-- dump date 20140620_080652 -- class Genbank::misc_feature -- table misc_feature_note -- id note 522373000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 522373000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 522373000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373000004 ATP binding site [chemical binding]; other site 522373000005 Walker B motif; other site 522373000006 arginine finger; other site 522373000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 522373000008 DnaA box-binding interface [nucleotide binding]; other site 522373000009 HMMPfam hit to PF00308, Bacterial dnaA protein, score 4.9e-120 522373000010 HMMPfam hit to PF08299, Bacterial dnaA protein helix-turn-helix, score 1.3e-41 522373000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 522373000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 522373000013 putative DNA binding surface [nucleotide binding]; other site 522373000014 dimer interface [polypeptide binding]; other site 522373000015 beta-clamp/clamp loader binding surface; other site 522373000016 beta-clamp/translesion DNA polymerase binding surface; other site 522373000017 HMMPfam hit to PF00712, DNA polymerase III beta subunit, N-te, score 1.2e-54 522373000018 HMMPfam hit to PF02767, DNA polymerase III beta subunit, cent, score 1.3e-50 522373000019 HMMPfam hit to PF02768, DNA polymerase III beta subunit, C-te, score 1e-40 522373000020 tgttccacgtgg 522373000021 gttccacgtggaac 522373000022 gttccacgtggaac 522373000023 tccacgtggaac 522373000024 tccacgtggaacc 522373000025 tccacgtggaac 522373000026 tccacgtggaacc 522373000027 tccacgtggaac 522373000028 tgttccacgtgg 522373000029 recombination protein F; Reviewed; Region: recF; PRK00064 522373000030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373000031 Walker A/P-loop; other site 522373000032 ATP binding site [chemical binding]; other site 522373000033 Q-loop/lid; other site 522373000034 ABC transporter signature motif; other site 522373000035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373000036 ABC transporter signature motif; other site 522373000037 Walker B; other site 522373000038 D-loop; other site 522373000039 H-loop/switch region; other site 522373000040 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 4e-08 522373000041 tgttccacgtgg 522373000042 gttccacgtggaac 522373000043 gttccacgtggaac 522373000044 tccacgtggaac 522373000045 tccacgtggaacc 522373000046 tccacgtggaac 522373000047 tccacgtggaacc 522373000048 gttccacgtggaac 522373000049 gttccacgtggaac 522373000050 tccacgtggaac 522373000051 tccacgtggaac 522373000052 tgttccacgtgg 522373000053 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 522373000054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373000055 Mg2+ binding site [ion binding]; other site 522373000056 G-X-G motif; other site 522373000057 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 522373000058 anchoring element; other site 522373000059 dimer interface [polypeptide binding]; other site 522373000060 ATP binding site [chemical binding]; other site 522373000061 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 522373000062 active site 522373000063 putative metal-binding site [ion binding]; other site 522373000064 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 522373000065 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 1.5e-28 522373000066 HMMPfam hit to PF00204, DNA gyrase B, score 5.7e-87 522373000067 HMMPfam hit to PF01751, Toprim domain, score 6.9e-06 522373000068 HMMPfam hit to PF00986, DNA gyrase B subunit, carboxyl terminus, score 6.2e-44 522373000069 CAAX protease self-immunity; Region: Abi; pfam02517 522373000070 7 probable transmembrane helices predicted for Smlt0006 by TMHMM2.0 at aa 29-51, 84-106, 127-149, 164-186, 206-223, 233-250 and 257-279 522373000071 HMMPfam hit to PF02517, CAAX amino terminal protease family, score 1.2e-14 522373000072 Peptidase family M48; Region: Peptidase_M48; pfam01435 522373000073 HMMPfam hit to PF01435, Peptidase family M48, score 6.5e-45 522373000074 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.083 522373000075 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.25 522373000076 HMMPfam hit to PF07721, Tetratricopeptide repeat, score 0.0011 522373000077 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 522373000078 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373000079 1 probable transmembrane helix predicted for Smlt0009 by TMHMM2.0 at aa 23-45 522373000080 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 1.5e-14 522373000081 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 522373000082 3 probable transmembrane helices predicted for Smlt0010 by TMHMM2.0 at aa 38-60, 161-183 and 203-225 522373000083 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 2.1e-57 522373000084 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 522373000085 TolR protein; Region: tolR; TIGR02801 522373000086 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 7.4e-15 522373000087 1 probable transmembrane helix predicted for Smlt0011 by TMHMM2.0 at aa 15-37 522373000088 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 522373000089 TolR protein; Region: tolR; TIGR02801 522373000090 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 2.9e-05 522373000091 1 probable transmembrane helix predicted for Smlt0012 by TMHMM2.0 at aa 20-42 522373000092 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 522373000093 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 522373000094 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 522373000095 putative active site [active] 522373000096 catalytic site [active] 522373000097 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 522373000098 putative active site [active] 522373000099 catalytic site [active] 522373000100 2 probable transmembrane helices predicted for Smlt0013 by TMHMM2.0 at aa 15-37 and 50-69 522373000101 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 3.9e-06 522373000102 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 1.9e-06 522373000103 1 probable transmembrane helix predicted for Smlt0014 by TMHMM2.0 at aa 20-42 522373000104 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 522373000105 active site 522373000106 hydrophilic channel; other site 522373000107 dimerization interface [polypeptide binding]; other site 522373000108 catalytic residues [active] 522373000109 active site lid [active] 522373000110 HMMPfam hit to PF03740, Pyridoxal phosphate biosynthesis protein Pdx, score 1.7e-120 522373000111 Similar to N-terminus to codon 80 of Xanthomonas campestris pv. campestris hypothetical protein xcc0015. UniProt:Q8PEG5 (364 aa) fasta scores: E()=4.4e-22, 75.949% id in 79 aa; similarity:fasta; with=UniProt:Q8PEG5; Xanthomonas campestris pv. campestris.; Hypothetical protein XCC0015.; length=364; id 75.949%; ungapped id 75.949%; E()=4.4e-22; 79 aa overlap; query 1-79; subject 1-79 522373000112 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 522373000113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373000114 non-specific DNA binding site [nucleotide binding]; other site 522373000115 salt bridge; other site 522373000116 sequence-specific DNA binding site [nucleotide binding]; other site 522373000117 HMMPfam hit to PF01381, Helix-turn-helix, score 1.4e-13 522373000118 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 522373000119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373000120 FeS/SAM binding site; other site 522373000121 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.3e-18 522373000122 NLI interacting factor-like phosphatase; Region: NIF; cl17354 522373000123 HMMPfam hit to PF03031, NLI interacting factor-like phosphatase, score 0.094 522373000124 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 522373000125 active site 522373000126 DNA binding site [nucleotide binding] 522373000127 Int/Topo IB signature motif; other site 522373000128 HMMPfam hit to PF00589, Phage integrase family, score 2e-06 522373000129 putative transposase OrfB; Reviewed; Region: PHA02517 522373000130 HTH-like domain; Region: HTH_21; pfam13276 522373000131 Integrase core domain; Region: rve; pfam00665 522373000132 Integrase core domain; Region: rve_2; pfam13333 522373000133 HMMPfam hit to PF00665, Integrase core domain, score 3.3e-32 522373000134 Transposase; Region: HTH_Tnp_1; pfam01527 522373000135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373000136 HMMPfam hit to PF01527, Transposase, score 1.1e-20 522373000137 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 522373000138 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 522373000139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373000140 AAA domain; Region: AAA_23; pfam13476 522373000141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373000142 Walker A/P-loop; other site 522373000143 Walker A/P-loop; other site 522373000144 ATP binding site [chemical binding]; other site 522373000145 ATP binding site [chemical binding]; other site 522373000146 Q-loop/lid; other site 522373000147 AAA domain; Region: AAA_21; pfam13304 522373000148 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 8.9e-05 522373000149 H+ Antiporter protein; Region: 2A0121; TIGR00900 522373000150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373000151 putative substrate translocation pore; other site 522373000152 10 probable transmembrane helices predicted for Smlt0032 by TMHMM2.0 at aa 13-35, 45-67, 87-109, 161-183, 219-241, 251-270, 282-304, 309-331, 344-363 and 373-392 522373000153 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.6e-14 522373000154 1 probable transmembrane helix predicted for Smlt0034 by TMHMM2.0 at aa 13-35 522373000155 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 522373000156 7 probable transmembrane helices predicted for Smlt0035 by TMHMM2.0 at aa 20-42, 69-86, 91-113, 118-140, 152-174, 184-206 and 218-240 522373000157 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 522373000158 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373000159 10 probable transmembrane helices predicted for Smlt0036 by TMHMM2.0 at aa 10-32, 349-371, 391-410, 449-468, 478-500, 878-900, 904-923, 932-954, 978-1000 and 1007-1029 522373000160 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 522373000161 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 522373000162 carboxyltransferase (CT) interaction site; other site 522373000163 biotinylation site [posttranslational modification]; other site 522373000164 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373000165 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 0.00023 522373000166 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 522373000167 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.0011 522373000168 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.00081 522373000169 1 probable transmembrane helix predicted for Smlt0039 by TMHMM2.0 at aa 12-31 522373000170 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 522373000171 active site 522373000172 Similar to Xanthomonas campestris pv. campestris hypothetical protein xcc0015. UniProt:Q8PEG5 (EMBL:AE012094) (364 aa) fasta scores: E()=4.2e-86, 77.352% id in 287 aa; similarity:fasta; with=UniProt:Q8PEG5 (EMBL:AE012094); Xanthomonas campestris pv. campestris.; Hypothetical protein XCC0015.; length=364; id 77.352%; ungapped id 78.723%; E()=4.2e-86; 287 aa overlap; query 3-286; subject 80-364 522373000173 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 522373000174 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 522373000175 HMMPfam hit to PF05593, RHS Repeat, score 3.1 522373000176 HMMPfam hit to PF05593, RHS Repeat, score 5.9 522373000177 HMMPfam hit to PF05593, RHS Repeat, score 7.8 522373000178 HMMPfam hit to PF05593, RHS Repeat, score 1.3 522373000179 HMMPfam hit to PF05593, RHS Repeat, score 0.58 522373000180 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 522373000181 RHS Repeat; Region: RHS_repeat; pfam05593 522373000182 RHS Repeat; Region: RHS_repeat; cl11982 522373000183 RHS Repeat; Region: RHS_repeat; pfam05593 522373000184 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 522373000185 HMMPfam hit to PF05593, RHS Repeat, score 2.2e-09 522373000186 HMMPfam hit to PF05593, RHS Repeat, score 0.0075 522373000187 HMMPfam hit to PF05593, RHS Repeat, score 2.1e-05 522373000188 HMMPfam hit to PF05593, RHS Repeat, score 0.0029 522373000189 HMMPfam hit to PF05593, RHS Repeat, score 2.8 522373000190 HMMPfam hit to PF05593, RHS Repeat, score 0.0015 522373000191 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 522373000192 fructose-1,6-bisphosphatase family protein; Region: PLN02628 522373000193 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 522373000194 AMP binding site [chemical binding]; other site 522373000195 metal binding site [ion binding]; metal-binding site 522373000196 active site 522373000197 HMMPfam hit to PF00316, Fructose-1-6-bisphosphatase, score 2.8e-164 522373000198 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 522373000199 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373000200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373000201 homodimer interface [polypeptide binding]; other site 522373000202 catalytic residue [active] 522373000203 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.2e-108 522373000204 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373000205 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373000206 N-terminal plug; other site 522373000207 ligand-binding site [chemical binding]; other site 522373000208 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.3e-17 522373000209 HMMPfam hit to PF00593, TonB dependent receptor, score 2.3e-29 522373000210 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 522373000211 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 522373000212 putative DNA binding site [nucleotide binding]; other site 522373000213 putative homodimer interface [polypeptide binding]; other site 522373000214 HMMPfam hit to PF02735, Ku70/Ku80 beta-barrel domain, score 1.9e-42 522373000215 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 522373000216 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 522373000217 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 522373000218 active site 522373000219 DNA binding site [nucleotide binding] 522373000220 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 522373000221 DNA binding site [nucleotide binding] 522373000222 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 522373000223 nucleotide binding site [chemical binding]; other site 522373000224 HMMPfam hit to PF01068, ATP dependent DNA ligase domain, score 5.8e-31 522373000225 HMMPfam hit to PF04679, ATP dependent DNA ligase C terminal re, score 8.6e-11 522373000226 3 probable transmembrane helices predicted for Smlt0054 by TMHMM2.0 at aa 29-51, 58-77 and 81-103 522373000227 putative alcohol dehydrogenase, pseudogene;Similar to N-terminus of Rhizobium meliloti (Sinorhizobium meliloti) AdhA alcohol dehydrogenase (ec 1.1.1.1). UniProt:O31186 (340 aa) fasta