site 639283002090 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283002091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283002092 metal binding site [ion binding]; metal-binding site 639283002093 active site 639283002094 I-site; other site 639283002095 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283002096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002097 dimer interface [polypeptide binding]; other site 639283002098 conserved gate region; other site 639283002099 putative PBP binding loops; other site 639283002100 ABC-ATPase subunit interface; other site 639283002101 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 639283002102 Ligand Binding Site [chemical binding]; other site 639283002103 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 639283002104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 639283002105 DNA-binding site [nucleotide binding]; DNA binding site 639283002106 RNA-binding motif; other site 639283002107 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 639283002108 hypothetical protein; Region: PHA00684 639283002109 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 639283002110 amidase; Provisional; Region: PRK09201 639283002111 Amidase; Region: Amidase; cl11426 639283002112 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 639283002113 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 639283002114 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 639283002115 Cytochrome c553 [Energy production and conversion]; Region: COG2863 639283002116 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 639283002117 putative substrate binding pocket [chemical binding]; other site 639283002118 AC domain interface; other site 639283002119 catalytic triad [active] 639283002120 AB domain interface; other site 639283002121 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 639283002122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283002123 active site 639283002124 phosphorylation site [posttranslational modification] 639283002125 intermolecular recognition site; other site 639283002126 dimerization interface [polypeptide binding]; other site 639283002127 membrane ATPase/protein kinase; Provisional; Region: PRK09435 639283002128 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 639283002129 Walker A; other site 639283002130 CsbD-like; Region: CsbD; cl17424 639283002131 aminotransferase; Provisional; Region: PRK13356 639283002132 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 639283002133 homodimer interface [polypeptide binding]; other site 639283002134 substrate-cofactor binding pocket; other site 639283002135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283002136 catalytic residue [active] 639283002137 hypothetical protein; Validated; Region: PRK09104 639283002138 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 639283002139 metal binding site [ion binding]; metal-binding site 639283002140 putative dimer interface [polypeptide binding]; other site 639283002141 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 639283002142 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 639283002143 dihydropteroate synthase; Region: DHPS; TIGR01496 639283002144 substrate binding pocket [chemical binding]; other site 639283002145 dimer interface [polypeptide binding]; other site 639283002146 inhibitor binding site; inhibition site 639283002147 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 639283002148 catalytic center binding site [active] 639283002149 ATP binding site [chemical binding]; other site 639283002150 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 639283002151 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 639283002152 Cl binding site [ion binding]; other site 639283002153 oligomer interface [polypeptide binding]; other site 639283002154 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 639283002155 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 639283002156 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 639283002157 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 639283002158 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 639283002159 methionine sulfoxide reductase B; Provisional; Region: PRK00222 639283002160 SelR domain; Region: SelR; pfam01641 639283002161 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 639283002162 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 639283002163 DnaA box-binding interface [nucleotide binding]; other site 639283002164 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 639283002165 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283002166 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 639283002167 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 639283002168 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 639283002169 Predicted integral membrane protein [Function unknown]; Region: COG5436 639283002170 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 639283002171 Transglycosylase; Region: Transgly; pfam00912 639283002172 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 639283002173 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 639283002174 hypothetical protein; Provisional; Region: PRK05170 639283002175 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 639283002176 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 639283002177 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 639283002178 phosphate binding site [ion binding]; other site 639283002179 L-lactate permease; Region: Lactate_perm; cl00701 639283002180 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 639283002181 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 639283002182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283002183 DNA-binding site [nucleotide binding]; DNA binding site 639283002184 FCD domain; Region: FCD; pfam07729 639283002185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283002186 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 639283002187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283002188 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283002189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283002190 EamA-like transporter family; Region: EamA; pfam00892 639283002191 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 639283002192 trimer interface [polypeptide binding]; other site 639283002193 active site 639283002194 Predicted flavoprotein [General function prediction only]; Region: COG0431 639283002195 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 639283002196 Beta-lactamase; Region: Beta-lactamase; pfam00144 639283002197 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 639283002198 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 639283002199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283002200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283002201 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 639283002202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 639283002203 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 639283002204 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 639283002205 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 639283002206 Uncharacterized conserved protein [Function unknown]; Region: COG5323 639283002207 Terminase-like family; Region: Terminase_6; pfam03237 639283002208 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 639283002209 putative active site [active] 639283002210 putative catalytic site [active] 639283002211 putative Mg binding site IVb [ion binding]; other site 639283002212 putative phosphate binding site [ion binding]; other site 639283002213 putative DNA binding site [nucleotide binding]; other site 639283002214 putative Mg binding site IVa [ion binding]; other site 639283002215 Phage-related protein [Function unknown]; Region: COG4695 639283002216 Phage portal protein; Region: Phage_portal; pfam04860 639283002217 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 639283002218 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 639283002219 Phage capsid family; Region: Phage_capsid; pfam05065 639283002220 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 639283002221 cleavage site 639283002222 active site 639283002223 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 639283002224 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 639283002225 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 639283002226 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 639283002227 Phage major tail protein 2; Region: Phage_tail_2; cl11463 639283002228 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 639283002229 phage conserved hypothetical protein; Region: phage_TIGR02216 639283002230 Phage-related minor tail protein [Function unknown]; Region: COG5281 639283002231 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 639283002232 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 639283002233 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 639283002234 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 639283002235 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 639283002236 NlpC/P60 family; Region: NLPC_P60; cl17555 639283002237 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 639283002238 Putative phage tail protein; Region: Phage-tail_3; pfam13550 639283002239 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 639283002240 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 639283002241 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 639283002242 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 639283002243 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 639283002244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283002245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283002246 active site 639283002247 phosphorylation site [posttranslational modification] 639283002248 intermolecular recognition site; other site 639283002249 dimerization interface [polypeptide binding]; other site 639283002250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283002251 DNA binding site [nucleotide binding] 639283002252 sensor protein PhoQ; Provisional; Region: PRK10815 639283002253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283002254 ATP binding site [chemical binding]; other site 639283002255 Mg2+ binding site [ion binding]; other site 639283002256 G-X-G motif; other site 639283002257 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 639283002258 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 639283002259 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 639283002260 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 639283002261 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 639283002262 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 639283002263 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 639283002264 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 639283002265 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 639283002266 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 639283002267 protein binding site [polypeptide binding]; other site 639283002268 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 639283002269 protein binding site [polypeptide binding]; other site 639283002270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283002271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283002272 active site 639283002273 phosphorylation site [posttranslational modification] 639283002274 intermolecular recognition site; other site 639283002275 dimerization interface [polypeptide binding]; other site 639283002276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283002277 DNA binding site [nucleotide binding] 639283002278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 639283002279 dimerization interface [polypeptide binding]; other site 639283002280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283002281 dimer interface [polypeptide binding]; other site 639283002282 phosphorylation site [posttranslational modification] 639283002283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283002284 ATP binding site [chemical binding]; other site 639283002285 Mg2+ binding site [ion binding]; other site 639283002286 G-X-G motif; other site 639283002287 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 639283002288 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 639283002289 metal binding triad; other site 639283002290 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 639283002291 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 639283002292 metal binding triad; other site 639283002293 hydroxyglutarate oxidase; Provisional; Region: PRK11728 639283002294 Predicted dehydrogenase [General function prediction only]; Region: COG0579 639283002295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283002296 PAS fold; Region: PAS_3; pfam08447 639283002297 putative active site [active] 639283002298 heme pocket [chemical binding]; other site 639283002299 PAS fold; Region: PAS_7; pfam12860 639283002300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283002301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283002302 dimer interface [polypeptide binding]; other site 639283002303 phosphorylation site [posttranslational modification] 639283002304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283002305 ATP binding site [chemical binding]; other site 639283002306 Mg2+ binding site [ion binding]; other site 639283002307 G-X-G motif; other site 639283002308 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 639283002309 PAS fold; Region: PAS_4; pfam08448 639283002310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283002311 putative active site [active] 639283002312 heme pocket [chemical binding]; other site 639283002313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283002314 PAS fold; Region: PAS_3; pfam08447 639283002315 putative active site [active] 639283002316 heme pocket [chemical binding]; other site 639283002317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283002318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283002319 metal binding site [ion binding]; metal-binding site 639283002320 active site 639283002321 I-site; other site 639283002322 aminopeptidase N; Provisional; Region: pepN; PRK14015 639283002323 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 639283002324 active site 639283002325 Zn binding site [ion binding]; other site 639283002326 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 639283002327 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 639283002328 homooctamer interface [polypeptide binding]; other site 639283002329 active site 639283002330 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 639283002331 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 639283002332 ATP-grasp domain; Region: ATP-grasp_4; cl17255 639283002333 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 639283002334 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 639283002335 active site 639283002336 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 639283002337 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 639283002338 ATP-grasp domain; Region: ATP-grasp_4; cl17255 639283002339 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 639283002340 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 639283002341 trimer interface I [polypeptide binding]; other site 639283002342 putative substrate binding pocket [chemical binding]; other site 639283002343 trimer interface II [polypeptide binding]; other site 639283002344 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 639283002345 ATP-grasp domain; Region: ATP-grasp_4; cl17255 639283002346 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 639283002347 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 639283002348 NAD(P) binding pocket [chemical binding]; other site 639283002349 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 639283002350 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 639283002351 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 639283002352 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 639283002353 aromatic arch; other site 639283002354 DCoH dimer interaction site [polypeptide binding]; other site 639283002355 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 639283002356 DCoH tetramer interaction site [polypeptide binding]; other site 639283002357 substrate binding site [chemical binding]; other site 639283002358 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 639283002359 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 639283002360 molybdopterin cofactor binding site; other site 639283002361 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 639283002362 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283002363 active site 639283002364 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 639283002365 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 639283002366 FTR, proximal lobe; Region: FTR_C; pfam02741 639283002367 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 639283002368 domain_subunit interface; other site 639283002369 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 639283002370 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 639283002371 MgtE intracellular N domain; Region: MgtE_N; pfam03448 639283002372 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 639283002373 Divalent cation transporter; Region: MgtE; pfam01769 639283002374 hypothetical protein; Provisional; Region: PRK02227 639283002375 Protein of unknown function (DUF447); Region: DUF447; pfam04289 639283002376 dihydropteroate synthase-related protein; Region: TIGR00284 639283002377 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 639283002378 substrate binding pocket [chemical binding]; other site 639283002379 dimer interface [polypeptide binding]; other site 639283002380 inhibitor binding site; inhibition site 639283002381 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 639283002382 Flavoprotein; Region: Flavoprotein; pfam02441 639283002383 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 639283002384 nucleotide binding site [chemical binding]; other site 639283002385 substrate binding site [chemical binding]; other site 639283002386 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 639283002387 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 639283002388 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 639283002389 ABC transporter ATPase component; Reviewed; Region: PRK11147 639283002390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 639283002391 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 639283002392 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 639283002393 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 639283002394 FAD binding domain; Region: FAD_binding_4; pfam01565 639283002395 tonB-system energizer ExbB; Region: exbB; TIGR02797 639283002396 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 639283002397 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 639283002398 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 639283002399 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 639283002400 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 639283002401 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 639283002402 catalytic residues [active] 639283002403 catalytic nucleophile [active] 639283002404 Recombinase; Region: Recombinase; pfam07508 639283002405 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 639283002406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283002407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283002408 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 639283002409 classical (c) SDRs; Region: SDR_c; cd05233 639283002410 NAD(P) binding site [chemical binding]; other site 639283002411 active site 639283002412 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 639283002413 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 639283002414 putative di-iron ligands [ion binding]; other site 639283002415 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 639283002416 PAS domain; Region: PAS_9; pfam13426 639283002417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 639283002418 Histidine kinase; Region: HisKA_2; pfam07568 639283002419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283002420 ATP binding site [chemical binding]; other site 639283002421 Mg2+ binding site [ion binding]; other site 639283002422 G-X-G motif; other site 639283002423 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 639283002424 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 639283002425 Walker A/P-loop; other site 639283002426 ATP binding site [chemical binding]; other site 639283002427 Q-loop/lid; other site 639283002428 ABC transporter signature motif; other site 639283002429 Walker B; other site 639283002430 D-loop; other site 639283002431 H-loop/switch region; other site 639283002432 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 639283002433 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 639283002434 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 639283002435 Walker A/P-loop; other site 639283002436 ATP binding site [chemical binding]; other site 639283002437 Q-loop/lid; other site 639283002438 ABC transporter signature motif; other site 639283002439 Walker B; other site 639283002440 D-loop; other site 639283002441 H-loop/switch region; other site 639283002442 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 639283002443 dipeptide transporter; Provisional; Region: PRK10913 639283002444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002445 ABC-ATPase subunit interface; other site 639283002446 putative PBP binding loops; other site 639283002447 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 639283002448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002449 dimer interface [polypeptide binding]; other site 639283002450 conserved gate region; other site 639283002451 putative PBP binding loops; other site 639283002452 ABC-ATPase subunit interface; other site 639283002453 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 639283002454 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 639283002455 peptide binding site [polypeptide binding]; other site 639283002456 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 639283002457 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 639283002458 FAD binding site [chemical binding]; other site 639283002459 substrate binding pocket [chemical binding]; other site 639283002460 catalytic base [active] 639283002461 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 639283002462 active site 639283002463 dimer interfaces [polypeptide binding]; other site 639283002464 catalytic residues [active] 639283002465 Rrf2 family protein; Region: rrf2_super; TIGR00738 639283002466 Transcriptional regulator; Region: Rrf2; pfam02082 639283002467 AAA domain; Region: AAA_22; pfam13401 639283002468 AAA domain; Region: AAA_30; pfam13604 639283002469 Helicase; Region: Herpes_Helicase; pfam02689 639283002470 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 639283002471 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 639283002472 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 639283002473 tetramerization interface [polypeptide binding]; other site 639283002474 NAD(P) binding site [chemical binding]; other site 639283002475 catalytic residues [active] 639283002476 MgtC family; Region: MgtC; pfam02308 639283002477 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 639283002478 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 639283002479 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 639283002480 Predicted acetyltransferase [General function prediction only]; Region: COG2388 639283002481 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 639283002482 putative FMN binding site [chemical binding]; other site 639283002483 malate synthase G; Provisional; Region: PRK02999 639283002484 active site 639283002485 isocitrate lyase; Provisional; Region: PRK15063 639283002486 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 639283002487 tetramer interface [polypeptide binding]; other site 639283002488 active site 639283002489 Mg2+/Mn2+ binding site [ion binding]; other site 639283002490 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283002491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283002492 non-specific DNA binding site [nucleotide binding]; other site 639283002493 salt bridge; other site 639283002494 sequence-specific DNA binding site [nucleotide binding]; other site 639283002495 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 639283002496 Domain of unknown function (DUF955); Region: DUF955; pfam06114 639283002497 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 639283002498 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 639283002499 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 639283002500 putative DNA binding site [nucleotide binding]; other site 639283002501 putative homodimer interface [polypeptide binding]; other site 639283002502 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 639283002503 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 639283002504 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 639283002505 active site 639283002506 DNA binding site [nucleotide binding] 639283002507 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 639283002508 DNA binding site [nucleotide binding] 639283002509 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 639283002510 nucleotide binding site [chemical binding]; other site 639283002511 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 639283002512 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 639283002513 putative DNA binding site [nucleotide binding]; other site 639283002514 putative homodimer interface [polypeptide binding]; other site 639283002515 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 639283002516 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 639283002517 Cl- selectivity filter; other site 639283002518 Cl- binding residues [ion binding]; other site 639283002519 pore gating glutamate residue; other site 639283002520 dimer interface [polypeptide binding]; other site 639283002521 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 639283002522 putative S-transferase; Provisional; Region: PRK11752 639283002523 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 639283002524 C-terminal domain interface [polypeptide binding]; other site 639283002525 GSH binding site (G-site) [chemical binding]; other site 639283002526 dimer interface [polypeptide binding]; other site 639283002527 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 639283002528 dimer interface [polypeptide binding]; other site 639283002529 N-terminal domain interface [polypeptide binding]; other site 639283002530 active site 639283002531 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 639283002532 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 639283002533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283002534 NAD(P) binding site [chemical binding]; other site 639283002535 active site 639283002536 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 639283002537 Isochorismatase family; Region: Isochorismatase; pfam00857 639283002538 catalytic triad [active] 639283002539 metal binding site [ion binding]; metal-binding site 639283002540 conserved cis-peptide bond; other site 639283002541 methionine sulfoxide reductase B; Provisional; Region: PRK00222 639283002542 SelR domain; Region: SelR; pfam01641 639283002543 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 639283002544 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 639283002545 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 639283002546 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 639283002547 catalytic residues [active] 639283002548 methionine sulfoxide reductase A; Provisional; Region: PRK13014 639283002549 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 639283002550 Surface antigen; Region: Bac_surface_Ag; pfam01103 639283002551 Family of unknown function (DUF490); Region: DUF490; pfam04357 639283002552 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 639283002553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283002554 motif II; other site 639283002555 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 639283002556 MarR family; Region: MarR_2; pfam12802 639283002557 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 639283002558 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 639283002559 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 639283002560 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 639283002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002562 conserved gate region; other site 639283002563 dimer interface [polypeptide binding]; other site 639283002564 putative PBP binding loops; other site 639283002565 ABC-ATPase subunit interface; other site 639283002566 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002568 dimer interface [polypeptide binding]; other site 639283002569 conserved gate region; other site 639283002570 putative PBP binding loops; other site 639283002571 ABC-ATPase subunit interface; other site 639283002572 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 639283002573 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 639283002574 Walker A/P-loop; other site 639283002575 ATP binding site [chemical binding]; other site 639283002576 Q-loop/lid; other site 639283002577 ABC transporter signature motif; other site 639283002578 Walker B; other site 639283002579 D-loop; other site 639283002580 H-loop/switch region; other site 639283002581 TOBE domain; Region: TOBE_2; pfam08402 639283002582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283002583 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 639283002584 NAD(P) binding site [chemical binding]; other site 639283002585 active site 639283002586 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 639283002587 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 639283002588 N- and C-terminal domain interface [polypeptide binding]; other site 639283002589 active site 639283002590 MgATP binding site [chemical binding]; other site 639283002591 catalytic site [active] 639283002592 metal binding site [ion binding]; metal-binding site 639283002593 carbohydrate binding site [chemical binding]; other site 639283002594 putative homodimer interface [polypeptide binding]; other site 639283002595 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 639283002596 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 639283002597 putative substrate binding site [chemical binding]; other site 639283002598 putative ATP binding site [chemical binding]; other site 639283002599 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 639283002600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283002601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283002602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 639283002603 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283002604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002605 conserved gate region; other site 639283002606 dimer interface [polypeptide binding]; other site 639283002607 putative PBP binding loops; other site 639283002608 ABC-ATPase subunit interface; other site 639283002609 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283002610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002611 dimer interface [polypeptide binding]; other site 639283002612 conserved gate region; other site 639283002613 putative PBP binding loops; other site 639283002614 ABC-ATPase subunit interface; other site 639283002615 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 639283002616 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 639283002617 Walker A/P-loop; other site 639283002618 ATP binding site [chemical binding]; other site 639283002619 Q-loop/lid; other site 639283002620 ABC transporter signature motif; other site 639283002621 Walker B; other site 639283002622 D-loop; other site 639283002623 H-loop/switch region; other site 639283002624 TOBE domain; Region: TOBE_2; pfam08402 639283002625 TOBE domain; Region: TOBE_2; pfam08402 639283002626 short chain dehydrogenase; Provisional; Region: PRK07060 639283002627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283002628 NAD(P) binding site [chemical binding]; other site 639283002629 active site 639283002630 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 639283002631 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 639283002632 inhibitor binding site; inhibition site 639283002633 catalytic Zn binding site [ion binding]; other site 639283002634 structural Zn binding site [ion binding]; other site 639283002635 NADP binding site [chemical binding]; other site 639283002636 tetramer interface [polypeptide binding]; other site 639283002637 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 639283002638 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 639283002639 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283002640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002641 dimer interface [polypeptide binding]; other site 639283002642 conserved gate region; other site 639283002643 putative PBP binding loops; other site 639283002644 ABC-ATPase subunit interface; other site 639283002645 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283002646 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283002647 Walker A/P-loop; other site 639283002648 ATP binding site [chemical binding]; other site 639283002649 Q-loop/lid; other site 639283002650 ABC transporter signature motif; other site 639283002651 Walker B; other site 639283002652 D-loop; other site 639283002653 H-loop/switch region; other site 639283002654 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 639283002655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283002656 substrate binding pocket [chemical binding]; other site 639283002657 membrane-bound complex binding site; other site 639283002658 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 639283002659 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 639283002660 active site 639283002661 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283002662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002663 dimer interface [polypeptide binding]; other site 639283002664 conserved gate region; other site 639283002665 putative PBP binding loops; other site 639283002666 ABC-ATPase subunit interface; other site 639283002667 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283002668 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283002669 Walker A/P-loop; other site 639283002670 ATP binding site [chemical binding]; other site 639283002671 Q-loop/lid; other site 639283002672 ABC transporter signature motif; other site 639283002673 Walker B; other site 639283002674 D-loop; other site 639283002675 H-loop/switch region; other site 639283002676 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 639283002677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283002678 membrane-bound complex binding site; other site 639283002679 hinge residues; other site 639283002680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 639283002681 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 639283002682 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 639283002683 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 639283002684 active site 639283002685 dimer interface [polypeptide binding]; other site 639283002686 non-prolyl cis peptide bond; other site 639283002687 insertion regions; other site 639283002688 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283002689 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283002690 Walker A/P-loop; other site 639283002691 ATP binding site [chemical binding]; other site 639283002692 Q-loop/lid; other site 639283002693 ABC transporter signature motif; other site 639283002694 Walker B; other site 639283002695 D-loop; other site 639283002696 H-loop/switch region; other site 639283002697 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283002698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002699 dimer interface [polypeptide binding]; other site 639283002700 conserved gate region; other site 639283002701 putative PBP binding loops; other site 639283002702 ABC-ATPase subunit interface; other site 639283002703 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 639283002704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283002705 substrate binding pocket [chemical binding]; other site 639283002706 membrane-bound complex binding site; other site 639283002707 hinge residues; other site 639283002708 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 639283002709 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 639283002710 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283002711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002712 dimer interface [polypeptide binding]; other site 639283002713 conserved gate region; other site 639283002714 ABC-ATPase subunit interface; other site 639283002715 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 639283002716 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283002717 Walker A/P-loop; other site 639283002718 ATP binding site [chemical binding]; other site 639283002719 Q-loop/lid; other site 639283002720 ABC transporter signature motif; other site 639283002721 Walker B; other site 639283002722 D-loop; other site 639283002723 H-loop/switch region; other site 639283002724 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 639283002725 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283002726 substrate binding pocket [chemical binding]; other site 639283002727 membrane-bound complex binding site; other site 639283002728 hinge residues; other site 639283002729 Predicted transcriptional regulator [Transcription]; Region: COG1959 639283002730 Transcriptional regulator; Region: Rrf2; pfam02082 639283002731 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283002732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002733 dimer interface [polypeptide binding]; other site 639283002734 ABC-ATPase subunit interface; other site 639283002735 putative PBP binding loops; other site 639283002736 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283002737 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283002738 Walker A/P-loop; other site 639283002739 ATP binding site [chemical binding]; other site 639283002740 Q-loop/lid; other site 639283002741 ABC transporter signature motif; other site 639283002742 Walker B; other site 639283002743 D-loop; other site 639283002744 H-loop/switch region; other site 639283002745 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 639283002746 NMT1-like family; Region: NMT1_2; pfam13379 639283002747 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 639283002748 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 639283002749 active site 639283002750 dimer interface [polypeptide binding]; other site 639283002751 non-prolyl cis peptide bond; other site 639283002752 insertion regions; other site 639283002753 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 639283002754 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 639283002755 active site 639283002756 DNA binding site [nucleotide binding] 639283002757 Int/Topo IB signature motif; other site 639283002758 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 639283002759 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 639283002760 FMN binding site [chemical binding]; other site 639283002761 active site 639283002762 catalytic residues [active] 639283002763 substrate binding site [chemical binding]; other site 639283002764 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 639283002765 Predicted aspartyl protease [General function prediction only]; Region: COG3577 639283002766 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 639283002767 catalytic motif [active] 639283002768 Catalytic residue [active] 639283002769 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 639283002770 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 639283002771 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 639283002772 FMN binding site [chemical binding]; other site 639283002773 dimer interface [polypeptide binding]; other site 639283002774 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 639283002775 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 639283002776 putative dimer interface [polypeptide binding]; other site 639283002777 active site pocket [active] 639283002778 putative cataytic base [active] 639283002779 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 639283002780 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 639283002781 Catalytic site; other site 639283002782 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 639283002783 putative uracil binding site [chemical binding]; other site 639283002784 putative active site [active] 639283002785 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002787 dimer interface [polypeptide binding]; other site 639283002788 conserved gate region; other site 639283002789 putative PBP binding loops; other site 639283002790 ABC-ATPase subunit interface; other site 639283002791 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283002792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283002793 dimer interface [polypeptide binding]; other site 639283002794 conserved gate region; other site 639283002795 putative PBP binding loops; other site 639283002796 ABC-ATPase subunit interface; other site 639283002797 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 639283002798 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283002799 substrate binding pocket [chemical binding]; other site 639283002800 membrane-bound complex binding site; other site 639283002801 hinge residues; other site 639283002802 Domain of unknown function DUF59; Region: DUF59; pfam01883 639283002803 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 639283002804 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 639283002805 Walker A motif; other site 639283002806 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 639283002807 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 639283002808 tetramer interface [polypeptide binding]; other site 639283002809 active site 639283002810 Mg2+/Mn2+ binding site [ion binding]; other site 639283002811 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 639283002812 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 639283002813 oligomeric interface; other site 639283002814 putative active site [active] 639283002815 homodimer interface [polypeptide binding]; other site 639283002816 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 639283002817 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 639283002818 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 639283002819 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 639283002820 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 639283002821 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 639283002822 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 639283002823 EamA-like transporter family; Region: EamA; pfam00892 639283002824 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 639283002825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283002826 putative substrate translocation pore; other site 639283002827 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 639283002828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283002829 FeS/SAM binding site; other site 639283002830 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 639283002831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 639283002832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283002833 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283002834 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 639283002835 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; Region: PGM_PMM_I; pfam02878 639283002836 phosphoglycolate phosphatase; Provisional; Region: PRK13222 639283002837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283002838 motif II; other site 639283002839 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 639283002840 tetramer (dimer of dimers) interface [polypeptide binding]; other site 639283002841 active site 639283002842 dimer interface [polypeptide binding]; other site 639283002843 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 639283002844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 639283002845 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283002846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283002847 glutathione reductase; Validated; Region: PRK06116 639283002848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283002849 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 639283002850 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 639283002851 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 639283002852 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 639283002853 putative NAD(P) binding site [chemical binding]; other site 639283002854 dimer interface [polypeptide binding]; other site 639283002855 Predicted transcriptional regulators [Transcription]; Region: COG1733 639283002856 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 639283002857 Rhamnan synthesis protein F; Region: RgpF; pfam05045 639283002858 NAD synthetase; Provisional; Region: PRK13981 639283002859 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 639283002860 multimer interface [polypeptide binding]; other site 639283002861 active site 639283002862 catalytic triad [active] 639283002863 protein interface 1 [polypeptide binding]; other site 639283002864 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 639283002865 homodimer interface [polypeptide binding]; other site 639283002866 NAD binding pocket [chemical binding]; other site 639283002867 ATP binding pocket [chemical binding]; other site 639283002868 Mg binding site [ion binding]; other site 639283002869 active-site loop [active] 639283002870 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 639283002871 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 639283002872 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 639283002873 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 639283002874 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 639283002875 active site 639283002876 HIGH motif; other site 639283002877 nucleotide binding site [chemical binding]; other site 639283002878 active site 639283002879 KMSKS motif; other site 639283002880 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 639283002881 CreA protein; Region: CreA; pfam05981 639283002882 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 639283002883 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 639283002884 active site 639283002885 HIGH motif; other site 639283002886 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 639283002887 KMSKS motif; other site 639283002888 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 639283002889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 639283002890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283002891 Coenzyme A binding pocket [chemical binding]; other site 639283002892 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 639283002893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283002894 putative DNA binding site [nucleotide binding]; other site 639283002895 putative Zn2+ binding site [ion binding]; other site 639283002896 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 639283002897 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 639283002898 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 639283002899 Walker A/P-loop; other site 639283002900 ATP binding site [chemical binding]; other site 639283002901 Q-loop/lid; other site 639283002902 ABC transporter signature motif; other site 639283002903 Walker B; other site 639283002904 D-loop; other site 639283002905 H-loop/switch region; other site 639283002906 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 639283002907 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 639283002908 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 639283002909 Protease inhibitor Inh; Region: Inh; pfam02974 639283002910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283002911 NAD(P) binding site [chemical binding]; other site 639283002912 active site 639283002913 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 639283002914 Chromate transporter; Region: Chromate_transp; pfam02417 639283002915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283002916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283002917 dimerization interface [polypeptide binding]; other site 639283002918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 639283002919 active site residue [active] 639283002920 aminotransferase; Validated; Region: PRK07046 639283002921 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 639283002922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283002923 catalytic residue [active] 639283002924 putative aminotransferase; Validated; Region: PRK07480 639283002925 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 639283002926 inhibitor-cofactor binding pocket; inhibition site 639283002927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283002928 catalytic residue [active] 639283002929 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 639283002930 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 639283002931 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 639283002932 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283002933 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 639283002934 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 639283002935 putative acyl-acceptor binding pocket; other site 639283002936 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 639283002937 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 639283002938 NAD(P) binding site [chemical binding]; other site 639283002939 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 639283002940 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 639283002941 dimer interface [polypeptide binding]; other site 639283002942 active site 639283002943 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 639283002944 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 639283002945 active site 639283002946 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 639283002947 active site 2 [active] 639283002948 active site 1 [active] 639283002949 acyl carrier protein; Provisional; Region: PRK06508 639283002950 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 639283002951 MG2 domain; Region: A2M_N; pfam01835 639283002952 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 639283002953 surface patch; other site 639283002954 thioester region; other site 639283002955 specificity defining residues; other site 639283002956 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 639283002957 Transglycosylase; Region: Transgly; pfam00912 639283002958 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 639283002959 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 639283002960 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 639283002961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 639283002962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283002963 dimer interface [polypeptide binding]; other site 639283002964 phosphorylation site [posttranslational modification] 639283002965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283002966 Mg2+ binding site [ion binding]; other site 639283002967 G-X-G motif; other site 639283002968 Predicted membrane protein [Function unknown]; Region: COG3174 639283002969 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 639283002970 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 639283002971 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 639283002972 catalytic residues [active] 639283002973 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 639283002974 DNA-binding interface [nucleotide binding]; DNA binding site 639283002975 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 639283002976 exopolyphosphatase; Region: exo_poly_only; TIGR03706 639283002977 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 639283002978 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 639283002979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283002980 S-adenosylmethionine binding site [chemical binding]; other site 639283002981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283002982 putative transporter; Provisional; Region: PRK10504 639283002983 putative substrate translocation pore; other site 639283002984 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 639283002985 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 639283002986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 639283002987 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 639283002988 active site 639283002989 MAPEG family; Region: MAPEG; cl09190 639283002990 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 639283002991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283002992 S-adenosylmethionine binding site [chemical binding]; other site 639283002993 GMP synthase; Reviewed; Region: guaA; PRK00074 639283002994 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 639283002995 AMP/PPi binding site [chemical binding]; other site 639283002996 candidate oxyanion hole; other site 639283002997 catalytic triad [active] 639283002998 potential glutamine specificity residues [chemical binding]; other site 639283002999 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 639283003000 ATP Binding subdomain [chemical binding]; other site 639283003001 Ligand Binding sites [chemical binding]; other site 639283003002 Dimerization subdomain; other site 639283003003 Response regulator receiver domain; Region: Response_reg; pfam00072 639283003004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283003005 active site 639283003006 phosphorylation site [posttranslational modification] 639283003007 intermolecular recognition site; other site 639283003008 dimerization interface [polypeptide binding]; other site 639283003009 PAS fold; Region: PAS_4; pfam08448 639283003010 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283003011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283003012 metal binding site [ion binding]; metal-binding site 639283003013 active site 639283003014 I-site; other site 639283003015 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283003016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283003017 dimer interface [polypeptide binding]; other site 639283003018 phosphorylation site [posttranslational modification] 639283003019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283003020 ATP binding site [chemical binding]; other site 639283003021 Mg2+ binding site [ion binding]; other site 639283003022 G-X-G motif; other site 639283003023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283003024 Response regulator receiver domain; Region: Response_reg; pfam00072 639283003025 active site 639283003026 phosphorylation site [posttranslational modification] 639283003027 intermolecular recognition site; other site 639283003028 dimerization interface [polypeptide binding]; other site 639283003029 Hpt domain; Region: Hpt; pfam01627 639283003030 enoyl-CoA hydratase; Validated; Region: PRK08788 639283003031 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 639283003032 substrate binding site [chemical binding]; other site 639283003033 oxyanion hole (OAH) forming residues; other site 639283003034 trimer interface [polypeptide binding]; other site 639283003035 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 639283003036 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 639283003037 DsrE/DsrF-like family; Region: DrsE; cl00672 639283003038 Cytochrome c; Region: Cytochrom_C; pfam00034 639283003039 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 639283003040 Moco binding site; other site 639283003041 metal coordination site [ion binding]; other site 639283003042 dimerization interface [polypeptide binding]; other site 639283003043 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 639283003044 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 639283003045 active site 639283003046 metal binding site [ion binding]; metal-binding site 639283003047 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 639283003048 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 639283003049 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 639283003050 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 639283003051 Cytochrome c [Energy production and conversion]; Region: COG3258 639283003052 Cytochrome c; Region: Cytochrom_C; pfam00034 639283003053 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 639283003054 catalytic residues [active] 639283003055 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 639283003056 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 639283003057 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 639283003058 Predicted transporter component [General function prediction only]; Region: COG2391 639283003059 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283003060 dimerization interface [polypeptide binding]; other site 639283003061 putative DNA binding site [nucleotide binding]; other site 639283003062 putative Zn2+ binding site [ion binding]; other site 639283003063 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 639283003064 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 639283003065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283003066 dimerization interface [polypeptide binding]; other site 639283003067 putative DNA binding site [nucleotide binding]; other site 639283003068 putative Zn2+ binding site [ion binding]; other site 639283003069 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 639283003070 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 639283003071 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 639283003072 Putative phosphatase (DUF442); Region: DUF442; cl17385 639283003073 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 639283003074 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 639283003075 SnoaL-like domain; Region: SnoaL_2; pfam12680 639283003076 Domain of unknown function (DUF305); Region: DUF305; cl17794 639283003077 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 639283003078 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283003079 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283003080 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 639283003081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283003082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 639283003083 DNA binding residues [nucleotide binding] 639283003084 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 639283003085 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 639283003086 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 639283003087 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 639283003088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283003089 DNA-binding site [nucleotide binding]; DNA binding site 639283003090 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 639283003091 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 639283003092 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283003093 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283003094 active site 639283003095 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 639283003096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283003097 substrate binding pocket [chemical binding]; other site 639283003098 membrane-bound complex binding site; other site 639283003099 hinge residues; other site 639283003100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283003101 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 639283003102 Walker A/P-loop; other site 639283003103 ATP binding site [chemical binding]; other site 639283003104 Q-loop/lid; other site 639283003105 ABC transporter signature motif; other site 639283003106 Walker B; other site 639283003107 D-loop; other site 639283003108 H-loop/switch region; other site 639283003109 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 639283003110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283003111 dimer interface [polypeptide binding]; other site 639283003112 conserved gate region; other site 639283003113 ABC-ATPase subunit interface; other site 639283003114 Methyltransferase domain; Region: Methyltransf_31; pfam13847 639283003115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283003116 S-adenosylmethionine binding site [chemical binding]; other site 639283003117 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 639283003118 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 639283003119 Walker A/P-loop; other site 639283003120 ATP binding site [chemical binding]; other site 639283003121 Q-loop/lid; other site 639283003122 ABC transporter signature motif; other site 639283003123 Walker B; other site 639283003124 D-loop; other site 639283003125 H-loop/switch region; other site 639283003126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 639283003127 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 639283003128 HSP70 interaction site [polypeptide binding]; other site 639283003129 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 639283003130 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 639283003131 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 639283003132 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 639283003133 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 639283003134 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 639283003135 Cytochrome c; Region: Cytochrom_C; pfam00034 639283003136 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 639283003137 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 639283003138 D-pathway; other site 639283003139 Putative ubiquinol binding site [chemical binding]; other site 639283003140 Low-spin heme (heme b) binding site [chemical binding]; other site 639283003141 Putative water exit pathway; other site 639283003142 Binuclear center (heme o3/CuB) [ion binding]; other site 639283003143 K-pathway; other site 639283003144 Putative proton exit pathway; other site 639283003145 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 639283003146 Subunit I/III interface [polypeptide binding]; other site 639283003147 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 639283003148 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 639283003149 Cytochrome c; Region: Cytochrom_C; cl11414 639283003150 Cytochrome c; Region: Cytochrom_C; cl11414 639283003151 aconitate hydratase; Provisional; Region: acnA; PRK12881 639283003152 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 639283003153 substrate binding site [chemical binding]; other site 639283003154 ligand binding site [chemical binding]; other site 639283003155 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 639283003156 substrate binding site [chemical binding]; other site 639283003157 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283003158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283003159 DNA-binding site [nucleotide binding]; DNA binding site 639283003160 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283003161 FCD domain; Region: FCD; pfam07729 639283003162 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 639283003163 tartrate dehydrogenase; Region: TTC; TIGR02089 639283003164 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 639283003165 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283003166 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 639283003167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283003168 dimer interface [polypeptide binding]; other site 639283003169 conserved gate region; other site 639283003170 putative PBP binding loops; other site 639283003171 ABC-ATPase subunit interface; other site 639283003172 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283003173 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 639283003174 Walker A/P-loop; other site 639283003175 ATP binding site [chemical binding]; other site 639283003176 Q-loop/lid; other site 639283003177 ABC transporter signature motif; other site 639283003178 Walker B; other site 639283003179 D-loop; other site 639283003180 H-loop/switch region; other site 639283003181 TOBE domain; Region: TOBE_2; pfam08402 639283003182 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 639283003183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283003184 S-adenosylmethionine binding site [chemical binding]; other site 639283003185 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 639283003186 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 639283003187 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 639283003188 putative hydrophobic ligand binding site [chemical binding]; other site 639283003189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283003190 dimerization interface [polypeptide binding]; other site 639283003191 putative DNA binding site [nucleotide binding]; other site 639283003192 putative Zn2+ binding site [ion binding]; other site 639283003193 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 639283003194 active site clefts [active] 639283003195 zinc binding site [ion binding]; other site 639283003196 dimer interface [polypeptide binding]; other site 639283003197 Cytochrome c2 [Energy production and conversion]; Region: COG3474 639283003198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 639283003199 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 639283003200 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 639283003201 Trp docking motif [polypeptide binding]; other site 639283003202 dimer interface [polypeptide binding]; other site 639283003203 active site 639283003204 small subunit binding site [polypeptide binding]; other site 639283003205 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 639283003206 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 639283003207 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283003208 substrate binding pocket [chemical binding]; other site 639283003209 membrane-bound complex binding site; other site 639283003210 hinge residues; other site 639283003211 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 639283003212 active site residue [active] 639283003213 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 639283003214 ABC-2 type transporter; Region: ABC2_membrane; cl17235 639283003215 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 639283003216 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 639283003217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283003218 Walker A/P-loop; other site 639283003219 ATP binding site [chemical binding]; other site 639283003220 Q-loop/lid; other site 639283003221 ABC transporter signature motif; other site 639283003222 Walker B; other site 639283003223 D-loop; other site 639283003224 H-loop/switch region; other site 639283003225 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 639283003226 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 639283003227 structural tetrad; other site 639283003228 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283003229 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 639283003230 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283003231 ligand binding site [chemical binding]; other site 639283003232 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 639283003233 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 639283003234 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283003235 substrate binding pocket [chemical binding]; other site 639283003236 membrane-bound complex binding site; other site 639283003237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283003238 putative PBP binding loops; other site 639283003239 dimer interface [polypeptide binding]; other site 639283003240 ABC-ATPase subunit interface; other site 639283003241 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283003242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283003243 Walker A/P-loop; other site 639283003244 ATP binding site [chemical binding]; other site 639283003245 Q-loop/lid; other site 639283003246 ABC transporter signature motif; other site 639283003247 Walker B; other site 639283003248 D-loop; other site 639283003249 H-loop/switch region; other site 639283003250 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 639283003251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 639283003252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283003253 dimer interface [polypeptide binding]; other site 639283003254 phosphorylation site [posttranslational modification] 639283003255 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 639283003256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283003257 ATP binding site [chemical binding]; other site 639283003258 Mg2+ binding site [ion binding]; other site 639283003259 G-X-G motif; other site 639283003260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283003261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283003262 active site 639283003263 phosphorylation site [posttranslational modification] 639283003264 intermolecular recognition site; other site 639283003265 dimerization interface [polypeptide binding]; other site 639283003266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283003267 DNA binding site [nucleotide binding] 639283003268 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 639283003269 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 639283003270 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 639283003271 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 639283003272 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 639283003273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283003274 FeS/SAM binding site; other site 639283003275 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 639283003276 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 639283003277 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 639283003278 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 639283003279 ArsC family; Region: ArsC; pfam03960 639283003280 putative catalytic residues [active] 639283003281 Uncharacterized conserved protein [Function unknown]; Region: COG1359 639283003282 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 639283003283 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 639283003284 G1 box; other site 639283003285 putative GEF interaction site [polypeptide binding]; other site 639283003286 GTP/Mg2+ binding site [chemical binding]; other site 639283003287 Switch I region; other site 639283003288 G2 box; other site 639283003289 G3 box; other site 639283003290 Switch II region; other site 639283003291 G4 box; other site 639283003292 G5 box; other site 639283003293 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 639283003294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283003295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283003296 metal binding site [ion binding]; metal-binding site 639283003297 active site 639283003298 I-site; other site 639283003299 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283003300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283003301 NnrU protein; Region: NnrU; pfam07298 639283003302 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 639283003303 oligomerization interface [polypeptide binding]; other site 639283003304 active site 639283003305 metal binding site [ion binding]; metal-binding site 639283003306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 639283003307 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 639283003308 GTP-binding protein Der; Reviewed; Region: PRK00093 639283003309 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 639283003310 G1 box; other site 639283003311 GTP/Mg2+ binding site [chemical binding]; other site 639283003312 Switch I region; other site 639283003313 G2 box; other site 639283003314 Switch II region; other site 639283003315 G3 box; other site 639283003316 G4 box; other site 639283003317 G5 box; other site 639283003318 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 639283003319 G1 box; other site 639283003320 GTP/Mg2+ binding site [chemical binding]; other site 639283003321 Switch I region; other site 639283003322 G2 box; other site 639283003323 G3 box; other site 639283003324 Switch II region; other site 639283003325 G4 box; other site 639283003326 G5 box; other site 639283003327 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 639283003328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283003329 NAD(P) binding site [chemical binding]; other site 639283003330 active site 639283003331 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 639283003332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283003333 amidophosphoribosyltransferase; Provisional; Region: PRK09123 639283003334 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 639283003335 active site 639283003336 tetramer interface [polypeptide binding]; other site 639283003337 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283003338 active site 639283003339 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 639283003340 Colicin V production protein; Region: Colicin_V; pfam02674 639283003341 DNA repair protein RadA; Provisional; Region: PRK11823 639283003342 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 639283003343 Walker A motif; other site 639283003344 ATP binding site [chemical binding]; other site 639283003345 Walker B motif; other site 639283003346 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 639283003347 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 639283003348 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 639283003349 active site 639283003350 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 639283003351 dimer interface [polypeptide binding]; other site 639283003352 substrate binding site [chemical binding]; other site 639283003353 catalytic residues [active] 639283003354 replicative DNA helicase; Provisional; Region: PRK09165 639283003355 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 639283003356 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 639283003357 Walker A motif; other site 639283003358 ATP binding site [chemical binding]; other site 639283003359 Walker B motif; other site 639283003360 DNA binding loops [nucleotide binding] 639283003361 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 639283003362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283003363 S-adenosylmethionine binding site [chemical binding]; other site 639283003364 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 639283003365 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 639283003366 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 639283003367 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 639283003368 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 639283003369 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 639283003370 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 639283003371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283003372 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 639283003373 NAD(P) binding site [chemical binding]; other site 639283003374 active site 639283003375 acyl carrier protein; Provisional; Region: acpP; PRK00982 639283003376 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 639283003377 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 639283003378 dimer interface [polypeptide binding]; other site 639283003379 active site 639283003380 YceG-like family; Region: YceG; pfam02618 639283003381 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 639283003382 dimerization interface [polypeptide binding]; other site 639283003383 hypothetical protein; Provisional; Region: PRK11820 639283003384 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 639283003385 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 639283003386 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 639283003387 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 639283003388 catalytic site [active] 639283003389 G-X2-G-X-G-K; other site 639283003390 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 639283003391 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 639283003392 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 639283003393 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 639283003394 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 639283003395 SurA N-terminal domain; Region: SurA_N; pfam09312 639283003396 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 639283003397 OstA-like protein; Region: OstA; cl00844 639283003398 Organic solvent tolerance protein; Region: OstA_C; pfam04453 639283003399 Predicted permeases [General function prediction only]; Region: COG0795 639283003400 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 639283003401 Predicted permeases [General function prediction only]; Region: COG0795 639283003402 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 639283003403 multifunctional aminopeptidase A; Provisional; Region: PRK00913 639283003404 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 639283003405 interface (dimer of trimers) [polypeptide binding]; other site 639283003406 Substrate-binding/catalytic site; other site 639283003407 Zn-binding sites [ion binding]; other site 639283003408 DNA polymerase III subunit chi; Validated; Region: PRK05728 639283003409 Porin subfamily; Region: Porin_2; pfam02530 639283003410 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 639283003411 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 639283003412 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 639283003413 ABC transporter; Region: ABC_tran_2; pfam12848 639283003414 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 639283003415 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 639283003416 DinB family; Region: DinB; cl17821 639283003417 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 639283003418 amphipathic channel; other site 639283003419 Asn-Pro-Ala signature motifs; other site 639283003420 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 639283003421 active site 639283003422 multimer interface [polypeptide binding]; other site 639283003423 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 639283003424 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 639283003425 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 639283003426 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 639283003427 putative [4Fe-4S] binding site [ion binding]; other site 639283003428 putative molybdopterin cofactor binding site [chemical binding]; other site 639283003429 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 639283003430 putative molybdopterin cofactor binding site; other site 639283003431 Putative cyclase; Region: Cyclase; pfam04199 639283003432 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 639283003433 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 639283003434 active site 639283003435 substrate binding site [chemical binding]; other site 639283003436 cosubstrate binding site; other site 639283003437 catalytic site [active] 639283003438 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 639283003439 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 639283003440 dimerization interface [polypeptide binding]; other site 639283003441 putative ATP binding site [chemical binding]; other site 639283003442 Benzoate membrane transport protein; Region: BenE; pfam03594 639283003443 benzoate transporter; Region: benE; TIGR00843 639283003444 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 639283003445 Domain of unknown function DUF20; Region: UPF0118; pfam01594 639283003446 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 639283003447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 639283003448 polyphosphate kinase; Provisional; Region: PRK05443 639283003449 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 639283003450 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 639283003451 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 639283003452 putative domain interface [polypeptide binding]; other site 639283003453 putative active site [active] 639283003454 catalytic site [active] 639283003455 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 639283003456 putative active site [active] 639283003457 putative domain interface [polypeptide binding]; other site 639283003458 catalytic site [active] 639283003459 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 639283003460 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 639283003461 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 639283003462 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 639283003463 catalytic site [active] 639283003464 putative active site [active] 639283003465 putative substrate binding site [chemical binding]; other site 639283003466 HRDC domain; Region: HRDC; pfam00570 639283003467 Protein of unknown function (DUF992); Region: DUF992; pfam06186 639283003468 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 639283003469 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 639283003470 dimer interface [polypeptide binding]; other site 639283003471 anticodon binding site; other site 639283003472 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 639283003473 homodimer interface [polypeptide binding]; other site 639283003474 motif 1; other site 639283003475 active site 639283003476 motif 2; other site 639283003477 GAD domain; Region: GAD; pfam02938 639283003478 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 639283003479 active site 639283003480 motif 3; other site 639283003481 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 639283003482 Malic enzyme, N-terminal domain; Region: malic; pfam00390 639283003483 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 639283003484 putative NAD(P) binding site [chemical binding]; other site 639283003485 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 639283003486 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 639283003487 DNA-binding site [nucleotide binding]; DNA binding site 639283003488 RNA-binding motif; other site 639283003489 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 639283003490 DNA-binding site [nucleotide binding]; DNA binding site 639283003491 RNA-binding motif; other site 639283003492 Uncharacterized conserved protein [Function unknown]; Region: COG3791 639283003493 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 639283003494 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 639283003495 putative DNA binding site [nucleotide binding]; other site 639283003496 putative Zn2+ binding site [ion binding]; other site 639283003497 AsnC family; Region: AsnC_trans_reg; pfam01037 639283003498 Arginase family; Region: Arginase; cd09989 639283003499 active site 639283003500 Mn binding site [ion binding]; other site 639283003501 oligomer interface [polypeptide binding]; other site 639283003502 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 639283003503 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 639283003504 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 639283003505 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 639283003506 putative trimer interface [polypeptide binding]; other site 639283003507 putative CoA binding site [chemical binding]; other site 639283003508 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 639283003509 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283003510 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283003511 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 639283003512 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283003513 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 639283003514 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 639283003515 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 639283003516 inhibitor-cofactor binding pocket; inhibition site 639283003517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283003518 catalytic residue [active] 639283003519 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 639283003520 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 639283003521 NnrS protein; Region: NnrS; pfam05940 639283003522 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 639283003523 pseudoazurin; Region: pseudoazurin; TIGR02375 639283003524 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 639283003525 Uncharacterized conserved protein [Function unknown]; Region: COG1262 639283003526 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 639283003527 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 639283003528 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 639283003529 Multicopper oxidase; Region: Cu-oxidase; pfam00394 639283003530 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 639283003531 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 639283003532 ligand binding site [chemical binding]; other site 639283003533 flexible hinge region; other