-- dump date   	20140620_080602
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
868597000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
868597000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
868597000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597000004	ATP binding site [chemical binding]; other site
868597000005	Walker B motif; other site
868597000006	arginine finger; other site
868597000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
868597000008	DnaA box-binding interface [nucleotide binding]; other site
868597000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
868597000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
868597000011	putative DNA binding surface [nucleotide binding]; other site
868597000012	dimer interface [polypeptide binding]; other site
868597000013	beta-clamp/clamp loader binding surface; other site
868597000014	beta-clamp/translesion DNA polymerase binding surface; other site
868597000015	recombination protein F; Reviewed; Region: recF; PRK00064
868597000016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597000017	Walker A/P-loop; other site
868597000018	ATP binding site [chemical binding]; other site
868597000019	Q-loop/lid; other site
868597000020	ABC transporter signature motif; other site
868597000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597000022	ABC transporter signature motif; other site
868597000023	Walker B; other site
868597000024	D-loop; other site
868597000025	H-loop/switch region; other site
868597000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
868597000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597000028	Mg2+ binding site [ion binding]; other site
868597000029	G-X-G motif; other site
868597000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
868597000031	anchoring element; other site
868597000032	dimer interface [polypeptide binding]; other site
868597000033	ATP binding site [chemical binding]; other site
868597000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
868597000035	active site
868597000036	putative metal-binding site [ion binding]; other site
868597000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
868597000038	CAAX protease self-immunity; Region: Abi; pfam02517
868597000039	Peptidase family M48; Region: Peptidase_M48; pfam01435
868597000040	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
868597000041	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
868597000042	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597000043	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
868597000044	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
868597000045	TolR protein; Region: tolR; TIGR02801
868597000046	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
868597000047	TolR protein; Region: tolR; TIGR02801
868597000048	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
868597000049	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
868597000050	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
868597000051	putative active site [active]
868597000052	catalytic site [active]
868597000053	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
868597000054	putative active site [active]
868597000055	catalytic site [active]
868597000056	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
868597000057	active site
868597000058	hydrophilic channel; other site
868597000059	dimerization interface [polypeptide binding]; other site
868597000060	catalytic residues [active]
868597000061	active site lid [active]
868597000062	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
868597000063	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597000064	FeS/SAM binding site; other site
868597000065	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
868597000066	fructose-1,6-bisphosphatase family protein; Region: PLN02628
868597000067	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
868597000068	AMP binding site [chemical binding]; other site
868597000069	metal binding site [ion binding]; metal-binding site
868597000070	active site
868597000071	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
868597000072	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597000073	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597000074	homodimer interface [polypeptide binding]; other site
868597000075	catalytic residue [active]
868597000076	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597000077	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597000078	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
868597000079	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
868597000080	putative DNA binding site [nucleotide binding]; other site
868597000081	putative homodimer interface [polypeptide binding]; other site
868597000082	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
868597000083	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
868597000084	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
868597000085	active site
868597000086	DNA binding site [nucleotide binding]
868597000087	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
868597000088	DNA binding site [nucleotide binding]
868597000089	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
868597000090	nucleotide binding site [chemical binding]; other site
868597000091	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
868597000092	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
868597000093	NAD binding site [chemical binding]; other site
868597000094	substrate binding site [chemical binding]; other site
868597000095	catalytic Zn binding site [ion binding]; other site
868597000096	tetramer interface [polypeptide binding]; other site
868597000097	structural Zn binding site [ion binding]; other site
868597000098	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
868597000099	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
868597000100	active site
868597000101	intersubunit interface [polypeptide binding]; other site
868597000102	catalytic residue [active]
868597000103	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
868597000104	Transcriptional regulators [Transcription]; Region: PurR; COG1609
868597000105	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
868597000106	DNA binding site [nucleotide binding]
868597000107	domain linker motif; other site
868597000108	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
868597000109	putative dimerization interface [polypeptide binding]; other site
868597000110	putative ligand binding site [chemical binding]; other site
868597000111	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
868597000112	cofactor binding site; other site
868597000113	metal binding site [ion binding]; metal-binding site
868597000114	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
868597000115	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597000116	dimerization interface [polypeptide binding]; other site
868597000117	putative DNA binding site [nucleotide binding]; other site
868597000118	putative Zn2+ binding site [ion binding]; other site
868597000119	AsnC family; Region: AsnC_trans_reg; pfam01037
868597000120	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
868597000121	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
868597000122	nucleophile elbow; other site
868597000123	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
868597000124	Uncharacterized conserved protein [Function unknown]; Region: COG2013
868597000125	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597000126	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597000127	N-terminal plug; other site
868597000128	ligand-binding site [chemical binding]; other site
868597000129	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
868597000130	active site
868597000131	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
868597000132	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
868597000133	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597000134	Walker A/P-loop; other site
868597000135	ATP binding site [chemical binding]; other site
868597000136	Q-loop/lid; other site
868597000137	ABC transporter signature motif; other site
868597000138	Walker B; other site
868597000139	D-loop; other site
868597000140	H-loop/switch region; other site
868597000141	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
868597000142	Fatty acid desaturase; Region: FA_desaturase; pfam00487
868597000143	Di-iron ligands [ion binding]; other site
868597000144	EF-hand domain pair; Region: EF_hand_5; pfam13499
868597000145	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
868597000146	Ca2+ binding site [ion binding]; other site
868597000147	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
868597000148	EF-hand domain pair; Region: EF_hand_5; pfam13499
868597000149	Ca2+ binding site [ion binding]; other site
868597000150	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
868597000151	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
868597000152	DNA binding site [nucleotide binding]
868597000153	catalytic residue [active]
868597000154	H2TH interface [polypeptide binding]; other site
868597000155	putative catalytic residues [active]
868597000156	turnover-facilitating residue; other site
868597000157	intercalation triad [nucleotide binding]; other site
868597000158	8OG recognition residue [nucleotide binding]; other site
868597000159	putative reading head residues; other site
868597000160	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
868597000161	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
868597000162	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
868597000163	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
868597000164	thymidine kinase; Provisional; Region: PRK04296
868597000165	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
868597000166	Sel1 repeat; Region: Sel1; cl02723
868597000167	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
868597000168	Part of AAA domain; Region: AAA_19; pfam13245
868597000169	Family description; Region: UvrD_C_2; pfam13538
868597000170	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
868597000171	hypothetical protein; Provisional; Region: PRK11239
868597000172	Protein of unknown function, DUF480; Region: DUF480; pfam04337
868597000173	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597000174	active site
868597000175	motif I; other site
868597000176	motif II; other site
868597000177	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
868597000178	active site
868597000179	dimer interface [polypeptide binding]; other site
868597000180	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
868597000181	active site
868597000182	substrate binding sites [chemical binding]; other site
868597000183	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
868597000184	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
868597000185	putative acyl-acceptor binding pocket; other site
868597000186	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
868597000187	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
868597000188	Ligand Binding Site [chemical binding]; other site
868597000189	recombination associated protein; Reviewed; Region: rdgC; PRK00321
868597000190	Protein of unknown function DUF45; Region: DUF45; pfam01863
868597000191	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
868597000192	substrate binding site [chemical binding]; other site
868597000193	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
868597000194	substrate binding site [chemical binding]; other site
868597000195	PAS fold; Region: PAS_3; pfam08447
868597000196	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597000197	dimer interface [polypeptide binding]; other site
868597000198	phosphorylation site [posttranslational modification]
868597000199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597000200	ATP binding site [chemical binding]; other site
868597000201	Mg2+ binding site [ion binding]; other site
868597000202	G-X-G motif; other site
868597000203	Response regulator receiver domain; Region: Response_reg; pfam00072
868597000204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597000205	active site
868597000206	phosphorylation site [posttranslational modification]
868597000207	intermolecular recognition site; other site
868597000208	dimerization interface [polypeptide binding]; other site
868597000209	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
868597000210	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
868597000211	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
868597000212	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
868597000213	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
868597000214	active site
868597000215	dimer interface [polypeptide binding]; other site
868597000216	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
868597000217	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
868597000218	active site
868597000219	FMN binding site [chemical binding]; other site
868597000220	substrate binding site [chemical binding]; other site
868597000221	3Fe-4S cluster binding site [ion binding]; other site
868597000222	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
868597000223	domain interface; other site
868597000224	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
868597000225	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
868597000226	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
868597000227	active site
868597000228	DNA binding site [nucleotide binding]
868597000229	Int/Topo IB signature motif; other site
868597000230	catalytic residues [active]
868597000231	short chain dehydrogenase; Provisional; Region: PRK06701
868597000232	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597000233	NAD(P) binding site [chemical binding]; other site
868597000234	active site
868597000235	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
868597000236	Beta-lactamase; Region: Beta-lactamase; pfam00144
868597000237	Penicillinase repressor; Region: Pencillinase_R; pfam03965
868597000238	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
868597000239	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
868597000240	RNase_H superfamily; Region: RNase_H_2; pfam13482
868597000241	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
868597000242	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
868597000243	ATP binding site [chemical binding]; other site
868597000244	putative Mg++ binding site [ion binding]; other site
868597000245	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597000246	nucleotide binding region [chemical binding]; other site
868597000247	ATP-binding site [chemical binding]; other site
868597000248	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
868597000249	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
868597000250	Protein of unknown function DUF58; Region: DUF58; pfam01882
868597000251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597000252	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
868597000253	Walker A motif; other site
868597000254	ATP binding site [chemical binding]; other site
868597000255	Walker B motif; other site
868597000256	arginine finger; other site
868597000257	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
868597000258	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
868597000259	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
868597000260	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
868597000261	Protein of unknown function (DUF938); Region: DUF938; pfam06080
868597000262	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
868597000263	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
868597000264	dimer interface [polypeptide binding]; other site
868597000265	PYR/PP interface [polypeptide binding]; other site
868597000266	TPP binding site [chemical binding]; other site
868597000267	substrate binding site [chemical binding]; other site
868597000268	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
868597000269	TPP-binding site; other site
868597000270	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
868597000271	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
868597000272	binding surface
868597000273	TPR motif; other site
868597000274	Ycf46; Provisional; Region: ycf46; CHL00195
868597000275	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597000276	Walker A motif; other site
868597000277	ATP binding site [chemical binding]; other site
868597000278	Walker B motif; other site
868597000279	arginine finger; other site
868597000280	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
868597000281	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
868597000282	P-loop; other site
868597000283	Magnesium ion binding site [ion binding]; other site
868597000284	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
868597000285	catalytic core [active]
868597000286	YceI-like domain; Region: YceI; pfam04264
868597000287	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
868597000288	PLD-like domain; Region: PLDc_2; pfam13091
868597000289	putative active site [active]
868597000290	catalytic site [active]
868597000291	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
868597000292	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
868597000293	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
868597000294	putative active site [active]
868597000295	catalytic site [active]
868597000296	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
868597000297	CoenzymeA binding site [chemical binding]; other site
868597000298	subunit interaction site [polypeptide binding]; other site
868597000299	PHB binding site; other site
868597000300	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
868597000301	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
868597000302	putative acyl-acceptor binding pocket; other site
868597000303	putative hydrolase; Provisional; Region: PRK10985
868597000304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597000305	binding surface
868597000306	TPR motif; other site
868597000307	TPR repeat; Region: TPR_11; pfam13414
868597000308	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
868597000309	substrate binding site [chemical binding]; other site
868597000310	META domain; Region: META; cl01245
868597000311	META domain; Region: META; pfam03724
868597000312	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
868597000313	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
868597000314	glutamine synthetase; Provisional; Region: glnA; PRK09469
868597000315	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
868597000316	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
868597000317	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
868597000318	Nitrogen regulatory protein P-II; Region: P-II; smart00938
868597000319	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
868597000320	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
868597000321	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
868597000322	amidase catalytic site [active]
868597000323	Zn binding residues [ion binding]; other site
868597000324	substrate binding site [chemical binding]; other site
868597000325	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
868597000326	MltA specific insert domain; Region: MltA; smart00925
868597000327	3D domain; Region: 3D; pfam06725
868597000328	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
868597000329	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597000330	non-specific DNA binding site [nucleotide binding]; other site
868597000331	salt bridge; other site
868597000332	sequence-specific DNA binding site [nucleotide binding]; other site
868597000333	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
868597000334	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
868597000335	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
868597000336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597000337	ATP binding site [chemical binding]; other site
868597000338	Mg2+ binding site [ion binding]; other site
868597000339	G-X-G motif; other site
868597000340	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
868597000341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597000342	active site
868597000343	phosphorylation site [posttranslational modification]
868597000344	intermolecular recognition site; other site
868597000345	dimerization interface [polypeptide binding]; other site
868597000346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597000347	Walker A motif; other site
868597000348	ATP binding site [chemical binding]; other site
868597000349	Walker B motif; other site
868597000350	arginine finger; other site
868597000351	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
868597000352	active site
868597000353	Cu2+ binding site [ion binding]; other site
868597000354	E-class dimer interface [polypeptide binding]; other site
868597000355	Zn2+ binding site [ion binding]; other site
868597000356	P-class dimer interface [polypeptide binding]; other site
868597000357	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
868597000358	E-class dimer interface [polypeptide binding]; other site
868597000359	P-class dimer interface [polypeptide binding]; other site
868597000360	active site
868597000361	Cu2+ binding site [ion binding]; other site
868597000362	Zn2+ binding site [ion binding]; other site
868597000363	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
868597000364	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
868597000365	dimer interface [polypeptide binding]; other site
868597000366	active site
868597000367	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
868597000368	HemY protein N-terminus; Region: HemY_N; pfam07219
868597000369	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
868597000370	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
868597000371	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
868597000372	active site
868597000373	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
868597000374	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
868597000375	active site residue [active]
868597000376	preprotein translocase subunit SecB; Validated; Region: PRK05751
868597000377	SecA binding site; other site
868597000378	Preprotein binding site; other site
868597000379	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
868597000380	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
868597000381	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
868597000382	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
868597000383	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
868597000384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597000385	Coenzyme A binding pocket [chemical binding]; other site
868597000386	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
868597000387	Phage Tail Collar Domain; Region: Collar; pfam07484
868597000388	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
868597000389	Phage Tail Collar Domain; Region: Collar; pfam07484
868597000390	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
868597000391	Phage Tail Collar Domain; Region: Collar; pfam07484
868597000392	Putative Ig domain; Region: He_PIG; pfam05345
868597000393	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
868597000394	Autotransporter beta-domain; Region: Autotransporter; pfam03797
868597000395	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428
868597000396	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316
868597000397	sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273
868597000398	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597000399	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
868597000400	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
868597000401	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
868597000402	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
868597000403	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597000404	N-terminal plug; other site
868597000405	ligand-binding site [chemical binding]; other site
868597000406	Phosphotransferase enzyme family; Region: APH; pfam01636
868597000407	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
868597000408	active site
868597000409	ATP binding site [chemical binding]; other site
868597000410	substrate binding site [chemical binding]; other site
868597000411	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
868597000412	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597000413	catalytic residue [active]
868597000414	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
868597000415	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597000416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597000417	active site
868597000418	phosphorylation site [posttranslational modification]
868597000419	intermolecular recognition site; other site
868597000420	dimerization interface [polypeptide binding]; other site
868597000421	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597000422	DNA binding residues [nucleotide binding]
868597000423	dimerization interface [polypeptide binding]; other site
868597000424	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
868597000425	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
868597000426	substrate binding pocket [chemical binding]; other site
868597000427	membrane-bound complex binding site; other site
868597000428	hinge residues; other site
868597000429	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
868597000430	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
868597000431	substrate binding pocket [chemical binding]; other site
868597000432	membrane-bound complex binding site; other site
868597000433	hinge residues; other site
868597000434	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597000435	dimer interface [polypeptide binding]; other site
868597000436	phosphorylation site [posttranslational modification]
868597000437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597000438	ATP binding site [chemical binding]; other site
868597000439	Mg2+ binding site [ion binding]; other site
868597000440	G-X-G motif; other site
868597000441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597000442	active site
868597000443	phosphorylation site [posttranslational modification]
868597000444	intermolecular recognition site; other site
868597000445	dimerization interface [polypeptide binding]; other site
868597000446	Cytochrome c; Region: Cytochrom_C; cl11414
868597000447	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
868597000448	hydroxyglutarate oxidase; Provisional; Region: PRK11728
868597000449	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
868597000450	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
868597000451	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
868597000452	active site
868597000453	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
868597000454	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
868597000455	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
868597000456	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
868597000457	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
868597000458	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
868597000459	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
868597000460	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
868597000461	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
868597000462	dimer interface [polypeptide binding]; other site
868597000463	active site
868597000464	CoA binding pocket [chemical binding]; other site
868597000465	haloalkane dehalogenase; Provisional; Region: PRK00870
868597000466	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
868597000467	peptide synthase; Provisional; Region: PRK09274
868597000468	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
868597000469	acyl-activating enzyme (AAE) consensus motif; other site
868597000470	putative AMP binding site [chemical binding]; other site
868597000471	putative active site [active]
868597000472	putative CoA binding site [chemical binding]; other site
868597000473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597000474	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
868597000475	NAD(P) binding site [chemical binding]; other site
868597000476	active site
868597000477	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
868597000478	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
868597000479	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
868597000480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
868597000481	SCP-2 sterol transfer family; Region: SCP2; pfam02036
868597000482	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
868597000483	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
868597000484	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
868597000485	putative trimer interface [polypeptide binding]; other site
868597000486	putative CoA binding site [chemical binding]; other site
868597000487	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
868597000488	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
868597000489	DXD motif; other site
868597000490	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
868597000491	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
868597000492	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597000493	S-adenosylmethionine binding site [chemical binding]; other site
868597000494	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
868597000495	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
868597000496	active site
868597000497	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
868597000498	hypothetical protein; Provisional; Region: PRK09256
868597000499	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
868597000500	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
868597000501	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
868597000502	putative acyl-acceptor binding pocket; other site
868597000503	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
868597000504	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
868597000505	active site
868597000506	Zn binding site [ion binding]; other site
868597000507	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
868597000508	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
868597000509	Catalytic site [active]
868597000510	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
868597000511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597000512	putative substrate translocation pore; other site
868597000513	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
868597000514	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
868597000515	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597000516	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
868597000517	dimerization interface [polypeptide binding]; other site
868597000518	substrate binding pocket [chemical binding]; other site
868597000519	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597000520	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597000521	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
868597000522	dimerization interface [polypeptide binding]; other site
868597000523	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
868597000524	malate synthase A; Region: malate_syn_A; TIGR01344
868597000525	active site
868597000526	isocitrate lyase; Provisional; Region: PRK15063
868597000527	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
868597000528	tetramer interface [polypeptide binding]; other site
868597000529	active site
868597000530	Mg2+/Mn2+ binding site [ion binding]; other site
868597000531	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
868597000532	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
868597000533	ligand binding site [chemical binding]; other site
868597000534	flexible hinge region; other site
868597000535	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597000536	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597000537	metal binding site [ion binding]; metal-binding site
868597000538	active site
868597000539	I-site; other site
868597000540	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
868597000541	cyclase homology domain; Region: CHD; cd07302
868597000542	nucleotidyl binding site; other site
868597000543	metal binding site [ion binding]; metal-binding site
868597000544	dimer interface [polypeptide binding]; other site
868597000545	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597000546	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
868597000547	putative FMN binding site [chemical binding]; other site
868597000548	NADPH bind site [chemical binding]; other site
868597000549	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
868597000550	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
868597000551	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
868597000552	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
868597000553	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
868597000554	carboxyltransferase (CT) interaction site; other site
868597000555	biotinylation site [posttranslational modification]; other site
868597000556	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
868597000557	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
868597000558	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
868597000559	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
868597000560	active site
868597000561	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597000562	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597000563	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
868597000564	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
868597000565	putative active site [active]
868597000566	putative catalytic site [active]
868597000567	putative Mg binding site IVb [ion binding]; other site
868597000568	putative phosphate binding site [ion binding]; other site
868597000569	putative DNA binding site [nucleotide binding]; other site
868597000570	putative Mg binding site IVa [ion binding]; other site
868597000571	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
868597000572	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597000573	Predicted ATPase [General function prediction only]; Region: COG1485
868597000574	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
868597000575	ribonucleoside--diphosphate reductase large subunit; Region: PLN02437
868597000576	ATP cone domain; Region: ATP-cone; pfam03477
868597000577	Class I ribonucleotide reductase; Region: RNR_I; cd01679
868597000578	active site
868597000579	dimer interface [polypeptide binding]; other site
868597000580	catalytic residues [active]
868597000581	effector binding site; other site
868597000582	R2 peptide binding site; other site
868597000583	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
868597000584	dimer interface [polypeptide binding]; other site
868597000585	putative radical transfer pathway; other site
868597000586	diiron center [ion binding]; other site
868597000587	tyrosyl radical; other site
868597000588	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
868597000589	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
868597000590	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
868597000591	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
868597000592	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
868597000593	cofactor binding site; other site
868597000594	DNA binding site [nucleotide binding]
868597000595	substrate interaction site [chemical binding]; other site
868597000596	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
868597000597	NAD-dependent deacetylase; Provisional; Region: PRK05333
868597000598	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
868597000599	NAD+ binding site [chemical binding]; other site
868597000600	substrate binding site [chemical binding]; other site
868597000601	Zn binding site [ion binding]; other site
868597000602	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
868597000603	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
868597000604	active site
868597000605	FMN binding site [chemical binding]; other site
868597000606	substrate binding site [chemical binding]; other site
868597000607	homotetramer interface [polypeptide binding]; other site
868597000608	catalytic residue [active]
868597000609	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597000610	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597000611	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597000612	putative effector binding pocket; other site
868597000613	dimerization interface [polypeptide binding]; other site
868597000614	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
868597000615	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
868597000616	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
868597000617	putative active site [active]
868597000618	putative substrate binding site [chemical binding]; other site
868597000619	putative cosubstrate binding site; other site
868597000620	catalytic site [active]
868597000621	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
868597000622	catalytic triad [active]
868597000623	metal binding site [ion binding]; metal-binding site
868597000624	conserved cis-peptide bond; other site
868597000625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
868597000626	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
868597000627	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
868597000628	active site
868597000629	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
868597000630	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
868597000631	active site
868597000632	nucleotide binding site [chemical binding]; other site
868597000633	HIGH motif; other site
868597000634	KMSKS motif; other site
868597000635	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
868597000636	nudix motif; other site
868597000637	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
868597000638	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
868597000639	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597000640	sequence-specific DNA binding site [nucleotide binding]; other site
868597000641	salt bridge; other site
868597000642	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
868597000643	Domain of unknown function (DUF955); Region: DUF955; pfam06114
868597000644	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
868597000645	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
868597000646	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
868597000647	tetrameric interface [polypeptide binding]; other site
868597000648	NAD binding site [chemical binding]; other site
868597000649	catalytic residues [active]
868597000650	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
868597000651	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
868597000652	active site
868597000653	enoyl-CoA hydratase; Provisional; Region: PRK09076
868597000654	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
868597000655	substrate binding site [chemical binding]; other site
868597000656	oxyanion hole (OAH) forming residues; other site
868597000657	trimer interface [polypeptide binding]; other site
868597000658	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
868597000659	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
868597000660	substrate binding site [chemical binding]; other site
868597000661	oxyanion hole (OAH) forming residues; other site
868597000662	trimer interface [polypeptide binding]; other site
868597000663	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
868597000664	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
868597000665	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
868597000666	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
868597000667	active site
868597000668	Zn binding site [ion binding]; other site
868597000669	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
868597000670	Cation efflux family; Region: Cation_efflux; cl00316
868597000671	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
868597000672	oligomerization interface [polypeptide binding]; other site
868597000673	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
868597000674	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
868597000675	Phage tail protein; Region: Phage_tail_3; pfam08813
868597000676	Domain of unknown function (DUF1789); Region: DUF1789; pfam08748
868597000677	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
868597000678	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
868597000679	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
868597000680	Phage-related minor tail protein [Function unknown]; Region: COG5281
868597000681	Phage minor tail protein; Region: Phage_min_tail; cl01940
868597000682	Phage minor tail protein L; Region: Phage_tail_L; cl01908
868597000683	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
868597000684	MPN+ (JAMM) motif; other site
868597000685	Zinc-binding site [ion binding]; other site
868597000686	NlpC/P60 family; Region: NLPC_P60; cl17555
868597000687	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
868597000688	Phage-related protein, tail component [Function unknown]; Region: COG4723
868597000689	Phage-related protein, tail component [Function unknown]; Region: COG4733
868597000690	Putative phage tail protein; Region: Phage-tail_3; pfam13550
868597000691	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
868597000692	Interdomain contacts; other site
868597000693	Cytokine receptor motif; other site
868597000694	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
868597000695	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
868597000696	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
868597000697	Sulfate transporter family; Region: Sulfate_transp; pfam00916
868597000698	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
868597000699	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
868597000700	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
868597000701	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
868597000702	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
868597000703	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
868597000704	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
868597000705	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
868597000706	FMN binding site [chemical binding]; other site
868597000707	active site
868597000708	catalytic residues [active]
868597000709	substrate binding site [chemical binding]; other site
868597000710	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597000711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597000712	active site
868597000713	phosphorylation site [posttranslational modification]
868597000714	intermolecular recognition site; other site
868597000715	dimerization interface [polypeptide binding]; other site
868597000716	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597000717	DNA binding site [nucleotide binding]
868597000718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
868597000719	dimer interface [polypeptide binding]; other site
868597000720	phosphorylation site [posttranslational modification]
868597000721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597000722	ATP binding site [chemical binding]; other site
868597000723	Mg2+ binding site [ion binding]; other site
868597000724	G-X-G motif; other site
868597000725	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
868597000726	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
868597000727	Biotin operon repressor [Transcription]; Region: BirA; COG1654
868597000728	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
868597000729	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
868597000730	pantothenate kinase; Reviewed; Region: PRK13327
868597000731	Sporulation related domain; Region: SPOR; cl10051
868597000732	Sporulation related domain; Region: SPOR; pfam05036
868597000733	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
868597000734	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
868597000735	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
868597000736	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
868597000737	active site
868597000738	oxyanion hole [active]
868597000739	catalytic triad [active]
868597000740	Arginase family; Region: Arginase; cd09989
868597000741	agmatinase; Region: agmatinase; TIGR01230
868597000742	active site
868597000743	Mn binding site [ion binding]; other site
868597000744	oligomer interface [polypeptide binding]; other site
868597000745	Predicted small secreted protein [Function unknown]; Region: COG5510
868597000746	CsbD-like; Region: CsbD; cl17424
868597000747	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
868597000748	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
868597000749	active site
868597000750	HIGH motif; other site
868597000751	dimer interface [polypeptide binding]; other site
868597000752	KMSKS motif; other site
868597000753	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
868597000754	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
868597000755	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
868597000756	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
868597000757	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
868597000758	PA/protease or protease-like domain interface [polypeptide binding]; other site
868597000759	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
868597000760	metal binding site [ion binding]; metal-binding site
868597000761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597000762	metabolite-proton symporter; Region: 2A0106; TIGR00883
868597000763	putative substrate translocation pore; other site
868597000764	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
868597000765	EamA-like transporter family; Region: EamA; pfam00892
868597000766	EamA-like transporter family; Region: EamA; pfam00892
868597000767	Predicted permeases [General function prediction only]; Region: RarD; COG2962
868597000768	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597000769	N-terminal plug; other site
868597000770	ligand-binding site [chemical binding]; other site
868597000771	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597000772	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
868597000773	FtsX-like permease family; Region: FtsX; pfam02687
868597000774	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597000775	FtsX-like permease family; Region: FtsX; pfam02687
868597000776	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
868597000777	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
868597000778	Walker A/P-loop; other site
868597000779	ATP binding site [chemical binding]; other site
868597000780	Q-loop/lid; other site
868597000781	ABC transporter signature motif; other site
868597000782	Walker B; other site
868597000783	D-loop; other site
868597000784	H-loop/switch region; other site
868597000785	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597000786	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597000787	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597000788	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
868597000789	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
868597000790	Walker A/P-loop; other site
868597000791	ATP binding site [chemical binding]; other site
868597000792	Q-loop/lid; other site
868597000793	ABC transporter signature motif; other site
868597000794	Walker B; other site
868597000795	D-loop; other site
868597000796	H-loop/switch region; other site
868597000797	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
868597000798	Histidine kinase; Region: HisKA_3; pfam07730
868597000799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597000800	ATP binding site [chemical binding]; other site
868597000801	Mg2+ binding site [ion binding]; other site
868597000802	G-X-G motif; other site
868597000803	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597000804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597000805	active site
868597000806	phosphorylation site [posttranslational modification]
868597000807	intermolecular recognition site; other site
868597000808	dimerization interface [polypeptide binding]; other site
868597000809	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597000810	DNA binding residues [nucleotide binding]
868597000811	dimerization interface [polypeptide binding]; other site
868597000812	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
868597000813	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
868597000814	putative heme binding pocket [chemical binding]; other site
868597000815	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
868597000816	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
868597000817	interface (dimer of trimers) [polypeptide binding]; other site
868597000818	Substrate-binding/catalytic site; other site
868597000819	Zn-binding sites [ion binding]; other site
868597000820	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
868597000821	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597000822	motif II; other site
868597000823	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
868597000824	Domain of unknown function DUF20; Region: UPF0118; pfam01594
868597000825	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
868597000826	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
868597000827	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
868597000828	protein binding site [polypeptide binding]; other site
868597000829	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
868597000830	protein binding site [polypeptide binding]; other site
868597000831	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
868597000832	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
868597000833	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597000834	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
868597000835	sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273
868597000836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597000837	Response regulator receiver domain; Region: Response_reg; pfam00072
868597000838	active site
868597000839	phosphorylation site [posttranslational modification]
868597000840	intermolecular recognition site; other site
868597000841	dimerization interface [polypeptide binding]; other site
868597000842	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597000843	DNA binding residues [nucleotide binding]
868597000844	dimerization interface [polypeptide binding]; other site
868597000845	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
868597000846	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
868597000847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597000848	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597000849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597000850	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
868597000851	putative dimerization interface [polypeptide binding]; other site
868597000852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
868597000853	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
868597000854	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
868597000855	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
868597000856	malonic semialdehyde reductase; Provisional; Region: PRK10538
868597000857	putative NAD(P) binding site [chemical binding]; other site
868597000858	homotetramer interface [polypeptide binding]; other site
868597000859	homodimer interface [polypeptide binding]; other site
868597000860	active site
868597000861	Sporulation related domain; Region: SPOR; pfam05036
868597000862	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
868597000863	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
868597000864	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
868597000865	active site
868597000866	HIGH motif; other site
868597000867	KMSK motif region; other site
868597000868	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
868597000869	tRNA binding surface [nucleotide binding]; other site
868597000870	anticodon binding site; other site
868597000871	hypothetical protein; Reviewed; Region: PRK00024
868597000872	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
868597000873	MPN+ (JAMM) motif; other site
868597000874	Zinc-binding site [ion binding]; other site
868597000875	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597000876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597000877	active site
868597000878	phosphorylation site [posttranslational modification]
868597000879	intermolecular recognition site; other site
868597000880	dimerization interface [polypeptide binding]; other site
868597000881	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597000882	DNA binding residues [nucleotide binding]
868597000883	dimerization interface [polypeptide binding]; other site
868597000884	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
868597000885	Flavoprotein; Region: Flavoprotein; pfam02441
868597000886	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
868597000887	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
868597000888	trimer interface [polypeptide binding]; other site
868597000889	active site
868597000890	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
868597000891	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
868597000892	active site
868597000893	substrate binding site [chemical binding]; other site
868597000894	metal binding site [ion binding]; metal-binding site
868597000895	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597000896	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597000897	active site
868597000898	phosphorylation site [posttranslational modification]
868597000899	intermolecular recognition site; other site
868597000900	dimerization interface [polypeptide binding]; other site
868597000901	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597000902	DNA binding site [nucleotide binding]
868597000903	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
868597000904	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
868597000905	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
868597000906	Ligand Binding Site [chemical binding]; other site
868597000907	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597000908	dimer interface [polypeptide binding]; other site
868597000909	phosphorylation site [posttranslational modification]
868597000910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597000911	ATP binding site [chemical binding]; other site
868597000912	Mg2+ binding site [ion binding]; other site
868597000913	G-X-G motif; other site
868597000914	K+-transporting ATPase, c chain; Region: KdpC; cl00944
868597000915	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
868597000916	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
868597000917	Soluble P-type ATPase [General function prediction only]; Region: COG4087
868597000918	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
868597000919	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
868597000920	active site
868597000921	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
868597000922	putative active site [active]
868597000923	putative catalytic site [active]
868597000924	putative DNA binding site [nucleotide binding]; other site
868597000925	putative phosphate binding site [ion binding]; other site
868597000926	metal binding site A [ion binding]; metal-binding site
868597000927	putative AP binding site [nucleotide binding]; other site
868597000928	putative metal binding site B [ion binding]; other site
868597000929	muropeptide transporter; Reviewed; Region: ampG; PRK11902
868597000930	muropeptide transporter; Validated; Region: ampG; cl17669
868597000931	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
868597000932	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
868597000933	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
868597000934	Peptidase family M23; Region: Peptidase_M23; pfam01551
868597000935	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
868597000936	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
868597000937	active site
868597000938	HIGH motif; other site
868597000939	dimer interface [polypeptide binding]; other site
868597000940	KMSKS motif; other site
868597000941	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597000942	RNA binding surface [nucleotide binding]; other site
868597000943	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
868597000944	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
868597000945	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
868597000946	PA/protease or protease-like domain interface [polypeptide binding]; other site
868597000947	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
868597000948	metal binding site [ion binding]; metal-binding site
868597000949	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
868597000950	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
868597000951	Peptidase family M23; Region: Peptidase_M23; pfam01551
868597000952	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
868597000953	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
868597000954	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
868597000955	protein binding site [polypeptide binding]; other site
868597000956	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
868597000957	Catalytic dyad [active]
868597000958	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
868597000959	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
868597000960	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
868597000961	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
868597000962	active site
868597000963	nucleotide binding site [chemical binding]; other site
868597000964	HIGH motif; other site
868597000965	KMSKS motif; other site
868597000966	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
868597000967	AAA domain; Region: AAA_28; pfam13521
868597000968	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
868597000969	Proline dehydrogenase; Region: Pro_dh; pfam01619
868597000970	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
868597000971	Glutamate binding site [chemical binding]; other site
868597000972	NAD binding site [chemical binding]; other site
868597000973	catalytic residues [active]
868597000974	Integral membrane protein (DUF2244); Region: DUF2244; cl02302
868597000975	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
868597000976	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
868597000977	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
868597000978	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
868597000979	Subunit I/III interface [polypeptide binding]; other site
868597000980	D-pathway; other site
868597000981	Subunit I/VIIc interface [polypeptide binding]; other site
868597000982	Subunit I/IV interface [polypeptide binding]; other site
868597000983	Subunit I/II interface [polypeptide binding]; other site
868597000984	Low-spin heme (heme a) binding site [chemical binding]; other site
868597000985	Subunit I/VIIa interface [polypeptide binding]; other site
868597000986	Subunit I/VIa interface [polypeptide binding]; other site
868597000987	Dimer interface; other site
868597000988	Putative water exit pathway; other site
868597000989	Binuclear center (heme a3/CuB) [ion binding]; other site
868597000990	K-pathway; other site
868597000991	Subunit I/Vb interface [polypeptide binding]; other site
868597000992	Putative proton exit pathway; other site
868597000993	Subunit I/VIb interface; other site
868597000994	Subunit I/VIc interface [polypeptide binding]; other site
868597000995	Electron transfer pathway; other site
868597000996	Subunit I/VIIIb interface [polypeptide binding]; other site
868597000997	Subunit I/VIIb interface [polypeptide binding]; other site
868597000998	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
868597000999	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
868597001000	Subunit III/VIIa interface [polypeptide binding]; other site
868597001001	Phospholipid binding site [chemical binding]; other site
868597001002	Subunit I/III interface [polypeptide binding]; other site
868597001003	Subunit III/VIb interface [polypeptide binding]; other site
868597001004	Subunit III/VIa interface; other site
868597001005	Subunit III/Vb interface [polypeptide binding]; other site
868597001006	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
868597001007	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
868597001008	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
868597001009	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
868597001010	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
868597001011	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
868597001012	UbiA prenyltransferase family; Region: UbiA; pfam01040
868597001013	Predicted membrane protein [Function unknown]; Region: COG1289
868597001014	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
868597001015	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
868597001016	Putative phosphatase (DUF442); Region: DUF442; cl17385
868597001017	DNA primase; Validated; Region: dnaG; PRK05667
868597001018	CHC2 zinc finger; Region: zf-CHC2; pfam01807
868597001019	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
868597001020	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
868597001021	active site
868597001022	metal binding site [ion binding]; metal-binding site
868597001023	interdomain interaction site; other site
868597001024	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
868597001025	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
868597001026	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
868597001027	Yqey-like protein; Region: YqeY; pfam09424
868597001028	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
868597001029	UGMP family protein; Validated; Region: PRK09604
868597001030	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
868597001031	Abi-like protein; Region: Abi_2; pfam07751
868597001032	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
868597001033	homooctamer interface [polypeptide binding]; other site
868597001034	active site
868597001035	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
868597001036	Mechanosensitive ion channel; Region: MS_channel; pfam00924
868597001037	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
868597001038	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
868597001039	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
868597001040	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
868597001041	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
868597001042	Predicted membrane protein [Function unknown]; Region: COG4682
868597001043	yiaA/B two helix domain; Region: YiaAB; pfam05360
868597001044	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
868597001045	Transposase; Region: DEDD_Tnp_IS110; pfam01548
868597001046	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
868597001047	amino acid transporter; Region: 2A0306; TIGR00909
868597001048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
868597001049	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
868597001050	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
868597001051	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
868597001052	putative active site [active]
868597001053	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
868597001054	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
868597001055	active site
868597001056	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
868597001057	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
868597001058	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
868597001059	NlpC/P60 family; Region: NLPC_P60; cl17555
868597001060	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
868597001061	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
868597001062	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
868597001063	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597001064	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597001065	Beta-lactamase; Region: Beta-lactamase; pfam00144
868597001066	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
868597001067	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
868597001068	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
868597001069	EF-hand domain pair; Region: EF_hand_5; pfam13499
868597001070	Ca2+ binding site [ion binding]; other site
868597001071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
868597001072	DinB superfamily; Region: DinB_2; pfam12867
868597001073	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
868597001074	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
868597001075	motif II; other site
868597001076	Ubiquitin-like proteins; Region: UBQ; cl00155
868597001077	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
868597001078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
868597001079	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
868597001080	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
868597001081	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
868597001082	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
868597001083	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
868597001084	metal binding triad; other site
868597001085	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
868597001086	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
868597001087	metal binding triad; other site
868597001088	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
868597001089	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
868597001090	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
868597001091	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
868597001092	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
868597001093	putative FMN binding site [chemical binding]; other site
868597001094	Uncharacterized conserved protein [Function unknown]; Region: COG2353
868597001095	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
868597001096	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
868597001097	FAD binding pocket [chemical binding]; other site
868597001098	FAD binding motif [chemical binding]; other site
868597001099	phosphate binding motif [ion binding]; other site
868597001100	NAD binding pocket [chemical binding]; other site
868597001101	Predicted transcriptional regulators [Transcription]; Region: COG1695
868597001102	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
868597001103	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
868597001104	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
868597001105	dimer interface [polypeptide binding]; other site
868597001106	TPP-binding site [chemical binding]; other site
868597001107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597001108	AAA domain; Region: AAA_21; pfam13304
868597001109	Walker A/P-loop; other site
868597001110	ATP binding site [chemical binding]; other site
868597001111	Q-loop/lid; other site
868597001112	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
868597001113	Uncharacterized conserved protein [Function unknown]; Region: COG3391
868597001114	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
868597001115	TAP-like protein; Region: Abhydrolase_4; pfam08386
868597001116	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
868597001117	NodB motif; other site
868597001118	putative active site [active]
868597001119	putative catalytic site [active]
868597001120	putative Zn binding site [ion binding]; other site
868597001121	Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521
868597001122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597001123	S-adenosylmethionine binding site [chemical binding]; other site
868597001124	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
868597001125	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
868597001126	putative metal binding site [ion binding]; other site
868597001127	putative homodimer interface [polypeptide binding]; other site
868597001128	putative homotetramer interface [polypeptide binding]; other site
868597001129	putative homodimer-homodimer interface [polypeptide binding]; other site
868597001130	putative allosteric switch controlling residues; other site
868597001131	MerC mercury resistance protein; Region: MerC; pfam03203
868597001132	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
868597001133	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
868597001134	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
868597001135	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
868597001136	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
868597001137	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597001138	Walker A/P-loop; other site
868597001139	ATP binding site [chemical binding]; other site
868597001140	Q-loop/lid; other site
868597001141	ABC transporter signature motif; other site
868597001142	Walker B; other site
868597001143	D-loop; other site
868597001144	H-loop/switch region; other site
868597001145	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
868597001146	ABC transporter; Region: ABC_tran; pfam00005
868597001147	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597001148	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597001149	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
868597001150	putative effector binding pocket; other site
868597001151	putative dimerization interface [polypeptide binding]; other site
868597001152	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
868597001153	Beta-lactamase; Region: Beta-lactamase; pfam00144
868597001154	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
868597001155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597001156	putative substrate translocation pore; other site
868597001157	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
868597001158	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
868597001159	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597001160	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
868597001161	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
868597001162	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
868597001163	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597001164	catalytic residue [active]
868597001165	NHL repeat; Region: NHL; pfam01436
868597001166	NHL repeat; Region: NHL; pfam01436
868597001167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
868597001168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
868597001169	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
868597001170	dimer interface [polypeptide binding]; other site
868597001171	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
868597001172	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
868597001173	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
868597001174	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597001175	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
868597001176	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
868597001177	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
868597001178	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
868597001179	PA/protease or protease-like domain interface [polypeptide binding]; other site
868597001180	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
868597001181	metal binding site [ion binding]; metal-binding site
868597001182	Histidine kinase; Region: His_kinase; pfam06580
868597001183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597001184	Mg2+ binding site [ion binding]; other site
868597001185	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
868597001186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597001187	active site
868597001188	phosphorylation site [posttranslational modification]
868597001189	intermolecular recognition site; other site
868597001190	dimerization interface [polypeptide binding]; other site
868597001191	LytTr DNA-binding domain; Region: LytTR; smart00850
868597001192	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
868597001193	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
868597001194	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
868597001195	active site
868597001196	Zn binding site [ion binding]; other site
868597001197	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597001198	PAS fold; Region: PAS_3; pfam08447
868597001199	putative active site [active]
868597001200	heme pocket [chemical binding]; other site
868597001201	PAS domain S-box; Region: sensory_box; TIGR00229
868597001202	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597001203	putative active site [active]
868597001204	heme pocket [chemical binding]; other site
868597001205	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597001206	metal binding site [ion binding]; metal-binding site
868597001207	active site
868597001208	I-site; other site
868597001209	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597001210	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597001211	LysR family transcriptional regulator; Provisional; Region: PRK14997
868597001212	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597001213	putative effector binding pocket; other site
868597001214	dimerization interface [polypeptide binding]; other site
868597001215	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
868597001216	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
868597001217	putative active site [active]
868597001218	metal binding site [ion binding]; metal-binding site
868597001219	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
868597001220	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
868597001221	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
868597001222	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
868597001223	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
868597001224	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
868597001225	ligand binding site [chemical binding]; other site
868597001226	flagellar motor protein MotA; Validated; Region: PRK09110
868597001227	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
868597001228	methionine sulfoxide reductase B; Provisional; Region: PRK00222
868597001229	SelR domain; Region: SelR; pfam01641
868597001230	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
868597001231	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597001232	putative DNA binding site [nucleotide binding]; other site
868597001233	putative Zn2+ binding site [ion binding]; other site
868597001234	AsnC family; Region: AsnC_trans_reg; pfam01037
868597001235	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
868597001236	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
868597001237	hydroxyglutarate oxidase; Provisional; Region: PRK11728
868597001238	alanine racemase; Reviewed; Region: alr; PRK00053
868597001239	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
868597001240	active site
868597001241	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
868597001242	substrate binding site [chemical binding]; other site
868597001243	catalytic residues [active]
868597001244	dimer interface [polypeptide binding]; other site
868597001245	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
868597001246	PAS domain; Region: PAS_9; pfam13426
868597001247	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
868597001248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597001249	putative active site [active]
868597001250	heme pocket [chemical binding]; other site
868597001251	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597001252	dimer interface [polypeptide binding]; other site
868597001253	phosphorylation site [posttranslational modification]
868597001254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597001255	ATP binding site [chemical binding]; other site
868597001256	Mg2+ binding site [ion binding]; other site
868597001257	G-X-G motif; other site
868597001258	Response regulator receiver domain; Region: Response_reg; pfam00072
868597001259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597001260	active site
868597001261	phosphorylation site [posttranslational modification]
868597001262	intermolecular recognition site; other site
868597001263	dimerization interface [polypeptide binding]; other site
868597001264	Protein of unknown function (DUF3247); Region: DUF3247; pfam11607
868597001265	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
868597001266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597001267	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
868597001268	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
868597001269	active site
868597001270	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
868597001271	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597001272	motif II; other site
868597001273	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
868597001274	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
868597001275	dimer interface [polypeptide binding]; other site
868597001276	active site
868597001277	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
868597001278	dimer interface [polypeptide binding]; other site
868597001279	active site 1 [active]
868597001280	active site 2 [active]
868597001281	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
868597001282	active site
868597001283	DNA polymerase IV; Validated; Region: PRK02406
868597001284	DNA binding site [nucleotide binding]
868597001285	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
868597001286	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
868597001287	NADH(P)-binding; Region: NAD_binding_10; pfam13460
868597001288	NAD binding site [chemical binding]; other site
868597001289	substrate binding site [chemical binding]; other site
868597001290	putative active site [active]
868597001291	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597001292	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597001293	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597001294	putative effector binding pocket; other site
868597001295	dimerization interface [polypeptide binding]; other site
868597001296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597001297	S-adenosylmethionine binding site [chemical binding]; other site
868597001298	phosphoglycolate phosphatase; Provisional; Region: PRK13222
868597001299	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
868597001300	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597001301	motif II; other site
868597001302	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
868597001303	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597001304	N-terminal plug; other site
868597001305	ligand-binding site [chemical binding]; other site
868597001306	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
868597001307	catalytic core [active]
868597001308	TfoX C-terminal domain; Region: TfoX_C; pfam04994
868597001309	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
868597001310	GAF domain; Region: GAF_2; pfam13185
868597001311	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
868597001312	AAA domain; Region: AAA_26; pfam13500
868597001313	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
868597001314	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
868597001315	DNA-binding site [nucleotide binding]; DNA binding site
868597001316	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597001317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597001318	homodimer interface [polypeptide binding]; other site
868597001319	catalytic residue [active]
868597001320	methionine sulfoxide reductase A; Provisional; Region: PRK13014
868597001321	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
868597001322	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
868597001323	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
868597001324	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
868597001325	catalytic residues [active]
868597001326	methionine sulfoxide reductase B; Provisional; Region: PRK00222
868597001327	SelR domain; Region: SelR; pfam01641
868597001328	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597001329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597001330	active site
868597001331	phosphorylation site [posttranslational modification]
868597001332	intermolecular recognition site; other site
868597001333	dimerization interface [polypeptide binding]; other site
868597001334	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597001335	DNA binding site [nucleotide binding]
868597001336	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597001337	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597001338	dimer interface [polypeptide binding]; other site
868597001339	phosphorylation site [posttranslational modification]
868597001340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597001341	ATP binding site [chemical binding]; other site
868597001342	Mg2+ binding site [ion binding]; other site
868597001343	G-X-G motif; other site
868597001344	sensor protein RstB; Provisional; Region: PRK10604
868597001345	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
868597001346	dimerization interface [polypeptide binding]; other site
868597001347	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597001348	dimer interface [polypeptide binding]; other site
868597001349	phosphorylation site [posttranslational modification]
868597001350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597001351	ATP binding site [chemical binding]; other site
868597001352	G-X-G motif; other site
868597001353	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
868597001354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597001355	active site
868597001356	phosphorylation site [posttranslational modification]
868597001357	intermolecular recognition site; other site
868597001358	dimerization interface [polypeptide binding]; other site
868597001359	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597001360	DNA binding site [nucleotide binding]
868597001361	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
868597001362	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
868597001363	active site
868597001364	dimer interface [polypeptide binding]; other site
868597001365	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
868597001366	Ligand Binding Site [chemical binding]; other site
868597001367	Molecular Tunnel; other site
868597001368	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
868597001369	active site
868597001370	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597001371	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
868597001372	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597001373	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
868597001374	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
868597001375	putative active site [active]
868597001376	Zn binding site [ion binding]; other site
868597001377	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
868597001378	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
868597001379	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
868597001380	ATP binding site [chemical binding]; other site
868597001381	Mg++ binding site [ion binding]; other site
868597001382	motif III; other site
868597001383	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597001384	nucleotide binding region [chemical binding]; other site
868597001385	ATP-binding site [chemical binding]; other site
868597001386	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
868597001387	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
868597001388	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
868597001389	maleylacetoacetate isomerase; Region: maiA; TIGR01262
868597001390	C-terminal domain interface [polypeptide binding]; other site
868597001391	GSH binding site (G-site) [chemical binding]; other site
868597001392	putative dimer interface [polypeptide binding]; other site
868597001393	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
868597001394	dimer interface [polypeptide binding]; other site
868597001395	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
868597001396	N-terminal domain interface [polypeptide binding]; other site
868597001397	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
868597001398	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
868597001399	Fe-S cluster binding site [ion binding]; other site
868597001400	active site
868597001401	Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277
868597001402	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
868597001403	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
868597001404	ATP binding site [chemical binding]; other site
868597001405	Walker B motif; other site
868597001406	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
868597001407	Protein of unknown function (DUF465); Region: DUF465; pfam04325
868597001408	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
868597001409	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
868597001410	dimer interface [polypeptide binding]; other site
868597001411	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597001412	catalytic residue [active]
868597001413	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
868597001414	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
868597001415	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
868597001416	homodimer interface [polypeptide binding]; other site
868597001417	substrate-cofactor binding pocket; other site
868597001418	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597001419	catalytic residue [active]
868597001420	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
868597001421	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
868597001422	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
868597001423	trimer interface [polypeptide binding]; other site
868597001424	active site
868597001425	substrate binding site [chemical binding]; other site
868597001426	CoA binding site [chemical binding]; other site
868597001427	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
868597001428	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
868597001429	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
868597001430	Walker A/P-loop; other site
868597001431	ATP binding site [chemical binding]; other site
868597001432	Q-loop/lid; other site
868597001433	ABC transporter signature motif; other site
868597001434	Walker B; other site
868597001435	D-loop; other site
868597001436	H-loop/switch region; other site
868597001437	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
868597001438	putative carbohydrate binding site [chemical binding]; other site
868597001439	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
868597001440	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
868597001441	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
868597001442	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
868597001443	Probable Catalytic site; other site
868597001444	metal-binding site
868597001445	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
868597001446	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
868597001447	extended (e) SDRs; Region: SDR_e; cd08946
868597001448	NAD(P) binding site [chemical binding]; other site
868597001449	active site
868597001450	substrate binding site [chemical binding]; other site
868597001451	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
868597001452	hypothetical protein; Validated; Region: PRK08238
868597001453	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
868597001454	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
868597001455	Sulfatase; Region: Sulfatase; cl17466
868597001456	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
868597001457	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
868597001458	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
868597001459	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
868597001460	Ligand binding site [chemical binding]; other site
868597001461	Electron transfer flavoprotein domain; Region: ETF; pfam01012
868597001462	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
868597001463	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
868597001464	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
868597001465	NAD binding site [chemical binding]; other site
868597001466	substrate binding site [chemical binding]; other site
868597001467	homodimer interface [polypeptide binding]; other site
868597001468	active site
868597001469	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
868597001470	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
868597001471	substrate binding site; other site
868597001472	tetramer interface; other site
868597001473	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
868597001474	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
868597001475	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
868597001476	NADP binding site [chemical binding]; other site