scores: E()=1.7e-07, 73.171% id in 41 aa, and to Bradyrhizobium japonicum alcohol dehydrogenase. UniProt:Q89IH9 (341 aa) fasta scores: E()=8.2e-09, 73.171% id in 41 aa; similarity:fasta; with=UniProt:O31186; Rhizobium meliloti (Sinorhizobium meliloti).; adhA; Alcohol dehydrogenase (EC 1.1.1.1).; length=340; id 73.171%; ungapped id 73.171%; E()=1.7e-07; 41 aa overlap; query 4-44; subject 2-42; similarity:fasta; with=UniProt:Q89IH9; Bradyrhizobium japonicum.; Alcohol dehydrogenase.; length=341; id 73.171%; ungapped id 73.171%; E()=8.2e-09; 41 aa overlap; query 4-44; subject 3-43 522373000228 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 2e-39 522373000229 integrase; Provisional; Region: PRK09692 522373000230 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 522373000231 active site 522373000232 Int/Topo IB signature motif; other site 522373000233 HMMPfam hit to PF00589, Phage integrase family, score 3e-07 522373000234 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 522373000235 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 5.7e-25 522373000236 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 522373000237 HMMPfam hit to PF04606, Ogr/Delta-like zinc finger, score 8e-14 522373000238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 522373000239 Toprim domain; Region: Toprim_4; pfam13662 522373000240 active site 522373000241 metal binding site [ion binding]; metal-binding site 522373000242 HMMPfam hit to PF01751, Toprim domain, score 0.0012 522373000243 Domain of unknown function (DUF927); Region: DUF927; pfam06048 522373000244 HMMPfam hit to PF06048, Domain of unknown function (DUF927), score 6.3e-05 522373000245 Phage-related protein [Function unknown]; Region: COG4695; cl01923 522373000246 Phage portal protein; Region: Phage_portal; pfam04860 522373000247 HMMPfam hit to PF04860, Phage portal protein, score 2.9e-60 522373000248 Helix-turn-helix domain; Region: HTH_37; pfam13744 522373000249 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 522373000250 HMMPfam hit to PF05973, Phage derived protein Gp49-like (DUF891), score 6.5e-13 522373000251 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 522373000252 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 522373000253 active site 522373000254 intersubunit interface [polypeptide binding]; other site 522373000255 catalytic residue [active] 522373000256 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 2.8e-80 522373000257 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 522373000258 HMMPfam hit to PF05995, Cysteine dioxygenase type I, score 1.1e-06 522373000259 Transcriptional regulators [Transcription]; Region: PurR; COG1609 522373000260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 522373000261 DNA binding site [nucleotide binding] 522373000262 domain linker motif; other site 522373000263 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 522373000264 putative dimerization interface [polypeptide binding]; other site 522373000265 putative ligand binding site [chemical binding]; other site 522373000266 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.5e-10 522373000267 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2e-10 522373000268 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 522373000269 cofactor binding site; other site 522373000270 metal binding site [ion binding]; metal-binding site 522373000271 HMMPfam hit to PF00351, Biopterin-dependent aromatic amino acid h, score 6.5e-12 522373000272 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 522373000273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373000274 dimerization interface [polypeptide binding]; other site 522373000275 putative DNA binding site [nucleotide binding]; other site 522373000276 putative Zn2+ binding site [ion binding]; other site 522373000277 AsnC family; Region: AsnC_trans_reg; pfam01037 522373000278 HMMPfam hit to PF01037, AsnC family, score 1.3e-29 522373000279 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 522373000280 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 522373000281 nucleophile elbow; other site 522373000282 HMMPfam hit to PF01734, Patatin-like phospholipase, score 4.7e-45 522373000283 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 522373000284 Uncharacterized conserved protein [Function unknown]; Region: COG2013 522373000285 HMMPfam hit to PF01987, Protein of unknown function DUF124, score 1.2e-97 522373000286 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373000287 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373000288 N-terminal plug; other site 522373000289 ligand-binding site [chemical binding]; other site 522373000290 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3e-16 522373000291 HMMPfam hit to PF00593, TonB dependent receptor, score 5.2e-23 522373000292 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 522373000293 active site 522373000294 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 522373000295 HMMPfam hit to PF01569, PAP2 superfamily, score 2.4e-11 522373000296 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 522373000297 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 522373000298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373000299 Walker A/P-loop; other site 522373000300 ATP binding site [chemical binding]; other site 522373000301 Q-loop/lid; other site 522373000302 ABC transporter signature motif; other site 522373000303 Walker B; other site 522373000304 D-loop; other site 522373000305 H-loop/switch region; other site 522373000306 HMMPfam hit to PF00005, ABC transporter score 2.6e-40 522373000307 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 522373000308 Fatty acid desaturase; Region: FA_desaturase; pfam00487 522373000309 Di-iron ligands [ion binding]; other site 522373000310 HMMPfam hit to PF00487, Fatty acid desaturase, score 5.1e-08 522373000311 2 probable transmembrane helices predicted for Smlt0088 by TMHMM2.0 at aa 48-70 and 174-196 522373000312 EF-hand domain pair; Region: EF_hand_5; pfam13499 522373000313 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 522373000314 Ca2+ binding site [ion binding]; other site 522373000315 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 522373000316 Ca2+ binding site [ion binding]; other site 522373000317 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 522373000318 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 522373000319 DNA binding site [nucleotide binding] 522373000320 catalytic residue [active] 522373000321 H2TH interface [polypeptide binding]; other site 522373000322 putative catalytic residues [active] 522373000323 turnover-facilitating residue; other site 522373000324 intercalation triad [nucleotide binding]; other site 522373000325 8OG recognition residue [nucleotide binding]; other site 522373000326 putative reading head residues; other site 522373000327 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 522373000328 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 522373000329 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase N-, score 1.5e-39 522373000330 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycosylase H2, score 3.8e-41 522373000331 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 522373000332 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 522373000333 HMMPfam hit to PF04349, Periplasmic glucan biosynthesis protein, Mdo, score 9.1e-304 522373000334 thymidine kinase; Provisional; Region: PRK04296 522373000335 HMMPfam hit to PF00265, Thymidine kinase, score 1.2e-65 522373000336 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 522373000337 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 522373000338 Sel1-like repeats; Region: SEL1; smart00671 522373000339 HMMPfam hit to PF08238, Sel1 repeat, score 3.3e-05 522373000340 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 522373000341 Part of AAA domain; Region: AAA_19; pfam13245 522373000342 Family description; Region: UvrD_C_2; pfam13538 522373000343 HMMPfam hit to PF00580, UvrD/REP helicase, score 1.3e-183 522373000344 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 522373000345 Protein of unknown function, DUF480; Region: DUF480; cl01209 522373000346 HMMPfam hit to PF04337, Protein of unknown function, DUF480, score 2.9e-84 522373000347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373000348 active site 522373000349 motif I; other site 522373000350 motif II; other site 522373000351 HMMPfam hit to PF03767, HAD superfamily, subfamily IIIB (Acid, score 7.1e-47 522373000352 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 522373000353 active site 522373000354 dimer interface [polypeptide binding]; other site 522373000355 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase / HUMP, score 1e-60 522373000356 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 522373000357 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 522373000358 putative acyl-acceptor binding pocket; other site 522373000359 HMMPfam hit to PF01553, Acyltransferase, score 5.3e-34 522373000360 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 522373000361 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 522373000362 Ligand Binding Site [chemical binding]; other site 522373000363 HMMPfam hit to PF01171, PP-loop family, score 5e-12 522373000364 recombination associated protein; Reviewed; Region: rdgC; PRK00321 522373000365 HMMPfam hit to PF04381, Putative exonuclease, RdgC, score 6.1e-154 522373000366 Protein of unknown function DUF45; Region: DUF45; pfam01863 522373000367 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 3.4e-57 522373000368 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 522373000369 substrate binding site [chemical binding]; other site 522373000370 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 522373000371 substrate binding site [chemical binding]; other site 522373000372 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 522373000373 PAS fold; Region: PAS_3; pfam08447 522373000374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 522373000375 putative active site [active] 522373000376 heme pocket [chemical binding]; other site 522373000377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373000378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373000379 dimer interface [polypeptide binding]; other site 522373000380 phosphorylation site [posttranslational modification] 522373000381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373000382 ATP binding site [chemical binding]; other site 522373000383 Mg2+ binding site [ion binding]; other site 522373000384 G-X-G motif; other site 522373000385 Response regulator receiver domain; Region: Response_reg; pfam00072 522373000386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373000387 active site 522373000388 phosphorylation site [posttranslational modification] 522373000389 intermolecular recognition site; other site 522373000390 dimerization interface [polypeptide binding]; other site 522373000391 HMMPfam hit to PF08447, PAS fold, score 9.3e-07 522373000392 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 6.9e-17 522373000393 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 4.3e-34 522373000394 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.8e-29 522373000395 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 522373000396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373000397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373000398 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 1.4e-06 522373000399 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 2.8e-06 522373000400 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 522373000401 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 522373000402 active site 522373000403 dimer interface [polypeptide binding]; other site 522373000404 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 522373000405 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 522373000406 active site 522373000407 FMN binding site [chemical binding]; other site 522373000408 substrate binding site [chemical binding]; other site 522373000409 3Fe-4S cluster binding site [ion binding]; other site 522373000410 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 522373000411 domain interface; other site 522373000412 HMMPfam hit to PF01493, GXGXG motif, score 3e-94 522373000413 HMMPfam hit to PF01645, Conserved region in glutamate synthas, score 7.2e-220 522373000414 HMMPfam hit to PF04898, Glutamate synthase central domain, score 2.3e-160 522373000415 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 1.3e-169 522373000416 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 522373000417 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 522373000418 active site 522373000419 DNA binding site [nucleotide binding] 522373000420 Int/Topo IB signature motif; other site 522373000421 catalytic residues [active] 522373000422 short chain dehydrogenase; Provisional; Region: PRK06701 522373000423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373000424 NAD(P) binding site [chemical binding]; other site 522373000425 active site 522373000426 HMMPfam hit to PF00106, short chain dehydrogenase, score 9.5e-22 522373000427 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373000428 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373000429 HMMPfam hit to PF00144, Beta-lactamase, score 1.6e-68 522373000430 Penicillinase repressor; Region: Pencillinase_R; pfam03965 522373000431 HMMPfam hit to PF03965, Penicillinase repressor, score 1.1e-37 522373000432 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 522373000433 4 probable transmembrane helices predicted for Smlt0117 by TMHMM2.0 at aa 15-34, 46-68, 109-131 and 315-337 522373000434 HMMPfam hit to PF05569, BlaR1 peptidase M56, score 5.1e-30 522373000435 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 522373000436 RNase_H superfamily; Region: RNase_H_2; pfam13482 522373000437 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 522373000438 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373000439 ATP binding site [chemical binding]; other site 522373000440 putative Mg++ binding site [ion binding]; other site 522373000441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373000442 nucleotide binding region [chemical binding]; other site 522373000443 ATP-binding site [chemical binding]; other site 522373000444 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 522373000445 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.5e-14 522373000446 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 3.6e-39 522373000447 3 probable transmembrane helices predicted for Smlt0123 by TMHMM2.0 at aa 5-23, 36-58 and 581-598 522373000448 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 522373000449 3 probable transmembrane helices predicted for Smlt0124 by TMHMM2.0 at aa 17-39, 43-62 and 120-142 522373000450 HMMPfam hit to PF07584, Protein of unknown function (DUF1550), score 9.9e-15 522373000451 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 522373000452 Protein of