site 639283003534 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 639283003535 non-specific DNA interactions [nucleotide binding]; other site 639283003536 DNA binding site [nucleotide binding] 639283003537 sequence specific DNA binding site [nucleotide binding]; other site 639283003538 putative cAMP binding site [chemical binding]; other site 639283003539 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 639283003540 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 639283003541 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 639283003542 HemN C-terminal domain; Region: HemN_C; pfam06969 639283003543 NnrS protein; Region: NnrS; pfam05940 639283003544 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 639283003545 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 639283003546 metal ion-dependent adhesion site (MIDAS); other site 639283003547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283003548 MoxR-like ATPases [General function prediction only]; Region: COG0714 639283003549 Walker A motif; other site 639283003550 ATP binding site [chemical binding]; other site 639283003551 Walker B motif; other site 639283003552 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 639283003553 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 639283003554 Low-spin heme binding site [chemical binding]; other site 639283003555 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 639283003556 D-pathway; other site 639283003557 K-pathway; other site 639283003558 Binuclear center (active site) [active] 639283003559 Putative proton exit pathway; other site 639283003560 Cytochrome c; Region: Cytochrom_C; pfam00034 639283003561 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 639283003562 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 639283003563 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 639283003564 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 639283003565 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 639283003566 [4Fe-4S] binding site [ion binding]; other site 639283003567 molybdopterin cofactor binding site; other site 639283003568 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 639283003569 molybdopterin cofactor binding site; other site 639283003570 NapD protein; Region: NapD; pfam03927 639283003571 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 639283003572 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 639283003573 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 639283003574 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 639283003575 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 639283003576 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 639283003577 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 639283003578 FAD binding pocket [chemical binding]; other site 639283003579 FAD binding motif [chemical binding]; other site 639283003580 phosphate binding motif [ion binding]; other site 639283003581 beta-alpha-beta structure motif; other site 639283003582 NAD binding pocket [chemical binding]; other site 639283003583 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 639283003584 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 639283003585 ApbE family; Region: ApbE; pfam02424 639283003586 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 639283003587 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 639283003588 FAD binding pocket [chemical binding]; other site 639283003589 FAD binding motif [chemical binding]; other site 639283003590 catalytic residues [active] 639283003591 NAD binding pocket [chemical binding]; other site 639283003592 phosphate binding motif [ion binding]; other site 639283003593 beta-alpha-beta structure motif; other site 639283003594 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 639283003595 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 639283003596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283003597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283003598 active site 639283003599 phosphorylation site [posttranslational modification] 639283003600 intermolecular recognition site; other site 639283003601 dimerization interface [polypeptide binding]; other site 639283003602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283003603 DNA binding site [nucleotide binding] 639283003604 sensor protein QseC; Provisional; Region: PRK10337 639283003605 HAMP domain; Region: HAMP; pfam00672 639283003606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283003607 dimer interface [polypeptide binding]; other site 639283003608 phosphorylation site [posttranslational modification] 639283003609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283003610 ATP binding site [chemical binding]; other site 639283003611 Mg2+ binding site [ion binding]; other site 639283003612 G-X-G motif; other site 639283003613 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 639283003614 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 639283003615 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 639283003616 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283003617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283003618 active site 639283003619 phosphorylation site [posttranslational modification] 639283003620 intermolecular recognition site; other site 639283003621 dimerization interface [polypeptide binding]; other site 639283003622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283003623 DNA binding site [nucleotide binding] 639283003624 Response regulator receiver domain; Region: Response_reg; pfam00072 639283003625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283003626 active site 639283003627 phosphorylation site [posttranslational modification] 639283003628 intermolecular recognition site; other site 639283003629 dimerization interface [polypeptide binding]; other site 639283003630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283003631 ATP binding site [chemical binding]; other site 639283003632 G-X-G motif; other site 639283003633 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 639283003634 Na binding site [ion binding]; other site 639283003635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283003636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283003637 dimer interface [polypeptide binding]; other site 639283003638 phosphorylation site [posttranslational modification] 639283003639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283003640 ATP binding site [chemical binding]; other site 639283003641 G-X-G motif; other site 639283003642 Transcriptional regulator; Region: Rrf2; cl17282 639283003643 Rrf2 family protein; Region: rrf2_super; TIGR00738 639283003644 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 639283003645 heme-binding site [chemical binding]; other site 639283003646 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 639283003647 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 639283003648 heme-binding site [chemical binding]; other site 639283003649 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 639283003650 FAD binding pocket [chemical binding]; other site 639283003651 FAD binding motif [chemical binding]; other site 639283003652 phosphate binding motif [ion binding]; other site 639283003653 beta-alpha-beta structure motif; other site 639283003654 NAD binding pocket [chemical binding]; other site 639283003655 Heme binding pocket [chemical binding]; other site 639283003656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283003657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283003658 metal binding site [ion binding]; metal-binding site 639283003659 active site 639283003660 I-site; other site 639283003661 HAMP domain; Region: HAMP; pfam00672 639283003662 dimerization interface [polypeptide binding]; other site 639283003663 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283003664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283003665 metal binding site [ion binding]; metal-binding site 639283003666 active site 639283003667 I-site; other site 639283003668 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283003669 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 639283003670 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 639283003671 Beta-Casp domain; Region: Beta-Casp; smart01027 639283003672 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 639283003673 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 639283003674 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283003675 active site 639283003676 thymidine phosphorylase; Provisional; Region: PRK04350 639283003677 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 639283003678 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 639283003679 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283003680 active site 639283003681 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 639283003682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 639283003683 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 639283003684 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 639283003685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283003686 active site 639283003687 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 639283003688 Ligand Binding Site [chemical binding]; other site 639283003689 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 639283003690 FOG: CBS domain [General function prediction only]; Region: COG0517 639283003691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 639283003692 BON domain; Region: BON; pfam04972 639283003693 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 639283003694 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 639283003695 putative dimer interface [polypeptide binding]; other site 639283003696 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283003697 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283003698 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283003699 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 639283003700 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 639283003701 FtsX-like permease family; Region: FtsX; pfam02687 639283003702 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 639283003703 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 639283003704 Walker A/P-loop; other site 639283003705 ATP binding site [chemical binding]; other site 639283003706 Q-loop/lid; other site 639283003707 ABC transporter signature motif; other site 639283003708 Walker B; other site 639283003709 D-loop; other site 639283003710 H-loop/switch region; other site 639283003711 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 639283003712 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 639283003713 Sulfate transporter family; Region: Sulfate_transp; pfam00916 639283003714 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 639283003715 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 639283003716 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 639283003717 conserved cys residue [active] 639283003718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283003719 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 639283003720 TIGR03032 family protein; Region: TIGR03032 639283003721 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 639283003722 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 639283003723 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 639283003724 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 639283003725 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 639283003726 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 639283003727 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 639283003728 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 639283003729 Major royal jelly protein; Region: MRJP; pfam03022 639283003730 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 639283003731 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 639283003732 putative NAD(P) binding site [chemical binding]; other site 639283003733 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283003734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283003735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283003736 dimerization interface [polypeptide binding]; other site 639283003737 Domain of unknown function (DUF336); Region: DUF336; cl01249 639283003738 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 639283003739 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 639283003740 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 639283003741 putative NAD(P) binding site [chemical binding]; other site 639283003742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283003743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283003744 LysR substrate binding domain; Region: LysR_substrate; pfam03466 639283003745 dimerization interface [polypeptide binding]; other site 639283003746 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 639283003747 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 639283003748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283003749 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283003750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283003751 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 639283003752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283003753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283003754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283003755 dimerization interface [polypeptide binding]; other site 639283003756 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 639283003757 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 639283003758 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283003759 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283003760 substrate binding pocket [chemical binding]; other site 639283003761 membrane-bound complex binding site; other site 639283003762 hinge residues; other site 639283003763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283003764 dimer interface [polypeptide binding]; other site 639283003765 conserved gate region; other site 639283003766 putative PBP binding loops; other site 639283003767 ABC-ATPase subunit interface; other site 639283003768 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283003769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 639283003770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283003771 ABC-ATPase subunit interface; other site 639283003772 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283003773 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 639283003774 Walker A/P-loop; other site 639283003775 ATP binding site [chemical binding]; other site 639283003776 Q-loop/lid; other site 639283003777 ABC transporter signature motif; other site 639283003778 Walker B; other site 639283003779 D-loop; other site 639283003780 H-loop/switch region; other site 639283003781 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 639283003782 Transposase; Region: HTH_Tnp_1; pfam01527 639283003783 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 639283003784 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 639283003785 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 639283003786 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 639283003787 catalytic residues [active] 639283003788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283003789 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283003790 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 639283003791 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 639283003792 catalytic residues [active] 639283003793 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 639283003794 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 639283003795 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 639283003796 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283003797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283003798 active site 639283003799 phosphorylation site [posttranslational modification] 639283003800 intermolecular recognition site; other site 639283003801 dimerization interface [polypeptide binding]; other site 639283003802 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283003803 DNA binding site [nucleotide binding] 639283003804 sensor protein QseC; Provisional; Region: PRK10337 639283003805 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 639283003806 dimer interface [polypeptide binding]; other site 639283003807 phosphorylation site [posttranslational modification] 639283003808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283003809 ATP binding site [chemical binding]; other site 639283003810 Mg2+ binding site [ion binding]; other site 639283003811 G-X-G motif; other site 639283003812 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 639283003813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283003814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283003815 dimerization interface [polypeptide binding]; other site 639283003816 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 639283003817 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 639283003818 tetramerization interface [polypeptide binding]; other site 639283003819 NAD(P) binding site [chemical binding]; other site 639283003820 catalytic residues [active] 639283003821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283003822 short chain dehydrogenase; Provisional; Region: PRK12939 639283003823 NAD(P) binding site [chemical binding]; other site 639283003824 active site 639283003825 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 639283003826 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 639283003827 potential catalytic triad [active] 639283003828 conserved cys residue [active] 639283003829 Oxygen tolerance; Region: BatD; pfam13584 639283003830 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 639283003831 metal ion-dependent adhesion site (MIDAS); other site 639283003832 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 639283003833 metal ion-dependent adhesion site (MIDAS); other site 639283003834 Protein of unknown function DUF58; Region: DUF58; pfam01882 639283003835 MoxR-like ATPases [General function prediction only]; Region: COG0714 639283003836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283003837 Walker A motif; other site 639283003838 ATP binding site [chemical binding]; other site 639283003839 Walker B motif; other site 639283003840 arginine finger; other site 639283003841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 639283003842 HAMP domain; Region: HAMP; pfam00672 639283003843 dimerization interface [polypeptide binding]; other site 639283003844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 639283003845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283003846 active site 639283003847 phosphorylation site [posttranslational modification] 639283003848 intermolecular recognition site; other site 639283003849 dimerization interface [polypeptide binding]; other site 639283003850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283003851 DNA binding residues [nucleotide binding] 639283003852 dimerization interface [polypeptide binding]; other site 639283003853 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283003854 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283003855 metal binding site [ion binding]; metal-binding site 639283003856 active site 639283003857 I-site; other site 639283003858 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 639283003859 Domain of unknown function DUF20; Region: UPF0118; pfam01594 639283003860 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 639283003861 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 639283003862 Nitrogen regulatory protein P-II; Region: P-II; smart00938 639283003863 Nitrogen regulatory protein P-II; Region: P-II; cl00412 639283003864 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 639283003865 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 639283003866 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 639283003867 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 639283003868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283003869 motif II; other site 639283003870 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 639283003871 AAA domain; Region: AAA_22; pfam13401 639283003872 Integrase core domain; Region: rve; pfam00665 639283003873 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 639283003874 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 639283003875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 639283003876 non-specific DNA binding site [nucleotide binding]; other site 639283003877 salt bridge; other site 639283003878 sequence-specific DNA binding site [nucleotide binding]; other site 639283003879 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 639283003880 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 639283003881 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 639283003882 putative hydrophobic ligand binding site [chemical binding]; other site 639283003883 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 639283003884 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 639283003885 Flavoprotein; Region: Flavoprotein; pfam02441 639283003886 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 639283003887 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 639283003888 ATP binding site [chemical binding]; other site 639283003889 Mg++ binding site [ion binding]; other site 639283003890 motif III; other site 639283003891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 639283003892 nucleotide binding region [chemical binding]; other site 639283003893 ATP-binding site [chemical binding]; other site 639283003894 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 639283003895 RNA binding site [nucleotide binding]; other site 639283003896 PBP superfamily domain; Region: PBP_like_2; cl17296 639283003897 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283003898 dimerization interface [polypeptide binding]; other site 639283003899 putative DNA binding site [nucleotide binding]; other site 639283003900 putative Zn2+ binding site [ion binding]; other site 639283003901 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 639283003902 Low molecular weight phosphatase family; Region: LMWPc; cd00115 639283003903 active site 639283003904 Sodium Bile acid symporter family; Region: SBF; cl17470 639283003905 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 639283003906 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 639283003907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283003908 dimerization interface [polypeptide binding]; other site 639283003909 putative DNA binding site [nucleotide binding]; other site 639283003910 putative Zn2+ binding site [ion binding]; other site 639283003911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 639283003912 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 639283003913 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 639283003914 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 639283003915 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 639283003916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283003917 FeS/SAM binding site; other site 639283003918 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 639283003919 Arsenite oxidase (Arsenite-Ox) oxidizes arsenite to the less toxic arsenate; it transfers the electrons obtained from the oxidation of arsenite towards the soluble periplasmic electron carriers cytochrome c and/or amicyanin. Arsenite oxidase is a...; Region: MopB_Arsenite-Ox; cd02756 639283003920 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 639283003921 [3Fe-4S] binding site [ion binding]; other site 639283003922 molybdopterin cofactor binding site [chemical binding]; other site 639283003923 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 639283003924 molybdopterin cofactor binding site; other site 639283003925 Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase...; Region: Rieske_ArOX_small; cd03476 639283003926 [2Fe-2S] cluster binding site [ion binding]; other site 639283003927 subunit interaction site [polypeptide binding]; other site 639283003928 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 639283003929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283003930 active site 639283003931 phosphorylation site [posttranslational modification] 639283003932 intermolecular recognition site; other site 639283003933 dimerization interface [polypeptide binding]; other site 639283003934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283003935 Walker A motif; other site 639283003936 ATP binding site [chemical binding]; other site 639283003937 Walker B motif; other site 639283003938 arginine finger; other site 639283003939 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 639283003940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283003941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 639283003942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283003943 ATP binding site [chemical binding]; other site 639283003944 G-X-G motif; other site 639283003945 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 639283003946 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 639283003947 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 639283003948 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 639283003949 Uncharacterized conserved protein [Function unknown]; Region: COG2135 639283003950 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 639283003951 dimerization interface [polypeptide binding]; other site 639283003952 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283003953 metal binding site [ion binding]; metal-binding site 639283003954 active site 639283003955 I-site; other site 639283003956 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283003957 Predicted amidohydrolase [General function prediction only]; Region: COG0388 639283003958 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 639283003959 active site 639283003960 catalytic triad [active] 639283003961 dimer interface [polypeptide binding]; other site 639283003962 short chain dehydrogenase; Provisional; Region: PRK06180 639283003963 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 639283003964 NADP binding site [chemical binding]; other site 639283003965 active site 639283003966 steroid binding site; other site 639283003967 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 639283003968 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 639283003969 NAD(P) binding site [chemical binding]; other site 639283003970 SnoaL-like domain; Region: SnoaL_4; pfam13577 639283003971 Cupin; Region: Cupin_6; pfam12852 639283003972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283003973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283003974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283003975 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 639283003976 CrcB-like protein; Region: CRCB; cl09114 639283003977 camphor resistance protein CrcB; Provisional; Region: PRK14203 639283003978 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 639283003979 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 639283003980 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 639283003981 Cupin; Region: Cupin_1; smart00835 639283003982 Cupin; Region: Cupin_1; smart00835 639283003983 Uncharacterized conserved protein [Function unknown]; Region: COG3189 639283003984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283003985 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283003986 DNA binding site [nucleotide binding] 639283003987 Predicted ATPase [General function prediction only]; Region: COG3903 639283003988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283003989 putative active site [active] 639283003990 PAS fold; Region: PAS_3; pfam08447 639283003991 heme pocket [chemical binding]; other site 639283003992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283003993 PAS fold; Region: PAS_3; pfam08447 639283003994 putative active site [active] 639283003995 heme pocket [chemical binding]; other site 639283003996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283003997 dimer interface [polypeptide binding]; other site 639283003998 phosphorylation site [posttranslational modification] 639283003999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283004000 ATP binding site [chemical binding]; other site 639283004001 Mg2+ binding site [ion binding]; other site 639283004002 G-X-G motif; other site 639283004003 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 639283004004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 639283004005 Predicted transcriptional regulator [Transcription]; Region: COG1959 639283004006 Transcriptional regulator; Region: Rrf2; pfam02082 639283004007 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 639283004008 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 639283004009 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 639283004010 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 639283004011 active site 639283004012 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 639283004013 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 639283004014 TSCPD domain; Region: TSCPD; pfam12637 639283004015 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 639283004016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283004017 putative substrate translocation pore; other site 639283004018 NADH dehydrogenase; Validated; Region: PRK08183 639283004019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 639283004020 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 639283004021 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 639283004022 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 639283004023 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 639283004024 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 639283004025 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 639283004026 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 639283004027 carboxyltransferase (CT) interaction site; other site 639283004028 biotinylation site [posttranslational modification]; other site 639283004029 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 639283004030 Dehydroquinase class II; Region: DHquinase_II; pfam01220 639283004031 trimer interface [polypeptide binding]; other site 639283004032 active site 639283004033 dimer interface [polypeptide binding]; other site 639283004034 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 639283004035 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 639283004036 catalytic residues [active] 639283004037 Peptidase family M48; Region: Peptidase_M48; cl12018 639283004038 Tetratricopeptide repeat; Region: TPR_16; pfam13432 639283004039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283004040 Tetratricopeptide repeat; Region: TPR_16; pfam13432 639283004041 TPR motif; other site 639283004042 binding surface 639283004043 aspartate aminotransferase; Provisional; Region: PRK05764 639283004044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283004045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283004046 homodimer interface [polypeptide binding]; other site 639283004047 catalytic residue [active] 639283004048 Predicted transcriptional regulators [Transcription]; Region: COG1733 639283004049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283004050 dimerization interface [polypeptide binding]; other site 639283004051 putative DNA binding site [nucleotide binding]; other site 639283004052 putative Zn2+ binding site [ion binding]; other site 639283004053 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 639283004054 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 639283004055 NADP binding site [chemical binding]; other site 639283004056 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 639283004057 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 639283004058 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 639283004059 AMIN domain; Region: AMIN; pfam11741 639283004060 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 639283004061 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 639283004062 active site 639283004063 metal binding site [ion binding]; metal-binding site 639283004064 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 639283004065 Transglycosylase; Region: Transgly; pfam00912 639283004066 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 639283004067 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 639283004068 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 639283004069 C-terminal domain interface [polypeptide binding]; other site 639283004070 GSH binding site (G-site) [chemical binding]; other site 639283004071 dimer interface [polypeptide binding]; other site 639283004072 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 639283004073 dimer interface [polypeptide binding]; other site 639283004074 N-terminal domain interface [polypeptide binding]; other site 639283004075 putative substrate binding pocket (H-site) [chemical binding]; other site 639283004076 peptide chain release factor 2; Validated; Region: prfB; PRK00578 639283004077 This domain is found in peptide chain release factors; Region: PCRF; smart00937 639283004078 RF-1 domain; Region: RF-1; pfam00472 639283004079 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 639283004080 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 639283004081 catalytic triad [active] 639283004082 Protein of unknown function; Region: DUF3971; pfam13116 639283004083 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 639283004084 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 639283004085 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 639283004086 active site 639283004087 HIGH motif; other site 639283004088 dimer interface [polypeptide binding]; other site 639283004089 KMSKS motif; other site 639283004090 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 639283004091 RNA binding surface [nucleotide binding]; other site 639283004092 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 639283004093 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 639283004094 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 639283004095 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 639283004096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283004097 catalytic residue [active] 639283004098 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 639283004099 putative ABC transporter; Region: ycf24; CHL00085 639283004100 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 639283004101 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 639283004102 Walker A/P-loop; other site 639283004103 ATP binding site [chemical binding]; other site 639283004104 Q-loop/lid; other site 639283004105 ABC transporter signature motif; other site 639283004106 Walker B; other site 639283004107 D-loop; other site 639283004108 H-loop/switch region; other site 639283004109 FeS assembly protein SufD; Region: sufD; TIGR01981 639283004110 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 639283004111 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 639283004112 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 639283004113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283004114 catalytic residue [active] 639283004115 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 639283004116 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283004117 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 639283004118 putative metal binding site [ion binding]; other site 639283004119 Uncharacterized conserved protein [Function unknown]; Region: COG3791 639283004120 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 639283004121 TfoX N-terminal domain; Region: TfoX_N; pfam04993 639283004122 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 639283004123 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 639283004124 ATP binding site [chemical binding]; other site 639283004125 Mg++ binding site [ion binding]; other site 639283004126 motif III; other site 639283004127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 639283004128 nucleotide binding region [chemical binding]; other site 639283004129 ATP-binding site [chemical binding]; other site 639283004130 transcription elongation factor regulatory protein; Validated; Region: PRK06342 639283004131 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 639283004132 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 639283004133 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 639283004134 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 639283004135 active site 639283004136 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 639283004137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 639283004138 active site 639283004139 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 639283004140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283004141 Mg2+ binding site [ion binding]; other site 639283004142 G-X-G motif; other site 639283004143 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 639283004144 anchoring element; other site 639283004145 dimer interface [polypeptide binding]; other site 639283004146 ATP binding site [chemical binding]; other site 639283004147 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 639283004148 active site 639283004149 metal binding site [ion binding]; metal-binding site 639283004150 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 639283004151 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 639283004152 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 639283004153 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 639283004154 active site clefts [active] 639283004155 zinc binding site [ion binding]; other site 639283004156 dimer interface [polypeptide binding]; other site 639283004157 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 639283004158 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 639283004159 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 639283004160 aminotransferase; Validated; Region: PRK09148 639283004161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283004162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283004163 homodimer interface [polypeptide binding]; other site 639283004164 catalytic residue [active] 639283004165 homoserine dehydrogenase; Provisional; Region: PRK06349 639283004166 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 639283004167 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 639283004168 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 639283004169 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 639283004170 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 639283004171 putative active site [active] 639283004172 putative hydrolase; Provisional; Region: PRK11460 639283004173 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 639283004174 EamA-like transporter family; Region: EamA; pfam00892 639283004175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 639283004176 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 639283004177 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 639283004178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283004179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283004180 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 639283004181 DHH family; Region: DHH; pfam01368 639283004182 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 639283004183 Imelysin; Region: Peptidase_M75; cl09159 639283004184 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 639283004185 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 639283004186 Multicopper oxidase; Region: Cu-oxidase; pfam00394 639283004187 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 639283004188 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 639283004189 Imelysin; Region: Peptidase_M75; cl09159 639283004190 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 639283004191 hypothetical protein; Provisional; Region: PRK08912 639283004192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283004193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283004194 homodimer interface [polypeptide binding]; other site 639283004195 catalytic residue [active] 639283004196 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283004197 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 639283004198 putative ligand binding site [chemical binding]; other site 639283004199 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283004200 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283004201 TM-ABC transporter signature motif; other site 639283004202 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283004203 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283004204 TM-ABC transporter signature motif; other site 639283004205 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 639283004206 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283004207 Walker A/P-loop; other site 639283004208 ATP binding site [chemical binding]; other site 639283004209 Q-loop/lid; other site 639283004210 ABC transporter signature motif; other site 639283004211 Walker B; other site 639283004212 D-loop; other site 639283004213 H-loop/switch region; other site 639283004214 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 639283004215 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283004216 Walker A/P-loop; other site 639283004217 ATP binding site [chemical binding]; other site 639283004218 Q-loop/lid; other site 639283004219 ABC transporter signature motif; other site 639283004220 Walker B; other site 639283004221 D-loop; other site 639283004222 H-loop/switch region; other site 639283004223 UreD urease accessory protein; Region: UreD; pfam01774 639283004224 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 639283004225 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 639283004226 alpha-gamma subunit interface [polypeptide binding]; other site 639283004227 beta-gamma subunit interface [polypeptide binding]; other site 639283004228 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 639283004229 alpha-beta subunit interface [polypeptide binding]; other site 639283004230 urease subunit alpha; Reviewed; Region: ureC; PRK13207 639283004231 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 639283004232 subunit interactions [polypeptide binding]; other site 639283004233 active site 639283004234 flap region; other site 639283004235 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 639283004236 dimer interface [polypeptide binding]; other site 639283004237 catalytic residues [active] 639283004238 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 639283004239 UreF; Region: UreF; pfam01730 639283004240 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 639283004241 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 639283004242 GAF domain; Region: GAF; pfam01590 639283004243 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283004244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283004245 metal binding site [ion binding]; metal-binding site 639283004246 active site 639283004247 I-site; other site 639283004248 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283004249 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 639283004250 cystathionine beta-lyase; Provisional; Region: PRK05967 639283004251 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 639283004252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283004253 catalytic residue [active] 639283004254 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 639283004255 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283004256 substrate binding pocket [chemical binding]; other site 639283004257 membrane-bound complex binding site; other site 639283004258 hinge residues; other site 639283004259 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 639283004260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283004261 conserved gate region; other site 639283004262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283004263 dimer interface [polypeptide binding]; other site 639283004264 conserved gate region; other site 639283004265 putative PBP binding loops; other site 639283004266 ABC-ATPase subunit interface; other site 639283004267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283004268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283004269 dimer interface [polypeptide binding]; other site 639283004270 conserved gate region; other site 639283004271 putative PBP binding loops; other site 639283004272 ABC-ATPase subunit interface; other site 639283004273 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283004274 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 639283004275 Walker A/P-loop; other site 639283004276 ATP binding site [chemical binding]; other site 639283004277 Q-loop/lid; other site 639283004278 ABC transporter signature motif; other site 639283004279 Walker B; other site 639283004280 D-loop; other site 639283004281 H-loop/switch region; other site 639283004282 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 639283004283 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 639283004284 active site residue [active] 639283004285 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 639283004286 active site residue [active] 639283004287 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 639283004288 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 639283004289 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 639283004290 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 639283004291 dimer interface [polypeptide binding]; other site 639283004292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283004293 catalytic residue [active] 639283004294 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 639283004295 DNA photolyase; Region: DNA_photolyase; pfam00875 639283004296 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 639283004297 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 639283004298 P-loop; other site 639283004299 Magnesium ion binding site [ion binding]; other site 639283004300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283004301 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283004302 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 639283004303 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 639283004304 putative FMN binding site [chemical binding]; other site 639283004305 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 639283004306 ATP-NAD kinase; Region: NAD_kinase; pfam01513 639283004307 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 639283004308 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 639283004309 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 639283004310 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 639283004311 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 639283004312 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283004313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283004314 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 639283004315 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 639283004316 N-acetyl-D-glucosamine binding site [chemical binding]; other site 639283004317 catalytic residue [active] 639283004318 Sporulation related domain; Region: SPOR; pfam05036 639283004319 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 639283004320 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 639283004321 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 639283004322 Moco binding site; other site 639283004323 metal coordination site [ion binding]; other site 639283004324 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 639283004325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283004326 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 639283004327 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 639283004328 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 639283004329 ligand binding site [chemical binding]; other site 639283004330 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 639283004331 homotrimer interaction site [polypeptide binding]; other site 639283004332 putative active site [active] 639283004333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283004334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283004335 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 639283004336 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 639283004337 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 639283004338 elongation factor Tu; Reviewed; Region: PRK00049 639283004339 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 639283004340 G1 box; other site 639283004341 GEF interaction site [polypeptide binding]; other site 639283004342 GTP/Mg2+ binding site [chemical binding]; other site 639283004343 Switch I region; other site 639283004344 G2 box; other site 639283004345 G3 box; other site 639283004346 Switch II region; other site 639283004347 G4 box; other site 639283004348 G5 box; other site 639283004349 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 639283004350 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 639283004351 Antibiotic Binding Site [chemical binding]; other site 639283004352 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 639283004353 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 639283004354 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 639283004355 putative homodimer interface [polypeptide binding]; other site 639283004356 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 639283004357 heterodimer interface [polypeptide binding]; other site 639283004358 homodimer interface [polypeptide binding]; other site 639283004359 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 639283004360 intracellular protease, PfpI family; Region: PfpI; TIGR01382 639283004361 conserved cys residue [active] 639283004362 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 639283004363 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 639283004364 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 639283004365 23S rRNA interface [nucleotide binding]; other site 639283004366 L7/L12 interface [polypeptide binding]; other site 639283004367 putative thiostrepton binding site; other site 639283004368 L25 interface [polypeptide binding]; other site 639283004369 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 639283004370 mRNA/rRNA interface [nucleotide binding]; other site 639283004371 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 639283004372 23S rRNA interface [nucleotide binding]; other site 639283004373 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 639283004374 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 639283004375 L11 interface [polypeptide binding]; other site 639283004376 putative EF-Tu interaction site [polypeptide binding]; other site 639283004377 putative EF-G interaction site [polypeptide binding]; other site 639283004378 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 639283004379 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 639283004380 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 639283004381 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 639283004382 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 639283004383 RPB11 interaction site [polypeptide binding]; other site 639283004384 RPB12 interaction site [polypeptide binding]; other site 639283004385 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 639283004386 RPB3 interaction site [polypeptide binding]; other site 639283004387 RPB1 interaction site [polypeptide binding]; other site 639283004388 RPB11 interaction site [polypeptide binding]; other site 639283004389 RPB10 interaction site [polypeptide binding]; other site 639283004390 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 639283004391 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 639283004392 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 639283004393 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 639283004394 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 639283004395 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 639283004396 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 639283004397 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 639283004398 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 639283004399 DNA binding site [nucleotide binding] 639283004400 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 639283004401 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 639283004402 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 639283004403 protein binding site [polypeptide binding]; other site 639283004404 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 639283004405 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 639283004406 MarR family; Region: MarR_2; cl17246 639283004407 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 639283004408 S17 interaction site [polypeptide binding]; other site 639283004409 S8 interaction site; other site 639283004410 16S rRNA interaction site [nucleotide binding]; other site 639283004411 streptomycin interaction site [chemical binding]; other site 639283004412 23S rRNA interaction site [nucleotide binding]; other site 639283004413 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 639283004414 30S ribosomal protein S7; Validated; Region: PRK05302 639283004415 elongation factor G; Reviewed; Region: PRK00007 639283004416 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 639283004417 G1 box; other site 639283004418 putative GEF interaction site [polypeptide binding]; other site 639283004419 GTP/Mg2+ binding site [chemical binding]; other site 639283004420 Switch I region; other site 639283004421 G2 box; other site 639283004422 G3 box; other site 639283004423 Switch II region; other site 639283004424 G4 box; other site 639283004425 G5 box; other site 639283004426 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 639283004427 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 639283004428 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 639283004429 elongation factor Tu; Reviewed; Region: PRK00049 639283004430 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 639283004431 G1 box; other site 639283004432 GEF interaction site [polypeptide binding]; other site 639283004433 GTP/Mg2+ binding site [chemical binding]; other site 639283004434 Switch I region; other site 639283004435 G2 box; other site 639283004436 G3 box; other site 639283004437 Switch II region; other site 639283004438 G4 box; other site 639283004439 G5 box; other site 639283004440 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 639283004441 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 639283004442 Antibiotic Binding Site [chemical binding]; other site 639283004443 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 639283004444 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 639283004445 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 639283004446 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 639283004447 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 639283004448 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 639283004449 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 639283004450 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 639283004451 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 639283004452 putative translocon binding site; other site 639283004453 protein-rRNA interface [nucleotide binding]; other site 639283004454 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 639283004455 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 639283004456 G-X-X-G motif; other site 639283004457 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 639283004458 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 639283004459 23S rRNA interface [nucleotide binding]; other site 639283004460 5S rRNA interface [nucleotide binding]; other site 639283004461 putative antibiotic binding site [chemical binding]; other site 639283004462 L25 interface [polypeptide binding]; other site 639283004463 L27 interface [polypeptide binding]; other site 639283004464 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 639283004465 23S rRNA interface [nucleotide binding]; other site 639283004466 putative translocon interaction site; other site 639283004467 signal recognition particle (SRP54) interaction site; other site 639283004468 L23 interface [polypeptide binding]; other site 639283004469 trigger factor interaction site; other site 639283004470 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 639283004471 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 639283004472 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 639283004473 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 639283004474 RNA binding site [nucleotide binding]; other site 639283004475 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 639283004476 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 639283004477 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 639283004478 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 639283004479 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 639283004480 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 639283004481 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 639283004482 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 639283004483 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 639283004484 5S rRNA interface [nucleotide binding]; other site 639283004485 23S rRNA interface [nucleotide binding]; other site 639283004486 L5 interface [polypeptide binding]; other site 639283004487 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 639283004488 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 639283004489 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 639283004490 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 639283004491 23S rRNA binding site [nucleotide binding]; other site 639283004492 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 639283004493 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 639283004494 SecY translocase; Region: SecY; pfam00344 639283004495 adenylate kinase; Reviewed; Region: adk; PRK00279 639283004496 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 639283004497 AMP-binding site [chemical binding]; other site 639283004498 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 639283004499 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 639283004500 30S ribosomal protein S13; Region: bact_S13; TIGR03631 639283004501 30S ribosomal protein S11; Validated; Region: PRK05309 639283004502 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 639283004503 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 639283004504 alphaNTD - beta interaction site [polypeptide binding]; other site 639283004505 alphaNTD homodimer interface [polypeptide binding]; other site 639283004506 alphaNTD - beta' interaction site [polypeptide binding]; other site 639283004507 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 639283004508 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 639283004509 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 639283004510 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 639283004511 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 639283004512 protein binding site [polypeptide binding]; other site 639283004513 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 639283004514 protein binding site [polypeptide binding]; other site 639283004515 recombination factor protein RarA; Reviewed; Region: PRK13342 639283004516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283004517 Walker A motif; other site 639283004518 ATP binding site [chemical binding]; other site 639283004519 Walker B motif; other site 639283004520 arginine finger; other site 639283004521 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 639283004522 camphor resistance protein CrcB; Provisional; Region: PRK14198 639283004523 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 639283004524 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 639283004525 RNA binding surface [nucleotide binding]; other site 639283004526 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 639283004527 active site 639283004528 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 639283004529 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 639283004530 NodB motif; other site 639283004531 active site 639283004532 catalytic site [active] 639283004533 metal binding site [ion binding]; metal-binding site 639283004534 lipoate-protein ligase B; Provisional; Region: PRK14341 639283004535 Acylphosphatase; Region: Acylphosphatase; pfam00708 639283004536 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 639283004537 MgtE intracellular N domain; Region: MgtE_N; smart00924 639283004538 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 639283004539 Divalent cation transporter; Region: MgtE; cl00786 639283004540 CHASE4 domain; Region: CHASE4; pfam05228 639283004541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283004542 metal binding site [ion binding]; metal-binding site 639283004543 active site 639283004544 I-site; other site 639283004545 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283004546 Uncharacterized conserved protein [Function unknown]; Region: COG1434 639283004547 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 639283004548 putative active site [active] 639283004549 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 639283004550 Protein of unknown function, DUF599; Region: DUF599; pfam04654 639283004551 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 639283004552 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 639283004553 putative C-terminal domain interface [polypeptide binding]; other site 639283004554 putative GSH binding site (G-site) [chemical binding]; other site 639283004555 putative dimer interface [polypeptide binding]; other site 639283004556 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 639283004557 putative N-terminal domain interface [polypeptide binding]; other site 639283004558 putative dimer interface [polypeptide binding]; other site 639283004559 putative substrate binding pocket (H-site) [chemical binding]; other site 639283004560 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 639283004561 pantoate--beta-alanine ligase; Region: panC; TIGR00018 639283004562 Pantoate-beta-alanine ligase; Region: PanC; cd00560 639283004563 active site 639283004564 ATP-binding site [chemical binding]; other site 639283004565 pantoate-binding site; other site 639283004566 HXXH motif; other site 639283004567 von Willebrand factor type A domain; Region: VWA_2; pfam13519 639283004568 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 639283004569 HSP70 interaction site [polypeptide binding]; other site 639283004570 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 639283004571 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 639283004572 Sporulation related domain; Region: SPOR; pfam05036 639283004573 Phasin protein; Region: Phasin_2; pfam09361 639283004574 Uncharacterized conserved protein [Function unknown]; Region: COG2127 639283004575 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 639283004576 Clp amino terminal domain; Region: Clp_N; pfam02861 639283004577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283004578 Walker A motif; other site 639283004579 ATP binding site [chemical binding]; other site 639283004580 Walker B motif; other site 639283004581 arginine finger; other site 639283004582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283004583 Walker A motif; other site 639283004584 ATP binding site [chemical binding]; other site 639283004585 Walker B motif; other site 639283004586 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 639283004587 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 639283004588 HIT family signature motif; other site 639283004589 catalytic residue [active] 639283004590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 639283004591 Protein of unknown function, DUF482; Region: DUF482; pfam04339 639283004592 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 639283004593 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 639283004594 active site 639283004595 catalytic site [active] 639283004596 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 639283004597 homotrimer interaction site [polypeptide binding]; other site 639283004598 putative active site [active] 639283004599 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 639283004600 DNA polymerase IV; Provisional; Region: PRK02794 639283004601 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 639283004602 active site 639283004603 DNA binding site [nucleotide binding] 639283004604 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 639283004605 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 639283004606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283004607 active site 639283004608 phosphorylation site [posttranslational modification] 639283004609 intermolecular recognition site; other site 639283004610 dimerization interface [polypeptide binding]; other site 639283004611 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 639283004612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283004613 putative substrate translocation pore; other site 639283004614 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 639283004615 nudix motif; other site 639283004616 Protein of unknown function (DUF983); Region: DUF983; cl02211 639283004617 ribonuclease R; Region: RNase_R; TIGR02063 639283004618 RNB domain; Region: RNB; pfam00773 639283004619 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 639283004620 RNA binding site [nucleotide binding]; other site 639283004621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283004622 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 639283004623 putative substrate translocation pore; other site 639283004624 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 639283004625 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 639283004626 active site 639283004627 interdomain interaction site; other site 639283004628 putative metal-binding site [ion binding]; other site 639283004629 nucleotide binding site [chemical binding]; other site 639283004630 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 639283004631 domain I; other site 639283004632 DNA binding groove [nucleotide binding] 639283004633 phosphate binding site [ion binding]; other site 639283004634 domain II; other site 639283004635 domain III; other site 639283004636 nucleotide binding site [chemical binding]; other site 639283004637 catalytic site [active] 639283004638 domain IV; other site 639283004639 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 639283004640 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 639283004641 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 639283004642 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 639283004643 DNA protecting protein DprA; Region: dprA; TIGR00732 639283004644 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 639283004645 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 639283004646 dihydroorotase; Validated; Region: PRK09059 639283004647 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283004648 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 639283004649 active site 639283004650 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 639283004651 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 639283004652 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 639283004653 Predicted permeases [General function prediction only]; Region: COG0679 639283004654 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 639283004655 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 639283004656 metal-dependent hydrolase; Provisional; Region: PRK00685 639283004657 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 639283004658 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 639283004659 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 639283004660 Chorismate mutase type II; Region: CM_2; smart00830 639283004661 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 639283004662 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 639283004663 tetramer interface [polypeptide binding]; other site 639283004664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283004665 catalytic residue [active] 639283004666 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 639283004667 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 639283004668 GatB domain; Region: GatB_Yqey; smart00845 639283004669 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 639283004670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283004671 Coenzyme A binding pocket [chemical binding]; other site 639283004672 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 639283004673 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 639283004674 C-terminal domain interface [polypeptide binding]; other site 639283004675 GSH binding site (G-site) [chemical binding]; other site 639283004676 dimer interface [polypeptide binding]; other site 639283004677 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 639283004678 N-terminal domain interface [polypeptide binding]; other site 639283004679 putative dimer interface [polypeptide binding]; other site 639283004680 active site 639283004681 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 639283004682 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 639283004683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283004684 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 639283004685 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 639283004686 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 639283004687 Soluble P-type ATPase [General function prediction only]; Region: COG4087 639283004688 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 639283004689 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 639283004690 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 639283004691 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 639283004692 Ligand Binding Site [chemical binding]; other site 639283004693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283004694 dimer interface [polypeptide binding]; other site 639283004695 phosphorylation site [posttranslational modification] 639283004696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283004697 ATP binding site [chemical binding]; other site 639283004698 Mg2+ binding site [ion binding]; other site 639283004699 G-X-G motif; other site 639283004700 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 639283004701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283004702 active site 639283004703 phosphorylation site [posttranslational modification] 639283004704 intermolecular recognition site; other site 639283004705 dimerization interface [polypeptide binding]; other site 639283004706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283004707 DNA binding site [nucleotide binding] 639283004708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283004709 metabolite-proton symporter; Region: 2A0106; TIGR00883 639283004710 putative substrate translocation pore; other site 639283004711 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 639283004712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283004713 putative substrate translocation pore; other site 639283004714 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 639283004715 Predicted amidohydrolase [General function prediction only]; Region: COG0388 639283004716 putative active site [active] 639283004717 catalytic triad [active] 639283004718 putative dimer interface [polypeptide binding]; other site 639283004719 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 639283004720 agmatinase; Region: agmatinase; TIGR01230 639283004721 oligomer interface [polypeptide binding]; other site 639283004722 putative active site [active] 639283004723 Mn binding site [ion binding]; other site 639283004724 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 639283004725 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283004726 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 639283004727 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 639283004728 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 639283004729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 639283004730 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 639283004731 putative deacylase active site [active] 639283004732 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 639283004733 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 639283004734 gating phenylalanine in ion channel; other site 639283004735 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 639283004736 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 639283004737 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283004738 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 639283004739 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 639283004740 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 639283004741 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 639283004742 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 639283004743 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283004744 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283004745 TM-ABC transporter signature motif; other site 639283004746 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283004747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283004748 TM-ABC transporter signature motif; other site 639283004749 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 639283004750 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 639283004751 Walker A/P-loop; other site 639283004752 ATP binding site [chemical binding]; other site 639283004753 Q-loop/lid; other site 639283004754 ABC transporter signature motif; other site 639283004755 Walker B; other site 639283004756 D-loop; other site 639283004757 H-loop/switch region; other site 639283004758 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 639283004759 TMAO reductase system periplasmic protein TorT; Region: TMAO_TorT; TIGR02955 639283004760 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 639283004761 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 639283004762 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 639283004763 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 639283004764 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 639283004765 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 639283004766 aminotransferase; Provisional; Region: PRK06105 639283004767 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 639283004768 inhibitor-cofactor binding pocket; inhibition site 639283004769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283004770 catalytic residue [active] 639283004771 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283004772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283004773 Aspergillus nidulans lactam utilization protein LamB and similar proteins; Region: LamB_like; cd11665 639283004774 putative active site [active] 639283004775 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283004776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283004777 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 639283004778 putative substrate binding pocket [chemical binding]; other site 639283004779 dimerization interface [polypeptide binding]; other site 639283004780 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 639283004781 carboxyltransferase (CT) interaction site; other site 639283004782 biotinylation site [posttranslational modification]; other site 639283004783 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 639283004784 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 639283004785 ATP-grasp domain; Region: ATP-grasp_4; cl17255 639283004786 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 639283004787 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 639283004788 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 639283004789 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 639283004790 DctM-like transporters; Region: DctM; pfam06808 639283004791 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 639283004792 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 639283004793 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 639283004794 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 639283004795 malonyl-CoA synthase; Validated; Region: PRK07514 639283004796 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 639283004797 acyl-activating enzyme (AAE) consensus motif; other site 639283004798 active site 639283004799 AMP binding site [chemical binding]; other site 639283004800 CoA binding site [chemical binding]; other site 639283004801 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 639283004802 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283004803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283004804 DNA-binding site [nucleotide binding]; DNA binding site 639283004805 FCD domain; Region: FCD; pfam07729 639283004806 pyrimidine utilization protein D; Region: RutD; TIGR03611 639283004807 Serine hydrolase; Region: Ser_hydrolase; cl17834 639283004808 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 639283004809 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 639283004810 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 639283004811 Sodium Bile acid symporter family; Region: SBF; cl17470 639283004812 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 639283004813 ArsC family; Region: ArsC; pfam03960 639283004814 catalytic residues [active] 639283004815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283004816 Coenzyme A binding pocket [chemical binding]; other site 639283004817 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 639283004818 Low molecular weight phosphatase family; Region: LMWPc; cd00115 639283004819 active site 639283004820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283004821 dimerization interface [polypeptide binding]; other site 639283004822 putative DNA binding site [nucleotide binding]; other site 639283004823 putative Zn2+ binding site [ion binding]; other site 639283004824 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 639283004825 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 639283004826 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283004827 DNA-binding site [nucleotide binding]; DNA binding site 639283004828 FCD domain; Region: FCD; pfam07729 639283004829 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 639283004830 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 639283004831 active site residue [active] 639283004832 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 639283004833 active site residue [active] 639283004834 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 639283004835 active site residue [active] 639283004836 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 639283004837 active site residue [active] 639283004838 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 639283004839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283004840 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 639283004841 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 639283004842 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 639283004843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283004844 NAD(P) binding site [chemical binding]; other site 639283004845 active site 639283004846 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 639283004847 tartrate dehydrogenase; Provisional; Region: PRK08194 639283004848 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 639283004849 tartrate dehydrogenase; Region: TTC; TIGR02089 639283004850 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 639283004851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283004852 DNA-binding site [nucleotide binding]; DNA binding site 639283004853 FCD domain; Region: FCD; pfam07729 639283004854 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 639283004855 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 639283004856 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 639283004857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283004858 DNA-binding site [nucleotide binding]; DNA binding site 639283004859 FCD domain; Region: FCD; pfam07729 639283004860 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 639283004861 tartrate dehydrogenase; Region: TTC; TIGR02089 639283004862 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 639283004863 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 639283004864 dimer interface [polypeptide binding]; other site 639283004865 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283004866 active site 639283004867 metal binding site [ion binding]; metal-binding site 639283004868 glutathione binding site [chemical binding]; other site 639283004869 NAD-dependent deacetylase; Provisional; Region: PRK00481 639283004870 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 639283004871 NAD+ binding site [chemical binding]; other site 639283004872 substrate binding site [chemical binding]; other site 639283004873 Zn binding site [ion binding]; other site 639283004874 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 639283004875 DNA-binding site [nucleotide binding]; DNA binding site 639283004876 RNA-binding motif; other site 639283004877 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 639283004878 DNA-binding site [nucleotide binding]; DNA binding site 639283004879 RNA-binding motif; other site 639283004880 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 639283004881 ATP-grasp domain; Region: ATP-grasp_4; cl17255 639283004882 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 639283004883 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 639283004884 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 639283004885 ligand binding site [chemical binding]; other site 639283004886 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 639283004887 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 639283004888 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 639283004889 L-ascorbate oxidase, fungal type; Region: ascorbOXfungal; TIGR03390 639283004890 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 639283004891 Multicopper oxidase; Region: Cu-oxidase; pfam00394 639283004892 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 639283004893 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 639283004894 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 639283004895 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 639283004896 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 639283004897 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 639283004898 ligand binding site [chemical binding]; other site 639283004899 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 639283004900 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 639283004901 N-acetyl-D-glucosamine binding site [chemical binding]; other site 639283004902 catalytic residue [active] 639283004903 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 639283004904 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 639283004905 dimer interface [polypeptide binding]; other site 639283004906 active site 639283004907 catalytic residue [active] 639283004908 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 639283004909 SmpB-tmRNA interface; other site 639283004910 elongation factor P; Validated; Region: PRK00529 639283004911 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 639283004912 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 639283004913 RNA binding site [nucleotide binding]; other site 639283004914 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 639283004915 RNA binding site [nucleotide binding]; other site 639283004916 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 639283004917 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 639283004918 motif 1; other site 639283004919 dimer interface [polypeptide binding]; other site 639283004920 active site 639283004921 motif 2; other site 639283004922 motif 3; other site 639283004923 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 639283004924 Fe-S cluster binding site [ion binding]; other site 639283004925 DNA binding site [nucleotide binding] 639283004926 active site 639283004927 Uncharacterized conserved protein [Function unknown]; Region: COG1432 639283004928 LabA_like proteins; Region: LabA; cd10911 639283004929 putative metal binding site [ion binding]; other site 639283004930 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 639283004931 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 639283004932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 639283004933 Zn2+ binding site [ion binding]; other site 639283004934 Mg2+ binding site [ion binding]; other site 639283004935 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 639283004936 synthetase active site [active] 639283004937 NTP binding site [chemical binding]; other site 