868597001477	active site
868597001478	putative substrate binding site [chemical binding]; other site
868597001479	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
868597001480	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
868597001481	Substrate binding site; other site
868597001482	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
868597001483	phosphomannomutase CpsG; Provisional; Region: PRK15414
868597001484	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
868597001485	active site
868597001486	substrate binding site [chemical binding]; other site
868597001487	metal binding site [ion binding]; metal-binding site
868597001488	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
868597001489	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
868597001490	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
868597001491	putative ligand binding site [chemical binding]; other site
868597001492	putative catalytic site [active]
868597001493	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
868597001494	Protein of unknown function (DUF330); Region: DUF330; cl01135
868597001495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
868597001496	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
868597001497	mce related protein; Region: MCE; pfam02470
868597001498	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
868597001499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597001500	Walker A/P-loop; other site
868597001501	ATP binding site [chemical binding]; other site
868597001502	Q-loop/lid; other site
868597001503	ABC transporter signature motif; other site
868597001504	Walker B; other site
868597001505	D-loop; other site
868597001506	H-loop/switch region; other site
868597001507	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
868597001508	Permease; Region: Permease; pfam02405
868597001509	Uncharacterized conserved protein [Function unknown]; Region: COG2966
868597001510	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
868597001511	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
868597001512	H-NS histone family; Region: Histone_HNS; pfam00816
868597001513	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
868597001514	prolyl-tRNA synthetase; Provisional; Region: PRK09194
868597001515	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
868597001516	dimer interface [polypeptide binding]; other site
868597001517	motif 1; other site
868597001518	active site
868597001519	motif 2; other site
868597001520	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
868597001521	putative deacylase active site [active]
868597001522	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
868597001523	active site
868597001524	motif 3; other site
868597001525	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
868597001526	anticodon binding site; other site
868597001527	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
868597001528	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
868597001529	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
868597001530	DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436
868597001531	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
868597001532	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
868597001533	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
868597001534	EamA-like transporter family; Region: EamA; pfam00892
868597001535	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
868597001536	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
868597001537	active site
868597001538	HIGH motif; other site
868597001539	nucleotide binding site [chemical binding]; other site
868597001540	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
868597001541	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
868597001542	active site
868597001543	KMSKS motif; other site
868597001544	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
868597001545	tRNA binding surface [nucleotide binding]; other site
868597001546	anticodon binding site; other site
868597001547	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
868597001548	DNA polymerase III subunit chi; Validated; Region: PRK05728
868597001549	multifunctional aminopeptidase A; Provisional; Region: PRK00913
868597001550	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
868597001551	interface (dimer of trimers) [polypeptide binding]; other site
868597001552	Substrate-binding/catalytic site; other site
868597001553	Zn-binding sites [ion binding]; other site
868597001554	Predicted permeases [General function prediction only]; Region: COG0795
868597001555	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
868597001556	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
868597001557	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
868597001558	RDD family; Region: RDD; pfam06271
868597001559	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
868597001560	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
868597001561	active site
868597001562	DNA binding site [nucleotide binding]
868597001563	Int/Topo IB signature motif; other site
868597001564	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
868597001565	dimerization domain [polypeptide binding]; other site
868597001566	dimer interface [polypeptide binding]; other site
868597001567	catalytic residues [active]
868597001568	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
868597001569	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
868597001570	Interdomain contacts; other site
868597001571	Glyco_18 domain; Region: Glyco_18; smart00636
868597001572	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
868597001573	active site
868597001574	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
868597001575	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
868597001576	dimerization interface [polypeptide binding]; other site
868597001577	ATP binding site [chemical binding]; other site
868597001578	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
868597001579	dimerization interface [polypeptide binding]; other site
868597001580	ATP binding site [chemical binding]; other site
868597001581	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
868597001582	putative active site [active]
868597001583	catalytic triad [active]
868597001584	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
868597001585	trimer interface [polypeptide binding]; other site
868597001586	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
868597001587	trimer interface [polypeptide binding]; other site
868597001588	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
868597001589	trimer interface [polypeptide binding]; other site
868597001590	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
868597001591	trimer interface [polypeptide binding]; other site
868597001592	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
868597001593	trimer interface [polypeptide binding]; other site
868597001594	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
868597001595	trimer interface [polypeptide binding]; other site
868597001596	Haemagglutinin; Region: HIM; pfam05662
868597001597	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
868597001598	active site
868597001599	catalytic triad [active]
868597001600	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
868597001601	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
868597001602	type II secretion system protein E; Region: type_II_gspE; TIGR02533
868597001603	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
868597001604	Walker A motif; other site
868597001605	ATP binding site [chemical binding]; other site
868597001606	Walker B motif; other site
868597001607	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
868597001608	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597001609	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597001610	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
868597001611	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
868597001612	general secretion pathway protein J; Validated; Region: PRK08808
868597001613	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
868597001614	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
868597001615	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
868597001616	type II secretion system protein D; Region: type_II_gspD; TIGR02517
868597001617	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
868597001618	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
868597001619	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
868597001620	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
868597001621	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
868597001622	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
868597001623	Probable Catalytic site; other site
868597001624	metal-binding site
868597001625	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
868597001626	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
868597001627	active site
868597001628	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
868597001629	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
868597001630	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
868597001631	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
868597001632	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
868597001633	PapC N-terminal domain; Region: PapC_N; pfam13954
868597001634	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
868597001635	PapC C-terminal domain; Region: PapC_C; pfam13953
868597001636	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
868597001637	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
868597001638	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
868597001639	active site
868597001640	homodimer interface [polypeptide binding]; other site
868597001641	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
868597001642	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
868597001643	active site
868597001644	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
868597001645	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
868597001646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
868597001647	binding surface
868597001648	TPR motif; other site
868597001649	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
868597001650	hypothetical protein; Provisional; Region: PRK09936
868597001651	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
868597001652	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
868597001653	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
868597001654	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
868597001655	ABC transporter; Region: ABC_tran_2; pfam12848
868597001656	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
868597001657	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
868597001658	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
868597001659	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
868597001660	dimer interface [polypeptide binding]; other site
868597001661	active site
868597001662	glycine-pyridoxal phosphate binding site [chemical binding]; other site
868597001663	folate binding site [chemical binding]; other site
868597001664	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
868597001665	ATP cone domain; Region: ATP-cone; pfam03477
868597001666	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
868597001667	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
868597001668	catalytic motif [active]
868597001669	Zn binding site [ion binding]; other site
868597001670	RibD C-terminal domain; Region: RibD_C; cl17279
868597001671	sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273
868597001672	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
868597001673	Lumazine binding domain; Region: Lum_binding; pfam00677
868597001674	Lumazine binding domain; Region: Lum_binding; pfam00677
868597001675	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
868597001676	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
868597001677	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
868597001678	dimerization interface [polypeptide binding]; other site
868597001679	active site
868597001680	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
868597001681	homopentamer interface [polypeptide binding]; other site
868597001682	active site
868597001683	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
868597001684	putative RNA binding site [nucleotide binding]; other site
868597001685	thiamine monophosphate kinase; Provisional; Region: PRK05731
868597001686	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
868597001687	ATP binding site [chemical binding]; other site
868597001688	dimerization interface [polypeptide binding]; other site
868597001689	Protein of unknown function (DUF805); Region: DUF805; pfam05656
868597001690	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
868597001691	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
868597001692	Autotransporter beta-domain; Region: Autotransporter; smart00869
868597001693	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
868597001694	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
868597001695	Autotransporter beta-domain; Region: Autotransporter; pfam03797
868597001696	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
868597001697	FAD binding domain; Region: FAD_binding_4; pfam01565
868597001698	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
868597001699	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
868597001700	hypothetical protein; Reviewed; Region: PRK12497
868597001701	LppC putative lipoprotein; Region: LppC; pfam04348
868597001702	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
868597001703	putative ligand binding site [chemical binding]; other site
868597001704	Predicted methyltransferases [General function prediction only]; Region: COG0313
868597001705	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
868597001706	putative SAM binding site [chemical binding]; other site
868597001707	putative homodimer interface [polypeptide binding]; other site
868597001708	Electron transfer DM13; Region: DM13; pfam10517
868597001709	NRDE protein; Region: NRDE; pfam05742
868597001710	cell division protein MraZ; Reviewed; Region: PRK00326
868597001711	MraZ protein; Region: MraZ; pfam02381
868597001712	MraZ protein; Region: MraZ; pfam02381
868597001713	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
868597001714	MraW methylase family; Region: Methyltransf_5; cl17771
868597001715	Cell division protein FtsL; Region: FtsL; pfam04999
868597001716	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
868597001717	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
868597001718	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
868597001719	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
868597001720	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
868597001721	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
868597001722	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
868597001723	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
868597001724	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
868597001725	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
868597001726	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
868597001727	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
868597001728	Mg++ binding site [ion binding]; other site
868597001729	putative catalytic motif [active]
868597001730	putative substrate binding site [chemical binding]; other site
868597001731	cell division protein FtsW; Region: ftsW; TIGR02614
868597001732	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
868597001733	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
868597001734	active site
868597001735	homodimer interface [polypeptide binding]; other site
868597001736	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
868597001737	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
868597001738	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
868597001739	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
868597001740	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
868597001741	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
868597001742	ATP-grasp domain; Region: ATP-grasp_4; cl17255
868597001743	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
868597001744	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
868597001745	Cell division protein FtsQ; Region: FtsQ; pfam03799
868597001746	cell division protein FtsA; Region: ftsA; TIGR01174
868597001747	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
868597001748	nucleotide binding site [chemical binding]; other site
868597001749	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
868597001750	Cell division protein FtsA; Region: FtsA; pfam14450
868597001751	cell division protein FtsZ; Validated; Region: PRK09330
868597001752	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
868597001753	nucleotide binding site [chemical binding]; other site
868597001754	SulA interaction site; other site
868597001755	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
868597001756	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
868597001757	Protein of unknown function (DUF721); Region: DUF721; cl02324
868597001758	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
868597001759	Peptidase family M23; Region: Peptidase_M23; pfam01551
868597001760	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
868597001761	DEAD/DEAH box helicase; Region: DEAD; pfam00270
868597001762	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
868597001763	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
868597001764	nucleotide binding region [chemical binding]; other site
868597001765	ATP-binding site [chemical binding]; other site
868597001766	SEC-C motif; Region: SEC-C; pfam02810
868597001767	hypothetical protein; Provisional; Region: PRK08999
868597001768	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
868597001769	active site
868597001770	8-oxo-dGMP binding site [chemical binding]; other site
868597001771	nudix motif; other site
868597001772	metal binding site [ion binding]; metal-binding site
868597001773	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
868597001774	thiamine phosphate binding site [chemical binding]; other site
868597001775	active site
868597001776	pyrophosphate binding site [ion binding]; other site
868597001777	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
868597001778	FAD binding site [chemical binding]; other site
868597001779	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
868597001780	Histidine kinase; Region: His_kinase; pfam06580
868597001781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
868597001782	Mg2+ binding site [ion binding]; other site
868597001783	G-X-G motif; other site
868597001784	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
868597001785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597001786	active site
868597001787	phosphorylation site [posttranslational modification]
868597001788	intermolecular recognition site; other site
868597001789	LytTr DNA-binding domain; Region: LytTR; smart00850
868597001790	Amidohydrolase; Region: Amidohydro_5; pfam13594
868597001791	Amidohydrolase; Region: Amidohydro_4; pfam13147
868597001792	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
868597001793	Protein of unknown function (DUF3228); Region: DUF3228; pfam11539
868597001794	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597001795	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
868597001796	putative deacylase active site [active]
868597001797	Adenosylhomocysteinase; Provisional; Region: PTZ00075
868597001798	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
868597001799	homotetramer interface [polypeptide binding]; other site
868597001800	ligand binding site [chemical binding]; other site
868597001801	catalytic site [active]
868597001802	NAD binding site [chemical binding]; other site
868597001803	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
868597001804	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597001805	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
868597001806	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
868597001807	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
868597001808	S-adenosylmethionine synthetase; Validated; Region: PRK05250
868597001809	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
868597001810	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
868597001811	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
868597001812	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
868597001813	putative acyl-acceptor binding pocket; other site
868597001814	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
868597001815	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
868597001816	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
868597001817	putative active site [active]
868597001818	putative metal binding site [ion binding]; other site
868597001819	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
868597001820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597001821	S-adenosylmethionine binding site [chemical binding]; other site
868597001822	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
868597001823	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
868597001824	FMN binding site [chemical binding]; other site
868597001825	active site
868597001826	catalytic residues [active]
868597001827	substrate binding site [chemical binding]; other site
868597001828	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
868597001829	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
868597001830	substrate binding site [chemical binding]; other site
868597001831	dimer interface [polypeptide binding]; other site
868597001832	ATP binding site [chemical binding]; other site
868597001833	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
868597001834	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
868597001835	Nucleoside recognition; Region: Gate; pfam07670
868597001836	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
868597001837	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
868597001838	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
868597001839	active site
868597001840	catalytic tetrad [active]
868597001841	Hemin uptake protein hemP; Region: hemP; pfam10636
868597001842	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
868597001843	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597001844	N-terminal plug; other site
868597001845	ligand-binding site [chemical binding]; other site
868597001846	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
868597001847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169
868597001848	FtsX-like permease family; Region: FtsX; pfam02687
868597001849	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
868597001850	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
868597001851	Walker A/P-loop; other site
868597001852	ATP binding site [chemical binding]; other site
868597001853	Q-loop/lid; other site
868597001854	ABC transporter signature motif; other site
868597001855	Walker B; other site
868597001856	D-loop; other site
868597001857	H-loop/switch region; other site
868597001858	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
868597001859	active site
868597001860	catalytic triad [active]
868597001861	oxyanion hole [active]
868597001862	switch loop; other site
868597001863	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597001864	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597001865	active site
868597001866	phosphorylation site [posttranslational modification]
868597001867	intermolecular recognition site; other site
868597001868	dimerization interface [polypeptide binding]; other site
868597001869	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597001870	DNA binding site [nucleotide binding]
868597001871	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597001872	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597001873	dimer interface [polypeptide binding]; other site
868597001874	phosphorylation site [posttranslational modification]
868597001875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597001876	ATP binding site [chemical binding]; other site
868597001877	Mg2+ binding site [ion binding]; other site
868597001878	G-X-G motif; other site
868597001879	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502
868597001880	active site
868597001881	catalytic triad [active]
868597001882	oxyanion hole [active]
868597001883	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
868597001884	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
868597001885	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
868597001886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597001887	putative substrate translocation pore; other site
868597001888	LemA family; Region: LemA; pfam04011
868597001889	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
868597001890	Repair protein; Region: Repair_PSII; pfam04536
868597001891	Repair protein; Region: Repair_PSII; pfam04536
868597001892	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
868597001893	thymidylate synthase; Reviewed; Region: thyA; PRK01827
868597001894	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
868597001895	dimerization interface [polypeptide binding]; other site
868597001896	active site
868597001897	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
868597001898	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
868597001899	folate binding site [chemical binding]; other site
868597001900	NADP+ binding site [chemical binding]; other site
868597001901	Domain of unknown function (DUF1287); Region: DUF1287; pfam06940
868597001902	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
868597001903	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
868597001904	active site
868597001905	metal binding site [ion binding]; metal-binding site
868597001906	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
868597001907	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
868597001908	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
868597001909	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
868597001910	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
868597001911	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
868597001912	SurA N-terminal domain; Region: SurA_N; pfam09312
868597001913	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
868597001914	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
868597001915	organic solvent tolerance protein; Provisional; Region: PRK04423
868597001916	Organic solvent tolerance protein; Region: OstA_C; pfam04453
868597001917	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
868597001918	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
868597001919	putative active site [active]
868597001920	Zn binding site [ion binding]; other site
868597001921	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
868597001922	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
868597001923	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
868597001924	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Validated; Region: PRK08773
868597001925	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
868597001926	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
868597001927	pseudo EF-hand loop; other site
868597001928	peptide binding pocket; other site
868597001929	Ca2+ binding site [ion binding]; other site
868597001930	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
868597001931	FtsJ-like methyltransferase; Region: FtsJ; cl17430
868597001932	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
868597001933	nucleoside/Zn binding site; other site
868597001934	dimer interface [polypeptide binding]; other site
868597001935	catalytic motif [active]
868597001936	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
868597001937	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
868597001938	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
868597001939	active site
868597001940	HIGH motif; other site
868597001941	nucleotide binding site [chemical binding]; other site
868597001942	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
868597001943	active site
868597001944	KMSKS motif; other site
868597001945	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
868597001946	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
868597001947	methionine sulfoxide reductase A; Provisional; Region: PRK00058
868597001948	transaldolase-like protein; Provisional; Region: PTZ00411
868597001949	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
868597001950	active site
868597001951	dimer interface [polypeptide binding]; other site
868597001952	catalytic residue [active]
868597001953	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
868597001954	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
868597001955	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
868597001956	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597001957	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
868597001958	dimerization interface [polypeptide binding]; other site
868597001959	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
868597001960	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
868597001961	catalytic residue [active]
868597001962	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
868597001963	catalytic residues [active]
868597001964	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
868597001965	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
868597001966	peroxiredoxin; Region: AhpC; TIGR03137
868597001967	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
868597001968	dimer interface [polypeptide binding]; other site
868597001969	decamer (pentamer of dimers) interface [polypeptide binding]; other site
868597001970	catalytic triad [active]
868597001971	peroxidatic and resolving cysteines [active]
868597001972	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
868597001973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597001974	S-adenosylmethionine binding site [chemical binding]; other site
868597001975	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
868597001976	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597001977	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597001978	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597001979	putative effector binding pocket; other site
868597001980	dimerization interface [polypeptide binding]; other site
868597001981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597001982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597001983	N-formylglutamate amidohydrolase; Region: FGase; cl01522
868597001984	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
868597001985	ADP-ribose binding site [chemical binding]; other site
868597001986	dimer interface [polypeptide binding]; other site
868597001987	active site
868597001988	nudix motif; other site
868597001989	metal binding site [ion binding]; metal-binding site
868597001990	5'-3' exonuclease; Region: 53EXOc; smart00475
868597001991	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
868597001992	active site
868597001993	metal binding site 1 [ion binding]; metal-binding site
868597001994	putative 5' ssDNA interaction site; other site
868597001995	metal binding site 3; metal-binding site
868597001996	metal binding site 2 [ion binding]; metal-binding site
868597001997	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
868597001998	putative DNA binding site [nucleotide binding]; other site
868597001999	putative metal binding site [ion binding]; other site
868597002000	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
868597002001	putative FMN binding site [chemical binding]; other site
868597002002	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
868597002003	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
868597002004	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
868597002005	ligand binding site [chemical binding]; other site
868597002006	homodimer interface [polypeptide binding]; other site
868597002007	NAD(P) binding site [chemical binding]; other site
868597002008	trimer interface B [polypeptide binding]; other site
868597002009	trimer interface A [polypeptide binding]; other site
868597002010	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
868597002011	RNA polymerase factor sigma-70; Validated; Region: PRK09047
868597002012	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597002013	DNA binding residues [nucleotide binding]
868597002014	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
868597002015	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
868597002016	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
868597002017	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
868597002018	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
868597002019	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
868597002020	homodimer interface [polypeptide binding]; other site
868597002021	substrate-cofactor binding pocket; other site
868597002022	catalytic residue [active]
868597002023	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
868597002024	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
868597002025	Peptidase family M23; Region: Peptidase_M23; pfam01551
868597002026	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
868597002027	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
868597002028	active site
868597002029	catalytic triad [active]
868597002030	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
868597002031	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
868597002032	active site
868597002033	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
868597002034	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597002035	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
868597002036	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
868597002037	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
868597002038	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
868597002039	catalytic residues [active]
868597002040	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
868597002041	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597002042	TPR motif; other site
868597002043	binding surface
868597002044	Tetratricopeptide repeat; Region: TPR_16; pfam13432
868597002045	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
868597002046	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
868597002047	peptide chain release factor 1; Validated; Region: prfA; PRK00591
868597002048	This domain is found in peptide chain release factors; Region: PCRF; smart00937
868597002049	RF-1 domain; Region: RF-1; pfam00472
868597002050	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
868597002051	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
868597002052	tRNA; other site
868597002053	putative tRNA binding site [nucleotide binding]; other site
868597002054	putative NADP binding site [chemical binding]; other site
868597002055	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
868597002056	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
868597002057	binding surface
868597002058	TPR motif; other site
868597002059	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597002060	TPR motif; other site
868597002061	binding surface
868597002062	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
868597002063	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597002064	binding surface
868597002065	TPR motif; other site
868597002066	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
868597002067	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
868597002068	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
868597002069	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923
868597002070	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
868597002071	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
868597002072	active site
868597002073	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
868597002074	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
868597002075	5S rRNA interface [nucleotide binding]; other site
868597002076	CTC domain interface [polypeptide binding]; other site
868597002077	L16 interface [polypeptide binding]; other site
868597002078	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
868597002079	putative active site [active]
868597002080	catalytic residue [active]
868597002081	GTP-binding protein YchF; Reviewed; Region: PRK09601
868597002082	YchF GTPase; Region: YchF; cd01900
868597002083	G1 box; other site
868597002084	GTP/Mg2+ binding site [chemical binding]; other site
868597002085	Switch I region; other site
868597002086	G2 box; other site
868597002087	Switch II region; other site
868597002088	G3 box; other site
868597002089	G4 box; other site
868597002090	G5 box; other site
868597002091	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
868597002092	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
868597002093	Autotransporter beta-domain; Region: Autotransporter; pfam03797
868597002094	transcriptional regulator RcsB; Provisional; Region: PRK10840
868597002095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597002096	active site
868597002097	phosphorylation site [posttranslational modification]
868597002098	intermolecular recognition site; other site
868597002099	dimerization interface [polypeptide binding]; other site
868597002100	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597002101	DNA binding residues [nucleotide binding]
868597002102	dimerization interface [polypeptide binding]; other site
868597002103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597002104	dimer interface [polypeptide binding]; other site
868597002105	phosphorylation site [posttranslational modification]
868597002106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597002107	ATP binding site [chemical binding]; other site
868597002108	Mg2+ binding site [ion binding]; other site
868597002109	G-X-G motif; other site
868597002110	Response regulator receiver domain; Region: Response_reg; pfam00072
868597002111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597002112	active site
868597002113	phosphorylation site [posttranslational modification]
868597002114	intermolecular recognition site; other site
868597002115	dimerization interface [polypeptide binding]; other site
868597002116	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
868597002117	putative binding surface; other site
868597002118	active site
868597002119	Response regulator receiver domain; Region: Response_reg; pfam00072
868597002120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597002121	active site
868597002122	phosphorylation site [posttranslational modification]
868597002123	intermolecular recognition site; other site
868597002124	dimerization interface [polypeptide binding]; other site
868597002125	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597002126	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597002127	dimer interface [polypeptide binding]; other site
868597002128	phosphorylation site [posttranslational modification]
868597002129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597002130	ATP binding site [chemical binding]; other site
868597002131	Mg2+ binding site [ion binding]; other site
868597002132	G-X-G motif; other site
868597002133	Response regulator receiver domain; Region: Response_reg; pfam00072
868597002134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597002135	active site
868597002136	phosphorylation site [posttranslational modification]
868597002137	intermolecular recognition site; other site
868597002138	dimerization interface [polypeptide binding]; other site
868597002139	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597002140	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
868597002141	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597002142	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
868597002143	proposed catalytic triad [active]
868597002144	active site nucleophile [active]
868597002145	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
868597002146	catalytic nucleophile [active]
868597002147	elongation factor Tu; Reviewed; Region: PRK00049
868597002148	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
868597002149	G1 box; other site
868597002150	GEF interaction site [polypeptide binding]; other site
868597002151	GTP/Mg2+ binding site [chemical binding]; other site
868597002152	Switch I region; other site
868597002153	G2 box; other site
868597002154	G3 box; other site
868597002155	Switch II region; other site
868597002156	G4 box; other site
868597002157	G5 box; other site
868597002158	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
868597002159	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
868597002160	Antibiotic Binding Site [chemical binding]; other site
868597002161	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
868597002162	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
868597002163	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
868597002164	putative homodimer interface [polypeptide binding]; other site
868597002165	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
868597002166	heterodimer interface [polypeptide binding]; other site
868597002167	homodimer interface [polypeptide binding]; other site
868597002168	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
868597002169	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
868597002170	23S rRNA interface [nucleotide binding]; other site
868597002171	L7/L12 interface [polypeptide binding]; other site
868597002172	putative thiostrepton binding site; other site
868597002173	L25 interface [polypeptide binding]; other site
868597002174	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
868597002175	mRNA/rRNA interface [nucleotide binding]; other site
868597002176	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
868597002177	23S rRNA interface [nucleotide binding]; other site
868597002178	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
868597002179	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
868597002180	core dimer interface [polypeptide binding]; other site
868597002181	peripheral dimer interface [polypeptide binding]; other site
868597002182	L10 interface [polypeptide binding]; other site
868597002183	L11 interface [polypeptide binding]; other site
868597002184	putative EF-Tu interaction site [polypeptide binding]; other site
868597002185	putative EF-G interaction site [polypeptide binding]; other site
868597002186	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
868597002187	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
868597002188	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
868597002189	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
868597002190	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
868597002191	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
868597002192	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
868597002193	RPB3 interaction site [polypeptide binding]; other site
868597002194	RPB1 interaction site [polypeptide binding]; other site
868597002195	RPB11 interaction site [polypeptide binding]; other site
868597002196	RPB10 interaction site [polypeptide binding]; other site
868597002197	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
868597002198	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
868597002199	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
868597002200	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
868597002201	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
868597002202	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
868597002203	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
868597002204	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
868597002205	DNA binding site [nucleotide binding]
868597002206	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
868597002207	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
868597002208	S17 interaction site [polypeptide binding]; other site
868597002209	S8 interaction site; other site
868597002210	16S rRNA interaction site [nucleotide binding]; other site
868597002211	streptomycin interaction site [chemical binding]; other site
868597002212	23S rRNA interaction site [nucleotide binding]; other site
868597002213	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
868597002214	30S ribosomal protein S7; Validated; Region: PRK05302
868597002215	elongation factor G; Reviewed; Region: PRK00007
868597002216	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
868597002217	G1 box; other site
868597002218	putative GEF interaction site [polypeptide binding]; other site
868597002219	GTP/Mg2+ binding site [chemical binding]; other site
868597002220	Switch I region; other site
868597002221	G2 box; other site
868597002222	G3 box; other site
868597002223	Switch II region; other site
868597002224	G4 box; other site
868597002225	G5 box; other site
868597002226	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
868597002227	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
868597002228	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
868597002229	elongation factor Tu; Reviewed; Region: PRK00049
868597002230	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
868597002231	G1 box; other site
868597002232	GEF interaction site [polypeptide binding]; other site
868597002233	GTP/Mg2+ binding site [chemical binding]; other site
868597002234	Switch I region; other site
868597002235	G2 box; other site
868597002236	G3 box; other site
868597002237	Switch II region; other site
868597002238	G4 box; other site
868597002239	G5 box; other site
868597002240	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
868597002241	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
868597002242	Antibiotic Binding Site [chemical binding]; other site
868597002243	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
868597002244	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
868597002245	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
868597002246	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
868597002247	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
868597002248	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
868597002249	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
868597002250	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
868597002251	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
868597002252	putative translocon binding site; other site
868597002253	protein-rRNA interface [nucleotide binding]; other site
868597002254	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
868597002255	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
868597002256	G-X-X-G motif; other site
868597002257	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
868597002258	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
868597002259	23S rRNA interface [nucleotide binding]; other site
868597002260	5S rRNA interface [nucleotide binding]; other site
868597002261	putative antibiotic binding site [chemical binding]; other site
868597002262	L25 interface [polypeptide binding]; other site
868597002263	L27 interface [polypeptide binding]; other site
868597002264	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
868597002265	putative translocon interaction site; other site
868597002266	23S rRNA interface [nucleotide binding]; other site
868597002267	signal recognition particle (SRP54) interaction site; other site
868597002268	L23 interface [polypeptide binding]; other site
868597002269	trigger factor interaction site; other site
868597002270	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
868597002271	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
868597002272	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
868597002273	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
868597002274	RNA binding site [nucleotide binding]; other site
868597002275	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
868597002276	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
868597002277	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
868597002278	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
868597002279	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
868597002280	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
868597002281	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
868597002282	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
868597002283	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
868597002284	5S rRNA interface [nucleotide binding]; other site
868597002285	23S rRNA interface [nucleotide binding]; other site
868597002286	L5 interface [polypeptide binding]; other site
868597002287	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
868597002288	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
868597002289	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
868597002290	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
868597002291	23S rRNA binding site [nucleotide binding]; other site
868597002292	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
868597002293	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
868597002294	SecY translocase; Region: SecY; pfam00344
868597002295	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
868597002296	30S ribosomal protein S13; Region: bact_S13; TIGR03631
868597002297	30S ribosomal protein S11; Validated; Region: PRK05309
868597002298	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
868597002299	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
868597002300	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597002301	RNA binding surface [nucleotide binding]; other site
868597002302	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
868597002303	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
868597002304	alphaNTD homodimer interface [polypeptide binding]; other site
868597002305	alphaNTD - beta interaction site [polypeptide binding]; other site
868597002306	alphaNTD - beta' interaction site [polypeptide binding]; other site
868597002307	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
868597002308	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
868597002309	disulfide bond formation protein B; Provisional; Region: PRK04388
868597002310	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597002311	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597002312	N-terminal plug; other site
868597002313	ligand-binding site [chemical binding]; other site
868597002314	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
868597002315	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
868597002316	Mechanosensitive ion channel; Region: MS_channel; pfam00924
868597002317	amidase; Provisional; Region: PRK08137
868597002318	Amidase; Region: Amidase; cl11426
868597002319	Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900
868597002320	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
868597002321	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
868597002322	G1 box; other site
868597002323	putative GEF interaction site [polypeptide binding]; other site
868597002324	GTP/Mg2+ binding site [chemical binding]; other site
868597002325	Switch I region; other site
868597002326	G2 box; other site
868597002327	G3 box; other site
868597002328	Switch II region; other site
868597002329	G4 box; other site
868597002330	G5 box; other site
868597002331	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
868597002332	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
868597002333	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
868597002334	active site
868597002335	malate dehydrogenase; Provisional; Region: PRK05442
868597002336	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
868597002337	NAD(P) binding site [chemical binding]; other site
868597002338	dimer interface [polypeptide binding]; other site
868597002339	malate binding site [chemical binding]; other site
868597002340	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
868597002341	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
868597002342	active site
868597002343	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
868597002344	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
868597002345	acyl-activating enzyme (AAE) consensus motif; other site
868597002346	AMP binding site [chemical binding]; other site
868597002347	active site
868597002348	CoA binding site [chemical binding]; other site
868597002349	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
868597002350	glutathionine S-transferase; Provisional; Region: PRK10542
868597002351	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
868597002352	C-terminal domain interface [polypeptide binding]; other site
868597002353	GSH binding site (G-site) [chemical binding]; other site
868597002354	dimer interface [polypeptide binding]; other site
868597002355	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
868597002356	dimer interface [polypeptide binding]; other site
868597002357	N-terminal domain interface [polypeptide binding]; other site
868597002358	substrate binding pocket (H-site) [chemical binding]; other site
868597002359	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
868597002360	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
868597002361	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
868597002362	active site
868597002363	FMN binding site [chemical binding]; other site
868597002364	2,4-decadienoyl-CoA binding site; other site
868597002365	catalytic residue [active]
868597002366	4Fe-4S cluster binding site [ion binding]; other site
868597002367	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
868597002368	Predicted membrane protein [Function unknown]; Region: COG2364
868597002369	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
868597002370	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
868597002371	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
868597002372	putative NAD(P) binding site [chemical binding]; other site
868597002373	Enoylreductase; Region: PKS_ER; smart00829
868597002374	dimer interface [polypeptide binding]; other site
868597002375	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
868597002376	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
868597002377	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
868597002378	ligand binding site [chemical binding]; other site
868597002379	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597002380	RNA binding surface [nucleotide binding]; other site
868597002381	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
868597002382	pseudouridine synthase; Region: TIGR00093
868597002383	active site
868597002384	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
868597002385	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
868597002386	substrate-cofactor binding pocket; other site
868597002387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597002388	catalytic residue [active]
868597002389	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
868597002390	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
868597002391	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
868597002392	NAD(P) binding site [chemical binding]; other site
868597002393	Peptidase S46; Region: Peptidase_S46; pfam10459
868597002394	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
868597002395	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
868597002396	catalytic core [active]
868597002397	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
868597002398	Sporulation related domain; Region: SPOR; pfam05036
868597002399	Sporulation related domain; Region: SPOR; pfam05036
868597002400	Colicin V production protein; Region: Colicin_V; pfam02674
868597002401	amidophosphoribosyltransferase; Provisional; Region: PRK09246
868597002402	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
868597002403	active site
868597002404	tetramer interface [polypeptide binding]; other site
868597002405	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
868597002406	active site
868597002407	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
868597002408	dinuclear metal binding motif [ion binding]; other site
868597002409	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
868597002410	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
868597002411	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
868597002412	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
868597002413	putative active site [active]
868597002414	putative metal binding site [ion binding]; other site
868597002415	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
868597002416	active site
868597002417	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
868597002418	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
868597002419	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597002420	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597002421	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597002422	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597002423	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
868597002424	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
868597002425	polyphosphate kinase; Provisional; Region: PRK05443
868597002426	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
868597002427	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
868597002428	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
868597002429	putative active site [active]
868597002430	catalytic site [active]
868597002431	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
868597002432	putative domain interface [polypeptide binding]; other site
868597002433	putative active site [active]
868597002434	catalytic site [active]
868597002435	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
868597002436	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
868597002437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597002438	dimer interface [polypeptide binding]; other site
868597002439	phosphorylation site [posttranslational modification]
868597002440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597002441	ATP binding site [chemical binding]; other site
868597002442	Mg2+ binding site [ion binding]; other site
868597002443	G-X-G motif; other site
868597002444	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
868597002445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597002446	active site
868597002447	phosphorylation site [posttranslational modification]
868597002448	intermolecular recognition site; other site
868597002449	dimerization interface [polypeptide binding]; other site
868597002450	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597002451	DNA binding site [nucleotide binding]
868597002452	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
868597002453	Peptidase family M48; Region: Peptidase_M48; pfam01435
868597002454	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
868597002455	GSH binding site [chemical binding]; other site
868597002456	catalytic residues [active]
868597002457	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
868597002458	isocitrate dehydrogenase; Provisional; Region: PRK08997
868597002459	tartrate dehydrogenase; Region: TTC; TIGR02089
868597002460	Isochorismatase family; Region: Isochorismatase; pfam00857
868597002461	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
868597002462	catalytic triad [active]
868597002463	conserved cis-peptide bond; other site
868597002464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597002465	LysR family transcriptional regulator; Provisional; Region: PRK14997
868597002466	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597002467	putative effector binding pocket; other site
868597002468	dimerization interface [polypeptide binding]; other site
868597002469	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
868597002470	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
868597002471	Bax inhibitor 1 like; Region: BaxI_1; cl17691
868597002472	trigger factor; Provisional; Region: tig; PRK01490
868597002473	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
868597002474	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
868597002475	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
868597002476	oligomer interface [polypeptide binding]; other site
868597002477	active site residues [active]
868597002478	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
868597002479	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
868597002480	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597002481	Walker A motif; other site
868597002482	ATP binding site [chemical binding]; other site
868597002483	Walker B motif; other site
868597002484	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
868597002485	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
868597002486	Found in ATP-dependent protease La (LON); Region: LON; smart00464
868597002487	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597002488	Walker A motif; other site
868597002489	ATP binding site [chemical binding]; other site
868597002490	Walker B motif; other site
868597002491	arginine finger; other site
868597002492	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
868597002493	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
868597002494	IHF dimer interface [polypeptide binding]; other site
868597002495	IHF - DNA interface [nucleotide binding]; other site
868597002496	periplasmic folding chaperone; Provisional; Region: PRK10788
868597002497	SurA N-terminal domain; Region: SurA_N_3; cl07813
868597002498	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
868597002499	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
868597002500	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597002501	catalytic residue [active]
868597002502	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
868597002503	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
868597002504	Methyltransferase domain; Region: Methyltransf_11; pfam08241
868597002505	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
868597002506	RNA/DNA hybrid binding site [nucleotide binding]; other site
868597002507	active site
868597002508	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
868597002509	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
868597002510	active site
868597002511	catalytic site [active]
868597002512	substrate binding site [chemical binding]; other site
868597002513	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
868597002514	Protein phosphatase 2C; Region: PP2C; pfam00481
868597002515	active site
868597002516	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
868597002517	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
868597002518	dimer interface [polypeptide binding]; other site
868597002519	active site
868597002520	Predicted transcriptional regulators [Transcription]; Region: COG1733
868597002521	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
868597002522	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
868597002523	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
868597002524	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
868597002525	putative active site [active]
868597002526	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
868597002527	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
868597002528	active site
868597002529	ATP binding site [chemical binding]; other site
868597002530	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
868597002531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
868597002532	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
868597002533	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
868597002534	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
868597002535	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
868597002536	Autotransporter beta-domain; Region: Autotransporter; pfam03797
868597002537	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
868597002538	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
868597002539	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597002540	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
868597002541	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597002542	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
868597002543	phosphopeptide binding site; other site
868597002544	Type II/IV secretion system protein; Region: T2SE; pfam00437
868597002545	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
868597002546	ATP binding site [chemical binding]; other site
868597002547	Walker A motif; other site
868597002548	hexamer interface [polypeptide binding]; other site
868597002549	Walker B motif; other site
868597002550	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
868597002551	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
868597002552	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
868597002553	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
868597002554	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
868597002555	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
868597002556	ligand binding site [chemical binding]; other site
868597002557	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
868597002558	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597002559	Walker A motif; other site
868597002560	ATP binding site [chemical binding]; other site
868597002561	Walker B motif; other site
868597002562	arginine finger; other site
868597002563	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
868597002564	hypothetical protein; Validated; Region: PRK00153
868597002565	recombination protein RecR; Reviewed; Region: recR; PRK00076
868597002566	RecR protein; Region: RecR; pfam02132
868597002567	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
868597002568	putative active site [active]
868597002569	putative metal-binding site [ion binding]; other site
868597002570	tetramer interface [polypeptide binding]; other site
868597002571	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
868597002572	nucleotide binding site/active site [active]
868597002573	HIT family signature motif; other site
868597002574	catalytic residue [active]
868597002575	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
868597002576	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
868597002577	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
868597002578	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
868597002579	Protein of unknown function DUF58; Region: DUF58; pfam01882
868597002580	MoxR-like ATPases [General function prediction only]; Region: COG0714
868597002581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597002582	Walker A motif; other site
868597002583	ATP binding site [chemical binding]; other site
868597002584	Walker B motif; other site
868597002585	arginine finger; other site
868597002586	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
868597002587	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
868597002588	Maf-like protein; Region: Maf; pfam02545
868597002589	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
868597002590	active site
868597002591	dimer interface [polypeptide binding]; other site
868597002592	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
868597002593	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
868597002594	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
868597002595	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
868597002596	dimer interface [polypeptide binding]; other site
868597002597	active site
868597002598	CoA binding pocket [chemical binding]; other site
868597002599	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
868597002600	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
868597002601	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
868597002602	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597002603	NAD(P) binding site [chemical binding]; other site
868597002604	active site
868597002605	acyl carrier protein; Provisional; Region: acpP; PRK00982
868597002606	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
868597002607	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
868597002608	dimer interface [polypeptide binding]; other site
868597002609	active site
868597002610	hypothetical protein; Validated; Region: PRK09070
868597002611	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
868597002612	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
868597002613	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
868597002614	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
868597002615	dimerization interface [polypeptide binding]; other site
868597002616	thymidylate kinase; Validated; Region: tmk; PRK00698
868597002617	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
868597002618	TMP-binding site; other site
868597002619	ATP-binding site [chemical binding]; other site
868597002620	DNA polymerase III subunit delta'; Validated; Region: PRK08769
868597002621	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
868597002622	active site
868597002623	nucleotide-binding site [chemical binding]; other site
868597002624	DNA polymerase III subunit delta'; Validated; Region: PRK08485
868597002625	PilZ domain; Region: PilZ; cl01260
868597002626	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
868597002627	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
868597002628	dimer interface [polypeptide binding]; other site
868597002629	hexamer interface [polypeptide binding]; other site
868597002630	active site 2 [active]
868597002631	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
868597002632	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597002633	N-terminal plug; other site
868597002634	ligand-binding site [chemical binding]; other site
868597002635	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
868597002636	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
868597002637	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
868597002638	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
868597002639	putative sugar binding sites [chemical binding]; other site
868597002640	Q-X-W motif; other site
868597002641	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
868597002642	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
868597002643	putative sugar binding sites [chemical binding]; other site
868597002644	Q-X-W motif; other site
868597002645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597002646	putative substrate translocation pore; other site
868597002647	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
868597002648	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
868597002649	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
868597002650	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
868597002651	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
868597002652	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
868597002653	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
868597002654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
868597002655	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
868597002656	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
868597002657	DNA-binding site [nucleotide binding]; DNA binding site
868597002658	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597002659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597002660	homodimer interface [polypeptide binding]; other site
868597002661	catalytic residue [active]
868597002662	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
868597002663	classical (c) SDRs; Region: SDR_c; cd05233
868597002664	NAD(P) binding site [chemical binding]; other site
868597002665	active site
868597002666	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
868597002667	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597002668	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
868597002669	dimerization interface [polypeptide binding]; other site
868597002670	substrate binding pocket [chemical binding]; other site
868597002671	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597002672	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597002673	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
868597002674	putative effector binding pocket; other site
868597002675	putative dimerization interface [polypeptide binding]; other site
868597002676	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
868597002677	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
868597002678	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597002679	N-terminal plug; other site
868597002680	ligand-binding site [chemical binding]; other site
868597002681	Uncharacterized conserved protein [Function unknown]; Region: COG3791
868597002682	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
868597002683	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
868597002684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597002685	Major Facilitator Superfamily; Region: MFS_1; pfam07690
868597002686	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
868597002687	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
868597002688	DNA binding residues [nucleotide binding]
868597002689	dimer interface [polypeptide binding]; other site
868597002690	[2Fe-2S] cluster binding site [ion binding]; other site
868597002691	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
868597002692	putative NAD(P) binding site [chemical binding]; other site
868597002693	homodimer interface [polypeptide binding]; other site
868597002694	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597002695	LysR family transcriptional regulator; Provisional; Region: PRK14997
868597002696	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
868597002697	putative effector binding pocket; other site
868597002698	putative dimerization interface [polypeptide binding]; other site
868597002699	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
868597002700	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
868597002701	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
868597002702	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
868597002703	catalytic residue [active]
868597002704	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
868597002705	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
868597002706	Walker A motif; other site
868597002707	ATP binding site [chemical binding]; other site
868597002708	Walker B motif; other site
868597002709	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
868597002710	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
868597002711	Walker A motif; other site
868597002712	ATP binding site [chemical binding]; other site
868597002713	Walker B motif; other site
868597002714	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
868597002715	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
868597002716	active site
868597002717	catalytic tetrad [active]
868597002718	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597002719	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597002720	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
868597002721	putative effector binding pocket; other site
868597002722	putative dimerization interface [polypeptide binding]; other site
868597002723	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
868597002724	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
868597002725	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597002726	Coenzyme A binding pocket [chemical binding]; other site
868597002727	Uncharacterized conserved protein [Function unknown]; Region: COG1284
868597002728	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
868597002729	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
868597002730	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
868597002731	hypothetical protein; Validated; Region: PRK00228
868597002732	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
868597002733	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
868597002734	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
868597002735	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
868597002736	Transposase IS200 like; Region: Y1_Tnp; pfam01797
868597002737	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
868597002738	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
868597002739	MgtE intracellular N domain; Region: MgtE_N; smart00924
868597002740	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
868597002741	Divalent cation transporter; Region: MgtE; pfam01769
868597002742	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
868597002743	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
868597002744	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
868597002745	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
868597002746	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
868597002747	dimerization domain swap beta strand [polypeptide binding]; other site
868597002748	regulatory protein interface [polypeptide binding]; other site
868597002749	active site
868597002750	regulatory phosphorylation site [posttranslational modification]; other site
868597002751	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
868597002752	active pocket/dimerization site; other site
868597002753	active site
868597002754	phosphorylation site [posttranslational modification]
868597002755	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
868597002756	AAA domain; Region: AAA_33; pfam13671
868597002757	HPr kinase/phosphorylase; Provisional; Region: PRK05428
868597002758	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
868597002759	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
868597002760	Hpr binding site; other site
868597002761	active site
868597002762	homohexamer subunit interaction site [polypeptide binding]; other site
868597002763	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
868597002764	active site
868597002765	phosphorylation site [posttranslational modification]
868597002766	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
868597002767	30S subunit binding site; other site
868597002768	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
868597002769	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
868597002770	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
868597002771	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
868597002772	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
868597002773	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
868597002774	Walker A/P-loop; other site
868597002775	ATP binding site [chemical binding]; other site
868597002776	Q-loop/lid; other site
868597002777	ABC transporter signature motif; other site
868597002778	Walker B; other site
868597002779	D-loop; other site
868597002780	H-loop/switch region; other site
868597002781	OstA-like protein; Region: OstA; cl00844
868597002782	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
868597002783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
868597002784	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
868597002785	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
868597002786	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
868597002787	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
868597002788	putative active site [active]
868597002789	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
868597002790	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
868597002791	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
868597002792	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
868597002793	hinge; other site
868597002794	active site
868597002795	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
868597002796	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
868597002797	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
868597002798	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
868597002799	active site
868597002800	substrate binding site [chemical binding]; other site
868597002801	cosubstrate binding site; other site
868597002802	catalytic site [active]
868597002803	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
868597002804	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
868597002805	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
868597002806	dimerization interface [polypeptide binding]; other site
868597002807	putative ATP binding site [chemical binding]; other site
868597002808	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
868597002809	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
868597002810	Domain of unknown function DUF20; Region: UPF0118; pfam01594
868597002811	hypothetical protein; Validated; Region: PRK08727
868597002812	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
868597002813	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
868597002814	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
868597002815	Substrate binding site; other site
868597002816	metal-binding site
868597002817	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
868597002818	Phosphotransferase enzyme family; Region: APH; pfam01636
868597002819	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
868597002820	hypothetical protein; Provisional; Region: PRK08201
868597002821	metal binding site [ion binding]; metal-binding site
868597002822	putative dimer interface [polypeptide binding]; other site
868597002823	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
868597002824	hypothetical protein; Provisional; Region: PRK06132
868597002825	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
868597002826	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
868597002827	HutD; Region: HutD; pfam05962
868597002828	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
868597002829	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
868597002830	FAD binding pocket [chemical binding]; other site
868597002831	FAD binding motif [chemical binding]; other site
868597002832	catalytic residues [active]
868597002833	NAD binding pocket [chemical binding]; other site
868597002834	phosphate binding motif [ion binding]; other site
868597002835	beta-alpha-beta structure motif; other site
868597002836	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
868597002837	ApbE family; Region: ApbE; pfam02424
868597002838	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
868597002839	Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856
868597002840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
868597002841	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
868597002842	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
868597002843	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597002844	N-terminal plug; other site
868597002845	ligand-binding site [chemical binding]; other site
868597002846	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
868597002847	Sel1 repeat; Region: Sel1; cl02723
868597002848	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
868597002849	Sel1 repeat; Region: Sel1; cl02723
868597002850	Sel1-like repeats; Region: SEL1; smart00671
868597002851	Sel1-like repeats; Region: SEL1; smart00671
868597002852	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
868597002853	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597002854	N-terminal plug; other site
868597002855	ligand-binding site [chemical binding]; other site
868597002856	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
868597002857	[2Fe-2S] cluster binding site [ion binding]; other site
868597002858	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
868597002859	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597002860	Coenzyme A binding pocket [chemical binding]; other site
868597002861	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
868597002862	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
868597002863	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
868597002864	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597002865	catalytic residue [active]
868597002866	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
868597002867	FeS assembly protein SufD; Region: sufD; TIGR01981
868597002868	FeS assembly ATPase SufC; Region: sufC; TIGR01978
868597002869	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
868597002870	Walker A/P-loop; other site
868597002871	ATP binding site [chemical binding]; other site
868597002872	Q-loop/lid; other site
868597002873	ABC transporter signature motif; other site
868597002874	Walker B; other site
868597002875	D-loop; other site
868597002876	H-loop/switch region; other site
868597002877	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
868597002878	putative ABC transporter; Region: ycf24; CHL00085
868597002879	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
868597002880	Transcriptional regulator; Region: Rrf2; pfam02082
868597002881	Transcriptional regulator; Region: Rrf2; cl17282
868597002882	Proteins containing SET domain [General function prediction only]; Region: COG2940
868597002883	SET domain; Region: SET; pfam00856
868597002884	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
868597002885	intracellular protease, PfpI family; Region: PfpI; TIGR01382
868597002886	proposed catalytic triad [active]
868597002887	conserved cys residue [active]
868597002888	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
868597002889	IHF dimer interface [polypeptide binding]; other site
868597002890	IHF - DNA interface [nucleotide binding]; other site
868597002891	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
868597002892	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
868597002893	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
868597002894	bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961
868597002895	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
868597002896	nucleotide binding site [chemical binding]; other site
868597002897	substrate binding site [chemical binding]; other site
868597002898	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935
868597002899	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
868597002900	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
868597002901	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
868597002902	catalytic residue [active]
868597002903	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690
868597002904	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
868597002905	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
868597002906	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
868597002907	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
868597002908	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
868597002909	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
868597002910	substrate binding pocket [chemical binding]; other site
868597002911	chain length determination region; other site
868597002912	substrate-Mg2+ binding site; other site
868597002913	catalytic residues [active]
868597002914	aspartate-rich region 1; other site
868597002915	active site lid residues [active]
868597002916	aspartate-rich region 2; other site
868597002917	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
868597002918	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
868597002919	active site
868597002920	catalytic site [active]
868597002921	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
868597002922	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
868597002923	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597002924	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597002925	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
868597002926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597002927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597002928	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
868597002929	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
868597002930	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
868597002931	active site
868597002932	catalytic site [active]
868597002933	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
868597002934	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
868597002935	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
868597002936	Zn binding site [ion binding]; other site
868597002937	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
868597002938	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
868597002939	Walker A/P-loop; other site
868597002940	ATP binding site [chemical binding]; other site
868597002941	Q-loop/lid; other site
868597002942	ABC transporter signature motif; other site
868597002943	Walker B; other site
868597002944	D-loop; other site
868597002945	H-loop/switch region; other site
868597002946	Transcriptional regulators [Transcription]; Region: PurR; COG1609
868597002947	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
868597002948	DNA binding site [nucleotide binding]
868597002949	domain linker motif; other site
868597002950	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