unknown function DUF58; Region: DUF58; pfam01882 522373000453 HMMPfam hit to PF01882, Protein of unknown function DUF58, score 0.0018 522373000454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373000455 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 522373000456 Walker A motif; other site 522373000457 ATP binding site [chemical binding]; other site 522373000458 Walker B motif; other site 522373000459 arginine finger; other site 522373000460 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 5.9e-11 522373000461 HMMPfam hit to PF07726, ATPase family associated with various cellul, score 1.1e-82 522373000462 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 522373000463 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 522373000464 HMMPfam hit to PF01523, Putative modulator of DNA gyrase, score 3.3e-12 522373000465 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 522373000466 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 522373000467 HMMPfam hit to PF01523, Putative modulator of DNA gyrase, score 2.3e-48 522373000468 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 522373000469 HMMPfam hit to PF01523, Putative modulator of DNA gyrase, score 1.1e-54 522373000470 Protein of unknown function (DUF938); Region: DUF938; pfam06080 522373000471 HMMPfam hit to PF06080, Protein of unknown function (DUF938), score 8.5e-94 522373000472 HipA N-terminal domain; Region: Couple_hipA; pfam13657 522373000473 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 522373000474 HipA-like N-terminal domain; Region: HipA_N; pfam07805 522373000475 HipA-like C-terminal domain; Region: HipA_C; pfam07804 522373000476 HMMPfam hit to PF07804, HipA-like C-terminal domain, score 4.3e-36 522373000477 HMMPfam hit to PF07805, HipA-like N-terminal domain, score 6.6e-19 522373000478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373000479 non-specific DNA binding site [nucleotide binding]; other site 522373000480 salt bridge; other site 522373000481 sequence-specific DNA binding site [nucleotide binding]; other site 522373000482 HMMPfam hit to PF01381, Helix-turn-helix, score 9.9e-13 522373000483 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 522373000484 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 522373000485 dimer interface [polypeptide binding]; other site 522373000486 PYR/PP interface [polypeptide binding]; other site 522373000487 TPP binding site [chemical binding]; other site 522373000488 substrate binding site [chemical binding]; other site 522373000489 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 522373000490 TPP-binding site; other site 522373000491 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 522373000492 HMMPfam hit to PF01558, Pyruvate ferredoxin/flavodoxin oxidoreductas, score 9.5e-06 522373000493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 522373000494 binding surface 522373000495 TPR motif; other site 522373000496 Ycf46; Provisional; Region: ycf46; CHL00195 522373000497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373000498 Walker A motif; other site 522373000499 ATP binding site [chemical binding]; other site 522373000500 Walker B motif; other site 522373000501 arginine finger; other site 522373000502 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 3.9e-51 522373000503 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 522373000504 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 522373000505 P-loop; other site 522373000506 Magnesium ion binding site [ion binding]; other site 522373000507 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 522373000508 catalytic core [active] 522373000509 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 1.9e-20 522373000510 YceI-like domain; Region: YceI; pfam04264 522373000511 HMMPfam hit to PF04264, YceI like family, score 1.6e-15 522373000512 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 522373000513 PLD-like domain; Region: PLDc_2; pfam13091 522373000514 putative active site [active] 522373000515 catalytic site [active] 522373000516 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 522373000517 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 522373000518 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 522373000519 putative active site [active] 522373000520 catalytic site [active] 522373000521 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.0019 522373000522 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.0038 522373000523 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 522373000524 CoenzymeA binding site [chemical binding]; other site 522373000525 subunit interaction site [polypeptide binding]; other site 522373000526 PHB binding site; other site 522373000527 HMMPfam hit to PF03061, Thioesterase superfamily, score 6.6e-21 522373000528 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 522373000529 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 522373000530 putative acyl-acceptor binding pocket; other site 522373000531 1 probable transmembrane helix predicted for Smlt0144 by TMHMM2.0 at aa 31-53 522373000532 HMMPfam hit to PF01553, Acyltransferase, score 9.2e-23 522373000533 putative hydrolase; Provisional; Region: PRK10985 522373000534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373000535 binding surface 522373000536 TPR motif; other site 522373000537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373000538 binding surface 522373000539 TPR motif; other site 522373000540 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 0.089 522373000541 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 4.5e-08 522373000542 HMMPfam hit to PF07721, Tetratricopeptide repeat, score 0.011 522373000543 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0022 522373000544 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 522373000545 substrate binding site [chemical binding]; other site 522373000546 HMMPfam hit to PF01161, Phosphatidylethanolamine-binding protein, score 1.5e-07 522373000547 META domain; Region: META; pfam03724 522373000548 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 522373000549 HMMPfam hit to PF03724, Domain of unknown function (306), score 1.4e-24 522373000550 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 522373000551 7 probable transmembrane helices predicted for Smlt0150 by TMHMM2.0 at aa 41-58, 78-95, 105-123, 136-157, 177-199, 212-234 and 244-263 522373000552 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 2.1e-100 522373000553 glutamine synthetase; Provisional; Region: glnA; PRK09469 522373000554 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 522373000555 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 522373000556 HMMPfam hit to PF03951, Glutamine synthetase, beta-Grasp domain, score 1.3e-43 522373000557 HMMPfam hit to PF00120, Glutamine synthetase, catalytic domain, score 1.3e-164 522373000558 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 522373000559 Nitrogen regulatory protein P-II; Region: P-II; smart00938 522373000560 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 1.8e-67 522373000561 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 522373000562 12 probable transmembrane helices predicted for Smlt0153 by TMHMM2.0 at aa 13-32, 77-99, 106-128, 168-190, 197-219, 234-253, 266-285, 295-317, 329-351, 355-372, 385-407 and 422-444 522373000563 HMMPfam hit to PF00909, Ammonium Transporter Family, score 9.9e-162 522373000564 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 522373000565 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 522373000566 amidase catalytic site [active] 522373000567 Zn binding residues [ion binding]; other site 522373000568 substrate binding site [chemical binding]; other site 522373000569 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 2.3e-32 522373000570 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 522373000571 MltA specific insert domain; Region: MltA; smart00925 522373000572 3D domain; Region: 3D; pfam06725 522373000573 HMMPfam hit to PF03562, MltA N-terminal domain, score 1.3e-110 522373000574 HMMPfam hit to PF06725, 3D domain, score 1.2e-34 522373000575 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373000576 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373000577 N-terminal plug; other site 522373000578 ligand-binding site [chemical binding]; other site 522373000579 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.2e-19 522373000580 HMMPfam hit to PF00593, TonB dependent receptor, score 2.5e-20 522373000581 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 522373000582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373000583 ATP binding site [chemical binding]; other site 522373000584 Mg2+ binding site [ion binding]; other site 522373000585 G-X-G motif; other site 522373000586 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.8e-13 522373000587 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 7.7e-32 522373000588 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 522373000589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373000590 active site 522373000591 phosphorylation site [posttranslational modification] 522373000592 intermolecular recognition site; other site 522373000593 dimerization interface [polypeptide binding]; other site 522373000594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373000595 Walker A motif; other site 522373000596 ATP binding site [chemical binding]; other site 522373000597 Walker B motif; other site 522373000598 arginine finger; other site 522373000599 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.3e-27 522373000600 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.2e-141 522373000601 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 2.5e-09 522373000602 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 522373000603 active site 522373000604 Cu2+ binding site [ion binding]; other site 522373000605 E-class dimer interface [polypeptide binding]; other site 522373000606 Zn2+ binding site [ion binding]; other site 522373000607 P-class dimer interface [polypeptide binding]; other site 522373000608 HMMPfam hit to PF00080, Copper/zinc superoxide dismutase (SODC), score 4.3e-26 522373000609 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 522373000610 E-class dimer interface [polypeptide binding]; other site 522373000611 P-class dimer interface [polypeptide binding]; other site 522373000612 active site 522373000613 Cu2+ binding site [ion binding]; other site 522373000614 Zn2+ binding site [ion binding]; other site 522373000615 HMMPfam hit to PF00080, Copper/zinc superoxide dismutase (SODC), score 7e-45 522373000616 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373000617 1 probable transmembrane helix predicted for Smlt0162 by TMHMM2.0 at aa 21-43 522373000618 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 522373000619 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 522373000620 dimer interface [polypeptide binding]; other site 522373000621 active site 522373000622 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 3.6e-54 522373000623 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 1e-35 522373000624 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 522373000625 HemY protein N-terminus; Region: HemY_N; pfam07219 522373000626 HMMPfam hit to PF07219, HemY protein N-terminus, score 9e-28 522373000627 2 probable transmembrane helices predicted for Smlt0165 by TMHMM2.0 at aa 7-26 and 51-73 522373000628 HemX; Region: HemX; pfam04375 522373000629 HMMPfam hit to PF04375, HemX, score 1.6e-05 522373000630 1 probable transmembrane helix predicted for Smlt0166 by TMHMM2.0 at aa 15-37 522373000631 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 522373000632 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 522373000633 active site 522373000634 HMMPfam hit to PF02602, Uroporphyrinogen-III synthase HemD, score 4.5e-07 522373000635 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 522373000636 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 522373000637 active site residue [active] 522373000638 1 probable transmembrane helix predicted for Smlt0170 by TMHMM2.0 at aa 15-32 522373000639 HMMPfam hit to PF00581, Rhodanese-like domain, score 4.6e-15 522373000640 preprotein translocase subunit SecB; Validated; Region: PRK05751 522373000641 SecA binding site; other site 522373000642 Preprotein binding site; other site 522373000643 HMMPfam hit to PF02556, Preprotein translocase subunit SecB, score 6.2e-50 522373000644 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 522373000645 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 522373000646 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 522373000647 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD b, score 0.00014 522373000648 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 4.7e-81 522373000649 HMMPfam hit to PF03807, NADP oxidoreductase coenzyme F420-depe, score 0.0021 522373000650 HMMPfam hit to PF02558, Ketopantoate reductase PanE/ApbA, score 0.00039 522373000651 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate deh, score 3.7e-68 522373000652 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 522373000653 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 522373000654 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 522373000655 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 522373000656 Sodium Bile acid symporter family; Region: SBF; cl17470 522373000657 10 probable transmembrane helices predicted for Smlt0176 by TMHMM2.0 at aa 13-35, 45-62, 83-102, 117-139, 152-174, 184-206, 218-240, 250-272, 285-307 and 312-334 522373000658 HMMPfam hit to PF01758, Sodium Bile acid symporter family, score 1.5e-32 522373000659 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 522373000660 Low molecular weight phosphatase family; Region: LMWPc; cl00105 522373000661 active site 522373000662 HMMPfam hit to PF01451, Low molecular weight phosphotyrosine protein, score 9.6e-24 522373000663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373000664 dimerization interface [polypeptide binding]; other site 522373000665 putative DNA binding site [nucleotide binding]; other site 522373000666 putative Zn2+ binding site [ion binding]; other site 522373000667 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 6.1e-06 522373000668 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 522373000669 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373000670 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 2.6e-51 522373000671 3 probable transmembrane helices predicted for Smlt0180 by TMHMM2.0 at aa 13-32, 63-80 and 90-112 522373000672 1 probable transmembrane helix predicted for Smlt0182 by TMHMM2.0 at aa 10-32 522373000673 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 522373000674 sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273 522373000675 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 522373000676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373000677 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 522373000678 