639283004938 metal binding site [ion binding]; metal-binding site 639283004939 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 639283004940 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 639283004941 CsbD-like; Region: CsbD; pfam05532 639283004942 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283004943 active site 639283004944 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 639283004945 active site 639283004946 hydrophilic channel; other site 639283004947 dimerization interface [polypeptide binding]; other site 639283004948 catalytic residues [active] 639283004949 active site lid [active] 639283004950 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 639283004951 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 639283004952 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 639283004953 Catalytic site [active] 639283004954 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 639283004955 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 639283004956 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 639283004957 dimerization interface [polypeptide binding]; other site 639283004958 active site 639283004959 metal binding site [ion binding]; metal-binding site 639283004960 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 639283004961 dsRNA binding site [nucleotide binding]; other site 639283004962 GTPase Era; Reviewed; Region: era; PRK00089 639283004963 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 639283004964 G1 box; other site 639283004965 GTP/Mg2+ binding site [chemical binding]; other site 639283004966 Switch I region; other site 639283004967 G2 box; other site 639283004968 Switch II region; other site 639283004969 G3 box; other site 639283004970 G4 box; other site 639283004971 G5 box; other site 639283004972 KH domain; Region: KH_2; pfam07650 639283004973 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 639283004974 Recombination protein O N terminal; Region: RecO_N; pfam11967 639283004975 Recombination protein O C terminal; Region: RecO_C; pfam02565 639283004976 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 639283004977 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 639283004978 CAP-like domain; other site 639283004979 active site 639283004980 primary dimer interface [polypeptide binding]; other site 639283004981 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 639283004982 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 639283004983 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 639283004984 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 639283004985 RDD family; Region: RDD; pfam06271 639283004986 threonine dehydratase; Provisional; Region: PRK07334 639283004987 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 639283004988 tetramer interface [polypeptide binding]; other site 639283004989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283004990 catalytic residue [active] 639283004991 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 639283004992 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283004993 TM-ABC transporter signature motif; other site 639283004994 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 639283004995 dimer interface [polypeptide binding]; other site 639283004996 allosteric magnesium binding site [ion binding]; other site 639283004997 active site 639283004998 aspartate-rich active site metal binding site; other site 639283004999 Schiff base residues; other site 639283005000 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 639283005001 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 639283005002 substrate binding site [chemical binding]; other site 639283005003 oxyanion hole (OAH) forming residues; other site 639283005004 trimer interface [polypeptide binding]; other site 639283005005 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 639283005006 Transcriptional regulators [Transcription]; Region: MarR; COG1846 639283005007 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 639283005008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283005009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283005010 metal binding site [ion binding]; metal-binding site 639283005011 active site 639283005012 I-site; other site 639283005013 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 639283005014 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 639283005015 active site 639283005016 Zn binding site [ion binding]; other site 639283005017 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 639283005018 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 639283005019 dimer interface [polypeptide binding]; other site 639283005020 active site 639283005021 glycine-pyridoxal phosphate binding site [chemical binding]; other site 639283005022 folate binding site [chemical binding]; other site 639283005023 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 639283005024 ATP cone domain; Region: ATP-cone; pfam03477 639283005025 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 639283005026 catalytic motif [active] 639283005027 Zn binding site [ion binding]; other site 639283005028 RibD C-terminal domain; Region: RibD_C; cl17279 639283005029 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 639283005030 Lumazine binding domain; Region: Lum_binding; pfam00677 639283005031 Lumazine binding domain; Region: Lum_binding; pfam00677 639283005032 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 639283005033 homopentamer interface [polypeptide binding]; other site 639283005034 active site 639283005035 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 639283005036 putative RNA binding site [nucleotide binding]; other site 639283005037 thiamine monophosphate kinase; Provisional; Region: PRK05731 639283005038 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 639283005039 ATP binding site [chemical binding]; other site 639283005040 dimerization interface [polypeptide binding]; other site 639283005041 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 639283005042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283005043 substrate binding pocket [chemical binding]; other site 639283005044 membrane-bound complex binding site; other site 639283005045 hinge residues; other site 639283005046 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 639283005047 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 639283005048 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 639283005049 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 639283005050 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 639283005051 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 639283005052 putative phosphate acyltransferase; Provisional; Region: PRK05331 639283005053 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 639283005054 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 639283005055 dimer interface [polypeptide binding]; other site 639283005056 active site 639283005057 CoA binding pocket [chemical binding]; other site 639283005058 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 639283005059 IHF - DNA interface [nucleotide binding]; other site 639283005060 IHF dimer interface [polypeptide binding]; other site 639283005061 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 639283005062 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 639283005063 DNA binding residues [nucleotide binding] 639283005064 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 639283005065 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 639283005066 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 639283005067 aldehyde dehydrogenase family 7 member; Region: PLN02315 639283005068 tetrameric interface [polypeptide binding]; other site 639283005069 NAD binding site [chemical binding]; other site 639283005070 catalytic residues [active] 639283005071 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 639283005072 putative FMN binding site [chemical binding]; other site 639283005073 AAA domain; Region: AAA_31; pfam13614 639283005074 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 639283005075 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 639283005076 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 639283005077 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 639283005078 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 639283005079 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 639283005080 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 639283005081 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 639283005082 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 639283005083 dimer interface [polypeptide binding]; other site 639283005084 ssDNA binding site [nucleotide binding]; other site 639283005085 tetramer (dimer of dimers) interface [polypeptide binding]; other site 639283005086 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 639283005087 DNA gyrase subunit A; Validated; Region: PRK05560 639283005088 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 639283005089 CAP-like domain; other site 639283005090 active site 639283005091 primary dimer interface [polypeptide binding]; other site 639283005092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 639283005093 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 639283005094 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 639283005095 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 639283005096 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 639283005097 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 639283005098 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 639283005099 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 639283005100 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 639283005101 active site 639283005102 (T/H)XGH motif; other site 639283005103 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 639283005104 active site 639283005105 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 639283005106 active site 639283005107 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 639283005108 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 639283005109 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 639283005110 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 639283005111 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 639283005112 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 639283005113 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 639283005114 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 639283005115 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 639283005116 CPxP motif; other site 639283005117 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 639283005118 Walker A motif; other site 639283005119 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 639283005120 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 639283005121 GTP binding site; other site 639283005122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 639283005123 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 639283005124 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 639283005125 generic binding surface II; other site 639283005126 ssDNA binding site; other site 639283005127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 639283005128 ATP binding site [chemical binding]; other site 639283005129 putative Mg++ binding site [ion binding]; other site 639283005130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 639283005131 ATP-binding site [chemical binding]; other site 639283005132 Uncharacterized conserved protein [Function unknown]; Region: COG2938 639283005133 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 639283005134 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 639283005135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 639283005136 ATP binding site [chemical binding]; other site 639283005137 putative Mg++ binding site [ion binding]; other site 639283005138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 639283005139 nucleotide binding region [chemical binding]; other site 639283005140 ATP-binding site [chemical binding]; other site 639283005141 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 639283005142 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 639283005143 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 639283005144 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 639283005145 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 639283005146 Predicted permeases [General function prediction only]; Region: COG0679 639283005147 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 639283005148 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 639283005149 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 639283005150 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 639283005151 NADP binding site [chemical binding]; other site 639283005152 dimer interface [polypeptide binding]; other site 639283005153 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 639283005154 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 639283005155 Walker A/P-loop; other site 639283005156 ATP binding site [chemical binding]; other site 639283005157 Q-loop/lid; other site 639283005158 ABC transporter signature motif; other site 639283005159 Walker B; other site 639283005160 D-loop; other site 639283005161 H-loop/switch region; other site 639283005162 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 639283005163 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283005164 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 639283005165 TM-ABC transporter signature motif; other site 639283005166 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 639283005167 TM-ABC transporter signature motif; other site 639283005168 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 639283005169 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 639283005170 putative ligand binding site [chemical binding]; other site 639283005171 AAA domain; Region: AAA_21; pfam13304 639283005172 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 639283005173 allantoate amidohydrolase; Reviewed; Region: PRK09290 639283005174 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 639283005175 active site 639283005176 metal binding site [ion binding]; metal-binding site 639283005177 dimer interface [polypeptide binding]; other site 639283005178 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 639283005179 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 639283005180 metal binding site [ion binding]; metal-binding site 639283005181 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 639283005182 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 639283005183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283005184 FeS/SAM binding site; other site 639283005185 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 639283005186 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 639283005187 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 639283005188 N-acetyl-D-glucosamine binding site [chemical binding]; other site 639283005189 catalytic residue [active] 639283005190 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 639283005191 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 639283005192 DctM-like transporters; Region: DctM; pfam06808 639283005193 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 639283005194 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 639283005195 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 639283005196 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 639283005197 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 639283005198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283005199 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 639283005200 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 639283005201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283005202 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 639283005203 putative dimerization interface [polypeptide binding]; other site 639283005204 putative substrate binding pocket [chemical binding]; other site 639283005205 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 639283005206 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283005207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 639283005208 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 639283005209 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283005210 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283005211 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 639283005212 putative dimerization interface [polypeptide binding]; other site 639283005213 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 639283005214 acetoin reductases; Region: 23BDH; TIGR02415 639283005215 putative NAD(P) binding site [chemical binding]; other site 639283005216 putative active site [active] 639283005217 hypothetical protein; Validated; Region: PRK08245 639283005218 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 639283005219 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283005220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283005221 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 639283005222 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 639283005223 active site pocket [active] 639283005224 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 639283005225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283005226 DNA-binding site [nucleotide binding]; DNA binding site 639283005227 FCD domain; Region: FCD; pfam07729 639283005228 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 639283005229 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 639283005230 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 639283005231 substrate binding site [chemical binding]; other site 639283005232 dimer interface [polypeptide binding]; other site 639283005233 ATP binding site [chemical binding]; other site 639283005234 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 639283005235 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283005236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283005237 substrate binding pocket [chemical binding]; other site 639283005238 membrane-bound complex binding site; other site 639283005239 hinge residues; other site 639283005240 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283005241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283005242 Walker A/P-loop; other site 639283005243 ATP binding site [chemical binding]; other site 639283005244 Q-loop/lid; other site 639283005245 ABC transporter signature motif; other site 639283005246 Walker B; other site 639283005247 D-loop; other site 639283005248 H-loop/switch region; other site 639283005249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283005250 dimer interface [polypeptide binding]; other site 639283005251 conserved gate region; other site 639283005252 putative PBP binding loops; other site 639283005253 ABC-ATPase subunit interface; other site 639283005254 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283005255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283005256 dimer interface [polypeptide binding]; other site 639283005257 conserved gate region; other site 639283005258 putative PBP binding loops; other site 639283005259 ABC-ATPase subunit interface; other site 639283005260 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 639283005261 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 639283005262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283005263 DNA-binding site [nucleotide binding]; DNA binding site 639283005264 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283005265 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 639283005266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283005267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283005268 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 639283005269 putative effector binding pocket; other site 639283005270 dimerization interface [polypeptide binding]; other site 639283005271 cytokinin dehydrogenase; Region: PLN02441 639283005272 FAD binding domain; Region: FAD_binding_4; pfam01565 639283005273 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 639283005274 polysaccharide export protein Wza; Provisional; Region: PRK15078 639283005275 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 639283005276 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 639283005277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283005278 Walker A/P-loop; other site 639283005279 ATP binding site [chemical binding]; other site 639283005280 Q-loop/lid; other site 639283005281 ABC transporter signature motif; other site 639283005282 Walker B; other site 639283005283 D-loop; other site 639283005284 H-loop/switch region; other site 639283005285 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 639283005286 ABC-2 type transporter; Region: ABC2_membrane; cl17235 639283005287 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 639283005288 Sulfatase; Region: Sulfatase; cl17466 639283005289 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 639283005290 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283005291 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 639283005292 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 639283005293 substrate-cofactor binding pocket; other site 639283005294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283005295 catalytic residue [active] 639283005296 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 639283005297 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 639283005298 active site 639283005299 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 639283005300 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 639283005301 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 639283005302 Enoylreductase; Region: PKS_ER; smart00829 639283005303 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 639283005304 NAD(P) binding site [chemical binding]; other site 639283005305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283005306 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 639283005307 NAD(P) binding site [chemical binding]; other site 639283005308 active site 639283005309 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 639283005310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283005311 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 639283005312 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 639283005313 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 639283005314 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 639283005315 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 639283005316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283005317 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 639283005318 NAD(P) binding site [chemical binding]; other site 639283005319 active site 639283005320 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 639283005321 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 639283005322 Substrate binding site; other site 639283005323 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 639283005324 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 639283005325 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283005326 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 639283005327 HdeA/HdeB family; Region: HdeA; cl05752 639283005328 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 639283005329 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 639283005330 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 639283005331 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 639283005332 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 639283005333 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 639283005334 thymidylate kinase; Validated; Region: tmk; PRK00698 639283005335 TMP-binding site; other site 639283005336 ATP-binding site [chemical binding]; other site 639283005337 DNA polymerase III subunit delta'; Validated; Region: PRK07471 639283005338 DNA polymerase III subunit delta'; Validated; Region: PRK08485 639283005339 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 639283005340 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 639283005341 active site 639283005342 HIGH motif; other site 639283005343 KMSKS motif; other site 639283005344 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 639283005345 tRNA binding surface [nucleotide binding]; other site 639283005346 anticodon binding site; other site 639283005347 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 639283005348 active site 639283005349 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 639283005350 putative hydrolase; Provisional; Region: PRK02113 639283005351 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 639283005352 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 639283005353 homodimer interface [polypeptide binding]; other site 639283005354 metal binding site [ion binding]; metal-binding site 639283005355 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 639283005356 homodimer interface [polypeptide binding]; other site 639283005357 active site 639283005358 putative chemical substrate binding site [chemical binding]; other site 639283005359 metal binding site [ion binding]; metal-binding site 639283005360 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 639283005361 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 639283005362 HflX GTPase family; Region: HflX; cd01878 639283005363 G1 box; other site 639283005364 GTP/Mg2+ binding site [chemical binding]; other site 639283005365 Switch I region; other site 639283005366 G2 box; other site 639283005367 G3 box; other site 639283005368 Switch II region; other site 639283005369 G4 box; other site 639283005370 G5 box; other site 639283005371 bacterial Hfq-like; Region: Hfq; cd01716 639283005372 hexamer interface [polypeptide binding]; other site 639283005373 Sm1 motif; other site 639283005374 RNA binding site [nucleotide binding]; other site 639283005375 Sm2 motif; other site 639283005376 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 639283005377 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 639283005378 homodimer interface [polypeptide binding]; other site 639283005379 substrate-cofactor binding pocket; other site 639283005380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283005381 catalytic residue [active] 639283005382 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 639283005383 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 639283005384 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 639283005385 TrkA-N domain; Region: TrkA_N; pfam02254 639283005386 TrkA-C domain; Region: TrkA_C; pfam02080 639283005387 TrkA-N domain; Region: TrkA_N; pfam02254 639283005388 TrkA-C domain; Region: TrkA_C; pfam02080 639283005389 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 639283005390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283005391 active site 639283005392 phosphorylation site [posttranslational modification] 639283005393 intermolecular recognition site; other site 639283005394 dimerization interface [polypeptide binding]; other site 639283005395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283005396 Walker A motif; other site 639283005397 ATP binding site [chemical binding]; other site 639283005398 Walker B motif; other site 639283005399 arginine finger; other site 639283005400 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 639283005401 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 639283005402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 639283005403 dimerization interface [polypeptide binding]; other site 639283005404 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283005405 putative active site [active] 639283005406 heme pocket [chemical binding]; other site 639283005407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283005408 dimer interface [polypeptide binding]; other site 639283005409 phosphorylation site [posttranslational modification] 639283005410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283005411 ATP binding site [chemical binding]; other site 639283005412 Mg2+ binding site [ion binding]; other site 639283005413 G-X-G motif; other site 639283005414 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 639283005415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283005416 active site 639283005417 phosphorylation site [posttranslational modification] 639283005418 intermolecular recognition site; other site 639283005419 dimerization interface [polypeptide binding]; other site 639283005420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283005421 Walker A motif; other site 639283005422 ATP binding site [chemical binding]; other site 639283005423 Walker B motif; other site 639283005424 arginine finger; other site 639283005425 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 639283005426 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 639283005427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 639283005428 putative active site [active] 639283005429 heme pocket [chemical binding]; other site 639283005430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283005431 dimer interface [polypeptide binding]; other site 639283005432 phosphorylation site [posttranslational modification] 639283005433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283005434 ATP binding site [chemical binding]; other site 639283005435 Mg2+ binding site [ion binding]; other site 639283005436 G-X-G motif; other site 639283005437 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 639283005438 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 639283005439 FMN binding site [chemical binding]; other site 639283005440 active site 639283005441 catalytic residues [active] 639283005442 substrate binding site [chemical binding]; other site 639283005443 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 639283005444 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 639283005445 substrate binding site; other site 639283005446 dimer interface; other site 639283005447 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 639283005448 homotrimer interaction site [polypeptide binding]; other site 639283005449 zinc binding site [ion binding]; other site 639283005450 CDP-binding sites; other site 639283005451 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 639283005452 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 639283005453 putative coenzyme Q binding site [chemical binding]; other site 639283005454 lipoyl synthase; Provisional; Region: PRK05481 639283005455 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283005456 FeS/SAM binding site; other site 639283005457 Predicted membrane protein [Function unknown]; Region: COG2261 639283005458 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 639283005459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283005460 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 639283005461 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 639283005462 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 639283005463 E3 interaction surface; other site 639283005464 lipoyl attachment site [posttranslational modification]; other site 639283005465 e3 binding domain; Region: E3_binding; pfam02817 639283005466 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 639283005467 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 639283005468 E3 interaction surface; other site 639283005469 lipoyl attachment site [posttranslational modification]; other site 639283005470 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 639283005471 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 639283005472 alpha subunit interface [polypeptide binding]; other site 639283005473 TPP binding site [chemical binding]; other site 639283005474 heterodimer interface [polypeptide binding]; other site 639283005475 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 639283005476 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 639283005477 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 639283005478 tetramer interface [polypeptide binding]; other site 639283005479 TPP-binding site [chemical binding]; other site 639283005480 heterodimer interface [polypeptide binding]; other site 639283005481 phosphorylation loop region [posttranslational modification] 639283005482 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 639283005483 Septum formation initiator; Region: DivIC; pfam04977 639283005484 Bacterial PH domain; Region: DUF304; pfam03703 639283005485 enolase; Provisional; Region: eno; PRK00077 639283005486 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 639283005487 dimer interface [polypeptide binding]; other site 639283005488 metal binding site [ion binding]; metal-binding site 639283005489 substrate binding pocket [chemical binding]; other site 639283005490 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 639283005491 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 639283005492 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 639283005493 glutaminase active site [active] 639283005494 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 639283005495 dimer interface [polypeptide binding]; other site 639283005496 active site 639283005497 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 639283005498 dimer interface [polypeptide binding]; other site 639283005499 active site 639283005500 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 639283005501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 639283005502 active site 639283005503 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 639283005504 active site 639283005505 substrate binding site [chemical binding]; other site 639283005506 CoA binding site [chemical binding]; other site 639283005507 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 639283005508 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 639283005509 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 639283005510 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 639283005511 active site 639283005512 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 639283005513 CTP synthetase; Validated; Region: pyrG; PRK05380 639283005514 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 639283005515 Catalytic site [active] 639283005516 active site 639283005517 UTP binding site [chemical binding]; other site 639283005518 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 639283005519 active site 639283005520 putative oxyanion hole; other site 639283005521 catalytic triad [active] 639283005522 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 639283005523 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 639283005524 triosephosphate isomerase; Provisional; Region: PRK14565 639283005525 substrate binding site [chemical binding]; other site 639283005526 dimer interface [polypeptide binding]; other site 639283005527 catalytic triad [active] 639283005528 SurA N-terminal domain; Region: SurA_N_3; cl07813 639283005529 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 639283005530 anthranilate synthase component I; Provisional; Region: PRK13573 639283005531 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 639283005532 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 639283005533 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 639283005534 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 639283005535 glutamine binding [chemical binding]; other site 639283005536 catalytic triad [active] 639283005537 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 639283005538 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 639283005539 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 639283005540 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 639283005541 active site 639283005542 ribulose/triose binding site [chemical binding]; other site 639283005543 phosphate binding site [ion binding]; other site 639283005544 substrate (anthranilate) binding pocket [chemical binding]; other site 639283005545 product (indole) binding pocket [chemical binding]; other site 639283005546 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 639283005547 trimer interface [polypeptide binding]; other site 639283005548 dimer interface [polypeptide binding]; other site 639283005549 putative active site [active] 639283005550 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 639283005551 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 639283005552 dimer interface [polypeptide binding]; other site 639283005553 putative functional site; other site 639283005554 putative MPT binding site; other site 639283005555 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 639283005556 SnoaL-like domain; Region: SnoaL_3; pfam13474 639283005557 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283005558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283005559 DNA-binding site [nucleotide binding]; DNA binding site 639283005560 FCD domain; Region: FCD; pfam07729 639283005561 LexA repressor; Validated; Region: PRK00215 639283005562 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 639283005563 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 639283005564 Catalytic site [active] 639283005565 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 639283005566 Competence protein; Region: Competence; pfam03772 639283005567 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 639283005568 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 639283005569 active site 639283005570 HIGH motif; other site 639283005571 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 639283005572 active site 639283005573 KMSKS motif; other site 639283005574 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 639283005575 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 639283005576 dimer interface [polypeptide binding]; other site 639283005577 active site 639283005578 citrylCoA binding site [chemical binding]; other site 639283005579 NADH binding [chemical binding]; other site 639283005580 cationic pore residues; other site 639283005581 oxalacetate/citrate binding site [chemical binding]; other site 639283005582 coenzyme A binding site [chemical binding]; other site 639283005583 catalytic triad [active] 639283005584 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 639283005585 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 639283005586 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 639283005587 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 639283005588 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 639283005589 active site 639283005590 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 639283005591 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 639283005592 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 639283005593 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 639283005594 trimer interface [polypeptide binding]; other site 639283005595 active site 639283005596 UDP-GlcNAc binding site [chemical binding]; other site 639283005597 lipid binding site [chemical binding]; lipid-binding site 639283005598 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 639283005599 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 639283005600 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 639283005601 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 639283005602 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 639283005603 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 639283005604 Surface antigen; Region: Bac_surface_Ag; pfam01103 639283005605 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 639283005606 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 639283005607 active site 639283005608 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 639283005609 protein binding site [polypeptide binding]; other site 639283005610 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 639283005611 putative substrate binding region [chemical binding]; other site 639283005612 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 639283005613 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 639283005614 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 639283005615 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 639283005616 catalytic residue [active] 639283005617 putative FPP diphosphate binding site; other site 639283005618 putative FPP binding hydrophobic cleft; other site 639283005619 dimer interface [polypeptide binding]; other site 639283005620 putative IPP diphosphate binding site; other site 639283005621 ribosome recycling factor; Reviewed; Region: frr; PRK00083 639283005622 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 639283005623 hinge region; other site 639283005624 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 639283005625 putative nucleotide binding site [chemical binding]; other site 639283005626 uridine monophosphate binding site [chemical binding]; other site 639283005627 homohexameric interface [polypeptide binding]; other site 639283005628 elongation factor Ts; Provisional; Region: tsf; PRK09377 639283005629 UBA/TS-N domain; Region: UBA; pfam00627 639283005630 Elongation factor TS; Region: EF_TS; pfam00889 639283005631 Elongation factor TS; Region: EF_TS; pfam00889 639283005632 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 639283005633 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 639283005634 rRNA interaction site [nucleotide binding]; other site 639283005635 S8 interaction site; other site 639283005636 putative laminin-1 binding site; other site 639283005637 Uncharacterized conserved protein [Function unknown]; Region: COG3743 639283005638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 639283005639 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 639283005640 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 639283005641 putative active site [active] 639283005642 putative PHP Thumb interface [polypeptide binding]; other site 639283005643 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 639283005644 generic binding surface II; other site 639283005645 generic binding surface I; other site 639283005646 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 639283005647 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 639283005648 Walker A/P-loop; other site 639283005649 ATP binding site [chemical binding]; other site 639283005650 Q-loop/lid; other site 639283005651 ABC transporter signature motif; other site 639283005652 Walker B; other site 639283005653 D-loop; other site 639283005654 H-loop/switch region; other site 639283005655 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 639283005656 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 639283005657 FtsX-like permease family; Region: FtsX; pfam02687 639283005658 prolyl-tRNA synthetase; Provisional; Region: PRK12325 639283005659 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 639283005660 dimer interface [polypeptide binding]; other site 639283005661 motif 1; other site 639283005662 active site 639283005663 motif 2; other site 639283005664 motif 3; other site 639283005665 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 639283005666 anticodon binding site; other site 639283005667 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 639283005668 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283005669 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 639283005670 dimer interface [polypeptide binding]; other site 639283005671 substrate binding site [chemical binding]; other site 639283005672 metal binding site [ion binding]; metal-binding site 639283005673 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 639283005674 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 639283005675 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 639283005676 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 639283005677 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 639283005678 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 639283005679 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 639283005680 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 639283005681 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 639283005682 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 639283005683 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 639283005684 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 639283005685 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 639283005686 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 639283005687 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 639283005688 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 639283005689 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 639283005690 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 639283005691 4Fe-4S binding domain; Region: Fer4; pfam00037 639283005692 4Fe-4S binding domain; Region: Fer4; pfam00037 639283005693 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 639283005694 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 639283005695 NADH dehydrogenase subunit G; Validated; Region: PRK09130 639283005696 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283005697 catalytic loop [active] 639283005698 iron binding site [ion binding]; other site 639283005699 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 639283005700 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 639283005701 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 639283005702 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 639283005703 SLBB domain; Region: SLBB; pfam10531 639283005704 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 639283005705 NADH dehydrogenase subunit E; Validated; Region: PRK07539 639283005706 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 639283005707 putative dimer interface [polypeptide binding]; other site 639283005708 [2Fe-2S] cluster binding site [ion binding]; other site 639283005709 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 639283005710 NADH dehydrogenase subunit D; Validated; Region: PRK06075 639283005711 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 639283005712 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 639283005713 NADH dehydrogenase subunit B; Validated; Region: PRK06411 639283005714 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 639283005715 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 639283005716 Methyltransferase domain; Region: Methyltransf_23; pfam13489 639283005717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283005718 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 639283005719 Domain of unknown function DUF20; Region: UPF0118; pfam01594 639283005720 KpsF/GutQ family protein; Region: kpsF; TIGR00393 639283005721 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 639283005722 putative active site [active] 639283005723 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 639283005724 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 639283005725 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 639283005726 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 639283005727 substrate binding pocket [chemical binding]; other site 639283005728 substrate-Mg2+ binding site; other site 639283005729 aspartate-rich region 2; other site 639283005730 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 639283005731 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 639283005732 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 639283005733 Protein export membrane protein; Region: SecD_SecF; pfam02355 639283005734 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 639283005735 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 639283005736 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 639283005737 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 639283005738 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 639283005739 Protein of unknown function (DUF815); Region: DUF815; pfam05673 639283005740 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 639283005741 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 639283005742 Peptidase family M23; Region: Peptidase_M23; pfam01551 639283005743 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 639283005744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283005745 S-adenosylmethionine binding site [chemical binding]; other site 639283005746 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 639283005747 seryl-tRNA synthetase; Region: serS; TIGR00414 639283005748 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 639283005749 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 639283005750 dimer interface [polypeptide binding]; other site 639283005751 active site 639283005752 motif 1; other site 639283005753 motif 2; other site 639283005754 motif 3; other site 639283005755 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 639283005756 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 639283005757 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 639283005758 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 639283005759 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283005760 Walker A/P-loop; other site 639283005761 ATP binding site [chemical binding]; other site 639283005762 Q-loop/lid; other site 639283005763 ABC transporter signature motif; other site 639283005764 Walker B; other site 639283005765 D-loop; other site 639283005766 H-loop/switch region; other site 639283005767 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 639283005768 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 639283005769 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 639283005770 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 639283005771 Sporulation related domain; Region: SPOR; pfam05036 639283005772 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 639283005773 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 639283005774 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 639283005775 active site 639283005776 HIGH motif; other site 639283005777 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 639283005778 KMSK motif region; other site 639283005779 tRNA binding surface [nucleotide binding]; other site 639283005780 DALR anticodon binding domain; Region: DALR_1; smart00836 639283005781 anticodon binding site; other site 639283005782 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 639283005783 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 639283005784 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 639283005785 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 639283005786 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 639283005787 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 639283005788 putative catalytic site [active] 639283005789 putative phosphate binding site [ion binding]; other site 639283005790 active site 639283005791 metal binding site A [ion binding]; metal-binding site 639283005792 DNA binding site [nucleotide binding] 639283005793 putative AP binding site [nucleotide binding]; other site 639283005794 putative metal binding site B [ion binding]; other site 639283005795 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 639283005796 Sel1-like repeats; Region: SEL1; smart00671 639283005797 Sel1-like repeats; Region: SEL1; smart00671 639283005798 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 639283005799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 639283005800 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 639283005801 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 639283005802 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 639283005803 Walker A/P-loop; other site 639283005804 ATP binding site [chemical binding]; other site 639283005805 Q-loop/lid; other site 639283005806 ABC transporter signature motif; other site 639283005807 Walker B; other site 639283005808 D-loop; other site 639283005809 H-loop/switch region; other site 639283005810 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283005811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283005812 DNA-binding site [nucleotide binding]; DNA binding site 639283005813 FCD domain; Region: FCD; pfam07729 639283005814 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 639283005815 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 639283005816 active site pocket [active] 639283005817 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 639283005818 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 639283005819 NADP binding site [chemical binding]; other site 639283005820 homodimer interface [polypeptide binding]; other site 639283005821 active site 639283005822 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 639283005823 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 639283005824 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 639283005825 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 639283005826 DctM-like transporters; Region: DctM; pfam06808 639283005827 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 639283005828 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 639283005829 putative NAD(P) binding site [chemical binding]; other site 639283005830 catalytic Zn binding site [ion binding]; other site 639283005831 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 639283005832 ATP-binding site [chemical binding]; other site 639283005833 Gluconate-6-phosphate binding site [chemical binding]; other site 639283005834 Shikimate kinase; Region: SKI; pfam01202 639283005835 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 639283005836 Transcriptional regulators [Transcription]; Region: PurR; COG1609 639283005837 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 639283005838 DNA binding site [nucleotide binding] 639283005839 domain linker motif; other site 639283005840 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 639283005841 putative ligand binding site [chemical binding]; other site 639283005842 putative dimerization interface [polypeptide binding]; other site 639283005843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283005844 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 639283005845 NAD(P) binding site [chemical binding]; other site 639283005846 active site 639283005847 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 639283005848 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 639283005849 Walker A/P-loop; other site 639283005850 ATP binding site [chemical binding]; other site 639283005851 Q-loop/lid; other site 639283005852 ABC transporter signature motif; other site 639283005853 Walker B; other site 639283005854 D-loop; other site 639283005855 H-loop/switch region; other site 639283005856 TOBE domain; Region: TOBE_2; pfam08402 639283005857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283005858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283005859 dimer interface [polypeptide binding]; other site 639283005860 conserved gate region; other site 639283005861 putative PBP binding loops; other site 639283005862 ABC-ATPase subunit interface; other site 639283005863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283005864 dimer interface [polypeptide binding]; other site 639283005865 conserved gate region; other site 639283005866 putative PBP binding loops; other site 639283005867 ABC-ATPase subunit interface; other site 639283005868 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283005869 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 639283005870 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 639283005871 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 639283005872 phosphate binding site [ion binding]; other site 639283005873 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 639283005874 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283005875 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 639283005876 dihydroxy-acid dehydratase; Validated; Region: PRK06131 639283005877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283005878 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 639283005879 DNA-binding site [nucleotide binding]; DNA binding site 639283005880 FCD domain; Region: FCD; pfam07729 639283005881 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 639283005882 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 639283005883 inhibitor site; inhibition site 639283005884 active site 639283005885 dimer interface [polypeptide binding]; other site 639283005886 catalytic residue [active] 639283005887 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 639283005888 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 639283005889 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 639283005890 HIGH motif; other site 639283005891 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 639283005892 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 639283005893 active site 639283005894 KMSKS motif; other site 639283005895 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 639283005896 tRNA binding surface [nucleotide binding]; other site 639283005897 anticodon binding site; other site 639283005898 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 639283005899 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 639283005900 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 639283005901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283005902 S-adenosylmethionine binding site [chemical binding]; other site 639283005903 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 639283005904 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 639283005905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283005906 Walker A/P-loop; other site 639283005907 ATP binding site [chemical binding]; other site 639283005908 Q-loop/lid; other site 639283005909 ABC transporter signature motif; other site 639283005910 Walker B; other site 639283005911 D-loop; other site 639283005912 H-loop/switch region; other site 639283005913 integrase; Provisional; Region: PRK09692 639283005914 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 639283005915 active site 639283005916 Int/Topo IB signature motif; other site 639283005917 Fic family protein [Function unknown]; Region: COG3177 639283005918 Fic/DOC family; Region: Fic; pfam02661 639283005919 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 639283005920 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 639283005921 MobA/MobL family; Region: MobA_MobL; pfam03389 639283005922 AAA domain; Region: AAA_30; pfam13604 639283005923 Family description; Region: UvrD_C_2; pfam13538 639283005924 Conjugal transfer protein TraD; Region: TraD; pfam06412 639283005925 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 639283005926 active site 639283005927 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 639283005928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 639283005929 ATP binding site [chemical binding]; other site 639283005930 putative Mg++ binding site [ion binding]; other site 639283005931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 639283005932 nucleotide binding region [chemical binding]; other site 639283005933 ATP-binding site [chemical binding]; other site 639283005934 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 639283005935 AAA ATPase domain; Region: AAA_16; pfam13191 639283005936 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283005937 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 639283005938 tellurite resistance protein terB; Region: terB; cd07176 639283005939 putative metal binding site [ion binding]; other site 639283005940 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 639283005941 non-specific DNA binding site [nucleotide binding]; other site 639283005942 salt bridge; other site 639283005943 sequence-specific DNA binding site [nucleotide binding]; other site 639283005944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283005945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283005946 non-specific DNA binding site [nucleotide binding]; other site 639283005947 salt bridge; other site 639283005948 sequence-specific DNA binding site [nucleotide binding]; other site 639283005949 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 639283005950 Phage-related minor tail protein [Function unknown]; Region: COG5281 639283005951 tape measure domain; Region: tape_meas_nterm; TIGR02675 639283005952 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 639283005953 Phage capsid family; Region: Phage_capsid; pfam05065 639283005954 AAA domain; Region: AAA_25; pfam13481 639283005955 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 639283005956 Walker A motif; other site 639283005957 ATP binding site [chemical binding]; other site 639283005958 Walker B motif; other site 639283005959 Toprim domain; Region: Toprim_3; pfam13362 639283005960 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 639283005961 integrase; Provisional; Region: PRK09692 639283005962 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 639283005963 active site 639283005964 Int/Topo IB signature motif; other site 639283005965 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 639283005966 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 639283005967 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 639283005968 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 639283005969 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 639283005970 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 639283005971 active site 639283005972 FMN binding site [chemical binding]; other site 639283005973 substrate binding site [chemical binding]; other site 639283005974 putative catalytic residue [active] 639283005975 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 639283005976 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 639283005977 active site 639283005978 catalytic residues [active] 639283005979 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 639283005980 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283005981 catalytic loop [active] 639283005982 iron binding site [ion binding]; other site 639283005983 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 639283005984 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283005985 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 639283005986 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 639283005987 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283005988 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283005989 Cytochrome c; Region: Cytochrom_C; cl11414 639283005990 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 639283005991 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 639283005992 Cytochrome c; Region: Cytochrom_C; cl11414 639283005993 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 639283005994 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 639283005995 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 639283005996 Cytochrome c [Energy production and conversion]; Region: COG3258 639283005997 osmolarity response regulator; Provisional; Region: ompR; PRK09468 639283005998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283005999 active site 639283006000 phosphorylation site [posttranslational modification] 639283006001 intermolecular recognition site; other site 639283006002 dimerization interface [polypeptide binding]; other site 639283006003 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283006004 DNA binding site [nucleotide binding] 639283006005 CheW-like domain; Region: CheW; pfam01584 639283006006 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 639283006007 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 639283006008 CheW-like domain; Region: CheW; pfam01584 639283006009 Cache domain; Region: Cache_1; pfam02743 639283006010 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 639283006011 dimerization interface [polypeptide binding]; other site 639283006012 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 639283006013 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 639283006014 dimer interface [polypeptide binding]; other site 639283006015 putative CheW interface [polypeptide binding]; other site 639283006016 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 639283006017 putative binding surface; other site 639283006018 active site 639283006019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283006020 ATP binding site [chemical binding]; other site 639283006021 Mg2+ binding site [ion binding]; other site 639283006022 G-X-G motif; other site 639283006023 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 639283006024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006025 active site 639283006026 phosphorylation site [posttranslational modification] 639283006027 intermolecular recognition site; other site 639283006028 dimerization interface [polypeptide binding]; other site 639283006029 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 639283006030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006031 active site 639283006032 phosphorylation site [posttranslational modification] 639283006033 intermolecular recognition site; other site 639283006034 dimerization interface [polypeptide binding]; other site 639283006035 CheB methylesterase; Region: CheB_methylest; pfam01339 639283006036 Response regulator receiver domain; Region: Response_reg; pfam00072 639283006037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006038 active site 639283006039 phosphorylation site [posttranslational modification] 639283006040 intermolecular recognition site; other site 639283006041 dimerization interface [polypeptide binding]; other site 639283006042 GAF domain; Region: GAF_2; pfam13185 639283006043 GAF domain; Region: GAF_3; pfam13492 639283006044 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 639283006045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283006046 dimer interface [polypeptide binding]; other site 639283006047 phosphorylation site [posttranslational modification] 639283006048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283006049 ATP binding site [chemical binding]; other site 639283006050 Mg2+ binding site [ion binding]; other site 639283006051 G-X-G motif; other site 639283006052 Response regulator receiver domain; Region: Response_reg; pfam00072 639283006053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006054 active site 639283006055 phosphorylation site [posttranslational modification] 639283006056 intermolecular recognition site; other site 639283006057 dimerization interface [polypeptide binding]; other site 639283006058 Response regulator receiver domain; Region: Response_reg; pfam00072 639283006059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006060 active site 639283006061 phosphorylation site [posttranslational modification] 639283006062 intermolecular recognition site; other site 639283006063 dimerization interface [polypeptide binding]; other site 639283006064 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283006065 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 639283006066 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 639283006067 anti sigma factor interaction site; other site 639283006068 regulatory phosphorylation site [posttranslational modification]; other site 639283006069 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 639283006070 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 639283006071 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 639283006072 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 639283006073 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 639283006074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006075 active site 639283006076 phosphorylation site [posttranslational modification] 639283006077 intermolecular recognition site; other site 639283006078 dimerization interface [polypeptide binding]; other site 639283006079 PAS fold; Region: PAS_7; pfam12860 639283006080 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 639283006081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283006082 putative active site [active] 639283006083 heme pocket [chemical binding]; other site 639283006084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283006085 dimer interface [polypeptide binding]; other site 639283006086 phosphorylation site [posttranslational modification] 639283006087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283006088 ATP binding site [chemical binding]; other site 639283006089 Mg2+ binding site [ion binding]; other site 639283006090 G-X-G motif; other site 639283006091 Response regulator receiver domain; Region: Response_reg; pfam00072 639283006092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006093 active site 639283006094 phosphorylation site [posttranslational modification] 639283006095 intermolecular recognition site; other site 639283006096 dimerization interface [polypeptide binding]; other site 639283006097 Response regulator receiver domain; Region: Response_reg; pfam00072 639283006098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006099 active site 639283006100 phosphorylation site [posttranslational modification] 639283006101 intermolecular recognition site; other site 639283006102 Response regulator receiver domain; Region: Response_reg; pfam00072 639283006103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006104 active site 639283006105 phosphorylation site [posttranslational modification] 639283006106 intermolecular recognition site; other site 639283006107 dimerization interface [polypeptide binding]; other site 639283006108 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 639283006109 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 639283006110 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 639283006111 dimer interface [polypeptide binding]; other site 639283006112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283006113 catalytic residue [active] 639283006114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 639283006115 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 639283006116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 639283006117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283006118 DNA binding residues [nucleotide binding] 639283006119 dimerization interface [polypeptide binding]; other site 639283006120 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 639283006121 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 639283006122 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283006123 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 639283006124 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 639283006125 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 639283006126 Walker A/P-loop; other site 639283006127 ATP binding site [chemical binding]; other site 639283006128 Q-loop/lid; other site 639283006129 ABC transporter signature motif; other site 639283006130 Walker B; other site 639283006131 D-loop; other site 639283006132 H-loop/switch region; other site 639283006133 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 639283006134 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 639283006135 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 639283006136 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 639283006137 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 639283006138 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 639283006139 active site 639283006140 dimer interface [polypeptide binding]; other site 639283006141 motif 1; other site 639283006142 motif 2; other site 639283006143 motif 3; other site 639283006144 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 639283006145 anticodon binding site; other site 639283006146 hypothetical protein; Validated; Region: PRK00041 639283006147 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 639283006148 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 639283006149 trimerization site [polypeptide binding]; other site 639283006150 active site 639283006151 GTP cyclohydrolase I; Provisional; Region: PLN03044 639283006152 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 639283006153 active site 639283006154 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 639283006155 FOG: CBS domain [General function prediction only]; Region: COG0517 639283006156 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 639283006157 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 639283006158 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 639283006159 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 639283006160 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 639283006161 trimer interface [polypeptide binding]; other site 639283006162 putative metal binding site [ion binding]; other site 639283006163 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 639283006164 serine acetyltransferase; Provisional; Region: cysE; PRK11132 639283006165 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 639283006166 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 639283006167 trimer interface [polypeptide binding]; other site 639283006168 active site 639283006169 substrate binding site [chemical binding]; other site 639283006170 CoA binding site [chemical binding]; other site 639283006171 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283006172 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 639283006173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 639283006174 salicylate hydroxylase; Provisional; Region: PRK08163 639283006175 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 639283006176 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 639283006177 EamA-like transporter family; Region: EamA; pfam00892 639283006178 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 639283006179 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 639283006180 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 639283006181 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 639283006182 Proline dehydrogenase; Region: Pro_dh; pfam01619 639283006183 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 639283006184 Glutamate binding site [chemical binding]; other site 639283006185 NAD binding site [chemical binding]; other site 639283006186 catalytic residues [active] 639283006187 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 639283006188 NAD(P) binding site [chemical binding]; other site 639283006189 MarR family; Region: MarR; pfam01047 639283006190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283006191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283006192 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 639283006193 putative effector binding pocket; other site 639283006194 putative dimerization interface [polypeptide binding]; other site 639283006195 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 639283006196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283006197 NAD(P) binding site [chemical binding]; other site 639283006198 active site 639283006199 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 639283006200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283006201 DNA-binding site [nucleotide binding]; DNA binding site 639283006202 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 639283006203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283006204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283006205 homodimer interface [polypeptide binding]; other site 639283006206 catalytic residue [active] 639283006207 Predicted membrane protein [Function unknown]; Region: COG3918 639283006208 mercuric reductase; Validated; Region: PRK06370 639283006209 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 639283006210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283006211 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 639283006212 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283006213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283006214 dimer interface [polypeptide binding]; other site 639283006215 conserved gate region; other site 639283006216 putative PBP binding loops; other site 639283006217 ABC-ATPase subunit interface; other site 639283006218 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283006219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283006220 dimer interface [polypeptide binding]; other site 639283006221 conserved gate region; other site 639283006222 putative PBP binding loops; other site 639283006223 ABC-ATPase subunit interface; other site 639283006224 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283006225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283006226 Walker A/P-loop; other site 639283006227 ATP binding site [chemical binding]; other site 639283006228 Q-loop/lid; other site 639283006229 ABC transporter signature motif; other site 639283006230 Walker B; other site 639283006231 D-loop; other site 639283006232 H-loop/switch region; other site 639283006233 TOBE domain; Region: TOBE_2; pfam08402 639283006234 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 639283006235 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283006236 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 639283006237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283006238 Walker A motif; other site 639283006239 ATP binding site [chemical binding]; other site 639283006240 Walker B motif; other site 639283006241 arginine finger; other site 639283006242 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 639283006243 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 639283006244 FAD binding domain; Region: FAD_binding_4; pfam01565 639283006245 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 639283006246 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 639283006247 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 639283006248 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 639283006249 choline dehydrogenase; Validated; Region: PRK02106 639283006250 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 639283006251 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 639283006252 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 639283006253 NAD(P) binding site [chemical binding]; other site 639283006254 catalytic residues [active] 639283006255 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 639283006256 short chain dehydrogenase; Provisional; Region: PRK06500 639283006257 classical (c) SDRs; Region: SDR_c; cd05233 639283006258 NAD(P) binding site [chemical binding]; other site 639283006259 active site 639283006260 Predicted transcriptional regulators [Transcription]; Region: COG1733 639283006261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283006262 putative DNA binding site [nucleotide binding]; other site 639283006263 putative Zn2+ binding site [ion binding]; other site 639283006264 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 639283006265 homotrimer interaction site [polypeptide binding]; other site 639283006266 putative active site [active] 639283006267 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 639283006268 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 639283006269 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 639283006270 active site 639283006271 Int/Topo IB signature motif; other site 639283006272 DNA binding site [nucleotide binding] 639283006273 Phage-related protein [Function unknown]; Region: COG4695 639283006274 Phage portal protein; Region: Phage_portal; pfam04860 639283006275 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 639283006276 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 639283006277 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 639283006278 Phage capsid family; Region: Phage_capsid; pfam05065 639283006279 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 639283006280 active site 639283006281 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 639283006282 oligomerization interface [polypeptide binding]; other site 639283006283 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 639283006284 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 639283006285 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 639283006286 Phage terminase, small subunit; Region: Terminase_4; pfam05119 639283006287 Phage Terminase; Region: Terminase_1; pfam03354 639283006288 FRG domain; Region: FRG; pfam08867 639283006289 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 639283006290 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 639283006291 Potassium binding sites [ion binding]; other site 639283006292 Cesium cation binding sites [ion binding]; other site 639283006293 Predicted membrane protein [Function unknown]; Region: COG2259 639283006294 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283006295 active site 639283006296 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 639283006297 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 639283006298 putative MPT binding site; other site 639283006299 Uncharacterized conserved protein [Function unknown]; Region: COG2308 639283006300 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 639283006301 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 639283006302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 639283006303 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 639283006304 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 639283006305 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 639283006306 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 639283006307 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 639283006308 active site 639283006309 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 639283006310 classical (c) SDRs; Region: SDR_c; cd05233 639283006311 NAD(P) binding site [chemical binding]; other site 639283006312 active site 639283006313 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 639283006314 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 639283006315 Usg-like family; Region: Usg; pfam06233 639283006316 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 639283006317 oligomerisation interface [polypeptide binding]; other site 639283006318 mobile loop; other site 639283006319 roof hairpin; other site 639283006320 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 639283006321 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 639283006322 ring oligomerisation interface [polypeptide binding]; other site 639283006323 ATP/Mg binding site [chemical binding]; other site 639283006324 stacking interactions; other site 639283006325 hinge regions; other site 639283006326 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 639283006327 GIY-YIG motif/motif A; other site 639283006328 putative active site [active] 639283006329 putative metal binding site [ion binding]; other site 639283006330 Protein of unknown function (DUF330); Region: DUF330; cl01135 639283006331 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 639283006332 mce related protein; Region: MCE; pfam02470 639283006333 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 639283006334 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 639283006335 Walker A/P-loop; other site 639283006336 ATP binding site [chemical binding]; other site 639283006337 Q-loop/lid; other site 639283006338 ABC transporter signature motif; other site 639283006339 Walker B; other site 639283006340 D-loop; other site 639283006341 H-loop/switch region; other site 639283006342 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 639283006343 Permease; Region: Permease; pfam02405 639283006344 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 639283006345 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 639283006346 active site 639283006347 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 639283006348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283006349 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 639283006350 dimer interface [polypeptide binding]; other site 639283006351 substrate binding site [chemical binding]; other site 639283006352 ATP binding site [chemical binding]; other site 639283006353 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 639283006354 AsnC family; Region: AsnC_trans_reg; pfam01037 639283006355 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 639283006356 Cytochrome C' Region: Cytochrom_C_2; pfam01322 639283006357 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 639283006358 Ligand Binding Site [chemical binding]; other site 639283006359 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 639283006360 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 639283006361 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 639283006362 putative active site [active] 639283006363 putative metal binding site [ion binding]; other site 639283006364 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283006365 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 639283006366 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 639283006367 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 639283006368 tetramer interface [polypeptide binding]; other site 639283006369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283006370 catalytic residue [active] 639283006371 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283006372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283006373 non-specific DNA binding site [nucleotide binding]; other