868597002951	putative dimerization interface [polypeptide binding]; other site
868597002952	putative ligand binding site [chemical binding]; other site
868597002953	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
868597002954	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
868597002955	dimer interface [polypeptide binding]; other site
868597002956	ssDNA binding site [nucleotide binding]; other site
868597002957	tetramer (dimer of dimers) interface [polypeptide binding]; other site
868597002958	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
868597002959	RHS Repeat; Region: RHS_repeat; pfam05593
868597002960	RHS Repeat; Region: RHS_repeat; cl11982
868597002961	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
868597002962	RHS Repeat; Region: RHS_repeat; pfam05593
868597002963	RHS Repeat; Region: RHS_repeat; pfam05593
868597002964	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
868597002965	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597002966	TPR motif; other site
868597002967	Tetratricopeptide repeat; Region: TPR_16; pfam13432
868597002968	binding surface
868597002969	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
868597002970	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
868597002971	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
868597002972	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
868597002973	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
868597002974	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
868597002975	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
868597002976	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
868597002977	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
868597002978	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
868597002979	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
868597002980	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
868597002981	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
868597002982	Metal-binding active site; metal-binding site
868597002983	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
868597002984	Transcriptional regulators [Transcription]; Region: PurR; COG1609
868597002985	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
868597002986	DNA binding site [nucleotide binding]
868597002987	domain linker motif; other site
868597002988	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
868597002989	dimerization interface [polypeptide binding]; other site
868597002990	ligand binding site [chemical binding]; other site
868597002991	MASE2 domain; Region: MASE2; pfam05230
868597002992	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597002993	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597002994	metal binding site [ion binding]; metal-binding site
868597002995	active site
868597002996	I-site; other site
868597002997	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
868597002998	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597002999	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597003000	metal binding site [ion binding]; metal-binding site
868597003001	active site
868597003002	I-site; other site
868597003003	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
868597003004	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597003005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597003006	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
868597003007	putative effector binding pocket; other site
868597003008	putative dimerization interface [polypeptide binding]; other site
868597003009	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
868597003010	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
868597003011	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597003012	dimerization interface [polypeptide binding]; other site
868597003013	putative DNA binding site [nucleotide binding]; other site
868597003014	putative Zn2+ binding site [ion binding]; other site
868597003015	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
868597003016	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597003017	non-specific DNA binding site [nucleotide binding]; other site
868597003018	salt bridge; other site
868597003019	sequence-specific DNA binding site [nucleotide binding]; other site
868597003020	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
868597003021	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
868597003022	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
868597003023	Transporter associated domain; Region: CorC_HlyC; pfam03471
868597003024	phosphodiesterase YaeI; Provisional; Region: PRK11340
868597003025	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
868597003026	putative active site [active]
868597003027	putative metal binding site [ion binding]; other site
868597003028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597003029	metabolite-proton symporter; Region: 2A0106; TIGR00883
868597003030	putative substrate translocation pore; other site
868597003031	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
868597003032	active site
868597003033	Transcriptional regulators [Transcription]; Region: GntR; COG1802
868597003034	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
868597003035	DNA-binding site [nucleotide binding]; DNA binding site
868597003036	FCD domain; Region: FCD; pfam07729
868597003037	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
868597003038	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
868597003039	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
868597003040	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
868597003041	triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132
868597003042	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098
868597003043	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
868597003044	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
868597003045	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
868597003046	malonate decarboxylase subunit delta; Provisional; Region: PRK02103
868597003047	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
868597003048	Coenzyme A transferase; Region: CoA_trans; cl17247
868597003049	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
868597003050	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597003051	N-terminal plug; other site
868597003052	ligand-binding site [chemical binding]; other site
868597003053	malate:quinone oxidoreductase; Validated; Region: PRK05257
868597003054	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
868597003055	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
868597003056	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597003057	Coenzyme A binding pocket [chemical binding]; other site
868597003058	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
868597003059	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597003060	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597003061	dimerization interface [polypeptide binding]; other site
868597003062	LysE type translocator; Region: LysE; cl00565
868597003063	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
868597003064	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597003065	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
868597003066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597003067	POT family; Region: PTR2; cl17359
868597003068	Predicted membrane protein [Function unknown]; Region: COG3503
868597003069	Predicted membrane protein [Function unknown]; Region: COG1297
868597003070	putative oligopeptide transporter, OPT family; Region: TIGR00733
868597003071	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
868597003072	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597003073	Protein of unknown function (DUF819); Region: DUF819; pfam05684
868597003074	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
868597003075	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
868597003076	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
868597003077	Switch I; other site
868597003078	Switch II; other site
868597003079	septum formation inhibitor; Reviewed; Region: minC; PRK04596
868597003080	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
868597003081	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
868597003082	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597003083	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
868597003084	Histidine kinase; Region: HisKA_3; pfam07730
868597003085	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597003086	ATP binding site [chemical binding]; other site
868597003087	Mg2+ binding site [ion binding]; other site
868597003088	G-X-G motif; other site
868597003089	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597003090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597003091	active site
868597003092	phosphorylation site [posttranslational modification]
868597003093	intermolecular recognition site; other site
868597003094	dimerization interface [polypeptide binding]; other site
868597003095	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597003096	DNA binding residues [nucleotide binding]
868597003097	dimerization interface [polypeptide binding]; other site
868597003098	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
868597003099	putative hydrophobic ligand binding site [chemical binding]; other site
868597003100	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
868597003101	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
868597003102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
868597003103	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
868597003104	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
868597003105	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
868597003106	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597003107	ATP-grasp domain; Region: ATP-grasp; pfam02222
868597003108	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
868597003109	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
868597003110	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
868597003111	EF-hand domain pair; Region: EF_hand_5; pfam13499
868597003112	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
868597003113	EF-hand domain pair; Region: EF_hand_5; pfam13499
868597003114	Ca2+ binding site [ion binding]; other site
868597003115	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
868597003116	EF-hand domain pair; Region: EF_hand_5; pfam13499
868597003117	Ca2+ binding site [ion binding]; other site
868597003118	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
868597003119	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597003120	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597003121	DNA binding residues [nucleotide binding]
868597003122	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
868597003123	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
868597003124	active site
868597003125	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
868597003126	catalytic triad [active]
868597003127	dimer interface [polypeptide binding]; other site
868597003128	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
868597003129	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
868597003130	substrate binding site [chemical binding]; other site
868597003131	oxyanion hole (OAH) forming residues; other site
868597003132	trimer interface [polypeptide binding]; other site
868597003133	Protein of unknown function (DUF461); Region: DUF461; pfam04314
868597003134	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
868597003135	active site
868597003136	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
868597003137	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
868597003138	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
868597003139	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
868597003140	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
868597003141	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
868597003142	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
868597003143	GTPase CgtA; Reviewed; Region: obgE; PRK12299
868597003144	GTP1/OBG; Region: GTP1_OBG; pfam01018
868597003145	Obg GTPase; Region: Obg; cd01898
868597003146	G1 box; other site
868597003147	GTP/Mg2+ binding site [chemical binding]; other site
868597003148	Switch I region; other site
868597003149	G2 box; other site
868597003150	G3 box; other site
868597003151	Switch II region; other site
868597003152	G4 box; other site
868597003153	G5 box; other site
868597003154	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
868597003155	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
868597003156	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
868597003157	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
868597003158	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
868597003159	active site
868597003160	Riboflavin kinase; Region: Flavokinase; pfam01687
868597003161	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
868597003162	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
868597003163	active site
868597003164	HIGH motif; other site
868597003165	nucleotide binding site [chemical binding]; other site
868597003166	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
868597003167	active site
868597003168	KMSKS motif; other site
868597003169	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
868597003170	tRNA binding surface [nucleotide binding]; other site
868597003171	anticodon binding site; other site
868597003172	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
868597003173	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
868597003174	lipoprotein signal peptidase; Provisional; Region: PRK14787
868597003175	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
868597003176	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
868597003177	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
868597003178	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
868597003179	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
868597003180	protein binding site [polypeptide binding]; other site
868597003181	YhhN-like protein; Region: YhhN; pfam07947
868597003182	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597003183	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597003184	N-terminal plug; other site
868597003185	ligand-binding site [chemical binding]; other site
868597003186	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
868597003187	FecR protein; Region: FecR; pfam04773
868597003188	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
868597003189	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597003190	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597003191	DNA binding residues [nucleotide binding]
868597003192	Autotransporter beta-domain; Region: Autotransporter; smart00869
868597003193	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
868597003194	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
868597003195	putative ligand binding site [chemical binding]; other site
868597003196	putative NAD binding site [chemical binding]; other site
868597003197	catalytic site [active]
868597003198	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
868597003199	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
868597003200	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
868597003201	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
868597003202	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
868597003203	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
868597003204	D-pathway; other site
868597003205	Putative ubiquinol binding site [chemical binding]; other site
868597003206	Low-spin heme (heme b) binding site [chemical binding]; other site
868597003207	Putative water exit pathway; other site
868597003208	Binuclear center (heme o3/CuB) [ion binding]; other site
868597003209	K-pathway; other site
868597003210	Putative proton exit pathway; other site
868597003211	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
868597003212	Subunit I/III interface [polypeptide binding]; other site
868597003213	Subunit III/IV interface [polypeptide binding]; other site
868597003214	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
868597003215	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
868597003216	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
868597003217	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
868597003218	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597003219	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597003220	metal binding site [ion binding]; metal-binding site
868597003221	active site
868597003222	I-site; other site
868597003223	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597003224	DNA repair protein RadA; Provisional; Region: PRK11823
868597003225	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
868597003226	Walker A motif/ATP binding site; other site
868597003227	ATP binding site [chemical binding]; other site
868597003228	Walker B motif; other site
868597003229	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
868597003230	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
868597003231	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
868597003232	ATP binding site [chemical binding]; other site
868597003233	Mg2+ binding site [ion binding]; other site
868597003234	G-X-G motif; other site
868597003235	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
868597003236	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
868597003237	signal recognition particle protein; Provisional; Region: PRK10867
868597003238	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
868597003239	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
868597003240	P loop; other site
868597003241	GTP binding site [chemical binding]; other site
868597003242	Signal peptide binding domain; Region: SRP_SPB; pfam02978
868597003243	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
868597003244	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
868597003245	FMN binding site [chemical binding]; other site
868597003246	substrate binding site [chemical binding]; other site
868597003247	putative catalytic residue [active]
868597003248	hypothetical protein; Provisional; Region: PRK09266
868597003249	homodimer interface [polypeptide binding]; other site
868597003250	substrate-cofactor binding pocket; other site
868597003251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597003252	catalytic residue [active]
868597003253	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
868597003254	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
868597003255	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
868597003256	RimM N-terminal domain; Region: RimM; pfam01782
868597003257	PRC-barrel domain; Region: PRC; pfam05239
868597003258	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
868597003259	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
868597003260	Uncharacterized conserved protein [Function unknown]; Region: COG5649
868597003261	Uncharacterized conserved protein [Function unknown]; Region: COG5649
868597003262	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
868597003263	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
868597003264	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597003265	RNA binding surface [nucleotide binding]; other site
868597003266	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
868597003267	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
868597003268	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
868597003269	tetramer interface [polypeptide binding]; other site
868597003270	heme binding pocket [chemical binding]; other site
868597003271	NADPH binding site [chemical binding]; other site
868597003272	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
868597003273	MutS domain I; Region: MutS_I; pfam01624
868597003274	MutS domain II; Region: MutS_II; pfam05188
868597003275	MutS domain III; Region: MutS_III; pfam05192
868597003276	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
868597003277	Walker A/P-loop; other site
868597003278	ATP binding site [chemical binding]; other site
868597003279	Q-loop/lid; other site
868597003280	ABC transporter signature motif; other site
868597003281	Walker B; other site
868597003282	D-loop; other site
868597003283	H-loop/switch region; other site
868597003284	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
868597003285	RNAase interaction site [polypeptide binding]; other site
868597003286	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
868597003287	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
868597003288	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
868597003289	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
868597003290	haemagglutination activity domain; Region: Haemagg_act; pfam05860
868597003291	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
868597003292	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
868597003293	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
868597003294	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
868597003295	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
868597003296	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
868597003297	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
868597003298	dimerization interface [polypeptide binding]; other site
868597003299	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
868597003300	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597003301	dimer interface [polypeptide binding]; other site
868597003302	putative CheW interface [polypeptide binding]; other site
868597003303	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
868597003304	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
868597003305	ABC-2 type transporter; Region: ABC2_membrane; cl17235
868597003306	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
868597003307	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
868597003308	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597003309	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597003310	Outer membrane efflux protein; Region: OEP; pfam02321
868597003311	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
868597003312	Switch II region; other site
868597003313	G3 box; other site
868597003314	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
868597003315	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597003316	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597003317	dimerization interface [polypeptide binding]; other site
868597003318	Lysine efflux permease [General function prediction only]; Region: COG1279
868597003319	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
868597003320	active site
868597003321	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
868597003322	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
868597003323	dimer interface [polypeptide binding]; other site
868597003324	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597003325	ligand binding site [chemical binding]; other site
868597003326	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
868597003327	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
868597003328	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
868597003329	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
868597003330	inhibitor-cofactor binding pocket; inhibition site
868597003331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597003332	catalytic residue [active]
868597003333	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
868597003334	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
868597003335	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
868597003336	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597003337	catalytic residue [active]
868597003338	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
868597003339	EamA-like transporter family; Region: EamA; pfam00892
868597003340	Esterase/lipase [General function prediction only]; Region: COG1647
868597003341	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
868597003342	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597003343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597003344	dimer interface [polypeptide binding]; other site
868597003345	phosphorylation site [posttranslational modification]
868597003346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597003347	ATP binding site [chemical binding]; other site
868597003348	Mg2+ binding site [ion binding]; other site
868597003349	G-X-G motif; other site
868597003350	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
868597003351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597003352	active site
868597003353	phosphorylation site [posttranslational modification]
868597003354	intermolecular recognition site; other site
868597003355	dimerization interface [polypeptide binding]; other site
868597003356	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597003357	DNA binding site [nucleotide binding]
868597003358	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
868597003359	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
868597003360	active site
868597003361	metal binding site [ion binding]; metal-binding site
868597003362	Predicted transcriptional regulators [Transcription]; Region: COG1733
868597003363	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
868597003364	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
868597003365	heme-binding site [chemical binding]; other site
868597003366	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597003367	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597003368	metal binding site [ion binding]; metal-binding site
868597003369	active site
868597003370	I-site; other site
868597003371	outer membrane receptor FepA; Provisional; Region: PRK13524
868597003372	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597003373	N-terminal plug; other site
868597003374	ligand-binding site [chemical binding]; other site
868597003375	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
868597003376	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
868597003377	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
868597003378	Active_site [active]
868597003379	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
868597003380	catalytic core [active]
868597003381	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
868597003382	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
868597003383	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
868597003384	active site
868597003385	Zn binding site [ion binding]; other site
868597003386	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
868597003387	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
868597003388	Zn2+ binding site [ion binding]; other site
868597003389	Mg2+ binding site [ion binding]; other site
868597003390	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
868597003391	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
868597003392	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
868597003393	ATP binding site [chemical binding]; other site
868597003394	putative Mg++ binding site [ion binding]; other site
868597003395	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597003396	nucleotide binding region [chemical binding]; other site
868597003397	ATP-binding site [chemical binding]; other site
868597003398	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
868597003399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
868597003400	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
868597003401	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
868597003402	DNA-binding response regulator CreB; Provisional; Region: PRK11083
868597003403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597003404	active site
868597003405	phosphorylation site [posttranslational modification]
868597003406	intermolecular recognition site; other site
868597003407	dimerization interface [polypeptide binding]; other site
868597003408	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597003409	DNA binding site [nucleotide binding]
868597003410	sensory histidine kinase CreC; Provisional; Region: PRK11100
868597003411	HAMP domain; Region: HAMP; pfam00672
868597003412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597003413	dimer interface [polypeptide binding]; other site
868597003414	phosphorylation site [posttranslational modification]
868597003415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597003416	ATP binding site [chemical binding]; other site
868597003417	Mg2+ binding site [ion binding]; other site
868597003418	G-X-G motif; other site
868597003419	inner membrane protein; Provisional; Region: PRK11715
868597003420	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
868597003421	M28 Zn-Peptidases; Region: M28_like_4; cd08015
868597003422	Peptidase family M28; Region: Peptidase_M28; pfam04389
868597003423	metal binding site [ion binding]; metal-binding site
868597003424	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
868597003425	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
868597003426	active site
868597003427	HIGH motif; other site
868597003428	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
868597003429	active site
868597003430	KMSKS motif; other site
868597003431	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
868597003432	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
868597003433	metal binding site 2 [ion binding]; metal-binding site
868597003434	putative DNA binding helix; other site
868597003435	metal binding site 1 [ion binding]; metal-binding site
868597003436	dimer interface [polypeptide binding]; other site
868597003437	structural Zn2+ binding site [ion binding]; other site
868597003438	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
868597003439	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597003440	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597003441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597003442	putative substrate translocation pore; other site
868597003443	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
868597003444	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597003445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597003446	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597003447	N-terminal plug; other site
868597003448	ligand-binding site [chemical binding]; other site
868597003449	MerC mercury resistance protein; Region: MerC; pfam03203
868597003450	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
868597003451	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
868597003452	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
868597003453	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
868597003454	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
868597003455	DNA binding site [nucleotide binding]
868597003456	active site
868597003457	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
868597003458	Helix-turn-helix domain; Region: HTH_18; pfam12833
868597003459	AlkA N-terminal domain; Region: AlkA_N; pfam06029
868597003460	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
868597003461	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
868597003462	helix-hairpin-helix signature motif; other site
868597003463	substrate binding pocket [chemical binding]; other site
868597003464	active site
868597003465	Predicted periplasmic protein [Function unknown]; Region: COG3904
868597003466	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
868597003467	MAPEG family; Region: MAPEG; cl09190
868597003468	hypothetical protein; Provisional; Region: PRK09126
868597003469	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
868597003470	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597003471	RNA binding surface [nucleotide binding]; other site
868597003472	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
868597003473	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
868597003474	ATP binding site [chemical binding]; other site
868597003475	Mg++ binding site [ion binding]; other site
868597003476	motif III; other site
868597003477	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597003478	nucleotide binding region [chemical binding]; other site
868597003479	ATP-binding site [chemical binding]; other site
868597003480	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
868597003481	putative RNA binding site [nucleotide binding]; other site
868597003482	PAS domain S-box; Region: sensory_box; TIGR00229
868597003483	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597003484	putative active site [active]
868597003485	heme pocket [chemical binding]; other site
868597003486	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597003487	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597003488	metal binding site [ion binding]; metal-binding site
868597003489	active site
868597003490	I-site; other site
868597003491	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597003492	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597003493	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597003494	metal binding site [ion binding]; metal-binding site
868597003495	active site
868597003496	I-site; other site
868597003497	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
868597003498	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597003499	RNA binding surface [nucleotide binding]; other site
868597003500	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
868597003501	probable active site [active]
868597003502	GAF domain; Region: GAF; pfam01590
868597003503	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
868597003504	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597003505	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597003506	metal binding site [ion binding]; metal-binding site
868597003507	active site
868597003508	I-site; other site
868597003509	Predicted ATPase [General function prediction only]; Region: COG4637
868597003510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597003511	Walker A/P-loop; other site
868597003512	ATP binding site [chemical binding]; other site
868597003513	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597003514	ABC transporter signature motif; other site
868597003515	Walker B; other site
868597003516	D-loop; other site
868597003517	H-loop/switch region; other site
868597003518	EamA-like transporter family; Region: EamA; pfam00892
868597003519	Protein of unknown function DUF72; Region: DUF72; pfam01904
868597003520	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
868597003521	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597003522	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
868597003523	Beta-lactamase; Region: Beta-lactamase; pfam00144
868597003524	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
868597003525	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
868597003526	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
868597003527	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597003528	Walker A/P-loop; other site
868597003529	ATP binding site [chemical binding]; other site
868597003530	Q-loop/lid; other site
868597003531	ABC transporter signature motif; other site
868597003532	Walker B; other site
868597003533	D-loop; other site
868597003534	H-loop/switch region; other site
868597003535	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
868597003536	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
868597003537	catalytic core [active]
868597003538	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
868597003539	poly(beta-D-mannuronate) lyase; Provisional; Region: algL; PRK00325
868597003540	active site
868597003541	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
868597003542	Uncharacterized conserved protein [Function unknown]; Region: COG3791
868597003543	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
868597003544	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
868597003545	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597003546	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
868597003547	dimerization interface [polypeptide binding]; other site
868597003548	substrate binding pocket [chemical binding]; other site
868597003549	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
868597003550	EamA-like transporter family; Region: EamA; pfam00892
868597003551	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
868597003552	active site
868597003553	Predicted transcriptional regulators [Transcription]; Region: COG1695
868597003554	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
868597003555	Predicted membrane protein [Function unknown]; Region: COG4709
868597003556	Putative sensor; Region: Sensor; pfam13796
868597003557	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
868597003558	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
868597003559	Methyltransferase domain; Region: Methyltransf_23; pfam13489
868597003560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597003561	S-adenosylmethionine binding site [chemical binding]; other site
868597003562	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
868597003563	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
868597003564	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
868597003565	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
868597003566	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
868597003567	putative active site [active]
868597003568	putative PHP Thumb interface [polypeptide binding]; other site
868597003569	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
868597003570	generic binding surface II; other site
868597003571	generic binding surface I; other site
868597003572	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
868597003573	RNA/DNA hybrid binding site [nucleotide binding]; other site
868597003574	active site
868597003575	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
868597003576	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
868597003577	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
868597003578	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
868597003579	active site
868597003580	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
868597003581	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
868597003582	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
868597003583	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
868597003584	trimer interface [polypeptide binding]; other site
868597003585	active site
868597003586	UDP-GlcNAc binding site [chemical binding]; other site
868597003587	lipid binding site [chemical binding]; lipid-binding site
868597003588	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
868597003589	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
868597003590	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
868597003591	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
868597003592	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
868597003593	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
868597003594	Surface antigen; Region: Bac_surface_Ag; pfam01103
868597003595	zinc metallopeptidase RseP; Provisional; Region: PRK10779
868597003596	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
868597003597	active site
868597003598	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
868597003599	protein binding site [polypeptide binding]; other site
868597003600	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
868597003601	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
868597003602	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
868597003603	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
868597003604	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
868597003605	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
868597003606	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
868597003607	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836
868597003608	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
868597003609	catalytic residue [active]
868597003610	putative FPP diphosphate  binding site; other site
868597003611	putative FPP binding hydrophobic cleft; other site
868597003612	dimer interface [polypeptide binding]; other site
868597003613	putative IPP diphosphate binding site; other site
868597003614	ribosome recycling factor; Reviewed; Region: frr; PRK00083
868597003615	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
868597003616	hinge region; other site
868597003617	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
868597003618	putative nucleotide binding site [chemical binding]; other site
868597003619	uridine monophosphate binding site [chemical binding]; other site
868597003620	homohexameric interface [polypeptide binding]; other site
868597003621	HDOD domain; Region: HDOD; pfam08668
868597003622	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597003623	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597003624	metal binding site [ion binding]; metal-binding site
868597003625	active site
868597003626	I-site; other site
868597003627	elongation factor Ts; Provisional; Region: tsf; PRK09377
868597003628	UBA/TS-N domain; Region: UBA; pfam00627
868597003629	Elongation factor TS; Region: EF_TS; pfam00889
868597003630	Elongation factor TS; Region: EF_TS; pfam00889
868597003631	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
868597003632	rRNA interaction site [nucleotide binding]; other site
868597003633	S8 interaction site; other site
868597003634	putative laminin-1 binding site; other site
868597003635	Spore Coat Protein U domain; Region: SCPU; cl02253
868597003636	Spore Coat Protein U domain; Region: SCPU; pfam05229
868597003637	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
868597003638	PapC N-terminal domain; Region: PapC_N; pfam13954
868597003639	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
868597003640	PapC C-terminal domain; Region: PapC_C; pfam13953
868597003641	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
868597003642	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
868597003643	Spore Coat Protein U domain; Region: SCPU; pfam05229
868597003644	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
868597003645	active site
868597003646	PII uridylyl-transferase; Provisional; Region: PRK04374
868597003647	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
868597003648	metal binding triad; other site
868597003649	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
868597003650	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
868597003651	Zn2+ binding site [ion binding]; other site
868597003652	Mg2+ binding site [ion binding]; other site
868597003653	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
868597003654	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
868597003655	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
868597003656	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
868597003657	trimer interface [polypeptide binding]; other site
868597003658	active site
868597003659	substrate binding site [chemical binding]; other site
868597003660	CoA binding site [chemical binding]; other site
868597003661	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
868597003662	ArsC family; Region: ArsC; pfam03960
868597003663	putative catalytic residues [active]
868597003664	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
868597003665	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
868597003666	metal binding site [ion binding]; metal-binding site
868597003667	dimer interface [polypeptide binding]; other site
868597003668	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
868597003669	Sel1-like repeats; Region: SEL1; smart00671
868597003670	asparagine synthetase B; Provisional; Region: asnB; PRK09431
868597003671	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
868597003672	active site
868597003673	dimer interface [polypeptide binding]; other site
868597003674	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
868597003675	Ligand Binding Site [chemical binding]; other site
868597003676	Molecular Tunnel; other site
868597003677	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
868597003678	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
868597003679	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
868597003680	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
868597003681	active site
868597003682	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
868597003683	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
868597003684	heme binding site [chemical binding]; other site
868597003685	ferroxidase pore; other site
868597003686	ferroxidase diiron center [ion binding]; other site
868597003687	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
868597003688	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
868597003689	CAP-like domain; other site
868597003690	active site
868597003691	primary dimer interface [polypeptide binding]; other site
868597003692	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
868597003693	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597003694	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
868597003695	MarR family; Region: MarR_2; pfam12802
868597003696	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
868597003697	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
868597003698	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597003699	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597003700	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
868597003701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597003702	putative substrate translocation pore; other site
868597003703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597003704	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597003705	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597003706	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
868597003707	putative dimerization interface [polypeptide binding]; other site
868597003708	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
868597003709	ribonuclease R; Region: RNase_R; TIGR02063
868597003710	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597003711	putative DNA binding site [nucleotide binding]; other site
868597003712	putative Zn2+ binding site [ion binding]; other site
868597003713	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
868597003714	RNB domain; Region: RNB; pfam00773
868597003715	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
868597003716	RNA binding site [nucleotide binding]; other site
868597003717	Uncharacterized conserved protein [Function unknown]; Region: COG3791
868597003718	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
868597003719	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
868597003720	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
868597003721	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
868597003722	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
868597003723	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
868597003724	Walker A/P-loop; other site
868597003725	ATP binding site [chemical binding]; other site
868597003726	Q-loop/lid; other site
868597003727	ABC transporter signature motif; other site
868597003728	Walker B; other site
868597003729	D-loop; other site
868597003730	H-loop/switch region; other site
868597003731	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597003732	FtsX-like permease family; Region: FtsX; pfam02687
868597003733	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597003734	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597003735	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597003736	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597003737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597003738	active site
868597003739	phosphorylation site [posttranslational modification]
868597003740	intermolecular recognition site; other site
868597003741	dimerization interface [polypeptide binding]; other site
868597003742	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597003743	DNA binding site [nucleotide binding]
868597003744	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
868597003745	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597003746	ATP binding site [chemical binding]; other site
868597003747	Mg2+ binding site [ion binding]; other site
868597003748	G-X-G motif; other site
868597003749	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
868597003750	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
868597003751	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597003752	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597003753	metal binding site [ion binding]; metal-binding site
868597003754	active site
868597003755	I-site; other site
868597003756	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
868597003757	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
868597003758	dimer interface [polypeptide binding]; other site
868597003759	catalytic site [active]
868597003760	putative active site [active]
868597003761	putative substrate binding site [chemical binding]; other site
868597003762	Predicted membrane protein [Function unknown]; Region: COG2259
868597003763	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
868597003764	hypothetical protein; Provisional; Region: PRK05409
868597003765	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
868597003766	PhoU domain; Region: PhoU; pfam01895
868597003767	PhoU domain; Region: PhoU; pfam01895
868597003768	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
868597003769	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
868597003770	Walker A/P-loop; other site
868597003771	ATP binding site [chemical binding]; other site
868597003772	Q-loop/lid; other site
868597003773	ABC transporter signature motif; other site
868597003774	Walker B; other site
868597003775	D-loop; other site
868597003776	H-loop/switch region; other site
868597003777	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
868597003778	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597003779	dimer interface [polypeptide binding]; other site
868597003780	conserved gate region; other site
868597003781	putative PBP binding loops; other site
868597003782	ABC-ATPase subunit interface; other site
868597003783	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
868597003784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597003785	dimer interface [polypeptide binding]; other site
868597003786	conserved gate region; other site
868597003787	putative PBP binding loops; other site
868597003788	ABC-ATPase subunit interface; other site
868597003789	PBP superfamily domain; Region: PBP_like_2; cl17296
868597003790	PBP superfamily domain; Region: PBP_like_2; cl17296
868597003791	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
868597003792	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
868597003793	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
868597003794	minor groove reading motif; other site
868597003795	helix-hairpin-helix signature motif; other site
868597003796	substrate binding pocket [chemical binding]; other site
868597003797	active site
868597003798	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
868597003799	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
868597003800	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
868597003801	substrate binding site [chemical binding]; other site
868597003802	oxyanion hole (OAH) forming residues; other site
868597003803	trimer interface [polypeptide binding]; other site
868597003804	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
868597003805	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
868597003806	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
868597003807	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
868597003808	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
868597003809	putative active site [active]
868597003810	putative CoA binding site [chemical binding]; other site
868597003811	nudix motif; other site
868597003812	metal binding site [ion binding]; metal-binding site
868597003813	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
868597003814	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
868597003815	active site residue [active]
868597003816	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
868597003817	active site residue [active]
868597003818	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
868597003819	substrate binding site [chemical binding]; other site
868597003820	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
868597003821	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
868597003822	Serine hydrolase; Region: Ser_hydrolase; cl17834
868597003823	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
868597003824	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
868597003825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
868597003826	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
868597003827	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
868597003828	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
868597003829	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
868597003830	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597003831	N-terminal plug; other site
868597003832	ligand-binding site [chemical binding]; other site
868597003833	Protein of unknown function (DUF445); Region: DUF445; pfam04286
868597003834	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
868597003835	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
868597003836	inhibitor-cofactor binding pocket; inhibition site
868597003837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597003838	catalytic residue [active]
868597003839	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
868597003840	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
868597003841	NAD(P) binding site [chemical binding]; other site
868597003842	catalytic residues [active]
868597003843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597003844	metabolite-proton symporter; Region: 2A0106; TIGR00883
868597003845	putative substrate translocation pore; other site
868597003846	Hemerythrin; Region: Hemerythrin; cd12107
868597003847	Fe binding site [ion binding]; other site
868597003848	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597003849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
868597003850	active site
868597003851	phosphorylation site [posttranslational modification]
868597003852	intermolecular recognition site; other site
868597003853	dimerization interface [polypeptide binding]; other site
868597003854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597003855	Response regulator receiver domain; Region: Response_reg; pfam00072
868597003856	active site
868597003857	phosphorylation site [posttranslational modification]
868597003858	intermolecular recognition site; other site
868597003859	dimerization interface [polypeptide binding]; other site
868597003860	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597003861	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597003862	metal binding site [ion binding]; metal-binding site
868597003863	active site
868597003864	I-site; other site
868597003865	MASE1; Region: MASE1; cl17823
868597003866	Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851
868597003867	MASE1; Region: MASE1; cl17823
868597003868	MASE1; Region: MASE1; cl17823
868597003869	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
868597003870	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
868597003871	Peptidase C26; Region: Peptidase_C26; pfam07722
868597003872	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
868597003873	catalytic triad [active]
868597003874	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
868597003875	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
868597003876	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
868597003877	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
868597003878	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
868597003879	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
868597003880	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597003881	Walker A/P-loop; other site
868597003882	ATP binding site [chemical binding]; other site
868597003883	Q-loop/lid; other site
868597003884	ABC transporter signature motif; other site
868597003885	Walker B; other site
868597003886	D-loop; other site
868597003887	H-loop/switch region; other site
868597003888	TOBE domain; Region: TOBE_2; pfam08402
868597003889	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
868597003890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597003891	dimer interface [polypeptide binding]; other site
868597003892	conserved gate region; other site
868597003893	putative PBP binding loops; other site
868597003894	ABC-ATPase subunit interface; other site
868597003895	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
868597003896	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597003897	dimer interface [polypeptide binding]; other site
868597003898	conserved gate region; other site
868597003899	putative PBP binding loops; other site
868597003900	ABC-ATPase subunit interface; other site
868597003901	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
868597003902	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
868597003903	NAD(P) binding site [chemical binding]; other site
868597003904	catalytic residues [active]
868597003905	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
868597003906	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
868597003907	oligomer interface [polypeptide binding]; other site
868597003908	metal binding site [ion binding]; metal-binding site
868597003909	metal binding site [ion binding]; metal-binding site
868597003910	putative Cl binding site [ion binding]; other site
868597003911	basic sphincter; other site
868597003912	hydrophobic gate; other site
868597003913	periplasmic entrance; other site
868597003914	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
868597003915	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
868597003916	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
868597003917	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
868597003918	Transporter associated domain; Region: CorC_HlyC; smart01091
868597003919	metal-binding heat shock protein; Provisional; Region: PRK00016
868597003920	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
868597003921	PhoH-like protein; Region: PhoH; pfam02562
868597003922	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597003923	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597003924	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
868597003925	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
868597003926	Walker A/P-loop; other site
868597003927	ATP binding site [chemical binding]; other site
868597003928	Q-loop/lid; other site
868597003929	ABC transporter signature motif; other site
868597003930	Walker B; other site
868597003931	D-loop; other site
868597003932	H-loop/switch region; other site
868597003933	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
868597003934	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
868597003935	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
868597003936	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
868597003937	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597003938	FeS/SAM binding site; other site
868597003939	TRAM domain; Region: TRAM; pfam01938
868597003940	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
868597003941	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
868597003942	putative C-terminal domain interface [polypeptide binding]; other site
868597003943	putative GSH binding site (G-site) [chemical binding]; other site
868597003944	putative dimer interface [polypeptide binding]; other site
868597003945	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
868597003946	dimer interface [polypeptide binding]; other site
868597003947	N-terminal domain interface [polypeptide binding]; other site
868597003948	putative substrate binding pocket (H-site) [chemical binding]; other site
868597003949	WYL domain; Region: WYL; pfam13280
868597003950	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
868597003951	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
868597003952	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597003953	catalytic residue [active]
868597003954	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
868597003955	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
868597003956	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
868597003957	[2Fe-2S] cluster binding site [ion binding]; other site
868597003958	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
868597003959	Qi binding site; other site
868597003960	intrachain domain interface; other site
868597003961	interchain domain interface [polypeptide binding]; other site
868597003962	cytochrome b; Provisional; Region: CYTB; MTH00156
868597003963	heme bH binding site [chemical binding]; other site
868597003964	heme bL binding site [chemical binding]; other site
868597003965	Qo binding site; other site
868597003966	interchain domain interface [polypeptide binding]; other site
868597003967	intrachain domain interface; other site
868597003968	Qi binding site; other site
868597003969	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
868597003970	Qo binding site; other site
868597003971	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
868597003972	stringent starvation protein A; Provisional; Region: sspA; PRK09481
868597003973	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
868597003974	C-terminal domain interface [polypeptide binding]; other site
868597003975	putative GSH binding site (G-site) [chemical binding]; other site
868597003976	dimer interface [polypeptide binding]; other site
868597003977	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
868597003978	dimer interface [polypeptide binding]; other site
868597003979	N-terminal domain interface [polypeptide binding]; other site
868597003980	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
868597003981	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
868597003982	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030
868597003983	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
868597003984	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
868597003985	dimerization interface [polypeptide binding]; other site
868597003986	active site
868597003987	Trm112p-like protein; Region: Trm112p; cl01066
868597003988	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
868597003989	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
868597003990	ATP-grasp domain; Region: ATP-grasp; pfam02222
868597003991	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
868597003992	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
868597003993	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
868597003994	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
868597003995	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
868597003996	putative GSH binding site [chemical binding]; other site
868597003997	catalytic residues [active]
868597003998	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597003999	NAD(P) binding site [chemical binding]; other site
868597004000	active site
868597004001	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
868597004002	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597004003	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
868597004004	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
868597004005	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
868597004006	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
868597004007	Type II transport protein GspH; Region: GspH; pfam12019
868597004008	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
868597004009	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
868597004010	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
868597004011	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
868597004012	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
868597004013	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
868597004014	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
868597004015	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
868597004016	Type II transport protein GspH; Region: GspH; pfam12019
868597004017	excinuclease ABC subunit B; Provisional; Region: PRK05298
868597004018	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
868597004019	ATP binding site [chemical binding]; other site
868597004020	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597004021	nucleotide binding region [chemical binding]; other site
868597004022	ATP-binding site [chemical binding]; other site
868597004023	Ultra-violet resistance protein B; Region: UvrB; pfam12344
868597004024	UvrB/uvrC motif; Region: UVR; pfam02151
868597004025	MltA-interacting protein MipA; Region: MipA; cl01504
868597004026	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597004027	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597004028	active site
868597004029	phosphorylation site [posttranslational modification]
868597004030	intermolecular recognition site; other site
868597004031	dimerization interface [polypeptide binding]; other site
868597004032	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597004033	DNA binding site [nucleotide binding]
868597004034	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597004035	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597004036	dimer interface [polypeptide binding]; other site
868597004037	phosphorylation site [posttranslational modification]
868597004038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597004039	Mg2+ binding site [ion binding]; other site
868597004040	G-X-G motif; other site
868597004041	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
868597004042	Competence protein; Region: Competence; pfam03772
868597004043	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
868597004044	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
868597004045	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
868597004046	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
868597004047	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
868597004048	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
868597004049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597004050	Walker A/P-loop; other site
868597004051	ATP binding site [chemical binding]; other site
868597004052	Q-loop/lid; other site
868597004053	ABC transporter signature motif; other site
868597004054	Walker B; other site
868597004055	D-loop; other site
868597004056	H-loop/switch region; other site
868597004057	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
868597004058	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
868597004059	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
868597004060	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
868597004061	Ligand binding site; other site
868597004062	oligomer interface; other site
868597004063	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
868597004064	Low molecular weight phosphatase family; Region: LMWPc; cd00115
868597004065	active site
868597004066	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
868597004067	NHL repeat; Region: NHL; pfam01436
868597004068	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
868597004069	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
868597004070	GIY-YIG motif/motif A; other site
868597004071	active site
868597004072	catalytic site [active]
868597004073	putative DNA binding site [nucleotide binding]; other site
868597004074	metal binding site [ion binding]; metal-binding site
868597004075	UvrB/uvrC motif; Region: UVR; pfam02151
868597004076	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
868597004077	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
868597004078	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
868597004079	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
868597004080	FtsX-like permease family; Region: FtsX; pfam02687
868597004081	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
868597004082	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
868597004083	Walker A/P-loop; other site
868597004084	ATP binding site [chemical binding]; other site
868597004085	Q-loop/lid; other site
868597004086	ABC transporter signature motif; other site
868597004087	Walker B; other site
868597004088	D-loop; other site
868597004089	H-loop/switch region; other site
868597004090	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597004091	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597004092	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
868597004093	nudix motif; other site
868597004094	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
868597004095	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
868597004096	Coenzyme A binding pocket [chemical binding]; other site
868597004097	Flavin Reductases; Region: FlaRed; cl00801
868597004098	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597004099	dimerization interface [polypeptide binding]; other site
868597004100	putative DNA binding site [nucleotide binding]; other site
868597004101	putative Zn2+ binding site [ion binding]; other site
868597004102	Prolyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ProS; COG0442
868597004103	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
868597004104	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
868597004105	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597004106	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597004107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597004108	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597004109	dimerization interface [polypeptide binding]; other site
868597004110	AAA domain; Region: AAA_33; pfam13671
868597004111	AAA domain; Region: AAA_17; pfam13207
868597004112	Cupin; Region: Cupin_6; pfam12852
868597004113	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597004114	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597004115	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597004116	camphor resistance protein CrcB; Provisional; Region: PRK14198
868597004117	sequence-specific DNA binding site [nucleotide binding]; other site
868597004118	Helix-turn-helix domain; Region: HTH_19; pfam12844
868597004119	salt bridge; other site
868597004120	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
868597004121	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
868597004122	apolar tunnel; other site
868597004123	heme binding site [chemical binding]; other site
868597004124	dimerization interface [polypeptide binding]; other site
868597004125	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
868597004126	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597004127	FeS/SAM binding site; other site
868597004128	HemN C-terminal domain; Region: HemN_C; pfam06969
868597004129	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
868597004130	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
868597004131	active site
868597004132	DNA binding site [nucleotide binding]
868597004133	Int/Topo IB signature motif; other site
868597004134	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
868597004135	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
868597004136	AAA domain; Region: AAA_24; pfam13479
868597004137	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
868597004138	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
868597004139	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597004140	sequence-specific DNA binding site [nucleotide binding]; other site
868597004141	salt bridge; other site
868597004142	replicative DNA helicase; Region: DnaB; TIGR00665
868597004143	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
868597004144	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
868597004145	Walker A motif; other site
868597004146	ATP binding site [chemical binding]; other site
868597004147	Walker B motif; other site
868597004148	NinB protein; Region: NinB; pfam05772
868597004149	Protein of unknown function (DUF968); Region: DUF968; pfam06147
868597004150	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
868597004151	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
868597004152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
868597004153	Terminase-like family; Region: Terminase_6; pfam03237
868597004154	The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633
868597004155	HeH/LEM domain; Region: HeH; pfam12949
868597004156	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
868597004157	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597004158	catalytic residue [active]
868597004159	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
868597004160	Sensors of blue-light using FAD; Region: BLUF; pfam04940
868597004161	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
868597004162	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
868597004163	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
868597004164	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
868597004165	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
868597004166	active site
868597004167	FMN binding site [chemical binding]; other site
868597004168	substrate binding site [chemical binding]; other site
868597004169	3Fe-4S cluster binding site [ion binding]; other site
868597004170	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
868597004171	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597004172	Coenzyme A binding pocket [chemical binding]; other site
868597004173	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597004174	hypothetical protein; Provisional; Region: PRK07236
868597004175	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
868597004176	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
868597004177	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
868597004178	rhodanese superfamily protein; Provisional; Region: PRK05320
868597004179	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
868597004180	active site residue [active]
868597004181	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
868597004182	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
868597004183	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
868597004184	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
868597004185	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
868597004186	Domain of unknown function DUF21; Region: DUF21; pfam01595
868597004187	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
868597004188	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
868597004189	Transporter associated domain; Region: CorC_HlyC; smart01091
868597004190	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
868597004191	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
868597004192	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
868597004193	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
868597004194	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
868597004195	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597004196	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
868597004197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597004198	Mg2+ binding site [ion binding]; other site
868597004199	G-X-G motif; other site
868597004200	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
868597004201	anchoring element; other site
868597004202	dimer interface [polypeptide binding]; other site
868597004203	ATP binding site [chemical binding]; other site
868597004204	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
868597004205	active site
868597004206	metal binding site [ion binding]; metal-binding site
868597004207	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
868597004208	CTP synthetase; Validated; Region: pyrG; PRK05380
868597004209	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
868597004210	Catalytic site [active]
868597004211	active site
868597004212	UTP binding site [chemical binding]; other site
868597004213	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
868597004214	active site
868597004215	putative oxyanion hole; other site
868597004216	catalytic triad [active]
868597004217	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
868597004218	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
868597004219	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
868597004220	enolase; Provisional; Region: eno; PRK00077
868597004221	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
868597004222	dimer interface [polypeptide binding]; other site
868597004223	metal binding site [ion binding]; metal-binding site
868597004224	substrate binding pocket [chemical binding]; other site
868597004225	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
868597004226	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
868597004227	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
868597004228	substrate binding site; other site
868597004229	dimer interface; other site
868597004230	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
868597004231	homotrimer interaction site [polypeptide binding]; other site
868597004232	zinc binding site [ion binding]; other site
868597004233	CDP-binding sites; other site
868597004234	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
868597004235	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
868597004236	Permutation of conserved domain; other site
868597004237	active site
868597004238	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
868597004239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
868597004240	Smr domain; Region: Smr; pfam01713
868597004241	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
868597004242	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
868597004243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597004244	S-adenosylmethionine binding site [chemical binding]; other site
868597004245	Predicted membrane protein [Function unknown]; Region: COG1238
868597004246	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
868597004247	Peptidase family M23; Region: Peptidase_M23; pfam01551
868597004248	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
868597004249	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
868597004250	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
868597004251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597004252	S-adenosylmethionine binding site [chemical binding]; other site
868597004253	FtsH Extracellular; Region: FtsH_ext; pfam06480
868597004254	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
868597004255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597004256	Walker A motif; other site
868597004257	ATP binding site [chemical binding]; other site
868597004258	Walker B motif; other site
868597004259	arginine finger; other site
868597004260	Peptidase family M41; Region: Peptidase_M41; pfam01434
868597004261	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
868597004262	Transposase; Region: HTH_Tnp_1; cl17663
868597004263	putative transposase OrfB; Reviewed; Region: PHA02517
868597004264	HTH-like domain; Region: HTH_21; pfam13276
868597004265	Integrase core domain; Region: rve; pfam00665
868597004266	Integrase core domain; Region: rve_3; pfam13683
868597004267	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
868597004268	dihydropteroate synthase; Region: DHPS; TIGR01496
868597004269	substrate binding pocket [chemical binding]; other site
868597004270	dimer interface [polypeptide binding]; other site
868597004271	inhibitor binding site; inhibition site
868597004272	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
868597004273	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
868597004274	active site
868597004275	bacterial Hfq-like; Region: Hfq; cd01716
868597004276	hexamer interface [polypeptide binding]; other site
868597004277	Sm1 motif; other site
868597004278	RNA binding site [nucleotide binding]; other site
868597004279	Sm2 motif; other site
868597004280	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
868597004281	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
868597004282	HflX GTPase family; Region: HflX; cd01878
868597004283	G1 box; other site
868597004284	GTP/Mg2+ binding site [chemical binding]; other site
868597004285	Switch I region; other site
868597004286	G2 box; other site
868597004287	G3 box; other site
868597004288	Switch II region; other site
868597004289	G4 box; other site
868597004290	G5 box; other site
868597004291	Competence-damaged protein; Region: CinA; cl00666
868597004292	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
868597004293	ABC1 family; Region: ABC1; cl17513
868597004294	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
868597004295	LexA repressor; Validated; Region: PRK00215
868597004296	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
868597004297	Catalytic site [active]
868597004298	recombinase A; Provisional; Region: recA; PRK09354
868597004299	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
868597004300	hexamer interface [polypeptide binding]; other site
868597004301	Walker A motif; other site
868597004302	ATP binding site [chemical binding]; other site
868597004303	Walker B motif; other site
868597004304	recombination regulator RecX; Reviewed; Region: recX; PRK00117
868597004305	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
868597004306	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
868597004307	motif 1; other site
868597004308	active site
868597004309	motif 2; other site
868597004310	motif 3; other site
868597004311	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
868597004312	DHHA1 domain; Region: DHHA1; pfam02272
868597004313	carbon storage regulator; Provisional; Region: PRK01712
868597004314	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597004315	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
868597004316	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597004317	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
868597004318	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
868597004319	dimer interface [polypeptide binding]; other site
868597004320	TPP-binding site [chemical binding]; other site
868597004321	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
868597004322	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597004323	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
868597004324	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
868597004325	FecR protein; Region: FecR; pfam04773
868597004326	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
868597004327	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597004328	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597004329	PhoD-like phosphatase; Region: PhoD; pfam09423
868597004330	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
868597004331	putative active site [active]
868597004332	putative metal binding site [ion binding]; other site
868597004333	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
868597004334	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
868597004335	Phosphoesterase family; Region: Phosphoesterase; pfam04185
868597004336	Domain of unknown function (DUF756); Region: DUF756; pfam05506
868597004337	Domain of unknown function (DUF756); Region: DUF756; pfam05506
868597004338	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597004339	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597004340	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597004341	Cytochrome c [Energy production and conversion]; Region: COG3258
868597004342	Cytochrome c; Region: Cytochrom_C; pfam00034
868597004343	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
868597004344	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
868597004345	Cytochrome c; Region: Cytochrom_C; pfam00034
868597004346	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
868597004347	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
868597004348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597004349	Major Facilitator Superfamily; Region: MFS_1; pfam07690
868597004350	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
868597004351	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
868597004352	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
868597004353	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597004354	N-terminal plug; other site
868597004355	ligand-binding site [chemical binding]; other site
868597004356	Pirin-related protein [General function prediction only]; Region: COG1741
868597004357	Pirin; Region: Pirin; pfam02678
868597004358	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
868597004359	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597004360	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597004361	dimerization interface [polypeptide binding]; other site
868597004362	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
868597004363	dimer interface [polypeptide binding]; other site
868597004364	substrate binding site [chemical binding]; other site
868597004365	ATP binding site [chemical binding]; other site
868597004366	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
868597004367	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
868597004368	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
868597004369	putative active site [active]
868597004370	PhoH-like protein; Region: PhoH; pfam02562
868597004371	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
868597004372	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
868597004373	catalytic triad [active]
868597004374	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
868597004375	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
868597004376	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
868597004377	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
868597004378	dihydrodipicolinate synthase; Region: dapA; TIGR00674
868597004379	dimer interface [polypeptide binding]; other site
868597004380	active site
868597004381	catalytic residue [active]
868597004382	Ferredoxin [Energy production and conversion]; Region: COG1146
868597004383	4Fe-4S binding domain; Region: Fer4; cl02805
868597004384	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
868597004385	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
868597004386	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597004387	putative substrate translocation pore; other site
868597004388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597004389	poly(A) polymerase; Region: pcnB; TIGR01942
868597004390	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
868597004391	active site
868597004392	NTP binding site [chemical binding]; other site
868597004393	metal binding triad [ion binding]; metal-binding site
868597004394	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
868597004395	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
868597004396	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
868597004397	catalytic center binding site [active]
868597004398	ATP binding site [chemical binding]; other site
868597004399	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
868597004400	oligomerization interface [polypeptide binding]; other site
868597004401	active site
868597004402	metal binding site [ion binding]; metal-binding site
868597004403	Pantoate-beta-alanine ligase; Region: PanC; cd00560
868597004404	pantoate--beta-alanine ligase; Region: panC; TIGR00018
868597004405	active site
868597004406	ATP-binding site [chemical binding]; other site
868597004407	pantoate-binding site; other site
868597004408	HXXH motif; other site
868597004409	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
868597004410	tetramerization interface [polypeptide binding]; other site
868597004411	active site
868597004412	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
868597004413	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
868597004414	active site
868597004415	dimer interface [polypeptide binding]; other site
868597004416	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
868597004417	dimer interface [polypeptide binding]; other site
868597004418	active site
868597004419	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
868597004420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597004421	active site
868597004422	phosphorylation site [posttranslational modification]
868597004423	intermolecular recognition site; other site
868597004424	dimerization interface [polypeptide binding]; other site
868597004425	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
868597004426	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597004427	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
868597004428	dimer interface [polypeptide binding]; other site
868597004429	phosphorylation site [posttranslational modification]
868597004430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597004431	ATP binding site [chemical binding]; other site