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 4.8e-14 522373000679 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 522373000680 HMMPfam hit to PF04261, Dyp-type peroxidase family, score 2e-105 522373000681 1 probable transmembrane helix predicted for Smlt0188 by TMHMM2.0 at aa 13-32 522373000682 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 522373000683 5 probable transmembrane helices predicted for Smlt0189 by TMHMM2.0 at aa 4-21, 26-43, 53-70, 138-157 and 161-183 522373000684 HMMPfam hit to PF04973, Nicotinamide mononucleotide transport, score 6.4e-09 522373000685 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 522373000686 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373000687 N-terminal plug; other site 522373000688 ligand-binding site [chemical binding]; other site 522373000689 HMMPfam hit to PF00593, TonB dependent receptor, score 4.3e-20 522373000690 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5e-15 522373000691 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 522373000692 active site 522373000693 ATP binding site [chemical binding]; other site 522373000694 substrate binding site [chemical binding]; other site 522373000695 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 1.8e-16 522373000696 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 3.1e-06 522373000697 1 probable transmembrane helix predicted for Smlt0192 by TMHMM2.0 at aa 7-29 522373000698 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 522373000699 N-acetyl-D-glucosamine binding site [chemical binding]; other site 522373000700 catalytic residue [active] 522373000701 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 522373000702 HMMPfam hit to PF01471, Putative peptidoglycan binding domain, score 6.8e-20 522373000703 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373000704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373000705 active site 522373000706 phosphorylation site [posttranslational modification] 522373000707 intermolecular recognition site; other site 522373000708 dimerization interface [polypeptide binding]; other site 522373000709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373000710 DNA binding residues [nucleotide binding] 522373000711 dimerization interface [polypeptide binding]; other site 522373000712 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 4.1e-14 522373000713 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.7e-26 522373000714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 522373000715 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 522373000716 substrate binding pocket [chemical binding]; other site 522373000717 membrane-bound complex binding site; other site 522373000718 hinge residues; other site 522373000719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 522373000720 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 522373000721 substrate binding pocket [chemical binding]; other site 522373000722 membrane-bound complex binding site; other site 522373000723 hinge residues; other site 522373000724 PAS fold; Region: PAS_3; pfam08447 522373000725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373000726 putative active site [active] 522373000727 heme pocket [chemical binding]; other site 522373000728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373000729 dimer interface [polypeptide binding]; other site 522373000730 phosphorylation site [posttranslational modification] 522373000731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373000732 ATP binding site [chemical binding]; other site 522373000733 Mg2+ binding site [ion binding]; other site 522373000734 G-X-G motif; other site 522373000735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373000736 active site 522373000737 phosphorylation site [posttranslational modification] 522373000738 intermolecular recognition site; other site 522373000739 dimerization interface [polypeptide binding]; other site 522373000740 1 probable transmembrane helix predicted for Smlt0196 by TMHMM2.0 at aa 26-48 522373000741 HMMPfam hit to PF08447, PAS fold, score 9.4e-05 522373000742 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 4.9e-24 522373000743 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 9.6e-40 522373000744 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.2e-28 522373000745 HMMPfam hit to PF01627, Hpt domain, score 8.5e-06 522373000746 Cytochrome c; Region: Cytochrom_C; cl11414 522373000747 HMMPfam hit to PF00034, Cytochrome c, score 2e-12 522373000748 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 522373000749 hydroxyglutarate oxidase; Provisional; Region: PRK11728 522373000750 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 522373000751 HMMPfam hit to PF05187, Electron transfer flavoprotein-ubiquinone ox, score 7.1e-105 522373000752 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 9.6e-05 522373000753 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 522373000754 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 522373000755 active site 522373000756 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 1.2e-20 522373000757 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 1.7e-28 522373000758 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 2.3e-36 522373000759 HMMPfam hit to PF08028, Acyl-CoA dehydrogenase, C-terminal doma, score 7.4e-06 522373000760 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 522373000761 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 3.8e-45 522373000762 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 522373000763 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 522373000764 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 522373000765 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 522373000766 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 522373000767 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 2.6e-06 522373000768 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 4.4e-40 522373000769 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 4.7e-28 522373000770 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 522373000771 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 522373000772 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 522373000773 dimer interface [polypeptide binding]; other site 522373000774 active site 522373000775 CoA binding pocket [chemical binding]; other site 522373000776 HMMPfam hit to PF08541, 3-Oxoacyl-[acyl-carrier-protein (ACP)], score 1.1e-17 522373000777 haloalkane dehalogenase; Provisional; Region: PRK00870 522373000778 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1e-20 522373000779 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 522373000780 HMMPfam hit to PF03692, Uncharacterised protein family (UPF0153), score 7.9e-20 522373000781 peptide synthase; Provisional; Region: PRK09274 522373000782 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 522373000783 acyl-activating enzyme (AAE) consensus motif; other site 522373000784 putative AMP binding site [chemical binding]; other site 522373000785 putative active site [active] 522373000786 putative CoA binding site [chemical binding]; other site 522373000787 HMMPfam hit to PF00501, AMP-binding enzyme, score 4e-56 522373000788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373000789 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 522373000790 NAD(P) binding site [chemical binding]; other site 522373000791 active site 522373000792 HMMPfam hit to PF04321, RmlD substrate binding domain, score 4.4e-05 522373000793 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 0.00064 522373000794 HMMPfam hit to PF05368, NmrA-like family, score 0.00041 522373000795 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 2.2e-26 522373000796 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 1e-60 522373000797 HMMPfam hit to PF07993, Male sterility protein, score 2.5e-11 522373000798 HMMPfam hit to PF07043, Protein of unknown function (DUF1328), score 7.5e-24 522373000799 2 probable transmembrane helices predicted for Smlt0210 by TMHMM2.0 at aa 2-24 and 28-47 522373000800 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 522373000801 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 522373000802 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 522373000803 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 2.1e-114 522373000804 HMMPfam hit to PF08443, RimK-like ATP-grasp domain, score 0.00041 522373000805 HMMPfam hit to PF02655, ATP-grasp domain, score 0.0039 522373000806 HMMPfam hit to PF02222, ATP-grasp domain, score 3.5e-08 522373000807 HMMPfam hit to PF01820, D-ala D-ala ligase N-terminus, score 4.3e-59 522373000808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 522373000809 SCP-2 sterol transfer family; Region: SCP2; pfam02036 522373000810 HMMPfam hit to PF06843, Protein of unknown function (DUF1243), score 7.5e-61 522373000811 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 522373000812 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 522373000813 HMMPfam hit to PF03109, ABC1 family, score 2.2e-46 522373000814 2 probable transmembrane helices predicted for Smlt0213 by TMHMM2.0 at aa 501-520 and 530-549 522373000815 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 522373000816 putative trimer interface [polypeptide binding]; other site 522373000817 putative CoA binding site [chemical binding]; other site 522373000818 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1e+02 522373000819 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.4 522373000820 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.15 522373000821 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 9 522373000822 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 41 522373000823 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 17 522373000824 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 522373000825 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 522373000826 DXD motif; other site 522373000827 4 probable transmembrane helices predicted for Smlt0216 by TMHMM2.0 at aa 176-198, 266-288, 303-325 and 332-354 522373000828 HMMPfam hit to PF00535, Glycosyl transferase family, score 6.8e-26 522373000829 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 522373000830 HMMPfam hit to PF02585, GlcNAc-PI de-N-acetylase, score 3.8e-32 522373000831 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 522373000832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373000833 S-adenosylmethionine binding site [chemical binding]; other site 522373000834 HMMPfam hit to PF01596, O-methyltransferase, score 1.2e-13 522373000835 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 522373000836 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 522373000837 active site 522373000838 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 5.1e-26 522373000839 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 522373000840 hypothetical protein; Provisional; Region: PRK09256 522373000841 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 522373000842 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 3.2e-28 522373000843 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 522373000844 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 522373000845 putative acyl-acceptor binding pocket; other site 522373000846 HMMPfam hit to PF01553, Acyltransferase, score 3.7e-07 522373000847 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 522373000848 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 522373000849 active site 522373000850 Zn binding site [ion binding]; other site 522373000851 HMMPfam hit to PF01432, Peptidase family M3, score 1.3e-163 522373000852 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 522373000853 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 522373000854 Catalytic site [active] 522373000855 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 522373000856 HMMPfam hit to PF00717, Peptidase S24-like, score 2e-19 522373000857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373000858 putative substrate translocation pore; other site 522373000859 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 522373000860 12 probable transmembrane helices predicted for Smlt0227 by TMHMM2.0 at aa 35-57, 70-92, 99-121, 125-147, 154-176, 186-208, 236-258, 268-290, 303-322, 326-348, 361-383 and 387-409 522373000861 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.2e-44 522373000862 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373000863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373000864 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 522373000865 dimerization interface [polypeptide binding]; other site 522373000866 substrate binding pocket [chemical binding]; other site 522373000867 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-47 522373000868 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.3e-09 522373000869 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373000870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373000871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 522373000872 dimerization interface [polypeptide binding]; other site 522373000873 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.7e-55 522373000874 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.3e-22 522373000875 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 522373000876 malate synthase A; Region: malate_syn_A; TIGR01344 522373000877 active site 522373000878 HMMPfam hit to PF01274, Malate synthase, score 8.3e-262 522373000879 isocitrate lyase; Provisional; Region: PRK15063 522373000880 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 522373000881 tetramer interface [polypeptide binding]; other site 522373000882 active site 522373000883 Mg2+/Mn2+ binding site [ion binding]; other site 522373000884 HMMPfam hit to PF00463, Isocitrate lyase family, score 4.1e-237 522373000885 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 522373000886 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 522373000887 ligand binding site [chemical binding]; other site 522373000888 flexible hinge region; other site 522373000889 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373000890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373000891 metal binding site [ion binding]; metal-binding site 522373000892 active site 522373000893 I-site; other site 522373000894 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 5.1e-22 522373000895 HMMPfam hit to PF00990, GGDEF domain, score 1.1e-45 522373000896 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 522373000897 cyclase homology domain; Region: CHD; cd07302 522373000898 dimer interface [polypeptide binding]; other site 522373000899 nucleotidyl binding site; other site 522373000900 metal binding site [ion binding]; metal-binding site 522373000901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373000902 binding surface 522373000903 TPR motif; other site 522373000904 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0027 522373000905 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 