site 639283006374 salt bridge; other site 639283006375 sequence-specific DNA binding site [nucleotide binding]; other site 639283006376 Cupin domain; Region: Cupin_2; pfam07883 639283006377 Uncharacterized conserved protein [Function unknown]; Region: COG3391 639283006378 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 639283006379 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 639283006380 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 639283006381 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 639283006382 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 639283006383 DctM-like transporters; Region: DctM; pfam06808 639283006384 HerA helicase [Replication, recombination, and repair]; Region: COG0433 639283006385 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 639283006386 Walker A motif; other site 639283006387 ATP binding site [chemical binding]; other site 639283006388 Walker B motif; other site 639283006389 Protein of unknown function, DUF488; Region: DUF488; pfam04343 639283006390 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 639283006391 metal-binding site 639283006392 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 639283006393 XdhC Rossmann domain; Region: XdhC_C; pfam13478 639283006394 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 639283006395 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 639283006396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 639283006397 Predicted flavoproteins [General function prediction only]; Region: COG2081 639283006398 hydroxyglutarate oxidase; Provisional; Region: PRK11728 639283006399 Flavin Reductases; Region: FlaRed; cl00801 639283006400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283006401 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283006402 TM-ABC transporter signature motif; other site 639283006403 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 639283006404 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 639283006405 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283006406 TM-ABC transporter signature motif; other site 639283006407 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283006408 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283006409 Walker A/P-loop; other site 639283006410 ATP binding site [chemical binding]; other site 639283006411 Q-loop/lid; other site 639283006412 ABC transporter signature motif; other site 639283006413 Walker B; other site 639283006414 D-loop; other site 639283006415 H-loop/switch region; other site 639283006416 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283006417 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283006418 Walker A/P-loop; other site 639283006419 ATP binding site [chemical binding]; other site 639283006420 Q-loop/lid; other site 639283006421 ABC transporter signature motif; other site 639283006422 Walker B; other site 639283006423 D-loop; other site 639283006424 H-loop/switch region; other site 639283006425 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 639283006426 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 639283006427 dimerization interface [polypeptide binding]; other site 639283006428 ligand binding site [chemical binding]; other site 639283006429 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 639283006430 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 639283006431 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 639283006432 putative active site pocket [active] 639283006433 cleavage site 639283006434 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 639283006435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283006436 Walker A/P-loop; other site 639283006437 ATP binding site [chemical binding]; other site 639283006438 Q-loop/lid; other site 639283006439 ABC transporter signature motif; other site 639283006440 Walker B; other site 639283006441 D-loop; other site 639283006442 H-loop/switch region; other site 639283006443 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283006444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283006445 dimer interface [polypeptide binding]; other site 639283006446 conserved gate region; other site 639283006447 putative PBP binding loops; other site 639283006448 ABC-ATPase subunit interface; other site 639283006449 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 639283006450 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 639283006451 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 639283006452 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 639283006453 substrate binding site [chemical binding]; other site 639283006454 hexamer interface [polypeptide binding]; other site 639283006455 metal binding site [ion binding]; metal-binding site 639283006456 adenylosuccinate lyase; Provisional; Region: PRK07492 639283006457 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 639283006458 tetramer interface [polypeptide binding]; other site 639283006459 active site 639283006460 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283006461 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283006462 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283006463 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283006464 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283006465 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283006466 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283006467 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 639283006468 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 639283006469 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 639283006470 ATP binding site [chemical binding]; other site 639283006471 active site 639283006472 substrate binding site [chemical binding]; other site 639283006473 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 639283006474 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 639283006475 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 639283006476 putative active site [active] 639283006477 catalytic triad [active] 639283006478 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 639283006479 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 639283006480 dimerization interface [polypeptide binding]; other site 639283006481 ATP binding site [chemical binding]; other site 639283006482 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 639283006483 dimerization interface [polypeptide binding]; other site 639283006484 ATP binding site [chemical binding]; other site 639283006485 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 639283006486 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 639283006487 putative GSH binding site [chemical binding]; other site 639283006488 catalytic residues [active] 639283006489 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 639283006490 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 639283006491 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 639283006492 RNA binding surface [nucleotide binding]; other site 639283006493 Transglycosylase SLT domain; Region: SLT_2; pfam13406 639283006494 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 639283006495 N-acetyl-D-glucosamine binding site [chemical binding]; other site 639283006496 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283006497 glutamate racemase; Provisional; Region: PRK00865 639283006498 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 639283006499 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 639283006500 isocitrate dehydrogenase; Validated; Region: PRK08299 639283006501 Ion transport protein; Region: Ion_trans; pfam00520 639283006502 Ion channel; Region: Ion_trans_2; pfam07885 639283006503 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 639283006504 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 639283006505 ligand binding site [chemical binding]; other site 639283006506 flexible hinge region; other site 639283006507 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 639283006508 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 639283006509 motif 1; other site 639283006510 active site 639283006511 motif 2; other site 639283006512 motif 3; other site 639283006513 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 639283006514 recombinase A; Provisional; Region: recA; PRK09354 639283006515 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 639283006516 hexamer interface [polypeptide binding]; other site 639283006517 Walker A motif; other site 639283006518 ATP binding site [chemical binding]; other site 639283006519 Walker B motif; other site 639283006520 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 639283006521 dimer interface [polypeptide binding]; other site 639283006522 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283006523 BNR repeat-like domain; Region: BNR_2; pfam13088 639283006524 Ubiquitin-like proteins; Region: UBQ; cl00155 639283006525 charged pocket; other site 639283006526 hydrophobic patch; other site 639283006527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 639283006528 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 639283006529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283006530 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 639283006531 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283006532 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 639283006533 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 639283006534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283006535 dimer interface [polypeptide binding]; other site 639283006536 conserved gate region; other site 639283006537 putative PBP binding loops; other site 639283006538 ABC-ATPase subunit interface; other site 639283006539 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283006540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283006541 dimer interface [polypeptide binding]; other site 639283006542 conserved gate region; other site 639283006543 putative PBP binding loops; other site 639283006544 ABC-ATPase subunit interface; other site 639283006545 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283006546 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 639283006547 Walker A/P-loop; other site 639283006548 ATP binding site [chemical binding]; other site 639283006549 Q-loop/lid; other site 639283006550 ABC transporter signature motif; other site 639283006551 Walker B; other site 639283006552 D-loop; other site 639283006553 H-loop/switch region; other site 639283006554 TOBE domain; Region: TOBE_2; pfam08402 639283006555 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 639283006556 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 639283006557 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 639283006558 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 639283006559 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 639283006560 Moco binding site; other site 639283006561 metal coordination site [ion binding]; other site 639283006562 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 639283006563 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 639283006564 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 639283006565 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 639283006566 RNA polymerase sigma factor; Provisional; Region: PRK12536 639283006567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283006568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 639283006569 DNA binding residues [nucleotide binding] 639283006570 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 639283006571 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 639283006572 homotrimer interaction site [polypeptide binding]; other site 639283006573 putative active site [active] 639283006574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283006575 TPR repeat; Region: TPR_11; pfam13414 639283006576 binding surface 639283006577 TPR motif; other site 639283006578 TPR repeat; Region: TPR_11; pfam13414 639283006579 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 639283006580 active site 639283006581 cosubstrate binding site; other site 639283006582 substrate binding site [chemical binding]; other site 639283006583 catalytic site [active] 639283006584 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 639283006585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 639283006586 dimerization interface [polypeptide binding]; other site 639283006587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283006588 Major Facilitator Superfamily; Region: MFS_1; pfam07690 639283006589 putative substrate translocation pore; other site 639283006590 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 639283006591 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 639283006592 VacJ like lipoprotein; Region: VacJ; cl01073 639283006593 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 639283006594 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 639283006595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283006596 Walker A/P-loop; other site 639283006597 ATP binding site [chemical binding]; other site 639283006598 Q-loop/lid; other site 639283006599 ABC transporter signature motif; other site 639283006600 Walker B; other site 639283006601 D-loop; other site 639283006602 H-loop/switch region; other site 639283006603 Permease; Region: Permease; cl00510 639283006604 ParA-like protein; Provisional; Region: PHA02518 639283006605 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 639283006606 P-loop; other site 639283006607 Magnesium ion binding site [ion binding]; other site 639283006608 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 639283006609 Protein export membrane protein; Region: SecD_SecF; cl14618 639283006610 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 639283006611 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 639283006612 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 639283006613 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 639283006614 intersubunit interface [polypeptide binding]; other site 639283006615 propionate/acetate kinase; Provisional; Region: PRK12379 639283006616 Acetokinase family; Region: Acetate_kinase; cl17229 639283006617 Uncharacterized conserved protein [Function unknown]; Region: COG5649 639283006618 Uncharacterized conserved protein [Function unknown]; Region: COG5649 639283006619 ATP12 chaperone protein; Region: ATP12; cl02228 639283006620 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 639283006621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283006622 motif II; other site 639283006623 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 639283006624 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 639283006625 intersubunit interface [polypeptide binding]; other site 639283006626 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 639283006627 IHF dimer interface [polypeptide binding]; other site 639283006628 IHF - DNA interface [nucleotide binding]; other site 639283006629 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 639283006630 Found in ATP-dependent protease La (LON); Region: LON; smart00464 639283006631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283006632 Walker A motif; other site 639283006633 ATP binding site [chemical binding]; other site 639283006634 Walker B motif; other site 639283006635 arginine finger; other site 639283006636 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 639283006637 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 639283006638 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 639283006639 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 639283006640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283006641 Walker A motif; other site 639283006642 ATP binding site [chemical binding]; other site 639283006643 Walker B motif; other site 639283006644 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 639283006645 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 639283006646 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 639283006647 oligomer interface [polypeptide binding]; other site 639283006648 active site residues [active] 639283006649 trigger factor; Provisional; Region: tig; PRK01490 639283006650 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 639283006651 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 639283006652 Uncharacterized conserved protein [Function unknown]; Region: COG0062 639283006653 putative carbohydrate kinase; Provisional; Region: PRK10565 639283006654 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 639283006655 putative substrate binding site [chemical binding]; other site 639283006656 putative ATP binding site [chemical binding]; other site 639283006657 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 639283006658 Nitrogen regulatory protein P-II; Region: P-II; smart00938 639283006659 glutamine synthetase; Provisional; Region: glnA; PRK09469 639283006660 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 639283006661 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 639283006662 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283006663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283006664 metal binding site [ion binding]; metal-binding site 639283006665 active site 639283006666 I-site; other site 639283006667 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283006668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283006669 metal binding site [ion binding]; metal-binding site 639283006670 active site 639283006671 I-site; other site 639283006672 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 639283006673 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 639283006674 23S rRNA interface [nucleotide binding]; other site 639283006675 L3 interface [polypeptide binding]; other site 639283006676 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 639283006677 Putative phosphatase (DUF442); Region: DUF442; cl17385 639283006678 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 639283006679 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 639283006680 homodimer interface [polypeptide binding]; other site 639283006681 substrate-cofactor binding pocket; other site 639283006682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283006683 catalytic residue [active] 639283006684 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 639283006685 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 639283006686 Glucose inhibited division protein A; Region: GIDA; pfam01134 639283006687 serine/threonine protein kinase; Provisional; Region: PRK09188 639283006688 serine/threonine protein kinase; Provisional; Region: PRK12274 639283006689 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 639283006690 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 639283006691 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 639283006692 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 639283006693 Bacterial sugar transferase; Region: Bac_transf; pfam02397 639283006694 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 639283006695 active site 639283006696 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 639283006697 O-Antigen ligase; Region: Wzy_C; cl04850 639283006698 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 639283006699 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 639283006700 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 639283006701 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 639283006702 SLBB domain; Region: SLBB; pfam10531 639283006703 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 639283006704 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 639283006705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283006706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283006707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 639283006708 dimerization interface [polypeptide binding]; other site 639283006709 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 639283006710 classical (c) SDRs; Region: SDR_c; cd05233 639283006711 NAD(P) binding site [chemical binding]; other site 639283006712 active site 639283006713 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 639283006714 classical (c) SDRs; Region: SDR_c; cd05233 639283006715 NAD(P) binding site [chemical binding]; other site 639283006716 active site 639283006717 Creatinine amidohydrolase; Region: Creatininase; pfam02633 639283006718 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 639283006719 agmatinase; Region: agmatinase; TIGR01230 639283006720 oligomer interface [polypeptide binding]; other site 639283006721 putative active site [active] 639283006722 Mn binding site [ion binding]; other site 639283006723 agmatinase; Region: agmatinase; TIGR01230 639283006724 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 639283006725 oligomer interface [polypeptide binding]; other site 639283006726 active site 639283006727 Mn binding site [ion binding]; other site 639283006728 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 639283006729 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 639283006730 dimerization interface [polypeptide binding]; other site 639283006731 DPS ferroxidase diiron center [ion binding]; other site 639283006732 ion pore; other site 639283006733 MarR family; Region: MarR_2; pfam12802 639283006734 phosphoglucomutase; Region: PLN02307 639283006735 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 639283006736 substrate binding site [chemical binding]; other site 639283006737 dimer interface [polypeptide binding]; other site 639283006738 active site 639283006739 metal binding site [ion binding]; metal-binding site 639283006740 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 639283006741 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 639283006742 active site 639283006743 dimer interface [polypeptide binding]; other site 639283006744 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 639283006745 dimer interface [polypeptide binding]; other site 639283006746 active site 639283006747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283006748 PAS domain; Region: PAS_9; pfam13426 639283006749 putative active site [active] 639283006750 heme pocket [chemical binding]; other site 639283006751 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 639283006752 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 639283006753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283006754 dimer interface [polypeptide binding]; other site 639283006755 phosphorylation site [posttranslational modification] 639283006756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283006757 ATP binding site [chemical binding]; other site 639283006758 Mg2+ binding site [ion binding]; other site 639283006759 G-X-G motif; other site 639283006760 Response regulator receiver domain; Region: Response_reg; pfam00072 639283006761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283006762 active site 639283006763 phosphorylation site [posttranslational modification] 639283006764 intermolecular recognition site; other site 639283006765 dimerization interface [polypeptide binding]; other site 639283006766 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 639283006767 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 639283006768 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 639283006769 catalytic core [active] 639283006770 YcjX-like family, DUF463; Region: DUF463; pfam04317 639283006771 hypothetical protein; Provisional; Region: PRK05415 639283006772 Domain of unknown function (DUF697); Region: DUF697; cl12064 639283006773 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 639283006774 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283006775 catalytic loop [active] 639283006776 iron binding site [ion binding]; other site 639283006777 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 639283006778 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 639283006779 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 639283006780 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283006781 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283006782 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 639283006783 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 639283006784 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 639283006785 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 639283006786 inhibitor-cofactor binding pocket; inhibition site 639283006787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283006788 catalytic residue [active] 639283006789 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 639283006790 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 639283006791 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 639283006792 Bacterial SH3 domain; Region: SH3_3; pfam08239 639283006793 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 639283006794 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 639283006795 active site 639283006796 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 639283006797 active site 639283006798 nucleophile elbow; other site 639283006799 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 639283006800 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 639283006801 FMN binding site [chemical binding]; other site 639283006802 active site 639283006803 substrate binding site [chemical binding]; other site 639283006804 catalytic residue [active] 639283006805 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 639283006806 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 639283006807 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 639283006808 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 639283006809 PAS domain S-box; Region: sensory_box; TIGR00229 639283006810 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283006811 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283006812 metal binding site [ion binding]; metal-binding site 639283006813 active site 639283006814 I-site; other site 639283006815 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 639283006816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 639283006817 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283006818 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 639283006819 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 639283006820 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 639283006821 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 639283006822 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 639283006823 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 639283006824 glutamine binding [chemical binding]; other site 639283006825 catalytic triad [active] 639283006826 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 639283006827 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 639283006828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283006829 catalytic residue [active] 639283006830 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 639283006831 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 639283006832 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 639283006833 2-isopropylmalate synthase; Validated; Region: PRK00915 639283006834 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 639283006835 active site 639283006836 catalytic residues [active] 639283006837 metal binding site [ion binding]; metal-binding site 639283006838 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 639283006839 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 639283006840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283006841 putative substrate translocation pore; other site 639283006842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283006843 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 639283006844 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283006845 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 639283006846 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283006847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283006848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283006849 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 639283006850 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 639283006851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283006852 S-adenosylmethionine binding site [chemical binding]; other site 639283006853 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 639283006854 manganese transport protein MntH; Reviewed; Region: PRK00701 639283006855 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 639283006856 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 639283006857 Transglycosylase SLT domain; Region: SLT_2; pfam13406 639283006858 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 639283006859 N-acetyl-D-glucosamine binding site [chemical binding]; other site 639283006860 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 639283006861 GIY-YIG motif/motif A; other site 639283006862 putative active site [active] 639283006863 putative metal binding site [ion binding]; other site 639283006864 choline dehydrogenase; Validated; Region: PRK02106 639283006865 lycopene cyclase; Region: lycopene_cycl; TIGR01789 639283006866 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 639283006867 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 639283006868 hypothetical protein; Provisional; Region: PRK06132 639283006869 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283006870 PRC-barrel domain; Region: PRC; pfam05239 639283006871 Uncharacterized conserved protein [Function unknown]; Region: COG3422 639283006872 GTP-binding protein LepA; Provisional; Region: PRK05433 639283006873 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 639283006874 G1 box; other site 639283006875 putative GEF interaction site [polypeptide binding]; other site 639283006876 GTP/Mg2+ binding site [chemical binding]; other site 639283006877 Switch I region; other site 639283006878 G2 box; other site 639283006879 G3 box; other site 639283006880 Switch II region; other site 639283006881 G4 box; other site 639283006882 G5 box; other site 639283006883 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 639283006884 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 639283006885 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 639283006886 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 639283006887 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 639283006888 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 639283006889 cytosine deaminase; Validated; Region: PRK07572 639283006890 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 639283006891 active site 639283006892 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283006893 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 639283006894 TM-ABC transporter signature motif; other site 639283006895 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283006896 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 639283006897 TM-ABC transporter signature motif; other site 639283006898 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 639283006899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283006900 Walker A/P-loop; other site 639283006901 ATP binding site [chemical binding]; other site 639283006902 Q-loop/lid; other site 639283006903 ABC transporter signature motif; other site 639283006904 Walker B; other site 639283006905 D-loop; other site 639283006906 H-loop/switch region; other site 639283006907 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 639283006908 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 639283006909 putative ligand binding site [chemical binding]; other site 639283006910 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 639283006911 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 639283006912 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 639283006913 pyridoxamine kinase; Validated; Region: PRK05756 639283006914 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 639283006915 dimer interface [polypeptide binding]; other site 639283006916 pyridoxal binding site [chemical binding]; other site 639283006917 ATP binding site [chemical binding]; other site 639283006918 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283006919 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283006920 metal binding site [ion binding]; metal-binding site 639283006921 active site 639283006922 I-site; other site 639283006923 Uncharacterized conserved protein [Function unknown]; Region: COG3189 639283006924 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 639283006925 Amidase; Region: Amidase; cl11426 639283006926 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 639283006927 LssY C-terminus; Region: LssY_C; pfam14067 639283006928 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 639283006929 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 639283006930 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 639283006931 substrate binding pocket [chemical binding]; other site 639283006932 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 639283006933 B12 binding site [chemical binding]; other site 639283006934 cobalt ligand [ion binding]; other site 639283006935 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 639283006936 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 639283006937 FAD binding site [chemical binding]; other site 639283006938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283006939 dimerization interface [polypeptide binding]; other site 639283006940 putative DNA binding site [nucleotide binding]; other site 639283006941 putative Zn2+ binding site [ion binding]; other site 639283006942 Methyltransferase domain; Region: Methyltransf_31; pfam13847 639283006943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283006944 S-adenosylmethionine binding site [chemical binding]; other site 639283006945 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 639283006946 homodimer interaction site [polypeptide binding]; other site 639283006947 cofactor binding site; other site 639283006948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283006949 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283006950 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 639283006951 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 639283006952 substrate binding pocket [chemical binding]; other site 639283006953 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 639283006954 OpgC protein; Region: OpgC_C; pfam10129 639283006955 Acyltransferase family; Region: Acyl_transf_3; pfam01757 639283006956 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 639283006957 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 639283006958 active site 639283006959 oxyanion hole [active] 639283006960 catalytic triad [active] 639283006961 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 639283006962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 639283006963 S-adenosylmethionine binding site [chemical binding]; other site 639283006964 HemK family putative methylases; Region: hemK_fam; TIGR00536 639283006965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283006966 S-adenosylmethionine binding site [chemical binding]; other site 639283006967 lytic murein transglycosylase; Region: MltB_2; TIGR02283 639283006968 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 639283006969 N-acetyl-D-glucosamine binding site [chemical binding]; other site 639283006970 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283006971 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 639283006972 dimer interface [polypeptide binding]; other site 639283006973 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 639283006974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283006975 Walker A/P-loop; other site 639283006976 ATP binding site [chemical binding]; other site 639283006977 Q-loop/lid; other site 639283006978 ABC transporter signature motif; other site 639283006979 Walker B; other site 639283006980 D-loop; other site 639283006981 H-loop/switch region; other site 639283006982 ABC transporter; Region: ABC_tran_2; pfam12848 639283006983 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 639283006984 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 639283006985 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 639283006986 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 639283006987 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 639283006988 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 639283006989 phosphoinositide binding site [chemical binding]; other site 639283006990 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 639283006991 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 639283006992 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 639283006993 active site 639283006994 homotetramer interface [polypeptide binding]; other site 639283006995 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 639283006996 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 639283006997 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283006998 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283006999 metal binding site [ion binding]; metal-binding site 639283007000 active site 639283007001 I-site; other site 639283007002 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 639283007003 active site 639283007004 catalytic residues [active] 639283007005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283007006 putative substrate translocation pore; other site 639283007007 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 639283007008 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 639283007009 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 639283007010 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 639283007011 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 639283007012 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 639283007013 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 639283007014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283007015 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 639283007016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 639283007017 DNA binding residues [nucleotide binding] 639283007018 DNA primase; Validated; Region: dnaG; PRK05667 639283007019 CHC2 zinc finger; Region: zf-CHC2; pfam01807 639283007020 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 639283007021 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 639283007022 active site 639283007023 metal binding site [ion binding]; metal-binding site 639283007024 interdomain interaction site; other site 639283007025 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 639283007026 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 639283007027 AzlC protein; Region: AzlC; cl00570 639283007028 Yqey-like protein; Region: YqeY; pfam09424 639283007029 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 639283007030 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 639283007031 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 639283007032 catalytic site [active] 639283007033 subunit interface [polypeptide binding]; other site 639283007034 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 639283007035 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 639283007036 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 639283007037 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 639283007038 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 639283007039 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 639283007040 ATP-grasp domain; Region: ATP-grasp_4; cl17255 639283007041 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 639283007042 IMP binding site; other site 639283007043 dimer interface [polypeptide binding]; other site 639283007044 interdomain contacts; other site 639283007045 partial ornithine binding site; other site 639283007046 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 639283007047 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 639283007048 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 639283007049 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283007050 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 639283007051 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 639283007052 Methyltransferase domain; Region: Methyltransf_23; pfam13489 639283007053 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 639283007054 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 639283007055 Ligand binding site; other site 639283007056 metal-binding site 639283007057 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 639283007058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283007059 putative DNA binding site [nucleotide binding]; other site 639283007060 putative Zn2+ binding site [ion binding]; other site 639283007061 AsnC family; Region: AsnC_trans_reg; pfam01037 639283007062 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 639283007063 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 639283007064 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283007065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283007066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283007067 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 639283007068 putative effector binding pocket; other site 639283007069 dimerization interface [polypeptide binding]; other site 639283007070 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 639283007071 Protein of unknown function (DUF992); Region: DUF992; pfam06186 639283007072 aspartate aminotransferase; Provisional; Region: PRK05764 639283007073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283007074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283007075 homodimer interface [polypeptide binding]; other site 639283007076 catalytic residue [active] 639283007077 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 639283007078 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 639283007079 putative C-terminal domain interface [polypeptide binding]; other site 639283007080 putative GSH binding site (G-site) [chemical binding]; other site 639283007081 putative dimer interface [polypeptide binding]; other site 639283007082 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 639283007083 N-terminal domain interface [polypeptide binding]; other site 639283007084 dimer interface [polypeptide binding]; other site 639283007085 substrate binding pocket (H-site) [chemical binding]; other site 639283007086 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 639283007087 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 639283007088 Protein of unknown function, DUF486; Region: DUF486; cl01236 639283007089 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 639283007090 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 639283007091 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 639283007092 N-terminal plug; other site 639283007093 ligand-binding site [chemical binding]; other site 639283007094 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 639283007095 Sel1-like repeats; Region: SEL1; smart00671 639283007096 Sel1-like repeats; Region: SEL1; smart00671 639283007097 Sel1-like repeats; Region: SEL1; smart00671 639283007098 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 639283007099 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 639283007100 Uncharacterized conserved protein [Function unknown]; Region: COG2968 639283007101 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 639283007102 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283007103 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283007104 Walker A/P-loop; other site 639283007105 ATP binding site [chemical binding]; other site 639283007106 Q-loop/lid; other site 639283007107 ABC transporter signature motif; other site 639283007108 Walker B; other site 639283007109 D-loop; other site 639283007110 H-loop/switch region; other site 639283007111 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283007112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283007113 dimer interface [polypeptide binding]; other site 639283007114 conserved gate region; other site 639283007115 putative PBP binding loops; other site 639283007116 ABC-ATPase subunit interface; other site 639283007117 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 639283007118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283007119 substrate binding pocket [chemical binding]; other site 639283007120 membrane-bound complex binding site; other site 639283007121 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 639283007122 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 639283007123 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 639283007124 putative deacylase active site [active] 639283007125 LemA family; Region: LemA; pfam04011 639283007126 Repair protein; Region: Repair_PSII; pfam04536 639283007127 Repair protein; Region: Repair_PSII; cl01535 639283007128 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 639283007129 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 639283007130 PhnA protein; Region: PhnA; pfam03831 639283007131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283007132 Serine hydrolase; Region: Ser_hydrolase; cl17834 639283007133 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283007134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283007135 DNA-binding site [nucleotide binding]; DNA binding site 639283007136 FCD domain; Region: FCD; pfam07729 639283007137 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283007138 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283007139 Walker A/P-loop; other site 639283007140 ATP binding site [chemical binding]; other site 639283007141 Q-loop/lid; other site 639283007142 ABC transporter signature motif; other site 639283007143 Walker B; other site 639283007144 D-loop; other site 639283007145 H-loop/switch region; other site 639283007146 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283007147 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283007148 Walker A/P-loop; other site 639283007149 ATP binding site [chemical binding]; other site 639283007150 Q-loop/lid; other site 639283007151 ABC transporter signature motif; other site 639283007152 Walker B; other site 639283007153 D-loop; other site 639283007154 H-loop/switch region; other site 639283007155 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283007156 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283007157 TM-ABC transporter signature motif; other site 639283007158 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283007159 TM-ABC transporter signature motif; other site 639283007160 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283007161 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 639283007162 putative ligand binding site [chemical binding]; other site 639283007163 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 639283007164 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 639283007165 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 639283007166 NAD binding site [chemical binding]; other site 639283007167 catalytic Zn binding site [ion binding]; other site 639283007168 substrate binding site [chemical binding]; other site 639283007169 structural Zn binding site [ion binding]; other site 639283007170 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 639283007171 Part of AAA domain; Region: AAA_19; pfam13245 639283007172 Family description; Region: UvrD_C_2; pfam13538 639283007173 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283007174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283007175 non-specific DNA binding site [nucleotide binding]; other site 639283007176 salt bridge; other site 639283007177 sequence-specific DNA binding site [nucleotide binding]; other site 639283007178 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 639283007179 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 639283007180 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 639283007181 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 639283007182 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 639283007183 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 639283007184 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 639283007185 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 639283007186 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 639283007187 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 639283007188 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 639283007189 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 639283007190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283007191 dimer interface [polypeptide binding]; other site 639283007192 phosphorylation site [posttranslational modification] 639283007193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283007194 ATP binding site [chemical binding]; other site 639283007195 Mg2+ binding site [ion binding]; other site 639283007196 G-X-G motif; other site 639283007197 Response regulator receiver domain; Region: Response_reg; pfam00072 639283007198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283007199 active site 639283007200 phosphorylation site [posttranslational modification] 639283007201 intermolecular recognition site; other site 639283007202 dimerization interface [polypeptide binding]; other site 639283007203 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 639283007204 GAF domain; Region: GAF; pfam01590 639283007205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283007206 Walker A motif; other site 639283007207 ATP binding site [chemical binding]; other site 639283007208 Walker B motif; other site 639283007209 arginine finger; other site 639283007210 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 639283007211 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 639283007212 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 639283007213 NAD(P) binding site [chemical binding]; other site 639283007214 catalytic residues [active] 639283007215 Protein of unknown function (DUF779); Region: DUF779; pfam05610 639283007216 Response regulator receiver domain; Region: Response_reg; pfam00072 639283007217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283007218 active site 639283007219 phosphorylation site [posttranslational modification] 639283007220 intermolecular recognition site; other site 639283007221 dimerization interface [polypeptide binding]; other site 639283007222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283007223 DNA binding residues [nucleotide binding] 639283007224 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 639283007225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283007226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283007227 dimer interface [polypeptide binding]; other site 639283007228 phosphorylation site [posttranslational modification] 639283007229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283007230 ATP binding site [chemical binding]; other site 639283007231 Mg2+ binding site [ion binding]; other site 639283007232 G-X-G motif; other site 639283007233 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 639283007234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283007235 active site 639283007236 phosphorylation site [posttranslational modification] 639283007237 intermolecular recognition site; other site 639283007238 dimerization interface [polypeptide binding]; other site 639283007239 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283007240 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 639283007241 putative ligand binding site [chemical binding]; other site 639283007242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283007243 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283007244 TM-ABC transporter signature motif; other site 639283007245 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283007246 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283007247 TM-ABC transporter signature motif; other site 639283007248 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 639283007249 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283007250 Walker A/P-loop; other site 639283007251 ATP binding site [chemical binding]; other site 639283007252 Q-loop/lid; other site 639283007253 ABC transporter signature motif; other site 639283007254 Walker B; other site 639283007255 D-loop; other site 639283007256 H-loop/switch region; other site 639283007257 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 639283007258 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283007259 Walker A/P-loop; other site 639283007260 ATP binding site [chemical binding]; other site 639283007261 Q-loop/lid; other site 639283007262 ABC transporter signature motif; other site 639283007263 Walker B; other site 639283007264 D-loop; other site 639283007265 H-loop/switch region; other site 639283007266 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 639283007267 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 639283007268 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 639283007269 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 639283007270 hypothetical protein; Validated; Region: PRK00124 639283007271 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 639283007272 Cupin domain; Region: Cupin_2; pfam07883 639283007273 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 639283007274 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 639283007275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 639283007276 Protein of unknown function (DUF805); Region: DUF805; pfam05656 639283007277 excinuclease ABC subunit B; Provisional; Region: PRK05298 639283007278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 639283007279 ATP binding site [chemical binding]; other site 639283007280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 639283007281 nucleotide binding region [chemical binding]; other site 639283007282 ATP-binding site [chemical binding]; other site 639283007283 Ultra-violet resistance protein B; Region: UvrB; pfam12344 639283007284 UvrB/uvrC motif; Region: UVR; pfam02151 639283007285 Isochorismatase family; Region: Isochorismatase; pfam00857 639283007286 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 639283007287 catalytic triad [active] 639283007288 conserved cis-peptide bond; other site 639283007289 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 639283007290 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 639283007291 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 639283007292 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283007293 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283007294 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 639283007295 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 639283007296 B1 nucleotide binding pocket [chemical binding]; other site 639283007297 B2 nucleotide binding pocket [chemical binding]; other site 639283007298 CAS motifs; other site 639283007299 active site 639283007300 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 639283007301 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 639283007302 DNA-binding site [nucleotide binding]; DNA binding site 639283007303 RNA-binding motif; other site 639283007304 putative glutathione S-transferase; Provisional; Region: PRK10357 639283007305 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 639283007306 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 639283007307 N-terminal domain interface [polypeptide binding]; other site 639283007308 dimer interface [polypeptide binding]; other site 639283007309 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 639283007310 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 639283007311 short chain dehydrogenase; Provisional; Region: PRK09134 639283007312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283007313 NAD(P) binding site [chemical binding]; other site 639283007314 active site 639283007315 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 639283007316 EamA-like transporter family; Region: EamA; pfam00892 639283007317 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 639283007318 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 639283007319 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 639283007320 GIY-YIG motif/motif A; other site 639283007321 active site 639283007322 catalytic site [active] 639283007323 putative DNA binding site [nucleotide binding]; other site 639283007324 metal binding site [ion binding]; metal-binding site 639283007325 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 639283007326 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 639283007327 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 639283007328 MoaE interaction surface [polypeptide binding]; other site 639283007329 MoeB interaction surface [polypeptide binding]; other site 639283007330 thiocarboxylated glycine; other site 639283007331 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 639283007332 MoaE homodimer interface [polypeptide binding]; other site 639283007333 MoaD interaction [polypeptide binding]; other site 639283007334 active site residues [active] 639283007335 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 639283007336 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 639283007337 homodimer interface [polypeptide binding]; other site 639283007338 substrate-cofactor binding pocket; other site 639283007339 catalytic residue [active] 639283007340 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 639283007341 MarR family; Region: MarR_2; pfam12802 639283007342 MarR family; Region: MarR_2; cl17246 639283007343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283007344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283007345 active site 639283007346 phosphorylation site [posttranslational modification] 639283007347 intermolecular recognition site; other site 639283007348 dimerization interface [polypeptide binding]; other site 639283007349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283007350 DNA binding site [nucleotide binding] 639283007351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283007352 HAMP domain; Region: HAMP; pfam00672 639283007353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283007354 dimer interface [polypeptide binding]; other site 639283007355 phosphorylation site [posttranslational modification] 639283007356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283007357 ATP binding site [chemical binding]; other site 639283007358 Mg2+ binding site [ion binding]; other site 639283007359 G-X-G motif; other site 639283007360 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 639283007361 dimer interface [polypeptide binding]; other site 639283007362 putative tRNA-binding site [nucleotide binding]; other site 639283007363 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 639283007364 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 639283007365 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 639283007366 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 639283007367 Membrane fusogenic activity; Region: BMFP; pfam04380 639283007368 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 639283007369 Uncharacterized conserved protein [Function unknown]; Region: COG1565 639283007370 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 639283007371 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 639283007372 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 639283007373 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 639283007374 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 639283007375 active site 639283007376 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 639283007377 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 639283007378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283007379 active site 639283007380 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 639283007381 Autotransporter beta-domain; Region: Autotransporter; smart00869 639283007382 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 639283007383 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 639283007384 5S rRNA interface [nucleotide binding]; other site 639283007385 CTC domain interface [polypeptide binding]; other site 639283007386 L16 interface [polypeptide binding]; other site 639283007387 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 639283007388 putative active site [active] 639283007389 catalytic residue [active] 639283007390 GTP-binding protein YchF; Reviewed; Region: PRK09601 639283007391 YchF GTPase; Region: YchF; cd01900 639283007392 G1 box; other site 639283007393 GTP/Mg2+ binding site [chemical binding]; other site 639283007394 Switch I region; other site 639283007395 G2 box; other site 639283007396 Switch II region; other site 639283007397 G3 box; other site 639283007398 G4 box; other site 639283007399 G5 box; other site 639283007400 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 639283007401 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 639283007402 putative active site [active] 639283007403 putative catalytic site [active] 639283007404 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 639283007405 putative active site [active] 639283007406 putative catalytic site [active] 639283007407 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 639283007408 cytochrome b; Provisional; Region: CYTB; MTH00191 639283007409 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 639283007410 Qi binding site; other site 639283007411 intrachain domain interface; other site 639283007412 interchain domain interface [polypeptide binding]; other site 639283007413 heme bH binding site [chemical binding]; other site 639283007414 heme bL binding site [chemical binding]; other site 639283007415 Qo binding site; other site 639283007416 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 639283007417 interchain domain interface [polypeptide binding]; other site 639283007418 intrachain domain interface; other site 639283007419 Qi binding site; other site 639283007420 Qo binding site; other site 639283007421 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 639283007422 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 639283007423 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 639283007424 [2Fe-2S] cluster binding site [ion binding]; other site 639283007425 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 639283007426 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 639283007427 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 639283007428 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 639283007429 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 639283007430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283007431 Walker A/P-loop; other site 639283007432 ATP binding site [chemical binding]; other site 639283007433 Q-loop/lid; other site 639283007434 ABC transporter signature motif; other site 639283007435 Walker B; other site 639283007436 D-loop; other site 639283007437 H-loop/switch region; other site 639283007438 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 639283007439 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 639283007440 active site 639283007441 NTP binding site [chemical binding]; other site 639283007442 metal binding triad [ion binding]; metal-binding site 639283007443 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 639283007444 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 639283007445 putative active site [active] 639283007446 putative CoA binding site [chemical binding]; other site 639283007447 nudix motif; other site 639283007448 metal binding site [ion binding]; metal-binding site 639283007449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 639283007450 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 639283007451 MoxR-like ATPases [General function prediction only]; Region: COG0714 639283007452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 639283007453 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 639283007454 Protein of unknown function DUF58; Region: DUF58; pfam01882 639283007455 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 639283007456 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 639283007457 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 639283007458 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 639283007459 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 639283007460 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 639283007461 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 639283007462 folate binding site [chemical binding]; other site 639283007463 NADP+ binding site [chemical binding]; other site 639283007464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 639283007465 PAS domain; Region: PAS; smart00091 639283007466 PAS fold; Region: PAS_7; pfam12860 639283007467 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283007468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283007469 metal binding site [ion binding]; metal-binding site 639283007470 active site 639283007471 I-site; other site 639283007472 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 639283007473 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 639283007474 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 639283007475 Ligand Binding Site [chemical binding]; other site 639283007476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283007477 S-adenosylmethionine binding site [chemical binding]; other site 639283007478 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 639283007479 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 639283007480 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 639283007481 putative dimer interface [polypeptide binding]; other site 639283007482 N-terminal domain interface [polypeptide binding]; other site 639283007483 putative substrate binding pocket (H-site) [chemical binding]; other site 639283007484 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 639283007485 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 639283007486 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283007487 active site 639283007488 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 639283007489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283007490 Walker A/P-loop; other site 639283007491 ATP binding site [chemical binding]; other site 639283007492 Q-loop/lid; other site 639283007493 ABC transporter signature motif; other site 639283007494 Walker B; other site 639283007495 D-loop; other site 639283007496 H-loop/switch region; other site 639283007497 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 639283007498 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 639283007499 Walker A/P-loop; other site 639283007500 ATP binding site [chemical binding]; other site 639283007501 Q-loop/lid; other site 639283007502 ABC transporter signature motif; other site 639283007503 Walker B; other site 639283007504 D-loop; other site 639283007505 H-loop/switch region; other site 639283007506 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 639283007507 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 639283007508 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 639283007509 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 639283007510 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 639283007511 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 639283007512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283007513 DNA-binding site [nucleotide binding]; DNA binding site 639283007514 UTRA domain; Region: UTRA; pfam07702 639283007515 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 639283007516 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 639283007517 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 639283007518 active site 639283007519 substrate binding site [chemical binding]; other site 639283007520 FMN binding site [chemical binding]; other site 639283007521 putative catalytic residues [active] 639283007522 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 639283007523 active site 639283007524 metal binding site [ion binding]; metal-binding site 639283007525 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 639283007526 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 639283007527 nudix motif; other site 639283007528 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 639283007529 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 639283007530 PAS domain S-box; Region: sensory_box; TIGR00229 639283007531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283007532 putative active site [active] 639283007533 heme pocket [chemical binding]; other site 639283007534 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283007535 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283007536 metal binding site [ion binding]; metal-binding site 639283007537 active site 639283007538 I-site; other site 639283007539 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283007540 Class I aldolases; Region: Aldolase_Class_I; cl17187 639283007541 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 639283007542 catalytic residue [active] 639283007543 BA14K-like protein; Region: BA14K; pfam07886 639283007544 Domain of unknown function (DUF336); Region: DUF336; cl01249 639283007545 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 639283007546 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 639283007547 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 639283007548 DctM-like transporters; Region: DctM; pfam06808 639283007549 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 639283007550 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 639283007551 FAD binding domain; Region: FAD_binding_4; pfam01565 639283007552 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 639283007553 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 639283007554 homodimer interface [polypeptide binding]; other site 639283007555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283007556 catalytic residue [active] 639283007557 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283007558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283007559 DNA-binding site [nucleotide binding]; DNA binding site 639283007560 FCD domain; Region: FCD; pfam07729 639283007561 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 639283007562 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 639283007563 Predicted transcriptional regulators [Transcription]; Region: COG1733 639283007564 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 639283007565 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 639283007566 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283007567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283007568 DNA-binding site [nucleotide binding]; DNA binding site 639283007569 FCD domain; Region: FCD; pfam07729 639283007570 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 639283007571 CoA-transferase family III; Region: CoA_transf_3; pfam02515 639283007572 enoyl-CoA hydratase; Provisional; Region: PRK06144 639283007573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 639283007574 substrate binding site [chemical binding]; other site 639283007575 oxyanion hole (OAH) forming residues; other site 639283007576 trimer interface [polypeptide binding]; other site 639283007577 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 639283007578 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283007579 substrate binding pocket [chemical binding]; other site 639283007580 membrane-bound complex binding site; other site 639283007581 hinge residues; other site 639283007582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283007583 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283007584 xylose isomerase; Provisional; Region: PRK05474 639283007585 xylose isomerase; Region: xylose_isom_A; TIGR02630 639283007586 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 639283007587 N- and C-terminal domain interface [polypeptide binding]; other site 639283007588 D-xylulose kinase; Region: XylB; TIGR01312 639283007589 active site 639283007590 MgATP binding site [chemical binding]; other site 639283007591 catalytic site [active] 639283007592 metal binding site [ion binding]; metal-binding site 639283007593 xylulose binding site [chemical binding]; other site 639283007594 homodimer interface [polypeptide binding]; other site 639283007595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 639283007596 DNA binding site [nucleotide binding] 639283007597 domain linker motif; other site 639283007598 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 639283007599 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 639283007600 putative ligand binding site [chemical binding]; other site 639283007601 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 639283007602 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 639283007603 putative ligand binding site [chemical binding]; other site 639283007604 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283007605 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283007606 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283007607 TM-ABC transporter signature motif; other site 639283007608 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283007609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283007610 Walker A/P-loop; other site 639283007611 ATP binding site [chemical binding]; other site 639283007612 Q-loop/lid; other site 639283007613 ABC transporter signature motif; other site 639283007614 Walker B; other site 639283007615 D-loop; other site 639283007616 H-loop/switch region; other site 639283007617 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 639283007618 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 639283007619 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 639283007620 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 639283007621 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 639283007622 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 639283007623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283007624 Walker A/P-loop; other site 639283007625 ATP binding site [chemical binding]; other site 639283007626 Q-loop/lid; other site 639283007627 ABC transporter signature motif; other site 639283007628 Walker B; other site 639283007629 D-loop; other site 639283007630 H-loop/switch region; other site 639283007631 TOBE domain; Region: TOBE; cl01440 639283007632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283007633 dimer interface [polypeptide binding]; other site 639283007634 conserved gate region; other site 639283007635 putative PBP binding loops; other site 639283007636 ABC-ATPase subunit interface; other site 639283007637 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 639283007638 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283007639 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 639283007640 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 639283007641 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 639283007642 active site 639283007643 catalytic site [active] 639283007644 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 639283007645 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 639283007646 glycogen synthase; Provisional; Region: PRK14099 639283007647 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 639283007648 ADP-binding pocket [chemical binding]; other site 639283007649 homodimer interface [polypeptide binding]; other site 639283007650 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 639283007651 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 639283007652 ligand binding site; other site 639283007653 oligomer interface; other site 639283007654 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 639283007655 dimer interface [polypeptide binding]; other site 639283007656 N-terminal domain interface [polypeptide binding]; other site 639283007657 sulfate 1 binding site; other site 639283007658 glycogen branching enzyme; Provisional; Region: PRK05402 639283007659 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 639283007660 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 639283007661 active site 639283007662 catalytic site [active] 639283007663 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 639283007664 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 639283007665 homodimer interface [polypeptide binding]; other site 639283007666 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 639283007667 active site pocket [active] 639283007668 Protein of unknown function (DUF423); Region: DUF423; cl01008 639283007669 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 639283007670 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 639283007671 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 639283007672 active site 639283007673 SAM binding site [chemical binding]; other site 639283007674 homodimer interface [polypeptide binding]; other site 639283007675 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 639283007676 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 639283007677 active site 639283007678 putative homodimer interface [polypeptide binding]; other site 639283007679 SAM binding site [chemical binding]; other site 639283007680 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 639283007681 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 639283007682 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 639283007683 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 639283007684 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 639283007685 active site 639283007686 SAM binding site [chemical binding]; other site 639283007687 homodimer interface [polypeptide binding]; other site 639283007688 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 639283007689 active site 639283007690 SAM binding site [chemical binding]; other site 639283007691 homodimer interface [polypeptide binding]; other site 639283007692 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 639283007693 Precorrin-8X methylmutase; Region: CbiC; pfam02570 639283007694 precorrin-3B synthase; Region: CobG; TIGR02435 639283007695 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 639283007696 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 639283007697 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 639283007698 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 639283007699 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 639283007700 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 639283007701 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 639283007702 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 639283007703 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 639283007704 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 639283007705 homotrimer interface [polypeptide binding]; other site 639283007706 Walker A motif; other site 639283007707 GTP binding site [chemical binding]; other site 639283007708 Walker B motif; other site 639283007709 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 639283007710 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 639283007711 TM2 domain; Region: TM2; cl00984 639283007712 cobyric acid synthase; Provisional; Region: PRK00784 639283007713 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 639283007714 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 639283007715 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 639283007716 catalytic triad [active] 639283007717 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 639283007718 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 639283007719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 639283007720 ATP binding site [chemical binding]; other site 639283007721 putative Mg++ binding site [ion binding]; other site 639283007722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 639283007723 nucleotide binding region [chemical binding]; other site 639283007724 ATP-binding site [chemical binding]; other site 639283007725 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 639283007726 HRDC domain; Region: HRDC; pfam00570 639283007727 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 639283007728 putative hydrophobic ligand binding site [chemical binding]; other site 639283007729 protein interface [polypeptide binding]; other site 639283007730 gate; other site 639283007731 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 639283007732 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283007733 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283007734 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283007735 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283007736 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283007737 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283007738 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283007739 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 639283007740 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 639283007741 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 639283007742 Walker A/P-loop; other site 639283007743 ATP binding site [chemical binding]; other site 639283007744 Q-loop/lid; other site 639283007745 ABC transporter signature motif; other site 639283007746 Walker B; other site 639283007747 D-loop; other site 639283007748 H-loop/switch region; other site 639283007749 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 639283007750 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 639283007751 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283007752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283007753 active site 639283007754 phosphorylation site [posttranslational modification] 639283007755 intermolecular recognition site; other site 639283007756 dimerization interface [polypeptide binding]; other site 639283007757 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283007758 DNA binding site [nucleotide binding] 639283007759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 639283007760 CheW-like domain; Region: CheW; pfam01584 639283007761 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 639283007762 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 639283007763 active site 639283007764 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 639283007765 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 639283007766 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 639283007767 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 639283007768 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 639283007769 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 639283007770 SnoaL-like domain; Region: SnoaL_2; pfam12680 639283007771 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 639283007772 thiamine phosphate binding site [chemical binding]; other site 639283007773 active site 639283007774 pyrophosphate binding site [ion binding]; other site 639283007775 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 639283007776 ThiS interaction site; other site 639283007777 putative active site [active] 639283007778 tetramer interface [polypeptide binding]; other site 639283007779 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 639283007780 thiS-thiF/thiG interaction site; other site 639283007781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 639283007782 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 639283007783 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 639283007784 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 639283007785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283007786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283007787 putative active site [active] 639283007788 heme pocket [chemical binding]; other site 639283007789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283007790 dimer interface [polypeptide binding]; other site 639283007791 phosphorylation site [posttranslational modification] 639283007792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283007793 ATP binding site [chemical binding]; other site 639283007794 G-X-G motif; other site 639283007795 Response regulator receiver domain; Region: Response_reg; pfam00072 639283007796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283007797 active site 639283007798 phosphorylation site [posttranslational modification] 639283007799 intermolecular recognition site; other site 639283007800 dimerization interface [polypeptide binding]; other site 639283007801 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 639283007802 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 639283007803 active site 639283007804 Serine hydrolase; Region: Ser_hydrolase; pfam06821 639283007805 MAPEG family; Region: MAPEG; cl09190 639283007806 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 639283007807 nudix motif; other site 639283007808 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 639283007809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283007810 Major Facilitator Superfamily; Region: MFS_1; pfam07690 639283007811 putative substrate translocation pore; other site 639283007812 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 639283007813 DctM-like transporters; Region: DctM; pfam06808 639283007814 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 