868597004432	Mg2+ binding site [ion binding]; other site
868597004433	G-X-G motif; other site
868597004434	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
868597004435	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
868597004436	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
868597004437	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
868597004438	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
868597004439	active site
868597004440	response regulator; Provisional; Region: PRK09483
868597004441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597004442	active site
868597004443	phosphorylation site [posttranslational modification]
868597004444	intermolecular recognition site; other site
868597004445	dimerization interface [polypeptide binding]; other site
868597004446	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597004447	DNA binding residues [nucleotide binding]
868597004448	dimerization interface [polypeptide binding]; other site
868597004449	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
868597004450	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
868597004451	active site
868597004452	intersubunit interface [polypeptide binding]; other site
868597004453	catalytic residue [active]
868597004454	phosphogluconate dehydratase; Validated; Region: PRK09054
868597004455	6-phosphogluconate dehydratase; Region: edd; TIGR01196
868597004456	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
868597004457	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
868597004458	putative active site [active]
868597004459	glucokinase; Provisional; Region: glk; PRK00292
868597004460	glucokinase, proteobacterial type; Region: glk; TIGR00749
868597004461	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
868597004462	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
868597004463	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
868597004464	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
868597004465	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
868597004466	Walker A/P-loop; other site
868597004467	ATP binding site [chemical binding]; other site
868597004468	Q-loop/lid; other site
868597004469	ABC transporter signature motif; other site
868597004470	Walker B; other site
868597004471	D-loop; other site
868597004472	H-loop/switch region; other site
868597004473	TOBE domain; Region: TOBE_2; pfam08402
868597004474	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
868597004475	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
868597004476	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
868597004477	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
868597004478	Iron-sulfur protein interface; other site
868597004479	proximal quinone binding site [chemical binding]; other site
868597004480	SdhD (CybS) interface [polypeptide binding]; other site
868597004481	proximal heme binding site [chemical binding]; other site
868597004482	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
868597004483	putative SdhC subunit interface [polypeptide binding]; other site
868597004484	putative proximal heme binding site [chemical binding]; other site
868597004485	putative Iron-sulfur protein interface [polypeptide binding]; other site
868597004486	putative proximal quinone binding site; other site
868597004487	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
868597004488	L-aspartate oxidase; Provisional; Region: PRK06175
868597004489	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
868597004490	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
868597004491	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
868597004492	catalytic loop [active]
868597004493	iron binding site [ion binding]; other site
868597004494	Uncharacterized conserved protein [Function unknown]; Region: COG2938
868597004495	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
868597004496	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597004497	FtsX-like permease family; Region: FtsX; pfam02687
868597004498	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
868597004499	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
868597004500	Walker A/P-loop; other site
868597004501	ATP binding site [chemical binding]; other site
868597004502	Q-loop/lid; other site
868597004503	ABC transporter signature motif; other site
868597004504	Walker B; other site
868597004505	D-loop; other site
868597004506	H-loop/switch region; other site
868597004507	oxidative damage protection protein; Provisional; Region: PRK05408
868597004508	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
868597004509	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
868597004510	minor groove reading motif; other site
868597004511	helix-hairpin-helix signature motif; other site
868597004512	substrate binding pocket [chemical binding]; other site
868597004513	active site
868597004514	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
868597004515	DNA binding and oxoG recognition site [nucleotide binding]
868597004516	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
868597004517	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
868597004518	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
868597004519	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
868597004520	heat shock protein 90; Provisional; Region: PRK05218
868597004521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597004522	ATP binding site [chemical binding]; other site
868597004523	Mg2+ binding site [ion binding]; other site
868597004524	G-X-G motif; other site
868597004525	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
868597004526	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597004527	S-adenosylmethionine binding site [chemical binding]; other site
868597004528	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
868597004529	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
868597004530	active site
868597004531	(T/H)XGH motif; other site
868597004532	ferredoxin; Validated; Region: PRK07118
868597004533	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
868597004534	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
868597004535	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
868597004536	psiF repeat; Region: PsiF_repeat; pfam07769
868597004537	hypothetical protein; Provisional; Region: PRK11505
868597004538	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597004539	dimerization interface [polypeptide binding]; other site
868597004540	putative DNA binding site [nucleotide binding]; other site
868597004541	putative Zn2+ binding site [ion binding]; other site
868597004542	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
868597004543	putative hydrophobic ligand binding site [chemical binding]; other site
868597004544	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
868597004545	active site
868597004546	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
868597004547	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597004548	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597004549	NHL repeat; Region: NHL; pfam01436
868597004550	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
868597004551	active site
868597004552	metal binding site [ion binding]; metal-binding site
868597004553	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
868597004554	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
868597004555	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
868597004556	dimer interface [polypeptide binding]; other site
868597004557	substrate binding site [chemical binding]; other site
868597004558	metal binding sites [ion binding]; metal-binding site
868597004559	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
868597004560	DNA photolyase; Region: DNA_photolyase; pfam00875
868597004561	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
868597004562	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
868597004563	ligand binding site [chemical binding]; other site
868597004564	LysR family transcriptional regulator; Provisional; Region: PRK14997
868597004565	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597004566	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597004567	putative effector binding pocket; other site
868597004568	dimerization interface [polypeptide binding]; other site
868597004569	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
868597004570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597004571	NAD(P) binding site [chemical binding]; other site
868597004572	active site
868597004573	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597004574	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597004575	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597004576	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
868597004577	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
868597004578	C factor cell-cell signaling protein; Provisional; Region: PRK09009
868597004579	NADP binding site [chemical binding]; other site
868597004580	substrate binding site [chemical binding]; other site
868597004581	active site
868597004582	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
868597004583	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
868597004584	putative catalytic site [active]
868597004585	putative metal binding site [ion binding]; other site
868597004586	putative phosphate binding site [ion binding]; other site
868597004587	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
868597004588	Cytochrome P450; Region: p450; cl12078
868597004589	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
868597004590	Autoinducer binding domain; Region: Autoind_bind; pfam03472
868597004591	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597004592	DNA binding residues [nucleotide binding]
868597004593	chaperone protein HchA; Provisional; Region: PRK04155
868597004594	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
868597004595	conserved cys residue [active]
868597004596	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
868597004597	Cytochrome P450; Region: p450; cl12078
868597004598	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
868597004599	Putative serine esterase (DUF676); Region: DUF676; pfam05057
868597004600	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
868597004601	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597004602	Coenzyme A binding pocket [chemical binding]; other site
868597004603	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597004604	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
868597004605	Coenzyme A binding pocket [chemical binding]; other site
868597004606	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
868597004607	SmpB-tmRNA interface; other site
868597004608	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
868597004609	putative coenzyme Q binding site [chemical binding]; other site
868597004610	hypothetical protein; Validated; Region: PRK01777
868597004611	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
868597004612	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
868597004613	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
868597004614	metal binding site 2 [ion binding]; metal-binding site
868597004615	putative DNA binding helix; other site
868597004616	metal binding site 1 [ion binding]; metal-binding site
868597004617	dimer interface [polypeptide binding]; other site
868597004618	structural Zn2+ binding site [ion binding]; other site
868597004619	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
868597004620	active site
868597004621	catalytic triad [active]
868597004622	oxyanion hole [active]
868597004623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597004624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597004625	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597004626	dimerization interface [polypeptide binding]; other site
868597004627	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
868597004628	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
868597004629	Walker A/P-loop; other site
868597004630	ATP binding site [chemical binding]; other site
868597004631	Q-loop/lid; other site
868597004632	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
868597004633	ABC transporter signature motif; other site
868597004634	Walker B; other site
868597004635	D-loop; other site
868597004636	H-loop/switch region; other site
868597004637	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
868597004638	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
868597004639	GrpE; Region: GrpE; pfam01025
868597004640	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
868597004641	dimer interface [polypeptide binding]; other site
868597004642	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
868597004643	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
868597004644	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
868597004645	nucleotide binding site [chemical binding]; other site
868597004646	chaperone protein DnaJ; Provisional; Region: PRK10767
868597004647	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
868597004648	HSP70 interaction site [polypeptide binding]; other site
868597004649	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
868597004650	substrate binding site [polypeptide binding]; other site
868597004651	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
868597004652	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
868597004653	dimer interface [polypeptide binding]; other site
868597004654	Cupin domain; Region: Cupin_2; pfam07883
868597004655	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
868597004656	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597004657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597004658	Major Facilitator Superfamily; Region: MFS_1; pfam07690
868597004659	putative substrate translocation pore; other site
868597004660	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
868597004661	dimer interface [polypeptide binding]; other site
868597004662	pyridoxamine kinase; Validated; Region: PRK05756
868597004663	pyridoxal binding site [chemical binding]; other site
868597004664	ATP binding site [chemical binding]; other site
868597004665	prephenate dehydrogenase; Provisional; Region: PRK08818
868597004666	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826
868597004667	prephenate dehydrogenase; Validated; Region: PRK08507
868597004668	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
868597004669	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
868597004670	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
868597004671	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597004672	Walker A/P-loop; other site
868597004673	ATP binding site [chemical binding]; other site
868597004674	Q-loop/lid; other site
868597004675	ABC transporter signature motif; other site
868597004676	Walker B; other site
868597004677	D-loop; other site
868597004678	H-loop/switch region; other site
868597004679	Uncharacterized conserved protein [Function unknown]; Region: COG1739
868597004680	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
868597004681	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
868597004682	RNA polymerase sigma factor; Provisional; Region: PRK12513
868597004683	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597004684	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597004685	DNA binding residues [nucleotide binding]
868597004686	GAF domain; Region: GAF; cl17456
868597004687	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
868597004688	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
868597004689	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597004690	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597004691	metal binding site [ion binding]; metal-binding site
868597004692	active site
868597004693	I-site; other site
868597004694	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597004695	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
868597004696	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
868597004697	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
868597004698	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597004699	catalytic residue [active]
868597004700	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
868597004701	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
868597004702	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
868597004703	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
868597004704	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
868597004705	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
868597004706	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
868597004707	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
868597004708	Protein of unknown function (DUF3631); Region: DUF3631; pfam12307
868597004709	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
868597004710	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
868597004711	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
868597004712	Protein export membrane protein; Region: SecD_SecF; pfam02355
868597004713	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
868597004714	Transposase; Region: HTH_Tnp_1; cl17663
868597004715	putative transposase OrfB; Reviewed; Region: PHA02517
868597004716	HTH-like domain; Region: HTH_21; pfam13276
868597004717	Integrase core domain; Region: rve; pfam00665
868597004718	Integrase core domain; Region: rve_3; pfam13683
868597004719	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
868597004720	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
868597004721	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
868597004722	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
868597004723	Response regulator receiver domain; Region: Response_reg; pfam00072
868597004724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597004725	active site
868597004726	phosphorylation site [posttranslational modification]
868597004727	dimerization interface [polypeptide binding]; other site
868597004728	PAS domain S-box; Region: sensory_box; TIGR00229
868597004729	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597004730	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597004731	metal binding site [ion binding]; metal-binding site
868597004732	active site
868597004733	I-site; other site
868597004734	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597004735	HI0933-like protein; Region: HI0933_like; pfam03486
868597004736	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
868597004737	Domain of unknown function (DUF1853); Region: DUF1853; cl01545
868597004738	YaeQ protein; Region: YaeQ; pfam07152
868597004739	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
868597004740	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
868597004741	active site
868597004742	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
868597004743	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
868597004744	DNA-binding site [nucleotide binding]; DNA binding site
868597004745	RNA-binding motif; other site
868597004746	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
868597004747	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
868597004748	putative C-terminal domain interface [polypeptide binding]; other site
868597004749	putative GSH binding site (G-site) [chemical binding]; other site
868597004750	putative dimer interface [polypeptide binding]; other site
868597004751	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
868597004752	putative N-terminal domain interface [polypeptide binding]; other site
868597004753	putative dimer interface [polypeptide binding]; other site
868597004754	putative substrate binding pocket (H-site) [chemical binding]; other site
868597004755	hypothetical protein; Validated; Region: PRK00029
868597004756	Uncharacterized conserved protein [Function unknown]; Region: COG0397
868597004757	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
868597004758	active site
868597004759	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
868597004760	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
868597004761	ATP binding site [chemical binding]; other site
868597004762	Mg++ binding site [ion binding]; other site
868597004763	motif III; other site
868597004764	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597004765	nucleotide binding region [chemical binding]; other site
868597004766	ATP-binding site [chemical binding]; other site
868597004767	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
868597004768	putative RNA binding site [nucleotide binding]; other site
868597004769	Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252
868597004770	Predicted membrane protein [Function unknown]; Region: COG2855
868597004771	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
868597004772	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597004773	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
868597004774	putative dimerization interface [polypeptide binding]; other site
868597004775	ABC transporter ATPase component; Reviewed; Region: PRK11147
868597004776	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
868597004777	Walker A/P-loop; other site
868597004778	ATP binding site [chemical binding]; other site
868597004779	Q-loop/lid; other site
868597004780	ABC transporter signature motif; other site
868597004781	Walker B; other site
868597004782	D-loop; other site
868597004783	H-loop/switch region; other site
868597004784	ABC transporter; Region: ABC_tran_2; pfam12848
868597004785	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
868597004786	Cytochrome c553 [Energy production and conversion]; Region: COG2863
868597004787	Cytochrome c; Region: Cytochrom_C; cl11414
868597004788	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597004789	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597004790	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597004791	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
868597004792	Protein export membrane protein; Region: SecD_SecF; cl14618
868597004793	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
868597004794	Protein export membrane protein; Region: SecD_SecF; cl14618
868597004795	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
868597004796	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
868597004797	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597004798	Coenzyme A binding pocket [chemical binding]; other site
868597004799	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
868597004800	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
868597004801	putative active site; other site
868597004802	catalytic triad [active]
868597004803	putative dimer interface [polypeptide binding]; other site
868597004804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
868597004805	Transposase; Region: DEDD_Tnp_IS110; pfam01548
868597004806	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
868597004807	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
868597004808	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
868597004809	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
868597004810	cytidylate kinase; Provisional; Region: cmk; PRK00023
868597004811	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
868597004812	CMP-binding site; other site
868597004813	The sites determining sugar specificity; other site
868597004814	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
868597004815	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
868597004816	RNA binding site [nucleotide binding]; other site
868597004817	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
868597004818	RNA binding site [nucleotide binding]; other site
868597004819	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
868597004820	RNA binding site [nucleotide binding]; other site
868597004821	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
868597004822	RNA binding site [nucleotide binding]; other site
868597004823	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
868597004824	RNA binding site [nucleotide binding]; other site
868597004825	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
868597004826	RNA binding site [nucleotide binding]; other site
868597004827	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
868597004828	IHF dimer interface [polypeptide binding]; other site
868597004829	IHF - DNA interface [nucleotide binding]; other site
868597004830	tetratricopeptide repeat protein; Provisional; Region: PRK11788
868597004831	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597004832	binding surface
868597004833	TPR motif; other site
868597004834	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
868597004835	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
868597004836	Mg++ binding site [ion binding]; other site
868597004837	putative catalytic motif [active]
868597004838	putative substrate binding site [chemical binding]; other site
868597004839	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
868597004840	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
868597004841	NAD(P) binding site [chemical binding]; other site
868597004842	homodimer interface [polypeptide binding]; other site
868597004843	substrate binding site [chemical binding]; other site
868597004844	active site
868597004845	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
868597004846	active site
868597004847	tetramer interface; other site
868597004848	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
868597004849	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
868597004850	dimer interface [polypeptide binding]; other site
868597004851	active site
868597004852	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
868597004853	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
868597004854	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
868597004855	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597004856	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597004857	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
868597004858	active site
868597004859	multimer interface [polypeptide binding]; other site
868597004860	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
868597004861	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597004862	FeS/SAM binding site; other site
868597004863	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597004864	binding surface
868597004865	Tetratricopeptide repeat; Region: TPR_16; pfam13432
868597004866	TPR motif; other site
868597004867	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
868597004868	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597004869	non-specific DNA binding site [nucleotide binding]; other site
868597004870	salt bridge; other site
868597004871	sequence-specific DNA binding site [nucleotide binding]; other site
868597004872	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
868597004873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
868597004874	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
868597004875	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
868597004876	Trp docking motif [polypeptide binding]; other site
868597004877	GTP-binding protein Der; Reviewed; Region: PRK00093
868597004878	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
868597004879	G1 box; other site
868597004880	GTP/Mg2+ binding site [chemical binding]; other site
868597004881	Switch I region; other site
868597004882	G2 box; other site
868597004883	Switch II region; other site
868597004884	G3 box; other site
868597004885	G4 box; other site
868597004886	G5 box; other site
868597004887	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
868597004888	G1 box; other site
868597004889	GTP/Mg2+ binding site [chemical binding]; other site
868597004890	Switch I region; other site
868597004891	G2 box; other site
868597004892	G3 box; other site
868597004893	Switch II region; other site
868597004894	G4 box; other site
868597004895	G5 box; other site
868597004896	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762
868597004897	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
868597004898	active site residue [active]
868597004899	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
868597004900	ATP binding site [chemical binding]; other site
868597004901	substrate interface [chemical binding]; other site
868597004902	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
868597004903	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
868597004904	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
868597004905	TrkA-N domain; Region: TrkA_N; pfam02254
868597004906	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
868597004907	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
868597004908	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
868597004909	homodimer interface [polypeptide binding]; other site
868597004910	NADP binding site [chemical binding]; other site
868597004911	substrate binding site [chemical binding]; other site
868597004912	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
868597004913	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
868597004914	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
868597004915	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
868597004916	active site
868597004917	GMP synthase; Reviewed; Region: guaA; PRK00074
868597004918	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
868597004919	AMP/PPi binding site [chemical binding]; other site
868597004920	candidate oxyanion hole; other site
868597004921	catalytic triad [active]
868597004922	potential glutamine specificity residues [chemical binding]; other site
868597004923	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
868597004924	ATP Binding subdomain [chemical binding]; other site
868597004925	Ligand Binding sites [chemical binding]; other site
868597004926	Dimerization subdomain; other site
868597004927	Methyltransferase domain; Region: Methyltransf_26; pfam13659
868597004928	DEAD-like helicases superfamily; Region: DEXDc; smart00487
868597004929	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
868597004930	ATP binding site [chemical binding]; other site
868597004931	putative Mg++ binding site [ion binding]; other site
868597004932	Pseudomurein-binding repeat; Region: PMBR; pfam09373
868597004933	T5orf172 domain; Region: T5orf172; pfam10544
868597004934	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597004935	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597004936	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597004937	putative effector binding pocket; other site
868597004938	dimerization interface [polypeptide binding]; other site
868597004939	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
868597004940	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
868597004941	potential catalytic triad [active]
868597004942	conserved cys residue [active]
868597004943	Zeta toxin; Region: Zeta_toxin; pfam06414
868597004944	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
868597004945	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
868597004946	Zn binding site [ion binding]; other site
868597004947	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
868597004948	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
868597004949	NAD binding site [chemical binding]; other site
868597004950	homotetramer interface [polypeptide binding]; other site
868597004951	homodimer interface [polypeptide binding]; other site
868597004952	substrate binding site [chemical binding]; other site
868597004953	active site
868597004954	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
868597004955	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
868597004956	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
868597004957	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
868597004958	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
868597004959	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
868597004960	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
868597004961	catalytic site [active]
868597004962	Helix-turn-helix domain; Region: HTH_17; pfam12728
868597004963	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
868597004964	putative hydrophobic ligand binding site [chemical binding]; other site
868597004965	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597004966	dimerization interface [polypeptide binding]; other site
868597004967	putative DNA binding site [nucleotide binding]; other site
868597004968	putative Zn2+ binding site [ion binding]; other site
868597004969	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
868597004970	putative hydrophobic ligand binding site [chemical binding]; other site
868597004971	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
868597004972	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597004973	Coenzyme A binding pocket [chemical binding]; other site
868597004974	myosin-cross-reactive antigen; Provisional; Region: PRK13977
868597004975	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
868597004976	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
868597004977	conserved cys residue [active]
868597004978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597004979	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597004980	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
868597004981	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597004982	N-terminal plug; other site
868597004983	ligand-binding site [chemical binding]; other site
868597004984	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597004985	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
868597004986	Protein of unknown function (DUF3088); Region: DUF3088; pfam11287
868597004987	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
868597004988	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
868597004989	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
868597004990	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
868597004991	active site
868597004992	non-prolyl cis peptide bond; other site
868597004993	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
868597004994	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
868597004995	metal binding site [ion binding]; metal-binding site
868597004996	putative dimer interface [polypeptide binding]; other site
868597004997	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597004998	Coenzyme A binding pocket [chemical binding]; other site
868597004999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597005000	dimer interface [polypeptide binding]; other site
868597005001	conserved gate region; other site
868597005002	putative PBP binding loops; other site
868597005003	ABC-ATPase subunit interface; other site
868597005004	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
868597005005	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
868597005006	Walker A/P-loop; other site
868597005007	ATP binding site [chemical binding]; other site
868597005008	Q-loop/lid; other site
868597005009	ABC transporter signature motif; other site
868597005010	Walker B; other site
868597005011	D-loop; other site
868597005012	H-loop/switch region; other site
868597005013	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
868597005014	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
868597005015	substrate binding pocket [chemical binding]; other site
868597005016	membrane-bound complex binding site; other site
868597005017	hinge residues; other site
868597005018	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
868597005019	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
868597005020	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
868597005021	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597005022	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597005023	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
868597005024	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597005025	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
868597005026	classical (c) SDRs; Region: SDR_c; cd05233
868597005027	NAD(P) binding site [chemical binding]; other site
868597005028	active site
868597005029	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597005030	Coenzyme A binding pocket [chemical binding]; other site
868597005031	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
868597005032	active site
868597005033	ATP binding site [chemical binding]; other site
868597005034	Phosphotransferase enzyme family; Region: APH; pfam01636
868597005035	antibiotic binding site [chemical binding]; other site
868597005036	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597005037	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597005038	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
868597005039	Phosphotransferase enzyme family; Region: APH; pfam01636
868597005040	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
868597005041	EamA-like transporter family; Region: EamA; cl17759
868597005042	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
868597005043	FAD binding domain; Region: FAD_binding_4; pfam01565
868597005044	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
868597005045	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
868597005046	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
868597005047	quinone interaction residues [chemical binding]; other site
868597005048	active site
868597005049	catalytic residues [active]
868597005050	FMN binding site [chemical binding]; other site
868597005051	substrate binding site [chemical binding]; other site
868597005052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597005053	S-adenosylmethionine binding site [chemical binding]; other site
868597005054	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
868597005055	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
868597005056	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597005057	NAD(P) binding site [chemical binding]; other site
868597005058	active site
868597005059	aldehyde dehydrogenase family 7 member; Region: PLN02315
868597005060	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
868597005061	tetrameric interface [polypeptide binding]; other site
868597005062	NAD binding site [chemical binding]; other site
868597005063	catalytic residues [active]
868597005064	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
868597005065	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597005066	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
868597005067	Coenzyme A binding pocket [chemical binding]; other site
868597005068	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
868597005069	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597005070	non-specific DNA binding site [nucleotide binding]; other site
868597005071	salt bridge; other site
868597005072	sequence-specific DNA binding site [nucleotide binding]; other site
868597005073	Domain of unknown function (DUF955); Region: DUF955; cl01076
868597005074	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
868597005075	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
868597005076	inhibitor site; inhibition site
868597005077	active site
868597005078	dimer interface [polypeptide binding]; other site
868597005079	catalytic residue [active]
868597005080	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
868597005081	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
868597005082	Coenzyme A binding pocket [chemical binding]; other site
868597005083	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
868597005084	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
868597005085	Helix-turn-helix domain; Region: HTH_18; pfam12833
868597005086	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597005087	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
868597005088	Ligand Binding Site [chemical binding]; other site
868597005089	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
868597005090	Domain of unknown function DUF11; Region: DUF11; pfam01345
868597005091	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
868597005092	ligand binding site [chemical binding]; other site
868597005093	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
868597005094	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
868597005095	ligand binding site [chemical binding]; other site
868597005096	putative rSAM target protein, CGCGG family; Region: target_X_rSAM; TIGR03995
868597005097	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
868597005098	Response regulator receiver domain; Region: Response_reg; pfam00072
868597005099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005100	active site
868597005101	phosphorylation site [posttranslational modification]
868597005102	intermolecular recognition site; other site
868597005103	dimerization interface [polypeptide binding]; other site
868597005104	PAS domain S-box; Region: sensory_box; TIGR00229
868597005105	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597005106	putative active site [active]
868597005107	histidine kinase; Provisional; Region: PRK13557
868597005108	heme pocket [chemical binding]; other site
868597005109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005110	ATP binding site [chemical binding]; other site
868597005111	G-X-G motif; other site
868597005112	GAF domain; Region: GAF_2; pfam13185
868597005113	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
868597005114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597005115	dimer interface [polypeptide binding]; other site
868597005116	phosphorylation site [posttranslational modification]
868597005117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005118	ATP binding site [chemical binding]; other site
868597005119	Mg2+ binding site [ion binding]; other site
868597005120	G-X-G motif; other site
868597005121	Response regulator receiver domain; Region: Response_reg; pfam00072
868597005122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005123	active site
868597005124	phosphorylation site [posttranslational modification]
868597005125	intermolecular recognition site; other site
868597005126	dimerization interface [polypeptide binding]; other site
868597005127	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597005128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005129	active site
868597005130	phosphorylation site [posttranslational modification]
868597005131	intermolecular recognition site; other site
868597005132	dimerization interface [polypeptide binding]; other site
868597005133	Response regulator receiver domain; Region: Response_reg; pfam00072
868597005134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005135	active site
868597005136	phosphorylation site [posttranslational modification]
868597005137	intermolecular recognition site; other site
868597005138	dimerization interface [polypeptide binding]; other site
868597005139	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
868597005140	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
868597005141	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
868597005142	CheB methylesterase; Region: CheB_methylest; pfam01339
868597005143	Response regulator receiver domain; Region: Response_reg; pfam00072
868597005144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005145	active site
868597005146	phosphorylation site [posttranslational modification]
868597005147	intermolecular recognition site; other site
868597005148	dimerization interface [polypeptide binding]; other site
868597005149	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597005150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597005151	dimer interface [polypeptide binding]; other site
868597005152	phosphorylation site [posttranslational modification]
868597005153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005154	ATP binding site [chemical binding]; other site
868597005155	Mg2+ binding site [ion binding]; other site
868597005156	G-X-G motif; other site
868597005157	Sensors of blue-light using FAD; Region: BLUF; pfam04940
868597005158	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597005159	dimerization interface [polypeptide binding]; other site
868597005160	putative DNA binding site [nucleotide binding]; other site
868597005161	putative Zn2+ binding site [ion binding]; other site
868597005162	Predicted transporter component [General function prediction only]; Region: COG2391
868597005163	Predicted transporter component [General function prediction only]; Region: COG2391
868597005164	Sulphur transport; Region: Sulf_transp; pfam04143
868597005165	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
868597005166	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
868597005167	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597005168	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597005169	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597005170	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
868597005171	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
868597005172	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
868597005173	putative catalytic residues [active]
868597005174	putative nucleotide binding site [chemical binding]; other site
868597005175	putative aspartate binding site [chemical binding]; other site
868597005176	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
868597005177	dimer interface [polypeptide binding]; other site
868597005178	putative threonine allosteric regulatory site; other site
868597005179	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
868597005180	putative threonine allosteric regulatory site; other site
868597005181	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
868597005182	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
868597005183	homoserine kinase; Provisional; Region: PRK01212
868597005184	threonine synthase; Validated; Region: PRK09225
868597005185	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
868597005186	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597005187	catalytic residue [active]
868597005188	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
868597005189	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
868597005190	ligand binding site [chemical binding]; other site
868597005191	flexible hinge region; other site
868597005192	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
868597005193	putative switch regulator; other site
868597005194	non-specific DNA interactions [nucleotide binding]; other site
868597005195	DNA binding site [nucleotide binding]
868597005196	sequence specific DNA binding site [nucleotide binding]; other site
868597005197	putative cAMP binding site [chemical binding]; other site
868597005198	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
868597005199	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
868597005200	dimer interface [polypeptide binding]; other site
868597005201	motif 1; other site
868597005202	active site
868597005203	motif 2; other site
868597005204	motif 3; other site
868597005205	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
868597005206	anticodon binding site; other site
868597005207	Trp repressor protein; Region: Trp_repressor; cl17266
868597005208	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
868597005209	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
868597005210	HisG, C-terminal domain; Region: HisG_C; cl06867
868597005211	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
868597005212	histidinol dehydrogenase; Region: hisD; TIGR00069
868597005213	NAD binding site [chemical binding]; other site
868597005214	dimerization interface [polypeptide binding]; other site
868597005215	product binding site; other site
868597005216	substrate binding site [chemical binding]; other site
868597005217	zinc binding site [ion binding]; other site
868597005218	catalytic residues [active]
868597005219	histidinol-phosphate aminotransferase; Provisional; Region: PRK04781
868597005220	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597005221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597005222	homodimer interface [polypeptide binding]; other site
868597005223	catalytic residue [active]
868597005224	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
868597005225	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597005226	active site
868597005227	motif I; other site
868597005228	motif II; other site
868597005229	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
868597005230	putative active site pocket [active]
868597005231	4-fold oligomerization interface [polypeptide binding]; other site
868597005232	metal binding residues [ion binding]; metal-binding site
868597005233	3-fold/trimer interface [polypeptide binding]; other site
868597005234	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
868597005235	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
868597005236	putative active site [active]
868597005237	oxyanion strand; other site
868597005238	catalytic triad [active]
868597005239	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
868597005240	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
868597005241	catalytic residues [active]
868597005242	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
868597005243	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
868597005244	substrate binding site [chemical binding]; other site
868597005245	glutamase interaction surface [polypeptide binding]; other site
868597005246	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
868597005247	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
868597005248	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
868597005249	metal binding site [ion binding]; metal-binding site
868597005250	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
868597005251	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
868597005252	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
868597005253	active site
868597005254	metal binding site [ion binding]; metal-binding site
868597005255	Glucokinase; Region: Glucokinase; cl17310
868597005256	glucokinase, proteobacterial type; Region: glk; TIGR00749
868597005257	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
868597005258	active site
868597005259	dimer interface [polypeptide binding]; other site
868597005260	catalytic nucleophile [active]
868597005261	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
868597005262	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597005263	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597005264	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
868597005265	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
868597005266	metal-binding site [ion binding]
868597005267	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
868597005268	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
868597005269	metal-binding site [ion binding]
868597005270	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
868597005271	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597005272	motif II; other site
868597005273	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
868597005274	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
868597005275	DNA binding residues [nucleotide binding]
868597005276	dimer interface [polypeptide binding]; other site
868597005277	copper binding site [ion binding]; other site
868597005278	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
868597005279	metal-binding site [ion binding]
868597005280	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
868597005281	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597005282	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597005283	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
868597005284	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
868597005285	Transcriptional regulators [Transcription]; Region: PurR; COG1609
868597005286	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
868597005287	DNA binding site [nucleotide binding]
868597005288	domain linker motif; other site
868597005289	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
868597005290	putative ligand binding site [chemical binding]; other site
868597005291	putative dimerization interface [polypeptide binding]; other site
868597005292	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
868597005293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597005294	putative substrate translocation pore; other site
868597005295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597005296	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
868597005297	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
868597005298	putative substrate binding site [chemical binding]; other site
868597005299	putative ATP binding site [chemical binding]; other site
868597005300	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
868597005301	dimerization interface [polypeptide binding]; other site
868597005302	putative active cleft [active]
868597005303	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
868597005304	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
868597005305	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
868597005306	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
868597005307	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
868597005308	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
868597005309	Cupin domain; Region: Cupin_2; cl17218
868597005310	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
868597005311	intersubunit interface [polypeptide binding]; other site
868597005312	active site
868597005313	Zn2+ binding site [ion binding]; other site
868597005314	amino acid transporter; Region: 2A0306; TIGR00909
868597005315	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
868597005316	amino acid transporter; Region: 2A0306; TIGR00909
868597005317	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
868597005318	nudix motif; other site
868597005319	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
868597005320	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
868597005321	ligand binding site [chemical binding]; other site
868597005322	NAD binding site [chemical binding]; other site
868597005323	tetramer interface [polypeptide binding]; other site
868597005324	catalytic site [active]
868597005325	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
868597005326	L-serine binding site [chemical binding]; other site
868597005327	ACT domain interface; other site
868597005328	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
868597005329	FAD binding domain; Region: FAD_binding_4; pfam01565
868597005330	Protein of unknown function (DUF2388); Region: DUF2388; cl09731
868597005331	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
868597005332	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
868597005333	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597005334	HAMP domain; Region: HAMP; pfam00672
868597005335	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597005336	dimer interface [polypeptide binding]; other site
868597005337	phosphorylation site [posttranslational modification]
868597005338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005339	ATP binding site [chemical binding]; other site
868597005340	Mg2+ binding site [ion binding]; other site
868597005341	G-X-G motif; other site
868597005342	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597005343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005344	active site
868597005345	phosphorylation site [posttranslational modification]
868597005346	intermolecular recognition site; other site
868597005347	dimerization interface [polypeptide binding]; other site
868597005348	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597005349	DNA binding site [nucleotide binding]
868597005350	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
868597005351	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597005352	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597005353	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
868597005354	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
868597005355	Predicted membrane protein [Function unknown]; Region: COG3650
868597005356	elongation factor P; Provisional; Region: PRK04542
868597005357	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
868597005358	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
868597005359	RNA binding site [nucleotide binding]; other site
868597005360	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
868597005361	RNA binding site [nucleotide binding]; other site
868597005362	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
868597005363	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
868597005364	NAD binding site [chemical binding]; other site
868597005365	homodimer interface [polypeptide binding]; other site
868597005366	homotetramer interface [polypeptide binding]; other site
868597005367	active site
868597005368	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
868597005369	active site
868597005370	catalytic residues [active]
868597005371	metal binding site [ion binding]; metal-binding site
868597005372	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
868597005373	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597005374	enoyl-CoA hydratase; Provisional; Region: PRK05995
868597005375	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
868597005376	substrate binding site [chemical binding]; other site
868597005377	oxyanion hole (OAH) forming residues; other site
868597005378	trimer interface [polypeptide binding]; other site
868597005379	FeoA domain; Region: FeoA; pfam04023
868597005380	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
868597005381	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
868597005382	G1 box; other site
868597005383	GTP/Mg2+ binding site [chemical binding]; other site
868597005384	Switch I region; other site
868597005385	G2 box; other site
868597005386	G3 box; other site
868597005387	Switch II region; other site
868597005388	G4 box; other site
868597005389	G5 box; other site
868597005390	Nucleoside recognition; Region: Gate; pfam07670
868597005391	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
868597005392	Nucleoside recognition; Region: Gate; pfam07670
868597005393	Domain of unknown function (DUF4304); Region: DUF4304; pfam14137
868597005394	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
868597005395	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597005396	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
868597005397	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
868597005398	DNA binding residues [nucleotide binding]
868597005399	dimer interface [polypeptide binding]; other site
868597005400	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
868597005401	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597005402	NAD(P) binding site [chemical binding]; other site
868597005403	active site
868597005404	dihydrodipicolinate reductase; Provisional; Region: PRK00048
868597005405	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
868597005406	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
868597005407	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
868597005408	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
868597005409	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
868597005410	catalytic site [active]
868597005411	subunit interface [polypeptide binding]; other site
868597005412	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
868597005413	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
868597005414	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
868597005415	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
868597005416	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
868597005417	ATP-grasp domain; Region: ATP-grasp_4; cl17255
868597005418	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
868597005419	IMP binding site; other site
868597005420	dimer interface [polypeptide binding]; other site
868597005421	interdomain contacts; other site
868597005422	partial ornithine binding site; other site
868597005423	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
868597005424	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
868597005425	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
868597005426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
868597005427	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
868597005428	DHH family; Region: DHH; pfam01368
868597005429	DHHA1 domain; Region: DHHA1; pfam02272
868597005430	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
868597005431	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
868597005432	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
868597005433	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
868597005434	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
868597005435	Acyltransferase family; Region: Acyl_transf_3; pfam01757
868597005436	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
868597005437	LytTr DNA-binding domain; Region: LytTR; smart00850
868597005438	peptide chain release factor 2; Provisional; Region: PRK08787
868597005439	This domain is found in peptide chain release factors; Region: PCRF; smart00937
868597005440	RF-1 domain; Region: RF-1; pfam00472
868597005441	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597005442	salt bridge; other site
868597005443	non-specific DNA binding site [nucleotide binding]; other site
868597005444	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
868597005445	sequence-specific DNA binding site [nucleotide binding]; other site
868597005446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
868597005447	Transposase; Region: HTH_Tnp_1; cl17663
868597005448	putative transposase OrfB; Reviewed; Region: PHA02517
868597005449	HTH-like domain; Region: HTH_21; pfam13276
868597005450	Integrase core domain; Region: rve; pfam00665
868597005451	Integrase core domain; Region: rve_3; pfam13683
868597005452	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
868597005453	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
868597005454	NAD(P) binding site [chemical binding]; other site
868597005455	catalytic residues [active]
868597005456	acetolactate synthase; Reviewed; Region: PRK08322
868597005457	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
868597005458	PYR/PP interface [polypeptide binding]; other site
868597005459	dimer interface [polypeptide binding]; other site
868597005460	TPP binding site [chemical binding]; other site
868597005461	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
868597005462	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
868597005463	TPP-binding site [chemical binding]; other site
868597005464	dimer interface [polypeptide binding]; other site
868597005465	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
868597005466	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
868597005467	dimer interface [polypeptide binding]; other site
868597005468	putative anticodon binding site; other site
868597005469	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
868597005470	motif 1; other site
868597005471	active site
868597005472	motif 2; other site
868597005473	motif 3; other site
868597005474	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
868597005475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005476	active site
868597005477	phosphorylation site [posttranslational modification]
868597005478	intermolecular recognition site; other site
868597005479	dimerization interface [polypeptide binding]; other site
868597005480	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
868597005481	Zn2+ binding site [ion binding]; other site
868597005482	Mg2+ binding site [ion binding]; other site
868597005483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597005484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597005485	dimer interface [polypeptide binding]; other site
868597005486	phosphorylation site [posttranslational modification]
868597005487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005488	ATP binding site [chemical binding]; other site
868597005489	Mg2+ binding site [ion binding]; other site
868597005490	G-X-G motif; other site
868597005491	Response regulator receiver domain; Region: Response_reg; pfam00072
868597005492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005493	active site
868597005494	phosphorylation site [posttranslational modification]
868597005495	intermolecular recognition site; other site
868597005496	dimerization interface [polypeptide binding]; other site
868597005497	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
868597005498	putative binding surface; other site
868597005499	active site
868597005500	enoyl-CoA hydratase; Validated; Region: PRK08788
868597005501	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
868597005502	substrate binding site [chemical binding]; other site
868597005503	oxyanion hole (OAH) forming residues; other site
868597005504	trimer interface [polypeptide binding]; other site
868597005505	putative long-chain fatty acyl CoA ligase; Provisional; Region: PRK08751
868597005506	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
868597005507	acyl-activating enzyme (AAE) consensus motif; other site
868597005508	putative AMP binding site [chemical binding]; other site
868597005509	putative active site [active]
868597005510	putative CoA binding site [chemical binding]; other site
868597005511	choline dehydrogenase; Validated; Region: PRK02106
868597005512	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
868597005513	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
868597005514	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
868597005515	tetrameric interface [polypeptide binding]; other site
868597005516	NAD binding site [chemical binding]; other site
868597005517	catalytic residues [active]
868597005518	transcriptional regulator BetI; Validated; Region: PRK00767
868597005519	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597005520	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
868597005521	BCCT family transporter; Region: BCCT; pfam02028
868597005522	aconitate hydratase; Validated; Region: PRK09277
868597005523	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
868597005524	substrate binding site [chemical binding]; other site
868597005525	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
868597005526	ligand binding site [chemical binding]; other site
868597005527	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
868597005528	substrate binding site [chemical binding]; other site
868597005529	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
868597005530	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
868597005531	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
868597005532	putative active site [active]
868597005533	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
868597005534	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
868597005535	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
868597005536	substrate binding site [chemical binding]; other site
868597005537	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
868597005538	substrate binding site [chemical binding]; other site
868597005539	ligand binding site [chemical binding]; other site
868597005540	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
868597005541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005542	active site
868597005543	phosphorylation site [posttranslational modification]
868597005544	intermolecular recognition site; other site
868597005545	dimerization interface [polypeptide binding]; other site
868597005546	CheB methylesterase; Region: CheB_methylest; pfam01339
868597005547	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487
868597005548	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
868597005549	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
868597005550	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
868597005551	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
868597005552	HAMP domain; Region: HAMP; pfam00672
868597005553	dimerization interface [polypeptide binding]; other site
868597005554	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
868597005555	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597005556	dimer interface [polypeptide binding]; other site
868597005557	putative CheW interface [polypeptide binding]; other site
868597005558	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
868597005559	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
868597005560	dimerization interface [polypeptide binding]; other site
868597005561	PAS domain; Region: PAS; smart00091
868597005562	PAS domain; Region: PAS_9; pfam13426
868597005563	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
868597005564	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597005565	dimer interface [polypeptide binding]; other site
868597005566	putative CheW interface [polypeptide binding]; other site
868597005567	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
868597005568	putative CheA interaction surface; other site
868597005569	Flagellar regulator YcgR; Region: YcgR; pfam07317
868597005570	PilZ domain; Region: PilZ; pfam07238
868597005571	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
868597005572	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
868597005573	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
868597005574	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597005575	dimer interface [polypeptide binding]; other site
868597005576	putative CheW interface [polypeptide binding]; other site
868597005577	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
868597005578	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
868597005579	putative binding surface; other site
868597005580	active site
868597005581	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
868597005582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005583	ATP binding site [chemical binding]; other site
868597005584	Mg2+ binding site [ion binding]; other site
868597005585	G-X-G motif; other site
868597005586	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
868597005587	Response regulator receiver domain; Region: Response_reg; pfam00072
868597005588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005589	active site
868597005590	phosphorylation site [posttranslational modification]
868597005591	intermolecular recognition site; other site
868597005592	dimerization interface [polypeptide binding]; other site
868597005593	STAS domain; Region: STAS_2; pfam13466
868597005594	CheW-like domain; Region: CheW; pfam01584
868597005595	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
868597005596	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
868597005597	P-loop; other site
868597005598	Magnesium ion binding site [ion binding]; other site
868597005599	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
868597005600	Magnesium ion binding site [ion binding]; other site
868597005601	flagellar motor protein MotD; Reviewed; Region: PRK09038
868597005602	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
868597005603	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
868597005604	ligand binding site [chemical binding]; other site
868597005605	flagellar motor protein; Reviewed; Region: motC; PRK09109
868597005606	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
868597005607	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
868597005608	putative binding surface; other site
868597005609	active site
868597005610	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
868597005611	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
868597005612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005613	ATP binding site [chemical binding]; other site
868597005614	Mg2+ binding site [ion binding]; other site
868597005615	G-X-G motif; other site
868597005616	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
868597005617	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
868597005618	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
868597005619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005620	active site
868597005621	phosphorylation site [posttranslational modification]
868597005622	intermolecular recognition site; other site
868597005623	dimerization interface [polypeptide binding]; other site
868597005624	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
868597005625	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597005626	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
868597005627	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597005628	DNA binding residues [nucleotide binding]
868597005629	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
868597005630	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
868597005631	P-loop; other site
868597005632	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12727
868597005633	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
868597005634	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
868597005635	FHIPEP family; Region: FHIPEP; pfam00771
868597005636	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
868597005637	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
868597005638	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
868597005639	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
868597005640	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
868597005641	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597005642	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597005643	metal binding site [ion binding]; metal-binding site
868597005644	active site
868597005645	I-site; other site
868597005646	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597005647	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
868597005648	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
868597005649	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
868597005650	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
868597005651	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
868597005652	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
868597005653	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
868597005654	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
868597005655	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
868597005656	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
868597005657	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
868597005658	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
868597005659	Walker A motif/ATP binding site; other site
868597005660	Walker B motif; other site
868597005661	flagellar assembly protein H; Validated; Region: fliH; PRK05687
868597005662	Flagellar assembly protein FliH; Region: FliH; pfam02108
868597005663	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
868597005664	FliG C-terminal domain; Region: FliG_C; pfam01706
868597005665	flagellar MS-ring protein; Reviewed; Region: fliF; PRK12800
868597005666	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
868597005667	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
868597005668	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
868597005669	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
868597005670	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
868597005671	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597005672	Walker A motif; other site
868597005673	ATP binding site [chemical binding]; other site
868597005674	Walker B motif; other site
868597005675	arginine finger; other site
868597005676	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
868597005677	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597005678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005679	active site
868597005680	phosphorylation site [posttranslational modification]
868597005681	intermolecular recognition site; other site
868597005682	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
868597005683	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
868597005684	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
868597005685	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
868597005686	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597005687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005688	active site
868597005689	phosphorylation site [posttranslational modification]
868597005690	intermolecular recognition site; other site
868597005691	dimerization interface [polypeptide binding]; other site
868597005692	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597005693	DNA binding residues [nucleotide binding]
868597005694	flagellar protein FliS; Validated; Region: fliS; PRK05685
868597005695	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
868597005696	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
868597005697	flagellin; Reviewed; Region: PRK08869
868597005698	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
868597005699	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
868597005700	flagellin; Reviewed; Region: PRK08869
868597005701	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
868597005702	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
868597005703	flagellin; Reviewed; Region: PRK08869
868597005704	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
868597005705	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
868597005706	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
868597005707	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
868597005708	flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12714
868597005709	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
868597005710	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
868597005711	flagellar rod assembly protein/muramidase FlgJ; Reviewed; Region: flgJ; PRK12711
868597005712	Rod binding protein; Region: Rod-binding; cl01626
868597005713	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
868597005714	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
868597005715	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
868597005716	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
868597005717	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
868597005718	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
868597005719	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
868597005720	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
868597005721	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
868597005722	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
868597005723	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
868597005724	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
868597005725	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
868597005726	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
868597005727	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634
868597005728	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
868597005729	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12629
868597005730	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
868597005731	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
868597005732	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12620
868597005733	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
868597005734	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
868597005735	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597005736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005737	active site
868597005738	phosphorylation site [posttranslational modification]
868597005739	intermolecular recognition site; other site
868597005740	dimerization interface [polypeptide binding]; other site
868597005741	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
868597005742	Transposase; Region: DEDD_Tnp_IS110; pfam01548
868597005743	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
868597005744	SAF-like; Region: SAF_2; pfam13144
868597005745	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
868597005746	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
868597005747	FlgN protein; Region: FlgN; pfam05130
868597005748	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
868597005749	dimer interface [polypeptide binding]; other site
868597005750	phosphorylation site [posttranslational modification]
868597005751	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005752	ATP binding site [chemical binding]; other site
868597005753	Mg2+ binding site [ion binding]; other site
868597005754	G-X-G motif; other site
868597005755	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597005756	metal binding site [ion binding]; metal-binding site
868597005757	active site
868597005758	I-site; other site
868597005759	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597005760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005761	Response regulator receiver domain; Region: Response_reg; pfam00072
868597005762	active site
868597005763	phosphorylation site [posttranslational modification]
868597005764	intermolecular recognition site; other site
868597005765	dimerization interface [polypeptide binding]; other site
868597005766	PAS domain S-box; Region: sensory_box; TIGR00229
868597005767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597005768	putative active site [active]
868597005769	heme pocket [chemical binding]; other site
868597005770	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597005771	PAS domain; Region: PAS_9; pfam13426
868597005772	putative active site [active]
868597005773	heme pocket [chemical binding]; other site
868597005774	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
868597005775	Histidine kinase; Region: HisKA_3; pfam07730
868597005776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005777	ATP binding site [chemical binding]; other site
868597005778	Mg2+ binding site [ion binding]; other site
868597005779	G-X-G motif; other site
868597005780	PAS fold; Region: PAS_3; pfam08447
868597005781	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597005782	heme pocket [chemical binding]; other site
868597005783	putative active site [active]
868597005784	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
868597005785	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597005786	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597005787	metal binding site [ion binding]; metal-binding site
868597005788	active site
868597005789	I-site; other site
868597005790	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597005791	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
868597005792	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597005793	dimer interface [polypeptide binding]; other site
868597005794	putative CheW interface [polypeptide binding]; other site
868597005795	putative lysogenization regulator; Reviewed; Region: PRK00218
868597005796	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
868597005797	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
868597005798	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
868597005799	nudix motif; other site
868597005800	Uncharacterized conserved protein [Function unknown]; Region: COG2127
868597005801	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
868597005802	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
868597005803	Clp amino terminal domain; Region: Clp_N; pfam02861
868597005804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597005805	Walker A motif; other site
868597005806	ATP binding site [chemical binding]; other site
868597005807	Walker B motif; other site
868597005808	arginine finger; other site
868597005809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597005810	Walker A motif; other site
868597005811	ATP binding site [chemical binding]; other site
868597005812	Walker B motif; other site
868597005813	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
868597005814	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
868597005815	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
868597005816	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597005817	sequence-specific DNA binding site [nucleotide binding]; other site
868597005818	salt bridge; other site
868597005819	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
868597005820	rRNA binding site [nucleotide binding]; other site
868597005821	predicted 30S ribosome binding site; other site
868597005822	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
868597005823	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
868597005824	Protein of unknown function, DUF482; Region: DUF482; pfam04339
868597005825	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
868597005826	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
868597005827	active site
868597005828	thioredoxin reductase; Provisional; Region: PRK10262
868597005829	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
868597005830	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
868597005831	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
868597005832	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
868597005833	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
868597005834	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
868597005835	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
868597005836	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
868597005837	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
868597005838	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
868597005839	recombination factor protein RarA; Reviewed; Region: PRK13342
868597005840	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597005841	Walker A motif; other site
868597005842	ATP binding site [chemical binding]; other site
868597005843	Walker B motif; other site
868597005844	arginine finger; other site
868597005845	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
868597005846	Protein of unknown function (DUF805); Region: DUF805; pfam05656
868597005847	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
868597005848	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
868597005849	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
868597005850	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
868597005851	intersubunit interface [polypeptide binding]; other site
868597005852	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
868597005853	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
868597005854	ABC-ATPase subunit  interface; other site
868597005855	dimer interface [polypeptide binding]; other site
868597005856	putative PBP binding regions; other site
868597005857	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
868597005858	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
868597005859	Walker A/P-loop; other site
868597005860	ATP binding site [chemical binding]; other site
868597005861	Q-loop/lid; other site
868597005862	ABC transporter signature motif; other site
868597005863	Walker B; other site
868597005864	D-loop; other site
868597005865	H-loop/switch region; other site
868597005866	elongation factor G; Reviewed; Region: PRK12739
868597005867	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
868597005868	G1 box; other site
868597005869	GTP/Mg2+ binding site [chemical binding]; other site
868597005870	G2 box; other site
868597005871	Switch I region; other site
868597005872	G3 box; other site
868597005873	Switch II region; other site
868597005874	G4 box; other site
868597005875	G5 box; other site
868597005876	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
868597005877	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
868597005878	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
868597005879	SapC; Region: SapC; pfam07277
868597005880	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
868597005881	dimer interface [polypeptide binding]; other site
868597005882	phosphorylation site [posttranslational modification]
868597005883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005884	ATP binding site [chemical binding]; other site
868597005885	Mg2+ binding site [ion binding]; other site
868597005886	G-X-G motif; other site
868597005887	Response regulator receiver domain; Region: Response_reg; pfam00072
868597005888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005889	active site
868597005890	phosphorylation site [posttranslational modification]
868597005891	intermolecular recognition site; other site
868597005892	dimerization interface [polypeptide binding]; other site
868597005893	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597005894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005895	active site
868597005896	phosphorylation site [posttranslational modification]
868597005897	intermolecular recognition site; other site
868597005898	dimerization interface [polypeptide binding]; other site
868597005899	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597005900	DNA binding residues [nucleotide binding]
868597005901	dimerization interface [polypeptide binding]; other site
868597005902	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
868597005903	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
868597005904	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