522373000906 putative FMN binding site [chemical binding]; other site 522373000907 NADPH bind site [chemical binding]; other site 522373000908 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 522373000909 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 522373000910 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 522373000911 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 522373000912 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 522373000913 carboxyltransferase (CT) interaction site; other site 522373000914 biotinylation site [posttranslational modification]; other site 522373000915 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 1.7e-18 522373000916 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 5.6e-47 522373000917 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 1.8e-101 522373000918 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase,, score 0.0012 522373000919 HMMPfam hit to PF02222, ATP-grasp domain, score 0.0025 522373000920 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 2.8e-48 522373000921 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 522373000922 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 522373000923 HMMPfam hit to PF01039, Carboxyl transferase domain, score 1.5e-221 522373000924 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 522373000925 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 522373000926 active site 522373000927 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 1.8e-53 522373000928 HMMPfam hit to PF08028, Acyl-CoA dehydrogenase, C-terminal doma, score 1.6e-06 522373000929 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 2.4e-28 522373000930 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 1e-41 522373000931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373000932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373000933 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 3.5e-14 522373000934 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 522373000935 1 probable transmembrane helix predicted for Smlt0241 by TMHMM2.0 at aa 12-34 522373000936 HMMPfam hit to PF00034, Cytochrome c, score 2.9e-06 522373000937 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 522373000938 putative active site [active] 522373000939 putative catalytic site [active] 522373000940 putative Mg binding site IVb [ion binding]; other site 522373000941 putative phosphate binding site [ion binding]; other site 522373000942 putative DNA binding site [nucleotide binding]; other site 522373000943 putative Mg binding site IVa [ion binding]; other site 522373000944 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 5.5e-17 522373000945 10 probable transmembrane helices predicted for Smlt0244 by TMHMM2.0 at aa 4-21, 34-51, 61-83, 96-113, 118-135, 148-165, 175-197, 210-229, 239-261 and 268-285 522373000946 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 0.0021 522373000947 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 522373000948 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373000949 Predicted ATPase [General function prediction only]; Region: COG1485 522373000950 HMMPfam hit to PF03969, AFG1-like ATPase, score 2.3e-146 522373000951 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 522373000952 ATP cone domain; Region: ATP-cone; pfam03477 522373000953 Class I ribonucleotide reductase; Region: RNR_I; cd01679 522373000954 active site 522373000955 dimer interface [polypeptide binding]; other site 522373000956 catalytic residues [active] 522373000957 effector binding site; other site 522373000958 R2 peptide binding site; other site 522373000959 HMMPfam hit to PF03477, ATP cone domain, score 4.4e-08 522373000960 HMMPfam hit to PF00317, Ribonucleotide reductase, all-alpha d, score 1.6e-23 522373000961 HMMPfam hit to PF02867, Ribonucleotide reductase, barrel doma, score 1.3e-226 522373000962 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 522373000963 dimer interface [polypeptide binding]; other site 522373000964 putative radical transfer pathway; other site 522373000965 diiron center [ion binding]; other site 522373000966 tyrosyl radical; other site 522373000967 HMMPfam hit to PF00268, Ribonucleotide reductase, small chain, score 2.4e-48 522373000968 1 probable transmembrane helix predicted for Smlt0248 by TMHMM2.0 at aa 169-191 522373000969 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 522373000970 HMMPfam hit to PF01810, LysE type translocator, score 2.7e-29 522373000971 4 probable transmembrane helices predicted for Smlt0250 by TMHMM2.0 at aa 7-29, 44-66, 117-139 and 159-181 522373000972 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 522373000973 HMMPfam hit to PF03061, Thioesterase superfamily, score 7e-20 522373000974 NAD-dependent deacetylase; Provisional; Region: PRK05333 522373000975 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 522373000976 NAD+ binding site [chemical binding]; other site 522373000977 substrate binding site [chemical binding]; other site 522373000978 Zn binding site [ion binding]; other site 522373000979 HMMPfam hit to PF02146, Sir2 family, score 1.4e-55 522373000980 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 522373000981 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 522373000982 active site 522373000983 FMN binding site [chemical binding]; other site 522373000984 substrate binding site [chemical binding]; other site 522373000985 homotetramer interface [polypeptide binding]; other site 522373000986 catalytic residue [active] 522373000987 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 4.1e-68 522373000988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373000989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373000990 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373000991 putative effector binding pocket; other site 522373000992 dimerization interface [polypeptide binding]; other site 522373000993 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.4e-39 522373000994 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.3e-17 522373000995 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 522373000996 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 522373000997 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 522373000998 putative active site [active] 522373000999 putative substrate binding site [chemical binding]; other site 522373001000 putative cosubstrate binding site; other site 522373001001 catalytic site [active] 522373001002 HMMPfam hit to PF01842, ACT domain, score 1.4e-09 522373001003 HMMPfam hit to PF00551, Formyl transferase, score 1.3e-41 522373001004 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 522373001005 catalytic triad [active] 522373001006 metal binding site [ion binding]; metal-binding site 522373001007 conserved cis-peptide bond; other site 522373001008 HMMPfam hit to PF00857, Isochorismatase family, score 9.8e-11 522373001009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 522373001010 HMMPfam hit to PF02677, Uncharacterized BCR, COG1636, score 2.1e-125 522373001011 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 522373001012 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 522373001013 active site 522373001014 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase (NAPRTa, score 2.4e-113 522373001015 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 522373001016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 522373001017 active site 522373001018 nucleotide binding site [chemical binding]; other site 522373001019 HIGH motif; other site 522373001020 KMSKS motif; other site 522373001021 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 522373001022 nudix motif; other site 522373001023 HMMPfam hit to PF00293, NUDIX domain, score 6e-26 522373001024 HMMPfam hit to PF01467, Cytidylyltransferase, score 5.8e-06 522373001025 HMMPfam hit to PF01734, Patatin-like phospholipase, score 0.00031 522373001026 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 522373001027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373001028 sequence-specific DNA binding site [nucleotide binding]; other site 522373001029 salt bridge; other site 522373001030 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 522373001031 Domain of unknown function (DUF955); Region: DUF955; pfam06114 522373001032 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 522373001033 HMMPfam hit to PF06114, Domain of unknown function (DUF955), score 2.3e-21 522373001034 HMMPfam hit to PF01381, Helix-turn-helix, score 2.4e-11 522373001035 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 522373001036 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 522373001037 tetrameric interface [polypeptide binding]; other site 522373001038 NAD binding site [chemical binding]; other site 522373001039 catalytic residues [active] 522373001040 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.3e-181 522373001041 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 522373001042 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 522373001043 active site 522373001044 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 2.8e-21 522373001045 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 4.1e-28 522373001046 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 3.1e-66 522373001047 HMMPfam hit to PF08028, Acyl-CoA dehydrogenase, C-terminal doma, score 8.1e-22 522373001048 enoyl-CoA hydratase; Provisional; Region: PRK09076 522373001049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 522373001050 substrate binding site [chemical binding]; other site 522373001051 oxyanion hole (OAH) forming residues; other site 522373001052 trimer interface [polypeptide binding]; other site 522373001053 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 2.7e-41 522373001054 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 522373001055 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 522373001056 substrate binding site [chemical binding]; other site 522373001057 oxyanion hole (OAH) forming residues; other site 522373001058 trimer interface [polypeptide binding]; other site 522373001059 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 522373001060 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 7.5e-11 522373001061 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 522373001062 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 522373001063 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 3.6e-83 522373001064 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 522373001065 HMMPfam hit to PF02566, OsmC-like protein, score 2.2e-33 522373001066 Cation efflux family; Region: Cation_efflux; cl00316 522373001067 HMMPfam hit to PF01545, Cation efflux family, score 1.3e-08 522373001068 6 probable transmembrane helices predicted for Smlt0270 by TMHMM2.0 at aa 16-38, 48-70, 89-111, 126-148, 168-190 and 195-217 522373001069 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 522373001070 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 522373001071 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 522373001072 HMMPfam hit to PF01471, Putative peptidoglycan binding domain, score 6.6e-11 522373001073 HMMPfam hit to PF01471, Putative peptidoglycan binding domain, score 1.6e-16 522373001074 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 522373001075 HMMPfam hit to PF07007, Protein of unknown function (DUF1311), score 3.2e-05 522373001076 1 probable transmembrane helix predicted for Smlt0274 by TMHMM2.0 at aa 13-35 522373001077 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 522373001078 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 522373001079 FMN binding site [chemical binding]; other site 522373001080 active site 522373001081 catalytic residues [active] 522373001082 substrate binding site [chemical binding]; other site 522373001083 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 3e-101 522373001084 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373001085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373001086 active site 522373001087 phosphorylation site [posttranslational modification] 522373001088 intermolecular recognition site; other site 522373001089 dimerization interface [polypeptide binding]; other site 522373001090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373001091 DNA binding site [nucleotide binding] 522373001092 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.6e-35 522373001093 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.6e-23 522373001094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 522373001095 dimer interface [polypeptide binding]; other site 522373001096 phosphorylation site [posttranslational modification] 522373001097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373001098 ATP binding site [chemical binding]; other site 522373001099 Mg2+ binding site [ion binding]; other site 522373001100 G-X-G motif; other site 522373001101 2 probable transmembrane helices predicted for Smlt0278 by TMHMM2.0 at aa 23-45 and 189-211 522373001102 HMMPfam hit to PF00672, HAMP domain, score 1.3e-05 522373001103 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.0015 522373001104 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.3e-25 522373001105 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 522373001106 HMMPfam hit to PF06167, Protein of unknown function (DUF980), score 2.3e-112 522373001107 1 probable transmembrane helix predicted for Smlt0281 by TMHMM2.0 at aa 7-26 522373001108 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 522373001109 Biotin operon repressor [Transcription]; Region: BirA; COG1654 522373001110 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 522373001111 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 522373001112 HMMPfam hit to PF08279, HTH domain, score 2.6e-11 522373001113 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 4e-13 522373001114 HMMPfam hit to PF02237, Biotin protein ligase C terminal domain, score 3.5e-08 522373001115 pantothenate kinase; Reviewed; Region: PRK13327 522373001116 HMMPfam hit to PF03309, Bordetella pertussis Bvg accessory fac, score 1.7e-18 522373001117 Sporulation related domain; Region: SPOR; pfam05036 522373001118 1 probable transmembrane helix predicted for Smlt0284 by TMHMM2.0 at aa 5-24 522373001119 HMMPfam hit to PF05036, Sporulation related domain, score 7.1e-07 522373001120 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 522373001121 active site 522373001122 catalytic residues [active] 522373001123 DNA binding site [nucleotide binding] 522373001124 Int/Topo IB signature motif; other site 522373001125 HMMPfam hit to PF00589, Phage integrase family, score 0.042 522373001126 Protein of unknown function (DUF983); Region: DUF983; cl02211 522373001127 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 522373001128 active site 522373001129 metal binding site [ion binding]; metal-binding site 522373001130 interdomain interaction site; other site 522373001131 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 522373001132 HMMPfam