639283007815 PRC-barrel domain; Region: PRC; pfam05239 639283007816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283007817 putative substrate translocation pore; other site 639283007818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283007819 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 639283007820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283007821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 639283007822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283007823 dimer interface [polypeptide binding]; other site 639283007824 phosphorylation site [posttranslational modification] 639283007825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283007826 ATP binding site [chemical binding]; other site 639283007827 Mg2+ binding site [ion binding]; other site 639283007828 G-X-G motif; other site 639283007829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283007830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283007831 active site 639283007832 phosphorylation site [posttranslational modification] 639283007833 intermolecular recognition site; other site 639283007834 dimerization interface [polypeptide binding]; other site 639283007835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283007836 DNA binding site [nucleotide binding] 639283007837 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 639283007838 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 639283007839 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 639283007840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283007841 catalytic residue [active] 639283007842 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 639283007843 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 639283007844 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 639283007845 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 639283007846 dimerization interface [polypeptide binding]; other site 639283007847 ligand binding site [chemical binding]; other site 639283007848 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283007849 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283007850 TM-ABC transporter signature motif; other site 639283007851 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283007852 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283007853 TM-ABC transporter signature motif; other site 639283007854 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283007855 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283007856 Walker A/P-loop; other site 639283007857 ATP binding site [chemical binding]; other site 639283007858 Q-loop/lid; other site 639283007859 ABC transporter signature motif; other site 639283007860 Walker B; other site 639283007861 D-loop; other site 639283007862 H-loop/switch region; other site 639283007863 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283007864 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283007865 Walker A/P-loop; other site 639283007866 ATP binding site [chemical binding]; other site 639283007867 Q-loop/lid; other site 639283007868 ABC transporter signature motif; other site 639283007869 Walker B; other site 639283007870 D-loop; other site 639283007871 H-loop/switch region; other site 639283007872 acetylornithine deacetylase; Provisional; Region: PRK07522 639283007873 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 639283007874 metal binding site [ion binding]; metal-binding site 639283007875 putative dimer interface [polypeptide binding]; other site 639283007876 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 639283007877 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 639283007878 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 639283007879 homotrimer interaction site [polypeptide binding]; other site 639283007880 putative active site [active] 639283007881 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 639283007882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283007883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283007884 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 639283007885 putative substrate binding pocket [chemical binding]; other site 639283007886 dimerization interface [polypeptide binding]; other site 639283007887 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 639283007888 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 639283007889 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 639283007890 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 639283007891 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 639283007892 dimer interface [polypeptide binding]; other site 639283007893 active site 639283007894 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 639283007895 substrate binding site [chemical binding]; other site 639283007896 catalytic residue [active] 639283007897 hypothetical protein; Provisional; Region: PRK06815 639283007898 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 639283007899 tetramer interface [polypeptide binding]; other site 639283007900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283007901 catalytic residue [active] 639283007902 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 639283007903 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283007904 substrate binding pocket [chemical binding]; other site 639283007905 membrane-bound complex binding site; other site 639283007906 hinge residues; other site 639283007907 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 639283007908 active site 639283007909 catalytic residues [active] 639283007910 DNA binding site [nucleotide binding] 639283007911 Int/Topo IB signature motif; other site 639283007912 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 639283007913 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 639283007914 MobA/MobL family; Region: MobA_MobL; pfam03389 639283007915 AAA domain; Region: AAA_30; pfam13604 639283007916 Family description; Region: UvrD_C_2; pfam13538 639283007917 Conjugal transfer protein TraD; Region: TraD; pfam06412 639283007918 Protein of unknown function DUF45; Region: DUF45; pfam01863 639283007919 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 639283007920 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 639283007921 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 639283007922 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 639283007923 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 639283007924 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 639283007925 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 639283007926 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 639283007927 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 639283007928 Virulence protein [General function prediction only]; Region: COG3943 639283007929 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 639283007930 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 639283007931 HsdM N-terminal domain; Region: HsdM_N; pfam12161 639283007932 Methyltransferase domain; Region: Methyltransf_26; pfam13659 639283007933 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 639283007934 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 639283007935 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 639283007936 LabA_like proteins; Region: LabA_like; cd06167 639283007937 putative metal binding site [ion binding]; other site 639283007938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 639283007939 non-specific DNA binding site [nucleotide binding]; other site 639283007940 salt bridge; other site 639283007941 sequence-specific DNA binding site [nucleotide binding]; other site 639283007942 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283007943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283007944 non-specific DNA binding site [nucleotide binding]; other site 639283007945 salt bridge; other site 639283007946 sequence-specific DNA binding site [nucleotide binding]; other site 639283007947 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 639283007948 HsdM N-terminal domain; Region: HsdM_N; pfam12161 639283007949 Methyltransferase domain; Region: Methyltransf_26; pfam13659 639283007950 Protein of unknown function DUF262; Region: DUF262; pfam03235 639283007951 Uncharacterized conserved protein [Function unknown]; Region: COG1479 639283007952 Protein of unknown function DUF262; Region: DUF262; pfam03235 639283007953 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 639283007954 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 639283007955 DEAD-like helicases superfamily; Region: DEXDc; smart00487 639283007956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 639283007957 ATP binding site [chemical binding]; other site 639283007958 putative Mg++ binding site [ion binding]; other site 639283007959 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 639283007960 HNH endonuclease; Region: HNH_2; pfam13391 639283007961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 639283007962 salt bridge; other site 639283007963 non-specific DNA binding site [nucleotide binding]; other site 639283007964 sequence-specific DNA binding site [nucleotide binding]; other site 639283007965 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 639283007966 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 639283007967 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 639283007968 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 639283007969 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 639283007970 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 639283007971 Autotransporter beta-domain; Region: Autotransporter; pfam03797 639283007972 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 639283007973 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 639283007974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283007975 DNA binding residues [nucleotide binding] 639283007976 dimerization interface [polypeptide binding]; other site 639283007977 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 639283007978 Uncharacterized conserved protein [Function unknown]; Region: COG2128 639283007979 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 639283007980 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 639283007981 oxidoreductase; Provisional; Region: PRK06196 639283007982 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 639283007983 putative NAD(P) binding site [chemical binding]; other site 639283007984 active site 639283007985 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 639283007986 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 639283007987 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283007988 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283007989 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 639283007990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283007991 NADH(P)-binding; Region: NAD_binding_10; pfam13460 639283007992 NAD(P) binding site [chemical binding]; other site 639283007993 active site 639283007994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283007995 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283007996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283007997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283007998 NADH(P)-binding; Region: NAD_binding_10; pfam13460 639283007999 NAD(P) binding site [chemical binding]; other site 639283008000 active site 639283008001 MarC family integral membrane protein; Region: MarC; cl00919 639283008002 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 639283008003 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 639283008004 catalytic residues [active] 639283008005 catalytic nucleophile [active] 639283008006 Recombinase; Region: Recombinase; pfam07508 639283008007 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 639283008008 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 639283008009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 639283008010 RNA binding surface [nucleotide binding]; other site 639283008011 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 639283008012 active site 639283008013 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 639283008014 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 639283008015 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283008016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 639283008017 DNA binding residues [nucleotide binding] 639283008018 FOG: CBS domain [General function prediction only]; Region: COG0517 639283008019 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 639283008020 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 639283008021 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 639283008022 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 639283008023 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 639283008024 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 639283008025 ligand binding site [chemical binding]; other site 639283008026 homodimer interface [polypeptide binding]; other site 639283008027 NAD(P) binding site [chemical binding]; other site 639283008028 trimer interface B [polypeptide binding]; other site 639283008029 trimer interface A [polypeptide binding]; other site 639283008030 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 639283008031 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 639283008032 ABC1 family; Region: ABC1; pfam03109 639283008033 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 639283008034 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 639283008035 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283008036 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 639283008037 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 639283008038 active site 639283008039 Zn binding site [ion binding]; other site 639283008040 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 639283008041 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 639283008042 Response regulator receiver domain; Region: Response_reg; pfam00072 639283008043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283008044 active site 639283008045 phosphorylation site [posttranslational modification] 639283008046 intermolecular recognition site; other site 639283008047 dimerization interface [polypeptide binding]; other site 639283008048 N-formylglutamate amidohydrolase; Region: FGase; cl01522 639283008049 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 639283008050 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 639283008051 active site 639283008052 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 639283008053 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 639283008054 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 639283008055 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 639283008056 putative dimer interface [polypeptide binding]; other site 639283008057 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 639283008058 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 639283008059 active site 639283008060 dimer interface [polypeptide binding]; other site 639283008061 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 639283008062 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 639283008063 active site 639283008064 FMN binding site [chemical binding]; other site 639283008065 substrate binding site [chemical binding]; other site 639283008066 3Fe-4S cluster binding site [ion binding]; other site 639283008067 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 639283008068 domain interface; other site 639283008069 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 639283008070 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 639283008071 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 639283008072 active site 639283008073 catalytic triad [active] 639283008074 oxyanion hole [active] 639283008075 Transglycosylase SLT domain; Region: SLT_2; pfam13406 639283008076 murein hydrolase B; Provisional; Region: PRK10760; cl17906 639283008077 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283008078 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 639283008079 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 639283008080 active site 639283008081 tetramer interface; other site 639283008082 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 639283008083 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 639283008084 inhibitor site; inhibition site 639283008085 active site 639283008086 dimer interface [polypeptide binding]; other site 639283008087 catalytic residue [active] 639283008088 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 639283008089 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 639283008090 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 639283008091 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 639283008092 Clp amino terminal domain; Region: Clp_N; pfam02861 639283008093 Clp amino terminal domain; Region: Clp_N; pfam02861 639283008094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283008095 Walker A motif; other site 639283008096 ATP binding site [chemical binding]; other site 639283008097 Walker B motif; other site 639283008098 arginine finger; other site 639283008099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283008100 Walker A motif; other site 639283008101 ATP binding site [chemical binding]; other site 639283008102 Walker B motif; other site 639283008103 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 639283008104 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 639283008105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283008106 S-adenosylmethionine binding site [chemical binding]; other site 639283008107 aspartate kinase; Reviewed; Region: PRK06635 639283008108 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 639283008109 putative nucleotide binding site [chemical binding]; other site 639283008110 putative catalytic residues [active] 639283008111 putative Mg ion binding site [ion binding]; other site 639283008112 putative aspartate binding site [chemical binding]; other site 639283008113 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 639283008114 putative allosteric regulatory site; other site 639283008115 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 639283008116 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 639283008117 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 639283008118 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 639283008119 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 639283008120 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 639283008121 peptide chain release factor 1; Validated; Region: prfA; PRK00591 639283008122 This domain is found in peptide chain release factors; Region: PCRF; smart00937 639283008123 RF-1 domain; Region: RF-1; pfam00472 639283008124 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 639283008125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283008126 S-adenosylmethionine binding site [chemical binding]; other site 639283008127 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 639283008128 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 639283008129 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 639283008130 MOSC domain; Region: MOSC; pfam03473 639283008131 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 639283008132 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 639283008133 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 639283008134 Uncharacterized conserved protein [Function unknown]; Region: COG3339 639283008135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 639283008136 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 639283008137 EamA-like transporter family; Region: EamA; pfam00892 639283008138 aromatic amino acid exporter; Provisional; Region: PRK11689 639283008139 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 639283008140 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 639283008141 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 639283008142 NAD(P) binding site [chemical binding]; other site 639283008143 homotetramer interface [polypeptide binding]; other site 639283008144 homodimer interface [polypeptide binding]; other site 639283008145 active site 639283008146 putative acyltransferase; Provisional; Region: PRK05790 639283008147 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 639283008148 dimer interface [polypeptide binding]; other site 639283008149 active site 639283008150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 639283008151 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 639283008152 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 639283008153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283008154 metal binding site [ion binding]; metal-binding site 639283008155 active site 639283008156 I-site; other site 639283008157 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283008158 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 639283008159 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 639283008160 Transglycosylase; Region: Transgly; pfam00912 639283008161 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 639283008162 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 639283008163 substrate binding pocket [chemical binding]; other site 639283008164 chain length determination region; other site 639283008165 substrate-Mg2+ binding site; other site 639283008166 catalytic residues [active] 639283008167 aspartate-rich region 1; other site 639283008168 active site lid residues [active] 639283008169 aspartate-rich region 2; other site 639283008170 tartrate dehydrogenase; Region: TTC; TIGR02089 639283008171 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 639283008172 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 639283008173 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 639283008174 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 639283008175 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 639283008176 dimer interface [polypeptide binding]; other site 639283008177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283008178 active site 639283008179 metal binding site [ion binding]; metal-binding site 639283008180 glutathione binding site [chemical binding]; other site 639283008181 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 639283008182 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 639283008183 homotrimer interaction site [polypeptide binding]; other site 639283008184 putative active site [active] 639283008185 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 639283008186 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 639283008187 substrate binding site [chemical binding]; other site 639283008188 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 639283008189 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 639283008190 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 639283008191 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 639283008192 substrate binding site [chemical binding]; other site 639283008193 ligand binding site [chemical binding]; other site 639283008194 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 639283008195 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 639283008196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283008197 short chain dehydrogenase; Provisional; Region: PRK12939 639283008198 NAD(P) binding site [chemical binding]; other site 639283008199 active site 639283008200 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 639283008201 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 639283008202 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 639283008203 RimM N-terminal domain; Region: RimM; pfam01782 639283008204 PRC-barrel domain; Region: PRC; pfam05239 639283008205 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 639283008206 signal recognition particle protein; Provisional; Region: PRK10867 639283008207 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 639283008208 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 639283008209 P loop; other site 639283008210 GTP binding site [chemical binding]; other site 639283008211 Signal peptide binding domain; Region: SRP_SPB; pfam02978 639283008212 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 639283008213 pyruvate kinase; Validated; Region: PRK08187 639283008214 domain interfaces; other site 639283008215 active site 639283008216 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 639283008217 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 639283008218 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 639283008219 trimer interface [polypeptide binding]; other site 639283008220 putative metal binding site [ion binding]; other site 639283008221 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 639283008222 putative trimer interface [polypeptide binding]; other site 639283008223 putative CoA binding site [chemical binding]; other site 639283008224 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 639283008225 ArgK protein; Region: ArgK; pfam03308 639283008226 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 639283008227 Walker A; other site 639283008228 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 639283008229 G4 box; other site 639283008230 G5 box; other site 639283008231 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 639283008232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 639283008233 acyl-activating enzyme (AAE) consensus motif; other site 639283008234 AMP binding site [chemical binding]; other site 639283008235 active site 639283008236 CoA binding site [chemical binding]; other site 639283008237 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 639283008238 B12 binding site [chemical binding]; other site 639283008239 cobalt ligand [ion binding]; other site 639283008240 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283008241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283008242 DNA-binding site [nucleotide binding]; DNA binding site 639283008243 FCD domain; Region: FCD; pfam07729 639283008244 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 639283008245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283008246 EthD domain; Region: EthD; cl17553 639283008247 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283008248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283008249 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 639283008250 dimerization interface [polypeptide binding]; other site 639283008251 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 639283008252 heme exporter protein CcmC; Region: ccmC; TIGR01191 639283008253 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 639283008254 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 639283008255 catalytic residues [active] 639283008256 central insert; other site 639283008257 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 639283008258 nitrilase; Region: PLN02798 639283008259 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 639283008260 putative active site [active] 639283008261 catalytic triad [active] 639283008262 dimer interface [polypeptide binding]; other site 639283008263 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 639283008264 GSH binding site [chemical binding]; other site 639283008265 catalytic residues [active] 639283008266 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 639283008267 Methyltransferase domain; Region: Methyltransf_23; pfam13489 639283008268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 639283008269 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 639283008270 active site 639283008271 8-oxo-dGMP binding site [chemical binding]; other site 639283008272 nudix motif; other site 639283008273 metal binding site [ion binding]; metal-binding site 639283008274 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 639283008275 heterotetramer interface [polypeptide binding]; other site 639283008276 active site pocket [active] 639283008277 cleavage site 639283008278 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 639283008279 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 639283008280 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 639283008281 ATP binding site [chemical binding]; other site 639283008282 putative Mg++ binding site [ion binding]; other site 639283008283 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 639283008284 SEC-C motif; Region: SEC-C; pfam02810 639283008285 SnoaL-like domain; Region: SnoaL_3; pfam13474 639283008286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 639283008287 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 639283008288 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 639283008289 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 639283008290 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 639283008291 active site 639283008292 DNA binding site [nucleotide binding] 639283008293 Int/Topo IB signature motif; other site 639283008294 shikimate kinase; Provisional; Region: PRK13946 639283008295 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 639283008296 ADP binding site [chemical binding]; other site 639283008297 magnesium binding site [ion binding]; other site 639283008298 putative shikimate binding site; other site 639283008299 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 639283008300 active site 639283008301 dimer interface [polypeptide binding]; other site 639283008302 metal binding site [ion binding]; metal-binding site 639283008303 FOG: CBS domain [General function prediction only]; Region: COG0517 639283008304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 639283008305 Transporter associated domain; Region: CorC_HlyC; smart01091 639283008306 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 639283008307 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 639283008308 HSP70 interaction site [polypeptide binding]; other site 639283008309 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 639283008310 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 639283008311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 639283008312 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 639283008313 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 639283008314 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 639283008315 metal ion-dependent adhesion site (MIDAS); other site 639283008316 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 639283008317 HemY protein N-terminus; Region: HemY_N; pfam07219 639283008318 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 639283008319 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 639283008320 active site 639283008321 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 639283008322 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 639283008323 domain interfaces; other site 639283008324 active site 639283008325 UGMP family protein; Validated; Region: PRK09604 639283008326 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 639283008327 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 639283008328 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 639283008329 EVE domain; Region: EVE; pfam01878 639283008330 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 639283008331 catalytic residues [active] 639283008332 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283008333 Predicted methyltransferase [General function prediction only]; Region: COG3897 639283008334 acetyl-CoA synthetase; Provisional; Region: PRK00174 639283008335 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 639283008336 active site 639283008337 CoA binding site [chemical binding]; other site 639283008338 acyl-activating enzyme (AAE) consensus motif; other site 639283008339 AMP binding site [chemical binding]; other site 639283008340 acetate binding site [chemical binding]; other site 639283008341 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 639283008342 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 639283008343 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 639283008344 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 639283008345 purine monophosphate binding site [chemical binding]; other site 639283008346 dimer interface [polypeptide binding]; other site 639283008347 putative catalytic residues [active] 639283008348 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 639283008349 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 639283008350 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 639283008351 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 639283008352 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 639283008353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283008354 Glucokinase; Region: Glucokinase; cl17310 639283008355 glucokinase, proteobacterial type; Region: glk; TIGR00749 639283008356 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 639283008357 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 639283008358 active site 639283008359 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 639283008360 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 639283008361 active site 639283008362 nucleophile elbow; other site 639283008363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283008364 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 639283008365 NAD(P) binding site [chemical binding]; other site 639283008366 active site 639283008367 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 639283008368 metal binding site 2 [ion binding]; metal-binding site 639283008369 putative DNA binding helix; other site 639283008370 metal binding site 1 [ion binding]; metal-binding site 639283008371 dimer interface [polypeptide binding]; other site 639283008372 structural Zn2+ binding site [ion binding]; other site 639283008373 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 639283008374 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 639283008375 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 639283008376 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 639283008377 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 639283008378 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 639283008379 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 639283008380 acetoacetate decarboxylase; Provisional; Region: PRK02265 639283008381 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 639283008382 Autotransporter beta-domain; Region: Autotransporter; smart00869 639283008383 FOG: WD40 repeat [General function prediction only]; Region: COG2319 639283008384 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 639283008385 structural tetrad; other site 639283008386 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 639283008387 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 639283008388 P-loop, Walker A motif; other site 639283008389 Base recognition motif; other site 639283008390 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 639283008391 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 639283008392 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 639283008393 metal binding site [ion binding]; metal-binding site 639283008394 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 639283008395 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 639283008396 putative PBP binding regions; other site 639283008397 ABC-ATPase subunit interface; other site 639283008398 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 639283008399 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 639283008400 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 639283008401 dimer interface [polypeptide binding]; other site 639283008402 substrate binding site [chemical binding]; other site 639283008403 metal binding sites [ion binding]; metal-binding site 639283008404 Creatinine amidohydrolase; Region: Creatininase; pfam02633 639283008405 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 639283008406 homotrimer interaction site [polypeptide binding]; other site 639283008407 putative active site [active] 639283008408 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 639283008409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 639283008410 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283008411 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283008412 Walker A/P-loop; other site 639283008413 ATP binding site [chemical binding]; other site 639283008414 Q-loop/lid; other site 639283008415 ABC transporter signature motif; other site 639283008416 Walker B; other site 639283008417 D-loop; other site 639283008418 H-loop/switch region; other site 639283008419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 639283008420 cytosine deaminase-like protein; Validated; Region: PRK07583 639283008421 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 639283008422 active site 639283008423 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 639283008424 FAD binding domain; Region: FAD_binding_4; pfam01565 639283008425 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 639283008426 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 639283008427 Transcriptional regulators [Transcription]; Region: MarR; COG1846 639283008428 MarR family; Region: MarR_2; pfam12802 639283008429 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 639283008430 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 639283008431 putative ligand binding site [chemical binding]; other site 639283008432 NAD binding site [chemical binding]; other site 639283008433 catalytic site [active] 639283008434 Protease inhibitor Inh; Region: Inh; pfam02974 639283008435 ParB-like nuclease domain; Region: ParB; smart00470 639283008436 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 639283008437 active site 639283008438 metal binding site [ion binding]; metal-binding site 639283008439 interdomain interaction site; other site 639283008440 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 639283008441 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 639283008442 Uncharacterized conserved protein [Function unknown]; Region: COG5489 639283008443 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283008444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283008445 non-specific DNA binding site [nucleotide binding]; other site 639283008446 salt bridge; other site 639283008447 sequence-specific DNA binding site [nucleotide binding]; other site 639283008448 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283008449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283008450 DNA-binding site [nucleotide binding]; DNA binding site 639283008451 FCD domain; Region: FCD; pfam07729 639283008452 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 639283008453 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 639283008454 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 639283008455 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 639283008456 active site 639283008457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283008458 DNA-binding site [nucleotide binding]; DNA binding site 639283008459 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283008460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283008461 non-specific DNA binding site [nucleotide binding]; other site 639283008462 salt bridge; other site 639283008463 sequence-specific DNA binding site [nucleotide binding]; other site 639283008464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 639283008465 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 639283008466 Amidase; Region: Amidase; cl11426 639283008467 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283008468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283008469 dimer interface [polypeptide binding]; other site 639283008470 conserved gate region; other site 639283008471 putative PBP binding loops; other site 639283008472 ABC-ATPase subunit interface; other site 639283008473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283008474 conserved gate region; other site 639283008475 putative PBP binding loops; other site 639283008476 ABC-ATPase subunit interface; other site 639283008477 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283008478 hypothetical protein; Provisional; Region: PRK11622 639283008479 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283008480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283008481 Walker A/P-loop; other site 639283008482 ATP binding site [chemical binding]; other site 639283008483 Q-loop/lid; other site 639283008484 ABC transporter signature motif; other site 639283008485 Walker B; other site 639283008486 D-loop; other site 639283008487 H-loop/switch region; other site 639283008488 TOBE domain; Region: TOBE_2; pfam08402 639283008489 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283008490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283008491 DNA-binding site [nucleotide binding]; DNA binding site 639283008492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283008493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283008494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283008495 dimerization interface [polypeptide binding]; other site 639283008496 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283008497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283008498 non-specific DNA binding site [nucleotide binding]; other site 639283008499 salt bridge; other site 639283008500 sequence-specific DNA binding site [nucleotide binding]; other site 639283008501 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 639283008502 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 639283008503 Helix-turn-helix domain; Region: HTH_17; cl17695 639283008504 Replication initiator protein A; Region: RPA; pfam10134 639283008505 ParA-like protein; Provisional; Region: PHA02518 639283008506 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 639283008507 P-loop; other site 639283008508 Magnesium ion binding site [ion binding]; other site 639283008509 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 639283008510 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 639283008511 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 639283008512 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 639283008513 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 639283008514 N-acetyl-D-glucosamine binding site [chemical binding]; other site 639283008515 catalytic residue [active] 639283008516 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 639283008517 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 639283008518 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 639283008519 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 639283008520 Walker A motif; other site 639283008521 ATP binding site [chemical binding]; other site 639283008522 Walker B motif; other site 639283008523 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 639283008524 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 639283008525 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283008526 catalytic residue [active] 639283008527 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 639283008528 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 639283008529 active site 639283008530 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283008531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283008532 dimer interface [polypeptide binding]; other site 639283008533 conserved gate region; other site 639283008534 putative PBP binding loops; other site 639283008535 ABC-ATPase subunit interface; other site 639283008536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283008537 dimer interface [polypeptide binding]; other site 639283008538 conserved gate region; other site 639283008539 putative PBP binding loops; other site 639283008540 ABC-ATPase subunit interface; other site 639283008541 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283008542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283008543 Walker A/P-loop; other site 639283008544 ATP binding site [chemical binding]; other site 639283008545 Q-loop/lid; other site 639283008546 ABC transporter signature motif; other site 639283008547 Walker B; other site 639283008548 D-loop; other site 639283008549 H-loop/switch region; other site 639283008550 TOBE domain; Region: TOBE_2; pfam08402 639283008551 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 639283008552 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283008553 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 639283008554 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 639283008555 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 639283008556 SnoaL-like domain; Region: SnoaL_4; pfam13577 639283008557 Transcriptional regulator [Transcription]; Region: IclR; COG1414 639283008558 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 639283008559 Bacterial transcriptional regulator; Region: IclR; pfam01614 639283008560 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 639283008561 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 639283008562 tetramerization interface [polypeptide binding]; other site 639283008563 NAD(P) binding site [chemical binding]; other site 639283008564 catalytic residues [active] 639283008565 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 639283008566 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 639283008567 DNA-binding site [nucleotide binding]; DNA binding site 639283008568 RNA-binding motif; other site 639283008569 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 639283008570 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 639283008571 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 639283008572 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 639283008573 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 639283008574 ring oligomerisation interface [polypeptide binding]; other site 639283008575 ATP/Mg binding site [chemical binding]; other site 639283008576 stacking interactions; other site 639283008577 hinge regions; other site 639283008578 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 639283008579 oligomerisation interface [polypeptide binding]; other site 639283008580 mobile loop; other site 639283008581 roof hairpin; other site 639283008582 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 639283008583 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 639283008584 DNA-binding site [nucleotide binding]; DNA binding site 639283008585 RNA-binding motif; other site 639283008586 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 639283008587 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 639283008588 Putative glucoamylase; Region: Glycoamylase; pfam10091 639283008589 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 639283008590 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 639283008591 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 639283008592 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 639283008593 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 639283008594 NAD(P) binding site [chemical binding]; other site 639283008595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283008596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283008597 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 639283008598 putative effector binding pocket; other site 639283008599 dimerization interface [polypeptide binding]; other site 639283008600 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283008601 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 639283008602 putative ligand binding site [chemical binding]; other site 639283008603 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283008604 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283008605 TM-ABC transporter signature motif; other site 639283008606 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283008607 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283008608 TM-ABC transporter signature motif; other site 639283008609 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283008610 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283008611 Walker A/P-loop; other site 639283008612 ATP binding site [chemical binding]; other site 639283008613 Q-loop/lid; other site 639283008614 ABC transporter signature motif; other site 639283008615 Walker B; other site 639283008616 D-loop; other site 639283008617 H-loop/switch region; other site 639283008618 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283008619 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283008620 Walker A/P-loop; other site 639283008621 ATP binding site [chemical binding]; other site 639283008622 Q-loop/lid; other site 639283008623 ABC transporter signature motif; other site 639283008624 Walker B; other site 639283008625 D-loop; other site 639283008626 H-loop/switch region; other site 639283008627 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 639283008628 active site 1 [active] 639283008629 dimer interface [polypeptide binding]; other site 639283008630 hexamer interface [polypeptide binding]; other site 639283008631 active site 2 [active] 639283008632 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 639283008633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283008634 active site 639283008635 phosphorylation site [posttranslational modification] 639283008636 intermolecular recognition site; other site 639283008637 dimerization interface [polypeptide binding]; other site 639283008638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283008639 DNA binding residues [nucleotide binding] 639283008640 dimerization interface [polypeptide binding]; other site 639283008641 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283008642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283008643 DNA binding site [nucleotide binding] 639283008644 Predicted ATPase [General function prediction only]; Region: COG3903 639283008645 Isochorismatase family; Region: Isochorismatase; pfam00857 639283008646 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 639283008647 catalytic triad [active] 639283008648 conserved cis-peptide bond; other site 639283008649 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 639283008650 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 639283008651 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 639283008652 Epoxide hydrolase N terminus; Region: EHN; pfam06441 639283008653 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283008654 Predicted membrane protein [Function unknown]; Region: COG2259 639283008655 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 639283008656 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 639283008657 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 639283008658 trimer interface [polypeptide binding]; other site 639283008659 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 639283008660 trimer interface [polypeptide binding]; other site 639283008661 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 639283008662 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283008663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283008664 dimer interface [polypeptide binding]; other site 639283008665 conserved gate region; other site 639283008666 putative PBP binding loops; other site 639283008667 ABC-ATPase subunit interface; other site 639283008668 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 639283008669 histidinol dehydrogenase; Region: hisD; TIGR00069 639283008670 NAD binding site [chemical binding]; other site 639283008671 dimerization interface [polypeptide binding]; other site 639283008672 product binding site; other site 639283008673 substrate binding site [chemical binding]; other site 639283008674 zinc binding site [ion binding]; other site 639283008675 catalytic residues [active] 639283008676 integrase; Provisional; Region: PRK09692 639283008677 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 639283008678 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 639283008679 active site 639283008680 DNA binding site [nucleotide binding] 639283008681 Int/Topo IB signature motif; other site 639283008682 hypothetical protein; Reviewed; Region: PRK00024 639283008683 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 639283008684 MPN+ (JAMM) motif; other site 639283008685 Zinc-binding site [ion binding]; other site 639283008686 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 639283008687 active site 639283008688 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 639283008689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283008690 Coenzyme A binding pocket [chemical binding]; other site 639283008691 aspartate aminotransferase; Provisional; Region: PRK05764 639283008692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283008693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283008694 homodimer interface [polypeptide binding]; other site 639283008695 catalytic residue [active] 639283008696 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 639283008697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283008698 NAD(P) binding site [chemical binding]; other site 639283008699 active site 639283008700 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 639283008701 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 639283008702 substrate binding site [chemical binding]; other site 639283008703 ATP binding site [chemical binding]; other site 639283008704 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 639283008705 Cation efflux family; Region: Cation_efflux; pfam01545 639283008706 Transglycosylase SLT domain; Region: SLT_2; pfam13406 639283008707 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 639283008708 N-acetyl-D-glucosamine binding site [chemical binding]; other site 639283008709 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283008710 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 639283008711 ThiC-associated domain; Region: ThiC-associated; pfam13667 639283008712 ThiC family; Region: ThiC; pfam01964 639283008713 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 639283008714 nudix motif; other site 639283008715 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 639283008716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283008717 putative substrate translocation pore; other site 639283008718 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 639283008719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283008720 putative substrate translocation pore; other site 639283008721 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283008722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283008723 DNA-binding site [nucleotide binding]; DNA binding site 639283008724 FCD domain; Region: FCD; pfam07729 639283008725 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 639283008726 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283008727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283008728 DNA-binding site [nucleotide binding]; DNA binding site 639283008729 FCD domain; Region: FCD; pfam07729 639283008730 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 639283008731 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 639283008732 PYR/PP interface [polypeptide binding]; other site 639283008733 dimer interface [polypeptide binding]; other site 639283008734 TPP binding site [chemical binding]; other site 639283008735 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 639283008736 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 639283008737 TPP-binding site; other site 639283008738 dimer interface [polypeptide binding]; other site 639283008739 formyl-coenzyme A transferase; Provisional; Region: PRK05398 639283008740 CoA-transferase family III; Region: CoA_transf_3; pfam02515 639283008741 formyl-coenzyme A transferase; Provisional; Region: PRK05398 639283008742 CoA-transferase family III; Region: CoA_transf_3; pfam02515 639283008743 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 639283008744 Transcriptional regulator [Transcription]; Region: IclR; COG1414 639283008745 Bacterial transcriptional regulator; Region: IclR; pfam01614 639283008746 glyoxylate carboligase; Provisional; Region: PRK11269 639283008747 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 639283008748 PYR/PP interface [polypeptide binding]; other site 639283008749 dimer interface [polypeptide binding]; other site 639283008750 TPP binding site [chemical binding]; other site 639283008751 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 639283008752 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 639283008753 TPP-binding site [chemical binding]; other site 639283008754 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 639283008755 tartronate semialdehyde reductase; Provisional; Region: PRK15059 639283008756 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 639283008757 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 639283008758 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 639283008759 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 639283008760 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 639283008761 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 639283008762 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 639283008763 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 639283008764 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 639283008765 CoA-ligase; Region: Ligase_CoA; pfam00549 639283008766 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 639283008767 CoA binding domain; Region: CoA_binding; smart00881 639283008768 CoA-ligase; Region: Ligase_CoA; pfam00549 639283008769 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 639283008770 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 639283008771 GDP-binding site [chemical binding]; other site 639283008772 ACT binding site; other site 639283008773 IMP binding site; other site 639283008774 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 639283008775 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 639283008776 putative metal binding site [ion binding]; other site 639283008777 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 639283008778 active site 639283008779 EamA-like transporter family; Region: EamA; pfam00892 639283008780 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 639283008781 EamA-like transporter family; Region: EamA; pfam00892 639283008782 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 639283008783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283008784 Coenzyme A binding pocket [chemical binding]; other site 639283008785 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 639283008786 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 639283008787 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 639283008788 active site 639283008789 catalytic site [active] 639283008790 tetramer interface [polypeptide binding]; other site 639283008791 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 639283008792 active site 639283008793 intersubunit interface [polypeptide binding]; other site 639283008794 catalytic residue [active] 639283008795 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 639283008796 classical (c) SDRs; Region: SDR_c; cd05233 639283008797 NAD(P) binding site [chemical binding]; other site 639283008798 active site 639283008799 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 639283008800 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 639283008801 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 639283008802 ligand binding site [chemical binding]; other site 639283008803 NAD binding site [chemical binding]; other site 639283008804 dimerization interface [polypeptide binding]; other site 639283008805 catalytic site [active] 639283008806 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 639283008807 putative L-serine binding site [chemical binding]; other site 639283008808 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 639283008809 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283008810 catalytic residue [active] 639283008811 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 639283008812 Protein of unknown function (DUF533); Region: DUF533; pfam04391 639283008813 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 639283008814 putative metal binding site [ion binding]; other site 639283008815 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 639283008816 hydroxyglutarate oxidase; Provisional; Region: PRK11728 639283008817 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 639283008818 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 639283008819 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 639283008820 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 639283008821 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 639283008822 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 639283008823 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 639283008824 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 639283008825 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 639283008826 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 639283008827 conserved cys residue [active] 639283008828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283008829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283008830 Predicted membrane protein [Function unknown]; Region: COG2510 639283008831 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 639283008832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283008833 non-specific DNA binding site [nucleotide binding]; other site 639283008834 salt bridge; other site 639283008835 sequence-specific DNA binding site [nucleotide binding]; other site 639283008836 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 639283008837 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 639283008838 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 639283008839 [2Fe-2S] cluster binding site [ion binding]; other site 639283008840 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 639283008841 putative alpha subunit interface [polypeptide binding]; other site 639283008842 putative active site [active] 639283008843 putative substrate binding site [chemical binding]; other site 639283008844 Fe binding site [ion binding]; other site 639283008845 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 639283008846 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 639283008847 FAD binding pocket [chemical binding]; other site 639283008848 FAD binding motif [chemical binding]; other site 639283008849 phosphate binding motif [ion binding]; other site 639283008850 beta-alpha-beta structure motif; other site 639283008851 NAD binding pocket [chemical binding]; other site 639283008852 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283008853 catalytic loop [active] 639283008854 iron binding site [ion binding]; other site 639283008855 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 639283008856 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 639283008857 conserved cys residue [active] 639283008858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283008859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283008860 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 639283008861 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 639283008862 Sulfate transporter family; Region: Sulfate_transp; pfam00916 639283008863 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 639283008864 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 639283008865 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 639283008866 putative active site [active] 639283008867 putative FMN binding site [chemical binding]; other site 639283008868 putative substrate binding site [chemical binding]; other site 639283008869 putative catalytic residue [active] 639283008870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 639283008871 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 639283008872 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 639283008873 Cysteine-rich domain; Region: CCG; pfam02754 639283008874 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 639283008875 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 639283008876 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 639283008877 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 639283008878 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 639283008879 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 639283008880 active site 639283008881 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 639283008882 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 639283008883 Ligand binding site; other site 639283008884 Putative Catalytic site; other site 639283008885 DXD motif; other site 639283008886 choline dehydrogenase; Validated; Region: PRK02106 639283008887 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 639283008888 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 639283008889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283008890 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 639283008891 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 639283008892 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 639283008893 NAD(P) binding site [chemical binding]; other site 639283008894 catalytic residues [active] 639283008895 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 639283008896 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 639283008897 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283008898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283008899 dimer interface [polypeptide binding]; other site 639283008900 conserved gate region; other site 639283008901 putative PBP binding loops; other site 639283008902 ABC-ATPase subunit interface; other site 639283008903 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 639283008904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283008905 Walker A/P-loop; other site 639283008906 ATP binding site [chemical binding]; other site 639283008907 Q-loop/lid; other site 639283008908 ABC transporter signature motif; other site 639283008909 Walker B; other site 639283008910 D-loop; other site 639283008911 H-loop/switch region; other site 639283008912 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 639283008913 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 639283008914 active site 639283008915 substrate binding site [chemical binding]; other site 639283008916 metal binding site [ion binding]; metal-binding site 639283008917 FtsH Extracellular; Region: FtsH_ext; pfam06480 639283008918 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 639283008919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283008920 Walker A motif; other site 639283008921 ATP binding site [chemical binding]; other site 639283008922 Walker B motif; other site 639283008923 arginine finger; other site 639283008924 Peptidase family M41; Region: Peptidase_M41; pfam01434 639283008925 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 639283008926 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 639283008927 Ligand Binding Site [chemical binding]; other site 639283008928 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 639283008929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283008930 binding surface 639283008931 TPR motif; other site 639283008932 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 639283008933 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 639283008934 ligand binding site [chemical binding]; other site 639283008935 translocation protein TolB; Provisional; Region: tolB; PRK05137 639283008936 TolB amino-terminal domain; Region: TolB_N; pfam04052 639283008937 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 639283008938 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 639283008939 Gram-negative bacterial tonB protein; Region: TonB; cl10048 639283008940 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 639283008941 TolR protein; Region: tolR; TIGR02801 639283008942 TolQ protein; Region: tolQ; TIGR02796 639283008943 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 639283008944 active site 639283008945 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 639283008946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283008947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283008948 WHG domain; Region: WHG; pfam13305 639283008949 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 639283008950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283008951 Walker A motif; other site 639283008952 ATP binding site [chemical binding]; other site 639283008953 Walker B motif; other site 639283008954 arginine finger; other site 639283008955 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 639283008956 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 639283008957 RuvA N terminal domain; Region: RuvA_N; pfam01330 639283008958 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 639283008959 active site 639283008960 putative DNA-binding cleft [nucleotide binding]; other site 639283008961 dimer interface [polypeptide binding]; other site 639283008962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283008963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283008964 active site 639283008965 catalytic tetrad [active] 639283008966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283008967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283008968 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 639283008969 putative effector binding pocket; other site 639283008970 putative dimerization interface [polypeptide binding]; other site 639283008971 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 639283008972 EamA-like transporter family; Region: EamA; pfam00892 639283008973 hypothetical protein; Validated; Region: PRK07668 639283008974 hypothetical protein; Validated; Region: PRK00110 639283008975 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 639283008976 putative active site [active] 639283008977 metal binding site [ion binding]; metal-binding site 639283008978 homodimer binding site [polypeptide binding]; other site 639283008979 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 639283008980 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 639283008981 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 639283008982 NAD(P) binding site [chemical binding]; other site 639283008983 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 639283008984 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 639283008985 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 639283008986 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 639283008987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283008988 Walker A/P-loop; other site 639283008989 ATP binding site [chemical binding]; other site 639283008990 Q-loop/lid; other site 639283008991 ABC transporter signature motif; other site 639283008992 Walker B; other site 639283008993 D-loop; other site 639283008994 H-loop/switch region; other site 639283008995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 639283008996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283008997 Coenzyme A binding pocket [chemical binding]; other site 639283008998 hypothetical protein; Validated; Region: PRK09039 639283008999 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 639283009000 ligand binding site [chemical binding]; other site 639283009001 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 639283009002 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 639283009003 active site 639283009004 dimerization interface [polypeptide binding]; other site 639283009005 Cell division protein ZapA; Region: ZapA; pfam05164 639283009006 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 639283009007 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 639283009008 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 639283009009 TPP-binding site [chemical binding]; other site 639283009010 dimer interface [polypeptide binding]; other site 639283009011 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 639283009012 PYR/PP interface [polypeptide binding]; other site 639283009013 dimer interface [polypeptide binding]; other site 639283009014 TPP binding site [chemical binding]; other site 639283009015 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 639283009016 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 639283009017 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 639283009018 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 639283009019 Phosphoglycerate kinase; Region: PGK; pfam00162 639283009020 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 639283009021 substrate binding site [chemical binding]; other site 639283009022 hinge regions; other site 639283009023 ADP binding site [chemical binding]; other site 639283009024 catalytic site [active] 639283009025 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 639283009026 active site 639283009027 intersubunit interface [polypeptide binding]; other site 639283009028 catalytic residue [active] 639283009029 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 639283009030 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 639283009031 Walker A/P-loop; other site 639283009032 ATP binding site [chemical binding]; other site 639283009033 Q-loop/lid; other site 639283009034 ABC transporter signature motif; other site 639283009035 Walker B; other site 639283009036 D-loop; other site 639283009037 H-loop/switch region; other site 639283009038 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 639283009039 active site 639283009040 thiamine phosphate binding site [chemical binding]; other site 639283009041 pyrophosphate binding site [ion binding]; other site 639283009042 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 639283009043 Sel1-like repeats; Region: SEL1; smart00671 639283009044 Sel1-like repeats; Region: SEL1; smart00671 639283009045 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 639283009046 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 639283009047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283009048 PAS fold; Region: PAS_3; pfam08447 639283009049 putative active site [active] 639283009050 heme pocket [chemical binding]; other site 639283009051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283009052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283009053 metal binding site [ion binding]; metal-binding site 639283009054 active site 639283009055 I-site; other site 639283009056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283009057 hypothetical protein; Validated; Region: PRK00228 639283009058 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 639283009059 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 639283009060 catalytic triad [active] 639283009061 dimer interface [polypeptide binding]; other site 639283009062 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 639283009063 Uncharacterized small protein [Function unknown]; Region: COG5570 639283009064 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 639283009065 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 639283009066 acyl-activating enzyme (AAE) consensus motif; other site 639283009067 putative AMP binding site [chemical binding]; other site 639283009068 putative active site [active] 639283009069 putative CoA binding site [chemical binding]; other site 639283009070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 639283009071 Uncharacterized conserved protein [Function unknown]; Region: COG2353 639283009072 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 639283009073 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 639283009074 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 639283009075 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 639283009076 putative active site [active] 639283009077 putative substrate binding site [chemical binding]; other site 639283009078 ATP binding site [chemical binding]; other site 639283009079 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 639283009080 RNA/DNA hybrid binding site [nucleotide binding]; other site 639283009081 active site 639283009082 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 639283009083 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 639283009084 TPR repeat; Region: TPR_11; pfam13414 639283009085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283009086 binding surface 639283009087 TPR motif; other site 639283009088 TPR repeat; Region: TPR_11; pfam13414 639283009089 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 639283009090 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 639283009091 folate binding site [chemical binding]; other site 639283009092 NADP+ binding site [chemical binding]; other site 639283009093 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 639283009094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 639283009095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 639283009096 thymidylate synthase; Reviewed; Region: thyA; PRK01827 639283009097 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 639283009098 dimerization interface [polypeptide binding]; other site 639283009099 active site 639283009100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 639283009101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283009102 Coenzyme A binding pocket [chemical binding]; other site 639283009103 fumarate hydratase; Reviewed; Region: fumC; PRK00485 639283009104 Class II fumarases; Region: Fumarase_classII; cd01362 639283009105 active site 639283009106 tetramer interface [polypeptide binding]; other site 639283009107 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 639283009108 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 639283009109 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 639283009110 HflK protein; Region: hflK; TIGR01933 639283009111 HflC protein; Region: hflC; TIGR01932 639283009112 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 639283009113 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 639283009114 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 639283009115 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 639283009116 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 639283009117 protein binding site [polypeptide binding]; other site 639283009118 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 639283009119 protein binding site [polypeptide binding]; other site 639283009120 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 639283009121 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 639283009122 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 639283009123 MOFRL family; Region: MOFRL; pfam05161 639283009124 N-formylglutamate amidohydrolase; Region: FGase; cl01522 639283009125 Protein of unknown function (DUF1244); Region: DUF1244; pfam06844 639283009126 hypothetical protein; Provisional; Region: PRK13694 639283009127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 639283009128 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 639283009129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 639283009130 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283009131 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283009132 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283009133 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 639283009134 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 639283009135 ATP-grasp domain; Region: ATP-grasp; pfam02222 639283009136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 639283009137 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 639283009138 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 639283009139 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 639283009140 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 639283009141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283009142 motif II; other site 639283009143 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 639283009144 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 639283009145 FAD binding domain; Region: FAD_binding_4; pfam01565 639283009146 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 639283009147 active site 639283009148 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 639283009149 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 639283009150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283009151 S-adenosylmethionine binding site [chemical binding]; other site 639283009152 Domain of unknown function DUF29; Region: DUF29; pfam01724 639283009153 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 639283009154 Part of AAA domain; Region: AAA_19; pfam13245 639283009155 Family description; Region: UvrD_C_2; pfam13538 639283009156 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283009157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283009158 substrate binding pocket [chemical binding]; other site 639283009159 membrane-bound complex binding site; other site 639283009160 hinge residues; other site 639283009161 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 639283009162 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 639283009163 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 639283009164 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 639283009165 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 639283009166 active site 639283009167 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 639283009168 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 639283009169 DNA binding residues [nucleotide binding] 639283009170 dimer interface [polypeptide binding]; other site 639283009171 short chain dehydrogenase; Validated; Region: PRK06182 639283009172 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 639283009173 NADP binding site [chemical binding]; other site 639283009174 active site 639283009175 steroid binding site; other site 639283009176 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 639283009177 Isochorismatase family; Region: Isochorismatase; pfam00857 639283009178 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 639283009179 catalytic triad [active] 639283009180 conserved cis-peptide bond; other site 639283009181 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 639283009182 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 639283009183 nucleotide binding pocket [chemical binding]; other site 639283009184 K-X-D-G motif; other site 639283009185 catalytic site [active] 639283009186 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 639283009187 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 639283009188 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 639283009189 Dimer interface [polypeptide binding]; other site 639283009190 BRCT sequence motif; other site 639283009191 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 639283009192 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 639283009193 Walker A/P-loop; other site 639283009194 ATP binding site [chemical binding]; other site 639283009195 Q-loop/lid; other site 639283009196 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 639283009197 ABC transporter signature motif; other site 639283009198 Walker B; other site 639283009199 D-loop; other site 639283009200 H-loop/switch region; other site 639283009201 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 639283009202 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 639283009203 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 639283009204 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 639283009205 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 639283009206 nucleotide binding site [chemical binding]; other site 639283009207 SulA interaction site; other site 639283009208 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 639283009209 Cell division protein FtsA; Region: FtsA; smart00842 639283009210 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 639283009211 Cell division protein FtsA; Region: FtsA; pfam14450 639283009212 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 639283009213 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 639283009214 Cell division protein FtsQ; Region: FtsQ; pfam03799 639283009215 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 639283009216 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 639283009217 ATP-grasp domain; Region: ATP-grasp_4; cl17255 639283009218 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 639283009219 FAD binding domain; Region: FAD_binding_4; pfam01565 639283009220 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 639283009221 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 639283009222 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 639283009223 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 639283009224 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 639283009225 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 639283009226 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 639283009227 active site 639283009228 homodimer interface [polypeptide binding]; other site 639283009229 cell division protein FtsW; Region: ftsW; TIGR02614 639283009230 ethanolamine permease; Region: 2A0305; TIGR00908 639283009231 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 639283009232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283009233 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 639283009234 