868597005905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597005906	S-adenosylmethionine binding site [chemical binding]; other site
868597005907	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
868597005908	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
868597005909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597005910	S-adenosylmethionine binding site [chemical binding]; other site
868597005911	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
868597005912	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
868597005913	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
868597005914	Fatty acid desaturase; Region: FA_desaturase; pfam00487
868597005915	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
868597005916	Di-iron ligands [ion binding]; other site
868597005917	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
868597005918	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
868597005919	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597005920	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597005921	DNA binding residues [nucleotide binding]
868597005922	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
868597005923	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
868597005924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597005925	NAD(P) binding site [chemical binding]; other site
868597005926	active site
868597005927	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597005928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005929	active site
868597005930	phosphorylation site [posttranslational modification]
868597005931	intermolecular recognition site; other site
868597005932	dimerization interface [polypeptide binding]; other site
868597005933	PAS fold; Region: PAS_4; pfam08448
868597005934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597005935	putative active site [active]
868597005936	heme pocket [chemical binding]; other site
868597005937	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
868597005938	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597005939	dimer interface [polypeptide binding]; other site
868597005940	phosphorylation site [posttranslational modification]
868597005941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005942	ATP binding site [chemical binding]; other site
868597005943	Mg2+ binding site [ion binding]; other site
868597005944	G-X-G motif; other site
868597005945	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597005946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005947	active site
868597005948	phosphorylation site [posttranslational modification]
868597005949	intermolecular recognition site; other site
868597005950	dimerization interface [polypeptide binding]; other site
868597005951	Response regulator receiver domain; Region: Response_reg; pfam00072
868597005952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597005953	active site
868597005954	phosphorylation site [posttranslational modification]
868597005955	intermolecular recognition site; other site
868597005956	dimerization interface [polypeptide binding]; other site
868597005957	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
868597005958	GAF domain; Region: GAF; pfam01590
868597005959	Phytochrome region; Region: PHY; pfam00360
868597005960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597005961	dimer interface [polypeptide binding]; other site
868597005962	phosphorylation site [posttranslational modification]
868597005963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597005964	ATP binding site [chemical binding]; other site
868597005965	Mg2+ binding site [ion binding]; other site
868597005966	G-X-G motif; other site
868597005967	TspO/MBR family; Region: TspO_MBR; pfam03073
868597005968	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
868597005969	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597005970	Coenzyme A binding pocket [chemical binding]; other site
868597005971	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597005972	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597005973	Helix-turn-helix domain; Region: HTH_18; pfam12833
868597005974	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
868597005975	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597005976	putative DNA binding site [nucleotide binding]; other site
868597005977	dimerization interface [polypeptide binding]; other site
868597005978	putative Zn2+ binding site [ion binding]; other site
868597005979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597005980	AAA domain; Region: AAA_21; pfam13304
868597005981	Walker A/P-loop; other site
868597005982	ATP binding site [chemical binding]; other site
868597005983	Q-loop/lid; other site
868597005984	ABC transporter signature motif; other site
868597005985	Walker B; other site
868597005986	D-loop; other site
868597005987	H-loop/switch region; other site
868597005988	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
868597005989	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
868597005990	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
868597005991	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
868597005992	Ligand binding site; other site
868597005993	metal-binding site
868597005994	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
868597005995	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
868597005996	XdhC Rossmann domain; Region: XdhC_C; pfam13478
868597005997	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
868597005998	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
868597005999	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
868597006000	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
868597006001	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
868597006002	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
868597006003	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
868597006004	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
868597006005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
868597006006	SnoaL-like domain; Region: SnoaL_2; pfam12680
868597006007	putative transcriptional regulator; Provisional; Region: PRK11640
868597006008	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597006009	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597006010	Walker A/P-loop; other site
868597006011	ATP binding site [chemical binding]; other site
868597006012	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
868597006013	Q-loop/lid; other site
868597006014	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
868597006015	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597006016	Walker A/P-loop; other site
868597006017	ATP binding site [chemical binding]; other site
868597006018	Q-loop/lid; other site
868597006019	ABC transporter signature motif; other site
868597006020	Walker B; other site
868597006021	D-loop; other site
868597006022	H-loop/switch region; other site
868597006023	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
868597006024	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
868597006025	Helix-turn-helix domain; Region: HTH_18; pfam12833
868597006026	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597006027	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597006028	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597006029	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
868597006030	Protein export membrane protein; Region: SecD_SecF; cl14618
868597006031	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
868597006032	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597006033	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597006034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597006035	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
868597006036	NADH dehydrogenase subunit D; Validated; Region: PRK06075
868597006037	Transcriptional regulators [Transcription]; Region: PurR; COG1609
868597006038	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
868597006039	DNA binding site [nucleotide binding]
868597006040	domain linker motif; other site
868597006041	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
868597006042	putative dimerization interface [polypeptide binding]; other site
868597006043	putative ligand binding site [chemical binding]; other site
868597006044	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
868597006045	active site
868597006046	phosphorylation site [posttranslational modification]
868597006047	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
868597006048	dimerization domain swap beta strand [polypeptide binding]; other site
868597006049	regulatory protein interface [polypeptide binding]; other site
868597006050	active site
868597006051	regulatory phosphorylation site [posttranslational modification]; other site
868597006052	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
868597006053	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
868597006054	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
868597006055	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
868597006056	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
868597006057	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
868597006058	putative substrate binding site [chemical binding]; other site
868597006059	putative ATP binding site [chemical binding]; other site
868597006060	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
868597006061	active site
868597006062	P-loop; other site
868597006063	phosphorylation site [posttranslational modification]
868597006064	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
868597006065	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
868597006066	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
868597006067	NmrA-like family; Region: NmrA; pfam05368
868597006068	NAD(P) binding site [chemical binding]; other site
868597006069	active site lysine
868597006070	Predicted transcriptional regulators [Transcription]; Region: COG1733
868597006071	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
868597006072	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
868597006073	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
868597006074	transmembrane helices; other site
868597006075	Protein of unknown function DUF72; Region: DUF72; pfam01904
868597006076	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597006077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006078	active site
868597006079	phosphorylation site [posttranslational modification]
868597006080	intermolecular recognition site; other site
868597006081	dimerization interface [polypeptide binding]; other site
868597006082	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
868597006083	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
868597006084	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
868597006085	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
868597006086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597006087	dimer interface [polypeptide binding]; other site
868597006088	conserved gate region; other site
868597006089	putative PBP binding loops; other site
868597006090	ABC-ATPase subunit interface; other site
868597006091	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
868597006092	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
868597006093	Walker A/P-loop; other site
868597006094	ATP binding site [chemical binding]; other site
868597006095	Q-loop/lid; other site
868597006096	ABC transporter signature motif; other site
868597006097	Walker B; other site
868597006098	D-loop; other site
868597006099	H-loop/switch region; other site
868597006100	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
868597006101	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
868597006102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
868597006103	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597006104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597006105	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
868597006106	putative dimerization interface [polypeptide binding]; other site
868597006107	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
868597006108	FAD binding site [chemical binding]; other site
868597006109	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
868597006110	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597006111	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
868597006112	putative dimerization interface [polypeptide binding]; other site
868597006113	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597006114	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
868597006115	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
868597006116	methionine synthase; Provisional; Region: PRK01207
868597006117	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
868597006118	substrate binding site [chemical binding]; other site
868597006119	THF binding site; other site
868597006120	zinc-binding site [ion binding]; other site
868597006121	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
868597006122	active site
868597006123	substrate binding sites [chemical binding]; other site
868597006124	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
868597006125	nudix motif; other site
868597006126	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
868597006127	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597006128	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
868597006129	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
868597006130	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
868597006131	active site
868597006132	substrate binding site [chemical binding]; other site
868597006133	Mg2+ binding site [ion binding]; other site
868597006134	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
868597006135	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597006136	active site
868597006137	motif I; other site
868597006138	motif II; other site
868597006139	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597006140	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
868597006141	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597006142	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597006143	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
868597006144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597006145	Walker A motif; other site
868597006146	ATP binding site [chemical binding]; other site
868597006147	Walker B motif; other site
868597006148	arginine finger; other site
868597006149	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
868597006150	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
868597006151	putative active site [active]
868597006152	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
868597006153	Killing trait; Region: RebB; pfam11747
868597006154	Killing trait; Region: RebB; pfam11747
868597006155	Killing trait; Region: RebB; pfam11747
868597006156	Killing trait; Region: RebB; pfam11747
868597006157	Killing trait; Region: RebB; pfam11747
868597006158	Killing trait; Region: RebB; pfam11747
868597006159	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
868597006160	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597006161	Walker A motif; other site
868597006162	ATP binding site [chemical binding]; other site
868597006163	Walker B motif; other site
868597006164	arginine finger; other site
868597006165	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597006166	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597006167	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597006168	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
868597006169	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
868597006170	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
868597006171	Short C-terminal domain; Region: SHOCT; pfam09851
868597006172	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
868597006173	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
868597006174	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
868597006175	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
868597006176	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
868597006177	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597006178	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597006179	N-terminal plug; other site
868597006180	ligand-binding site [chemical binding]; other site
868597006181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597006182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597006183	Uncharacterized conserved protein [Function unknown]; Region: COG1479
868597006184	Protein of unknown function DUF262; Region: DUF262; pfam03235
868597006185	Protein of unknown function DUF262; Region: DUF262; pfam03235
868597006186	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
868597006187	Protease inhibitor Inh; Region: Inh; pfam02974
868597006188	Cation efflux family; Region: Cation_efflux; pfam01545
868597006189	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
868597006190	active site
868597006191	DNA binding site [nucleotide binding]
868597006192	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
868597006193	GAF domain; Region: GAF; pfam01590
868597006194	PAS domain S-box; Region: sensory_box; TIGR00229
868597006195	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597006196	putative active site [active]
868597006197	heme pocket [chemical binding]; other site
868597006198	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597006199	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597006200	metal binding site [ion binding]; metal-binding site
868597006201	active site
868597006202	I-site; other site
868597006203	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
868597006204	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
868597006205	Walker A/P-loop; other site
868597006206	ATP binding site [chemical binding]; other site
868597006207	Q-loop/lid; other site
868597006208	ABC transporter signature motif; other site
868597006209	Walker B; other site
868597006210	D-loop; other site
868597006211	H-loop/switch region; other site
868597006212	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597006213	FtsX-like permease family; Region: FtsX; pfam02687
868597006214	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597006215	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597006216	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597006217	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597006218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006219	active site
868597006220	phosphorylation site [posttranslational modification]
868597006221	intermolecular recognition site; other site
868597006222	dimerization interface [polypeptide binding]; other site
868597006223	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597006224	DNA binding site [nucleotide binding]
868597006225	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597006226	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
868597006227	dimerization interface [polypeptide binding]; other site
868597006228	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597006229	dimer interface [polypeptide binding]; other site
868597006230	phosphorylation site [posttranslational modification]
868597006231	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597006232	ATP binding site [chemical binding]; other site
868597006233	Mg2+ binding site [ion binding]; other site
868597006234	G-X-G motif; other site
868597006235	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
868597006236	tetracycline repressor protein TetR; Provisional; Region: PRK13756
868597006237	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
868597006238	FAD binding pocket [chemical binding]; other site
868597006239	FAD binding motif [chemical binding]; other site
868597006240	phosphate binding motif [ion binding]; other site
868597006241	NAD binding pocket [chemical binding]; other site
868597006242	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
868597006243	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597006244	N-terminal plug; other site
868597006245	ligand-binding site [chemical binding]; other site
868597006246	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
868597006247	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
868597006248	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
868597006249	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
868597006250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
868597006251	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
868597006252	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597006253	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
868597006254	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597006255	N-terminal plug; other site
868597006256	ligand-binding site [chemical binding]; other site
868597006257	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
868597006258	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597006259	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
868597006260	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
868597006261	putative active site [active]
868597006262	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
868597006263	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
868597006264	Walker A/P-loop; other site
868597006265	ATP binding site [chemical binding]; other site
868597006266	Q-loop/lid; other site
868597006267	ABC transporter signature motif; other site
868597006268	Walker B; other site
868597006269	D-loop; other site
868597006270	H-loop/switch region; other site
868597006271	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
868597006272	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
868597006273	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
868597006274	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
868597006275	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
868597006276	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
868597006277	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
868597006278	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
868597006279	PapC N-terminal domain; Region: PapC_N; pfam13954
868597006280	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
868597006281	PapC C-terminal domain; Region: PapC_C; pfam13953
868597006282	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
868597006283	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
868597006284	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
868597006285	Fimbrial protein; Region: Fimbrial; pfam00419
868597006286	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
868597006287	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597006288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006289	active site
868597006290	phosphorylation site [posttranslational modification]
868597006291	intermolecular recognition site; other site
868597006292	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597006293	DNA binding residues [nucleotide binding]
868597006294	dimerization interface [polypeptide binding]; other site
868597006295	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597006296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006297	active site
868597006298	phosphorylation site [posttranslational modification]
868597006299	intermolecular recognition site; other site
868597006300	dimerization interface [polypeptide binding]; other site
868597006301	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597006302	DNA binding residues [nucleotide binding]
868597006303	dimerization interface [polypeptide binding]; other site
868597006304	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
868597006305	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597006306	dimer interface [polypeptide binding]; other site
868597006307	phosphorylation site [posttranslational modification]
868597006308	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597006309	ATP binding site [chemical binding]; other site
868597006310	Mg2+ binding site [ion binding]; other site
868597006311	G-X-G motif; other site
868597006312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006313	active site
868597006314	phosphorylation site [posttranslational modification]
868597006315	intermolecular recognition site; other site
868597006316	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
868597006317	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597006318	dimer interface [polypeptide binding]; other site
868597006319	phosphorylation site [posttranslational modification]
868597006320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597006321	ATP binding site [chemical binding]; other site
868597006322	Mg2+ binding site [ion binding]; other site
868597006323	G-X-G motif; other site
868597006324	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
868597006325	conjugal transfer protein TrbP; Provisional; Region: PRK13882
868597006326	TraX protein; Region: TraX; pfam05857
868597006327	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
868597006328	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
868597006329	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
868597006330	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
868597006331	dimerization interface [polypeptide binding]; other site
868597006332	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597006333	dimer interface [polypeptide binding]; other site
868597006334	phosphorylation site [posttranslational modification]
868597006335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597006336	ATP binding site [chemical binding]; other site
868597006337	Mg2+ binding site [ion binding]; other site
868597006338	G-X-G motif; other site
868597006339	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
868597006340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006341	active site
868597006342	phosphorylation site [posttranslational modification]
868597006343	intermolecular recognition site; other site
868597006344	dimerization interface [polypeptide binding]; other site
868597006345	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597006346	DNA binding site [nucleotide binding]
868597006347	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
868597006348	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597006349	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
868597006350	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597006351	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
868597006352	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
868597006353	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
868597006354	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
868597006355	Soluble P-type ATPase [General function prediction only]; Region: COG4087
868597006356	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
868597006357	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
868597006358	MgtC family; Region: MgtC; pfam02308
868597006359	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597006360	dimer interface [polypeptide binding]; other site
868597006361	phosphorylation site [posttranslational modification]
868597006362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597006363	ATP binding site [chemical binding]; other site
868597006364	Mg2+ binding site [ion binding]; other site
868597006365	G-X-G motif; other site
868597006366	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
868597006367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006368	active site
868597006369	phosphorylation site [posttranslational modification]
868597006370	intermolecular recognition site; other site
868597006371	dimerization interface [polypeptide binding]; other site
868597006372	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597006373	DNA binding residues [nucleotide binding]
868597006374	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
868597006375	Predicted membrane protein [Function unknown]; Region: COG2510
868597006376	Calcium binding and coiled-coil domain (CALCOCO1) like; Region: CALCOCO1; pfam07888
868597006377	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
868597006378	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
868597006379	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597006380	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
868597006381	DNA binding residues [nucleotide binding]
868597006382	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
868597006383	FecR protein; Region: FecR; pfam04773
868597006384	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597006385	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006386	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
868597006387	Predicted metal-binding protein [General function prediction only]; Region: COG3019
868597006388	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
868597006389	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
868597006390	putative molybdopterin cofactor binding site [chemical binding]; other site
868597006391	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
868597006392	putative molybdopterin cofactor binding site; other site
868597006393	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
868597006394	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
868597006395	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
868597006396	Cupin; Region: Cupin_6; pfam12852
868597006397	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597006398	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597006399	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597006400	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
868597006401	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597006402	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
868597006403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597006404	putative substrate translocation pore; other site
868597006405	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
868597006406	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
868597006407	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597006408	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
868597006409	FtsX-like permease family; Region: FtsX; pfam02687
868597006410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597006411	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
868597006412	Walker A/P-loop; other site
868597006413	ATP binding site [chemical binding]; other site
868597006414	Q-loop/lid; other site
868597006415	ABC transporter signature motif; other site
868597006416	Walker B; other site
868597006417	D-loop; other site
868597006418	H-loop/switch region; other site
868597006419	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
868597006420	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597006421	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597006422	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
868597006423	putative effector binding pocket; other site
868597006424	dimerization interface [polypeptide binding]; other site
868597006425	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
868597006426	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
868597006427	active site
868597006428	catalytic tetrad [active]
868597006429	CopC domain; Region: CopC; pfam04234
868597006430	Copper resistance protein D; Region: CopD; cl00563
868597006431	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
868597006432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006433	active site
868597006434	phosphorylation site [posttranslational modification]
868597006435	intermolecular recognition site; other site
868597006436	dimerization interface [polypeptide binding]; other site
868597006437	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597006438	DNA binding site [nucleotide binding]
868597006439	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
868597006440	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597006441	dimer interface [polypeptide binding]; other site
868597006442	phosphorylation site [posttranslational modification]
868597006443	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597006444	ATP binding site [chemical binding]; other site
868597006445	Mg2+ binding site [ion binding]; other site
868597006446	G-X-G motif; other site
868597006447	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597006448	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597006449	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
868597006450	putative effector binding pocket; other site
868597006451	putative dimerization interface [polypeptide binding]; other site
868597006452	short chain dehydrogenase; Provisional; Region: PRK12937
868597006453	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
868597006454	NADP binding site [chemical binding]; other site
868597006455	homodimer interface [polypeptide binding]; other site
868597006456	active site
868597006457	substrate binding site [chemical binding]; other site
868597006458	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
868597006459	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597006460	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597006461	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597006462	Outer membrane efflux protein; Region: OEP; pfam02321
868597006463	Outer membrane efflux protein; Region: OEP; pfam02321
868597006464	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
868597006465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006466	active site
868597006467	phosphorylation site [posttranslational modification]
868597006468	intermolecular recognition site; other site
868597006469	dimerization interface [polypeptide binding]; other site
868597006470	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597006471	DNA binding site [nucleotide binding]
868597006472	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
868597006473	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597006474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597006475	dimer interface [polypeptide binding]; other site
868597006476	phosphorylation site [posttranslational modification]
868597006477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597006478	ATP binding site [chemical binding]; other site
868597006479	Mg2+ binding site [ion binding]; other site
868597006480	G-X-G motif; other site
868597006481	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
868597006482	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
868597006483	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597006484	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
868597006485	nudix motif; other site
868597006486	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
868597006487	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
868597006488	catalytic residues [active]
868597006489	Protein required for attachment to host cells; Region: Host_attach; pfam10116
868597006490	proline/glycine betaine transporter; Provisional; Region: PRK10642
868597006491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597006492	putative substrate translocation pore; other site
868597006493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
868597006494	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
868597006495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597006496	PAS domain; Region: PAS_9; pfam13426
868597006497	putative active site [active]
868597006498	heme pocket [chemical binding]; other site
868597006499	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
868597006500	HWE histidine kinase; Region: HWE_HK; smart00911
868597006501	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597006502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006503	active site
868597006504	phosphorylation site [posttranslational modification]
868597006505	intermolecular recognition site; other site
868597006506	dimerization interface [polypeptide binding]; other site
868597006507	Tetratricopeptide repeat; Region: TPR_16; pfam13432
868597006508	Protein of unknown function (DUF560); Region: DUF560; pfam04575
868597006509	Secretin and TonB N terminus short domain; Region: STN; smart00965
868597006510	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006511	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006512	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
868597006513	FecR protein; Region: FecR; pfam04773
868597006514	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
868597006515	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
868597006516	DNA binding residues [nucleotide binding]
868597006517	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
868597006518	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597006519	N-terminal plug; other site
868597006520	ligand-binding site [chemical binding]; other site
868597006521	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
868597006522	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
868597006523	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
868597006524	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
868597006525	Uncharacterized conserved protein (DUF2149); Region: DUF2149; cl01960
868597006526	LysR family transcriptional regulator; Provisional; Region: PRK14997
868597006527	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597006528	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
868597006529	putative effector binding pocket; other site
868597006530	putative dimerization interface [polypeptide binding]; other site
868597006531	Pirin-related protein [General function prediction only]; Region: COG1741
868597006532	Pirin; Region: Pirin; pfam02678
868597006533	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
868597006534	Isochorismatase family; Region: Isochorismatase; pfam00857
868597006535	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
868597006536	catalytic triad [active]
868597006537	dimer interface [polypeptide binding]; other site
868597006538	conserved cis-peptide bond; other site
868597006539	Isochorismatase family; Region: Isochorismatase; pfam00857
868597006540	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
868597006541	catalytic triad [active]
868597006542	dimer interface [polypeptide binding]; other site
868597006543	conserved cis-peptide bond; other site
868597006544	OsmC-like protein; Region: OsmC; pfam02566
868597006545	TonB C terminal; Region: TonB_2; pfam13103
868597006546	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
868597006547	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
868597006548	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
868597006549	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
868597006550	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
868597006551	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
868597006552	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
868597006553	Surface antigen; Region: Bac_surface_Ag; pfam01103
868597006554	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
868597006555	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
868597006556	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
868597006557	Type II transport protein GspH; Region: GspH; pfam12019
868597006558	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
868597006559	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
868597006560	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
868597006561	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
868597006562	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
868597006563	PBP superfamily domain; Region: PBP_like_2; cl17296
868597006564	type II secretion system protein F; Region: GspF; TIGR02120
868597006565	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597006566	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597006567	type II secretion system protein E; Region: type_II_gspE; TIGR02533
868597006568	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
868597006569	Walker A motif; other site
868597006570	ATP binding site [chemical binding]; other site
868597006571	Walker B motif; other site
868597006572	type II secretion system protein D; Region: type_II_gspD; TIGR02517
868597006573	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
868597006574	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
868597006575	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
868597006576	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
868597006577	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
868597006578	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
868597006579	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
868597006580	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
868597006581	FecR protein; Region: FecR; pfam04773
868597006582	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
868597006583	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597006584	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
868597006585	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
868597006586	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597006587	putative DNA binding site [nucleotide binding]; other site
868597006588	putative Zn2+ binding site [ion binding]; other site
868597006589	AsnC family; Region: AsnC_trans_reg; pfam01037
868597006590	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
868597006591	Predicted membrane protein [Function unknown]; Region: COG4541
868597006592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597006593	PAS domain; Region: PAS_9; pfam13426
868597006594	putative active site [active]
868597006595	heme pocket [chemical binding]; other site
868597006596	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
868597006597	Flavodoxin; Region: Flavodoxin_1; pfam00258
868597006598	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
868597006599	FAD binding pocket [chemical binding]; other site
868597006600	conserved FAD binding motif [chemical binding]; other site
868597006601	phosphate binding motif [ion binding]; other site
868597006602	beta-alpha-beta structure motif; other site
868597006603	NAD binding pocket [chemical binding]; other site
868597006604	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
868597006605	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
868597006606	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
868597006607	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
868597006608	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597006609	N-terminal plug; other site
868597006610	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
868597006611	ligand-binding site [chemical binding]; other site
868597006612	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
868597006613	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
868597006614	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
868597006615	intersubunit interface [polypeptide binding]; other site
868597006616	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
868597006617	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
868597006618	putative PBP binding regions; other site
868597006619	ABC-ATPase subunit  interface; other site
868597006620	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
868597006621	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
868597006622	Walker A/P-loop; other site
868597006623	ATP binding site [chemical binding]; other site
868597006624	Q-loop/lid; other site
868597006625	ABC transporter signature motif; other site
868597006626	Walker B; other site
868597006627	D-loop; other site
868597006628	H-loop/switch region; other site
868597006629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597006630	Methyltransferase domain; Region: Methyltransf_31; pfam13847
868597006631	S-adenosylmethionine binding site [chemical binding]; other site
868597006632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597006633	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
868597006634	Walker A/P-loop; other site
868597006635	ATP binding site [chemical binding]; other site
868597006636	Q-loop/lid; other site
868597006637	ABC transporter signature motif; other site
868597006638	Walker B; other site
868597006639	D-loop; other site
868597006640	H-loop/switch region; other site
868597006641	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
868597006642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597006643	dimer interface [polypeptide binding]; other site
868597006644	conserved gate region; other site
868597006645	putative PBP binding loops; other site
868597006646	ABC-ATPase subunit interface; other site
868597006647	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
868597006648	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
868597006649	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
868597006650	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
868597006651	ligand binding site [chemical binding]; other site
868597006652	flexible hinge region; other site
868597006653	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
868597006654	putative switch regulator; other site
868597006655	non-specific DNA interactions [nucleotide binding]; other site
868597006656	DNA binding site [nucleotide binding]
868597006657	sequence specific DNA binding site [nucleotide binding]; other site
868597006658	putative cAMP binding site [chemical binding]; other site
868597006659	coproporphyrinogen III oxidase; Provisional; Region: PRK13347
868597006660	HemN C-terminal domain; Region: HemN_C; pfam06969
868597006661	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
868597006662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597006663	putative substrate translocation pore; other site
868597006664	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
868597006665	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
868597006666	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
868597006667	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
868597006668	4Fe-4S binding domain; Region: Fer4_6; pfam12837
868597006669	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
868597006670	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
868597006671	[4Fe-4S] binding site [ion binding]; other site
868597006672	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
868597006673	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
868597006674	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
868597006675	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
868597006676	molybdopterin cofactor binding site; other site
868597006677	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
868597006678	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
868597006679	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
868597006680	GTP binding site; other site
868597006681	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
868597006682	MoaE homodimer interface [polypeptide binding]; other site
868597006683	MoaD interaction [polypeptide binding]; other site
868597006684	active site residues [active]
868597006685	Ubiquitin-like proteins; Region: UBQ; cl00155
868597006686	charged pocket; other site
868597006687	hydrophobic patch; other site
868597006688	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
868597006689	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
868597006690	dimer interface [polypeptide binding]; other site
868597006691	putative functional site; other site
868597006692	putative MPT binding site; other site
868597006693	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
868597006694	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
868597006695	trimer interface [polypeptide binding]; other site
868597006696	dimer interface [polypeptide binding]; other site
868597006697	putative active site [active]
868597006698	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
868597006699	MPT binding site; other site
868597006700	trimer interface [polypeptide binding]; other site
868597006701	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
868597006702	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597006703	FeS/SAM binding site; other site
868597006704	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
868597006705	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
868597006706	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
868597006707	DNA binding residues [nucleotide binding]
868597006708	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
868597006709	dimer interface [polypeptide binding]; other site
868597006710	putative metal binding site [ion binding]; other site
868597006711	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
868597006712	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597006713	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597006714	dimerization interface [polypeptide binding]; other site
868597006715	putative DNA binding site [nucleotide binding]; other site
868597006716	putative Zn2+ binding site [ion binding]; other site
868597006717	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
868597006718	Low molecular weight phosphatase family; Region: LMWPc; cl00105
868597006719	active site
868597006720	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
868597006721	Sodium Bile acid symporter family; Region: SBF; cl17470
868597006722	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
868597006723	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
868597006724	SnoaL-like domain; Region: SnoaL_3; pfam13474
868597006725	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
868597006726	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
868597006727	putative active site [active]
868597006728	Zn binding site [ion binding]; other site
868597006729	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
868597006730	hypothetical protein; Provisional; Region: PRK09040
868597006731	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
868597006732	ligand binding site [chemical binding]; other site
868597006733	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
868597006734	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597006735	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006736	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
868597006737	Transposase IS200 like; Region: Y1_Tnp; pfam01797
868597006738	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
868597006739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597006740	NAD(P) binding site [chemical binding]; other site
868597006741	active site
868597006742	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
868597006743	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
868597006744	acyl-activating enzyme (AAE) consensus motif; other site
868597006745	AMP binding site [chemical binding]; other site
868597006746	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
868597006747	Phosphopantetheine attachment site; Region: PP-binding; cl09936
868597006748	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
868597006749	Isochorismatase family; Region: Isochorismatase; pfam00857
868597006750	catalytic triad [active]
868597006751	conserved cis-peptide bond; other site
868597006752	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
868597006753	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
868597006754	acyl-activating enzyme (AAE) consensus motif; other site
868597006755	active site
868597006756	AMP binding site [chemical binding]; other site
868597006757	substrate binding site [chemical binding]; other site
868597006758	isochorismate synthase DhbC; Validated; Region: PRK06923
868597006759	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
868597006760	Major Facilitator Superfamily; Region: MFS_1; pfam07690
868597006761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597006762	putative substrate translocation pore; other site
868597006763	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
868597006764	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
868597006765	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
868597006766	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
868597006767	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
868597006768	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597006769	Coenzyme A binding pocket [chemical binding]; other site
868597006770	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
868597006771	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
868597006772	catalytic residues [active]
868597006773	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
868597006774	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
868597006775	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
868597006776	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
868597006777	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
868597006778	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
868597006779	putative di-iron ligands [ion binding]; other site
868597006780	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
868597006781	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
868597006782	FAD binding pocket [chemical binding]; other site
868597006783	FAD binding motif [chemical binding]; other site
868597006784	phosphate binding motif [ion binding]; other site
868597006785	beta-alpha-beta structure motif; other site
868597006786	NAD binding pocket [chemical binding]; other site
868597006787	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
868597006788	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
868597006789	catalytic loop [active]
868597006790	iron binding site [ion binding]; other site
868597006791	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
868597006792	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597006793	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
868597006794	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597006795	N-terminal plug; other site
868597006796	ligand-binding site [chemical binding]; other site
868597006797	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
868597006798	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
868597006799	manganese transport regulator MntR; Provisional; Region: PRK11050
868597006800	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
868597006801	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
868597006802	manganese transport protein MntH; Reviewed; Region: PRK00701
868597006803	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
868597006804	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
868597006805	catalytic residues [active]
868597006806	flavodoxin; Provisional; Region: PRK09271
868597006807	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
868597006808	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
868597006809	dimer interface [polypeptide binding]; other site
868597006810	putative radical transfer pathway; other site
868597006811	diiron center [ion binding]; other site
868597006812	tyrosyl radical; other site
868597006813	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
868597006814	Class I ribonucleotide reductase; Region: RNR_I; cd01679
868597006815	active site
868597006816	dimer interface [polypeptide binding]; other site
868597006817	catalytic residues [active]
868597006818	effector binding site; other site
868597006819	R2 peptide binding site; other site
868597006820	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
868597006821	2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
868597006822	putative NAD(P) binding site [chemical binding]; other site
868597006823	putative dimer interface [polypeptide binding]; other site
868597006824	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006825	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006826	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597006827	BCCT family transporter; Region: BCCT; cl00569
868597006828	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
868597006829	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597006830	RNA polymerase sigma factor; Provisional; Region: PRK12528
868597006831	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597006832	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597006833	DNA binding residues [nucleotide binding]
868597006834	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
868597006835	FecR protein; Region: FecR; pfam04773
868597006836	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006837	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006838	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
868597006839	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
868597006840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597006841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597006842	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
868597006843	dimerization interface [polypeptide binding]; other site
868597006844	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
868597006845	putative active site [active]
868597006846	Zn binding site [ion binding]; other site
868597006847	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
868597006848	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597006849	N-terminal plug; other site
868597006850	ligand-binding site [chemical binding]; other site
868597006851	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
868597006852	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
868597006853	Cl- selectivity filter; other site
868597006854	Cl- binding residues [ion binding]; other site
868597006855	pore gating glutamate residue; other site
868597006856	dimer interface [polypeptide binding]; other site
868597006857	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
868597006858	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
868597006859	MgtC family; Region: MgtC; pfam02308
868597006860	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
868597006861	DNA binding residues [nucleotide binding]
868597006862	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
868597006863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597006864	S-adenosylmethionine binding site [chemical binding]; other site
868597006865	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
868597006866	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
868597006867	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
868597006868	ligand binding site [chemical binding]; other site
868597006869	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
868597006870	Haemagglutinin; Region: HIM; pfam05662
868597006871	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
868597006872	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
868597006873	YadA-like C-terminal region; Region: YadA; pfam03895
868597006874	Helix-turn-helix domain; Region: HTH_18; pfam12833
868597006875	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597006876	Flp/Fap pilin component; Region: Flp_Fap; cl01585
868597006877	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
868597006878	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
868597006879	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
868597006880	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
868597006881	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
868597006882	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
868597006883	AAA domain; Region: AAA_31; pfam13614
868597006884	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
868597006885	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
868597006886	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
868597006887	ATP binding site [chemical binding]; other site
868597006888	Walker A motif; other site
868597006889	hexamer interface [polypeptide binding]; other site
868597006890	Walker B motif; other site
868597006891	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
868597006892	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597006893	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597006894	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
868597006895	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597006896	TPR motif; other site
868597006897	binding surface
868597006898	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
868597006899	Predicted membrane protein [Function unknown]; Region: COG4655
868597006900	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
868597006901	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
868597006902	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
868597006903	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
868597006904	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597006905	Transmembrane secretion effector; Region: MFS_3; pfam05977
868597006906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597006907	putative substrate translocation pore; other site
868597006908	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
868597006909	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
868597006910	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
868597006911	active site
868597006912	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
868597006913	Isochorismatase family; Region: Isochorismatase; pfam00857
868597006914	catalytic triad [active]
868597006915	dimer interface [polypeptide binding]; other site
868597006916	conserved cis-peptide bond; other site
868597006917	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597006918	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597006919	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597006920	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
868597006921	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
868597006922	Histidine kinase; Region: HisKA_3; pfam07730
868597006923	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597006924	ATP binding site [chemical binding]; other site
868597006925	Mg2+ binding site [ion binding]; other site
868597006926	G-X-G motif; other site
868597006927	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597006928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597006929	active site
868597006930	phosphorylation site [posttranslational modification]
868597006931	intermolecular recognition site; other site
868597006932	dimerization interface [polypeptide binding]; other site
868597006933	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597006934	DNA binding residues [nucleotide binding]
868597006935	dimerization interface [polypeptide binding]; other site
868597006936	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
868597006937	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
868597006938	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
868597006939	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
868597006940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
868597006941	active site
868597006942	dimerization interface [polypeptide binding]; other site
868597006943	LytTr DNA-binding domain; Region: LytTR; smart00850
868597006944	Histidine kinase; Region: His_kinase; pfam06580
868597006945	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
868597006946	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
868597006947	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
868597006948	active site
868597006949	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
868597006950	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
868597006951	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
868597006952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597006953	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597006954	dimerization interface [polypeptide binding]; other site
868597006955	Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
868597006956	cytosine deaminase; Provisional; Region: PRK05985
868597006957	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
868597006958	active site
868597006959	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597006960	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006961	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597006962	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
868597006963	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597006964	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
868597006965	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
868597006966	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
868597006967	D-lactate dehydrogenase; Provisional; Region: PRK11183
868597006968	FAD binding domain; Region: FAD_binding_4; pfam01565
868597006969	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
868597006970	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
868597006971	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
868597006972	phosphate binding site [ion binding]; other site
868597006973	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
868597006974	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
868597006975	DNA-binding site [nucleotide binding]; DNA binding site
868597006976	FCD domain; Region: FCD; pfam07729
868597006977	L-lactate permease; Provisional; Region: PRK10420
868597006978	glycolate transporter; Provisional; Region: PRK09695
868597006979	MgtC family; Region: MgtC; pfam02308
868597006980	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
868597006981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597006982	NAD(P) binding site [chemical binding]; other site
868597006983	active site
868597006984	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597006985	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597006986	Predicted acyl esterases [General function prediction only]; Region: COG2936
868597006987	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
868597006988	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
868597006989	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
868597006990	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597006991	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597006992	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597006993	putative effector binding pocket; other site
868597006994	dimerization interface [polypeptide binding]; other site
868597006995	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
868597006996	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
868597006997	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
868597006998	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597006999	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
868597007000	active site
868597007001	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
868597007002	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
868597007003	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
868597007004	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597007005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597007006	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597007007	putative effector binding pocket; other site
868597007008	dimerization interface [polypeptide binding]; other site
868597007009	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
868597007010	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
868597007011	Putative cyclase; Region: Cyclase; pfam04199
868597007012	Uncharacterized conserved protein [Function unknown]; Region: COG4544
868597007013	DNA Polymerase Y-family; Region: PolY_like; cd03468
868597007014	active site
868597007015	DNA binding site [nucleotide binding]
868597007016	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
868597007017	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
868597007018	putative active site [active]
868597007019	putative PHP Thumb interface [polypeptide binding]; other site
868597007020	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
868597007021	generic binding surface II; other site
868597007022	generic binding surface I; other site
868597007023	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
868597007024	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
868597007025	DNA-binding site [nucleotide binding]; DNA binding site
868597007026	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597007027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597007028	homodimer interface [polypeptide binding]; other site
868597007029	catalytic residue [active]
868597007030	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
868597007031	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
868597007032	catalytic residue [active]
868597007033	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
868597007034	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
868597007035	catalytic triad [active]
868597007036	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
868597007037	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597007038	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597007039	DNA binding residues [nucleotide binding]
868597007040	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
868597007041	FecR protein; Region: FecR; pfam04773
868597007042	Secretin and TonB N terminus short domain; Region: STN; smart00965
868597007043	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597007044	N-terminal plug; other site
868597007045	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
868597007046	ligand-binding site [chemical binding]; other site
868597007047	Protein of unknown function, DUF399; Region: DUF399; cl01139
868597007048	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
868597007049	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
868597007050	homotrimer interaction site [polypeptide binding]; other site
868597007051	putative active site [active]
868597007052	Cation efflux family; Region: Cation_efflux; cl00316
868597007053	arginine decarboxylase; Provisional; Region: PRK15029
868597007054	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
868597007055	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
868597007056	homodimer interface [polypeptide binding]; other site
868597007057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597007058	catalytic residue [active]
868597007059	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
868597007060	arginine:agmatin antiporter; Provisional; Region: PRK10644
868597007061	Porin subfamily; Region: Porin_2; pfam02530
868597007062	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
868597007063	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
868597007064	dimer interface [polypeptide binding]; other site
868597007065	catalytic residues [active]
868597007066	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
868597007067	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
868597007068	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
868597007069	catalytic residues [active]
868597007070	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
868597007071	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
868597007072	conserved cys residue [active]
868597007073	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597007074	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
868597007075	DNA binding residues [nucleotide binding]
868597007076	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
868597007077	dimer interface [polypeptide binding]; other site
868597007078	metal binding site [ion binding]; metal-binding site
868597007079	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597007080	Coenzyme A binding pocket [chemical binding]; other site
868597007081	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597007082	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
868597007083	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597007084	phosphorylation site [posttranslational modification]
868597007085	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
868597007086	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597007087	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597007088	Coenzyme A binding pocket [chemical binding]; other site
868597007089	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597007090	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597007091	metal binding site [ion binding]; metal-binding site
868597007092	active site
868597007093	I-site; other site
868597007094	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597007095	PAS domain; Region: PAS_9; pfam13426
868597007096	putative active site [active]
868597007097	heme pocket [chemical binding]; other site
868597007098	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597007099	PAS domain; Region: PAS_9; pfam13426
868597007100	putative active site [active]
868597007101	heme pocket [chemical binding]; other site
868597007102	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597007103	dimer interface [polypeptide binding]; other site
868597007104	putative CheW interface [polypeptide binding]; other site
868597007105	Right handed beta helix region; Region: Beta_helix; pfam13229
868597007106	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
868597007107	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597007108	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597007109	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597007110	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
868597007111	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597007112	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
868597007113	dimerization interface [polypeptide binding]; other site
868597007114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597007115	dimer interface [polypeptide binding]; other site
868597007116	phosphorylation site [posttranslational modification]
868597007117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597007118	ATP binding site [chemical binding]; other site
868597007119	Mg2+ binding site [ion binding]; other site
868597007120	G-X-G motif; other site
868597007121	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597007122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597007123	active site
868597007124	phosphorylation site [posttranslational modification]
868597007125	intermolecular recognition site; other site
868597007126	dimerization interface [polypeptide binding]; other site
868597007127	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597007128	DNA binding site [nucleotide binding]
868597007129	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597007130	PAS fold; Region: PAS_3; pfam08447
868597007131	putative active site [active]
868597007132	heme pocket [chemical binding]; other site
868597007133	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597007134	PAS domain; Region: PAS_9; pfam13426
868597007135	putative active site [active]
868597007136	heme pocket [chemical binding]; other site
868597007137	PAS domain S-box; Region: sensory_box; TIGR00229
868597007138	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597007139	putative active site [active]
868597007140	heme pocket [chemical binding]; other site
868597007141	PAS fold; Region: PAS_4; pfam08448
868597007142	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
868597007143	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597007144	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597007145	metal binding site [ion binding]; metal-binding site
868597007146	active site
868597007147	I-site; other site
868597007148	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
868597007149	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
868597007150	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
868597007151	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
868597007152	RNA binding site [nucleotide binding]; other site
868597007153	PspC domain; Region: PspC; pfam04024
868597007154	hypothetical protein; Provisional; Region: PRK10318
868597007155	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
868597007156	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; pfam09712
868597007157	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
868597007158	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
868597007159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597007160	S-adenosylmethionine binding site [chemical binding]; other site
868597007161	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
868597007162	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
868597007163	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
868597007164	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
868597007165	putative active site [active]
868597007166	nucleotide binding site [chemical binding]; other site
868597007167	nudix motif; other site
868597007168	putative metal binding site [ion binding]; other site
868597007169	Protein of unknown function (DUF1249); Region: DUF1249; cl01223
868597007170	PEP synthetase regulatory protein; Provisional; Region: PRK05339
868597007171	phosphoenolpyruvate synthase; Validated; Region: PRK06464
868597007172	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
868597007173	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
868597007174	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
868597007175	Mechanosensitive ion channel; Region: MS_channel; pfam00924
868597007176	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
868597007177	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
868597007178	FMN binding site [chemical binding]; other site
868597007179	active site
868597007180	substrate binding site [chemical binding]; other site
868597007181	catalytic residue [active]
868597007182	EcsC protein family; Region: EcsC; pfam12787
868597007183	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
868597007184	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
868597007185	catalytic site [active]
868597007186	putative active site [active]
868597007187	putative substrate binding site [chemical binding]; other site
868597007188	dimer interface [polypeptide binding]; other site
868597007189	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
868597007190	nucleoside/Zn binding site; other site
868597007191	dimer interface [polypeptide binding]; other site
868597007192	catalytic motif [active]
868597007193	Predicted transcriptional regulators [Transcription]; Region: COG1733
868597007194	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
868597007195	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
868597007196	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597007197	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597007198	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
868597007199	Coenzyme A binding pocket [chemical binding]; other site
868597007200	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
868597007201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597007202	Coenzyme A binding pocket [chemical binding]; other site
868597007203	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
868597007204	nucleophilic elbow; other site
868597007205	catalytic triad; other site
868597007206	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
868597007207	catalytic residue [active]
868597007208	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
868597007209	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
868597007210	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
868597007211	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
868597007212	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
868597007213	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
868597007214	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
868597007215	TrbC/VIRB2 family; Region: TrbC; pfam04956
868597007216	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
868597007217	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597007218	catalytic residue [active]
868597007219	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
868597007220	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
868597007221	Walker A motif; other site
868597007222	hexamer interface [polypeptide binding]; other site
868597007223	ATP binding site [chemical binding]; other site
868597007224	Walker B motif; other site
868597007225	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
868597007226	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
868597007227	VirB7 interaction site; other site
868597007228	VirB8 protein; Region: VirB8; pfam04335
868597007229	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
868597007230	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
868597007231	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
868597007232	Walker A motif; other site
868597007233	ATP binding site [chemical binding]; other site
868597007234	Walker B motif; other site
868597007235	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
868597007236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597007237	putative substrate translocation pore; other site
868597007238	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
868597007239	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
868597007240	DNA binding residues [nucleotide binding]
868597007241	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
868597007242	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
868597007243	putative active site [active]
868597007244	putative FMN binding site [chemical binding]; other site
868597007245	putative substrate binding site [chemical binding]; other site
868597007246	putative catalytic residue [active]
868597007247	hypothetical protein; Provisional; Region: PRK06834
868597007248	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
868597007249	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597007250	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597007251	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
868597007252	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597007253	N-terminal plug; other site
868597007254	ligand-binding site [chemical binding]; other site
868597007255	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597007256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597007257	active site
868597007258	phosphorylation site [posttranslational modification]
868597007259	intermolecular recognition site; other site
868597007260	dimerization interface [polypeptide binding]; other site
868597007261	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597007262	DNA binding site [nucleotide binding]
868597007263	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597007264	HAMP domain; Region: HAMP; pfam00672
868597007265	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597007266	dimer interface [polypeptide binding]; other site
868597007267	phosphorylation site [posttranslational modification]
868597007268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597007269	ATP binding site [chemical binding]; other site
868597007270	Mg2+ binding site [ion binding]; other site
868597007271	G-X-G motif; other site
868597007272	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597007273	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597007274	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597007275	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
868597007276	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
868597007277	Walker A/P-loop; other site
868597007278	ATP binding site [chemical binding]; other site
868597007279	Q-loop/lid; other site
868597007280	ABC transporter signature motif; other site
868597007281	Walker B; other site
868597007282	D-loop; other site
868597007283	H-loop/switch region; other site
868597007284	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597007285	FtsX-like permease family; Region: FtsX; pfam02687
868597007286	BA14K-like protein; Region: BA14K; pfam07886
868597007287	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
868597007288	Ca2+ binding site [ion binding]; other site
868597007289	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
868597007290	EF-hand domain pair; Region: EF_hand_5; pfam13499
868597007291	Ca2+ binding site [ion binding]; other site
868597007292	Predicted transcriptional regulators [Transcription]; Region: COG1733
868597007293	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
868597007294	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
868597007295	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
868597007296	NADP binding site [chemical binding]; other site
868597007297	dimer interface [polypeptide binding]; other site
868597007298	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
868597007299	Part of AAA domain; Region: AAA_19; pfam13245
868597007300	Family description; Region: UvrD_C_2; pfam13538
868597007301	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
868597007302	LysR family transcriptional regulator; Provisional; Region: PRK14997
868597007303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597007304	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
868597007305	putative effector binding pocket; other site
868597007306	putative dimerization interface [polypeptide binding]; other site
868597007307	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
868597007308	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597007309	Src Homology 3 domain superfamily; Region: SH3; cl17036
868597007310	peptide ligand binding site [polypeptide binding]; other site
868597007311	seryl-tRNA synthetase; Provisional; Region: PRK05431
868597007312	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
868597007313	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
868597007314	dimer interface [polypeptide binding]; other site
868597007315	active site
868597007316	motif 1; other site
868597007317	motif 2; other site
868597007318	motif 3; other site
868597007319	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597007320	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
868597007321	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
868597007322	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597007323	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
868597007324	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
868597007325	hinge; other site
868597007326	active site
868597007327	Chorismate mutase type II; Region: CM_2; pfam01817
868597007328	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
868597007329	Prephenate dehydratase; Region: PDT; pfam00800
868597007330	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
868597007331	putative L-Phe binding site [chemical binding]; other site
868597007332	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
868597007333	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597007334	catalytic residue [active]
868597007335	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
868597007336	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
868597007337	phosphopeptide binding site; other site
868597007338	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650
868597007339	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
868597007340	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
868597007341	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
868597007342	DNA-binding site [nucleotide binding]; DNA binding site
868597007343	UTRA domain; Region: UTRA; pfam07702
868597007344	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
868597007345	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
868597007346	active site
868597007347	imidazolonepropionase; Validated; Region: PRK09356
868597007348	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
868597007349	active site
868597007350	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
868597007351	active sites [active]
868597007352	tetramer interface [polypeptide binding]; other site
868597007353	N-formylglutamate amidohydrolase; Region: FGase; cl01522
868597007354	urocanate hydratase; Provisional; Region: PRK05414
868597007355	GAD-like domain; Region: GAD-like; pfam08887
868597007356	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
868597007357	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
868597007358	Beta-lactamase; Region: Beta-lactamase; pfam00144
868597007359	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597007360	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597007361	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597007362	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597007363	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
868597007364	active site
868597007365	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
868597007366	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
868597007367	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
868597007368	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597007369	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597007370	dimerization interface [polypeptide binding]; other site
868597007371	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501
868597007372	active site
868597007373	catalytic triad [active]
868597007374	oxyanion hole [active]
868597007375	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316
868597007376	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
868597007377	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