hit to PF04606, Ogr/Delta-like zinc finger, score 1.3e-10 522373001133 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 522373001134 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 522373001135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373001136 non-specific DNA binding site [nucleotide binding]; other site 522373001137 salt bridge; other site 522373001138 sequence-specific DNA binding site [nucleotide binding]; other site 522373001139 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 522373001140 tail protein; Provisional; Region: D; PHA02561 522373001141 HMMPfam hit to PF05954, Phage late control gene D protein (GPD), score 6.2e-167 522373001142 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 522373001143 HMMPfam hit to PF06995, Phage P2 GpU, score 6.4e-54 522373001144 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 522373001145 2 probable transmembrane helices predicted for Smlt0301 by TMHMM2.0 at aa 537-559 and 607-629 522373001146 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 522373001147 HMMPfam hit to PF06528, Phage P2 GpE, score 3.5e-13 522373001148 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 522373001149 HMMPfam hit to PF06158, Phage tail protein E, score 2.5e-44 522373001150 major tail tube protein; Provisional; Region: FII; PHA02600 522373001151 HMMPfam hit to PF04985, Phage tail tube protein FII, score 9e-86 522373001152 major tail sheath protein; Provisional; Region: FI; PHA02560 522373001153 HMMPfam hit to PF04984, Phage tail sheath protein, score 1.6e-132 522373001154 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 522373001155 HMMPfam hit to PF04965, GPW / gp25 family, score 8.2e-42 522373001156 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 522373001157 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 522373001158 HMMPfam hit to PF04717, Phage-related baseplate assembly protein, score 6.7e-48 522373001159 Phage Tail Collar Domain; Region: Collar; pfam07484 522373001160 HMMPfam hit to PF07484, Phage Tail Collar Domain, score 2.4e-17 522373001161 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 522373001162 Baseplate J-like protein; Region: Baseplate_J; cl01294 522373001163 HMMPfam hit to PF04865, Baseplate J-like protein, score 1.6e-76 522373001164 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 522373001165 HMMPfam hit to PF05069, Phage virion morphogenesis family, score 8.3e-41 522373001166 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 522373001167 HMMPfam hit to PF06891, P2 phage tail completion protein R (GpR), score 5.2e-63 522373001168 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 522373001169 Protein of unknown function (DUF754); Region: DUF754; pfam05449 522373001170 HMMPfam hit to PF05449, Protein of unknown function (DUF754), score 1e-23 522373001171 3 probable transmembrane helices predicted for Smlt0316 by TMHMM2.0 at aa 4-23, 36-58 and 62-79 522373001172 3 probable transmembrane helices predicted for Smlt0317 by TMHMM2.0 at aa 20-42, 54-72 and 77-99 522373001173 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 522373001174 HMMPfam hit to PF05489, Phage Tail Protein X, score 2.8e-25 522373001175 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 522373001176 HMMPfam hit to PF05926, Phage head completion protein (GPL), score 1.2e-60 522373001177 terminase endonuclease subunit; Provisional; Region: M; PHA02537 522373001178 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 522373001179 HMMPfam hit to PF05944, Phage small terminase subunit, score 7.2e-65 522373001180 capsid protein; Provisional; Region: N; PHA02538 522373001181 HMMPfam hit to PF05125, Phage major capsid protein, P2 family, score 4.1e-195 522373001182 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 522373001183 HMMPfam hit to PF05929, Phage capsid scaffolding protein (GPO), score 7.7e-114 522373001184 terminase ATPase subunit; Provisional; Region: P; PHA02535 522373001185 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 522373001186 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 522373001187 HMMPfam hit to PF06056, Putative ATPase subunit of terminase (gpP, score 6.1e-31 522373001188 HMMPfam hit to PF03237, Terminase-like family, score 1.4e-156 522373001189 Phage-related protein [Function unknown]; Region: COG4695; cl01923 522373001190 Phage portal protein; Region: Phage_portal; pfam04860 522373001191 HMMPfam hit to PF04860, Phage portal protein, score 2.3e-57 522373001192 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 522373001193 DNA methylase; Region: N6_N4_Mtase; pfam01555 522373001194 HMMPfam hit to PF01555, DNA methylase, score 1.8e-20 522373001195 LabA_like proteins; Region: LabA_like; cd06167 522373001196 putative metal binding site [ion binding]; other site 522373001197 Uncharacterized conserved protein [Function unknown]; Region: COG1432 522373001198 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 522373001199 DNA binding site [nucleotide binding] 522373001200 active site 522373001201 Int/Topo IB signature motif; other site 522373001202 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 522373001203 HMMPfam hit to PF05973, Phage derived protein Gp49-like (DUF891), score 5.7e-22 522373001204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373001205 non-specific DNA binding site [nucleotide binding]; other site 522373001206 salt bridge; other site 522373001207 sequence-specific DNA binding site [nucleotide binding]; other site 522373001208 HMMPfam hit to PF01381, Helix-turn-helix, score 3.9e-06 522373001209 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 522373001210 1 probable transmembrane helix predicted for Smlt0339 by TMHMM2.0 at aa 5-27 522373001211 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373001212 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 522373001213 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373001214 HMMPfam hit to PF00023, Ankyrin repeat, score 0.012 522373001215 HMMPfam hit to PF00023, Ankyrin repeat, score 0.16 522373001216 HMMPfam hit to PF00023, Ankyrin repeat, score 5.2e-07 522373001217 HMMPfam hit to PF00023, Ankyrin repeat, score 28 522373001218 Arginase family; Region: Arginase; cd09989 522373001219 agmatinase; Region: agmatinase; TIGR01230 522373001220 active site 522373001221 Mn binding site [ion binding]; other site 522373001222 oligomer interface [polypeptide binding]; other site 522373001223 HMMPfam hit to PF00491, Arginase family, score 5.4e-98 522373001224 Predicted small secreted protein [Function unknown]; Region: COG5510 522373001225 HMMPfam hit to PF08085, Entericidin EcnA/B family, score 8.2e-17 522373001226 1 probable transmembrane helix predicted for Smlt0342 by TMHMM2.0 at aa 5-27 522373001227 CsbD-like; Region: CsbD; cl17424 522373001228 HMMPfam hit to PF05532, CsbD-like, score 3.8e-11 522373001229 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 522373001230 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 522373001231 active site 522373001232 HIGH motif; other site 522373001233 dimer interface [polypeptide binding]; other site 522373001234 KMSKS motif; other site 522373001235 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 522373001236 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 2.5e-61 522373001237 3 probable transmembrane helices predicted for Smlt0346 by TMHMM2.0 at aa 15-37, 49-71 and 81-103 522373001238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 522373001239 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 3.8e-22 522373001240 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 522373001241 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 522373001242 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 522373001243 PA/protease or protease-like domain interface [polypeptide binding]; other site 522373001244 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 522373001245 metal binding site [ion binding]; metal-binding site 522373001246 HMMPfam hit to PF04389, Peptidase family M28, score 3.7e-64 522373001247 3 probable transmembrane helices predicted for Smlt0349 by TMHMM2.0 at aa 10-27, 34-56 and 83-105 522373001248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373001249 metabolite-proton symporter; Region: 2A0106; TIGR00883 522373001250 putative substrate translocation pore; other site 522373001251 HMMPfam hit to PF00083, Sugar (and other) transporter score 2.9e-20 522373001252 12 probable transmembrane helices predicted for Smlt0350 by TMHMM2.0 at aa 27-49, 64-86, 93-115, 120-142, 162-184, 194-213, 250-272, 287-309, 318-335, 345-367, 379-401 and 411-433 522373001253 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.6e-14 522373001254 5 probable transmembrane helices predicted for Smlt0351 by TMHMM2.0 at aa 153-175, 205-227, 242-261, 274-296 and 322-344 522373001255 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 522373001256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373001257 Walker A/P-loop; other site 522373001258 ATP binding site [chemical binding]; other site 522373001259 Q-loop/lid; other site 522373001260 ABC transporter signature motif; other site 522373001261 Walker B; other site 522373001262 D-loop; other site 522373001263 H-loop/switch region; other site 522373001264 HMMPfam hit to PF00005, ABC transporter score 8.6e-52 522373001265 HEAT repeats; Region: HEAT_2; pfam13646 522373001266 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 522373001267 EamA-like transporter family; Region: EamA; pfam00892 522373001268 EamA-like transporter family; Region: EamA; pfam00892 522373001269 10 probable transmembrane helices predicted for Smlt0357 by TMHMM2.0 at aa 13-35, 50-69, 81-100, 104-126, 133-152, 156-178, 185-207, 222-244, 251-270 and 280-297 522373001270 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 8.9e-18 522373001271 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.8e-19 522373001272 Predicted permeases [General function prediction only]; Region: RarD; COG2962 522373001273 10 probable transmembrane helices predicted for Smlt0358 by TMHMM2.0 at aa 12-30, 40-62, 74-96, 101-123, 130-147, 152-169, 178-200, 215-237, 242-264 and 274-291 522373001274 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2e-07 522373001275 HMMPfam hit to PF04142, Nucleotide-sugar transporter score 0.0044 522373001276 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.9e-08 522373001277 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 522373001278 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373001279 N-terminal plug; other site 522373001280 ligand-binding site [chemical binding]; other site 522373001281 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373001282 HMMPfam hit to PF00593, TonB dependent receptor, score 1.7e-25 522373001283 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 6.9e-19 522373001284 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373001285 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 522373001286 FtsX-like permease family; Region: FtsX; pfam02687 522373001287 HMMPfam hit to PF02687, Predicted permease, score 1.2e-22 522373001288 6 probable transmembrane helices predicted for Smlt0360 by TMHMM2.0 at aa 9-27, 31-48, 69-91, 312-334, 363-385 and 405-427 522373001289 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373001290 FtsX-like permease family; Region: FtsX; pfam02687 522373001291 HMMPfam hit to PF02687, Predicted permease, score 3.7e-28 522373001292 4 probable transmembrane helices predicted for Smlt0361 by TMHMM2.0 at aa 20-42, 255-277, 312-334 and 349-371 522373001293 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 522373001294 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 522373001295 Walker A/P-loop; other site 522373001296 ATP binding site [chemical binding]; other site 522373001297 Q-loop/lid; other site 522373001298 ABC transporter signature motif; other site 522373001299 Walker B; other site 522373001300 D-loop; other site 522373001301 H-loop/switch region; other site 522373001302 HMMPfam hit to PF00005, ABC transporter score 5.1e-68 522373001303 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373001304 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373001305 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373001306 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.7e-05 522373001307 1 probable transmembrane helix predicted for Smlt0363 by TMHMM2.0 at aa 33-55 522373001308 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 522373001309 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 522373001310 Walker A/P-loop; other site 522373001311 ATP binding site [chemical binding]; other site 522373001312 Q-loop/lid; other site 522373001313 ABC transporter signature motif; other site 522373001314 Walker B; other site 522373001315 D-loop; other site 522373001316 H-loop/switch region; other site 522373001317 HMMPfam hit to PF00005, ABC transporter score 9.1e-48 522373001318 HMMPfam hit to PF01061, ABC-2 type transporter score 0.00027 522373001319 6 probable transmembrane helices predicted for Smlt0365 by TMHMM2.0 at aa 41-60, 70-92, 113-135, 148-170, 177-199 and 230-252 522373001320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 522373001321 Histidine kinase; Region: HisKA_3; pfam07730 522373001322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373001323 ATP binding site [chemical binding]; other site 522373001324 Mg2+ binding site [ion binding]; other site 522373001325 G-X-G motif; other site 522373001326 5 probable transmembrane helices predicted for Smlt0366 by TMHMM2.0 at aa 31-53, 55-77, 87-109, 121-143 and 148-165 522373001327 HMMPfam hit to PF07730, Histidine kinase, score 1.3e-24 522373001328 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.7e-17 522373001329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373001330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373001331 active site 522373001332 phosphorylation site [posttranslational modification] 522373001333 intermolecular recognition site; other site 522373001334 dimerization interface [polypeptide binding]; other site 522373001335 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373001336 DNA binding residues [nucleotide binding] 522373001337 dimerization interface [polypeptide binding]; other site 522373001338 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.6e-33 522373001339 HMMPfam hit to PF08281, Sigma-70, region, score 0.00081 522373001340 HMMPfam hit to PF04545, Sigma-70, region, score 1.5e-06 522373001341 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.4e-19 522373001342 HMMPfam hit to PF04967, HTH DNA binding domain, score 9.3e-05 522373001343 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373001344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373001345 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373001346 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373001347 HMMPfam hit to PF01548, Transposase, score 2.6e-10 522373001348 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 522373001349 HMMPfam hit to PF01292, Cytochrome b561 family, score 3.1e-33 