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 639283009235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 639283009236 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 639283009237 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 639283009238 Mg++ binding site [ion binding]; other site 639283009239 putative catalytic motif [active] 639283009240 putative substrate binding site [chemical binding]; other site 639283009241 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 639283009242 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 639283009243 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 639283009244 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 639283009245 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 639283009246 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 639283009247 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 639283009248 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 639283009249 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 639283009250 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 639283009251 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 639283009252 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 639283009253 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 639283009254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283009255 S-adenosylmethionine binding site [chemical binding]; other site 639283009256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 639283009257 cell division protein MraZ; Reviewed; Region: PRK00326 639283009258 MraZ protein; Region: MraZ; pfam02381 639283009259 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 639283009260 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 639283009261 amidase catalytic site [active] 639283009262 Zn binding residues [ion binding]; other site 639283009263 substrate binding site [chemical binding]; other site 639283009264 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283009265 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 639283009266 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 639283009267 N-acetyl-D-glucosamine binding site [chemical binding]; other site 639283009268 catalytic residue [active] 639283009269 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 639283009270 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 639283009271 dihydrodipicolinate reductase; Provisional; Region: PRK00048 639283009272 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 639283009273 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 639283009274 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 639283009275 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 639283009276 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 639283009277 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 639283009278 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 639283009279 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 639283009280 ligand binding site [chemical binding]; other site 639283009281 homodimer interface [polypeptide binding]; other site 639283009282 NAD(P) binding site [chemical binding]; other site 639283009283 trimer interface B [polypeptide binding]; other site 639283009284 trimer interface A [polypeptide binding]; other site 639283009285 pyruvate carboxylase; Reviewed; Region: PRK12999 639283009286 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 639283009287 ATP-grasp domain; Region: ATP-grasp_4; cl17255 639283009288 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 639283009289 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 639283009290 active site 639283009291 catalytic residues [active] 639283009292 metal binding site [ion binding]; metal-binding site 639283009293 homodimer binding site [polypeptide binding]; other site 639283009294 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 639283009295 carboxyltransferase (CT) interaction site; other site 639283009296 biotinylation site [posttranslational modification]; other site 639283009297 pyruvate kinase; Provisional; Region: PRK06247 639283009298 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 639283009299 domain interfaces; other site 639283009300 active site 639283009301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283009302 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283009303 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 639283009304 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 639283009305 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 639283009306 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 639283009307 DXD motif; other site 639283009308 PilZ domain; Region: PilZ; pfam07238 639283009309 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 639283009310 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 639283009311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283009312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283009313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283009314 dimerization interface [polypeptide binding]; other site 639283009315 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 639283009316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283009317 putative substrate translocation pore; other site 639283009318 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283009319 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283009320 active site 639283009321 catalytic tetrad [active] 639283009322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283009323 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283009324 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 639283009325 ligand binding site [chemical binding]; other site 639283009326 regulator interaction site; other site 639283009327 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 639283009328 ANTAR domain; Region: ANTAR; pfam03861 639283009329 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 639283009330 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 639283009331 multimer interface [polypeptide binding]; other site 639283009332 active site 639283009333 catalytic triad [active] 639283009334 dimer interface [polypeptide binding]; other site 639283009335 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 639283009336 metal ion-dependent adhesion site (MIDAS); other site 639283009337 MoxR-like ATPases [General function prediction only]; Region: COG0714 639283009338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283009339 Walker A motif; other site 639283009340 ATP binding site [chemical binding]; other site 639283009341 Walker B motif; other site 639283009342 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 639283009343 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 639283009344 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 639283009345 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 639283009346 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 639283009347 Walker A/P-loop; other site 639283009348 ATP binding site [chemical binding]; other site 639283009349 Q-loop/lid; other site 639283009350 ABC transporter signature motif; other site 639283009351 Walker B; other site 639283009352 D-loop; other site 639283009353 H-loop/switch region; other site 639283009354 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 639283009355 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 639283009356 Walker A/P-loop; other site 639283009357 ATP binding site [chemical binding]; other site 639283009358 Q-loop/lid; other site 639283009359 ABC transporter signature motif; other site 639283009360 Walker B; other site 639283009361 D-loop; other site 639283009362 H-loop/switch region; other site 639283009363 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 639283009364 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 639283009365 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283009366 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283009367 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283009368 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 639283009369 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 639283009370 putative NAD(P) binding site [chemical binding]; other site 639283009371 putative substrate binding site [chemical binding]; other site 639283009372 catalytic Zn binding site [ion binding]; other site 639283009373 structural Zn binding site [ion binding]; other site 639283009374 putative phosphoketolase; Provisional; Region: PRK05261 639283009375 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 639283009376 TPP-binding site; other site 639283009377 Src Homology 3 domain superfamily; Region: SH3; cl17036 639283009378 peptide ligand binding site [polypeptide binding]; other site 639283009379 XFP C-terminal domain; Region: XFP_C; pfam09363 639283009380 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 639283009381 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 639283009382 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283009383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283009384 active site 639283009385 phosphorylation site [posttranslational modification] 639283009386 intermolecular recognition site; other site 639283009387 dimerization interface [polypeptide binding]; other site 639283009388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283009389 DNA binding site [nucleotide binding] 639283009390 sensor protein BasS/PmrB; Provisional; Region: PRK10755 639283009391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283009392 dimer interface [polypeptide binding]; other site 639283009393 phosphorylation site [posttranslational modification] 639283009394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283009395 ATP binding site [chemical binding]; other site 639283009396 Mg2+ binding site [ion binding]; other site 639283009397 G-X-G motif; other site 639283009398 Protein of unknown function DUF72; Region: DUF72; pfam01904 639283009399 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 639283009400 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 639283009401 conserved cys residue [active] 639283009402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283009403 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283009404 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 639283009405 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283009406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283009407 Walker A/P-loop; other site 639283009408 ATP binding site [chemical binding]; other site 639283009409 Q-loop/lid; other site 639283009410 ABC transporter signature motif; other site 639283009411 Walker B; other site 639283009412 D-loop; other site 639283009413 H-loop/switch region; other site 639283009414 TOBE domain; Region: TOBE_2; pfam08402 639283009415 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 639283009416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283009417 dimer interface [polypeptide binding]; other site 639283009418 conserved gate region; other site 639283009419 putative PBP binding loops; other site 639283009420 ABC-ATPase subunit interface; other site 639283009421 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283009422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283009423 dimer interface [polypeptide binding]; other site 639283009424 conserved gate region; other site 639283009425 putative PBP binding loops; other site 639283009426 ABC-ATPase subunit interface; other site 639283009427 proline racemase; Provisional; Region: PRK13969 639283009428 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 639283009429 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 639283009430 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 639283009431 tetramer interface [polypeptide binding]; other site 639283009432 active site 639283009433 Mg2+/Mn2+ binding site [ion binding]; other site 639283009434 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 639283009435 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283009436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283009437 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283009438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283009439 DNA-binding site [nucleotide binding]; DNA binding site 639283009440 FCD domain; Region: FCD; pfam07729 639283009441 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 639283009442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283009443 putative DNA binding site [nucleotide binding]; other site 639283009444 putative Zn2+ binding site [ion binding]; other site 639283009445 AsnC family; Region: AsnC_trans_reg; pfam01037 639283009446 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 639283009447 TPP-binding site [chemical binding]; other site 639283009448 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 639283009449 PYR/PP interface [polypeptide binding]; other site 639283009450 dimer interface [polypeptide binding]; other site 639283009451 TPP binding site [chemical binding]; other site 639283009452 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 639283009453 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 639283009454 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 639283009455 putative NAD(P) binding site [chemical binding]; other site 639283009456 active site 639283009457 putative substrate binding site [chemical binding]; other site 639283009458 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 639283009459 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 639283009460 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 639283009461 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 639283009462 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 639283009463 putative glycosyl transferase; Provisional; Region: PRK10307 639283009464 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 639283009465 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 639283009466 active site 639283009467 homodimer interface [polypeptide binding]; other site 639283009468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283009469 NAD(P) binding site [chemical binding]; other site 639283009470 active site 639283009471 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 639283009472 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 639283009473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283009474 NAD(P) binding site [chemical binding]; other site 639283009475 active site 639283009476 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 639283009477 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283009478 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 639283009479 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 639283009480 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283009481 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 639283009482 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 639283009483 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 639283009484 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 639283009485 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 639283009486 NAD(P) binding site [chemical binding]; other site 639283009487 homodimer interface [polypeptide binding]; other site 639283009488 substrate binding site [chemical binding]; other site 639283009489 active site 639283009490 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 639283009491 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 639283009492 inhibitor-cofactor binding pocket; inhibition site 639283009493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283009494 catalytic residue [active] 639283009495 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 639283009496 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 639283009497 putative trimer interface [polypeptide binding]; other site 639283009498 putative CoA binding site [chemical binding]; other site 639283009499 Bacterial sugar transferase; Region: Bac_transf; pfam02397 639283009500 PHP domain; Region: PHP; pfam02811 639283009501 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 639283009502 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 639283009503 SLBB domain; Region: SLBB; pfam10531 639283009504 chain length determinant protein EpsF; Region: EpsF; TIGR03017 639283009505 Chain length determinant protein; Region: Wzz; pfam02706 639283009506 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 639283009507 Chain length determinant protein; Region: Wzz; cl15801 639283009508 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 639283009509 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 639283009510 Magnesium ion binding site [ion binding]; other site 639283009511 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 639283009512 HSP70 interaction site [polypeptide binding]; other site 639283009513 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 639283009514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283009515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283009516 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 639283009517 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283009518 ligand binding site [chemical binding]; other site 639283009519 regulator interaction site; other site 639283009520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 639283009521 active site 639283009522 phosphorylation site [posttranslational modification] 639283009523 intermolecular recognition site; other site 639283009524 dimerization interface [polypeptide binding]; other site 639283009525 ANTAR domain; Region: ANTAR; pfam03861 639283009526 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283009527 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 639283009528 putative ligand binding site [chemical binding]; other site 639283009529 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283009530 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283009531 TM-ABC transporter signature motif; other site 639283009532 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283009533 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283009534 TM-ABC transporter signature motif; other site 639283009535 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 639283009536 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283009537 Walker A/P-loop; other site 639283009538 ATP binding site [chemical binding]; other site 639283009539 Q-loop/lid; other site 639283009540 ABC transporter signature motif; other site 639283009541 Walker B; other site 639283009542 D-loop; other site 639283009543 H-loop/switch region; other site 639283009544 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283009545 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283009546 Walker A/P-loop; other site 639283009547 ATP binding site [chemical binding]; other site 639283009548 Q-loop/lid; other site 639283009549 ABC transporter signature motif; other site 639283009550 Walker B; other site 639283009551 D-loop; other site 639283009552 H-loop/switch region; other site 639283009553 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 639283009554 Transcriptional regulators [Transcription]; Region: MarR; COG1846 639283009555 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 639283009556 Fusaric acid resistance protein family; Region: FUSC; pfam04632 639283009557 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 639283009558 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 639283009559 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 639283009560 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283009561 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283009562 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 639283009563 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 639283009564 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 639283009565 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283009566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283009567 DNA-binding site [nucleotide binding]; DNA binding site 639283009568 FCD domain; Region: FCD; pfam07729 639283009569 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 639283009570 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283009571 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283009572 Walker A/P-loop; other site 639283009573 ATP binding site [chemical binding]; other site 639283009574 Q-loop/lid; other site 639283009575 ABC transporter signature motif; other site 639283009576 Walker B; other site 639283009577 D-loop; other site 639283009578 H-loop/switch region; other site 639283009579 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283009580 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283009581 TM-ABC transporter signature motif; other site 639283009582 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283009583 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283009584 Walker A/P-loop; other site 639283009585 ATP binding site [chemical binding]; other site 639283009586 Q-loop/lid; other site 639283009587 ABC transporter signature motif; other site 639283009588 Walker B; other site 639283009589 D-loop; other site 639283009590 H-loop/switch region; other site 639283009591 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283009592 TM-ABC transporter signature motif; other site 639283009593 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283009594 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 639283009595 putative ligand binding site [chemical binding]; other site 639283009596 Predicted amidohydrolase [General function prediction only]; Region: COG0388 639283009597 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 639283009598 putative active site [active] 639283009599 catalytic triad [active] 639283009600 putative dimer interface [polypeptide binding]; other site 639283009601 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 639283009602 ANTAR domain; Region: ANTAR; pfam03861 639283009603 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283009604 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 639283009605 ligand binding site [chemical binding]; other site 639283009606 regulator interaction site; other site 639283009607 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 639283009608 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 639283009609 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 639283009610 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 639283009611 homodimer interface [polypeptide binding]; other site 639283009612 active site 639283009613 TDP-binding site; other site 639283009614 acceptor substrate-binding pocket; other site 639283009615 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 639283009616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283009617 NAD(P) binding site [chemical binding]; other site 639283009618 active site 639283009619 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 639283009620 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 639283009621 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 639283009622 NADP binding site [chemical binding]; other site 639283009623 homodimer interface [polypeptide binding]; other site 639283009624 active site 639283009625 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 639283009626 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283009627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283009628 DNA-binding site [nucleotide binding]; DNA binding site 639283009629 FCD domain; Region: FCD; pfam07729 639283009630 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 639283009631 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 639283009632 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 639283009633 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 639283009634 DctM-like transporters; Region: DctM; pfam06808 639283009635 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 639283009636 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 639283009637 RNA polymerase sigma factor; Provisional; Region: PRK11924 639283009638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283009639 K+-transporting ATPase, c chain; Region: KdpC; cl00944 639283009640 sulfite:cytochrome c oxidoreductase subunit A (SorA), molybdopterin binding domain. SorA is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SorB, a small c-type heme containing subunit, it forms a hetrodimer. It; Region: bact_SorA_Moco; cd02114 639283009641 sulfite oxidase; Provisional; Region: PLN00177 639283009642 Moco binding site; other site 639283009643 metal coordination site [ion binding]; other site 639283009644 putative dimerization interface [polypeptide binding]; other site 639283009645 Cytochrome c; Region: Cytochrom_C; cl11414 639283009646 CHAD domain; Region: CHAD; pfam05235 639283009647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283009648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283009649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 639283009650 dimerization interface [polypeptide binding]; other site 639283009651 formate dehydrogenase; Provisional; Region: PRK07574 639283009652 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 639283009653 dimerization interface [polypeptide binding]; other site 639283009654 ligand binding site [chemical binding]; other site 639283009655 NAD binding site [chemical binding]; other site 639283009656 catalytic site [active] 639283009657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283009658 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 639283009659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 639283009660 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 639283009661 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 639283009662 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 639283009663 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 639283009664 Protein of unknown function (DUF429); Region: DUF429; cl12046 639283009665 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 639283009666 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 639283009667 CysD dimerization site [polypeptide binding]; other site 639283009668 G1 box; other site 639283009669 putative GEF interaction site [polypeptide binding]; other site 639283009670 GTP/Mg2+ binding site [chemical binding]; other site 639283009671 Switch I region; other site 639283009672 G2 box; other site 639283009673 G3 box; other site 639283009674 Switch II region; other site 639283009675 G4 box; other site 639283009676 G5 box; other site 639283009677 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 639283009678 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 639283009679 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 639283009680 ligand-binding site [chemical binding]; other site 639283009681 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 639283009682 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 639283009683 Active Sites [active] 639283009684 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 639283009685 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 639283009686 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 639283009687 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 639283009688 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 639283009689 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 639283009690 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 639283009691 Active Sites [active] 639283009692 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 639283009693 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 639283009694 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 639283009695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283009696 dimer interface [polypeptide binding]; other site 639283009697 conserved gate region; other site 639283009698 putative PBP binding loops; other site 639283009699 ABC-ATPase subunit interface; other site 639283009700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283009701 dimer interface [polypeptide binding]; other site 639283009702 conserved gate region; other site 639283009703 putative PBP binding loops; other site 639283009704 ABC-ATPase subunit interface; other site 639283009705 Predicted membrane protein [Function unknown]; Region: COG1238 639283009706 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 639283009707 metal binding site [ion binding]; metal-binding site 639283009708 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 639283009709 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 639283009710 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 639283009711 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 639283009712 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 639283009713 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 639283009714 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 639283009715 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 639283009716 Mechanosensitive ion channel; Region: MS_channel; pfam00924 639283009717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283009718 Coenzyme A binding pocket [chemical binding]; other site 639283009719 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 639283009720 Predicted ATPase [General function prediction only]; Region: COG1485 639283009721 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 639283009722 malate dehydrogenase; Reviewed; Region: PRK06223 639283009723 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 639283009724 NAD(P) binding site [chemical binding]; other site 639283009725 dimer interface [polypeptide binding]; other site 639283009726 tetramer (dimer of dimers) interface [polypeptide binding]; other site 639283009727 substrate binding site [chemical binding]; other site 639283009728 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 639283009729 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 639283009730 TPP-binding site [chemical binding]; other site 639283009731 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 639283009732 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 639283009733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 639283009734 E3 interaction surface; other site 639283009735 lipoyl attachment site [posttranslational modification]; other site 639283009736 e3 binding domain; Region: E3_binding; pfam02817 639283009737 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 639283009738 L-lactate permease; Region: Lactate_perm; cl00701 639283009739 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 639283009740 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 639283009741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 639283009742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283009743 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 639283009744 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 639283009745 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283009746 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 639283009747 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 639283009748 active site 639283009749 DNA binding site [nucleotide binding] 639283009750 Int/Topo IB signature motif; other site 639283009751 primosome assembly protein PriA; Validated; Region: PRK05580 639283009752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 639283009753 ATP binding site [chemical binding]; other site 639283009754 putative Mg++ binding site [ion binding]; other site 639283009755 helicase superfamily c-terminal domain; Region: HELICc; smart00490 639283009756 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 639283009757 Predicted permeases [General function prediction only]; Region: COG0679 639283009758 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 639283009759 putative active site [active] 639283009760 catalytic site [active] 639283009761 putative metal binding site [ion binding]; other site 639283009762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 639283009763 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 639283009764 active site 639283009765 HIGH motif; other site 639283009766 nucleotide binding site [chemical binding]; other site 639283009767 active site 639283009768 KMSKS motif; other site 639283009769 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 639283009770 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 639283009771 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 639283009772 L-aspartate oxidase; Provisional; Region: PRK06175 639283009773 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 639283009774 succinate dehydrogenase, hydrophobic membrane anchor protein; Region: succ_dehyd_anc; TIGR02968 639283009775 Iron-sulfur protein interface; other site 639283009776 proximal heme binding site [chemical binding]; other site 639283009777 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 639283009778 Iron-sulfur protein interface; other site 639283009779 proximal quinone binding site [chemical binding]; other site 639283009780 SdhD (CybS) interface [polypeptide binding]; other site 639283009781 proximal heme binding site [chemical binding]; other site 639283009782 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 639283009783 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 639283009784 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 639283009785 Peptidase family M23; Region: Peptidase_M23; pfam01551 639283009786 Predicted esterase [General function prediction only]; Region: COG0400 639283009787 putative hydrolase; Provisional; Region: PRK11460 639283009788 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 639283009789 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 639283009790 active site 639283009791 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 639283009792 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 639283009793 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 639283009794 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 639283009795 dimer interface [polypeptide binding]; other site 639283009796 putative PBP binding regions; other site 639283009797 ABC-ATPase subunit interface; other site 639283009798 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 639283009799 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 639283009800 Walker A/P-loop; other site 639283009801 ATP binding site [chemical binding]; other site 639283009802 Q-loop/lid; other site 639283009803 ABC transporter signature motif; other site 639283009804 Walker B; other site 639283009805 D-loop; other site 639283009806 H-loop/switch region; other site 639283009807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283009808 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 639283009809 NAD(P) binding site [chemical binding]; other site 639283009810 active site 639283009811 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 639283009812 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 639283009813 acyl-activating enzyme (AAE) consensus motif; other site 639283009814 AMP binding site [chemical binding]; other site 639283009815 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 639283009816 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 639283009817 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 639283009818 Isochorismatase family; Region: Isochorismatase; pfam00857 639283009819 catalytic triad [active] 639283009820 conserved cis-peptide bond; other site 639283009821 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 639283009822 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 639283009823 acyl-activating enzyme (AAE) consensus motif; other site 639283009824 active site 639283009825 AMP binding site [chemical binding]; other site 639283009826 substrate binding site [chemical binding]; other site 639283009827 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 639283009828 Uncharacterized conserved protein [Function unknown]; Region: COG3391 639283009829 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283009830 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283009831 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 639283009832 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 639283009833 intersubunit interface [polypeptide binding]; other site 639283009834 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 639283009835 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 639283009836 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 639283009837 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 639283009838 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 639283009839 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 639283009840 YGGT family; Region: YGGT; pfam02325 639283009841 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 639283009842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283009843 Coenzyme A binding pocket [chemical binding]; other site 639283009844 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 639283009845 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 639283009846 G1 box; other site 639283009847 putative GEF interaction site [polypeptide binding]; other site 639283009848 GTP/Mg2+ binding site [chemical binding]; other site 639283009849 Switch I region; other site 639283009850 G2 box; other site 639283009851 G3 box; other site 639283009852 Switch II region; other site 639283009853 G4 box; other site 639283009854 G5 box; other site 639283009855 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 639283009856 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 639283009857 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 639283009858 Peptidase family M50; Region: Peptidase_M50; pfam02163 639283009859 active site 639283009860 putative substrate binding region [chemical binding]; other site 639283009861 FOG: CBS domain [General function prediction only]; Region: COG0517 639283009862 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 639283009863 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 639283009864 argininosuccinate synthase; Provisional; Region: PRK13820 639283009865 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 639283009866 ANP binding site [chemical binding]; other site 639283009867 Substrate Binding Site II [chemical binding]; other site 639283009868 Substrate Binding Site I [chemical binding]; other site 639283009869 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 639283009870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283009871 FeS/SAM binding site; other site 639283009872 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 639283009873 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 639283009874 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 639283009875 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 639283009876 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 639283009877 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 639283009878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283009879 FeS/SAM binding site; other site 639283009880 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 639283009881 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 639283009882 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 639283009883 P loop; other site 639283009884 GTP binding site [chemical binding]; other site 639283009885 intracellular septation protein A; Reviewed; Region: PRK00259 639283009886 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283009887 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283009888 active site 639283009889 catalytic tetrad [active] 639283009890 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 639283009891 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 639283009892 active site 639283009893 catalytic triad [active] 639283009894 oxyanion hole [active] 639283009895 switch loop; other site 639283009896 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 639283009897 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 639283009898 Walker A/P-loop; other site 639283009899 ATP binding site [chemical binding]; other site 639283009900 Q-loop/lid; other site 639283009901 ABC transporter signature motif; other site 639283009902 Walker B; other site 639283009903 D-loop; other site 639283009904 H-loop/switch region; other site 639283009905 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 639283009906 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 639283009907 FtsX-like permease family; Region: FtsX; pfam02687 639283009908 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 639283009909 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 639283009910 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 639283009911 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283009912 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 639283009913 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 639283009914 dimer interface [polypeptide binding]; other site 639283009915 succinic semialdehyde dehydrogenase; Region: PLN02278 639283009916 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 639283009917 tetramerization interface [polypeptide binding]; other site 639283009918 NAD(P) binding site [chemical binding]; other site 639283009919 catalytic residues [active] 639283009920 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 639283009921 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283009922 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 639283009923 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283009924 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283009925 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 639283009926 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283009927 catalytic loop [active] 639283009928 iron binding site [ion binding]; other site 639283009929 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 639283009930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283009931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283009932 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 639283009933 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 639283009934 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 639283009935 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283009936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283009937 dimer interface [polypeptide binding]; other site 639283009938 conserved gate region; other site 639283009939 putative PBP binding loops; other site 639283009940 ABC-ATPase subunit interface; other site 639283009941 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 639283009942 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283009943 Walker A/P-loop; other site 639283009944 ATP binding site [chemical binding]; other site 639283009945 Q-loop/lid; other site 639283009946 ABC transporter signature motif; other site 639283009947 Walker B; other site 639283009948 D-loop; other site 639283009949 H-loop/switch region; other site 639283009950 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 639283009951 active site 639283009952 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 639283009953 non-prolyl cis peptide bond; other site 639283009954 Flavin Reductases; Region: FlaRed; cl00801 639283009955 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 639283009956 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 639283009957 phosphate binding site [ion binding]; other site 639283009958 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 639283009959 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 639283009960 N- and C-terminal domain interface [polypeptide binding]; other site 639283009961 active site 639283009962 MgATP binding site [chemical binding]; other site 639283009963 catalytic site [active] 639283009964 metal binding site [ion binding]; metal-binding site 639283009965 glycerol binding site [chemical binding]; other site 639283009966 homotetramer interface [polypeptide binding]; other site 639283009967 homodimer interface [polypeptide binding]; other site 639283009968 FBP binding site [chemical binding]; other site 639283009969 protein IIAGlc interface [polypeptide binding]; other site 639283009970 Fusaric acid resistance protein family; Region: FUSC; pfam04632 639283009971 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 639283009972 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283009973 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283009974 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 639283009975 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 639283009976 active site 639283009977 homotetramer interface [polypeptide binding]; other site 639283009978 guanine deaminase; Provisional; Region: PRK09228 639283009979 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 639283009980 active site 639283009981 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 639283009982 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283009983 catalytic loop [active] 639283009984 iron binding site [ion binding]; other site 639283009985 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 639283009986 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 639283009987 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 639283009988 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283009989 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 639283009990 urate oxidase; Region: urate_oxi; TIGR03383 639283009991 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 639283009992 active site 639283009993 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 639283009994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283009995 NAD(P) binding site [chemical binding]; other site 639283009996 active site 639283009997 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 639283009998 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 639283009999 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 639283010000 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 639283010001 catalytic triad [active] 639283010002 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 639283010003 putative metal binding site [ion binding]; other site 639283010004 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283010005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010006 DNA-binding site [nucleotide binding]; DNA binding site 639283010007 FCD domain; Region: FCD; pfam07729 639283010008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 639283010009 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283010010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283010011 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 639283010012 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 639283010013 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 639283010014 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 639283010015 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 639283010016 putative active site [active] 639283010017 phosphogluconate dehydratase; Validated; Region: PRK09054 639283010018 6-phosphogluconate dehydratase; Region: edd; TIGR01196 639283010019 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 639283010020 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 639283010021 putative active site pocket [active] 639283010022 dimerization interface [polypeptide binding]; other site 639283010023 putative catalytic residue [active] 639283010024 Uncharacterized conserved protein [Function unknown]; Region: COG1434 639283010025 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 639283010026 putative active site [active] 639283010027 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 639283010028 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 639283010029 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 639283010030 Walker A/P-loop; other site 639283010031 ATP binding site [chemical binding]; other site 639283010032 Q-loop/lid; other site 639283010033 ABC transporter signature motif; other site 639283010034 Walker B; other site 639283010035 D-loop; other site 639283010036 H-loop/switch region; other site 639283010037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283010038 active site 639283010039 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 639283010040 diaminopimelate decarboxylase; Region: lysA; TIGR01048 639283010041 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 639283010042 active site 639283010043 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 639283010044 substrate binding site [chemical binding]; other site 639283010045 catalytic residues [active] 639283010046 dimer interface [polypeptide binding]; other site 639283010047 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 639283010048 putative catalytic site [active] 639283010049 putative phosphate binding site [ion binding]; other site 639283010050 active site 639283010051 metal binding site A [ion binding]; metal-binding site 639283010052 DNA binding site [nucleotide binding] 639283010053 putative AP binding site [nucleotide binding]; other site 639283010054 putative metal binding site B [ion binding]; other site 639283010055 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 639283010056 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 639283010057 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 639283010058 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 639283010059 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 639283010060 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 639283010061 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 639283010062 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283010063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283010064 homodimer interface [polypeptide binding]; other site 639283010065 catalytic residue [active] 639283010066 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 639283010067 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 639283010068 Nitrogen regulatory protein P-II; Region: P-II; smart00938 639283010069 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 639283010070 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 639283010071 active site 639283010072 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 639283010073 catalytic triad [active] 639283010074 dimer interface [polypeptide binding]; other site 639283010075 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 639283010076 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 639283010077 Uncharacterized conserved protein [Function unknown]; Region: COG2835 639283010078 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283010079 FCD domain; Region: FCD; pfam07729 639283010080 Peptidase C26; Region: Peptidase_C26; pfam07722 639283010081 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 639283010082 catalytic triad [active] 639283010083 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 639283010084 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 639283010085 putative deacylase active site [active] 639283010086 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 639283010087 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 639283010088 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 639283010089 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 639283010090 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283010091 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283010092 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283010093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283010094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283010095 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 639283010096 putative active site [active] 639283010097 Ap4A binding site [chemical binding]; other site 639283010098 nudix motif; other site 639283010099 putative metal binding site [ion binding]; other site 639283010100 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 639283010101 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 639283010102 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 639283010103 protein binding site [polypeptide binding]; other site 639283010104 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 639283010105 Catalytic dyad [active] 639283010106 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 639283010107 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 639283010108 oligomer interface [polypeptide binding]; other site 639283010109 Peptidase family M23; Region: Peptidase_M23; pfam01551 639283010110 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 639283010111 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 639283010112 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 639283010113 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 639283010114 Dienelactone hydrolase family; Region: DLH; pfam01738 639283010115 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 639283010116 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 639283010117 active site 639283010118 metal binding site [ion binding]; metal-binding site 639283010119 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 639283010120 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 639283010121 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 639283010122 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 639283010123 active site 639283010124 (T/H)XGH motif; other site 639283010125 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 639283010126 putative catalytic cysteine [active] 639283010127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283010128 Methyltransferase domain; Region: Methyltransf_31; pfam13847 639283010129 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 639283010130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 639283010131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283010132 putative Zn2+ binding site [ion binding]; other site 639283010133 putative DNA binding site [nucleotide binding]; other site 639283010134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 639283010135 Protein required for attachment to host cells; Region: Host_attach; pfam10116 639283010136 TspO/MBR family; Region: TspO_MBR; pfam03073 639283010137 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 639283010138 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 639283010139 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 639283010140 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 639283010141 Ligand binding site [chemical binding]; other site 639283010142 Electron transfer flavoprotein domain; Region: ETF; pfam01012 639283010143 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 639283010144 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 639283010145 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 639283010146 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 639283010147 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 639283010148 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 639283010149 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 639283010150 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 639283010151 putative NAD(P) binding site [chemical binding]; other site 639283010152 Cupin; Region: Cupin_6; pfam12852 639283010153 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283010154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283010155 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 639283010156 EamA-like transporter family; Region: EamA; pfam00892 639283010157 EamA-like transporter family; Region: EamA; pfam00892 639283010158 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 639283010159 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 639283010160 TIGR02594 family protein; Region: TIGR02594 639283010161 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 639283010162 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 639283010163 catalytic residues [active] 639283010164 argininosuccinate lyase; Provisional; Region: PRK00855 639283010165 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 639283010166 active sites [active] 639283010167 tetramer interface [polypeptide binding]; other site 639283010168 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 639283010169 metal-binding site [ion binding] 639283010170 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 639283010171 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 639283010172 Soluble P-type ATPase [General function prediction only]; Region: COG4087 639283010173 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 639283010174 DNA binding residues [nucleotide binding] 639283010175 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 639283010176 dimer interface [polypeptide binding]; other site 639283010177 putative metal binding site [ion binding]; other site 639283010178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283010179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283010180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283010181 LysR substrate binding domain; Region: LysR_substrate; pfam03466 639283010182 dimerization interface [polypeptide binding]; other site 639283010183 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 639283010184 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 639283010185 tetrameric interface [polypeptide binding]; other site 639283010186 NAD binding site [chemical binding]; other site 639283010187 catalytic residues [active] 639283010188 Predicted transcriptional regulator [Transcription]; Region: COG2378 639283010189 HTH domain; Region: HTH_11; pfam08279 639283010190 WYL domain; Region: WYL; pfam13280 639283010191 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 639283010192 putative dimer interface [polypeptide binding]; other site 639283010193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283010194 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 639283010195 prephenate dehydrogenase; Validated; Region: PRK08507 639283010196 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 639283010197 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283010198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283010199 homodimer interface [polypeptide binding]; other site 639283010200 catalytic residue [active] 639283010201 hypothetical protein; Provisional; Region: PRK06034 639283010202 Chorismate mutase type II; Region: CM_2; pfam01817 639283010203 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 639283010204 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 639283010205 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 639283010206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283010207 S-adenosylmethionine binding site [chemical binding]; other site 639283010208 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 639283010209 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 639283010210 Methyltransferase domain; Region: Methyltransf_23; pfam13489 639283010211 Methyltransferase domain; Region: Methyltransf_11; pfam08241 639283010212 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 639283010213 DEAD-like helicases superfamily; Region: DEXDc; smart00487 639283010214 ATP binding site [chemical binding]; other site 639283010215 Mg++ binding site [ion binding]; other site 639283010216 motif III; other site 639283010217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 639283010218 nucleotide binding region [chemical binding]; other site 639283010219 ATP-binding site [chemical binding]; other site 639283010220 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 639283010221 rRNA binding site [nucleotide binding]; other site 639283010222 predicted 30S ribosome binding site; other site 639283010223 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283010224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010225 DNA-binding site [nucleotide binding]; DNA binding site 639283010226 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 639283010227 Putative transcription activator [Transcription]; Region: TenA; COG0819 639283010228 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 639283010229 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 639283010230 gamma subunit interface [polypeptide binding]; other site 639283010231 epsilon subunit interface [polypeptide binding]; other site 639283010232 LBP interface [polypeptide binding]; other site 639283010233 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 639283010234 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 639283010235 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 639283010236 alpha subunit interaction interface [polypeptide binding]; other site 639283010237 Walker A motif; other site 639283010238 ATP binding site [chemical binding]; other site 639283010239 Walker B motif; other site 639283010240 inhibitor binding site; inhibition site 639283010241 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 639283010242 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 639283010243 core domain interface [polypeptide binding]; other site 639283010244 delta subunit interface [polypeptide binding]; other site 639283010245 epsilon subunit interface [polypeptide binding]; other site 639283010246 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 639283010247 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 639283010248 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 639283010249 beta subunit interaction interface [polypeptide binding]; other site 639283010250 Walker A motif; other site 639283010251 ATP binding site [chemical binding]; other site 639283010252 Walker B motif; other site 639283010253 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 639283010254 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 639283010255 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 639283010256 heme exporter protein CcmB; Region: ccmB; TIGR01190 639283010257 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 639283010258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283010259 Walker A/P-loop; other site 639283010260 ATP binding site [chemical binding]; other site 639283010261 Q-loop/lid; other site 639283010262 ABC transporter signature motif; other site 639283010263 Walker B; other site 639283010264 D-loop; other site 639283010265 H-loop/switch region; other site 639283010266 aconitate hydratase; Validated; Region: PRK09277 639283010267 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 639283010268 substrate binding site [chemical binding]; other site 639283010269 ligand binding site [chemical binding]; other site 639283010270 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 639283010271 substrate binding site [chemical binding]; other site 639283010272 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 639283010273 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 639283010274 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 639283010275 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 639283010276 putative active site; other site 639283010277 catalytic triad [active] 639283010278 putative dimer interface [polypeptide binding]; other site 639283010279 agmatine deiminase; Provisional; Region: PRK13551 639283010280 agmatine deiminase; Region: agmatine_aguA; TIGR03380 639283010281 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 639283010282 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 639283010283 NADP binding site [chemical binding]; other site 639283010284 putative substrate binding site [chemical binding]; other site 639283010285 active site 639283010286 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 639283010287 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 639283010288 putative active site [active] 639283010289 metal binding site [ion binding]; metal-binding site 639283010290 Acyltransferase family; Region: Acyl_transf_3; pfam01757 639283010291 AIR carboxylase; Region: AIRC; cl00310 639283010292 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 639283010293 Ligand Binding Site [chemical binding]; other site 639283010294 Protein of unknown function DUF111; Region: DUF111; cl03398 639283010295 Protein of unknown function DUF111; Region: DUF111; cl03398 639283010296 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 639283010297 selenophosphate synthetase; Provisional; Region: PRK00943 639283010298 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 639283010299 dimerization interface [polypeptide binding]; other site 639283010300 putative ATP binding site [chemical binding]; other site 639283010301 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 639283010302 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 639283010303 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 639283010304 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 639283010305 catalytic residues [active] 639283010306 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 639283010307 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 639283010308 [4Fe-4S] binding site [ion binding]; other site 639283010309 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 639283010310 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 639283010311 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 639283010312 molybdopterin cofactor binding site; other site 639283010313 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 639283010314 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 639283010315 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 639283010316 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 639283010317 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 639283010318 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 639283010319 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 639283010320 selenocysteine synthase; Provisional; Region: PRK04311 639283010321 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 639283010322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283010323 catalytic residue [active] 639283010324 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 639283010325 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 639283010326 G1 box; other site 639283010327 putative GEF interaction site [polypeptide binding]; other site 639283010328 GTP/Mg2+ binding site [chemical binding]; other site 639283010329 Switch I region; other site 639283010330 G2 box; other site 639283010331 G3 box; other site 639283010332 Switch II region; other site 639283010333 G4 box; other site 639283010334 G5 box; other site 639283010335 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 639283010336 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 639283010337 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 639283010338 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 639283010339 Major Facilitator Superfamily; Region: MFS_1; pfam07690 639283010340 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 639283010341 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283010342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010343 DNA-binding site [nucleotide binding]; DNA binding site 639283010344 FCD domain; Region: FCD; pfam07729 639283010345 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 639283010346 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 639283010347 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283010348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283010349 Walker A/P-loop; other site 639283010350 ATP binding site [chemical binding]; other site 639283010351 Q-loop/lid; other site 639283010352 ABC transporter signature motif; other site 639283010353 Walker B; other site 639283010354 D-loop; other site 639283010355 H-loop/switch region; other site 639283010356 TOBE domain; Region: TOBE_2; pfam08402 639283010357 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283010358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010359 dimer interface [polypeptide binding]; other site 639283010360 conserved gate region; other site 639283010361 putative PBP binding loops; other site 639283010362 ABC-ATPase subunit interface; other site 639283010363 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283010364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010365 dimer interface [polypeptide binding]; other site 639283010366 conserved gate region; other site 639283010367 putative PBP binding loops; other site 639283010368 ABC-ATPase subunit interface; other site 639283010369 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 639283010370 CoA-transferase family III; Region: CoA_transf_3; pfam02515 639283010371 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 639283010372 putative active site [active] 639283010373 putative catalytic site [active] 639283010374 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283010375 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 639283010376 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 639283010377 CoA-transferase family III; Region: CoA_transf_3; pfam02515 639283010378 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 639283010379 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 639283010380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010381 dimer interface [polypeptide binding]; other site 639283010382 conserved gate region; other site 639283010383 putative PBP binding loops; other site 639283010384 ABC-ATPase subunit interface; other site 639283010385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010386 dimer interface [polypeptide binding]; other site 639283010387 conserved gate region; other site 639283010388 putative PBP binding loops; other site 639283010389 ABC-ATPase subunit interface; other site 639283010390 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 639283010391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283010392 Walker A/P-loop; other site 639283010393 ATP binding site [chemical binding]; other site 639283010394 Q-loop/lid; other site 639283010395 ABC transporter signature motif; other site 639283010396 Walker B; other site 639283010397 D-loop; other site 639283010398 H-loop/switch region; other site 639283010399 TOBE domain; Region: TOBE_2; pfam08402 639283010400 Transcriptional regulators [Transcription]; Region: PurR; COG1609 639283010401 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 639283010402 DNA binding site [nucleotide binding] 639283010403 domain linker motif; other site 639283010404 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 639283010405 dimerization interface [polypeptide binding]; other site 639283010406 ligand binding site [chemical binding]; other site 639283010407 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 639283010408 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 639283010409 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 639283010410 active site 2 [active] 639283010411 active site 1 [active] 639283010412 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 639283010413 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 639283010414 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 639283010415 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 639283010416 Transcriptional regulators [Transcription]; Region: PurR; COG1609 639283010417 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 639283010418 DNA binding site [nucleotide binding] 639283010419 domain linker motif; other site 639283010420 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 639283010421 dimerization interface [polypeptide binding]; other site 639283010422 ligand binding site [chemical binding]; other site 639283010423 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 639283010424 active site 639283010425 catalytic residues [active] 639283010426 metal binding site [ion binding]; metal-binding site 639283010427 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 639283010428 Cupin; Region: Cupin_1; smart00835 639283010429 Cupin; Region: Cupin_1; smart00835 639283010430 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 639283010431 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 639283010432 putative molybdopterin cofactor binding site [chemical binding]; other site 639283010433 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 639283010434 putative molybdopterin cofactor binding site; other site 639283010435 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 639283010436 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 639283010437 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 639283010438 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 639283010439 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 639283010440 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 639283010441 Membrane transport protein; Region: Mem_trans; cl09117 639283010442 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 639283010443 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 639283010444 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283010445 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 639283010446 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283010447 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 639283010448 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283010449 catalytic loop [active] 639283010450 iron binding site [ion binding]; other site 639283010451 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 639283010452 Response regulator receiver domain; Region: Response_reg; pfam00072 639283010453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283010454 active site 639283010455 phosphorylation site [posttranslational modification] 639283010456 intermolecular recognition site; other site 639283010457 dimerization interface [polypeptide binding]; other site 639283010458 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 639283010459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283010460 active site 639283010461 phosphorylation site [posttranslational modification] 639283010462 intermolecular recognition site; other site 639283010463 dimerization interface [polypeptide binding]; other site 639283010464 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283010465 dimerization interface [polypeptide binding]; other site 639283010466 DNA binding residues [nucleotide binding] 639283010467 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283010468 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283010469 active site 639283010470 catalytic tetrad [active] 639283010471 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283010472 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 639283010473 Walker A/P-loop; other site 639283010474 ATP binding site [chemical binding]; other site 639283010475 Q-loop/lid; other site 639283010476 ABC transporter signature motif; other site 639283010477 Walker B; other site 639283010478 D-loop; other site 639283010479 H-loop/switch region; other site 639283010480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010481 dimer interface [polypeptide binding]; other site 639283010482 conserved gate region; other site 639283010483 putative PBP binding loops; other site 639283010484 ABC-ATPase subunit interface; other site 639283010485 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283010486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283010487 substrate binding pocket [chemical binding]; other site 639283010488 membrane-bound complex binding site; other site 639283010489 hinge residues; other site 639283010490 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 639283010491 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 639283010492 putative ligand binding site [chemical binding]; other site 639283010493 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283010494 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283010495 TM-ABC transporter signature motif; other site 639283010496 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 639283010497 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 639283010498 Walker A/P-loop; other site 639283010499 ATP binding site [chemical binding]; other site 639283010500 Q-loop/lid; other site 639283010501 ABC transporter signature motif; other site 639283010502 Walker B; other site 639283010503 D-loop; other site 639283010504 H-loop/switch region; other site 639283010505 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 639283010506 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 639283010507 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 639283010508 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 639283010509 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 639283010510 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 639283010511 Metal-binding active site; metal-binding site 639283010512 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 639283010513 Transcriptional regulators [Transcription]; Region: PurR; COG1609 639283010514 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 639283010515 DNA binding site [nucleotide binding] 639283010516 domain linker motif; other site 639283010517 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 639283010518 ligand binding site [chemical binding]; other site 639283010519 dimerization interface [polypeptide binding]; other site 639283010520 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 639283010521 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 639283010522 active site 639283010523 imidazolonepropionase; Validated; Region: PRK09356 639283010524 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 639283010525 active site 639283010526 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 639283010527 active sites [active] 639283010528 tetramer interface [polypeptide binding]; other site 639283010529 N-formylglutamate amidohydrolase; Region: FGase; cl01522 639283010530 urocanate hydratase; Provisional; Region: PRK05414 639283010531 HutD; Region: HutD; pfam05962 639283010532 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 639283010533 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 639283010534 active site 639283010535 non-prolyl cis peptide bond; other site 639283010536 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283010537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010538 dimer interface [polypeptide binding]; other site 639283010539 conserved gate region; other site 639283010540 putative PBP binding loops; other site 639283010541 ABC-ATPase subunit interface; other site 639283010542 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283010543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010544 dimer interface [polypeptide binding]; other site 639283010545 conserved gate region; other site 639283010546 putative PBP binding loops; other site 639283010547 ABC-ATPase subunit interface; other site 639283010548 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283010549 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 639283010550 Walker A/P-loop; other site 639283010551 ATP binding site [chemical binding]; other site 639283010552 Q-loop/lid; other site 639283010553 ABC transporter signature motif; other site 639283010554 Walker B; other site 639283010555 D-loop; other site 639283010556 H-loop/switch region; other site 639283010557 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283010558 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283010559 substrate binding pocket [chemical binding]; other site 639283010560 membrane-bound complex binding site; other site 639283010561 hinge residues; other site 639283010562 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 639283010563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010564 DNA-binding site [nucleotide binding]; DNA binding site 639283010565 UTRA domain; Region: UTRA; pfam07702 639283010566 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 639283010567 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283010568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283010569 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 639283010570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010571 DNA-binding site [nucleotide binding]; DNA binding site 639283010572 FCD domain; Region: FCD; pfam07729 639283010573 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 639283010574 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 639283010575 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 639283010576 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 639283010577 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 639283010578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 639283010579 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 639283010580 ABC transporter; Region: ABC_tran_2; pfam12848 639283010581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 639283010582 trehalose synthase; Region: treS_nterm; TIGR02456 639283010583 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 639283010584 active site 639283010585 catalytic site [active] 639283010586 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 639283010587 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 639283010588 active site 639283010589 catalytic site [active] 639283010590 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 639283010591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 639283010592 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 639283010593 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 639283010594 Ligand binding site; other site 639283010595 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 639283010596 DXD motif; other site 639283010597 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 639283010598 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 639283010599 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 639283010600 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 639283010601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283010602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283010603 active site 639283010604 catalytic tetrad [active] 639283010605 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 639283010606 Autotransporter beta-domain; Region: Autotransporter; pfam03797 639283010607 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 639283010608 folate binding site [chemical binding]; other site 639283010609 NADP+ binding site [chemical binding]; other site 639283010610 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 639283010611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283010612 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 639283010613 putative dimerization interface [polypeptide binding]; other site 639283010614 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 639283010615 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283010616 putative ligand binding site [chemical binding]; other site 639283010617 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283010618 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283010619 TM-ABC transporter signature motif; other site 639283010620 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283010621 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283010622 TM-ABC transporter signature motif; other site 639283010623 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283010624 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283010625 Walker A/P-loop; other site 639283010626 ATP binding site [chemical binding]; other site 639283010627 Q-loop/lid; other site 639283010628 ABC transporter signature motif; other site 639283010629 Walker B; other site 639283010630 D-loop; other site 639283010631 H-loop/switch region; other site 639283010632 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283010633 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283010634 Walker A/P-loop; other site 639283010635 ATP binding site [chemical binding]; other site 639283010636 Q-loop/lid; other site 639283010637 ABC transporter signature motif; other site 639283010638 Walker B; other site 639283010639 D-loop; other site 639283010640 H-loop/switch region; other site 639283010641 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 639283010642 Amidase; Region: Amidase; pfam01425 639283010643 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 639283010644 nucleoside/Zn binding site; other site 639283010645 dimer interface [polypeptide binding]; other site 639283010646 catalytic motif [active] 639283010647 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 639283010648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283010649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010650 dimer interface [polypeptide binding]; other site 639283010651 conserved gate region; other site 639283010652 putative PBP binding loops; other site 639283010653 ABC-ATPase subunit interface; other site 639283010654 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283010655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010656 dimer interface [polypeptide binding]; other site 639283010657 conserved gate region; other site 639283010658 putative PBP binding loops; other site 639283010659 ABC-ATPase subunit interface; other site 639283010660 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283010661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283010662 Walker A/P-loop; other site 639283010663 ATP binding site [chemical binding]; other site 639283010664 Q-loop/lid; other site 639283010665 ABC transporter signature motif; other site 