868597007378	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597007379	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cl09113
868597007380	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
868597007381	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597007382	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597007383	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
868597007384	putative effector binding pocket; other site
868597007385	putative dimerization interface [polypeptide binding]; other site
868597007386	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
868597007387	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
868597007388	putative NAD(P) binding site [chemical binding]; other site
868597007389	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
868597007390	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
868597007391	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
868597007392	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
868597007393	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
868597007394	Trp docking motif [polypeptide binding]; other site
868597007395	putative active site [active]
868597007396	DNA gyrase subunit A; Validated; Region: PRK05560
868597007397	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
868597007398	CAP-like domain; other site
868597007399	active site
868597007400	primary dimer interface [polypeptide binding]; other site
868597007401	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
868597007402	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
868597007403	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
868597007404	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
868597007405	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
868597007406	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
868597007407	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
868597007408	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
868597007409	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
868597007410	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
868597007411	motif 1; other site
868597007412	dimer interface [polypeptide binding]; other site
868597007413	active site
868597007414	motif 2; other site
868597007415	motif 3; other site
868597007416	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
868597007417	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597007418	Coenzyme A binding pocket [chemical binding]; other site
868597007419	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
868597007420	DNA ligase, NAD-dependent; Region: dnlj; TIGR00575
868597007421	nucleotide binding pocket [chemical binding]; other site
868597007422	K-X-D-G motif; other site
868597007423	catalytic site [active]
868597007424	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
868597007425	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
868597007426	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
868597007427	Dimer interface [polypeptide binding]; other site
868597007428	BRCT sequence motif; other site
868597007429	putative aminotransferase; Provisional; Region: PRK09105
868597007430	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597007431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597007432	homodimer interface [polypeptide binding]; other site
868597007433	catalytic residue [active]
868597007434	Transposase IS200 like; Region: Y1_Tnp; pfam01797
868597007435	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
868597007436	FtsZ protein binding site [polypeptide binding]; other site
868597007437	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
868597007438	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
868597007439	Walker A/P-loop; other site
868597007440	ATP binding site [chemical binding]; other site
868597007441	Q-loop/lid; other site
868597007442	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
868597007443	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
868597007444	ABC transporter signature motif; other site
868597007445	Walker B; other site
868597007446	D-loop; other site
868597007447	H-loop/switch region; other site
868597007448	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
868597007449	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
868597007450	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
868597007451	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
868597007452	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
868597007453	Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691
868597007454	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
868597007455	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
868597007456	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
868597007457	putative anticodon binding site; other site
868597007458	putative dimer interface [polypeptide binding]; other site
868597007459	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
868597007460	homodimer interface [polypeptide binding]; other site
868597007461	motif 1; other site
868597007462	motif 2; other site
868597007463	active site
868597007464	motif 3; other site
868597007465	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
868597007466	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
868597007467	active site clefts [active]
868597007468	zinc binding site [ion binding]; other site
868597007469	dimer interface [polypeptide binding]; other site
868597007470	3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264
868597007471	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
868597007472	kynureninase; Region: kynureninase; TIGR01814
868597007473	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597007474	catalytic residue [active]
868597007475	FAD binding domain; Region: FAD_binding_3; pfam01494
868597007476	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
868597007477	exonuclease I; Provisional; Region: sbcB; PRK11779
868597007478	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
868597007479	active site
868597007480	catalytic site [active]
868597007481	substrate binding site [chemical binding]; other site
868597007482	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
868597007483	TIGR02453 family protein; Region: TIGR02453
868597007484	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
868597007485	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
868597007486	ATP-NAD kinase; Region: NAD_kinase; pfam01513
868597007487	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
868597007488	Glutamate dehydrogenase N terminal; Region: GDH_N; pfam12466
868597007489	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
868597007490	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
868597007491	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597007492	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597007493	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
868597007494	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597007495	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597007496	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597007497	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
868597007498	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
868597007499	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
868597007500	active site
868597007501	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597007502	dimerization interface [polypeptide binding]; other site
868597007503	putative DNA binding site [nucleotide binding]; other site
868597007504	putative Zn2+ binding site [ion binding]; other site
868597007505	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597007506	Methyltransferase domain; Region: Methyltransf_31; pfam13847
868597007507	S-adenosylmethionine binding site [chemical binding]; other site
868597007508	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
868597007509	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
868597007510	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
868597007511	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
868597007512	substrate binding pocket [chemical binding]; other site
868597007513	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
868597007514	B12 binding site [chemical binding]; other site
868597007515	cobalt ligand [ion binding]; other site
868597007516	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
868597007517	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
868597007518	MFS_1 like family; Region: MFS_1_like; pfam12832
868597007519	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201
868597007520	hypothetical protein; Provisional; Region: PRK00846
868597007521	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
868597007522	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
868597007523	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
868597007524	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
868597007525	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
868597007526	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
868597007527	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
868597007528	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
868597007529	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
868597007530	catalytic residues [active]
868597007531	dimer interface [polypeptide binding]; other site
868597007532	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
868597007533	DNA-binding site [nucleotide binding]; DNA binding site
868597007534	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
868597007535	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
868597007536	Walker A/P-loop; other site
868597007537	ATP binding site [chemical binding]; other site
868597007538	Q-loop/lid; other site
868597007539	ABC transporter signature motif; other site
868597007540	Walker B; other site
868597007541	D-loop; other site
868597007542	H-loop/switch region; other site
868597007543	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
868597007544	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
868597007545	fumarate hydratase; Reviewed; Region: fumC; PRK00485
868597007546	Class II fumarases; Region: Fumarase_classII; cd01362
868597007547	active site
868597007548	tetramer interface [polypeptide binding]; other site
868597007549	adenylosuccinate lyase; Provisional; Region: PRK09285
868597007550	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
868597007551	tetramer interface [polypeptide binding]; other site
868597007552	active site
868597007553	Uncharacterized conserved protein [Function unknown]; Region: COG2850
868597007554	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
868597007555	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597007556	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
868597007557	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
868597007558	TPP-binding site [chemical binding]; other site
868597007559	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
868597007560	dimer interface [polypeptide binding]; other site
868597007561	PYR/PP interface [polypeptide binding]; other site
868597007562	TPP binding site [chemical binding]; other site
868597007563	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
868597007564	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
868597007565	E3 interaction surface; other site
868597007566	lipoyl attachment site [posttranslational modification]; other site
868597007567	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
868597007568	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
868597007569	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
868597007570	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
868597007571	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
868597007572	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597007573	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597007574	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
868597007575	dimerization interface [polypeptide binding]; other site
868597007576	glutathionine S-transferase; Provisional; Region: PRK10542
868597007577	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
868597007578	C-terminal domain interface [polypeptide binding]; other site
868597007579	GSH binding site (G-site) [chemical binding]; other site
868597007580	dimer interface [polypeptide binding]; other site
868597007581	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
868597007582	dimer interface [polypeptide binding]; other site
868597007583	N-terminal domain interface [polypeptide binding]; other site
868597007584	substrate binding pocket (H-site) [chemical binding]; other site
868597007585	PhoD-like phosphatase; Region: PhoD; pfam09423
868597007586	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
868597007587	putative active site [active]
868597007588	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
868597007589	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597007590	N-terminal plug; other site
868597007591	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597007592	ligand-binding site [chemical binding]; other site
868597007593	replicative DNA helicase; Provisional; Region: PRK08760
868597007594	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
868597007595	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
868597007596	Walker A motif; other site
868597007597	ATP binding site [chemical binding]; other site
868597007598	Walker B motif; other site
868597007599	DNA binding loops [nucleotide binding]
868597007600	Predicted flavoprotein [General function prediction only]; Region: COG0431
868597007601	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597007602	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
868597007603	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
868597007604	dimer interface [polypeptide binding]; other site
868597007605	active site
868597007606	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
868597007607	Ligand Binding Site [chemical binding]; other site
868597007608	Molecular Tunnel; other site
868597007609	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
868597007610	TPP-binding site [chemical binding]; other site
868597007611	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
868597007612	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
868597007613	PYR/PP interface [polypeptide binding]; other site
868597007614	dimer interface [polypeptide binding]; other site
868597007615	TPP binding site [chemical binding]; other site
868597007616	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
868597007617	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
868597007618	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
868597007619	putative C-terminal domain interface [polypeptide binding]; other site
868597007620	putative GSH binding site (G-site) [chemical binding]; other site
868597007621	putative dimer interface [polypeptide binding]; other site
868597007622	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
868597007623	N-terminal domain interface [polypeptide binding]; other site
868597007624	dimer interface [polypeptide binding]; other site
868597007625	substrate binding pocket (H-site) [chemical binding]; other site
868597007626	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
868597007627	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
868597007628	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
868597007629	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
868597007630	active site
868597007631	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
868597007632	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
868597007633	putative ATP binding site [chemical binding]; other site
868597007634	putative substrate interface [chemical binding]; other site
868597007635	Cytochrome C' Region: Cytochrom_C_2; cl01610
868597007636	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
868597007637	DNA-binding site [nucleotide binding]; DNA binding site
868597007638	RNA-binding motif; other site
868597007639	Protein of unknown function (DUF456); Region: DUF456; pfam04306
868597007640	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
868597007641	dimerization interface [polypeptide binding]; other site
868597007642	substrate binding site [chemical binding]; other site
868597007643	active site
868597007644	calcium binding site [ion binding]; other site
868597007645	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
868597007646	ArsC family; Region: ArsC; pfam03960
868597007647	catalytic residues [active]
868597007648	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
868597007649	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
868597007650	C-terminal domain interface [polypeptide binding]; other site
868597007651	GSH binding site (G-site) [chemical binding]; other site
868597007652	dimer interface [polypeptide binding]; other site
868597007653	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
868597007654	dimer interface [polypeptide binding]; other site
868597007655	N-terminal domain interface [polypeptide binding]; other site
868597007656	substrate binding pocket (H-site) [chemical binding]; other site
868597007657	putative fumarate hydratase; Provisional; Region: PRK15392
868597007658	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
868597007659	Fumarase C-terminus; Region: Fumerase_C; pfam05683
868597007660	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
868597007661	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597007662	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597007663	DNA binding residues [nucleotide binding]
868597007664	Uncharacterized conserved protein [Function unknown]; Region: COG2128
868597007665	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
868597007666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597007667	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
868597007668	Walker A/P-loop; other site
868597007669	ATP binding site [chemical binding]; other site
868597007670	Q-loop/lid; other site
868597007671	ABC transporter signature motif; other site
868597007672	Walker B; other site
868597007673	D-loop; other site
868597007674	H-loop/switch region; other site
868597007675	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
868597007676	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
868597007677	FAD binding pocket [chemical binding]; other site
868597007678	FAD binding motif [chemical binding]; other site
868597007679	phosphate binding motif [ion binding]; other site
868597007680	beta-alpha-beta structure motif; other site
868597007681	NAD binding pocket [chemical binding]; other site
868597007682	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
868597007683	catalytic residues [active]
868597007684	dimer interface [polypeptide binding]; other site
868597007685	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
868597007686	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
868597007687	active site
868597007688	Zn binding site [ion binding]; other site
868597007689	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
868597007690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597007691	S-adenosylmethionine binding site [chemical binding]; other site
868597007692	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
868597007693	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
868597007694	Predicted acetyltransferase [General function prediction only]; Region: COG2388
868597007695	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
868597007696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597007697	POT family; Region: PTR2; cl17359
868597007698	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
868597007699	putative catalytic site [active]
868597007700	putative metal binding site [ion binding]; other site
868597007701	putative phosphate binding site [ion binding]; other site
868597007702	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
868597007703	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
868597007704	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
868597007705	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
868597007706	active site
868597007707	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
868597007708	putative RNAase interaction site [polypeptide binding]; other site
868597007709	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
868597007710	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
868597007711	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
868597007712	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
868597007713	aromatic arch; other site
868597007714	DCoH dimer interaction site [polypeptide binding]; other site
868597007715	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
868597007716	DCoH tetramer interaction site [polypeptide binding]; other site
868597007717	substrate binding site [chemical binding]; other site
868597007718	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
868597007719	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597007720	zinc transporter ZupT; Provisional; Region: PRK04201
868597007721	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
868597007722	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597007723	RNA binding surface [nucleotide binding]; other site
868597007724	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
868597007725	active site
868597007726	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
868597007727	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
868597007728	homodimer interface [polypeptide binding]; other site
868597007729	oligonucleotide binding site [chemical binding]; other site
868597007730	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
868597007731	putative catalytic site [active]
868597007732	putative metal binding site [ion binding]; other site
868597007733	putative phosphate binding site [ion binding]; other site
868597007734	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
868597007735	sugar binding site [chemical binding]; other site
868597007736	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
868597007737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597007738	dimer interface [polypeptide binding]; other site
868597007739	conserved gate region; other site
868597007740	putative PBP binding loops; other site
868597007741	ABC-ATPase subunit interface; other site
868597007742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597007743	dimer interface [polypeptide binding]; other site
868597007744	conserved gate region; other site
868597007745	putative PBP binding loops; other site
868597007746	ABC-ATPase subunit interface; other site
868597007747	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
868597007748	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
868597007749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
868597007750	Putative glucoamylase; Region: Glycoamylase; pfam10091
868597007751	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
868597007752	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597007753	Transcriptional regulators [Transcription]; Region: PurR; COG1609
868597007754	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
868597007755	DNA binding site [nucleotide binding]
868597007756	domain linker motif; other site
868597007757	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
868597007758	dimerization interface [polypeptide binding]; other site
868597007759	ligand binding site [chemical binding]; other site
868597007760	BolA-like protein; Region: BolA; pfam01722
868597007761	YciI-like protein; Reviewed; Region: PRK11370
868597007762	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
868597007763	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
868597007764	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
868597007765	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597007766	RNA binding surface [nucleotide binding]; other site
868597007767	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
868597007768	active site
868597007769	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
868597007770	Helix-turn-helix domain; Region: HTH_18; pfam12833
868597007771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597007772	C-N hydrolase family amidase; Provisional; Region: PRK10438
868597007773	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
868597007774	putative active site [active]
868597007775	catalytic triad [active]
868597007776	dimer interface [polypeptide binding]; other site
868597007777	multimer interface [polypeptide binding]; other site
868597007778	methionine aminotransferase; Validated; Region: PRK09082
868597007779	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597007780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597007781	homodimer interface [polypeptide binding]; other site
868597007782	catalytic residue [active]
868597007783	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13543
868597007784	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597007785	Walker A/P-loop; other site
868597007786	ATP binding site [chemical binding]; other site
868597007787	Q-loop/lid; other site
868597007788	ABC transporter signature motif; other site
868597007789	Walker B; other site
868597007790	D-loop; other site
868597007791	H-loop/switch region; other site
868597007792	CcmB protein; Region: CcmB; cl17444
868597007793	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
868597007794	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
868597007795	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
868597007796	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
868597007797	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
868597007798	catalytic residues [active]
868597007799	central insert; other site
868597007800	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
868597007801	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
868597007802	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
868597007803	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
868597007804	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
868597007805	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
868597007806	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
868597007807	Walker A/P-loop; other site
868597007808	ATP binding site [chemical binding]; other site
868597007809	Q-loop/lid; other site
868597007810	ABC transporter signature motif; other site
868597007811	Walker B; other site
868597007812	D-loop; other site
868597007813	H-loop/switch region; other site
868597007814	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
868597007815	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597007816	Walker A/P-loop; other site
868597007817	ATP binding site [chemical binding]; other site
868597007818	Q-loop/lid; other site
868597007819	ABC transporter signature motif; other site
868597007820	Walker B; other site
868597007821	D-loop; other site
868597007822	H-loop/switch region; other site
868597007823	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
868597007824	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
868597007825	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
868597007826	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
868597007827	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
868597007828	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
868597007829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597007830	Tetratricopeptide repeat; Region: TPR_16; pfam13432
868597007831	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
868597007832	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
868597007833	putative active site [active]
868597007834	putative metal binding site [ion binding]; other site
868597007835	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
868597007836	putative active site [active]
868597007837	N-glycosyltransferase; Provisional; Region: PRK11204
868597007838	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
868597007839	DXD motif; other site
868597007840	PgaD-like protein; Region: PgaD; pfam13994
868597007841	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
868597007842	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
868597007843	putative catalytic cysteine [active]
868597007844	gamma-glutamyl kinase; Provisional; Region: PRK05429
868597007845	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
868597007846	nucleotide binding site [chemical binding]; other site
868597007847	PUA domain; Region: PUA; pfam01472
868597007848	YCII-related domain; Region: YCII; cl00999
868597007849	argininosuccinate lyase; Provisional; Region: PRK00855
868597007850	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
868597007851	active sites [active]
868597007852	tetramer interface [polypeptide binding]; other site
868597007853	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
868597007854	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
868597007855	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
868597007856	acetylglutamate kinase; Provisional; Region: PRK04531
868597007857	AAK_NAGK-fArgBP: N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal...; Region: AAK_NAGK-fArgBP; cd04252
868597007858	putative nucleotide binding site [chemical binding]; other site
868597007859	putative N-acetyl-L-glutamate binding site [chemical binding]; other site
868597007860	DUF619 domain of various N-acetylglutamate Synthases of the fungal arginine-biosynthetic pathway and urea cycle found in humans and fish; Region: DUF619-NAGS; cd04264
868597007861	acetylornithine deacetylase; Provisional; Region: PRK08737
868597007862	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
868597007863	metal binding site [ion binding]; metal-binding site
868597007864	putative dimer interface [polypeptide binding]; other site
868597007865	argininosuccinate synthase; Provisional; Region: PRK13820
868597007866	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
868597007867	ANP binding site [chemical binding]; other site
868597007868	Substrate Binding Site II [chemical binding]; other site
868597007869	Substrate Binding Site I [chemical binding]; other site
868597007870	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
868597007871	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
868597007872	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
868597007873	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
868597007874	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
868597007875	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
868597007876	active site
868597007877	HIGH motif; other site
868597007878	nucleotide binding site [chemical binding]; other site
868597007879	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
868597007880	KMSKS motif; other site
868597007881	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
868597007882	tRNA binding surface [nucleotide binding]; other site
868597007883	anticodon binding site; other site
868597007884	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
868597007885	H+ Antiporter protein; Region: 2A0121; TIGR00900
868597007886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597007887	putative substrate translocation pore; other site
868597007888	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
868597007889	hypothetical protein; Validated; Region: PRK00041
868597007890	dihydroorotase; Reviewed; Region: PRK09236
868597007891	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
868597007892	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
868597007893	active site
868597007894	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
868597007895	Peptidase family M23; Region: Peptidase_M23; pfam01551
868597007896	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
868597007897	phosphoglycolate phosphatase; Provisional; Region: PRK13226
868597007898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597007899	motif II; other site
868597007900	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
868597007901	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597007902	S-adenosylmethionine binding site [chemical binding]; other site
868597007903	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
868597007904	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
868597007905	active site
868597007906	putative substrate binding pocket [chemical binding]; other site
868597007907	elongation factor P; Validated; Region: PRK00529
868597007908	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
868597007909	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
868597007910	RNA binding site [nucleotide binding]; other site
868597007911	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
868597007912	RNA binding site [nucleotide binding]; other site
868597007913	Radical SAM superfamily; Region: Radical_SAM; pfam04055
868597007914	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597007915	FeS/SAM binding site; other site
868597007916	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
868597007917	dimerization interface [polypeptide binding]; other site
868597007918	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597007919	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597007920	metal binding site [ion binding]; metal-binding site
868597007921	active site
868597007922	I-site; other site
868597007923	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597007924	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
868597007925	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
868597007926	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
868597007927	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
868597007928	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
868597007929	active site
868597007930	dimerization interface [polypeptide binding]; other site
868597007931	heat shock protein HtpX; Provisional; Region: PRK05457
868597007932	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
868597007933	active site
868597007934	HIGH motif; other site
868597007935	nucleotide binding site [chemical binding]; other site
868597007936	KMSKS motif; other site
868597007937	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
868597007938	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
868597007939	NAD(P) binding site [chemical binding]; other site
868597007940	homotetramer interface [polypeptide binding]; other site
868597007941	homodimer interface [polypeptide binding]; other site
868597007942	active site
868597007943	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
868597007944	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
868597007945	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
868597007946	TraB family; Region: TraB; pfam01963
868597007947	Protein of unknown function (DUF1684); Region: DUF1684; cl01327
868597007948	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
868597007949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597007950	ATP binding site [chemical binding]; other site
868597007951	Mg2+ binding site [ion binding]; other site
868597007952	G-X-G motif; other site
868597007953	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
868597007954	ATP binding site [chemical binding]; other site
868597007955	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
868597007956	AMIN domain; Region: AMIN; pfam11741
868597007957	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
868597007958	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
868597007959	active site
868597007960	metal binding site [ion binding]; metal-binding site
868597007961	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
868597007962	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
868597007963	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
868597007964	putative substrate binding site [chemical binding]; other site
868597007965	putative ATP binding site [chemical binding]; other site
868597007966	epoxyqueuosine reductase; Region: TIGR00276
868597007967	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
868597007968	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
868597007969	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
868597007970	generic binding surface II; other site
868597007971	generic binding surface I; other site
868597007972	Peptidase family M48; Region: Peptidase_M48; pfam01435
868597007973	TPR repeat; Region: TPR_11; pfam13414
868597007974	Uncharacterized conserved protein [Function unknown]; Region: COG1262
868597007975	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
868597007976	ribonuclease D; Region: rnd; TIGR01388
868597007977	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
868597007978	catalytic site [active]
868597007979	putative active site [active]
868597007980	putative substrate binding site [chemical binding]; other site
868597007981	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
868597007982	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
868597007983	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597007984	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597007985	N-terminal plug; other site
868597007986	ligand-binding site [chemical binding]; other site
868597007987	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597007988	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597007989	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
868597007990	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
868597007991	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
868597007992	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
868597007993	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
868597007994	short chain dehydrogenase; Provisional; Region: PRK07478
868597007995	classical (c) SDRs; Region: SDR_c; cd05233
868597007996	NAD(P) binding site [chemical binding]; other site
868597007997	active site
868597007998	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597007999	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597008000	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597008001	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
868597008002	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
868597008003	DNA binding site [nucleotide binding]
868597008004	active site
868597008005	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
868597008006	Prostaglandin dehydrogenases; Region: PGDH; cd05288
868597008007	NAD(P) binding site [chemical binding]; other site
868597008008	substrate binding site [chemical binding]; other site
868597008009	dimer interface [polypeptide binding]; other site
868597008010	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
868597008011	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
868597008012	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
868597008013	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
868597008014	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
868597008015	active site
868597008016	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
868597008017	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
868597008018	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
868597008019	active site
868597008020	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
868597008021	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
868597008022	TPP-binding site; other site
868597008023	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
868597008024	PYR/PP interface [polypeptide binding]; other site
868597008025	dimer interface [polypeptide binding]; other site
868597008026	TPP binding site [chemical binding]; other site
868597008027	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
868597008028	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
868597008029	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597008030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597008031	active site
868597008032	phosphorylation site [posttranslational modification]
868597008033	intermolecular recognition site; other site
868597008034	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597008035	DNA binding residues [nucleotide binding]
868597008036	dimerization interface [polypeptide binding]; other site
868597008037	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
868597008038	G1 box; other site
868597008039	GTP/Mg2+ binding site [chemical binding]; other site
868597008040	G2 box; other site
868597008041	Switch I region; other site
868597008042	G3 box; other site
868597008043	Switch II region; other site
868597008044	G4 box; other site
868597008045	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
868597008046	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
868597008047	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
868597008048	Pilin (bacterial filament); Region: Pilin; pfam00114
868597008049	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
868597008050	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
868597008051	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597008052	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
868597008053	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
868597008054	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
868597008055	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
868597008056	oligomer interface [polypeptide binding]; other site
868597008057	active site residues [active]
868597008058	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
868597008059	hydrophobic ligand binding site; other site
868597008060	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597008061	dimerization interface [polypeptide binding]; other site
868597008062	putative DNA binding site [nucleotide binding]; other site
868597008063	putative Zn2+ binding site [ion binding]; other site
868597008064	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
868597008065	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
868597008066	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597008067	Coenzyme A binding pocket [chemical binding]; other site
868597008068	Low molecular weight phosphatase family; Region: LMWPc; cl00105
868597008069	active site
868597008070	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
868597008071	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
868597008072	DNA binding residues [nucleotide binding]
868597008073	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
868597008074	IHF dimer interface [polypeptide binding]; other site
868597008075	IHF - DNA interface [nucleotide binding]; other site
868597008076	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
868597008077	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
868597008078	putative tRNA-binding site [nucleotide binding]; other site
868597008079	B3/4 domain; Region: B3_4; pfam03483
868597008080	tRNA synthetase B5 domain; Region: B5; smart00874
868597008081	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
868597008082	dimer interface [polypeptide binding]; other site
868597008083	motif 1; other site
868597008084	motif 3; other site
868597008085	motif 2; other site
868597008086	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
868597008087	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
868597008088	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
868597008089	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
868597008090	dimer interface [polypeptide binding]; other site
868597008091	motif 1; other site
868597008092	active site
868597008093	motif 2; other site
868597008094	motif 3; other site
868597008095	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
868597008096	23S rRNA binding site [nucleotide binding]; other site
868597008097	L21 binding site [polypeptide binding]; other site
868597008098	L13 binding site [polypeptide binding]; other site
868597008099	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
868597008100	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
868597008101	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
868597008102	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
868597008103	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
868597008104	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
868597008105	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
868597008106	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
868597008107	active site
868597008108	dimer interface [polypeptide binding]; other site
868597008109	motif 1; other site
868597008110	motif 2; other site
868597008111	motif 3; other site
868597008112	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
868597008113	anticodon binding site; other site
868597008114	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
868597008115	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
868597008116	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
868597008117	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
868597008118	dimer interface [polypeptide binding]; other site
868597008119	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597008120	metal binding site [ion binding]; metal-binding site
868597008121	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
868597008122	Glyco_18 domain; Region: Glyco_18; smart00636
868597008123	active site
868597008124	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
868597008125	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
868597008126	RNase E interface [polypeptide binding]; other site
868597008127	trimer interface [polypeptide binding]; other site
868597008128	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
868597008129	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
868597008130	RNase E interface [polypeptide binding]; other site
868597008131	trimer interface [polypeptide binding]; other site
868597008132	active site
868597008133	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
868597008134	putative nucleic acid binding region [nucleotide binding]; other site
868597008135	G-X-X-G motif; other site
868597008136	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
868597008137	RNA binding site [nucleotide binding]; other site
868597008138	domain interface; other site
868597008139	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
868597008140	16S/18S rRNA binding site [nucleotide binding]; other site
868597008141	S13e-L30e interaction site [polypeptide binding]; other site
868597008142	25S rRNA binding site [nucleotide binding]; other site
868597008143	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04642
868597008144	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
868597008145	RNA binding site [nucleotide binding]; other site
868597008146	active site
868597008147	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
868597008148	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
868597008149	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
868597008150	translation initiation factor IF-2; Region: IF-2; TIGR00487
868597008151	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
868597008152	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
868597008153	G1 box; other site
868597008154	putative GEF interaction site [polypeptide binding]; other site
868597008155	GTP/Mg2+ binding site [chemical binding]; other site
868597008156	Switch I region; other site
868597008157	G2 box; other site
868597008158	G3 box; other site
868597008159	Switch II region; other site
868597008160	G4 box; other site
868597008161	G5 box; other site
868597008162	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
868597008163	Translation-initiation factor 2; Region: IF-2; pfam11987
868597008164	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
868597008165	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
868597008166	NusA N-terminal domain; Region: NusA_N; pfam08529
868597008167	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
868597008168	RNA binding site [nucleotide binding]; other site
868597008169	homodimer interface [polypeptide binding]; other site
868597008170	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
868597008171	G-X-X-G motif; other site
868597008172	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
868597008173	G-X-X-G motif; other site
868597008174	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
868597008175	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
868597008176	ribosome maturation protein RimP; Reviewed; Region: PRK00092
868597008177	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
868597008178	putative oligomer interface [polypeptide binding]; other site
868597008179	putative RNA binding site [nucleotide binding]; other site
868597008180	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
868597008181	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
868597008182	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
868597008183	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
868597008184	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
868597008185	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
868597008186	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
868597008187	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
868597008188	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
868597008189	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
868597008190	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
868597008191	4Fe-4S binding domain; Region: Fer4; cl02805
868597008192	4Fe-4S binding domain; Region: Fer4; pfam00037
868597008193	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
868597008194	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
868597008195	NADH dehydrogenase subunit G; Validated; Region: PRK09129
868597008196	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
868597008197	catalytic loop [active]
868597008198	iron binding site [ion binding]; other site
868597008199	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
868597008200	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
868597008201	molybdopterin cofactor binding site; other site
868597008202	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
868597008203	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
868597008204	SLBB domain; Region: SLBB; pfam10531
868597008205	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
868597008206	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
868597008207	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
868597008208	putative dimer interface [polypeptide binding]; other site
868597008209	[2Fe-2S] cluster binding site [ion binding]; other site
868597008210	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
868597008211	NADH dehydrogenase subunit D; Validated; Region: PRK06075
868597008212	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
868597008213	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
868597008214	NADH dehydrogenase subunit B; Validated; Region: PRK06411
868597008215	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
868597008216	Preprotein translocase SecG subunit; Region: SecG; pfam03840
868597008217	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
868597008218	substrate binding site [chemical binding]; other site
868597008219	dimer interface [polypeptide binding]; other site
868597008220	catalytic triad [active]
868597008221	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
868597008222	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
868597008223	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
868597008224	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
868597008225	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
868597008226	Sulfatase; Region: Sulfatase; cl17466
868597008227	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
868597008228	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
868597008229	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
868597008230	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
868597008231	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
868597008232	putative active site [active]
868597008233	putative metal binding site [ion binding]; other site
868597008234	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
868597008235	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
868597008236	NAD binding site [chemical binding]; other site
868597008237	homodimer interface [polypeptide binding]; other site
868597008238	active site
868597008239	substrate binding site [chemical binding]; other site
868597008240	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
868597008241	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
868597008242	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
868597008243	active site
868597008244	substrate binding site [chemical binding]; other site
868597008245	metal binding site [ion binding]; metal-binding site
868597008246	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
868597008247	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
868597008248	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
868597008249	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
868597008250	substrate binding site [chemical binding]; other site
868597008251	active site
868597008252	catalytic residues [active]
868597008253	heterodimer interface [polypeptide binding]; other site
868597008254	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
868597008255	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
868597008256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597008257	catalytic residue [active]
868597008258	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
868597008259	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597008260	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597008261	dimerization interface [polypeptide binding]; other site
868597008262	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
868597008263	ATPase involved in DNA repair; Region: DUF3686; pfam12458
868597008264	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
868597008265	Walker A motif; other site
868597008266	ATP binding site [chemical binding]; other site
868597008267	Walker B motif; other site
868597008268	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
868597008269	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
868597008270	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
868597008271	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
868597008272	active site
868597008273	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
868597008274	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
868597008275	dimerization interface 3.5A [polypeptide binding]; other site
868597008276	active site
868597008277	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597008278	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
868597008279	FimV N-terminal domain; Region: FimV_core; TIGR03505
868597008280	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
868597008281	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
868597008282	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
868597008283	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
868597008284	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
868597008285	dimerization interface [polypeptide binding]; other site
868597008286	ligand binding site [chemical binding]; other site
868597008287	NADP binding site [chemical binding]; other site
868597008288	catalytic site [active]
868597008289	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
868597008290	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
868597008291	Tetramer interface [polypeptide binding]; other site
868597008292	active site
868597008293	FMN-binding site [chemical binding]; other site
868597008294	HemK family putative methylases; Region: hemK_fam; TIGR00536
868597008295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597008296	S-adenosylmethionine binding site [chemical binding]; other site
868597008297	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
868597008298	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
868597008299	Cu(I) binding site [ion binding]; other site
868597008300	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
868597008301	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
868597008302	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
868597008303	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597008304	catalytic residue [active]
868597008305	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
868597008306	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
868597008307	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
868597008308	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
868597008309	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
868597008310	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
868597008311	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
868597008312	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
868597008313	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
868597008314	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597008315	FeS/SAM binding site; other site
868597008316	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
868597008317	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
868597008318	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
868597008319	Phage tail assembly chaperone; Region: Phage_TAC; pfam06222
868597008320	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
868597008321	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
868597008322	nucleotide binding site/active site [active]
868597008323	HIT family signature motif; other site
868597008324	catalytic residue [active]
868597008325	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
868597008326	trimer interface [polypeptide binding]; other site
868597008327	active site
868597008328	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
868597008329	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
868597008330	Walker A motif; other site
868597008331	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
868597008332	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597008333	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597008334	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597008335	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597008336	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
868597008337	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597008338	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
868597008339	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
868597008340	active site
868597008341	Zn binding site [ion binding]; other site
868597008342	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
868597008343	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
868597008344	active site
868597008345	Zn binding site [ion binding]; other site
868597008346	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
868597008347	dimer interface [polypeptide binding]; other site
868597008348	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
868597008349	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
868597008350	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
868597008351	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
868597008352	active site
868597008353	DNA binding site [nucleotide binding]
868597008354	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
868597008355	EamA-like transporter family; Region: EamA; pfam00892
868597008356	EamA-like transporter family; Region: EamA; pfam00892
868597008357	glutathione reductase; Validated; Region: PRK06116
868597008358	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
868597008359	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
868597008360	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
868597008361	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
868597008362	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
868597008363	Predicted membrane protein [Function unknown]; Region: COG2311
868597008364	Protein of unknown function (DUF418); Region: DUF418; cl12135
868597008365	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
868597008366	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
868597008367	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
868597008368	NlpC/P60 family; Region: NLPC_P60; pfam00877
868597008369	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
868597008370	NlpC/P60 family; Region: NLPC_P60; pfam00877
868597008371	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
868597008372	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
868597008373	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
868597008374	Alkaline phosphatase homologues; Region: alkPPc; smart00098
868597008375	active site
868597008376	dimer interface [polypeptide binding]; other site
868597008377	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
868597008378	Ligand Binding Site [chemical binding]; other site
868597008379	TilS substrate binding domain; Region: TilS; pfam09179
868597008380	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
868597008381	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
868597008382	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
868597008383	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
868597008384	substrate binding pocket [chemical binding]; other site
868597008385	chain length determination region; other site
868597008386	substrate-Mg2+ binding site; other site
868597008387	catalytic residues [active]
868597008388	aspartate-rich region 1; other site
868597008389	active site lid residues [active]
868597008390	aspartate-rich region 2; other site
868597008391	Tic20-like protein; Region: Tic20; pfam09685
868597008392	peptidase PmbA; Provisional; Region: PRK11040
868597008393	hypothetical protein; Provisional; Region: PRK05255
868597008394	protease TldD; Provisional; Region: tldD; PRK10735
868597008395	TIGR02099 family protein; Region: TIGR02099
868597008396	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
868597008397	ribonuclease G; Provisional; Region: PRK11712
868597008398	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
868597008399	homodimer interface [polypeptide binding]; other site
868597008400	oligonucleotide binding site [chemical binding]; other site
868597008401	Maf-like protein; Region: Maf; pfam02545
868597008402	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
868597008403	active site
868597008404	dimer interface [polypeptide binding]; other site
868597008405	Uncharacterized conserved protein [Function unknown]; Region: COG2968
868597008406	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
868597008407	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597008408	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
868597008409	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
868597008410	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597008411	ligand-binding site [chemical binding]; other site
868597008412	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597008413	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
868597008414	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597008415	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
868597008416	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
868597008417	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
868597008418	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
868597008419	active site
868597008420	(T/H)XGH motif; other site
868597008421	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
868597008422	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
868597008423	Lipopolysaccharide-assembly; Region: LptE; cl01125
868597008424	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
868597008425	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
868597008426	HIGH motif; other site
868597008427	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
868597008428	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
868597008429	active site
868597008430	KMSKS motif; other site
868597008431	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
868597008432	tRNA binding surface [nucleotide binding]; other site
868597008433	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
868597008434	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
868597008435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
868597008436	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
868597008437	FecR protein; Region: FecR; pfam04773
868597008438	CHASE2 domain; Region: CHASE2; pfam05226
868597008439	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597008440	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597008441	metal binding site [ion binding]; metal-binding site
868597008442	active site
868597008443	I-site; other site
868597008444	Uncharacterized conserved protein [Function unknown]; Region: COG2928
868597008445	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
868597008446	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
868597008447	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
868597008448	Beta-lactamase; Region: Beta-lactamase; pfam00144
868597008449	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
868597008450	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597008451	putative metal binding site [ion binding]; other site
868597008452	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
868597008453	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
868597008454	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
868597008455	active site
868597008456	HIGH motif; other site
868597008457	KMSKS motif; other site
868597008458	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
868597008459	anticodon binding site; other site
868597008460	tRNA binding surface [nucleotide binding]; other site
868597008461	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
868597008462	dimer interface [polypeptide binding]; other site
868597008463	putative tRNA-binding site [nucleotide binding]; other site
868597008464	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
868597008465	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
868597008466	ferredoxin; Provisional; Region: PRK08764
868597008467	Putative Fe-S cluster; Region: FeS; pfam04060
868597008468	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
868597008469	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
868597008470	homotrimer interaction site [polypeptide binding]; other site
868597008471	putative active site [active]
868597008472	Predicted integral membrane protein [Function unknown]; Region: COG0392
868597008473	Uncharacterized conserved protein [Function unknown]; Region: COG2898
868597008474	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
868597008475	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
868597008476	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
868597008477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
868597008478	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
868597008479	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
868597008480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597008481	binding surface
868597008482	TPR motif; other site
868597008483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597008484	binding surface
868597008485	TPR motif; other site
868597008486	TPR repeat; Region: TPR_11; pfam13414
868597008487	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
868597008488	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
868597008489	PhnA protein; Region: PhnA; pfam03831
868597008490	putative chaperone; Provisional; Region: PRK11678
868597008491	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
868597008492	nucleotide binding site [chemical binding]; other site
868597008493	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
868597008494	putative NEF/HSP70 interaction site [polypeptide binding]; other site
868597008495	nucleotide binding site [chemical binding]; other site
868597008496	SBD interface [polypeptide binding]; other site
868597008497	Flagellin N-methylase; Region: FliB; pfam03692
868597008498	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
868597008499	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
868597008500	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
868597008501	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597008502	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597008503	DNA binding residues [nucleotide binding]
868597008504	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
868597008505	Mechanosensitive ion channel; Region: MS_channel; pfam00924
868597008506	hypothetical protein; Provisional; Region: PRK11019
868597008507	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
868597008508	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
868597008509	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
868597008510	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597008511	RNA binding surface [nucleotide binding]; other site
868597008512	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
868597008513	active site
868597008514	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
868597008515	PLD-like domain; Region: PLDc_2; pfam13091
868597008516	putative active site [active]
868597008517	catalytic site [active]
868597008518	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
868597008519	PLD-like domain; Region: PLDc_2; pfam13091
868597008520	putative active site [active]
868597008521	catalytic site [active]
868597008522	HDOD domain; Region: HDOD; pfam08668
868597008523	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
868597008524	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
868597008525	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
868597008526	NAD binding site [chemical binding]; other site
868597008527	Phe binding site; other site
868597008528	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
868597008529	catalytic triad [active]
868597008530	putative active site [active]
868597008531	Autotransporter beta-domain; Region: Autotransporter; pfam03797
868597008532	putative acyltransferase; Provisional; Region: PRK05790
868597008533	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
868597008534	dimer interface [polypeptide binding]; other site
868597008535	active site
868597008536	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
868597008537	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
868597008538	active site
868597008539	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
868597008540	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
868597008541	ATP-dependent DNA ligase; Validated; Region: PRK09247
868597008542	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
868597008543	active site
868597008544	DNA binding site [nucleotide binding]
868597008545	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
868597008546	DNA binding site [nucleotide binding]
868597008547	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
868597008548	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
868597008549	ATP binding site [chemical binding]; other site
868597008550	putative Mg++ binding site [ion binding]; other site
868597008551	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597008552	nucleotide binding region [chemical binding]; other site
868597008553	DEAD/H associated; Region: DEAD_assoc; pfam08494
868597008554	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
868597008555	putative active site [active]
868597008556	putative metal binding site [ion binding]; other site
868597008557	hypothetical protein; Provisional; Region: PRK07236
868597008558	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
868597008559	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
868597008560	DNA-binding site [nucleotide binding]; DNA binding site
868597008561	RNA-binding motif; other site
868597008562	5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136
868597008563	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
868597008564	active site
868597008565	beta-hexosaminidase; Provisional; Region: PRK05337
868597008566	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
868597008567	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
868597008568	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
868597008569	catalytic residues [active]
868597008570	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
868597008571	putative active site [active]
868597008572	putative metal binding residues [ion binding]; other site
868597008573	signature motif; other site
868597008574	putative dimer interface [polypeptide binding]; other site
868597008575	putative phosphate binding site [ion binding]; other site
868597008576	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
868597008577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597008578	S-adenosylmethionine binding site [chemical binding]; other site
868597008579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597008580	Response regulator receiver domain; Region: Response_reg; pfam00072
868597008581	active site
868597008582	phosphorylation site [posttranslational modification]
868597008583	intermolecular recognition site; other site
868597008584	dimerization interface [polypeptide binding]; other site
868597008585	Hpt domain; Region: Hpt; pfam01627
868597008586	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
868597008587	Recombination protein O N terminal; Region: RecO_N; pfam11967
868597008588	Recombination protein O C terminal; Region: RecO_C; pfam02565
868597008589	GTPase Era; Reviewed; Region: era; PRK00089
868597008590	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
868597008591	G1 box; other site
868597008592	GTP/Mg2+ binding site [chemical binding]; other site
868597008593	Switch I region; other site
868597008594	G2 box; other site
868597008595	Switch II region; other site
868597008596	G3 box; other site
868597008597	G4 box; other site
868597008598	G5 box; other site
868597008599	KH domain; Region: KH_2; pfam07650
868597008600	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
868597008601	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
868597008602	dimerization interface [polypeptide binding]; other site
868597008603	active site
868597008604	metal binding site [ion binding]; metal-binding site
868597008605	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
868597008606	dsRNA binding site [nucleotide binding]; other site
868597008607	signal peptidase I; Provisional; Region: PRK10861
868597008608	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
868597008609	Catalytic site [active]
868597008610	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
868597008611	GTP-binding protein LepA; Provisional; Region: PRK05433
868597008612	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
868597008613	G1 box; other site
868597008614	putative GEF interaction site [polypeptide binding]; other site
868597008615	GTP/Mg2+ binding site [chemical binding]; other site
868597008616	Switch I region; other site
868597008617	G2 box; other site
868597008618	G3 box; other site
868597008619	Switch II region; other site
868597008620	G4 box; other site
868597008621	G5 box; other site
868597008622	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
868597008623	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
868597008624	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
868597008625	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
868597008626	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
868597008627	active site
868597008628	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
868597008629	protein binding site [polypeptide binding]; other site
868597008630	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
868597008631	protein binding site [polypeptide binding]; other site
868597008632	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
868597008633	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
868597008634	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597008635	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597008636	DNA binding residues [nucleotide binding]
868597008637	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
868597008638	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
868597008639	substrate binding site [chemical binding]; other site
868597008640	oxyanion hole (OAH) forming residues; other site
868597008641	trimer interface [polypeptide binding]; other site
868597008642	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
868597008643	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
868597008644	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
868597008645	Pirin-related protein [General function prediction only]; Region: COG1741
868597008646	Pirin; Region: Pirin; pfam02678
868597008647	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
868597008648	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
868597008649	amphipathic channel; other site
868597008650	Asn-Pro-Ala signature motifs; other site
868597008651	Pirin-related protein [General function prediction only]; Region: COG1741
868597008652	Pirin; Region: Pirin; pfam02678
868597008653	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
868597008654	carbon starvation protein A; Provisional; Region: PRK15015
868597008655	Carbon starvation protein CstA; Region: CstA; pfam02554
868597008656	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
868597008657	Protein of unknown function (DUF466); Region: DUF466; pfam04328
868597008658	Protein of unknown function (DUF819); Region: DUF819; cl02317
868597008659	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
868597008660	active site
868597008661	metal binding site [ion binding]; metal-binding site
868597008662	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597008663	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597008664	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
868597008665	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597008666	dimer interface [polypeptide binding]; other site
868597008667	phosphorylation site [posttranslational modification]
868597008668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597008669	ATP binding site [chemical binding]; other site
868597008670	Mg2+ binding site [ion binding]; other site
868597008671	G-X-G motif; other site
868597008672	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597008673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597008674	active site
868597008675	phosphorylation site [posttranslational modification]
868597008676	intermolecular recognition site; other site
868597008677	dimerization interface [polypeptide binding]; other site
868597008678	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597008679	DNA binding site [nucleotide binding]
868597008680	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
868597008681	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
868597008682	active site
868597008683	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
868597008684	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
868597008685	Sulfatase; Region: Sulfatase; pfam00884
868597008686	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
868597008687	active site
868597008688	Zn binding site [ion binding]; other site
868597008689	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
868597008690	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
868597008691	FAD binding pocket [chemical binding]; other site
868597008692	FAD binding motif [chemical binding]; other site
868597008693	phosphate binding motif [ion binding]; other site
868597008694	NAD binding pocket [chemical binding]; other site
868597008695	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
868597008696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597008697	putative substrate translocation pore; other site
868597008698	glycine dehydrogenase; Provisional; Region: PRK05367
868597008699	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
868597008700	tetramer interface [polypeptide binding]; other site
868597008701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597008702	catalytic residue [active]
868597008703	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
868597008704	tetramer interface [polypeptide binding]; other site
868597008705	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597008706	catalytic residue [active]
868597008707	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
868597008708	dimer interface [polypeptide binding]; other site
868597008709	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
868597008710	PAS fold; Region: PAS_4; pfam08448
868597008711	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597008712	putative active site [active]
868597008713	heme pocket [chemical binding]; other site
868597008714	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597008715	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597008716	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
868597008717	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
868597008718	dimerization interface [polypeptide binding]; other site
868597008719	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
868597008720	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597008721	dimer interface [polypeptide binding]; other site
868597008722	putative CheW interface [polypeptide binding]; other site
868597008723	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
868597008724	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
868597008725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
868597008726	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
868597008727	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
868597008728	Peptidase family M23; Region: Peptidase_M23; pfam01551
868597008729	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
868597008730	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
868597008731	GDP-binding site [chemical binding]; other site
868597008732	ACT binding site; other site
868597008733	IMP binding site; other site
868597008734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
868597008735	FtsH protease regulator HflC; Provisional; Region: PRK11029
868597008736	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
868597008737	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
868597008738	HflK protein; Region: hflK; TIGR01933
868597008739	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
868597008740	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
868597008741	NADP binding site [chemical binding]; other site
868597008742	dimer interface [polypeptide binding]; other site
868597008743	Response regulator receiver domain; Region: Response_reg; pfam00072
868597008744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597008745	active site
868597008746	phosphorylation site [posttranslational modification]
868597008747	intermolecular recognition site; other site
868597008748	dimerization interface [polypeptide binding]; other site
868597008749	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
868597008750	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
868597008751	HSP70 interaction site [polypeptide binding]; other site
868597008752	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
868597008753	substrate binding site [polypeptide binding]; other site
868597008754	dimer interface [polypeptide binding]; other site
868597008755	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
868597008756	catalytic triad [active]
868597008757	dimer interface [polypeptide binding]; other site
868597008758	Ferritin-like domain; Region: Ferritin; pfam00210
868597008759	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
868597008760	dinuclear metal binding motif [ion binding]; other site
868597008761	penicillin-binding protein 1C; Provisional; Region: PRK11240
868597008762	Transglycosylase; Region: Transgly; pfam00912
868597008763	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
868597008764	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
868597008765	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
868597008766	MG2 domain; Region: A2M_N; pfam01835
868597008767	Alpha-2-macroglobulin family; Region: A2M; pfam00207
868597008768	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
868597008769	surface patch; other site
868597008770	thioester region; other site
868597008771	specificity defining residues; other site
868597008772	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
868597008773	2-methylcitrate dehydratase; Region: prpD; TIGR02330
868597008774	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
868597008775	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
868597008776	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
868597008777	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
868597008778	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
868597008779	substrate binding site [chemical binding]; other site
868597008780	ligand binding site [chemical binding]; other site
868597008781	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
868597008782	substrate binding site [chemical binding]; other site
868597008783	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
868597008784	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
868597008785	dimer interface [polypeptide binding]; other site
868597008786	active site
868597008787	citrylCoA binding site [chemical binding]; other site
868597008788	oxalacetate/citrate binding site [chemical binding]; other site
868597008789	coenzyme A binding site [chemical binding]; other site
868597008790	catalytic triad [active]
868597008791	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
868597008792	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
868597008793	tetramer interface [polypeptide binding]; other site
868597008794	active site
868597008795	Mg2+/Mn2+ binding site [ion binding]; other site
868597008796	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
868597008797	Propionate catabolism activator; Region: PrpR_N; pfam06506
868597008798	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597008799	Walker A motif; other site
868597008800	ATP binding site [chemical binding]; other site
868597008801	Walker B motif; other site
868597008802	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
868597008803	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
868597008804	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
868597008805	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
868597008806	D-glycerate 3-kinase; Region: PLN02796
868597008807	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
868597008808	Dodecin; Region: Dodecin; pfam07311
868597008809	shikimate kinase; Reviewed; Region: aroK; PRK00131
868597008810	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
868597008811	ADP binding site [chemical binding]; other site
868597008812	magnesium binding site [ion binding]; other site
868597008813	putative shikimate binding site; other site
868597008814	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
868597008815	active site
868597008816	dimer interface [polypeptide binding]; other site
868597008817	metal binding site [ion binding]; metal-binding site
868597008818	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
868597008819	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
868597008820	substrate binding site [chemical binding]; other site
868597008821	active site
868597008822	putative transporter; Provisional; Region: PRK10504
868597008823	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597008824	putative substrate translocation pore; other site
868597008825	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
868597008826	Two component regulator propeller; Region: Reg_prop; pfam07494
868597008827	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
868597008828	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597008829	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597008830	dimer interface [polypeptide binding]; other site
868597008831	phosphorylation site [posttranslational modification]
868597008832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597008833	ATP binding site [chemical binding]; other site
868597008834	Mg2+ binding site [ion binding]; other site
868597008835	G-X-G motif; other site
868597008836	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597008837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597008838	active site
868597008839	phosphorylation site [posttranslational modification]
868597008840	intermolecular recognition site; other site
868597008841	dimerization interface [polypeptide binding]; other site
868597008842	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
868597008843	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
868597008844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597008845	dimer interface [polypeptide binding]; other site
868597008846	phosphorylation site [posttranslational modification]
868597008847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597008848	ATP binding site [chemical binding]; other site
868597008849	Mg2+ binding site [ion binding]; other site