522373001350 3 probable transmembrane helices predicted for Smlt0371 by TMHMM2.0 at aa 4-26, 77-99 and 129-151 522373001351 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 522373001352 putative heme binding pocket [chemical binding]; other site 522373001353 HMMPfam hit to PF00199, Catalase, score 5.9e-07 522373001354 1 probable transmembrane helix predicted for Smlt0372 by TMHMM2.0 at aa 39-61 522373001355 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 522373001356 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 522373001357 interface (dimer of trimers) [polypeptide binding]; other site 522373001358 Substrate-binding/catalytic site; other site 522373001359 Zn-binding sites [ion binding]; other site 522373001360 HMMPfam hit to PF00883, Cytosol aminopeptidase family, cataly, score 5.4e-100 522373001361 HMMPfam hit to PF02789, Cytosol aminopeptidase family, N-term, score 0.0001 522373001362 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 522373001363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373001364 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 8.3e-25 522373001365 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 522373001366 Domain of unknown function DUF20; Region: UPF0118; pfam01594 522373001367 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 5.7e-27 522373001368 6 probable transmembrane helices predicted for Smlt0377 by TMHMM2.0 at aa 50-72, 79-101, 171-188, 224-246, 261-283 and 323-345 522373001369 2 probable transmembrane helices predicted for Smlt0379 by TMHMM2.0 at aa 64-86 and 96-118 522373001370 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 522373001371 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 522373001372 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 522373001373 protein binding site [polypeptide binding]; other site 522373001374 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 522373001375 protein binding site [polypeptide binding]; other site 522373001376 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.4e-11 522373001377 HMMPfam hit to PF00089, Trypsin, score 4.2e-17 522373001378 HMMPfam hit to PF06392, no description, score 19 522373001379 HMMPfam hit to PF06392, no description, score 18 522373001380 1 probable transmembrane helix predicted for Smlt0384 by TMHMM2.0 at aa 20-42 522373001381 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 522373001382 HMMPfam hit to PF07237, Protein of unknown function (DUF1428), score 3.6e-78 522373001383 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 522373001384 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373001385 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 522373001386 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 4.9e-23 522373001387 HMMPfam hit to PF00930, Dipeptidyl peptidase IV (DPP IV) N-termi, score 7.9e-12 522373001388 sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273 522373001389 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373001390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373001391 active site 522373001392 dimerization interface [polypeptide binding]; other site 522373001393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373001394 DNA binding residues [nucleotide binding] 522373001395 dimerization interface [polypeptide binding]; other site 522373001396 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.2e-14 522373001397 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 6.9e-11 522373001398 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 522373001399 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 522373001400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373001401 11 probable transmembrane helices predicted for Smlt0392 by TMHMM2.0 at aa 29-46, 61-83, 95-117, 122-144, 151-170, 180-197, 233-255, 265-284, 297-319, 353-372 and 379-401 522373001402 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.9e-38 522373001403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373001404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373001405 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 522373001406 putative dimerization interface [polypeptide binding]; other site 522373001407 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.5e-21 522373001408 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.2e-47 522373001409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 522373001410 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 522373001411 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 522373001412 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 3e-34 522373001413 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 5.3e-25 522373001414 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 522373001415 malonic semialdehyde reductase; Provisional; Region: PRK10538 522373001416 putative NAD(P) binding site [chemical binding]; other site 522373001417 homotetramer interface [polypeptide binding]; other site 522373001418 homodimer interface [polypeptide binding]; other site 522373001419 active site 522373001420 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.6e-32 522373001421 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 9.6e-05 522373001422 Sporulation related domain; Region: SPOR; pfam05036 522373001423 HMMPfam hit to PF05036, Sporulation related domain, score 2.2e-17 522373001424 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 522373001425 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 522373001426 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 522373001427 active site 522373001428 HIGH motif; other site 522373001429 KMSK motif region; other site 522373001430 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 522373001431 tRNA binding surface [nucleotide binding]; other site 522373001432 anticodon binding site; other site 522373001433 HMMPfam hit to PF05746, DALR anticodon binding domain, score 1.9e-50 522373001434 HMMPfam hit to PF00750, tRNA synthetases class I (R), score 1.8e-66 522373001435 HMMPfam hit to PF03485, Arginyl tRNA synthetase N terminal do, score 1e-33 522373001436 hypothetical protein; Reviewed; Region: PRK00024 522373001437 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 522373001438 MPN+ (JAMM) motif; other site 522373001439 Zinc-binding site [ion binding]; other site 522373001440 HMMPfam hit to PF04002, RadC, DNA repair protein, score 4.3e-73 522373001441 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373001442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373001443 active site 522373001444 phosphorylation site [posttranslational modification] 522373001445 intermolecular recognition site; other site 522373001446 dimerization interface [polypeptide binding]; other site 522373001447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373001448 DNA binding residues [nucleotide binding] 522373001449 dimerization interface [polypeptide binding]; other site 522373001450 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 1.3e-18 522373001451 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.2e-21 522373001452 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 522373001453 Flavoprotein; Region: Flavoprotein; pfam02441 522373001454 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 522373001455 HMMPfam hit to PF02441, Flavoprotein, score 2.1e-40 522373001456 HMMPfam hit to PF04127, DNA / pantothenate metabolism flavoprote, score 1.8e-26 522373001457 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 522373001458 trimer interface [polypeptide binding]; other site 522373001459 active site 522373001460 HMMPfam hit to PF00692, dUTPase, score 6e-46 522373001461 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 522373001462 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 522373001463 active site 522373001464 substrate binding site [chemical binding]; other site 522373001465 metal binding site [ion binding]; metal-binding site 522373001466 2 probable transmembrane helices predicted for Smlt0403 by TMHMM2.0 at aa 5-24 and 227-249 522373001467 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 2.6e-47 522373001468 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 4.4e-45 522373001469 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 1.2e-42 522373001470 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 5.8e-17 522373001471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373001472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373001473 active site 522373001474 phosphorylation site [posttranslational modification] 522373001475 intermolecular recognition site; other site 522373001476 dimerization interface [polypeptide binding]; other site 522373001477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373001478 DNA binding site [nucleotide binding] 522373001479 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 8.1e-19 522373001480 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.8e-33 522373001481 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 522373001482 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 522373001483 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 522373001484 Ligand Binding Site [chemical binding]; other site 522373001485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373001486 dimer interface [polypeptide binding]; other site 522373001487 phosphorylation site [posttranslational modification] 522373001488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373001489 ATP binding site [chemical binding]; other site 522373001490 Mg2+ binding site [ion binding]; other site 522373001491 G-X-G motif; other site 522373001492 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.4e-31 522373001493 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.5e-17 522373001494 4 probable transmembrane helices predicted for Smlt0405 by TMHMM2.0 at aa 392-414, 417-436, 440-459 and 472-491 522373001495 HMMPfam hit to PF00582, Universal stress protein family, score 4.9e-14 522373001496 HMMPfam hit to PF02702, Osmosensitive K+ channel His kinase sensor, score 1.2e-152 522373001497 K+-transporting ATPase, c chain; Region: KdpC; cl00944 522373001498 HMMPfam hit to PF02669, K+-transporting ATPase, c chain, score 7.1e-58 522373001499 1 probable transmembrane helix predicted for Smlt0406 by TMHMM2.0 at aa 34-56 522373001500 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 522373001501 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 522373001502 Soluble P-type ATPase [General function prediction only]; Region: COG4087 522373001503 7 probable transmembrane helices predicted for Smlt0407 by TMHMM2.0 at aa 39-61, 65-87, 226-248, 258-280, 590-612, 622-644 and 657-679 522373001504 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 5.8e-32 522373001505 HMMPfam hit to PF00122, E1-E2 ATPase, score 3.4e-49 522373001506 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 522373001507 HMMPfam hit to PF03814, Potassium-transporting ATPase A subunit, score 2.1e-209 522373001508 10 probable transmembrane helices predicted for Smlt0408 by TMHMM2.0 at aa 4-23, 60-82, 133-155, 185-207, 266-288, 295-317, 382-404, 425-447, 491-513 and 534-556 522373001509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 522373001510 active site 522373001511 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.1e-33 522373001512 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 522373001513 putative active site [active] 522373001514 putative catalytic site [active] 522373001515 putative DNA binding site [nucleotide binding]; other site 522373001516 putative phosphate binding site [ion binding]; other site 522373001517 metal binding site A [ion binding]; metal-binding site 522373001518 putative AP binding site [nucleotide binding]; other site 522373001519 putative metal binding site B [ion binding]; other site 522373001520 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 2.8e-51 522373001521 muropeptide transporter; Validated; Region: ampG; cl17669 522373001522 muropeptide transporter; Reviewed; Region: ampG; PRK11902 522373001523 12 probable transmembrane helices predicted for Smlt0413 by TMHMM2.0 at aa 23-45, 55-77, 94-113, 123-145, 174-196, 200-217, 257-279, 294-316, 321-343, 353-375, 388-410 and 425-447 522373001524 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.2e-06 522373001525 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 522373001526 HMMPfam hit to PF03702, Uncharacterised protein family (UPF0075), score 1e-190 522373001527 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 522373001528 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 522373001529 Peptidase family M23; Region: Peptidase_M23; pfam01551 522373001530 HMMPfam hit to PF01551, Peptidase family M23, score 2.8e-51 522373001531 HMMPfam hit to PF04225, Opacity-associated protein A LysM-like, score 0.0032 522373001532 1 probable transmembrane helix predicted for Smlt0416 by TMHMM2.0 at aa 49-71 522373001533 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 522373001534 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 522373001535 active site 522373001536 HIGH motif; other site 522373001537 dimer interface [polypeptide binding]; other site 522373001538 KMSKS motif; other site 522373001539 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373001540 RNA binding surface [nucleotide binding]; other site 522373001541 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 4.2e-100 522373001542 HMMPfam hit to PF01479, S4 domain, score 0.013 522373001543 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 522373001544 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 522373001545 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 522373001546 PA/protease or protease-like domain interface [polypeptide binding]; other site 522373001547 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 522373001548 metal binding site [ion binding]; metal-binding site 522373001549 HMMPfam hit to PF04389, Peptidase family M28, score 3.6e-63 522373001550 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 522373001551 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 522373001552 Peptidase family M23; Region: Peptidase_M23; pfam01551 522373001553 HMMPfam hit to PF01551, Peptidase family M23, score 9.2e-40 522373001554 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 522373001555 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 522373001556 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 522373001557 protein binding site [polypeptide binding]; other site 522373001558 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 522373001559 Catalytic dyad [active] 522373001560 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 3.9e-07 522373001561 HMMPfam hit to PF03572, Peptidase family S41, score 2e-75 522373001562 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 522373001563 HMMPfam hit to PF01694, Rhomboid family, score 6.3e-39 522373001564 6 probable transmembrane helices predicted for Smlt0422 by TMHMM2.0 at aa 12-34, 81-98, 105-127, 132-154, 166-188 and 198-220 522373001565 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 