639283010666 Walker B; other site 639283010667 D-loop; other site 639283010668 H-loop/switch region; other site 639283010669 TOBE domain; Region: TOBE_2; pfam08402 639283010670 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 639283010671 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 639283010672 active site 639283010673 putative substrate binding pocket [chemical binding]; other site 639283010674 Creatinine amidohydrolase; Region: Creatininase; pfam02633 639283010675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283010676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283010677 amidase; Provisional; Region: PRK08310 639283010678 indole-3-acetamide amidohydrolase; Region: PLN02722 639283010679 cytosine deaminase; Provisional; Region: PRK05985 639283010680 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 639283010681 active site 639283010682 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283010683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010684 DNA-binding site [nucleotide binding]; DNA binding site 639283010685 FCD domain; Region: FCD; pfam07729 639283010686 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 639283010687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 639283010688 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 639283010689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 639283010690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010691 dimer interface [polypeptide binding]; other site 639283010692 conserved gate region; other site 639283010693 putative PBP binding loops; other site 639283010694 ABC-ATPase subunit interface; other site 639283010695 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 639283010696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010697 dimer interface [polypeptide binding]; other site 639283010698 conserved gate region; other site 639283010699 putative PBP binding loops; other site 639283010700 ABC-ATPase subunit interface; other site 639283010701 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 639283010702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 639283010703 Walker A/P-loop; other site 639283010704 ATP binding site [chemical binding]; other site 639283010705 Q-loop/lid; other site 639283010706 ABC transporter signature motif; other site 639283010707 Walker B; other site 639283010708 D-loop; other site 639283010709 H-loop/switch region; other site 639283010710 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 639283010711 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 639283010712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 639283010713 Walker A/P-loop; other site 639283010714 ATP binding site [chemical binding]; other site 639283010715 Q-loop/lid; other site 639283010716 ABC transporter signature motif; other site 639283010717 Walker B; other site 639283010718 D-loop; other site 639283010719 H-loop/switch region; other site 639283010720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 639283010721 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 639283010722 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283010723 active site 639283010724 GAF domain; Region: GAF; cl17456 639283010725 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 639283010726 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 639283010727 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 639283010728 DctM-like transporters; Region: DctM; pfam06808 639283010729 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 639283010730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283010731 Coenzyme A binding pocket [chemical binding]; other site 639283010732 septum formation inhibitor; Reviewed; Region: minC; PRK05177 639283010733 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 639283010734 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 639283010735 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 639283010736 Switch II; other site 639283010737 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 639283010738 hypothetical protein; Provisional; Region: PRK06184 639283010739 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 639283010740 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 639283010741 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 639283010742 metal binding site [ion binding]; metal-binding site 639283010743 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 639283010744 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 639283010745 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 639283010746 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 639283010747 ABC-ATPase subunit interface; other site 639283010748 dimer interface [polypeptide binding]; other site 639283010749 putative PBP binding regions; other site 639283010750 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 639283010751 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 639283010752 ABC-ATPase subunit interface; other site 639283010753 dimer interface [polypeptide binding]; other site 639283010754 putative PBP binding regions; other site 639283010755 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 639283010756 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 639283010757 Walker A/P-loop; other site 639283010758 ATP binding site [chemical binding]; other site 639283010759 Q-loop/lid; other site 639283010760 ABC transporter signature motif; other site 639283010761 Walker B; other site 639283010762 D-loop; other site 639283010763 H-loop/switch region; other site 639283010764 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 639283010765 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 639283010766 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 639283010767 ABC-ATPase subunit interface; other site 639283010768 dimer interface [polypeptide binding]; other site 639283010769 putative PBP binding regions; other site 639283010770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 639283010771 ABC-ATPase subunit interface; other site 639283010772 dimer interface [polypeptide binding]; other site 639283010773 putative PBP binding regions; other site 639283010774 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 639283010775 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 639283010776 siderophore binding site; other site 639283010777 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 639283010778 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 639283010779 N-terminal plug; other site 639283010780 ligand-binding site [chemical binding]; other site 639283010781 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 639283010782 FecR protein; Region: FecR; pfam04773 639283010783 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 639283010784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283010785 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 639283010786 DNA binding residues [nucleotide binding] 639283010787 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 639283010788 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 639283010789 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 639283010790 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 639283010791 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 639283010792 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283010793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010794 DNA-binding site [nucleotide binding]; DNA binding site 639283010795 FCD domain; Region: FCD; pfam07729 639283010796 enoyl-CoA hydratase; Provisional; Region: PRK06144 639283010797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 639283010798 substrate binding site [chemical binding]; other site 639283010799 oxyanion hole (OAH) forming residues; other site 639283010800 trimer interface [polypeptide binding]; other site 639283010801 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 639283010802 CoA-transferase family III; Region: CoA_transf_3; pfam02515 639283010803 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283010804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010805 DNA-binding site [nucleotide binding]; DNA binding site 639283010806 FCD domain; Region: FCD; pfam07729 639283010807 succinic semialdehyde dehydrogenase; Region: PLN02278 639283010808 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 639283010809 tetramerization interface [polypeptide binding]; other site 639283010810 NAD(P) binding site [chemical binding]; other site 639283010811 catalytic residues [active] 639283010812 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 639283010813 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 639283010814 active site 639283010815 NAD binding site [chemical binding]; other site 639283010816 metal binding site [ion binding]; metal-binding site 639283010817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 639283010818 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283010819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283010820 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 639283010821 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 639283010822 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 639283010823 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 639283010824 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283010825 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283010826 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 639283010827 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 639283010828 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 639283010829 dimer interface [polypeptide binding]; other site 639283010830 active site 639283010831 catalytic residue [active] 639283010832 metal binding site [ion binding]; metal-binding site 639283010833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 639283010834 WLM domain; Region: WLM; pfam08325 639283010835 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 639283010836 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 639283010837 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 639283010838 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 639283010839 DctM-like transporters; Region: DctM; pfam06808 639283010840 transcriptional regulator NanR; Provisional; Region: PRK03837 639283010841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010842 DNA-binding site [nucleotide binding]; DNA binding site 639283010843 FCD domain; Region: FCD; pfam07729 639283010844 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283010845 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283010846 TM-ABC transporter signature motif; other site 639283010847 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 639283010848 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 639283010849 Walker A/P-loop; other site 639283010850 ATP binding site [chemical binding]; other site 639283010851 Q-loop/lid; other site 639283010852 ABC transporter signature motif; other site 639283010853 Walker B; other site 639283010854 D-loop; other site 639283010855 H-loop/switch region; other site 639283010856 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 639283010857 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283010858 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 639283010859 TM-ABC transporter signature motif; other site 639283010860 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 639283010861 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 639283010862 putative ligand binding site [chemical binding]; other site 639283010863 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 639283010864 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 639283010865 Domain interface; other site 639283010866 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 639283010867 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 639283010868 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 639283010869 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 639283010870 nucleotide binding site [chemical binding]; other site 639283010871 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 639283010872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283010873 Coenzyme A binding pocket [chemical binding]; other site 639283010874 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 639283010875 hydrophobic ligand binding site; other site 639283010876 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 639283010877 putative hydrophobic ligand binding site [chemical binding]; other site 639283010878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283010879 dimerization interface [polypeptide binding]; other site 639283010880 putative DNA binding site [nucleotide binding]; other site 639283010881 putative Zn2+ binding site [ion binding]; other site 639283010882 RibD C-terminal domain; Region: RibD_C; cl17279 639283010883 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 639283010884 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 639283010885 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 639283010886 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 639283010887 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 639283010888 GTPase CgtA; Reviewed; Region: obgE; PRK12299 639283010889 GTP1/OBG; Region: GTP1_OBG; pfam01018 639283010890 Obg GTPase; Region: Obg; cd01898 639283010891 G1 box; other site 639283010892 GTP/Mg2+ binding site [chemical binding]; other site 639283010893 Switch I region; other site 639283010894 G2 box; other site 639283010895 G3 box; other site 639283010896 Switch II region; other site 639283010897 G4 box; other site 639283010898 G5 box; other site 639283010899 gamma-glutamyl kinase; Provisional; Region: PRK05429 639283010900 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 639283010901 nucleotide binding site [chemical binding]; other site 639283010902 homotetrameric interface [polypeptide binding]; other site 639283010903 putative phosphate binding site [ion binding]; other site 639283010904 putative allosteric binding site; other site 639283010905 PUA domain; Region: PUA; pfam01472 639283010906 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 639283010907 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 639283010908 Beta-lactamase; Region: Beta-lactamase; pfam00144 639283010909 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 639283010910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283010911 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283010912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283010913 Walker A/P-loop; other site 639283010914 ATP binding site [chemical binding]; other site 639283010915 Q-loop/lid; other site 639283010916 ABC transporter signature motif; other site 639283010917 Walker B; other site 639283010918 D-loop; other site 639283010919 H-loop/switch region; other site 639283010920 TOBE domain; Region: TOBE_2; pfam08402 639283010921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283010922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010923 dimer interface [polypeptide binding]; other site 639283010924 ABC-ATPase subunit interface; other site 639283010925 putative PBP binding loops; other site 639283010926 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283010927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283010928 dimer interface [polypeptide binding]; other site 639283010929 conserved gate region; other site 639283010930 ABC-ATPase subunit interface; other site 639283010931 Protein of unknown function DUF72; Region: DUF72; pfam01904 639283010932 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 639283010933 Peptidase family M48; Region: Peptidase_M48; cl12018 639283010934 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 639283010935 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283010936 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 639283010937 DNA binding residues [nucleotide binding] 639283010938 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 639283010939 Ferredoxin [Energy production and conversion]; Region: COG1146 639283010940 4Fe-4S binding domain; Region: Fer4; cl02805 639283010941 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 639283010942 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 639283010943 RNA binding surface [nucleotide binding]; other site 639283010944 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 639283010945 DEAD/DEAH box helicase; Region: DEAD; pfam00270 639283010946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 639283010947 nucleotide binding region [chemical binding]; other site 639283010948 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 639283010949 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 639283010950 camphor resistance protein CrcB; Provisional; Region: PRK14198 639283010951 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 639283010952 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 639283010953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 639283010954 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 639283010955 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 639283010956 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 639283010957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283010958 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 639283010959 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 639283010960 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 639283010961 catalytic residues [active] 639283010962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 639283010963 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 639283010964 substrate binding site [chemical binding]; other site 639283010965 Predicted kinase [General function prediction only]; Region: COG0645 639283010966 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 639283010967 active site 639283010968 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 639283010969 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 639283010970 tetramer interface [polypeptide binding]; other site 639283010971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283010972 catalytic residue [active] 639283010973 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 639283010974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283010975 DNA-binding site [nucleotide binding]; DNA binding site 639283010976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 639283010977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283010978 homodimer interface [polypeptide binding]; other site 639283010979 catalytic residue [active] 639283010980 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 639283010981 Predicted amidohydrolase [General function prediction only]; Region: COG0388 639283010982 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 639283010983 putative active site [active] 639283010984 catalytic triad [active] 639283010985 putative dimer interface [polypeptide binding]; other site 639283010986 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 639283010987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283010988 Coenzyme A binding pocket [chemical binding]; other site 639283010989 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 639283010990 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 639283010991 dimerization interface [polypeptide binding]; other site 639283010992 putative ATP binding site [chemical binding]; other site 639283010993 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 639283010994 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 639283010995 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 639283010996 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 639283010997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 639283010998 probable biosynthetic protein, Pnap_2097 family; Region: biosn_Pnap_2097; TIGR04099 639283010999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283011000 dimer interface [polypeptide binding]; other site 639283011001 conserved gate region; other site 639283011002 putative PBP binding loops; other site 639283011003 ABC-ATPase subunit interface; other site 639283011004 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 639283011005 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 639283011006 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283011007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283011008 dimer interface [polypeptide binding]; other site 639283011009 conserved gate region; other site 639283011010 putative PBP binding loops; other site 639283011011 ABC-ATPase subunit interface; other site 639283011012 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 639283011013 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 639283011014 Walker A/P-loop; other site 639283011015 ATP binding site [chemical binding]; other site 639283011016 Q-loop/lid; other site 639283011017 ABC transporter signature motif; other site 639283011018 Walker B; other site 639283011019 D-loop; other site 639283011020 H-loop/switch region; other site 639283011021 TOBE domain; Region: TOBE_2; pfam08402 639283011022 sorbitol dehydrogenase; Provisional; Region: PRK07067 639283011023 classical (c) SDRs; Region: SDR_c; cd05233 639283011024 NAD(P) binding site [chemical binding]; other site 639283011025 active site 639283011026 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 639283011027 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 639283011028 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 639283011029 BtpA family; Region: BtpA; cl00440 639283011030 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 639283011031 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 639283011032 N- and C-terminal domain interface [polypeptide binding]; other site 639283011033 putative active site [active] 639283011034 MgATP binding site [chemical binding]; other site 639283011035 catalytic site [active] 639283011036 metal binding site [ion binding]; metal-binding site 639283011037 putative xylulose binding site [chemical binding]; other site 639283011038 putative homodimer interface [polypeptide binding]; other site 639283011039 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 639283011040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283011041 motif II; other site 639283011042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283011043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283011044 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 639283011045 putative effector binding pocket; other site 639283011046 dimerization interface [polypeptide binding]; other site 639283011047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283011048 NmrA-like family; Region: NmrA; pfam05368 639283011049 NAD(P) binding site [chemical binding]; other site 639283011050 active site 639283011051 glucosyltransferase MdoH; Provisional; Region: PRK05454 639283011052 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 639283011053 active site 639283011054 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 639283011055 putative NAD(P) binding site [chemical binding]; other site 639283011056 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 639283011057 active site 639283011058 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283011059 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 639283011060 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 639283011061 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 639283011062 RibD C-terminal domain; Region: RibD_C; pfam01872 639283011063 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 639283011064 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 639283011065 nudix motif; other site 639283011066 NAD synthetase; Reviewed; Region: nadE; PRK02628 639283011067 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 639283011068 multimer interface [polypeptide binding]; other site 639283011069 active site 639283011070 catalytic triad [active] 639283011071 protein interface 1 [polypeptide binding]; other site 639283011072 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 639283011073 homodimer interface [polypeptide binding]; other site 639283011074 NAD binding pocket [chemical binding]; other site 639283011075 ATP binding pocket [chemical binding]; other site 639283011076 Mg binding site [ion binding]; other site 639283011077 active-site loop [active] 639283011078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 639283011079 active site 639283011080 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 639283011081 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 639283011082 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283011083 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 639283011084 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 639283011085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283011086 Phospholipid methyltransferase; Region: PEMT; cl17370 639283011087 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 639283011088 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 639283011089 malonyl-CoA binding site [chemical binding]; other site 639283011090 dimer interface [polypeptide binding]; other site 639283011091 active site 639283011092 product binding site; other site 639283011093 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 639283011094 putative heme binding pocket [chemical binding]; other site 639283011095 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 639283011096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283011097 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283011098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283011099 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283011100 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283011101 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283011102 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 639283011103 Protein export membrane protein; Region: SecD_SecF; cl14618 639283011104 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 639283011105 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283011106 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283011107 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 639283011108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283011109 putative substrate translocation pore; other site 639283011110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283011111 PAS domain S-box; Region: sensory_box; TIGR00229 639283011112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283011113 putative active site [active] 639283011114 heme pocket [chemical binding]; other site 639283011115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283011116 dimer interface [polypeptide binding]; other site 639283011117 phosphorylation site [posttranslational modification] 639283011118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283011119 ATP binding site [chemical binding]; other site 639283011120 G-X-G motif; other site 639283011121 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 639283011122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283011123 active site 639283011124 phosphorylation site [posttranslational modification] 639283011125 intermolecular recognition site; other site 639283011126 dimerization interface [polypeptide binding]; other site 639283011127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283011128 DNA binding residues [nucleotide binding] 639283011129 dimerization interface [polypeptide binding]; other site 639283011130 Response regulator receiver domain; Region: Response_reg; pfam00072 639283011131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283011132 active site 639283011133 phosphorylation site [posttranslational modification] 639283011134 intermolecular recognition site; other site 639283011135 dimerization interface [polypeptide binding]; other site 639283011136 Secretory lipase; Region: LIP; pfam03583 639283011137 Cupin; Region: Cupin_6; pfam12852 639283011138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283011139 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283011140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283011141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283011142 putative substrate translocation pore; other site 639283011143 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 639283011144 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 639283011145 Ligand binding site; other site 639283011146 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 639283011147 Putative Catalytic site; other site 639283011148 DXD motif; other site 639283011149 Methyltransferase domain; Region: Methyltransf_23; pfam13489 639283011150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283011151 S-adenosylmethionine binding site [chemical binding]; other site 639283011152 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 639283011153 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283011154 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283011155 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 639283011156 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 639283011157 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283011158 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 639283011159 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 639283011160 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 639283011161 NADP-binding site; other site 639283011162 homotetramer interface [polypeptide binding]; other site 639283011163 substrate binding site [chemical binding]; other site 639283011164 homodimer interface [polypeptide binding]; other site 639283011165 active site 639283011166 phosphomannomutase CpsG; Provisional; Region: PRK15414 639283011167 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 639283011168 active site 639283011169 substrate binding site [chemical binding]; other site 639283011170 metal binding site [ion binding]; metal-binding site 639283011171 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 639283011172 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 639283011173 Substrate binding site; other site 639283011174 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 639283011175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283011176 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 639283011177 allophanate hydrolase; Provisional; Region: PRK08186 639283011178 Amidase; Region: Amidase; cl11426 639283011179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283011180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283011181 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283011182 dimerization interface [polypeptide binding]; other site 639283011183 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 639283011184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283011185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283011186 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 639283011187 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 639283011188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 639283011189 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 639283011190 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 639283011191 active site 639283011192 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283011193 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 639283011194 Methyltransferase domain; Region: Methyltransf_24; pfam13578 639283011195 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 639283011196 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 639283011197 Probable Catalytic site; other site 639283011198 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 639283011199 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 639283011200 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 639283011201 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 639283011202 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 639283011203 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 639283011204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283011205 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 639283011206 putative dimerization interface [polypeptide binding]; other site 639283011207 Predicted membrane protein [Function unknown]; Region: COG2855 639283011208 Peptidase family M48; Region: Peptidase_M48; cl12018 639283011209 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 639283011210 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 639283011211 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 639283011212 nucleoside/Zn binding site; other site 639283011213 dimer interface [polypeptide binding]; other site 639283011214 catalytic motif [active] 639283011215 hypothetical protein; Provisional; Region: PRK09256 639283011216 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 639283011217 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 639283011218 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 639283011219 ligand binding site [chemical binding]; other site 639283011220 flexible hinge region; other site 639283011221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283011222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283011223 active site 639283011224 phosphorylation site [posttranslational modification] 639283011225 intermolecular recognition site; other site 639283011226 dimerization interface [polypeptide binding]; other site 639283011227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283011228 DNA binding site [nucleotide binding] 639283011229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 639283011230 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 639283011231 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 639283011232 catalytic residue [active] 639283011233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283011234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283011235 metal binding site [ion binding]; metal-binding site 639283011236 active site 639283011237 I-site; other site 639283011238 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 639283011239 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 639283011240 HIGH motif; other site 639283011241 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 639283011242 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 639283011243 active site 639283011244 KMSKS motif; other site 639283011245 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 639283011246 tRNA binding surface [nucleotide binding]; other site 639283011247 Lipopolysaccharide-assembly; Region: LptE; cl01125 639283011248 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 639283011249 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 639283011250 ParB-like nuclease domain; Region: ParBc; pfam02195 639283011251 KorB domain; Region: KorB; pfam08535 639283011252 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 639283011253 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 639283011254 P-loop; other site 639283011255 Magnesium ion binding site [ion binding]; other site 639283011256 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 639283011257 Magnesium ion binding site [ion binding]; other site 639283011258 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 639283011259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283011260 S-adenosylmethionine binding site [chemical binding]; other site 639283011261 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 639283011262 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 639283011263 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 639283011264 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 639283011265 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 639283011266 trmE is a tRNA modification GTPase; Region: trmE; cd04164 639283011267 G1 box; other site 639283011268 GTP/Mg2+ binding site [chemical binding]; other site 639283011269 Switch I region; other site 639283011270 G2 box; other site 639283011271 Switch II region; other site 639283011272 G3 box; other site 639283011273 G4 box; other site 639283011274 G5 box; other site 639283011275 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 639283011276 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 639283011277 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 639283011278 catalytic residues [active] 639283011279 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 639283011280 transcription termination factor Rho; Provisional; Region: rho; PRK09376 639283011281 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 639283011282 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 639283011283 RNA binding site [nucleotide binding]; other site 639283011284 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 639283011285 multimer interface [polypeptide binding]; other site 639283011286 Walker A motif; other site 639283011287 ATP binding site [chemical binding]; other site 639283011288 Walker B motif; other site 639283011289 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 639283011290 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 639283011291 substrate binding site [chemical binding]; other site 639283011292 active site 639283011293 PEP synthetase regulatory protein; Provisional; Region: PRK05339 639283011294 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 639283011295 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 639283011296 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 639283011297 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 639283011298 shikimate binding site; other site 639283011299 NAD(P) binding site [chemical binding]; other site 639283011300 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 639283011301 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 639283011302 CoA-binding site [chemical binding]; other site 639283011303 ATP-binding [chemical binding]; other site 639283011304 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 639283011305 active site 639283011306 catalytic site [active] 639283011307 substrate binding site [chemical binding]; other site 639283011308 preprotein translocase subunit SecB; Validated; Region: PRK05751 639283011309 SecA binding site; other site 639283011310 Preprotein binding site; other site 639283011311 Tim44-like domain; Region: Tim44; pfam04280 639283011312 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 639283011313 MltA specific insert domain; Region: MltA; smart00925 639283011314 3D domain; Region: 3D; pfam06725 639283011315 Smr domain; Region: Smr; pfam01713 639283011316 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283011317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283011318 sequence-specific DNA binding site [nucleotide binding]; other site 639283011319 salt bridge; other site 639283011320 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 639283011321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283011322 Walker A motif; other site 639283011323 ATP binding site [chemical binding]; other site 639283011324 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 639283011325 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 639283011326 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 639283011327 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 639283011328 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 639283011329 Coenzyme A binding pocket [chemical binding]; other site 639283011330 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 639283011331 active site 639283011332 HslU subunit interaction site [polypeptide binding]; other site 639283011333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283011334 putative substrate translocation pore; other site 639283011335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 639283011336 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 639283011337 putative active site pocket [active] 639283011338 4-fold oligomerization interface [polypeptide binding]; other site 639283011339 metal binding residues [ion binding]; metal-binding site 639283011340 3-fold/trimer interface [polypeptide binding]; other site 639283011341 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 639283011342 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 639283011343 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 639283011344 putative active site [active] 639283011345 oxyanion strand; other site 639283011346 catalytic triad [active] 639283011347 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 639283011348 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 639283011349 catalytic residues [active] 639283011350 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 639283011351 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 639283011352 substrate binding site [chemical binding]; other site 639283011353 glutamase interaction surface [polypeptide binding]; other site 639283011354 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 639283011355 metal binding site [ion binding]; metal-binding site 639283011356 pantothenate kinase; Provisional; Region: PRK05439 639283011357 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 639283011358 ATP-binding site [chemical binding]; other site 639283011359 CoA-binding site [chemical binding]; other site 639283011360 Mg2+-binding site [ion binding]; other site 639283011361 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 639283011362 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 639283011363 dimer interface [polypeptide binding]; other site 639283011364 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 639283011365 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 639283011366 ribonuclease PH; Reviewed; Region: rph; PRK00173 639283011367 Ribonuclease PH; Region: RNase_PH_bact; cd11362 639283011368 hexamer interface [polypeptide binding]; other site 639283011369 active site 639283011370 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 639283011371 active site 639283011372 dimerization interface [polypeptide binding]; other site 639283011373 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 639283011374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283011375 FeS/SAM binding site; other site 639283011376 HemN C-terminal domain; Region: HemN_C; pfam06969 639283011377 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 639283011378 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283011379 putative ligand binding site [chemical binding]; other site 639283011380 Predicted methyltransferases [General function prediction only]; Region: COG0313 639283011381 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 639283011382 putative SAM binding site [chemical binding]; other site 639283011383 putative homodimer interface [polypeptide binding]; other site 639283011384 hypothetical protein; Reviewed; Region: PRK12497 639283011385 glutathione synthetase; Provisional; Region: PRK05246 639283011386 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 639283011387 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 639283011388 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 639283011389 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 639283011390 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 639283011391 putative dimer interface [polypeptide binding]; other site 639283011392 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 639283011393 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 639283011394 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 639283011395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283011396 Walker A motif; other site 639283011397 ATP binding site [chemical binding]; other site 639283011398 Walker B motif; other site 639283011399 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 639283011400 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 639283011401 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 639283011402 putative dimer interface [polypeptide binding]; other site 639283011403 [2Fe-2S] cluster binding site [ion binding]; other site 639283011404 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 639283011405 putative dimer interface [polypeptide binding]; other site 639283011406 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 639283011407 SLBB domain; Region: SLBB; pfam10531 639283011408 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 639283011409 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 639283011410 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283011411 catalytic loop [active] 639283011412 iron binding site [ion binding]; other site 639283011413 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 639283011414 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 639283011415 [4Fe-4S] binding site [ion binding]; other site 639283011416 molybdopterin cofactor binding site; other site 639283011417 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 639283011418 molybdopterin cofactor binding site; other site 639283011419 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 639283011420 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 639283011421 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 639283011422 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 639283011423 TrkA-N domain; Region: TrkA_N; pfam02254 639283011424 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 639283011425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283011426 active site 639283011427 motif I; other site 639283011428 motif II; other site 639283011429 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 639283011430 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 639283011431 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 639283011432 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 639283011433 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 639283011434 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 639283011435 Cache domain; Region: Cache_1; pfam02743 639283011436 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 639283011437 GAF domain; Region: GAF_3; pfam13492 639283011438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 639283011439 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 639283011440 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 639283011441 dimer interface [polypeptide binding]; other site 639283011442 PYR/PP interface [polypeptide binding]; other site 639283011443 TPP binding site [chemical binding]; other site 639283011444 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 639283011445 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 639283011446 TPP-binding site [chemical binding]; other site 639283011447 dimer interface [polypeptide binding]; other site 639283011448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 639283011449 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 639283011450 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 639283011451 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 639283011452 hinge; other site 639283011453 active site 639283011454 cytidylate kinase; Provisional; Region: cmk; PRK00023 639283011455 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 639283011456 CMP-binding site; other site 639283011457 The sites determining sugar specificity; other site 639283011458 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 639283011459 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 639283011460 active site 639283011461 SAM binding site [chemical binding]; other site 639283011462 homodimer interface [polypeptide binding]; other site 639283011463 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 639283011464 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 639283011465 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283011466 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 639283011467 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 639283011468 RNA binding site [nucleotide binding]; other site 639283011469 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 639283011470 RNA binding site [nucleotide binding]; other site 639283011471 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 639283011472 RNA binding site [nucleotide binding]; other site 639283011473 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 639283011474 RNA binding site [nucleotide binding]; other site 639283011475 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 639283011476 RNA binding site [nucleotide binding]; other site 639283011477 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 639283011478 RNA binding site [nucleotide binding]; other site 639283011479 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 639283011480 maltose O-acetyltransferase; Provisional; Region: PRK10092 639283011481 Maltose acetyltransferase; Region: Mac; pfam12464 639283011482 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 639283011483 trimer interface [polypeptide binding]; other site 639283011484 active site 639283011485 substrate binding site [chemical binding]; other site 639283011486 CoA binding site [chemical binding]; other site 639283011487 ferrochelatase; Reviewed; Region: hemH; PRK00035 639283011488 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 639283011489 C-terminal domain interface [polypeptide binding]; other site 639283011490 active site 639283011491 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 639283011492 active site 639283011493 N-terminal domain interface [polypeptide binding]; other site 639283011494 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 639283011495 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 639283011496 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 639283011497 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 639283011498 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 639283011499 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 639283011500 putative C-terminal domain interface [polypeptide binding]; other site 639283011501 putative GSH binding site (G-site) [chemical binding]; other site 639283011502 putative dimer interface [polypeptide binding]; other site 639283011503 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 639283011504 putative N-terminal domain interface [polypeptide binding]; other site 639283011505 putative dimer interface [polypeptide binding]; other site 639283011506 putative substrate binding pocket (H-site) [chemical binding]; other site 639283011507 DNA polymerase I; Provisional; Region: PRK05755 639283011508 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 639283011509 active site 639283011510 metal binding site 1 [ion binding]; metal-binding site 639283011511 putative 5' ssDNA interaction site; other site 639283011512 metal binding site 3; metal-binding site 639283011513 metal binding site 2 [ion binding]; metal-binding site 639283011514 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 639283011515 putative DNA binding site [nucleotide binding]; other site 639283011516 putative metal binding site [ion binding]; other site 639283011517 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 639283011518 active site 639283011519 catalytic site [active] 639283011520 substrate binding site [chemical binding]; other site 639283011521 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 639283011522 active site 639283011523 DNA binding site [nucleotide binding] 639283011524 catalytic site [active] 639283011525 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 639283011526 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 639283011527 dimerization interface 3.5A [polypeptide binding]; other site 639283011528 active site 639283011529 dihydroorotase; Validated; Region: PRK09060 639283011530 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283011531 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 639283011532 active site 639283011533 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 639283011534 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 639283011535 ligand binding site [chemical binding]; other site 639283011536 flexible hinge region; other site 639283011537 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 639283011538 MarC family integral membrane protein; Region: MarC; cl00919 639283011539 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 639283011540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283011541 active site 639283011542 motif I; other site 639283011543 motif II; other site 639283011544 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 639283011545 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 639283011546 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 639283011547 active site 639283011548 Riboflavin kinase; Region: Flavokinase; pfam01687 639283011549 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 639283011550 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 639283011551 active site 639283011552 HIGH motif; other site 639283011553 nucleotide binding site [chemical binding]; other site 639283011554 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 639283011555 active site 639283011556 KMSKS motif; other site 639283011557 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 639283011558 tRNA binding surface [nucleotide binding]; other site 639283011559 anticodon binding site; other site 639283011560 lipoprotein signal peptidase; Provisional; Region: PRK14796 639283011561 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 639283011562 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 639283011563 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 639283011564 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 639283011565 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 639283011566 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 639283011567 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 639283011568 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 639283011569 nucleophilic elbow; other site 639283011570 catalytic triad; other site 639283011571 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 639283011572 FAD binding domain; Region: FAD_binding_4; pfam01565 639283011573 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 639283011574 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 639283011575 active site 639283011576 putative substrate binding pocket [chemical binding]; other site 639283011577 FAD binding domain; Region: FAD_binding_4; pfam01565 639283011578 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 639283011579 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 639283011580 Cysteine-rich domain; Region: CCG; pfam02754 639283011581 Cysteine-rich domain; Region: CCG; pfam02754 639283011582 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 639283011583 active site 639283011584 homotetramer interface [polypeptide binding]; other site 639283011585 homodimer interface [polypeptide binding]; other site 639283011586 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 639283011587 diiron binding motif [ion binding]; other site 639283011588 Uncharacterized conserved protein [Function unknown]; Region: COG1633 639283011589 CCC1-related protein family; Region: CCC1_like_1; cd02437 639283011590 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 639283011591 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 639283011592 RNase E interface [polypeptide binding]; other site 639283011593 trimer interface [polypeptide binding]; other site 639283011594 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 639283011595 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 639283011596 RNase E interface [polypeptide binding]; other site 639283011597 trimer interface [polypeptide binding]; other site 639283011598 active site 639283011599 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 639283011600 putative nucleic acid binding region [nucleotide binding]; other site 639283011601 G-X-X-G motif; other site 639283011602 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 639283011603 RNA binding site [nucleotide binding]; other site 639283011604 domain interface; other site 639283011605 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 639283011606 16S/18S rRNA binding site [nucleotide binding]; other site 639283011607 S13e-L30e interaction site [polypeptide binding]; other site 639283011608 25S rRNA binding site [nucleotide binding]; other site 639283011609 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 639283011610 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 639283011611 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 639283011612 RNA binding site [nucleotide binding]; other site 639283011613 active site 639283011614 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 639283011615 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 639283011616 translation initiation factor IF-2; Region: IF-2; TIGR00487 639283011617 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 639283011618 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 639283011619 G1 box; other site 639283011620 putative GEF interaction site [polypeptide binding]; other site 639283011621 GTP/Mg2+ binding site [chemical binding]; other site 639283011622 Switch I region; other site 639283011623 G2 box; other site 639283011624 G3 box; other site 639283011625 Switch II region; other site 639283011626 G4 box; other site 639283011627 G5 box; other site 639283011628 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 639283011629 Translation-initiation factor 2; Region: IF-2; pfam11987 639283011630 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 639283011631 Protein of unknown function (DUF448); Region: DUF448; pfam04296 639283011632 putative RNA binding cleft [nucleotide binding]; other site 639283011633 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 639283011634 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 639283011635 NusA N-terminal domain; Region: NusA_N; pfam08529 639283011636 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 639283011637 RNA binding site [nucleotide binding]; other site 639283011638 homodimer interface [polypeptide binding]; other site 639283011639 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 639283011640 G-X-X-G motif; other site 639283011641 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 639283011642 G-X-X-G motif; other site 639283011643 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 639283011644 ribosome maturation protein RimP; Reviewed; Region: PRK00092 639283011645 Sm and related proteins; Region: Sm_like; cl00259 639283011646 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 639283011647 putative oligomer interface [polypeptide binding]; other site 639283011648 putative RNA binding site [nucleotide binding]; other site 639283011649 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 639283011650 hypothetical protein; Provisional; Region: PRK02237 639283011651 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 639283011652 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 639283011653 substrate binding pocket [chemical binding]; other site 639283011654 chain length determination region; other site 639283011655 substrate-Mg2+ binding site; other site 639283011656 catalytic residues [active] 639283011657 aspartate-rich region 1; other site 639283011658 active site lid residues [active] 639283011659 aspartate-rich region 2; other site 639283011660 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 639283011661 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 639283011662 Methyltransferase domain; Region: Methyltransf_26; pfam13659 639283011663 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 639283011664 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 639283011665 tandem repeat interface [polypeptide binding]; other site 639283011666 oligomer interface [polypeptide binding]; other site 639283011667 active site residues [active] 639283011668 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283011669 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283011670 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283011671 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 639283011672 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 639283011673 Walker A/P-loop; other site 639283011674 ATP binding site [chemical binding]; other site 639283011675 Q-loop/lid; other site 639283011676 ABC transporter signature motif; other site 639283011677 Walker B; other site 639283011678 D-loop; other site 639283011679 H-loop/switch region; other site 639283011680 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 639283011681 FtsX-like permease family; Region: FtsX; pfam02687 639283011682 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 639283011683 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 639283011684 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 639283011685 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 639283011686 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 639283011687 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 639283011688 active site 639283011689 nucleophile elbow; other site 639283011690 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 639283011691 nucleoside/Zn binding site; other site 639283011692 dimer interface [polypeptide binding]; other site 639283011693 catalytic motif [active] 639283011694 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 639283011695 RNA binding surface [nucleotide binding]; other site 639283011696 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 639283011697 pseudouridine synthase; Region: TIGR00093 639283011698 active site 639283011699 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 639283011700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283011701 S-adenosylmethionine binding site [chemical binding]; other site 639283011702 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283011703 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 639283011704 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 639283011705 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 639283011706 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 639283011707 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 639283011708 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 639283011709 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 639283011710 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 639283011711 substrate binding site [chemical binding]; other site 639283011712 active site 639283011713 catalytic residues [active] 639283011714 heterodimer interface [polypeptide binding]; other site 639283011715 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 639283011716 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 639283011717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283011718 catalytic residue [active] 639283011719 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 639283011720 active site 639283011721 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283011722 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 639283011723 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 639283011724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283011725 dimer interface [polypeptide binding]; other site 639283011726 conserved gate region; other site 639283011727 putative PBP binding loops; other site 639283011728 ABC-ATPase subunit interface; other site 639283011729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283011730 dimer interface [polypeptide binding]; other site 639283011731 conserved gate region; other site 639283011732 putative PBP binding loops; other site 639283011733 ABC-ATPase subunit interface; other site 639283011734 ornithine cyclodeaminase; Validated; Region: PRK06141 639283011735 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 639283011736 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 639283011737 IHF dimer interface [polypeptide binding]; other site 639283011738 IHF - DNA interface [nucleotide binding]; other site 639283011739 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 639283011740 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 639283011741 tandem repeat interface [polypeptide binding]; other site 639283011742 oligomer interface [polypeptide binding]; other site 639283011743 active site residues [active] 639283011744 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 639283011745 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 639283011746 trimer interface [polypeptide binding]; other site 639283011747 active site 639283011748 substrate binding site [chemical binding]; other site 639283011749 CoA binding site [chemical binding]; other site 639283011750 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 639283011751 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 639283011752 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283011753 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283011754 active site 639283011755 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 639283011756 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 639283011757 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 639283011758 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 639283011759 active site 639283011760 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 639283011761 dimer interface [polypeptide binding]; other site 639283011762 catalytic residues [active] 639283011763 substrate binding site [chemical binding]; other site 639283011764 Predicted acetyltransferase [General function prediction only]; Region: COG3153 639283011765 Coenzyme A binding pocket [chemical binding]; other site 639283011766 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 639283011767 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 639283011768 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 639283011769 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 639283011770 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 639283011771 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 639283011772 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 639283011773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 639283011774 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 639283011775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 639283011776 Predicted membrane protein [Function unknown]; Region: COG2259 639283011777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 639283011778 binding surface 639283011779 Tetratricopeptide repeat; Region: TPR_16; pfam13432 639283011780 TPR motif; other site 639283011781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283011782 binding surface 639283011783 TPR motif; other site 639283011784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283011785 TPR repeat; Region: TPR_11; pfam13414 639283011786 binding surface 639283011787 TPR motif; other site 639283011788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283011789 binding surface 639283011790 TPR motif; other site 639283011791 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 639283011792 S-adenosylmethionine synthetase; Validated; Region: PRK05250 639283011793 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 639283011794 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 639283011795 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 639283011796 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 639283011797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283011798 non-specific DNA binding site [nucleotide binding]; other site 639283011799 salt bridge; other site 639283011800 sequence-specific DNA binding site [nucleotide binding]; other site 639283011801 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 639283011802 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 639283011803 putative active site [active] 639283011804 catalytic triad [active] 639283011805 putative dimer interface [polypeptide binding]; other site 639283011806 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 639283011807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 639283011808 Transporter associated domain; Region: CorC_HlyC; smart01091 639283011809 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 639283011810 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 639283011811 PhoH-like protein; Region: PhoH; pfam02562 639283011812 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 639283011813 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 639283011814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283011815 FeS/SAM binding site; other site 639283011816 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 639283011817 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 639283011818 putative acyl-acceptor binding pocket; other site 639283011819 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 639283011820 metal binding site 2 [ion binding]; metal-binding site 639283011821 putative DNA binding helix; other site 639283011822 metal binding site 1 [ion binding]; metal-binding site 639283011823 dimer interface [polypeptide binding]; other site 639283011824 structural Zn2+ binding site [ion binding]; other site 639283011825 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 639283011826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283011827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 639283011828 Coenzyme A binding pocket [chemical binding]; other site 639283011829 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 639283011830 Glycoprotease family; Region: Peptidase_M22; pfam00814 639283011831 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 639283011832 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 639283011833 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 639283011834 Ligand Binding Site [chemical binding]; other site 639283011835 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 639283011836 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 639283011837 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 639283011838 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 639283011839 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 639283011840 active site 639283011841 HIGH motif; other site 639283011842 dimer interface [polypeptide binding]; other site 639283011843 KMSKS motif; other site 639283011844 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 639283011845 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 639283011846 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 639283011847 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 639283011848 substrate binding site [chemical binding]; other site 639283011849 ATP binding site [chemical binding]; other site 639283011850 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 639283011851 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 639283011852 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 639283011853 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 639283011854 RNA polymerase sigma factor; Provisional; Region: PRK12511 639283011855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 639283011856 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 639283011857 DNA binding residues [nucleotide binding] 639283011858 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 639283011859 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 639283011860 nucleotide binding site [chemical binding]; other site 639283011861 Low affinity iron permease; Region: Iron_permease; pfam04120 639283011862 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 639283011863 short chain dehydrogenase; Provisional; Region: PRK06701 639283011864 NAD binding site [chemical binding]; other site 639283011865 metal binding site [ion binding]; metal-binding site 639283011866 active site 639283011867 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 639283011868 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 639283011869 dimerization interface [polypeptide binding]; other site 639283011870 metal binding site [ion binding]; metal-binding site 639283011871 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 639283011872 putative catalytic site [active] 639283011873 putative metal binding site [ion binding]; other site 639283011874 putative phosphate binding site [ion binding]; other site 639283011875 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 639283011876 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 639283011877 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 639283011878 putative active site [active] 639283011879 putative active site [active] 639283011880 catalytic site [active] 639283011881 catalytic site [active] 639283011882 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 639283011883 putative active site [active] 639283011884 catalytic site [active] 639283011885 Uncharacterized conserved protein [Function unknown]; Region: COG0398 639283011886 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 639283011887 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 639283011888 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 639283011889 metal binding site [ion binding]; metal-binding site 639283011890 putative dimer interface [polypeptide binding]; other site 639283011891 Major Facilitator Superfamily; Region: MFS_1; pfam07690 639283011892 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 639283011893 transaldolase-like protein; Provisional; Region: PTZ00411 639283011894 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 639283011895 active site 639283011896 dimer interface [polypeptide binding]; other site 639283011897 catalytic residue [active] 639283011898 Chromate transporter; Region: Chromate_transp; pfam02417 639283011899 Chromate transporter; Region: Chromate_transp; pfam02417 639283011900 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 639283011901 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 639283011902 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 639283011903 active site 639283011904 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 639283011905 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 639283011906 putative acyl-acceptor binding pocket; other site 639283011907 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 639283011908 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 639283011909 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 639283011910 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 639283011911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 639283011912 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 639283011913 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 639283011914 generic binding surface II; other site 639283011915 generic binding surface I; other site 639283011916 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 639283011917 dimer interface [polypeptide binding]; other site 639283011918 motif 1; other site 639283011919 active site 639283011920 motif 2; other site 639283011921 motif 3; other site 639283011922 metabolite-proton symporter; Region: 2A0106; TIGR00883 639283011923 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 639283011924 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 639283011925 DALR anticodon binding domain; Region: DALR_1; smart00836 639283011926 Protein of unknown function (DUF3096); Region: DUF3096; pfam11295 639283011927 Predicted membrane protein [Function unknown]; Region: COG2259 639283011928 pyruvate phosphate dikinase; Provisional; Region: PRK09279 639283011929 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 639283011930 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 639283011931 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 639283011932 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 639283011933 MutS domain I; Region: MutS_I; pfam01624 639283011934 MutS domain II; Region: MutS_II; pfam05188 639283011935 MutS domain III; Region: MutS_III; pfam05192 639283011936 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 639283011937 Walker A/P-loop; other site 639283011938 ATP binding site [chemical binding]; other site 639283011939 Q-loop/lid; other site 639283011940 ABC transporter signature motif; other site 639283011941 Walker B; other site 639283011942 D-loop; other site 639283011943 H-loop/switch region; other site 639283011944 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 639283011945 Chromate transporter; Region: Chromate_transp; pfam02417 639283011946 Chromate transporter; Region: Chromate_transp; pfam02417 639283011947 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 639283011948 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 639283011949 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 639283011950 feedback inhibition sensing region; other site 639283011951 homohexameric interface [polypeptide binding]; other site 639283011952 nucleotide binding site [chemical binding]; other site 639283011953 N-acetyl-L-glutamate binding site [chemical binding]; other site 639283011954 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 639283011955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 639283011956 motif II; other site 639283011957 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 639283011958 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 639283011959 trimer interface [polypeptide binding]; other site 639283011960 active site 639283011961 substrate binding site [chemical binding]; other site 639283011962 CoA binding site [chemical binding]; other site 639283011963 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 639283011964 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 639283011965 metal binding site [ion binding]; metal-binding site 639283011966 dimer interface [polypeptide binding]; other site 639283011967 Porin subfamily; Region: Porin_2; pfam02530 639283011968 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 639283011969 nudix motif; other site 639283011970 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 639283011971 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 639283011972 Uncharacterized conserved protein [Function unknown]; Region: COG5470 639283011973 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 639283011974 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 639283011975 active site 639283011976 dimer interface [polypeptide binding]; other site 639283011977 Predicted flavoprotein [General function prediction only]; Region: COG0431 639283011978 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 639283011979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283011980 S-adenosylmethionine binding site [chemical binding]; other site 639283011981 chaperone protein DnaJ; Provisional; Region: PRK10767 639283011982 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 639283011983 HSP70 interaction site [polypeptide binding]; other site 639283011984 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 639283011985 substrate binding site [polypeptide binding]; other site 639283011986 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 639283011987 Zn binding sites [ion binding]; other site 639283011988 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 639283011989 dimer interface [polypeptide binding]; other site 639283011990 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 639283011991 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 639283011992 nucleotide binding site [chemical binding]; other site 639283011993 NEF interaction site [polypeptide binding]; other site 639283011994 SBD interface [polypeptide binding]; other site 639283011995 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 639283011996 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 639283011997 AP (apurinic/apyrimidinic) site pocket; other site 639283011998 DNA interaction; other site 639283011999 Metal-binding active site; metal-binding site 639283012000 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 639283012001 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 639283012002 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 639283012003 C-terminal domain interface [polypeptide binding]; other site 639283012004 GSH binding site (G-site) [chemical binding]; other site 639283012005 dimer interface [polypeptide binding]; other site 639283012006 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 639283012007 N-terminal domain interface [polypeptide binding]; other site 639283012008 dimer interface [polypeptide binding]; other site 639283012009 substrate binding pocket (H-site) [chemical binding]; other site 639283012010 epoxyqueuosine reductase; Region: TIGR00276 639283012011 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 639283012012 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 639283012013 putative NAD(P) binding site [chemical binding]; other site 639283012014 NADH(P)-binding; Region: NAD_binding_10; pfam13460 639283012015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283012016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283012017 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 639283012018 K+ potassium transporter; Region: K_trans; pfam02705 639283012019 potassium uptake protein; Region: kup; TIGR00794 639283012020 Predicted integral membrane protein [Function unknown]; Region: COG0392 639283012021 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 639283012022 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 639283012023 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 639283012024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283012025 dimer interface [polypeptide binding]; other site 639283012026 phosphorylation site [posttranslational modification] 639283012027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283012028 ATP binding site [chemical binding]; other site 639283012029 Mg2+ binding site [ion binding]; other site 639283012030 G-X-G motif; other site 639283012031 PBP superfamily domain; Region: PBP_like_2; cl17296 639283012032 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 639283012033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012034 dimer interface [polypeptide binding]; other site 639283012035 conserved gate region; other site 639283012036 putative PBP binding loops; other site 639283012037 ABC-ATPase subunit interface; other site 639283012038 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 639283012039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012040 dimer interface [polypeptide binding]; other site 639283012041 conserved gate region; other site 639283012042 putative PBP binding loops; other site 639283012043 ABC-ATPase subunit interface; other site 639283012044 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 639283012045 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 639283012046 Walker A/P-loop; other site 639283012047 ATP binding site [chemical binding]; other site 639283012048 Q-loop/lid; other site 639283012049 ABC transporter signature motif; other site 639283012050 Walker B; other site 639283012051 D-loop; other site 639283012052 H-loop/switch region; other site 639283012053 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 639283012054 PhoU domain; Region: PhoU; pfam01895 639283012055 PhoU domain; Region: PhoU; pfam01895 639283012056 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 639283012057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283012058 active site 639283012059 phosphorylation site [posttranslational modification] 639283012060 intermolecular recognition site; other site 639283012061 dimerization interface [polypeptide binding]; other site 639283012062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283012063 DNA binding site [nucleotide binding] 639283012064 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 639283012065 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 639283012066 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 639283012067 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 639283012068 DNA binding site [nucleotide binding] 639283012069 active site 639283012070 short chain dehydrogenase; Provisional; Region: PRK07478 639283012071 classical (c) SDRs; Region: SDR_c; cd05233 639283012072 NAD(P) binding site [chemical binding]; other site 639283012073 active site 639283012074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283012075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283012076 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 639283012077 putative effector binding pocket; other site 639283012078 dimerization interface [polypeptide binding]; other site 639283012079 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 639283012080 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 639283012081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283012082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283012083 ATP binding site [chemical binding]; other site 639283012084 Mg2+ binding site [ion binding]; other site 639283012085 G-X-G motif; other site 639283012086 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 639283012087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283012088 active site 639283012089 phosphorylation site [posttranslational modification] 639283012090 intermolecular recognition site; other site 639283012091 dimerization interface [polypeptide binding]; other site 639283012092 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 