868597008850	G-X-G motif; other site
868597008851	Response regulator receiver domain; Region: Response_reg; pfam00072
868597008852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597008853	active site
868597008854	phosphorylation site [posttranslational modification]
868597008855	intermolecular recognition site; other site
868597008856	dimerization interface [polypeptide binding]; other site
868597008857	Uncharacterized conserved protein [Function unknown]; Region: COG2353
868597008858	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
868597008859	Uncharacterized conserved protein [Function unknown]; Region: COG2353
868597008860	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
868597008861	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
868597008862	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
868597008863	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
868597008864	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
868597008865	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
868597008866	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
868597008867	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
868597008868	cystathionine gamma-synthase; Provisional; Region: PRK08776
868597008869	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
868597008870	homodimer interface [polypeptide binding]; other site
868597008871	substrate-cofactor binding pocket; other site
868597008872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597008873	catalytic residue [active]
868597008874	homoserine O-acetyltransferase; Provisional; Region: PRK08775
868597008875	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
868597008876	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
868597008877	Peptidase family M23; Region: Peptidase_M23; pfam01551
868597008878	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
868597008879	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
868597008880	G1 box; other site
868597008881	putative GEF interaction site [polypeptide binding]; other site
868597008882	GTP/Mg2+ binding site [chemical binding]; other site
868597008883	Switch I region; other site
868597008884	G2 box; other site
868597008885	G3 box; other site
868597008886	Switch II region; other site
868597008887	G4 box; other site
868597008888	G5 box; other site
868597008889	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
868597008890	Haemolysin-III related; Region: HlyIII; cl03831
868597008891	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
868597008892	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
868597008893	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
868597008894	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
868597008895	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
868597008896	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
868597008897	Ligand binding site; other site
868597008898	Putative Catalytic site; other site
868597008899	DXD motif; other site
868597008900	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
868597008901	Transglycosylase; Region: Transgly; cl17702
868597008902	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
868597008903	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
868597008904	dimerization interface [polypeptide binding]; other site
868597008905	domain crossover interface; other site
868597008906	redox-dependent activation switch; other site
868597008907	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
868597008908	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597008909	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597008910	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597008911	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597008912	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597008913	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
868597008914	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
868597008915	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
868597008916	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
868597008917	active site
868597008918	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
868597008919	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
868597008920	CoenzymeA binding site [chemical binding]; other site
868597008921	subunit interaction site [polypeptide binding]; other site
868597008922	PHB binding site; other site
868597008923	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
868597008924	TLC ATP/ADP transporter; Region: TLC; cl03940
868597008925	Major Facilitator Superfamily; Region: MFS_1; pfam07690
868597008926	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
868597008927	Beta-lactamase; Region: Beta-lactamase; pfam00144
868597008928	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
868597008929	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597008930	NAD(P) binding site [chemical binding]; other site
868597008931	active site
868597008932	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597008933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597008934	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
868597008935	putative effector binding pocket; other site
868597008936	putative dimerization interface [polypeptide binding]; other site
868597008937	glycine cleavage system protein H; Provisional; Region: PRK13380
868597008938	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
868597008939	lipoyl attachment site [posttranslational modification]; other site
868597008940	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
868597008941	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
868597008942	Protein of unknown function (DUF962); Region: DUF962; pfam06127
868597008943	hypothetical protein; Provisional; Region: PRK02237
868597008944	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
868597008945	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
868597008946	homodimer interface [polypeptide binding]; other site
868597008947	metal binding site [ion binding]; metal-binding site
868597008948	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
868597008949	homodimer interface [polypeptide binding]; other site
868597008950	active site
868597008951	putative chemical substrate binding site [chemical binding]; other site
868597008952	metal binding site [ion binding]; metal-binding site
868597008953	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
868597008954	active site
868597008955	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
868597008956	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
868597008957	dimer interface [polypeptide binding]; other site
868597008958	ADP-ribose binding site [chemical binding]; other site
868597008959	active site
868597008960	nudix motif; other site
868597008961	metal binding site [ion binding]; metal-binding site
868597008962	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK08742
868597008963	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
868597008964	inhibitor-cofactor binding pocket; inhibition site
868597008965	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597008966	catalytic residue [active]
868597008967	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
868597008968	CheW-like domain; Region: CheW; pfam01584
868597008969	CheB methylesterase; Region: CheB_methylest; pfam01339
868597008970	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
868597008971	putative binding surface; other site
868597008972	active site
868597008973	Hpt domain; Region: Hpt; pfam01627
868597008974	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
868597008975	putative binding surface; other site
868597008976	active site
868597008977	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
868597008978	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
868597008979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597008980	ATP binding site [chemical binding]; other site
868597008981	Mg2+ binding site [ion binding]; other site
868597008982	G-X-G motif; other site
868597008983	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
868597008984	Response regulator receiver domain; Region: Response_reg; pfam00072
868597008985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597008986	active site
868597008987	phosphorylation site [posttranslational modification]
868597008988	intermolecular recognition site; other site
868597008989	dimerization interface [polypeptide binding]; other site
868597008990	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
868597008991	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597008992	dimer interface [polypeptide binding]; other site
868597008993	putative CheW interface [polypeptide binding]; other site
868597008994	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
868597008995	Response regulator receiver domain; Region: Response_reg; pfam00072
868597008996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597008997	active site
868597008998	phosphorylation site [posttranslational modification]
868597008999	intermolecular recognition site; other site
868597009000	dimerization interface [polypeptide binding]; other site
868597009001	Response regulator receiver domain; Region: Response_reg; pfam00072
868597009002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597009003	active site
868597009004	phosphorylation site [posttranslational modification]
868597009005	intermolecular recognition site; other site
868597009006	dimerization interface [polypeptide binding]; other site
868597009007	glutathione synthetase; Provisional; Region: PRK05246
868597009008	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
868597009009	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
868597009010	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
868597009011	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597009012	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
868597009013	Glycoprotease family; Region: Peptidase_M22; pfam00814
868597009014	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
868597009015	DEAD/DEAH box helicase; Region: DEAD; pfam00270
868597009016	ATP binding site [chemical binding]; other site
868597009017	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
868597009018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
868597009019	Transposase; Region: HTH_Tnp_1; cl17663
868597009020	putative transposase OrfB; Reviewed; Region: PHA02517
868597009021	HTH-like domain; Region: HTH_21; pfam13276
868597009022	Integrase core domain; Region: rve; pfam00665
868597009023	Integrase core domain; Region: rve_3; pfam13683
868597009024	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
868597009025	Transglycosylase; Region: Transgly; pfam00912
868597009026	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
868597009027	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
868597009028	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
868597009029	Probable Catalytic site; other site
868597009030	metal-binding site
868597009031	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
868597009032	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
868597009033	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
868597009034	HD domain; Region: HD_4; pfam13328
868597009035	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
868597009036	synthetase active site [active]
868597009037	NTP binding site [chemical binding]; other site
868597009038	metal binding site [ion binding]; metal-binding site
868597009039	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
868597009040	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
868597009041	DEAD-like helicases superfamily; Region: DEXDc; smart00487
868597009042	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
868597009043	ATP binding site [chemical binding]; other site
868597009044	putative Mg++ binding site [ion binding]; other site
868597009045	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597009046	nucleotide binding region [chemical binding]; other site
868597009047	ATP-binding site [chemical binding]; other site
868597009048	Helicase associated domain (HA2); Region: HA2; pfam04408
868597009049	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
868597009050	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
868597009051	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
868597009052	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
868597009053	dimerization interface [polypeptide binding]; other site
868597009054	DPS ferroxidase diiron center [ion binding]; other site
868597009055	ion pore; other site
868597009056	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
868597009057	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
868597009058	ATP binding site [chemical binding]; other site
868597009059	putative Mg++ binding site [ion binding]; other site
868597009060	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597009061	nucleotide binding region [chemical binding]; other site
868597009062	ATP-binding site [chemical binding]; other site
868597009063	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
868597009064	HRDC domain; Region: HRDC; pfam00570
868597009065	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
868597009066	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
868597009067	Multicopper oxidase; Region: Cu-oxidase; pfam00394
868597009068	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
868597009069	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
868597009070	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
868597009071	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597009072	Coenzyme A binding pocket [chemical binding]; other site
868597009073	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
868597009074	Response regulator receiver domain; Region: Response_reg; pfam00072
868597009075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597009076	active site
868597009077	phosphorylation site [posttranslational modification]
868597009078	intermolecular recognition site; other site
868597009079	dimerization interface [polypeptide binding]; other site
868597009080	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
868597009081	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
868597009082	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
868597009083	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
868597009084	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
868597009085	Ligand Binding Site [chemical binding]; other site
868597009086	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
868597009087	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597009088	FeS/SAM binding site; other site
868597009089	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
868597009090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597009091	binding surface
868597009092	TPR motif; other site
868597009093	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
868597009094	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
868597009095	ligand binding site [chemical binding]; other site
868597009096	translocation protein TolB; Provisional; Region: tolB; PRK04922
868597009097	TolB amino-terminal domain; Region: TolB_N; pfam04052
868597009098	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
868597009099	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
868597009100	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
868597009101	TolA protein; Region: tolA_full; TIGR02794
868597009102	TonB C terminal; Region: TonB_2; pfam13103
868597009103	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
868597009104	TolR protein; Region: tolR; TIGR02801
868597009105	TolQ protein; Region: tolQ; TIGR02796
868597009106	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
868597009107	active site
868597009108	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
868597009109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597009110	Walker A motif; other site
868597009111	ATP binding site [chemical binding]; other site
868597009112	Walker B motif; other site
868597009113	arginine finger; other site
868597009114	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
868597009115	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
868597009116	potassium uptake protein; Region: kup; TIGR00794
868597009117	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
868597009118	RuvA N terminal domain; Region: RuvA_N; pfam01330
868597009119	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
868597009120	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
868597009121	active site
868597009122	putative DNA-binding cleft [nucleotide binding]; other site
868597009123	dimer interface [polypeptide binding]; other site
868597009124	hypothetical protein; Validated; Region: PRK00110
868597009125	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
868597009126	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597009127	Coenzyme A binding pocket [chemical binding]; other site
868597009128	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
868597009129	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
868597009130	dimer interface [polypeptide binding]; other site
868597009131	anticodon binding site; other site
868597009132	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
868597009133	homodimer interface [polypeptide binding]; other site
868597009134	motif 1; other site
868597009135	active site
868597009136	motif 2; other site
868597009137	GAD domain; Region: GAD; pfam02938
868597009138	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
868597009139	motif 3; other site
868597009140	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
868597009141	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
868597009142	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
868597009143	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
868597009144	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
868597009145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597009146	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597009147	dimerization interface [polypeptide binding]; other site
868597009148	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
868597009149	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
868597009150	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
868597009151	ABC transporter; Region: ABC_tran_2; pfam12848
868597009152	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
868597009153	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597009154	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597009155	N-terminal plug; other site
868597009156	ligand-binding site [chemical binding]; other site
868597009157	putative cation:proton antiport protein; Provisional; Region: PRK10669
868597009158	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
868597009159	TrkA-N domain; Region: TrkA_N; pfam02254
868597009160	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
868597009161	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
868597009162	homodimer interface [polypeptide binding]; other site
868597009163	substrate-cofactor binding pocket; other site
868597009164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597009165	catalytic residue [active]
868597009166	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597009167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597009168	active site
868597009169	phosphorylation site [posttranslational modification]
868597009170	intermolecular recognition site; other site
868597009171	dimerization interface [polypeptide binding]; other site
868597009172	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597009173	DNA binding site [nucleotide binding]
868597009174	sensor protein RstB; Provisional; Region: PRK10604
868597009175	HAMP domain; Region: HAMP; pfam00672
868597009176	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597009177	dimer interface [polypeptide binding]; other site
868597009178	phosphorylation site [posttranslational modification]
868597009179	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597009180	ATP binding site [chemical binding]; other site
868597009181	Mg2+ binding site [ion binding]; other site
868597009182	G-X-G motif; other site
868597009183	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
868597009184	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
868597009185	Clp amino terminal domain; Region: Clp_N; pfam02861
868597009186	Clp amino terminal domain; Region: Clp_N; pfam02861
868597009187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597009188	Walker A motif; other site
868597009189	ATP binding site [chemical binding]; other site
868597009190	Walker B motif; other site
868597009191	arginine finger; other site
868597009192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597009193	Walker A motif; other site
868597009194	ATP binding site [chemical binding]; other site
868597009195	Walker B motif; other site
868597009196	arginine finger; other site
868597009197	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
868597009198	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
868597009199	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
868597009200	glutathione s-transferase; Provisional; Region: PTZ00057
868597009201	GSH binding site (G-site) [chemical binding]; other site
868597009202	C-terminal domain interface [polypeptide binding]; other site
868597009203	dimer interface [polypeptide binding]; other site
868597009204	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
868597009205	N-terminal domain interface [polypeptide binding]; other site
868597009206	substrate binding pocket (H-site) [chemical binding]; other site
868597009207	pyruvate dehydrogenase; Provisional; Region: PRK09124
868597009208	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
868597009209	PYR/PP interface [polypeptide binding]; other site
868597009210	dimer interface [polypeptide binding]; other site
868597009211	tetramer interface [polypeptide binding]; other site
868597009212	TPP binding site [chemical binding]; other site
868597009213	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
868597009214	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
868597009215	TPP-binding site [chemical binding]; other site
868597009216	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
868597009217	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597009218	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597009219	N-terminal plug; other site
868597009220	ligand-binding site [chemical binding]; other site
868597009221	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
868597009222	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
868597009223	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
868597009224	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
868597009225	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
868597009226	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
868597009227	active site
868597009228	homotetramer interface [polypeptide binding]; other site
868597009229	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
868597009230	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
868597009231	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
868597009232	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
868597009233	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
868597009234	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
868597009235	RNA binding surface [nucleotide binding]; other site
868597009236	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
868597009237	active site
868597009238	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
868597009239	Secretory lipase; Region: LIP; pfam03583
868597009240	NAD synthetase; Provisional; Region: PRK13981
868597009241	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
868597009242	multimer interface [polypeptide binding]; other site
868597009243	active site
868597009244	catalytic triad [active]
868597009245	protein interface 1 [polypeptide binding]; other site
868597009246	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
868597009247	homodimer interface [polypeptide binding]; other site
868597009248	NAD binding pocket [chemical binding]; other site
868597009249	ATP binding pocket [chemical binding]; other site
868597009250	Mg binding site [ion binding]; other site
868597009251	active-site loop [active]
868597009252	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
868597009253	CoA binding domain; Region: CoA_binding; smart00881
868597009254	CoA-ligase; Region: Ligase_CoA; pfam00549
868597009255	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
868597009256	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
868597009257	CoA-ligase; Region: Ligase_CoA; pfam00549
868597009258	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
868597009259	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597009260	dimer interface [polypeptide binding]; other site
868597009261	phosphorylation site [posttranslational modification]
868597009262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597009263	ATP binding site [chemical binding]; other site
868597009264	Mg2+ binding site [ion binding]; other site
868597009265	G-X-G motif; other site
868597009266	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
868597009267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597009268	active site
868597009269	phosphorylation site [posttranslational modification]
868597009270	intermolecular recognition site; other site
868597009271	dimerization interface [polypeptide binding]; other site
868597009272	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597009273	Walker A motif; other site
868597009274	ATP binding site [chemical binding]; other site
868597009275	Walker B motif; other site
868597009276	arginine finger; other site
868597009277	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
868597009278	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
868597009279	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
868597009280	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
868597009281	Walker A motif; other site
868597009282	ATP binding site [chemical binding]; other site
868597009283	Walker B motif; other site
868597009284	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
868597009285	Pilin (bacterial filament); Region: Pilin; pfam00114
868597009286	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
868597009287	Pilin (bacterial filament); Region: Pilin; pfam00114
868597009288	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
868597009289	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597009290	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
868597009291	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
868597009292	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
868597009293	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
868597009294	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
868597009295	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
868597009296	CoA-binding site [chemical binding]; other site
868597009297	ATP-binding [chemical binding]; other site
868597009298	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
868597009299	RHS Repeat; Region: RHS_repeat; pfam05593
868597009300	RHS Repeat; Region: RHS_repeat; cl11982
868597009301	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
868597009302	RHS Repeat; Region: RHS_repeat; pfam05593
868597009303	RHS Repeat; Region: RHS_repeat; pfam05593
868597009304	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
868597009305	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597009306	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
868597009307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597009308	dimer interface [polypeptide binding]; other site
868597009309	phosphorylation site [posttranslational modification]
868597009310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597009311	ATP binding site [chemical binding]; other site
868597009312	Mg2+ binding site [ion binding]; other site
868597009313	G-X-G motif; other site
868597009314	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597009315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597009316	active site
868597009317	phosphorylation site [posttranslational modification]
868597009318	intermolecular recognition site; other site
868597009319	dimerization interface [polypeptide binding]; other site
868597009320	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597009321	DNA binding site [nucleotide binding]
868597009322	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
868597009323	ATP-grasp domain; Region: ATP-grasp_4; cl17255
868597009324	Protein of unknown function (DUF805); Region: DUF805; pfam05656
868597009325	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
868597009326	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
868597009327	active site
868597009328	catalytic triad [active]
868597009329	oxyanion hole [active]
868597009330	Autotransporter beta-domain; Region: Autotransporter; cl17461
868597009331	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
868597009332	thiS-thiF/thiG interaction site; other site
868597009333	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
868597009334	ThiS interaction site; other site
868597009335	putative active site [active]
868597009336	tetramer interface [polypeptide binding]; other site
868597009337	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597009338	S-adenosylmethionine binding site [chemical binding]; other site
868597009339	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
868597009340	transmembrane helices; other site
868597009341	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
868597009342	TrkA-C domain; Region: TrkA_C; pfam02080
868597009343	TrkA-C domain; Region: TrkA_C; pfam02080
868597009344	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
868597009345	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
868597009346	iron-sulfur cluster [ion binding]; other site
868597009347	[2Fe-2S] cluster binding site [ion binding]; other site
868597009348	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
868597009349	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
868597009350	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
868597009351	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
868597009352	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
868597009353	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
868597009354	PA/protease or protease-like domain interface [polypeptide binding]; other site
868597009355	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
868597009356	Peptidase family M28; Region: Peptidase_M28; pfam04389
868597009357	metal binding site [ion binding]; metal-binding site
868597009358	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
868597009359	amino acid carrier protein; Region: agcS; TIGR00835
868597009360	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
868597009361	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
868597009362	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
868597009363	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
868597009364	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
868597009365	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
868597009366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
868597009367	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
868597009368	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597009369	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597009370	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
868597009371	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597009372	N-terminal plug; other site
868597009373	ligand-binding site [chemical binding]; other site
868597009374	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680
868597009375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597009376	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
868597009377	dimerization interface [polypeptide binding]; other site
868597009378	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
868597009379	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
868597009380	dimer interface [polypeptide binding]; other site
868597009381	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597009382	catalytic residue [active]
868597009383	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
868597009384	putative ADP-ribose binding site [chemical binding]; other site
868597009385	putative active site [active]
868597009386	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
868597009387	active site
868597009388	intersubunit interface [polypeptide binding]; other site
868597009389	catalytic residue [active]
868597009390	pyruvate kinase; Provisional; Region: PRK05826
868597009391	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
868597009392	domain interfaces; other site
868597009393	active site
868597009394	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
868597009395	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597009396	motif II; other site
868597009397	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
868597009398	Phosphoglycerate kinase; Region: PGK; pfam00162
868597009399	substrate binding site [chemical binding]; other site
868597009400	hinge regions; other site
868597009401	ADP binding site [chemical binding]; other site
868597009402	catalytic site [active]
868597009403	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
868597009404	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
868597009405	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
868597009406	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
868597009407	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
868597009408	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
868597009409	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
868597009410	active site
868597009411	Zn binding site [ion binding]; other site
868597009412	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
868597009413	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
868597009414	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
868597009415	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597009416	Penicillinase repressor; Region: Pencillinase_R; pfam03965
868597009417	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
868597009418	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
868597009419	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
868597009420	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
868597009421	sequence-specific DNA binding site [nucleotide binding]; other site
868597009422	salt bridge; other site
868597009423	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
868597009424	transketolase; Reviewed; Region: PRK12753
868597009425	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
868597009426	TPP-binding site [chemical binding]; other site
868597009427	dimer interface [polypeptide binding]; other site
868597009428	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
868597009429	PYR/PP interface [polypeptide binding]; other site
868597009430	dimer interface [polypeptide binding]; other site
868597009431	TPP binding site [chemical binding]; other site
868597009432	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
868597009433	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
868597009434	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
868597009435	Oxygen tolerance; Region: BatD; pfam13584
868597009436	Oxygen tolerance; Region: BatD; pfam13584
868597009437	von Willebrand factor type A domain; Region: VWA_2; pfam13519
868597009438	Tetratricopeptide repeat; Region: TPR_16; pfam13432
868597009439	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597009440	binding surface
868597009441	TPR motif; other site
868597009442	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
868597009443	metal ion-dependent adhesion site (MIDAS); other site
868597009444	Protein of unknown function DUF58; Region: DUF58; pfam01882
868597009445	MoxR-like ATPases [General function prediction only]; Region: COG0714
868597009446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597009447	Walker A motif; other site
868597009448	ATP binding site [chemical binding]; other site
868597009449	Walker B motif; other site
868597009450	arginine finger; other site
868597009451	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
868597009452	Secretin and TonB N terminus short domain; Region: STN; smart00965
868597009453	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
868597009454	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
868597009455	Pilus assembly protein, PilP; Region: PilP; pfam04351
868597009456	Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167
868597009457	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
868597009458	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
868597009459	Competence protein A; Region: Competence_A; pfam11104
868597009460	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
868597009461	Transglycosylase; Region: Transgly; pfam00912
868597009462	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
868597009463	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
868597009464	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
868597009465	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
868597009466	trimer interface [polypeptide binding]; other site
868597009467	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
868597009468	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
868597009469	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
868597009470	trimer interface [polypeptide binding]; other site
868597009471	YadA-like C-terminal region; Region: YadA; pfam03895
868597009472	putative fimbrial protein TcfA; Provisional; Region: PRK15308
868597009473	CblD like pilus biogenesis initiator; Region: CblD; cl06460
868597009474	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
868597009475	CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449
868597009476	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
868597009477	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
868597009478	dimer interface [polypeptide binding]; other site
868597009479	Citrate synthase; Region: Citrate_synt; pfam00285
868597009480	active site
868597009481	citrylCoA binding site [chemical binding]; other site
868597009482	NADH binding [chemical binding]; other site
868597009483	cationic pore residues; other site
868597009484	oxalacetate/citrate binding site [chemical binding]; other site
868597009485	coenzyme A binding site [chemical binding]; other site
868597009486	catalytic triad [active]
868597009487	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
868597009488	nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans.  Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649
868597009489	active site
868597009490	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
868597009491	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
868597009492	generic binding surface II; other site
868597009493	ssDNA binding site; other site
868597009494	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
868597009495	ATP binding site [chemical binding]; other site
868597009496	putative Mg++ binding site [ion binding]; other site
868597009497	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597009498	nucleotide binding region [chemical binding]; other site
868597009499	ATP-binding site [chemical binding]; other site
868597009500	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
868597009501	homotrimer interaction site [polypeptide binding]; other site
868597009502	putative active site [active]
868597009503	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
868597009504	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
868597009505	Zn2+ binding site [ion binding]; other site
868597009506	Mg2+ binding site [ion binding]; other site
868597009507	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
868597009508	synthetase active site [active]
868597009509	NTP binding site [chemical binding]; other site
868597009510	metal binding site [ion binding]; metal-binding site
868597009511	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
868597009512	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
868597009513	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
868597009514	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
868597009515	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
868597009516	catalytic site [active]
868597009517	G-X2-G-X-G-K; other site
868597009518	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
868597009519	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
868597009520	molybdopterin cofactor binding site; other site
868597009521	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
868597009522	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
868597009523	molybdopterin cofactor binding site; other site
868597009524	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
868597009525	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
868597009526	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
868597009527	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
868597009528	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
868597009529	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
868597009530	selenocysteine synthase; Provisional; Region: PRK04311
868597009531	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
868597009532	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597009533	catalytic residue [active]
868597009534	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
868597009535	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
868597009536	G1 box; other site
868597009537	putative GEF interaction site [polypeptide binding]; other site
868597009538	GTP/Mg2+ binding site [chemical binding]; other site
868597009539	Switch I region; other site
868597009540	G2 box; other site
868597009541	G3 box; other site
868597009542	Switch II region; other site
868597009543	G4 box; other site
868597009544	G5 box; other site
868597009545	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
868597009546	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
868597009547	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
868597009548	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
868597009549	selenophosphate synthetase; Provisional; Region: PRK00943
868597009550	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
868597009551	dimerization interface [polypeptide binding]; other site
868597009552	putative ATP binding site [chemical binding]; other site
868597009553	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597009554	non-specific DNA binding site [nucleotide binding]; other site
868597009555	salt bridge; other site
868597009556	sequence-specific DNA binding site [nucleotide binding]; other site
868597009557	hypothetical protein; Provisional; Region: PRK11820
868597009558	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
868597009559	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
868597009560	ribonuclease PH; Reviewed; Region: rph; PRK00173
868597009561	Ribonuclease PH; Region: RNase_PH_bact; cd11362
868597009562	hexamer interface [polypeptide binding]; other site
868597009563	active site
868597009564	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597009565	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
868597009566	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
868597009567	active site
868597009568	dimerization interface [polypeptide binding]; other site
868597009569	HemN family oxidoreductase; Provisional; Region: PRK05660
868597009570	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597009571	FeS/SAM binding site; other site
868597009572	HemN C-terminal domain; Region: HemN_C; pfam06969
868597009573	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
868597009574	PilZ domain; Region: PilZ; pfam07238
868597009575	proline dipeptidase; Provisional; Region: PRK13607
868597009576	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
868597009577	active site
868597009578	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
868597009579	proline aminopeptidase P II; Provisional; Region: PRK10879
868597009580	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
868597009581	active site
868597009582	hypothetical protein; Validated; Region: PRK04758
868597009583	TIGR02449 family protein; Region: TIGR02449
868597009584	Cell division protein ZapA; Region: ZapA; cl01146
868597009585	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
868597009586	Uncharacterized conserved protein [Function unknown]; Region: COG2947
868597009587	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
868597009588	tetramer (dimer of dimers) interface [polypeptide binding]; other site
868597009589	active site
868597009590	dimer interface [polypeptide binding]; other site
868597009591	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
868597009592	Uncharacterized conserved protein [Function unknown]; Region: COG2912
868597009593	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
868597009594	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597009595	binding surface
868597009596	TPR motif; other site
868597009597	Rubredoxin [Energy production and conversion]; Region: COG1773
868597009598	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
868597009599	iron binding site [ion binding]; other site
868597009600	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
868597009601	thiamine phosphate binding site [chemical binding]; other site
868597009602	active site
868597009603	pyrophosphate binding site [ion binding]; other site
868597009604	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
868597009605	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
868597009606	inhibitor-cofactor binding pocket; inhibition site
868597009607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597009608	catalytic residue [active]
868597009609	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
868597009610	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
868597009611	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597009612	motif II; other site
868597009613	acetylornithine transaminase protein; Provisional; Region: argD; PRK04612
868597009614	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
868597009615	inhibitor-cofactor binding pocket; inhibition site
868597009616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597009617	catalytic residue [active]
868597009618	Ion transport protein; Region: Ion_trans; pfam00520
868597009619	Ion channel; Region: Ion_trans_2; pfam07885
868597009620	Double zinc ribbon; Region: DZR; pfam12773
868597009621	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
868597009622	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
868597009623	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
868597009624	short chain dehydrogenase; Provisional; Region: PRK08278
868597009625	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
868597009626	NAD(P) binding site [chemical binding]; other site
868597009627	homodimer interface [polypeptide binding]; other site
868597009628	active site
868597009629	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
868597009630	serine/threonine protein kinase; Provisional; Region: PRK12274
868597009631	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
868597009632	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
868597009633	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
868597009634	active site
868597009635	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
868597009636	LssY C-terminus; Region: LssY_C; pfam14067
868597009637	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
868597009638	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
868597009639	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
868597009640	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
868597009641	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
868597009642	adenylate kinase; Reviewed; Region: adk; PRK00279
868597009643	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
868597009644	AMP-binding site [chemical binding]; other site
868597009645	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
868597009646	6-phosphofructokinase; Provisional; Region: PRK14072
868597009647	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
868597009648	active site
868597009649	ADP/pyrophosphate binding site [chemical binding]; other site
868597009650	dimerization interface [polypeptide binding]; other site
868597009651	allosteric effector site; other site
868597009652	fructose-1,6-bisphosphate binding site; other site
868597009653	Protein of unknown function, DUF488; Region: DUF488; cl01246
868597009654	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
868597009655	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
868597009656	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
868597009657	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597009658	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
868597009659	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
868597009660	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
868597009661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
868597009662	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
868597009663	heme binding pocket [chemical binding]; other site
868597009664	heme ligand [chemical binding]; other site
868597009665	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
868597009666	Secretin and TonB N terminus short domain; Region: STN; smart00965
868597009667	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597009668	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597009669	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597009670	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
868597009671	FecR protein; Region: FecR; pfam04773
868597009672	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
868597009673	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597009674	DNA binding residues [nucleotide binding]
868597009675	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
868597009676	substrate binding site [chemical binding]; other site
868597009677	metal binding sites [ion binding]; metal-binding site
868597009678	dimer interface [polypeptide binding]; other site
868597009679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
868597009680	active site
868597009681	phosphorylation site [posttranslational modification]
868597009682	intermolecular recognition site; other site
868597009683	HDOD domain; Region: HDOD; pfam08668
868597009684	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
868597009685	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597009686	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597009687	Helix-turn-helix domain; Region: HTH_18; pfam12833
868597009688	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597009689	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597009690	DNA binding site [nucleotide binding]
868597009691	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
868597009692	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
868597009693	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
868597009694	ThiC-associated domain; Region: ThiC-associated; pfam13667
868597009695	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
868597009696	BCCT family transporter; Region: BCCT; pfam02028
868597009697	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
868597009698	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
868597009699	ketol-acid reductoisomerase; Provisional; Region: PRK05479
868597009700	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
868597009701	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
868597009702	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
868597009703	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
868597009704	PYR/PP interface [polypeptide binding]; other site
868597009705	dimer interface [polypeptide binding]; other site
868597009706	TPP binding site [chemical binding]; other site
868597009707	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
868597009708	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
868597009709	TPP-binding site [chemical binding]; other site
868597009710	dimer interface [polypeptide binding]; other site
868597009711	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
868597009712	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
868597009713	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
868597009714	tetramer interface [polypeptide binding]; other site
868597009715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597009716	catalytic residue [active]
868597009717	2-isopropylmalate synthase; Validated; Region: PRK00915
868597009718	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
868597009719	active site
868597009720	catalytic residues [active]
868597009721	metal binding site [ion binding]; metal-binding site
868597009722	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
868597009723	Methyltransferase domain; Region: Methyltransf_23; pfam13489
868597009724	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597009725	S-adenosylmethionine binding site [chemical binding]; other site
868597009726	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
868597009727	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
868597009728	substrate binding site [chemical binding]; other site
868597009729	ligand binding site [chemical binding]; other site
868597009730	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
868597009731	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
868597009732	substrate binding site [chemical binding]; other site
868597009733	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
868597009734	tartrate dehydrogenase; Region: TTC; TIGR02089
868597009735	short chain dehydrogenase; Provisional; Region: PRK12744
868597009736	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597009737	NAD(P) binding site [chemical binding]; other site
868597009738	active site
868597009739	transcriptional regulator; Provisional; Region: PRK10632
868597009740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597009741	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
868597009742	putative effector binding pocket; other site
868597009743	putative dimerization interface [polypeptide binding]; other site
868597009744	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
868597009745	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597009746	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597009747	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597009748	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597009749	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597009750	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
868597009751	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
868597009752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597009753	S-adenosylmethionine binding site [chemical binding]; other site
868597009754	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
868597009755	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
868597009756	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
868597009757	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
868597009758	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
868597009759	putative acyl-acceptor binding pocket; other site
868597009760	Transposase IS200 like; Region: Y1_Tnp; cl00848
868597009761	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
868597009762	O-Antigen ligase; Region: Wzy_C; pfam04932
868597009763	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
868597009764	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
868597009765	Zinc-finger domain; Region: zf-CHCC; cl01821
868597009766	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
868597009767	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
868597009768	Peptidase of plants and bacteria; Region: BSP; pfam04450
868597009769	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
868597009770	Malic enzyme, N-terminal domain; Region: malic; pfam00390
868597009771	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
868597009772	putative NAD(P) binding site [chemical binding]; other site
868597009773	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
868597009774	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
868597009775	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
868597009776	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
868597009777	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
868597009778	PAS domain; Region: PAS; smart00091
868597009779	PAS fold; Region: PAS_7; pfam12860
868597009780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597009781	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597009782	dimer interface [polypeptide binding]; other site
868597009783	phosphorylation site [posttranslational modification]
868597009784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597009785	ATP binding site [chemical binding]; other site
868597009786	Mg2+ binding site [ion binding]; other site
868597009787	G-X-G motif; other site
868597009788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597009789	Response regulator receiver domain; Region: Response_reg; pfam00072
868597009790	active site
868597009791	phosphorylation site [posttranslational modification]
868597009792	intermolecular recognition site; other site
868597009793	dimerization interface [polypeptide binding]; other site
868597009794	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597009795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597009796	active site
868597009797	phosphorylation site [posttranslational modification]
868597009798	intermolecular recognition site; other site
868597009799	dimerization interface [polypeptide binding]; other site
868597009800	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597009801	DNA binding residues [nucleotide binding]
868597009802	dimerization interface [polypeptide binding]; other site
868597009803	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
868597009804	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
868597009805	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
868597009806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597009807	dimer interface [polypeptide binding]; other site
868597009808	phosphorylation site [posttranslational modification]
868597009809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597009810	ATP binding site [chemical binding]; other site
868597009811	Mg2+ binding site [ion binding]; other site
868597009812	G-X-G motif; other site
868597009813	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
868597009814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597009815	active site
868597009816	phosphorylation site [posttranslational modification]
868597009817	intermolecular recognition site; other site
868597009818	dimerization interface [polypeptide binding]; other site
868597009819	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597009820	DNA binding site [nucleotide binding]
868597009821	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
868597009822	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
868597009823	Citrate transporter; Region: CitMHS; pfam03600
868597009824	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
868597009825	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597009826	NAD(P) binding site [chemical binding]; other site
868597009827	active site
868597009828	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
868597009829	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597009830	N-terminal plug; other site
868597009831	ligand-binding site [chemical binding]; other site
868597009832	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
868597009833	Predicted GTPases [General function prediction only]; Region: COG1162
868597009834	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
868597009835	GTPase/Zn-binding domain interface [polypeptide binding]; other site
868597009836	GTP/Mg2+ binding site [chemical binding]; other site
868597009837	G4 box; other site
868597009838	G5 box; other site
868597009839	G1 box; other site
868597009840	Switch I region; other site
868597009841	G2 box; other site
868597009842	G3 box; other site
868597009843	Switch II region; other site
868597009844	aminotransferase AlaT; Validated; Region: PRK09265
868597009845	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597009846	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597009847	homodimer interface [polypeptide binding]; other site
868597009848	catalytic residue [active]
868597009849	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
868597009850	active site
868597009851	catalytic triad [active]
868597009852	oxyanion hole [active]
868597009853	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
868597009854	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
868597009855	NodB motif; other site
868597009856	active site
868597009857	catalytic site [active]
868597009858	metal binding site [ion binding]; metal-binding site
868597009859	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
868597009860	putative GSH binding site [chemical binding]; other site
868597009861	catalytic residues [active]
868597009862	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
868597009863	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
868597009864	active site residue [active]
868597009865	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
868597009866	AMP nucleosidase; Provisional; Region: PRK07115
868597009867	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
868597009868	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
868597009869	active site
868597009870	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
868597009871	active site
868597009872	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
868597009873	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
868597009874	putative catalytic residue [active]
868597009875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
868597009876	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
868597009877	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
868597009878	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
868597009879	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
868597009880	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597009881	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597009882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597009883	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
868597009884	putative substrate translocation pore; other site
868597009885	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597009886	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597009887	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
868597009888	putative substrate binding pocket [chemical binding]; other site
868597009889	putative dimerization interface [polypeptide binding]; other site
868597009890	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
868597009891	Ligand Binding Site [chemical binding]; other site
868597009892	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597009893	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597009894	metal binding site [ion binding]; metal-binding site
868597009895	active site
868597009896	I-site; other site
868597009897	S-formylglutathione hydrolase; Region: PLN02442
868597009898	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
868597009899	tRNA pseudouridine synthase C; Region: DUF446; cl01187
868597009900	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
868597009901	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
868597009902	substrate binding site [chemical binding]; other site
868597009903	catalytic Zn binding site [ion binding]; other site
868597009904	NAD binding site [chemical binding]; other site
868597009905	structural Zn binding site [ion binding]; other site
868597009906	dimer interface [polypeptide binding]; other site
868597009907	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
868597009908	putative metal binding site [ion binding]; other site
868597009909	putative homodimer interface [polypeptide binding]; other site
868597009910	putative homotetramer interface [polypeptide binding]; other site
868597009911	putative homodimer-homodimer interface [polypeptide binding]; other site
868597009912	putative allosteric switch controlling residues; other site
868597009913	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597009914	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597009915	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
868597009916	putative effector binding pocket; other site
868597009917	putative dimerization interface [polypeptide binding]; other site
868597009918	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
868597009919	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
868597009920	FMN binding site [chemical binding]; other site
868597009921	active site
868597009922	substrate binding site [chemical binding]; other site
868597009923	catalytic residue [active]
868597009924	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
868597009925	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597009926	active site
868597009927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
868597009928	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597009929	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597009930	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597009931	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
868597009932	putative effector binding pocket; other site
868597009933	putative dimerization interface [polypeptide binding]; other site
868597009934	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
868597009935	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
868597009936	putative NAD(P) binding site [chemical binding]; other site
868597009937	putative substrate binding site [chemical binding]; other site
868597009938	catalytic Zn binding site [ion binding]; other site
868597009939	structural Zn binding site [ion binding]; other site
868597009940	dimer interface [polypeptide binding]; other site
868597009941	glutamate--cysteine ligase; Region: PLN02611
868597009942	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
868597009943	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597009944	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597009945	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
868597009946	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
868597009947	G1 box; other site
868597009948	GTP/Mg2+ binding site [chemical binding]; other site
868597009949	Switch I region; other site
868597009950	G2 box; other site
868597009951	G3 box; other site
868597009952	Switch II region; other site
868597009953	G4 box; other site
868597009954	G5 box; other site
868597009955	Cytochrome c553 [Energy production and conversion]; Region: COG2863
868597009956	Cytochrome c; Region: Cytochrom_C; cl11414
868597009957	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
868597009958	catalytic residues [active]
868597009959	hinge region; other site
868597009960	alpha helical domain; other site
868597009961	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
868597009962	catalytic residues [active]
868597009963	hinge region; other site
868597009964	alpha helical domain; other site
868597009965	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
868597009966	putative catalytic site [active]
868597009967	putative metal binding site [ion binding]; other site
868597009968	putative phosphate binding site [ion binding]; other site
868597009969	threonine and homoserine efflux system; Provisional; Region: PRK10532
868597009970	EamA-like transporter family; Region: EamA; cl17759
868597009971	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
868597009972	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
868597009973	putative DNA binding site [nucleotide binding]; other site
868597009974	putative Zn2+ binding site [ion binding]; other site
868597009975	AsnC family; Region: AsnC_trans_reg; pfam01037
868597009976	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
868597009977	Peptidase family M23; Region: Peptidase_M23; pfam01551
868597009978	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
868597009979	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597009980	N-terminal plug; other site
868597009981	ligand-binding site [chemical binding]; other site
868597009982	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
868597009983	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597009984	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597009985	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
868597009986	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
868597009987	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
868597009988	lytic murein transglycosylase; Provisional; Region: PRK11619
868597009989	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
868597009990	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597009991	catalytic residue [active]
868597009992	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
868597009993	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
868597009994	active site
868597009995	NTP binding site [chemical binding]; other site
868597009996	metal binding triad [ion binding]; metal-binding site
868597009997	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
868597009998	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
868597009999	Zn2+ binding site [ion binding]; other site
868597010000	Mg2+ binding site [ion binding]; other site
868597010001	SseB protein; Region: SseB; cl06279
868597010002	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
868597010003	nucleophilic elbow; other site
868597010004	catalytic triad; other site
868597010005	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
868597010006	Active site serine [active]
868597010007	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
868597010008	Autotransporter beta-domain; Region: Autotransporter; smart00869
868597010009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
868597010010	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
868597010011	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
868597010012	active site
868597010013	dimer interface [polypeptide binding]; other site
868597010014	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
868597010015	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
868597010016	dimer interface [polypeptide binding]; other site
868597010017	active site
868597010018	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
868597010019	dimer interface [polypeptide binding]; other site
868597010020	active site
868597010021	Transcriptional regulators [Transcription]; Region: PurR; COG1609
868597010022	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
868597010023	DNA binding site [nucleotide binding]
868597010024	domain linker motif; other site
868597010025	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
868597010026	putative dimerization interface [polypeptide binding]; other site
868597010027	putative ligand binding site [chemical binding]; other site
868597010028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597010029	Major Facilitator Superfamily; Region: MFS_1; pfam07690
868597010030	putative substrate translocation pore; other site
868597010031	glucose/galactose transporter; Region: gluP; TIGR01272
868597010032	glucokinase; Provisional; Region: PRK12408
868597010033	glucokinase, proteobacterial type; Region: glk; TIGR00749
868597010034	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
868597010035	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597010036	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597010037	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
868597010038	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
868597010039	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
868597010040	active site
868597010041	VanZ like family; Region: VanZ; cl01971
868597010042	Uncharacterized conserved protein [Function unknown]; Region: COG1565
868597010043	pteridine reductase; Provisional; Region: PRK09135
868597010044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597010045	NAD(P) binding site [chemical binding]; other site
868597010046	active site
868597010047	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
868597010048	catalytic center binding site [active]
868597010049	ATP binding site [chemical binding]; other site
868597010050	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
868597010051	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
868597010052	active site
868597010053	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597010054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010055	active site
868597010056	phosphorylation site [posttranslational modification]
868597010057	intermolecular recognition site; other site
868597010058	dimerization interface [polypeptide binding]; other site
868597010059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597010060	ATP binding site [chemical binding]; other site
868597010061	Mg2+ binding site [ion binding]; other site
868597010062	G-X-G motif; other site
868597010063	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597010064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
868597010065	active site
868597010066	phosphorylation site [posttranslational modification]
868597010067	intermolecular recognition site; other site
868597010068	dimerization interface [polypeptide binding]; other site
868597010069	Response regulator receiver domain; Region: Response_reg; pfam00072
868597010070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010071	active site
868597010072	phosphorylation site [posttranslational modification]
868597010073	intermolecular recognition site; other site
868597010074	dimerization interface [polypeptide binding]; other site
868597010075	CHASE3 domain; Region: CHASE3; pfam05227
868597010076	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
868597010077	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597010078	dimer interface [polypeptide binding]; other site
868597010079	phosphorylation site [posttranslational modification]
868597010080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597010081	ATP binding site [chemical binding]; other site
868597010082	Mg2+ binding site [ion binding]; other site
868597010083	G-X-G motif; other site
868597010084	BON domain; Region: BON; pfam04972
868597010085	putative oxidoreductase; Provisional; Region: PRK11579
868597010086	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
868597010087	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
868597010088	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
868597010089	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
868597010090	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
868597010091	carboxy-terminal protease; Provisional; Region: PRK11186
868597010092	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
868597010093	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
868597010094	protein binding site [polypeptide binding]; other site
868597010095	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
868597010096	Catalytic dyad [active]
868597010097	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
868597010098	lipoyl synthase; Provisional; Region: PRK05481
868597010099	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597010100	FeS/SAM binding site; other site
868597010101	lipoate-protein ligase B; Provisional; Region: PRK14342
868597010102	hypothetical protein; Provisional; Region: PRK00907
868597010103	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
868597010104	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
868597010105	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
868597010106	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
868597010107	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
868597010108	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
868597010109	Sporulation related domain; Region: SPOR; pfam05036
868597010110	Transglycosylase SLT domain; Region: SLT_2; pfam13406
868597010111	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
868597010112	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597010113	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
868597010114	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
868597010115	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
868597010116	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
868597010117	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
868597010118	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
868597010119	rod shape-determining protein MreC; Provisional; Region: PRK13922
868597010120	rod shape-determining protein MreC; Region: MreC; pfam04085
868597010121	rod shape-determining protein MreB; Provisional; Region: PRK13927
868597010122	MreB and similar proteins; Region: MreB_like; cd10225
868597010123	nucleotide binding site [chemical binding]; other site
868597010124	Mg binding site [ion binding]; other site
868597010125	putative protofilament interaction site [polypeptide binding]; other site
868597010126	RodZ interaction site [polypeptide binding]; other site
868597010127	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
868597010128	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
868597010129	substrate binding site [chemical binding]; other site
868597010130	ATP binding site [chemical binding]; other site
868597010131	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
868597010132	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597010133	motif II; other site
868597010134	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
868597010135	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
868597010136	active site
868597010137	Zn binding site [ion binding]; other site
868597010138	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
868597010139	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
868597010140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597010141	S-adenosylmethionine binding site [chemical binding]; other site
868597010142	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
868597010143	nucleoside/Zn binding site; other site
868597010144	dimer interface [polypeptide binding]; other site
868597010145	catalytic motif [active]
868597010146	Low affinity iron permease; Region: Iron_permease; pfam04120
868597010147	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
868597010148	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
868597010149	Protein export membrane protein; Region: SecD_SecF; cl14618
868597010150	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597010151	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597010152	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597010153	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
868597010154	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597010155	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
868597010156	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
868597010157	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
868597010158	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
868597010159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597010160	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
868597010161	Walker A motif; other site
868597010162	ATP binding site [chemical binding]; other site
868597010163	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597010164	Walker B motif; other site
868597010165	arginine finger; other site
868597010166	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
868597010167	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
868597010168	active site
868597010169	HslU subunit interaction site [polypeptide binding]; other site
868597010170	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
868597010171	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
868597010172	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
868597010173	active site
868597010174	DNA binding site [nucleotide binding]
868597010175	Int/Topo IB signature motif; other site
868597010176	Protein of unknown function, DUF484; Region: DUF484; cl17449
868597010177	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
868597010178	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
868597010179	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
868597010180	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
868597010181	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
868597010182	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597010183	hypothetical protein; Provisional; Region: PRK08960
868597010184	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597010185	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597010186	homodimer interface [polypeptide binding]; other site
868597010187	catalytic residue [active]
868597010188	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
868597010189	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597010190	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
868597010191	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
868597010192	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597010193	non-specific DNA binding site [nucleotide binding]; other site
868597010194	salt bridge; other site
868597010195	sequence-specific DNA binding site [nucleotide binding]; other site
868597010196	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
868597010197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
868597010198	dimer interface [polypeptide binding]; other site
868597010199	conserved gate region; other site
868597010200	ABC-ATPase subunit interface; other site
868597010201	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
868597010202	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
868597010203	Walker A/P-loop; other site
868597010204	ATP binding site [chemical binding]; other site
868597010205	Q-loop/lid; other site
868597010206	ABC transporter signature motif; other site
868597010207	Walker B; other site
868597010208	D-loop; other site
868597010209	H-loop/switch region; other site
868597010210	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
868597010211	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
868597010212	EamA-like transporter family; Region: EamA; pfam00892
868597010213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
868597010214	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
868597010215	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
868597010216	oxidoreductase; Validated; Region: PRK05717
868597010217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597010218	NAD(P) binding site [chemical binding]; other site
868597010219	active site
868597010220	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
868597010221	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
868597010222	active site
868597010223	Zn binding site [ion binding]; other site
868597010224	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
868597010225	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
868597010226	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597010227	catalytic residue [active]
868597010228	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
868597010229	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597010230	dimer interface [polypeptide binding]; other site
868597010231	active site
868597010232	metal binding site [ion binding]; metal-binding site
868597010233	glutathione binding site [chemical binding]; other site
868597010234	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
868597010235	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597010236	FOG: CBS domain [General function prediction only]; Region: COG0517
868597010237	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
868597010238	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
868597010239	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
868597010240	glutaminase active site [active]
868597010241	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
868597010242	dimer interface [polypeptide binding]; other site
868597010243	active site
868597010244	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
868597010245	dimer interface [polypeptide binding]; other site
868597010246	active site
868597010247	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597010248	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597010249	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597010250	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
868597010251	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
868597010252	Walker A/P-loop; other site
868597010253	ATP binding site [chemical binding]; other site
868597010254	Q-loop/lid; other site
868597010255	ABC transporter signature motif; other site
868597010256	Walker B; other site
868597010257	D-loop; other site
868597010258	H-loop/switch region; other site
868597010259	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597010260	FtsX-like permease family; Region: FtsX; pfam02687
868597010261	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597010262	FtsX-like permease family; Region: FtsX; pfam02687
868597010263	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
868597010264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010265	active site
868597010266	phosphorylation site [posttranslational modification]
868597010267	intermolecular recognition site; other site
868597010268	dimerization interface [polypeptide binding]; other site
868597010269	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597010270	Walker A motif; other site
868597010271	ATP binding site [chemical binding]; other site
868597010272	Walker B motif; other site
868597010273	arginine finger; other site
868597010274	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
868597010275	HAMP domain; Region: HAMP; pfam00672
868597010276	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597010277	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597010278	ATP binding site [chemical binding]; other site
868597010279	Mg2+ binding site [ion binding]; other site
868597010280	G-X-G motif; other site
868597010281	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
868597010282	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
868597010283	Substrate binding site; other site
868597010284	Mg++ binding site; other site
868597010285	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
868597010286	active site
868597010287	substrate binding site [chemical binding]; other site
868597010288	CoA binding site [chemical binding]; other site
868597010289	GtrA-like protein; Region: GtrA; pfam04138
868597010290	Predicted membrane protein [Function unknown]; Region: COG2246
868597010291	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
868597010292	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
868597010293	gamma subunit interface [polypeptide binding]; other site
868597010294	epsilon subunit interface [polypeptide binding]; other site
868597010295	LBP interface [polypeptide binding]; other site
868597010296	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
868597010297	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
868597010298	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
868597010299	alpha subunit interaction interface [polypeptide binding]; other site
868597010300	Walker A motif; other site
868597010301	ATP binding site [chemical binding]; other site
868597010302	Walker B motif; other site
868597010303	inhibitor binding site; inhibition site
868597010304	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
868597010305	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
868597010306	core domain interface [polypeptide binding]; other site
868597010307	delta subunit interface [polypeptide binding]; other site
868597010308	epsilon subunit interface [polypeptide binding]; other site
868597010309	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
868597010310	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
868597010311	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
868597010312	beta subunit interaction interface [polypeptide binding]; other site
868597010313	Walker A motif; other site
868597010314	ATP binding site [chemical binding]; other site
868597010315	Walker B motif; other site
868597010316	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
868597010317	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
868597010318	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
868597010319	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
868597010320	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
868597010321	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
868597010322	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
868597010323	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
868597010324	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
868597010325	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
868597010326	E3 interaction surface; other site
868597010327	lipoyl attachment site [posttranslational modification]; other site
868597010328	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
868597010329	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
868597010330	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
868597010331	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
868597010332	E3 interaction surface; other site
868597010333	lipoyl attachment site [posttranslational modification]; other site
868597010334	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
868597010335	E3 interaction surface; other site
868597010336	lipoyl attachment site [posttranslational modification]; other site
868597010337	e3 binding domain; Region: E3_binding; pfam02817
868597010338	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
868597010339	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
868597010340	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
868597010341	putative active site [active]
868597010342	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
868597010343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
868597010344	Transposase; Region: DEDD_Tnp_IS110; pfam01548
868597010345	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
868597010346	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
868597010347	glycerol kinase; Provisional; Region: glpK; PRK00047
868597010348	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
868597010349	N- and C-terminal domain interface [polypeptide binding]; other site
868597010350	active site
868597010351	MgATP binding site [chemical binding]; other site
868597010352	catalytic site [active]
868597010353	metal binding site [ion binding]; metal-binding site
868597010354	glycerol binding site [chemical binding]; other site
868597010355	homotetramer interface [polypeptide binding]; other site
868597010356	homodimer interface [polypeptide binding]; other site
868597010357	FBP binding site [chemical binding]; other site
868597010358	protein IIAGlc interface [polypeptide binding]; other site
868597010359	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
868597010360	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
868597010361	Predicted transcriptional regulator [Transcription]; Region: COG2378
868597010362	HTH domain; Region: HTH_11; pfam08279
868597010363	WYL domain; Region: WYL; pfam13280
868597010364	Protein of unknown function, DUF481; Region: DUF481; pfam04338
868597010365	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
868597010366	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
868597010367	domain interfaces; other site
868597010368	active site
868597010369	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
868597010370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010371	active site
868597010372	phosphorylation site [posttranslational modification]
868597010373	intermolecular recognition site; other site
868597010374	dimerization interface [polypeptide binding]; other site
868597010375	LytTr DNA-binding domain; Region: LytTR; pfam04397
868597010376	Histidine kinase; Region: His_kinase; pfam06580
868597010377	putative hydrolase; Provisional; Region: PRK11460
868597010378	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
868597010379	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
868597010380	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
868597010381	Ligand binding site; other site
868597010382	DXD motif; other site
868597010383	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
868597010384	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597010385	N-terminal plug; other site
868597010386	ligand-binding site [chemical binding]; other site
868597010387	Cache domain; Region: Cache_1; pfam02743
868597010388	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
868597010389	dimerization interface [polypeptide binding]; other site
868597010390	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597010391	dimer interface [polypeptide binding]; other site
868597010392	putative CheW interface [polypeptide binding]; other site
868597010393	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
868597010394	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597010395	NAD(P) binding site [chemical binding]; other site
868597010396	active site
868597010397	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
868597010398	active site triad [active]
868597010399	MarR family; Region: MarR_2; pfam12802
868597010400	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
868597010401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597010402	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597010403	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597010404	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
868597010405	dimer interface [polypeptide binding]; other site
868597010406	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597010407	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
868597010408	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
868597010409	catalytic triad [active]
868597010410	putative active site [active]
868597010411	Autotransporter beta-domain; Region: Autotransporter; smart00869
868597010412	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
868597010413	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
868597010414	Walker A/P-loop; other site
868597010415	ATP binding site [chemical binding]; other site
868597010416	Q-loop/lid; other site
868597010417	ABC transporter signature motif; other site
868597010418	Walker B; other site
868597010419	D-loop; other site
868597010420	H-loop/switch region; other site
868597010421	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597010422	FtsX-like permease family; Region: FtsX; pfam02687
868597010423	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
868597010424	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
868597010425	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
868597010426	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597010427	Walker A/P-loop; other site
868597010428	ATP binding site [chemical binding]; other site
868597010429	Q-loop/lid; other site
868597010430	ABC transporter signature motif; other site
868597010431	Walker B; other site
868597010432	D-loop; other site
868597010433	H-loop/switch region; other site
868597010434	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
868597010435	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
868597010436	active site
868597010437	ATP binding site [chemical binding]; other site
868597010438	substrate binding site [chemical binding]; other site
868597010439	activation loop (A-loop); other site
868597010440	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
868597010441	active site
868597010442	zinc binding site [ion binding]; other site
868597010443	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597010444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010445	active site
868597010446	phosphorylation site [posttranslational modification]
868597010447	intermolecular recognition site; other site
868597010448	dimerization interface [polypeptide binding]; other site
868597010449	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
868597010450	DNA binding site [nucleotide binding]
868597010451	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
868597010452	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
868597010453	EamA-like transporter family; Region: EamA; pfam00892
868597010454	EamA-like transporter family; Region: EamA; pfam00892
868597010455	Cupin domain; Region: Cupin_2; pfam07883
868597010456	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
868597010457	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597010458	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
868597010459	putative C-terminal domain interface [polypeptide binding]; other site
868597010460	putative GSH binding site (G-site) [chemical binding]; other site
868597010461	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
868597010462	putative dimer interface [polypeptide binding]; other site
868597010463	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
868597010464	dimer interface [polypeptide binding]; other site
868597010465	N-terminal domain interface [polypeptide binding]; other site
868597010466	putative substrate binding pocket (H-site) [chemical binding]; other site
868597010467	H-NS histone family; Region: Histone_HNS; pfam00816
868597010468	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
868597010469	Predicted membrane protein [Function unknown]; Region: COG2259
868597010470	Sensors of blue-light using FAD; Region: BLUF; pfam04940
868597010471	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
868597010472	Fasciclin domain; Region: Fasciclin; pfam02469
868597010473	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
868597010474	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
868597010475	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
868597010476	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
868597010477	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597010478	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
868597010479	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597010480	DNA binding residues [nucleotide binding]
868597010481	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
868597010482	putative active site [active]
868597010483	dimerization interface [polypeptide binding]; other site
868597010484	putative tRNAtyr binding site [nucleotide binding]; other site
868597010485	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
868597010486	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
868597010487	putative acyl-acceptor binding pocket; other site
868597010488	GTP cyclohydrolase; Provisional; Region: PRK08815
868597010489	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
868597010490	dimerization interface [polypeptide binding]; other site
868597010491	active site
868597010492	Bacterial PH domain; Region: DUF304; cl01348
868597010493	Predicted membrane protein [Function unknown]; Region: COG3428
868597010494	Bacterial PH domain; Region: DUF304; pfam03703
868597010495	Bacterial PH domain; Region: DUF304; pfam03703
868597010496	Bacterial PH domain; Region: DUF304; pfam03703
868597010497	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
868597010498	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
868597010499	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
868597010500	putative metal binding site; other site
868597010501	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
868597010502	O-Antigen ligase; Region: Wzy_C; pfam04932
868597010503	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
868597010504	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
868597010505	16S rRNA methyltransferase B; Provisional; Region: PRK10901
868597010506	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
868597010507	putative RNA binding site [nucleotide binding]; other site
868597010508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597010509	S-adenosylmethionine binding site [chemical binding]; other site
868597010510	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
868597010511	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
868597010512	putative active site [active]
868597010513	substrate binding site [chemical binding]; other site
868597010514	putative cosubstrate binding site; other site
868597010515	catalytic site [active]
868597010516	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
868597010517	substrate binding site [chemical binding]; other site
868597010518	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
868597010519	active site
868597010520	catalytic residues [active]
868597010521	metal binding site [ion binding]; metal-binding site
868597010522	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
868597010523	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
868597010524	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
868597010525	DNA protecting protein DprA; Region: dprA; TIGR00732
868597010526	hypothetical protein; Validated; Region: PRK03430
868597010527	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
868597010528	Pilin (bacterial filament); Region: Pilin; pfam00114
868597010529	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
868597010530	RDD family; Region: RDD; pfam06271
868597010531	DNA topoisomerase I; Provisional; Region: PRK08780
868597010532	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
868597010533	active site
868597010534	interdomain interaction site; other site
868597010535	putative metal-binding site [ion binding]; other site
868597010536	nucleotide binding site [chemical binding]; other site
868597010537	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
868597010538	domain I; other site
868597010539	DNA binding groove [nucleotide binding]
868597010540	phosphate binding site [ion binding]; other site
868597010541	domain II; other site
868597010542	domain III; other site
868597010543	nucleotide binding site [chemical binding]; other site
868597010544	catalytic site [active]
868597010545	domain IV; other site
868597010546	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
868597010547	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
868597010548	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
868597010549	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
868597010550	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
868597010551	tropinone reductase; Provisional; Region: PRK09242
868597010552	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597010553	NAD(P) binding site [chemical binding]; other site
868597010554	active site
868597010555	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
868597010556	tandem repeat interface [polypeptide binding]; other site
868597010557	oligomer interface [polypeptide binding]; other site
868597010558	active site residues [active]
868597010559	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
868597010560	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
868597010561	tandem repeat interface [polypeptide binding]; other site
868597010562	oligomer interface [polypeptide binding]; other site
868597010563	active site residues [active]
868597010564	multidrug efflux protein; Reviewed; Region: PRK01766
868597010565	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
868597010566	cation binding site [ion binding]; other site
868597010567	primosome assembly protein PriA; Validated; Region: PRK05580
868597010568	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
868597010569	ATP binding site [chemical binding]; other site
868597010570	putative Mg++ binding site [ion binding]; other site
868597010571	helicase superfamily c-terminal domain; Region: HELICc; smart00490
868597010572	nucleotide binding region [chemical binding]; other site
868597010573	ATP-binding site [chemical binding]; other site
868597010574	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
868597010575	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
868597010576	putative C-terminal domain interface [polypeptide binding]; other site
868597010577	putative GSH binding site (G-site) [chemical binding]; other site
868597010578	putative dimer interface [polypeptide binding]; other site
868597010579	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
868597010580	putative N-terminal domain interface [polypeptide binding]; other site
868597010581	putative dimer interface [polypeptide binding]; other site
868597010582	putative substrate binding pocket (H-site) [chemical binding]; other site
868597010583	Uncharacterized conserved protein [Function unknown]; Region: COG1432
868597010584	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
868597010585	putative metal binding site [ion binding]; other site
868597010586	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
868597010587	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
868597010588	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
868597010589	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
868597010590	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
868597010591	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
868597010592	GIY-YIG motif/motif A; other site
868597010593	putative active site [active]
868597010594	putative metal binding site [ion binding]; other site
868597010595	Predicted membrane protein [Function unknown]; Region: COG2860
868597010596	UPF0126 domain; Region: UPF0126; pfam03458
868597010597	UPF0126 domain; Region: UPF0126; pfam03458
868597010598	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
868597010599	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
868597010600	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
868597010601	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
868597010602	MarR family; Region: MarR_2; cl17246
868597010603	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597010604	dimer interface [polypeptide binding]; other site
868597010605	phosphorylation site [posttranslational modification]
868597010606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597010607	ATP binding site [chemical binding]; other site
868597010608	Mg2+ binding site [ion binding]; other site
868597010609	G-X-G motif; other site
868597010610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010611	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597010612	active site
868597010613	phosphorylation site [posttranslational modification]
868597010614	intermolecular recognition site; other site
868597010615	dimerization interface [polypeptide binding]; other site
868597010616	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597010617	DNA binding site [nucleotide binding]
868597010618	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
868597010619	catalytic motif [active]
868597010620	Catalytic residue [active]
868597010621	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
868597010622	Beta-lactamase; Region: Beta-lactamase; pfam00144
868597010623	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
868597010624	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
868597010625	ring oligomerisation interface [polypeptide binding]; other site
868597010626	ATP/Mg binding site [chemical binding]; other site
868597010627	stacking interactions; other site
868597010628	hinge regions; other site
868597010629	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
868597010630	oligomerisation interface [polypeptide binding]; other site
868597010631	mobile loop; other site
868597010632	roof hairpin; other site
868597010633	Bacterial Ig-like domain; Region: Big_5; pfam13205
868597010634	Endonuclease I; Region: Endonuclease_1; pfam04231
868597010635	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
868597010636	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
868597010637	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
868597010638	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
868597010639	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
868597010640	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
868597010641	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
868597010642	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
868597010643	catalytic residues [active]
868597010644	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
868597010645	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
868597010646	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
868597010647	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
868597010648	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
868597010649	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
868597010650	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
868597010651	FAD binding pocket [chemical binding]; other site
868597010652	FAD binding motif [chemical binding]; other site
868597010653	catalytic residues [active]
868597010654	NAD binding pocket [chemical binding]; other site
868597010655	phosphate binding motif [ion binding]; other site
868597010656	beta-alpha-beta structure motif; other site
868597010657	HAMP domain; Region: HAMP; pfam00672
868597010658	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
868597010659	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597010660	dimer interface [polypeptide binding]; other site
868597010661	putative CheW interface [polypeptide binding]; other site
868597010662	N-acetyltransferase; Region: Acetyltransf_2; cl00949
868597010663	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
868597010664	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
868597010665	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
868597010666	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
868597010667	substrate binding pocket [chemical binding]; other site
868597010668	membrane-bound complex binding site; other site
868597010669	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
868597010670	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597010671	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
868597010672	dimerization interface [polypeptide binding]; other site
868597010673	substrate binding pocket [chemical binding]; other site
868597010674	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
868597010675	active site
868597010676	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
868597010677	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
868597010678	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
868597010679	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
868597010680	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
868597010681	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
868597010682	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
868597010683	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
868597010684	tetramer interface [polypeptide binding]; other site
868597010685	active site
868597010686	Mg2+/Mn2+ binding site [ion binding]; other site
868597010687	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
868597010688	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
868597010689	Dehydroquinase class II; Region: DHquinase_II; pfam01220
868597010690	active site
868597010691	trimer interface [polypeptide binding]; other site
868597010692	dimer interface [polypeptide binding]; other site
868597010693	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
868597010694	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
868597010695	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
868597010696	carboxyltransferase (CT) interaction site; other site
868597010697	biotinylation site [posttranslational modification]; other site
868597010698	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
868597010699	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
868597010700	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
868597010701	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
868597010702	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
868597010703	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
868597010704	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
868597010705	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
868597010706	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
868597010707	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
868597010708	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
868597010709	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
868597010710	putative acyl-acceptor binding pocket; other site
868597010711	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
868597010712	active site
868597010713	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
868597010714	active site
868597010715	catalytic residues [active]
868597010716	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
868597010717	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
868597010718	Putative methyltransferase; Region: Methyltransf_20; pfam12147
868597010719	Methyltransferase domain; Region: Methyltransf_31; pfam13847
868597010720	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
868597010721	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
868597010722	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
868597010723	purine monophosphate binding site [chemical binding]; other site
868597010724	dimer interface [polypeptide binding]; other site
868597010725	putative catalytic residues [active]
868597010726	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
868597010727	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
868597010728	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
868597010729	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
868597010730	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
868597010731	Predicted transcriptional regulator [Transcription]; Region: COG2944
868597010732	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
868597010733	non-specific DNA binding site [nucleotide binding]; other site
868597010734	salt bridge; other site
868597010735	sequence-specific DNA binding site [nucleotide binding]; other site
868597010736	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
868597010737	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
868597010738	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
868597010739	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597010740	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597010741	DNA binding residues [nucleotide binding]
868597010742	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
868597010743	ligand binding site [chemical binding]; other site
868597010744	active site
868597010745	UGI interface [polypeptide binding]; other site
868597010746	catalytic site [active]
868597010747	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597010748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010749	active site
868597010750	phosphorylation site [posttranslational modification]
868597010751	intermolecular recognition site; other site
868597010752	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597010753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010754	active site
868597010755	phosphorylation site [posttranslational modification]
868597010756	intermolecular recognition site; other site
868597010757	dimerization interface [polypeptide binding]; other site
868597010758	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
868597010759	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
868597010760	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
868597010761	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597010762	Walker A/P-loop; other site
868597010763	ATP binding site [chemical binding]; other site
868597010764	Q-loop/lid; other site
868597010765	ABC transporter signature motif; other site
868597010766	Walker B; other site
868597010767	D-loop; other site
868597010768	H-loop/switch region; other site
868597010769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597010770	S-adenosylmethionine binding site [chemical binding]; other site
868597010771	helicase 45; Provisional; Region: PTZ00424
868597010772	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
868597010773	ATP binding site [chemical binding]; other site
868597010774	Mg++ binding site [ion binding]; other site
868597010775	motif III; other site
868597010776	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597010777	nucleotide binding region [chemical binding]; other site
868597010778	ATP-binding site [chemical binding]; other site
868597010779	Protein of unknown function (DUF3628); Region: DUF3628; pfam12300
868597010780	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
868597010781	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
868597010782	catalytic residues [active]
868597010783	transcription termination factor Rho; Provisional; Region: rho; PRK09376
868597010784	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
868597010785	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
868597010786	RNA binding site [nucleotide binding]; other site
868597010787	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
868597010788	multimer interface [polypeptide binding]; other site
868597010789	Walker A motif; other site
868597010790	ATP binding site [chemical binding]; other site
868597010791	Walker B motif; other site
868597010792	Cache domain; Region: Cache_1; pfam02743
868597010793	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
868597010794	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597010795	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597010796	metal binding site [ion binding]; metal-binding site
868597010797	active site
868597010798	I-site; other site
868597010799	Gram-negative bacterial tonB protein; Region: TonB; cl10048
868597010800	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597010801	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
868597010802	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
868597010803	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
868597010804	G1 box; other site
868597010805	GTP/Mg2+ binding site [chemical binding]; other site
868597010806	G2 box; other site
868597010807	Switch I region; other site
868597010808	G3 box; other site
868597010809	Switch II region; other site
868597010810	G4 box; other site
868597010811	G5 box; other site
868597010812	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
868597010813	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
868597010814	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
868597010815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
868597010816	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
868597010817	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
868597010818	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
868597010819	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
868597010820	metal binding site [ion binding]; metal-binding site
868597010821	putative dimer interface [polypeptide binding]; other site
868597010822	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597010823	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597010824	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597010825	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
868597010826	Protein export membrane protein; Region: SecD_SecF; cl14618
868597010827	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
868597010828	Protein export membrane protein; Region: SecD_SecF; cl14618
868597010829	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
868597010830	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
868597010831	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
868597010832	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
868597010833	classical (c) SDRs; Region: SDR_c; cd05233
868597010834	NAD(P) binding site [chemical binding]; other site
868597010835	active site
868597010836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597010837	putative substrate translocation pore; other site
868597010838	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
868597010839	putative acyl-acceptor binding pocket; other site
868597010840	Interferon-induced transmembrane protein; Region: CD225; pfam04505
868597010841	Interferon-induced transmembrane protein; Region: CD225; pfam04505
868597010842	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
868597010843	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
868597010844	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
868597010845	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
868597010846	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
868597010847	putative NADH binding site [chemical binding]; other site
868597010848	putative active site [active]
868597010849	nudix motif; other site
868597010850	putative metal binding site [ion binding]; other site
868597010851	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
868597010852	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
868597010853	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
868597010854	Myosin tail; Region: Myosin_tail_1; pfam01576
868597010855	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
868597010856	Response regulator receiver domain; Region: Response_reg; pfam00072
868597010857	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010858	active site
868597010859	phosphorylation site [posttranslational modification]
868597010860	intermolecular recognition site; other site
868597010861	dimerization interface [polypeptide binding]; other site
868597010862	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597010863	metal binding site [ion binding]; metal-binding site
868597010864	active site
868597010865	I-site; other site
868597010866	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
868597010867	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597010868	dimer interface [polypeptide binding]; other site
868597010869	phosphorylation site [posttranslational modification]
868597010870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597010871	ATP binding site [chemical binding]; other site
868597010872	Mg2+ binding site [ion binding]; other site
868597010873	G-X-G motif; other site
868597010874	Response regulator receiver domain; Region: Response_reg; pfam00072
868597010875	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597010876	active site
868597010877	phosphorylation site [posttranslational modification]
868597010878	intermolecular recognition site; other site
868597010879	dimerization interface [polypeptide binding]; other site
868597010880	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
868597010881	putative binding surface; other site
868597010882	active site
868597010883	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
868597010884	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
868597010885	heme binding site [chemical binding]; other site
868597010886	ferroxidase pore; other site
868597010887	ferroxidase diiron center [ion binding]; other site
868597010888	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
868597010889	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
868597010890	putative active site [active]
868597010891	Ap4A binding site [chemical binding]; other site
868597010892	nudix motif; other site
868597010893	putative metal binding site [ion binding]; other site
868597010894	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
868597010895	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
868597010896	23S rRNA interface [nucleotide binding]; other site
868597010897	L3 interface [polypeptide binding]; other site
868597010898	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
868597010899	diiron binding motif [ion binding]; other site
868597010900	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
868597010901	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
868597010902	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
868597010903	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
868597010904	ligand binding site [chemical binding]; other site
868597010905	flexible hinge region; other site
868597010906	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
868597010907	putative switch regulator; other site
868597010908	non-specific DNA interactions [nucleotide binding]; other site
868597010909	DNA binding site [nucleotide binding]
868597010910	sequence specific DNA binding site [nucleotide binding]; other site
868597010911	putative cAMP binding site [chemical binding]; other site
868597010912	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
868597010913	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
868597010914	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
868597010915	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
868597010916	active site
868597010917	ribulose/triose binding site [chemical binding]; other site
868597010918	phosphate binding site [ion binding]; other site
868597010919	substrate (anthranilate) binding pocket [chemical binding]; other site
868597010920	product (indole) binding pocket [chemical binding]; other site
868597010921	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
868597010922	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
868597010923	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
868597010924	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
868597010925	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
868597010926	glutamine binding [chemical binding]; other site
868597010927	catalytic triad [active]
868597010928	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
868597010929	anthranilate synthase component I; Provisional; Region: PRK13565
868597010930	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
868597010931	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
868597010932	lipid kinase; Reviewed; Region: PRK13054
868597010933	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
868597010934	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
868597010935	Coenzyme A binding pocket [chemical binding]; other site
868597010936	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
868597010937	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
868597010938	substrate binding site [chemical binding]; other site
868597010939	hexamer interface [polypeptide binding]; other site
868597010940	metal binding site [ion binding]; metal-binding site
868597010941	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
868597010942	HSP70 interaction site [polypeptide binding]; other site
868597010943	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
868597010944	ATP binding site [chemical binding]; other site
868597010945	active site
868597010946	substrate binding site [chemical binding]; other site
868597010947	Protein of unknown function (DUF962); Region: DUF962; cl01879
868597010948	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
868597010949	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
868597010950	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
868597010951	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
868597010952	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
868597010953	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
868597010954	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
868597010955	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
868597010956	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
868597010957	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
868597010958	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
868597010959	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
868597010960	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
868597010961	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
868597010962	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
868597010963	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
868597010964	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
868597010965	dimer interface [polypeptide binding]; other site
868597010966	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
868597010967	active site
868597010968	Fe binding site [ion binding]; other site
868597010969	Transcriptional regulators [Transcription]; Region: MarR; COG1846
868597010970	MarR family; Region: MarR_2; pfam12802
868597010971	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
868597010972	POT family; Region: PTR2; cl17359
868597010973	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
868597010974	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
868597010975	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
868597010976	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
868597010977	TPP-binding site [chemical binding]; other site
868597010978	tetramer interface [polypeptide binding]; other site
868597010979	heterodimer interface [polypeptide binding]; other site
868597010980	phosphorylation loop region [posttranslational modification]
868597010981	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
868597010982	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
868597010983	alpha subunit interface [polypeptide binding]; other site
868597010984	TPP binding site [chemical binding]; other site
868597010985	heterodimer interface [polypeptide binding]; other site
868597010986	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
868597010987	Variant SH3 domain; Region: SH3_2; pfam07653
868597010988	Src Homology 3 domain superfamily; Region: SH3; cl17036
868597010989	peptide ligand binding site [polypeptide binding]; other site
868597010990	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
868597010991	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
868597010992	E3 interaction surface; other site
868597010993	lipoyl attachment site [posttranslational modification]; other site
868597010994	e3 binding domain; Region: E3_binding; pfam02817
868597010995	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
868597010996	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
868597010997	putative dimer interface [polypeptide binding]; other site
868597010998	HTH domain; Region: HTH_11; pfam08279
868597010999	Predicted transcriptional regulator [Transcription]; Region: COG2378
868597011000	WYL domain; Region: WYL; pfam13280
868597011001	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597011002	NAD(P) binding site [chemical binding]; other site
868597011003	active site
868597011004	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597011005	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597011006	metal binding site [ion binding]; metal-binding site
868597011007	active site
868597011008	I-site; other site
868597011009	Protein of unknown function (DUF808); Region: DUF808; pfam05661
868597011010	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
868597011011	ABC1 family; Region: ABC1; cl17513
868597011012	phosphoglycerol transferase I; Provisional; Region: PRK12363
868597011013	Sulfatase; Region: Sulfatase; cl17466
868597011014	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
868597011015	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
868597011016	Mechanosensitive ion channel; Region: MS_channel; pfam00924
868597011017	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
868597011018	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
868597011019	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
868597011020	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
868597011021	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
868597011022	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
868597011023	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
868597011024	Predicted membrane protein [Function unknown]; Region: COG3212
868597011025	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
868597011026	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
868597011027	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597011028	active site
868597011029	phosphorylation site [posttranslational modification]
868597011030	intermolecular recognition site; other site
868597011031	dimerization interface [polypeptide binding]; other site
868597011032	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597011033	DNA binding site [nucleotide binding]
868597011034	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597011035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597011036	ATP binding site [chemical binding]; other site
868597011037	Mg2+ binding site [ion binding]; other site
868597011038	G-X-G motif; other site
868597011039	arginine decarboxylase; Provisional; Region: PRK05354
868597011040	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
868597011041	dimer interface [polypeptide binding]; other site
868597011042	active site
868597011043	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
868597011044	catalytic residues [active]
868597011045	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
868597011046	spermidine synthase; Provisional; Region: PRK00811
868597011047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597011048	S-adenosylmethionine binding site [chemical binding]; other site
868597011049	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
868597011050	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
868597011051	active site
868597011052	ATP binding site [chemical binding]; other site
868597011053	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
868597011054	Nitrogen regulatory protein P-II; Region: P-II; smart00938
868597011055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
868597011056	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
868597011057	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
868597011058	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
868597011059	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
868597011060	Protein of unknown function (DUF998); Region: DUF998; pfam06197
868597011061	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
868597011062	Abi-like protein; Region: Abi_2; pfam07751
868597011063	Abi-like protein; Region: Abi_2; pfam07751
868597011064	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597011065	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597011066	sugar phosphate phosphatase; Provisional; Region: PRK10513
868597011067	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597011068	active site
868597011069	motif I; other site
868597011070	motif II; other site
868597011071	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
868597011072	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
868597011073	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
868597011074	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
868597011075	Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059
868597011076	calcium binding site 1 [ion binding]; other site
868597011077	active site
868597011078	catalytic triad [active]
868597011079	calcium binding site 2 [ion binding]; other site
868597011080	calcium binding site 3 [ion binding]; other site
868597011081	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
868597011082	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
868597011083	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
868597011084	Cu(I) binding site [ion binding]; other site
868597011085	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
868597011086	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
868597011087	Subunit I/III interface [polypeptide binding]; other site
868597011088	Subunit III/IV interface [polypeptide binding]; other site
868597011089	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
868597011090	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
868597011091	D-pathway; other site
868597011092	Putative ubiquinol binding site [chemical binding]; other site
868597011093	Low-spin heme (heme b) binding site [chemical binding]; other site
868597011094	Putative water exit pathway; other site
868597011095	Binuclear center (heme o3/CuB) [ion binding]; other site
868597011096	K-pathway; other site
868597011097	Putative proton exit pathway; other site
868597011098	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
868597011099	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
868597011100	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
868597011101	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
868597011102	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
868597011103	DNA-binding site [nucleotide binding]; DNA binding site
868597011104	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597011105	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597011106	homodimer interface [polypeptide binding]; other site
868597011107	catalytic residue [active]
868597011108	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
868597011109	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
868597011110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
868597011111	DNA-binding site [nucleotide binding]; DNA binding site
868597011112	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
868597011113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597011114	homodimer interface [polypeptide binding]; other site
868597011115	catalytic residue [active]
868597011116	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
868597011117	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
868597011118	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597011119	catalytic residue [active]
868597011120	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
868597011121	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
868597011122	N-terminal plug; other site
868597011123	ligand-binding site [chemical binding]; other site
868597011124	Helix-turn-helix domain; Region: HTH_18; pfam12833
868597011125	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
868597011126	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
868597011127	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
868597011128	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
868597011129	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
868597011130	Zn binding site [ion binding]; other site
868597011131	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708
868597011132	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
868597011133	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
868597011134	UbiA prenyltransferase family; Region: UbiA; pfam01040
868597011135	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597011136	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597011137	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
868597011138	catalytic motif [active]
868597011139	Catalytic residue [active]
868597011140	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
868597011141	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
868597011142	potential frameshift: common BLAST hit: gi|190574709|ref|YP_001972554.1|  Rhs family transmembrane protein
868597011143	RHS Repeat; Region: RHS_repeat; cl11982
868597011144	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
868597011145	RHS Repeat; Region: RHS_repeat; pfam05593
868597011146	RHS Repeat; Region: RHS_repeat; pfam05593
868597011147	RHS Repeat; Region: RHS_repeat; pfam05593
868597011148	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
868597011149	RHS Repeat; Region: RHS_repeat; cl11982
868597011150	RHS Repeat; Region: RHS_repeat; pfam05593
868597011151	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
868597011152	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
868597011153	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597011154	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
868597011155	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
868597011156	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
868597011157	CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596
868597011158	putative active site [active]
868597011159	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
868597011160	putative catalytic site [active]
868597011161	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
868597011162	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
868597011163	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
868597011164	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
868597011165	dimer interface [polypeptide binding]; other site
868597011166	active site
868597011167	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
868597011168	putative active site [active]
868597011169	fructokinase; Reviewed; Region: PRK09557
868597011170	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
868597011171	nucleotide binding site [chemical binding]; other site
868597011172	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
868597011173	DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802
868597011174	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
868597011175	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
868597011176	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
868597011177	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
868597011178	active site
868597011179	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
868597011180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597011181	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
868597011182	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
868597011183	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
868597011184	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
868597011185	active site
868597011186	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
868597011187	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
868597011188	putative ion selectivity filter; other site
868597011189	putative pore gating glutamate residue; other site
868597011190	putative H+/Cl- coupling transport residue; other site
868597011191	NLI interacting factor-like phosphatase; Region: NIF; pfam03031
868597011192	FCP1-like phosphatase, phosphatase domain; Region: FCP1_euk; TIGR02250
868597011193	Protein of unknown function; Region: DUF3658; pfam12395
868597011194	biotin synthase; Provisional; Region: PRK15108
868597011195	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
868597011196	FeS/SAM binding site; other site
868597011197	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
868597011198	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
868597011199	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
868597011200	catalytic residue [active]
868597011201	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
868597011202	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
868597011203	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
868597011204	putative NAD(P) binding site [chemical binding]; other site
868597011205	putative active site [active]
868597011206	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
868597011207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597011208	S-adenosylmethionine binding site [chemical binding]; other site
868597011209	Uncharacterized conserved protein [Function unknown]; Region: COG1434
868597011210	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
868597011211	putative active site [active]
868597011212	serine racemase; Region: PLN02970
868597011213	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
868597011214	tetramer interface [polypeptide binding]; other site
868597011215	pyridoxal 5'-phosphate binding site [chemical binding]; other site
868597011216	catalytic residue [active]
868597011217	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
868597011218	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
868597011219	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
868597011220	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
868597011221	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
868597011222	Protein export membrane protein; Region: SecD_SecF; cl14618
868597011223	Protein export membrane protein; Region: SecD_SecF; cl14618
868597011224	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
868597011225	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597011226	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597011227	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
868597011228	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
868597011229	dimerization interface [polypeptide binding]; other site
868597011230	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597011231	dimer interface [polypeptide binding]; other site
868597011232	phosphorylation site [posttranslational modification]
868597011233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597011234	ATP binding site [chemical binding]; other site
868597011235	Mg2+ binding site [ion binding]; other site
868597011236	G-X-G motif; other site
868597011237	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
868597011238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597011239	active site
868597011240	phosphorylation site [posttranslational modification]
868597011241	intermolecular recognition site; other site
868597011242	dimerization interface [polypeptide binding]; other site
868597011243	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
868597011244	DNA binding site [nucleotide binding]
868597011245	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
868597011246	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
868597011247	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
868597011248	trimer interface [polypeptide binding]; other site
868597011249	putative metal binding site [ion binding]; other site
868597011250	RDD family; Region: RDD; pfam06271
868597011251	Integral membrane protein DUF95; Region: DUF95; pfam01944
868597011252	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
868597011253	MoxR-like ATPases [General function prediction only]; Region: COG0714
868597011254	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
868597011255	Walker A motif; other site
868597011256	ATP binding site [chemical binding]; other site
868597011257	Walker B motif; other site
868597011258	arginine finger; other site
868597011259	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
868597011260	Protein of unknown function DUF58; Region: DUF58; pfam01882
868597011261	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
868597011262	Protein of unknown function (DUF1190); Region: DUF1190; pfam06693
868597011263	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
868597011264	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
868597011265	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
868597011266	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
868597011267	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
868597011268	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
868597011269	shikimate binding site; other site
868597011270	NAD(P) binding site [chemical binding]; other site
868597011271	DMAP1-binding Domain; Region: DMAP_binding; pfam06464
868597011272	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
868597011273	dimer interface [polypeptide binding]; other site
868597011274	allosteric magnesium binding site [ion binding]; other site
868597011275	active site
868597011276	aspartate-rich active site metal binding site; other site
868597011277	Schiff base residues; other site
868597011278	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
868597011279	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
868597011280	Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695
868597011281	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
868597011282	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597011283	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
868597011284	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
868597011285	C-terminal domain interface [polypeptide binding]; other site
868597011286	GSH binding site (G-site) [chemical binding]; other site
868597011287	dimer interface [polypeptide binding]; other site
868597011288	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
868597011289	N-terminal domain interface [polypeptide binding]; other site
868597011290	putative dimer interface [polypeptide binding]; other site
868597011291	active site
868597011292	hypothetical protein; Provisional; Region: PRK05208
868597011293	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
868597011294	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
868597011295	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
868597011296	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
868597011297	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
868597011298	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
868597011299	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
868597011300	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
868597011301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
868597011302	Walker A/P-loop; other site
868597011303	ATP binding site [chemical binding]; other site
868597011304	Q-loop/lid; other site
868597011305	ABC transporter signature motif; other site
868597011306	Walker B; other site
868597011307	D-loop; other site
868597011308	H-loop/switch region; other site
868597011309	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
868597011310	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
868597011311	TAP-like protein; Region: Abhydrolase_4; pfam08386
868597011312	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597011313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597011314	metal binding site [ion binding]; metal-binding site
868597011315	active site
868597011316	I-site; other site
868597011317	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
868597011318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
868597011319	Chitin binding domain; Region: Chitin_bind_3; pfam03067
868597011320	Chitin binding domain; Region: Chitin_bind_3; pfam03067
868597011321	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
868597011322	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
868597011323	FAD binding pocket [chemical binding]; other site
868597011324	FAD binding motif [chemical binding]; other site
868597011325	phosphate binding motif [ion binding]; other site
868597011326	beta-alpha-beta structure motif; other site
868597011327	NAD binding pocket [chemical binding]; other site
868597011328	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
868597011329	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
868597011330	Walker A/P-loop; other site
868597011331	ATP binding site [chemical binding]; other site
868597011332	Q-loop/lid; other site
868597011333	ABC transporter signature motif; other site
868597011334	Walker B; other site
868597011335	D-loop; other site
868597011336	H-loop/switch region; other site
868597011337	inner membrane transport permease; Provisional; Region: PRK15066
868597011338	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
868597011339	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
868597011340	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
868597011341	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
868597011342	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
868597011343	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
868597011344	putative NAD(P) binding site [chemical binding]; other site
868597011345	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
868597011346	active site
868597011347	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
868597011348	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
868597011349	ATP binding site [chemical binding]; other site
868597011350	putative Mg++ binding site [ion binding]; other site
868597011351	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
868597011352	nucleotide binding region [chemical binding]; other site
868597011353	Helicase associated domain (HA2); Region: HA2; cl04503
868597011354	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
868597011355	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
868597011356	pseudouridine synthase; Region: TIGR00093
868597011357	active site
868597011358	Predicted methyltransferase [General function prediction only]; Region: COG4798
868597011359	Methyltransferase domain; Region: Methyltransf_23; pfam13489
868597011360	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
868597011361	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
868597011362	active site
868597011363	catalytic tetrad [active]
868597011364	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
868597011365	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
868597011366	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
868597011367	hypothetical protein; Reviewed; Region: PRK09588
868597011368	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
868597011369	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
868597011370	Transcriptional regulator; Region: Rrf2; pfam02082
868597011371	Predicted transcriptional regulator [Transcription]; Region: COG1959
868597011372	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
868597011373	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597011374	dimer interface [polypeptide binding]; other site
868597011375	putative CheW interface [polypeptide binding]; other site
868597011376	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
868597011377	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
868597011378	active site
868597011379	catalytic tetrad [active]
868597011380	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
868597011381	TAP-like protein; Region: Abhydrolase_4; pfam08386
868597011382	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
868597011383	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
868597011384	CoA binding domain; Region: CoA_binding_2; pfam13380
868597011385	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
868597011386	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
868597011387	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
868597011388	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
868597011389	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
868597011390	MgtE intracellular N domain; Region: MgtE_N; smart00924
868597011391	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
868597011392	Divalent cation transporter; Region: MgtE; pfam01769
868597011393	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
868597011394	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
868597011395	TrkA-N domain; Region: TrkA_N; pfam02254
868597011396	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
868597011397	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
868597011398	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
868597011399	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
868597011400	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
868597011401	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
868597011402	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
868597011403	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
868597011404	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
868597011405	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
868597011406	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
868597011407	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
868597011408	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
868597011409	YcgL domain; Region: YcgL; pfam05166
868597011410	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
868597011411	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
868597011412	dimer interface [polypeptide binding]; other site
868597011413	active site
868597011414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
868597011415	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
868597011416	NAD(P) binding site [chemical binding]; other site
868597011417	active site
868597011418	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
868597011419	active site 2 [active]
868597011420	active site 1 [active]
868597011421	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
868597011422	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
868597011423	dimer interface [polypeptide binding]; other site
868597011424	active site
868597011425	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
868597011426	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
868597011427	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
868597011428	Predicted exporter [General function prediction only]; Region: COG4258
868597011429	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
868597011430	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
868597011431	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
868597011432	active site
868597011433	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
868597011434	active sites [active]
868597011435	tetramer interface [polypeptide binding]; other site
868597011436	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
868597011437	putative acyl-acceptor binding pocket; other site
868597011438	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
868597011439	Ligand binding site; other site
868597011440	Putative Catalytic site; other site
868597011441	DXD motif; other site
868597011442	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
868597011443	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
868597011444	AMP binding site [chemical binding]; other site
868597011445	active site
868597011446	acyl-activating enzyme (AAE) consensus motif; other site
868597011447	CoA binding site [chemical binding]; other site
868597011448	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
868597011449	active site 2 [active]
868597011450	dimer interface [polypeptide binding]; other site
868597011451	active site 1 [active]
868597011452	Predicted membrane protein [Function unknown]; Region: COG4648
868597011453	acyl carrier protein; Provisional; Region: PRK05350
868597011454	Phosphopantetheine attachment site; Region: PP-binding; cl09936
868597011455	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
868597011456	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
868597011457	putative acyl-acceptor binding pocket; other site
868597011458	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
868597011459	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
868597011460	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
868597011461	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
868597011462	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
868597011463	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
868597011464	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
868597011465	DNA binding residues [nucleotide binding]
868597011466	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
868597011467	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
868597011468	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
868597011469	nudix motif; other site
868597011470	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
868597011471	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
868597011472	Predicted membrane protein [Function unknown]; Region: COG2323
868597011473	DNA polymerase I; Provisional; Region: PRK05755
868597011474	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
868597011475	active site
868597011476	metal binding site 1 [ion binding]; metal-binding site
868597011477	putative 5' ssDNA interaction site; other site
868597011478	metal binding site 3; metal-binding site
868597011479	metal binding site 2 [ion binding]; metal-binding site
868597011480	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
868597011481	putative DNA binding site [nucleotide binding]; other site
868597011482	putative metal binding site [ion binding]; other site
868597011483	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
868597011484	active site
868597011485	catalytic site [active]
868597011486	substrate binding site [chemical binding]; other site
868597011487	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
868597011488	active site
868597011489	DNA binding site [nucleotide binding]
868597011490	catalytic site [active]
868597011491	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
868597011492	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
868597011493	Ligand Binding Site [chemical binding]; other site
868597011494	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
868597011495	active site
868597011496	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
868597011497	Part of AAA domain; Region: AAA_19; pfam13245
868597011498	Family description; Region: UvrD_C_2; pfam13538
868597011499	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
868597011500	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
868597011501	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
868597011502	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
868597011503	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
868597011504	putative active site [active]
868597011505	catalytic site [active]
868597011506	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
868597011507	putative active site [active]
868597011508	catalytic site [active]
868597011509	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
868597011510	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
868597011511	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597011512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597011513	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
868597011514	putative effector binding pocket; other site
868597011515	putative dimerization interface [polypeptide binding]; other site
868597011516	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
868597011517	homotrimer interaction site [polypeptide binding]; other site
868597011518	putative active site [active]
868597011519	Outer membrane efflux protein; Region: OEP; pfam02321
868597011520	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
868597011521	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
868597011522	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
868597011523	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
868597011524	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
868597011525	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
868597011526	Ligand binding site; other site
868597011527	Putative Catalytic site; other site
868597011528	DXD motif; other site
868597011529	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
868597011530	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
868597011531	putative NAD(P) binding site [chemical binding]; other site
868597011532	active site
868597011533	putative substrate binding site [chemical binding]; other site
868597011534	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
868597011535	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
868597011536	ParB-like nuclease domain; Region: ParBc; pfam02195
868597011537	KorB domain; Region: KorB; pfam08535
868597011538	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
868597011539	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
868597011540	P-loop; other site
868597011541	Magnesium ion binding site [ion binding]; other site
868597011542	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
868597011543	Magnesium ion binding site [ion binding]; other site
868597011544	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
868597011545	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
868597011546	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
868597011547	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
868597011548	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
868597011549	putative catalytic site [active]
868597011550	putative phosphate binding site [ion binding]; other site
868597011551	active site
868597011552	metal binding site A [ion binding]; metal-binding site
868597011553	DNA binding site [nucleotide binding]
868597011554	putative AP binding site [nucleotide binding]; other site
868597011555	putative metal binding site B [ion binding]; other site
868597011556	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
868597011557	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
868597011558	NAD(P) binding site [chemical binding]; other site
868597011559	catalytic residues [active]
868597011560	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
868597011561	putative substrate translocation pore; other site
868597011562	acetyl-CoA synthetase; Provisional; Region: PRK00174
868597011563	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
868597011564	active site
868597011565	CoA binding site [chemical binding]; other site
868597011566	acyl-activating enzyme (AAE) consensus motif; other site
868597011567	AMP binding site [chemical binding]; other site
868597011568	acetate binding site [chemical binding]; other site
868597011569	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
868597011570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597011571	active site
868597011572	phosphorylation site [posttranslational modification]
868597011573	intermolecular recognition site; other site
868597011574	dimerization interface [polypeptide binding]; other site
868597011575	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
868597011576	DNA binding residues [nucleotide binding]
868597011577	dimerization interface [polypeptide binding]; other site
868597011578	Predicted membrane protein [Function unknown]; Region: COG1971
868597011579	Domain of unknown function DUF; Region: DUF204; pfam02659
868597011580	Domain of unknown function DUF; Region: DUF204; pfam02659
868597011581	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
868597011582	Na binding site [ion binding]; other site
868597011583	PAS fold; Region: PAS_7; pfam12860
868597011584	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
868597011585	putative active site [active]
868597011586	heme pocket [chemical binding]; other site
868597011587	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
868597011588	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
868597011589	dimer interface [polypeptide binding]; other site
868597011590	phosphorylation site [posttranslational modification]
868597011591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
868597011592	ATP binding site [chemical binding]; other site
868597011593	Mg2+ binding site [ion binding]; other site
868597011594	G-X-G motif; other site
868597011595	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
868597011596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
868597011597	active site
868597011598	phosphorylation site [posttranslational modification]
868597011599	intermolecular recognition site; other site
868597011600	dimerization interface [polypeptide binding]; other site
868597011601	Peptidase S46; Region: Peptidase_S46; pfam10459
868597011602	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
868597011603	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
868597011604	Hsp70 protein; Region: HSP70; pfam00012
868597011605	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
868597011606	nucleotide binding site [chemical binding]; other site
868597011607	putative NEF/HSP70 interaction site [polypeptide binding]; other site
868597011608	SBD interface [polypeptide binding]; other site
868597011609	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
868597011610	HSP70 interaction site [polypeptide binding]; other site
868597011611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
868597011612	Family of unknown function (DUF490); Region: DUF490; pfam04357
868597011613	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
868597011614	Surface antigen; Region: Bac_surface_Ag; pfam01103
868597011615	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
868597011616	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
868597011617	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
868597011618	dimer interface [polypeptide binding]; other site
868597011619	motif 1; other site
868597011620	active site
868597011621	motif 2; other site
868597011622	motif 3; other site
868597011623	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
868597011624	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
868597011625	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
868597011626	Walker A motif; other site
868597011627	ATP binding site [chemical binding]; other site
868597011628	Walker B motif; other site
868597011629	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
868597011630	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
868597011631	catalytic triad [active]
868597011632	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
868597011633	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
868597011634	twin arginine translocase protein A; Provisional; Region: tatA; PRK04561
868597011635	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
868597011636	putative amphipathic alpha helix; other site
868597011637	ferrochelatase; Reviewed; Region: hemH; PRK00035
868597011638	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
868597011639	C-terminal domain interface [polypeptide binding]; other site
868597011640	active site
868597011641	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
868597011642	active site
868597011643	N-terminal domain interface [polypeptide binding]; other site
868597011644	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
868597011645	PAS domain; Region: PAS_9; pfam13426
868597011646	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
868597011647	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
868597011648	dimer interface [polypeptide binding]; other site
868597011649	putative CheW interface [polypeptide binding]; other site
868597011650	Benzoate membrane transport protein; Region: BenE; pfam03594
868597011651	benzoate transporter; Region: benE; TIGR00843
868597011652	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
868597011653	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
868597011654	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
868597011655	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
868597011656	active site
868597011657	phosphate binding residues; other site
868597011658	catalytic residues [active]
868597011659	Transglycosylase SLT domain; Region: SLT_2; pfam13406
868597011660	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
868597011661	N-acetyl-D-glucosamine binding site [chemical binding]; other site
868597011662	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
868597011663	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
868597011664	Methyltransferase domain; Region: Methyltransf_25; pfam13649
868597011665	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
868597011666	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
868597011667	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
868597011668	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
868597011669	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
868597011670	metal binding site [ion binding]; metal-binding site
868597011671	active site
868597011672	I-site; other site
868597011673	hypothetical protein; Provisional; Region: PRK04233
868597011674	hypothetical protein; Provisional; Region: PRK10621
868597011675	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
868597011676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
868597011677	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
868597011678	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
868597011679	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
868597011680	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
868597011681	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
868597011682	GTP cyclohydrolase I; Provisional; Region: PLN03044
868597011683	active site
868597011684	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
868597011685	MarR family; Region: MarR_2; pfam12802
868597011686	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
868597011687	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
868597011688	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
868597011689	HlyD family secretion protein; Region: HlyD_3; pfam13437
868597011690	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
868597011691	Fusaric acid resistance protein family; Region: FUSC; pfam04632
868597011692	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
868597011693	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
868597011694	AAA domain; Region: AAA_30; pfam13604
868597011695	Family description; Region: UvrD_C_2; pfam13538
868597011696	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
868597011697	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
868597011698	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
868597011699	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
868597011700	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
868597011701	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
868597011702	Walker A/P-loop; other site
868597011703	ATP binding site [chemical binding]; other site
868597011704	Q-loop/lid; other site
868597011705	ABC transporter signature motif; other site
868597011706	Walker B; other site
868597011707	D-loop; other site
868597011708	H-loop/switch region; other site
868597011709	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
868597011710	Permease; Region: Permease; pfam02405
868597011711	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
868597011712	mce related protein; Region: MCE; pfam02470
868597011713	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
868597011714	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
868597011715	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
868597011716	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
868597011717	catalytic residues [active]
868597011718	dimer interface [polypeptide binding]; other site
868597011719	RmuC family; Region: RmuC; pfam02646
868597011720	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
868597011721	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
868597011722	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
868597011723	putative N-terminal domain interface [polypeptide binding]; other site
868597011724	putative dimer interface [polypeptide binding]; other site
868597011725	putative substrate binding pocket (H-site) [chemical binding]; other site
868597011726	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
868597011727	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
868597011728	putative NAD(P) binding site [chemical binding]; other site
868597011729	dimer interface [polypeptide binding]; other site
868597011730	Transcriptional regulator [Transcription]; Region: LysR; COG0583
868597011731	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
868597011732	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
868597011733	putative effector binding pocket; other site
868597011734	dimerization interface [polypeptide binding]; other site
868597011735	LysE type translocator; Region: LysE; cl00565
868597011736	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
868597011737	amino acid transporter; Region: 2A0306; TIGR00909
868597011738	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
868597011739	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
868597011740	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
868597011741	active site
868597011742	dimer interface [polypeptide binding]; other site
868597011743	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
868597011744	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
868597011745	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
868597011746	putative RNA binding site [nucleotide binding]; other site
868597011747	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
868597011748	S-adenosylmethionine binding site [chemical binding]; other site
868597011749	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
868597011750	Rhomboid family; Region: Rhomboid; cl11446
868597011751	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
868597011752	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
868597011753	putative active site [active]
868597011754	catalytic site [active]
868597011755	putative metal binding site [ion binding]; other site
868597011756	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
868597011757	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
868597011758	trmE is a tRNA modification GTPase; Region: trmE; cd04164
868597011759	G1 box; other site
868597011760	GTP/Mg2+ binding site [chemical binding]; other site
868597011761	Switch I region; other site
868597011762	G2 box; other site
868597011763	Switch II region; other site
868597011764	G3 box; other site
868597011765	G4 box; other site
868597011766	G5 box; other site
868597011767	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
868597011768	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
868597011769	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
868597011770	NodB motif; other site
868597011771	active site
868597011772	catalytic site [active]
868597011773	metal binding site [ion binding]; metal-binding site
868597011774	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
868597011775	Caspase domain; Region: Peptidase_C14; pfam00656
868597011776	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
868597011777	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
868597011778	TPR motif; other site
868597011779	binding surface
868597011780	membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593
868597011781	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
868597011782	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
868597011783	Ribonuclease P; Region: Ribonuclease_P; cl00457
868597011784	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399