639283012093 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 639283012094 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 639283012095 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 639283012096 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 639283012097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283012098 motif II; other site 639283012099 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 639283012100 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 639283012101 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 639283012102 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 639283012103 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 639283012104 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 639283012105 active site 639283012106 catalytic tetrad [active] 639283012107 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 639283012108 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 639283012109 inhibitor-cofactor binding pocket; inhibition site 639283012110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283012111 catalytic residue [active] 639283012112 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 639283012113 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 639283012114 active site 639283012115 ATP binding site [chemical binding]; other site 639283012116 Isochorismatase family; Region: Isochorismatase; pfam00857 639283012117 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 639283012118 catalytic triad [active] 639283012119 conserved cis-peptide bond; other site 639283012120 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 639283012121 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 639283012122 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 639283012123 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 639283012124 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283012125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012126 dimer interface [polypeptide binding]; other site 639283012127 conserved gate region; other site 639283012128 putative PBP binding loops; other site 639283012129 ABC-ATPase subunit interface; other site 639283012130 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283012131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012132 dimer interface [polypeptide binding]; other site 639283012133 conserved gate region; other site 639283012134 putative PBP binding loops; other site 639283012135 ABC-ATPase subunit interface; other site 639283012136 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283012137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283012138 Walker A/P-loop; other site 639283012139 ATP binding site [chemical binding]; other site 639283012140 Q-loop/lid; other site 639283012141 ABC transporter signature motif; other site 639283012142 Walker B; other site 639283012143 D-loop; other site 639283012144 H-loop/switch region; other site 639283012145 TOBE domain; Region: TOBE_2; pfam08402 639283012146 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 639283012147 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 639283012148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283012149 NAD(P) binding site [chemical binding]; other site 639283012150 active site 639283012151 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 639283012152 tartrate dehydrogenase; Region: TTC; TIGR02089 639283012153 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 639283012154 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 639283012155 phosphate binding site [ion binding]; other site 639283012156 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283012157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283012158 DNA-binding site [nucleotide binding]; DNA binding site 639283012159 FCD domain; Region: FCD; pfam07729 639283012160 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 639283012161 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 639283012162 putative ligand binding site [chemical binding]; other site 639283012163 NAD binding site [chemical binding]; other site 639283012164 catalytic site [active] 639283012165 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 639283012166 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283012167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283012168 DNA-binding site [nucleotide binding]; DNA binding site 639283012169 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 639283012170 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 639283012171 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 639283012172 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 639283012173 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 639283012174 active site 639283012175 intersubunit interface [polypeptide binding]; other site 639283012176 catalytic residue [active] 639283012177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 639283012178 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 639283012179 NAD binding site [chemical binding]; other site 639283012180 homotetramer interface [polypeptide binding]; other site 639283012181 homodimer interface [polypeptide binding]; other site 639283012182 active site 639283012183 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 639283012184 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 639283012185 active site pocket [active] 639283012186 Porin subfamily; Region: Porin_2; pfam02530 639283012187 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 639283012188 putative aldolase; Validated; Region: PRK08130 639283012189 intersubunit interface [polypeptide binding]; other site 639283012190 active site 639283012191 Zn2+ binding site [ion binding]; other site 639283012192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 639283012193 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 639283012194 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 639283012195 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 639283012196 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283012197 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283012198 Walker A/P-loop; other site 639283012199 ATP binding site [chemical binding]; other site 639283012200 Q-loop/lid; other site 639283012201 ABC transporter signature motif; other site 639283012202 Walker B; other site 639283012203 D-loop; other site 639283012204 H-loop/switch region; other site 639283012205 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283012206 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283012207 TM-ABC transporter signature motif; other site 639283012208 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283012209 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283012210 Walker A/P-loop; other site 639283012211 ATP binding site [chemical binding]; other site 639283012212 Q-loop/lid; other site 639283012213 ABC transporter signature motif; other site 639283012214 Walker B; other site 639283012215 D-loop; other site 639283012216 H-loop/switch region; other site 639283012217 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283012218 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283012219 TM-ABC transporter signature motif; other site 639283012220 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283012221 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 639283012222 ligand binding site [chemical binding]; other site 639283012223 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283012224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283012225 DNA-binding site [nucleotide binding]; DNA binding site 639283012226 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 639283012227 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 639283012228 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 639283012229 putative NAD(P) binding site [chemical binding]; other site 639283012230 active site 639283012231 putative substrate binding site [chemical binding]; other site 639283012232 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 639283012233 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 639283012234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283012235 NAD(P) binding site [chemical binding]; other site 639283012236 active site 639283012237 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 639283012238 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 639283012239 active site pocket [active] 639283012240 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283012241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012242 dimer interface [polypeptide binding]; other site 639283012243 conserved gate region; other site 639283012244 putative PBP binding loops; other site 639283012245 ABC-ATPase subunit interface; other site 639283012246 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283012247 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283012248 substrate binding pocket [chemical binding]; other site 639283012249 membrane-bound complex binding site; other site 639283012250 hinge residues; other site 639283012251 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 639283012252 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 639283012253 active site pocket [active] 639283012254 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283012255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283012256 DNA-binding site [nucleotide binding]; DNA binding site 639283012257 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 639283012258 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 639283012259 enoyl-CoA hydratase; Provisional; Region: PRK06495 639283012260 substrate binding site [chemical binding]; other site 639283012261 oxyanion hole (OAH) forming residues; other site 639283012262 trimer interface [polypeptide binding]; other site 639283012263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283012264 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283012265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 639283012266 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 639283012267 hypothetical protein; Provisional; Region: PRK06184 639283012268 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 639283012269 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 639283012270 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 639283012271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012272 dimer interface [polypeptide binding]; other site 639283012273 conserved gate region; other site 639283012274 putative PBP binding loops; other site 639283012275 ABC-ATPase subunit interface; other site 639283012276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283012277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012278 dimer interface [polypeptide binding]; other site 639283012279 conserved gate region; other site 639283012280 putative PBP binding loops; other site 639283012281 ABC-ATPase subunit interface; other site 639283012282 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 639283012283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283012284 Walker A/P-loop; other site 639283012285 ATP binding site [chemical binding]; other site 639283012286 Q-loop/lid; other site 639283012287 ABC transporter signature motif; other site 639283012288 Walker B; other site 639283012289 D-loop; other site 639283012290 H-loop/switch region; other site 639283012291 TOBE domain; Region: TOBE_2; pfam08402 639283012292 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 639283012293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283012294 Walker A/P-loop; other site 639283012295 ATP binding site [chemical binding]; other site 639283012296 Q-loop/lid; other site 639283012297 ABC transporter signature motif; other site 639283012298 Walker B; other site 639283012299 D-loop; other site 639283012300 H-loop/switch region; other site 639283012301 TOBE domain; Region: TOBE_2; pfam08402 639283012302 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 639283012303 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 639283012304 DAK2 domain; Region: Dak2; pfam02734 639283012305 DAK2 domain; Region: Dak2; cl03685 639283012306 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 639283012307 active site 639283012308 active pocket/dimerization site; other site 639283012309 phosphorylation site [posttranslational modification] 639283012310 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 639283012311 dimerization domain swap beta strand [polypeptide binding]; other site 639283012312 regulatory protein interface [polypeptide binding]; other site 639283012313 active site 639283012314 regulatory phosphorylation site [posttranslational modification]; other site 639283012315 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 639283012316 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 639283012317 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 639283012318 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 639283012319 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 639283012320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283012321 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 639283012322 putative active site [active] 639283012323 heme pocket [chemical binding]; other site 639283012324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 639283012325 putative active site [active] 639283012326 heme pocket [chemical binding]; other site 639283012327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283012328 dimer interface [polypeptide binding]; other site 639283012329 phosphorylation site [posttranslational modification] 639283012330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283012331 ATP binding site [chemical binding]; other site 639283012332 Mg2+ binding site [ion binding]; other site 639283012333 G-X-G motif; other site 639283012334 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 639283012335 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 639283012336 putative active site [active] 639283012337 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 639283012338 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 639283012339 CoA-transferase family III; Region: CoA_transf_3; pfam02515 639283012340 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 639283012341 Amidase; Region: Amidase; pfam01425 639283012342 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283012343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283012344 Walker A/P-loop; other site 639283012345 ATP binding site [chemical binding]; other site 639283012346 Q-loop/lid; other site 639283012347 ABC transporter signature motif; other site 639283012348 Walker B; other site 639283012349 D-loop; other site 639283012350 H-loop/switch region; other site 639283012351 TOBE domain; Region: TOBE_2; pfam08402 639283012352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012353 dimer interface [polypeptide binding]; other site 639283012354 conserved gate region; other site 639283012355 ABC-ATPase subunit interface; other site 639283012356 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283012357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012358 dimer interface [polypeptide binding]; other site 639283012359 conserved gate region; other site 639283012360 putative PBP binding loops; other site 639283012361 ABC-ATPase subunit interface; other site 639283012362 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 639283012363 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 639283012364 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 639283012365 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 639283012366 active site 639283012367 DNA binding site [nucleotide binding] 639283012368 Int/Topo IB signature motif; other site 639283012369 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 639283012370 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 639283012371 Isochorismatase family; Region: Isochorismatase; pfam00857 639283012372 catalytic triad [active] 639283012373 conserved cis-peptide bond; other site 639283012374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 639283012375 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 639283012376 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 639283012377 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 639283012378 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283012379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012380 dimer interface [polypeptide binding]; other site 639283012381 conserved gate region; other site 639283012382 putative PBP binding loops; other site 639283012383 ABC-ATPase subunit interface; other site 639283012384 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283012385 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283012386 Walker A/P-loop; other site 639283012387 ATP binding site [chemical binding]; other site 639283012388 Q-loop/lid; other site 639283012389 ABC transporter signature motif; other site 639283012390 Walker B; other site 639283012391 D-loop; other site 639283012392 H-loop/switch region; other site 639283012393 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 639283012394 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 639283012395 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 639283012396 Transposase; Region: HTH_Tnp_1; cl17663 639283012397 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283012398 Periplasmic binding protein domain; Region: Peripla_BP_5; pfam13433 639283012399 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283012400 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283012401 TM-ABC transporter signature motif; other site 639283012402 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283012403 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283012404 TM-ABC transporter signature motif; other site 639283012405 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 639283012406 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283012407 Walker A/P-loop; other site 639283012408 ATP binding site [chemical binding]; other site 639283012409 Q-loop/lid; other site 639283012410 ABC transporter signature motif; other site 639283012411 Walker B; other site 639283012412 D-loop; other site 639283012413 H-loop/switch region; other site 639283012414 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 639283012415 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283012416 Walker A/P-loop; other site 639283012417 ATP binding site [chemical binding]; other site 639283012418 Q-loop/lid; other site 639283012419 ABC transporter signature motif; other site 639283012420 Walker B; other site 639283012421 D-loop; other site 639283012422 H-loop/switch region; other site 639283012423 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 639283012424 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283012425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283012426 DNA-binding site [nucleotide binding]; DNA binding site 639283012427 FCD domain; Region: FCD; pfam07729 639283012428 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 639283012429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 639283012430 dimerization interface [polypeptide binding]; other site 639283012431 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283012432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012433 dimer interface [polypeptide binding]; other site 639283012434 conserved gate region; other site 639283012435 putative PBP binding loops; other site 639283012436 ABC-ATPase subunit interface; other site 639283012437 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283012438 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283012439 Walker A/P-loop; other site 639283012440 ATP binding site [chemical binding]; other site 639283012441 Q-loop/lid; other site 639283012442 ABC transporter signature motif; other site 639283012443 Walker B; other site 639283012444 D-loop; other site 639283012445 H-loop/switch region; other site 639283012446 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283012447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 639283012448 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 639283012449 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 639283012450 Cupin domain; Region: Cupin_2; cl17218 639283012451 Fusaric acid resistance protein family; Region: FUSC; pfam04632 639283012452 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 639283012453 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 639283012454 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 639283012455 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 639283012456 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283012457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283012458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283012459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 639283012460 dimerization interface [polypeptide binding]; other site 639283012461 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 639283012462 FAD binding domain; Region: FAD_binding_4; pfam01565 639283012463 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 639283012464 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 639283012465 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 639283012466 active site 639283012467 non-prolyl cis peptide bond; other site 639283012468 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 639283012469 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 639283012470 putative ligand binding site [chemical binding]; other site 639283012471 NAD binding site [chemical binding]; other site 639283012472 dimerization interface [polypeptide binding]; other site 639283012473 catalytic site [active] 639283012474 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 639283012475 agmatinase; Region: agmatinase; TIGR01230 639283012476 oligomer interface [polypeptide binding]; other site 639283012477 putative active site [active] 639283012478 Mn binding site [ion binding]; other site 639283012479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012480 putative PBP binding loops; other site 639283012481 dimer interface [polypeptide binding]; other site 639283012482 ABC-ATPase subunit interface; other site 639283012483 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 639283012484 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 639283012485 Walker A/P-loop; other site 639283012486 ATP binding site [chemical binding]; other site 639283012487 Q-loop/lid; other site 639283012488 ABC transporter signature motif; other site 639283012489 Walker B; other site 639283012490 D-loop; other site 639283012491 H-loop/switch region; other site 639283012492 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 639283012493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 639283012494 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 639283012495 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283012496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012497 dimer interface [polypeptide binding]; other site 639283012498 conserved gate region; other site 639283012499 putative PBP binding loops; other site 639283012500 ABC-ATPase subunit interface; other site 639283012501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012502 dimer interface [polypeptide binding]; other site 639283012503 conserved gate region; other site 639283012504 putative PBP binding loops; other site 639283012505 ABC-ATPase subunit interface; other site 639283012506 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 639283012507 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 639283012508 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283012509 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 639283012510 Walker A/P-loop; other site 639283012511 ATP binding site [chemical binding]; other site 639283012512 Q-loop/lid; other site 639283012513 ABC transporter signature motif; other site 639283012514 Walker B; other site 639283012515 D-loop; other site 639283012516 H-loop/switch region; other site 639283012517 TOBE domain; Region: TOBE_2; pfam08402 639283012518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283012519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283012520 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 639283012521 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 639283012522 dimer interface [polypeptide binding]; other site 639283012523 active site 639283012524 heme binding site [chemical binding]; other site 639283012525 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 639283012526 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 639283012527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283012528 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 639283012529 dimerization interface [polypeptide binding]; other site 639283012530 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283012531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283012532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283012533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 639283012534 dimerization interface [polypeptide binding]; other site 639283012535 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 639283012536 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 639283012537 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 639283012538 Flavin Reductases; Region: FlaRed; cl00801 639283012539 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 639283012540 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283012541 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 639283012542 Walker A/P-loop; other site 639283012543 ATP binding site [chemical binding]; other site 639283012544 Q-loop/lid; other site 639283012545 ABC transporter signature motif; other site 639283012546 Walker B; other site 639283012547 D-loop; other site 639283012548 H-loop/switch region; other site 639283012549 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283012550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012551 dimer interface [polypeptide binding]; other site 639283012552 conserved gate region; other site 639283012553 putative PBP binding loops; other site 639283012554 ABC-ATPase subunit interface; other site 639283012555 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283012556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012557 dimer interface [polypeptide binding]; other site 639283012558 conserved gate region; other site 639283012559 putative PBP binding loops; other site 639283012560 ABC-ATPase subunit interface; other site 639283012561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283012562 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283012563 substrate binding pocket [chemical binding]; other site 639283012564 membrane-bound complex binding site; other site 639283012565 hinge residues; other site 639283012566 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 639283012567 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 639283012568 active site 639283012569 non-prolyl cis peptide bond; other site 639283012570 phenylhydantoinase; Validated; Region: PRK08323 639283012571 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 639283012572 tetramer interface [polypeptide binding]; other site 639283012573 active site 639283012574 allantoate amidohydrolase; Reviewed; Region: PRK12893 639283012575 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 639283012576 active site 639283012577 metal binding site [ion binding]; metal-binding site 639283012578 dimer interface [polypeptide binding]; other site 639283012579 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 639283012580 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 639283012581 active site 639283012582 catalytic site [active] 639283012583 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 639283012584 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 639283012585 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 639283012586 catalytic site [active] 639283012587 active site 639283012588 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 639283012589 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 639283012590 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 639283012591 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 639283012592 active site 639283012593 catalytic site [active] 639283012594 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 639283012595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283012596 active site 639283012597 phosphorylation site [posttranslational modification] 639283012598 intermolecular recognition site; other site 639283012599 dimerization interface [polypeptide binding]; other site 639283012600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 639283012601 DNA binding residues [nucleotide binding] 639283012602 dimerization interface [polypeptide binding]; other site 639283012603 HAMP domain; Region: HAMP; pfam00672 639283012604 dimerization interface [polypeptide binding]; other site 639283012605 Histidine kinase; Region: HisKA_3; pfam07730 639283012606 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 639283012607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283012608 ATP binding site [chemical binding]; other site 639283012609 Mg2+ binding site [ion binding]; other site 639283012610 G-X-G motif; other site 639283012611 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 639283012612 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 639283012613 Trp docking motif [polypeptide binding]; other site 639283012614 dimer interface [polypeptide binding]; other site 639283012615 active site 639283012616 small subunit binding site [polypeptide binding]; other site 639283012617 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 639283012618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283012619 substrate binding pocket [chemical binding]; other site 639283012620 membrane-bound complex binding site; other site 639283012621 hinge residues; other site 639283012622 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 639283012623 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 639283012624 MoxR-like ATPases [General function prediction only]; Region: COG0714 639283012625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283012626 Walker A motif; other site 639283012627 ATP binding site [chemical binding]; other site 639283012628 Walker B motif; other site 639283012629 arginine finger; other site 639283012630 Protein of unknown function DUF58; Region: DUF58; pfam01882 639283012631 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 639283012632 metal ion-dependent adhesion site (MIDAS); other site 639283012633 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 639283012634 metal ion-dependent adhesion site (MIDAS); other site 639283012635 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 639283012636 putative hydrophobic ligand binding site [chemical binding]; other site 639283012637 protein interface [polypeptide binding]; other site 639283012638 gate; other site 639283012639 PQQ-like domain; Region: PQQ_2; pfam13360 639283012640 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283012641 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283012642 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283012643 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 639283012644 Predicted integral membrane protein [Function unknown]; Region: COG5616 639283012645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 639283012646 TPR motif; other site 639283012647 binding surface 639283012648 arginine deiminase; Provisional; Region: PRK01388 639283012649 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 639283012650 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 639283012651 putative substrate binding site [chemical binding]; other site 639283012652 nucleotide binding site [chemical binding]; other site 639283012653 nucleotide binding site [chemical binding]; other site 639283012654 homodimer interface [polypeptide binding]; other site 639283012655 ornithine carbamoyltransferase; Validated; Region: PRK02102 639283012656 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 639283012657 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 639283012658 arginine:agmatin antiporter; Provisional; Region: PRK10644 639283012659 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 639283012660 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 639283012661 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 639283012662 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 639283012663 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 639283012664 phosphate acetyltransferase; Provisional; Region: PRK11890 639283012665 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 639283012666 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 639283012667 NAD binding site [chemical binding]; other site 639283012668 homotetramer interface [polypeptide binding]; other site 639283012669 homodimer interface [polypeptide binding]; other site 639283012670 substrate binding site [chemical binding]; other site 639283012671 active site 639283012672 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 639283012673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283012674 DNA-binding site [nucleotide binding]; DNA binding site 639283012675 UTRA domain; Region: UTRA; cl17743 639283012676 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 639283012677 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 639283012678 ligand binding site [chemical binding]; other site 639283012679 homodimer interface [polypeptide binding]; other site 639283012680 NAD(P) binding site [chemical binding]; other site 639283012681 trimer interface B [polypeptide binding]; other site 639283012682 trimer interface A [polypeptide binding]; other site 639283012683 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 639283012684 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 639283012685 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 639283012686 FOG: CBS domain [General function prediction only]; Region: COG0517 639283012687 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 639283012688 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 639283012689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283012690 catalytic residue [active] 639283012691 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 639283012692 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 639283012693 ligand binding site [chemical binding]; other site 639283012694 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 639283012695 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 639283012696 TM-ABC transporter signature motif; other site 639283012697 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 639283012698 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 639283012699 TM-ABC transporter signature motif; other site 639283012700 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 639283012701 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 639283012702 Walker A/P-loop; other site 639283012703 ATP binding site [chemical binding]; other site 639283012704 Q-loop/lid; other site 639283012705 ABC transporter signature motif; other site 639283012706 Walker B; other site 639283012707 D-loop; other site 639283012708 H-loop/switch region; other site 639283012709 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 639283012710 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 639283012711 Walker A/P-loop; other site 639283012712 ATP binding site [chemical binding]; other site 639283012713 Q-loop/lid; other site 639283012714 ABC transporter signature motif; other site 639283012715 Walker B; other site 639283012716 D-loop; other site 639283012717 H-loop/switch region; other site 639283012718 acetylornithine deacetylase; Validated; Region: PRK06915 639283012719 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 639283012720 metal binding site [ion binding]; metal-binding site 639283012721 dimer interface [polypeptide binding]; other site 639283012722 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 639283012723 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 639283012724 Coenzyme A transferase; Region: CoA_trans; cl17247 639283012725 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 639283012726 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 639283012727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 639283012728 FO synthase; Reviewed; Region: fbiC; PRK09234 639283012729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283012730 FeS/SAM binding site; other site 639283012731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283012732 FeS/SAM binding site; other site 639283012733 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 639283012734 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 639283012735 dimer interface [polypeptide binding]; other site 639283012736 substrate binding site [chemical binding]; other site 639283012737 phosphate binding site [ion binding]; other site 639283012738 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 639283012739 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 639283012740 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 639283012741 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 639283012742 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 639283012743 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 639283012744 catalytic loop [active] 639283012745 iron binding site [ion binding]; other site 639283012746 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 639283012747 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 639283012748 putative hydrophobic ligand binding site [chemical binding]; other site 639283012749 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 639283012750 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 639283012751 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 639283012752 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 639283012753 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 639283012754 putative active site [active] 639283012755 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 639283012756 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 639283012757 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 639283012758 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 639283012759 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 639283012760 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 639283012761 Subunit I/III interface [polypeptide binding]; other site 639283012762 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 639283012763 Subunit I/III interface [polypeptide binding]; other site 639283012764 Predicted small integral membrane protein [Function unknown]; Region: COG5605 639283012765 transcriptional regulator; Provisional; Region: PRK10632 639283012766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283012767 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 639283012768 putative effector binding pocket; other site 639283012769 putative dimerization interface [polypeptide binding]; other site 639283012770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 639283012771 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 639283012772 acetylornithine deacetylase; Provisional; Region: PRK07522 639283012773 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 639283012774 metal binding site [ion binding]; metal-binding site 639283012775 putative dimer interface [polypeptide binding]; other site 639283012776 agmatinase; Region: agmatinase; TIGR01230 639283012777 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 639283012778 oligomer interface [polypeptide binding]; other site 639283012779 active site 639283012780 Mn binding site [ion binding]; other site 639283012781 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 639283012782 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 639283012783 Walker A/P-loop; other site 639283012784 ATP binding site [chemical binding]; other site 639283012785 Q-loop/lid; other site 639283012786 ABC transporter signature motif; other site 639283012787 Walker B; other site 639283012788 D-loop; other site 639283012789 H-loop/switch region; other site 639283012790 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283012791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012792 dimer interface [polypeptide binding]; other site 639283012793 conserved gate region; other site 639283012794 putative PBP binding loops; other site 639283012795 ABC-ATPase subunit interface; other site 639283012796 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 639283012797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012798 dimer interface [polypeptide binding]; other site 639283012799 conserved gate region; other site 639283012800 putative PBP binding loops; other site 639283012801 ABC-ATPase subunit interface; other site 639283012802 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 639283012803 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 639283012804 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283012805 substrate binding pocket [chemical binding]; other site 639283012806 membrane-bound complex binding site; other site 639283012807 hinge residues; other site 639283012808 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 639283012809 homotrimer interaction site [polypeptide binding]; other site 639283012810 putative active site [active] 639283012811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283012812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283012813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 639283012814 dimerization interface [polypeptide binding]; other site 639283012815 Protein of unknown function (DUF763); Region: DUF763; cl00620 639283012816 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 639283012817 Transcriptional regulators [Transcription]; Region: FadR; COG2186 639283012818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283012819 DNA-binding site [nucleotide binding]; DNA binding site 639283012820 FCD domain; Region: FCD; pfam07729 639283012821 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 639283012822 active site 639283012823 catalytic site [active] 639283012824 Zn binding site [ion binding]; other site 639283012825 tetramer interface [polypeptide binding]; other site 639283012826 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 639283012827 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 639283012828 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 639283012829 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 639283012830 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 639283012831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283012832 NAD(P) binding site [chemical binding]; other site 639283012833 active site 639283012834 phenylhydantoinase; Validated; Region: PRK08323 639283012835 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 639283012836 tetramer interface [polypeptide binding]; other site 639283012837 active site 639283012838 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 639283012839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 639283012840 NAD(P) binding site [chemical binding]; other site 639283012841 active site 639283012842 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 639283012843 extended (e) SDRs; Region: SDR_e; cd08946 639283012844 NAD(P) binding site [chemical binding]; other site 639283012845 active site 639283012846 substrate binding site [chemical binding]; other site 639283012847 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 639283012848 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 639283012849 Walker A/P-loop; other site 639283012850 ATP binding site [chemical binding]; other site 639283012851 Q-loop/lid; other site 639283012852 ABC transporter signature motif; other site 639283012853 Walker B; other site 639283012854 D-loop; other site 639283012855 H-loop/switch region; other site 639283012856 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 639283012857 Walker A/P-loop; other site 639283012858 ATP binding site [chemical binding]; other site 639283012859 Q-loop/lid; other site 639283012860 ABC transporter signature motif; other site 639283012861 Walker B; other site 639283012862 D-loop; other site 639283012863 H-loop/switch region; other site 639283012864 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 639283012865 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 639283012866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012867 dimer interface [polypeptide binding]; other site 639283012868 conserved gate region; other site 639283012869 putative PBP binding loops; other site 639283012870 ABC-ATPase subunit interface; other site 639283012871 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 639283012872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 639283012873 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 639283012874 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 639283012875 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283012876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283012877 DNA-binding site [nucleotide binding]; DNA binding site 639283012878 FCD domain; Region: FCD; pfam07729 639283012879 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 639283012880 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 639283012881 substrate binding pocket [chemical binding]; other site 639283012882 membrane-bound complex binding site; other site 639283012883 hinge residues; other site 639283012884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012885 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 639283012886 dimer interface [polypeptide binding]; other site 639283012887 conserved gate region; other site 639283012888 putative PBP binding loops; other site 639283012889 ABC-ATPase subunit interface; other site 639283012890 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 639283012891 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 639283012892 Walker A/P-loop; other site 639283012893 ATP binding site [chemical binding]; other site 639283012894 Q-loop/lid; other site 639283012895 ABC transporter signature motif; other site 639283012896 Walker B; other site 639283012897 D-loop; other site 639283012898 H-loop/switch region; other site 639283012899 Predicted amidohydrolase [General function prediction only]; Region: COG0388 639283012900 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 639283012901 active site 639283012902 catalytic triad [active] 639283012903 dimer interface [polypeptide binding]; other site 639283012904 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 639283012905 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 639283012906 active site 639283012907 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 639283012908 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 639283012909 NAD(P) binding site [chemical binding]; other site 639283012910 catalytic residues [active] 639283012911 catalytic residues [active] 639283012912 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 639283012913 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 639283012914 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 639283012915 DctM-like transporters; Region: DctM; pfam06808 639283012916 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 639283012917 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 639283012918 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 639283012919 catalytic Zn binding site [ion binding]; other site 639283012920 structural Zn binding site [ion binding]; other site 639283012921 tetramer interface [polypeptide binding]; other site 639283012922 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 639283012923 CoA-transferase family III; Region: CoA_transf_3; pfam02515 639283012924 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 639283012925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283012926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283012927 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 639283012928 putative dimerization interface [polypeptide binding]; other site 639283012929 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 639283012930 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 639283012931 dimerization interface [polypeptide binding]; other site 639283012932 putative active cleft [active] 639283012933 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 639283012934 galactarate dehydratase; Region: galactar-dH20; TIGR03248 639283012935 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 639283012936 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283012937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283012938 DNA-binding site [nucleotide binding]; DNA binding site 639283012939 FCD domain; Region: FCD; pfam07729 639283012940 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 639283012941 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 639283012942 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 639283012943 mannonate dehydratase; Provisional; Region: PRK03906 639283012944 mannonate dehydratase; Region: uxuA; TIGR00695 639283012945 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 639283012946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012947 dimer interface [polypeptide binding]; other site 639283012948 conserved gate region; other site 639283012949 putative PBP binding loops; other site 639283012950 ABC-ATPase subunit interface; other site 639283012951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283012952 dimer interface [polypeptide binding]; other site 639283012953 putative PBP binding loops; other site 639283012954 ABC-ATPase subunit interface; other site 639283012955 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 639283012956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283012957 Walker A/P-loop; other site 639283012958 ATP binding site [chemical binding]; other site 639283012959 Q-loop/lid; other site 639283012960 ABC transporter signature motif; other site 639283012961 Walker B; other site 639283012962 D-loop; other site 639283012963 H-loop/switch region; other site 639283012964 TOBE domain; Region: TOBE_2; pfam08402 639283012965 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 639283012966 hypothetical protein; Provisional; Region: PRK11622 639283012967 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 639283012968 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 639283012969 active site 639283012970 trimer interface [polypeptide binding]; other site 639283012971 allosteric site; other site 639283012972 active site lid [active] 639283012973 hexamer (dimer of trimers) interface [polypeptide binding]; other site 639283012974 Transcriptional regulators [Transcription]; Region: PurR; COG1609 639283012975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 639283012976 DNA binding site [nucleotide binding] 639283012977 domain linker motif; other site 639283012978 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 639283012979 dimerization interface [polypeptide binding]; other site 639283012980 ligand binding site [chemical binding]; other site 639283012981 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 639283012982 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 639283012983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283012984 dimer interface [polypeptide binding]; other site 639283012985 phosphorylation site [posttranslational modification] 639283012986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283012987 ATP binding site [chemical binding]; other site 639283012988 Mg2+ binding site [ion binding]; other site 639283012989 G-X-G motif; other site 639283012990 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 639283012991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283012992 active site 639283012993 phosphorylation site [posttranslational modification] 639283012994 intermolecular recognition site; other site 639283012995 dimerization interface [polypeptide binding]; other site 639283012996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283012997 Walker A motif; other site 639283012998 ATP binding site [chemical binding]; other site 639283012999 Walker B motif; other site 639283013000 arginine finger; other site 639283013001 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 639283013002 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 639283013003 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 639283013004 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 639283013005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283013006 dimer interface [polypeptide binding]; other site 639283013007 conserved gate region; other site 639283013008 putative PBP binding loops; other site 639283013009 ABC-ATPase subunit interface; other site 639283013010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283013011 dimer interface [polypeptide binding]; other site 639283013012 conserved gate region; other site 639283013013 putative PBP binding loops; other site 639283013014 ABC-ATPase subunit interface; other site 639283013015 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 639283013016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 639283013017 Walker A/P-loop; other site 639283013018 ATP binding site [chemical binding]; other site 639283013019 Q-loop/lid; other site 639283013020 ABC transporter signature motif; other site 639283013021 Walker B; other site 639283013022 D-loop; other site 639283013023 H-loop/switch region; other site 639283013024 TOBE domain; Region: TOBE_2; pfam08402 639283013025 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 639283013026 nudix motif; other site 639283013027 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 639283013028 Autotransporter beta-domain; Region: Autotransporter; pfam03797 639283013029 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 639283013030 ParB-like nuclease domain; Region: ParBc; pfam02195 639283013031 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 639283013032 DNA methylase; Region: N6_N4_Mtase; pfam01555 639283013033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 639283013034 Terminase-like family; Region: Terminase_6; pfam03237 639283013035 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 639283013036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 639283013037 sequence-specific DNA binding site [nucleotide binding]; other site 639283013038 salt bridge; other site 639283013039 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 639283013040 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 639283013041 classical (c) SDRs; Region: SDR_c; cd05233 639283013042 NAD(P) binding site [chemical binding]; other site 639283013043 active site 639283013044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283013045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 639283013046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 639283013047 Transcriptional regulators [Transcription]; Region: PurR; COG1609 639283013048 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 639283013049 DNA binding site [nucleotide binding] 639283013050 domain linker motif; other site 639283013051 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 639283013052 putative ligand binding site [chemical binding]; other site 639283013053 putative dimerization interface [polypeptide binding]; other site 639283013054 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 639283013055 Dehydratase family; Region: ILVD_EDD; pfam00920 639283013056 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 639283013057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 639283013058 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283013059 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 639283013060 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 639283013061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 639283013062 dimer interface [polypeptide binding]; other site 639283013063 conserved gate region; other site 639283013064 putative PBP binding loops; other site 639283013065 ABC-ATPase subunit interface; other site 639283013066 choline dehydrogenase; Validated; Region: PRK02106 639283013067 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 639283013068 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 639283013069 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 639283013070 tetramerization interface [polypeptide binding]; other site 639283013071 NAD(P) binding site [chemical binding]; other site 639283013072 catalytic residues [active] 639283013073 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 639283013074 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 639283013075 Walker A/P-loop; other site 639283013076 ATP binding site [chemical binding]; other site 639283013077 Q-loop/lid; other site 639283013078 ABC transporter signature motif; other site 639283013079 Walker B; other site 639283013080 D-loop; other site 639283013081 H-loop/switch region; other site 639283013082 TOBE domain; Region: TOBE_2; pfam08402 639283013083 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283013084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 639283013085 DNA-binding site [nucleotide binding]; DNA binding site 639283013086 Transcriptional regulators [Transcription]; Region: GntR; COG1802 639283013087 FCD domain; Region: FCD; pfam07729 639283013088 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 639283013089 tartrate dehydrogenase; Region: TTC; TIGR02089 639283013090 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 639283013091 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 639283013092 NAD(P) binding site [chemical binding]; other site 639283013093 catalytic residues [active] 639283013094 Cupin domain; Region: Cupin_2; pfam07883 639283013095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 639283013096 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 639283013097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 639283013098 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 639283013099 Transposase; Region: HTH_Tnp_1; pfam01527 639283013100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 639283013101 HTH-like domain; Region: HTH_21; pfam13276 639283013102 Integrase core domain; Region: rve; pfam00665 639283013103 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 639283013104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283013105 The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467 639283013106 putative substrate binding pocket [chemical binding]; other site 639283013107 putative dimerization interface [polypeptide binding]; other site 639283013108 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 639283013109 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 639283013110 potential catalytic triad [active] 639283013111 conserved cys residue [active] 639283013112 Uncharacterized conserved protein [Function unknown]; Region: COG1359 639283013113 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 639283013114 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 639283013115 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 639283013116 N-terminal domain interface [polypeptide binding]; other site 639283013117 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 639283013118 putative catalytic residues [active] 639283013119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283013120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283013121 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 639283013122 putative effector binding pocket; other site 639283013123 dimerization interface [polypeptide binding]; other site 639283013124 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 639283013125 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 639283013126 Presynaptic Site I dimer interface [polypeptide binding]; other site 639283013127 catalytic residues [active] 639283013128 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 639283013129 Synaptic Flat tetramer interface [polypeptide binding]; other site 639283013130 Synaptic Site I dimer interface [polypeptide binding]; other site 639283013131 DNA binding site [nucleotide binding] 639283013132 Recombinase; Region: Recombinase; pfam07508 639283013133 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 639283013134 active site 639283013135 catalytic residues [active] 639283013136 DNA binding site [nucleotide binding] 639283013137 Int/Topo IB signature motif; other site 639283013138 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 639283013139 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 639283013140 tape measure domain; Region: tape_meas_nterm; TIGR02675 639283013141 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 639283013142 AAA domain; Region: AAA_25; pfam13481 639283013143 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 639283013144 Walker A motif; other site 639283013145 ATP binding site [chemical binding]; other site 639283013146 Walker B motif; other site 639283013147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 639283013148 putative DNA binding site [nucleotide binding]; other site 639283013149 putative Zn2+ binding site [ion binding]; other site 639283013150 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 639283013151 active site 639283013152 Int/Topo IB signature motif; other site 639283013153 catalytic residues [active] 639283013154 DNA binding site [nucleotide binding] 639283013155 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 639283013156 HlyD family secretion protein; Region: HlyD_3; pfam13437 639283013157 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 639283013158 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 639283013159 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 639283013160 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 639283013161 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 639283013162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 639283013163 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 639283013164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 639283013165 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 639283013166 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 639283013167 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 639283013168 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 639283013169 muropeptide transporter; Validated; Region: ampG; cl17669 639283013170 muropeptide transporter; Reviewed; Region: ampG; PRK11902 639283013171 recombination protein RecR; Reviewed; Region: recR; PRK00076 639283013172 RecR protein; Region: RecR; pfam02132 639283013173 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 639283013174 putative active site [active] 639283013175 putative metal-binding site [ion binding]; other site 639283013176 tetramer interface [polypeptide binding]; other site 639283013177 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 639283013178 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 639283013179 transmembrane helices; other site 639283013180 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 639283013181 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 639283013182 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 639283013183 active site 639283013184 substrate-binding site [chemical binding]; other site 639283013185 metal-binding site [ion binding] 639283013186 ATP binding site [chemical binding]; other site 639283013187 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 639283013188 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 639283013189 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 639283013190 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 639283013191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 639283013192 active site 639283013193 phosphorylation site [posttranslational modification] 639283013194 intermolecular recognition site; other site 639283013195 dimerization interface [polypeptide binding]; other site 639283013196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 639283013197 DNA binding site [nucleotide binding] 639283013198 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 639283013199 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 639283013200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 639283013201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 639283013202 dimer interface [polypeptide binding]; other site 639283013203 phosphorylation site [posttranslational modification] 639283013204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 639283013205 ATP binding site [chemical binding]; other site 639283013206 Mg2+ binding site [ion binding]; other site 639283013207 G-X-G motif; other site 639283013208 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 639283013209 Hpr binding site; other site 639283013210 active site 639283013211 homohexamer subunit interaction site [polypeptide binding]; other site 639283013212 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 639283013213 active pocket/dimerization site; other site 639283013214 active site 639283013215 phosphorylation site [posttranslational modification] 639283013216 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 639283013217 regulatory protein interface [polypeptide binding]; other site 639283013218 active site 639283013219 regulatory phosphorylation site [posttranslational modification]; other site 639283013220 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 639283013221 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 639283013222 homotetramer interface [polypeptide binding]; other site 639283013223 ligand binding site [chemical binding]; other site 639283013224 catalytic site [active] 639283013225 NAD binding site [chemical binding]; other site 639283013226 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 639283013227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 639283013228 Coenzyme A binding pocket [chemical binding]; other site 639283013229 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 639283013230 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 639283013231 FAD binding pocket [chemical binding]; other site 639283013232 FAD binding motif [chemical binding]; other site 639283013233 phosphate binding motif [ion binding]; other site 639283013234 beta-alpha-beta structure motif; other site 639283013235 NAD binding pocket [chemical binding]; other site 639283013236 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 639283013237 PAS domain; Region: PAS_9; pfam13426 639283013238 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 639283013239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 639283013240 metal binding site [ion binding]; metal-binding site 639283013241 active site 639283013242 I-site; other site 639283013243 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 639283013244 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 639283013245 NAD(P) binding site [chemical binding]; other site 639283013246 catalytic residues [active] 639283013247 putative chaperone; Provisional; Region: PRK11678 639283013248 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 639283013249 nucleotide binding site [chemical binding]; other site 639283013250 putative NEF/HSP70 interaction site [polypeptide binding]; other site 639283013251 SBD interface [polypeptide binding]; other site 639283013252 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 639283013253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 639283013254 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 639283013255 putative active site [active] 639283013256 YdjC motif; other site 639283013257 Mg binding site [ion binding]; other site 639283013258 putative homodimer interface [polypeptide binding]; other site 639283013259 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 639283013260 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 639283013261 Ligand binding site; other site 639283013262 Putative Catalytic site; other site 639283013263 DXD motif; other site 639283013264 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 639283013265 Predicted membrane protein [Function unknown]; Region: COG2246 639283013266 GtrA-like protein; Region: GtrA; pfam04138 639283013267 Uncharacterized conserved protein [Function unknown]; Region: COG4544 639283013268 DNA Polymerase Y-family; Region: PolY_like; cd03468 639283013269 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 639283013270 DNA binding site [nucleotide binding] 639283013271 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 639283013272 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 639283013273 putative active site [active] 639283013274 putative PHP Thumb interface [polypeptide binding]; other site 639283013275 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 639283013276 generic binding surface II; other site 639283013277 generic binding surface I; other site 639283013278 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 639283013279 Predicted membrane protein [Function unknown]; Region: COG2261 639283013280 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 639283013281 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 639283013282 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 639283013283 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 639283013284 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 639283013285 DNA binding residues [nucleotide binding] 639283013286 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 639283013287 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 639283013288 MarR family; Region: MarR; pfam01047 639283013289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 639283013290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 639283013291 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 639283013292 putative effector binding pocket; other site 639283013293 dimerization interface [polypeptide binding]; other site 639283013294 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 639283013295 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283013296 Zn binding site [ion binding]; other site 639283013297 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 639283013298 Zn binding site [ion binding]; other site 639283013299 Predicted esterase [General function prediction only]; Region: COG0400 639283013300 putative hydrolase; Provisional; Region: PRK11460 639283013301 Predicted metalloprotease [General function prediction only]; Region: COG2321 639283013302 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 639283013303 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 639283013304 MPT binding site; other site 639283013305 trimer interface [polypeptide binding]; other site 639283013306 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 639283013307 active site 639283013308 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 639283013309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 639283013310 FeS/SAM binding site; other site 639283013311 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 639283013312 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 639283013313 Thioredoxin; Region: Thioredoxin_4; pfam13462 639283013314 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 639283013315 Protein of unknown function (DUF721); Region: DUF721; cl02324 639283013316 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 639283013317 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 639283013318 minor groove reading motif; other site 639283013319 helix-hairpin-helix signature motif; other site 639283013320 substrate binding pocket [chemical binding]; other site 639283013321 active site 639283013322 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 639283013323 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 639283013324 DNA binding and oxoG recognition site [nucleotide binding] 639283013325 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 639283013326 DNA methylase; Region: N6_N4_Mtase; pfam01555 639283013327 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 639283013328 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 639283013329 AAA domain; Region: AAA_23; pfam13476 639283013330 Walker A/P-loop; other site 639283013331 ATP binding site [chemical binding]; other site 639283013332 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 639283013333 ABC transporter signature motif; other site 639283013334 Walker B; other site 639283013335 D-loop; other site 639283013336 H-loop/switch region; other site 639283013337 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 639283013338 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 639283013339 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 639283013340 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 639283013341 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 639283013342 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 639283013343 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 639283013344 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 639283013345 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 639283013346 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 639283013347 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 639283013348 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 639283013349 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 639283013350 putative active site [active] 639283013351 Zn binding site [ion binding]; other site 639283013352 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 639283013353 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 639283013354 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 639283013355 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 639283013356 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 639283013357 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 639283013358 TPP-binding site; other site 639283013359 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 639283013360 PYR/PP interface [polypeptide binding]; other site 639283013361 dimer interface [polypeptide binding]; other site 639283013362 TPP binding site [chemical binding]; other site 639283013363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 639283013364 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 639283013365 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 639283013366 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 639283013367 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 639283013368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 639283013369 S-adenosylmethionine binding site [chemical binding]; other site 639283013370 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 639283013371 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 639283013372 metal ion-dependent adhesion site (MIDAS); other site 639283013373 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 639283013374 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 639283013375 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 639283013376 dimerization interface [polypeptide binding]; other site 639283013377 active site 639283013378 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 639283013379 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 639283013380 Tetramer interface [polypeptide binding]; other site 639283013381 active site 639283013382 FMN-binding site [chemical binding]; other site 639283013383 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 639283013384 Domain of unknown function DUF21; Region: DUF21; pfam01595 639283013385 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 639283013386 Transporter associated domain; Region: CorC_HlyC; smart01091 639283013387 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 639283013388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 639283013389 ATP binding site [chemical binding]; other site 639283013390 putative Mg++ binding site [ion binding]; other site 639283013391 nucleotide binding region [chemical binding]; other site 639283013392 helicase superfamily c-terminal domain; Region: HELICc; smart00490 639283013393 Helicase associated domain (HA2); Region: HA2; pfam04408 639283013394 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 639283013395 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 639283013396 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 639283013397 inhibitor-cofactor binding pocket; inhibition site 639283013398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283013399 catalytic residue [active] 639283013400 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 639283013401 hydroxyglutarate oxidase; Provisional; Region: PRK11728 639283013402 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 639283013403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 639283013404 active site 639283013405 motif I; other site 639283013406 motif II; other site 639283013407 histidyl-tRNA synthetase; Provisional; Region: PRK12420 639283013408 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 639283013409 dimer interface [polypeptide binding]; other site 639283013410 motif 1; other site 639283013411 motif 2; other site 639283013412 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 639283013413 active site 639283013414 motif 3; other site 639283013415 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 639283013416 anticodon binding site; other site 639283013417 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 639283013418 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 639283013419 motif 1; other site 639283013420 dimer interface [polypeptide binding]; other site 639283013421 active site 639283013422 motif 2; other site 639283013423 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 639283013424 active site 639283013425 motif 3; other site 639283013426 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 639283013427 ATP phosphoribosyltransferase; Region: HisG; cl15266 639283013428 siroheme synthase; Provisional; Region: cysG; PRK10637 639283013429 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 639283013430 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 639283013431 active site 639283013432 SAM binding site [chemical binding]; other site 639283013433 homodimer interface [polypeptide binding]; other site 639283013434 hypothetical protein; Provisional; Region: PRK05208 639283013435 methionine sulfoxide reductase A; Provisional; Region: PRK00058 639283013436 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 639283013437 Low-spin heme binding site [chemical binding]; other site 639283013438 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 639283013439 Putative water exit pathway; other site 639283013440 Binuclear center (active site) [active] 639283013441 Putative proton exit pathway; other site 639283013442 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 639283013443 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 639283013444 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 639283013445 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 639283013446 Cytochrome c; Region: Cytochrom_C; pfam00034 639283013447 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 639283013448 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 639283013449 4Fe-4S binding domain; Region: Fer4_5; pfam12801 639283013450 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 639283013451 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 639283013452 FixH; Region: FixH; pfam05751 639283013453 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 639283013454 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 639283013455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 639283013456 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 639283013457 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 639283013458 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 639283013459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283013460 putative substrate translocation pore; other site 639283013461 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 639283013462 putative acyl-acceptor binding pocket; other site 639283013463 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 639283013464 acyl-activating enzyme (AAE) consensus motif; other site 639283013465 AMP binding site [chemical binding]; other site 639283013466 active site 639283013467 CoA binding site [chemical binding]; other site 639283013468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 639283013469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 639283013470 hypothetical protein; Validated; Region: PRK00153 639283013471 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 639283013472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 639283013473 Walker A motif; other site 639283013474 ATP binding site [chemical binding]; other site 639283013475 Walker B motif; other site 639283013476 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 639283013477 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 639283013478 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 639283013479 Cupin domain; Region: Cupin_2; cl17218 639283013480 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 639283013481 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 639283013482 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 639283013483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 639283013484 Major Facilitator Superfamily; Region: MFS_1; pfam07690 639283013485 putative substrate translocation pore; other site 639283013486 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 639283013487 HIT family signature motif; other site 639283013488 catalytic residue [active] 639283013489 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 639283013490 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 639283013491 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 639283013492 putative NADH binding site [chemical binding]; other site 639283013493 putative active site [active] 639283013494 nudix motif; other site 639283013495 putative metal binding site [ion binding]; other site 639283013496 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 639283013497 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 639283013498 trimer interface [polypeptide binding]; other site 639283013499 active site 639283013500 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 639283013501 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 639283013502 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 639283013503 homodimer interface [polypeptide binding]; other site 639283013504 substrate-cofactor binding pocket; other site 639283013505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283013506 catalytic residue [active] 639283013507 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 639283013508 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 639283013509 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 639283013510 acetylornithine deacetylase; Provisional; Region: PRK07522 639283013511 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 639283013512 metal binding site [ion binding]; metal-binding site 639283013513 putative dimer interface [polypeptide binding]; other site 639283013514 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 639283013515 dimerization interface [polypeptide binding]; other site 639283013516 domain crossover interface; other site 639283013517 redox-dependent activation switch; other site 639283013518 ornithine carbamoyltransferase; Provisional; Region: PRK00779 639283013519 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 639283013520 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 639283013521 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 639283013522 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 639283013523 inhibitor-cofactor binding pocket; inhibition site 639283013524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 639283013525 catalytic residue [active] 639283013526 GcrA cell cycle regulator; Region: GcrA; cl11564 639283013527 Protein of unknown function DUF45; Region: DUF45; pfam01863 639283013528 Transglycosylase; Region: Transgly; pfam00912 639283013529 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 639283013530 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 639283013531 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 639283013532 DNA binding site [nucleotide binding] 639283013533 Int/Topo IB signature motif; other site 639283013534 active site 639283013535 catalytic residues [active] 639283013536 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 639283013537 DNA polymerase III subunit beta; Provisional; Region: PRK14945 639283013538 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 639283013539 putative DNA binding surface [nucleotide binding]; other site 639283013540 dimer interface [polypeptide binding]; other site 639283013541 beta-clamp/clamp loader binding surface; other site 639283013542 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 639283013543 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 639283013544 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 639283013545 Catalytic site [active]