522373001566 1 probable transmembrane helix predicted for Smlt0423 by TMHMM2.0 at aa 7-29 522373001567 HMMPfam hit to PF03349, Outer membrane protein transport protein (O, score 2.5e-132 522373001568 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 522373001569 HMMPfam hit to PF04973, Nicotinamide mononucleotide transport, score 1.1e-11 522373001570 5 probable transmembrane helices predicted for Smlt0424 by TMHMM2.0 at aa 38-55, 60-82, 97-116, 123-145 and 165-187 522373001571 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 522373001572 active site 522373001573 nucleotide binding site [chemical binding]; other site 522373001574 HIGH motif; other site 522373001575 KMSKS motif; other site 522373001576 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 522373001577 AAA domain; Region: AAA_28; pfam13521 522373001578 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 522373001579 Proline dehydrogenase; Region: Pro_dh; pfam01619 522373001580 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 522373001581 Glutamate binding site [chemical binding]; other site 522373001582 NAD binding site [chemical binding]; other site 522373001583 catalytic residues [active] 522373001584 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 8.3e-127 522373001585 HMMPfam hit to PF01619, Proline dehydrogenase, score 1.2e-131 522373001586 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 522373001587 2 probable transmembrane helices predicted for Smlt0427 by TMHMM2.0 at aa 61-83 and 87-106 522373001588 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 522373001589 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 522373001590 3 probable transmembrane helices predicted for Smlt0428 by TMHMM2.0 at aa 12-34, 59-81 and 102-124 522373001591 HMMPfam hit to PF02790, Cytochrome C oxidase subunit II, transmembra, score 1.2e-06 522373001592 HMMPfam hit to PF00116, Cytochrome C oxidase subunit II, periplasmic, score 3.8e-44 522373001593 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 522373001594 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 522373001595 Subunit I/III interface [polypeptide binding]; other site 522373001596 D-pathway; other site 522373001597 Subunit I/VIIc interface [polypeptide binding]; other site 522373001598 Subunit I/IV interface [polypeptide binding]; other site 522373001599 Subunit I/II interface [polypeptide binding]; other site 522373001600 Low-spin heme (heme a) binding site [chemical binding]; other site 522373001601 Subunit I/VIIa interface [polypeptide binding]; other site 522373001602 Subunit I/VIa interface [polypeptide binding]; other site 522373001603 Dimer interface; other site 522373001604 Putative water exit pathway; other site 522373001605 Binuclear center (heme a3/CuB) [ion binding]; other site 522373001606 K-pathway; other site 522373001607 Subunit I/Vb interface [polypeptide binding]; other site 522373001608 Putative proton exit pathway; other site 522373001609 Subunit I/VIb interface; other site 522373001610 Subunit I/VIc interface [polypeptide binding]; other site 522373001611 Electron transfer pathway; other site 522373001612 Subunit I/VIIIb interface [polypeptide binding]; other site 522373001613 Subunit I/VIIb interface [polypeptide binding]; other site 522373001614 HMMPfam hit to PF00115, Cytochrome C and Quinol oxidase polypeptide, score 7.7e-256 522373001615 12 probable transmembrane helices predicted for Smlt0429 by TMHMM2.0 at aa 40-62, 82-104, 124-146, 166-188, 209-231, 258-280, 287-309, 324-346, 359-381, 396-418, 435-457 and 472-494 522373001616 1 probable transmembrane helix predicted for Smlt0430 by TMHMM2.0 at aa 59-81 522373001617 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 522373001618 1 probable transmembrane helix predicted for Smlt0431 by TMHMM2.0 at aa 13-35 522373001619 HMMPfam hit to PF04442, Cytochrome c oxidase assembly protein Cta, score 1.5e-49 522373001620 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 522373001621 Subunit III/VIIa interface [polypeptide binding]; other site 522373001622 Phospholipid binding site [chemical binding]; other site 522373001623 Subunit I/III interface [polypeptide binding]; other site 522373001624 Subunit III/VIb interface [polypeptide binding]; other site 522373001625 Subunit III/VIa interface; other site 522373001626 Subunit III/Vb interface [polypeptide binding]; other site 522373001627 HMMPfam hit to PF00510, Cytochrome c oxidase subunit III, score 1.8e-64 522373001628 7 probable transmembrane helices predicted for Smlt0432 by TMHMM2.0 at aa 21-38, 42-64, 85-107, 152-174, 187-209, 229-251 and 271-290 522373001629 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 522373001630 2 probable transmembrane helices predicted for Smlt0433 by TMHMM2.0 at aa 32-54 and 70-89 522373001631 SURF1 family; Region: SURF1; pfam02104 522373001632 2 probable transmembrane helices predicted for Smlt0434 by TMHMM2.0 at aa 7-29 and 208-230 522373001633 1 probable transmembrane helix predicted for Smlt0435 by TMHMM2.0 at aa 20-42 522373001634 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 522373001635 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 522373001636 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 522373001637 HMMPfam hit to PF02628, Cytochrome oxidase assembly protein, score 1.3e-05 522373001638 10 probable transmembrane helices predicted for Smlt0436 by TMHMM2.0 at aa 12-34, 82-101, 108-130, 134-156, 163-182, 186-208, 229-251, 304-326, 333-351 and 361-383 522373001639 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 522373001640 UbiA prenyltransferase family; Region: UbiA; pfam01040 522373001641 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 522373001642 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 522373001643 10 probable transmembrane helices predicted for Smlt0439 by TMHMM2.0 at aa 13-35, 40-57, 70-89, 99-121, 133-155, 165-185, 198-217, 232-254, 266-288 and 293-315 522373001644 HMMPfam hit to PF01758, Sodium Bile acid symporter family, score 0.00046 522373001645 Putative phosphatase (DUF442); Region: DUF442; cl17385 522373001646 HMMPfam hit to PF04273, Protein of unknown function (DUF442), score 6.1e-07 522373001647 DNA primase; Validated; Region: dnaG; PRK05667 522373001648 CHC2 zinc finger; Region: zf-CHC2; pfam01807 522373001649 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 522373001650 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 522373001651 active site 522373001652 metal binding site [ion binding]; metal-binding site 522373001653 interdomain interaction site; other site 522373001654 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 522373001655 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 522373001656 HMMPfam hit to PF08278, DNA primase DnaG DnaB-binding, score 7.5e-41 522373001657 HMMPfam hit to PF01751, Toprim domain, score 1.4e-24 522373001658 HMMPfam hit to PF08275, DNA primase catalytic core, N-terminal, score 2.1e-62 522373001659 HMMPfam hit to PF01807, CHC2 zinc finger, score 2.7e-59 522373001660 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 522373001661 HMMPfam hit to PF03631, Ribonuclease BN-like family, score 5.4e-68 522373001662 6 probable transmembrane helices predicted for Smlt0442 by TMHMM2.0 at aa 40-62, 103-125, 152-174, 184-206, 219-241 and 256-278 522373001663 Yqey-like protein; Region: YqeY; pfam09424 522373001664 HMMPfam hit to PF02637, GatB/Yqey domain, score 1.4e-49 522373001665 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 522373001666 HMMPfam hit to PF01165, Ribosomal protein S21, score 4.4e-31 522373001667 UGMP family protein; Validated; Region: PRK09604 522373001668 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 522373001669 HMMPfam hit to PF00814, Glycoprotease family, score 5.1e-75 522373001670 Abi-like protein; Region: Abi_2; pfam07751 522373001671 HMMPfam hit to PF07512, Protein of unknown function (DUF1526), score 9.7e-44 522373001672 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 522373001673 homooctamer interface [polypeptide binding]; other site 522373001674 active site 522373001675 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 3.1e-40 522373001676 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 522373001677 Mechanosensitive ion channel; Region: MS_channel; pfam00924 522373001678 3 probable transmembrane helices predicted for Smlt0448 by TMHMM2.0 at aa 75-97, 118-140 and 150-172 522373001679 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 8.1e-36 522373001680 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 522373001681 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 522373001682 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 522373001683 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N termina, score 1.5e-82 522373001684 HMMPfam hit to PF01915, Glycosyl hydrolase family 3 C termina, score 9.6e-82 522373001685 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 522373001686 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 522373001687 HMMPfam hit to PF07995, Glucose / Sorbosone dehydrogenase, score 1.1e-60 522373001688 Predicted membrane protein [Function unknown]; Region: COG4682 522373001689 yiaA/B two helix domain; Region: YiaAB; pfam05360 522373001690 4 probable transmembrane helices predicted for Smlt0452 by TMHMM2.0 at aa 12-34, 44-61, 74-96 and 106-123 522373001691 HMMPfam hit to PF05360, yiaA/B two helix domain, score 1.7e-19 522373001692 HMMPfam hit to PF05360, yiaA/B two helix domain, score 4.3e-20 522373001693 amino acid transporter; Region: 2A0306; TIGR00909 522373001694 HMMPfam hit to PF00324, Amino acid permease, score 1.1e-11 522373001695 12 probable transmembrane helices predicted for Smlt0454 by TMHMM2.0 at aa 29-51, 56-75, 95-117, 137-159, 166-188, 208-227, 240-262, 277-299, 337-359, 363-382, 394-416 and 420-437 522373001696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 522373001697 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 522373001698 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 522373001699 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 522373001700 putative active site [active] 522373001701 HMMPfam hit to PF01380, SIS domain, score 4e-12 522373001702 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 3.5e-22 522373001703 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 522373001704 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 522373001705 active site 522373001706 HMMPfam hit to PF01188, Mandelate racemase / muconate lactonizing en, score 5.9e-30 522373001707 HMMPfam hit to PF02746, Mandelate racemase / muconate lactonizing en, score 7.1e-22 522373001708 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 522373001709 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 522373001710 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 522373001711 NlpC/P60 family; Region: NLPC_P60; cl17555 522373001712 HMMPfam hit to PF00877, NlpC/P60 family, score 2.7e-11 522373001713 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 522373001714 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 522373001715 HMMPfam hit to PF01841, Transglutaminase-like superfamily, score 1.1e-06 522373001716 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 522373001717 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373001718 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373001719 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373001720 1 probable transmembrane helix predicted for Smlt0461 by TMHMM2.0 at aa 9-28 522373001721 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 6.4e-12 522373001722 HMMPfam hit to PF00593, TonB dependent receptor, score 1.8e-08 522373001723 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373001724 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373001725 HMMPfam hit to PF00144, Beta-lactamase, score 6.6e-66 522373001726 HMMPfam hit to PF01427, D-ala-D-ala dipeptidase, score 1.3e-41 522373001727 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 522373001728 HMMPfam hit to PF02557, D-alanyl-D-alanine carboxypeptidase, score 0.0015 522373001729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373001730 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373001731 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373001732 HMMPfam hit to PF01548, Transposase, score 2.6e-10 522373001733 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 2e-24 522373001734 3 probable transmembrane helices predicted for Smlt0466 by TMHMM2.0 at aa 7-29, 44-66 and 91-113 522373001735 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 522373001736 EF-hand domain pair; Region: EF_hand_5; pfam13499 522373001737 Ca2+ binding site [ion binding]; other site 522373001738 HMMPfam hit to PF00036, EF hand, score 8.1e-05 522373001739 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 522373001740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 522373001741 motif II; other site 522373001742 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.9e-07 522373001743 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 522373001744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 522373001745 HMMPfam hit to PF07063, Protein of unknown function (DUF1338), score 2.7e-61 522373001746 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 522373001747 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 522373001748 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 522373001749 HMMPfam hit to PF02550, Acetyl-CoA hydrolase/transferase, score 7.7e-155 522373001750 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 522373001751 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 522373001752 metal binding triad; other site 522373001753 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 522373001754 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 522373001755 metal binding triad; other site 522373001756 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 8.8e-80 522373001757 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 5.5e-74 522373001758 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 522373001759 4 probable transmembrane helices predicted for Smlt0476 by TMHMM2.0 at aa 17-39, 43-60, 72-94 and 158-177 522373001760 HMMPfam hit to PF02592, Uncharacterized ACR, YhhQ family COG1738, score 5.4e-17 522373001761 2 probable transmembrane helices predicted for Smlt0477 by TMHMM2.0 at aa 5-27 and 37-59 522373001762 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 522373001763 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 522373001764 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 522373001765 HMMPfam hit to PF06258, Protein of unknown function (DUF1022), score 1.8e-121 522373001766 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 522373001767 putative FMN binding site [chemical binding]; other site 522373001768 HMMPfam hit to PF00881, Nitroreductase family, score 4.1e-12 522373001769 Uncharacterized conserved protein [Function unknown]; Region: COG2353 522373001770 HMMPfam hit to PF04264, YceI like family, score 8.5e-75 522373001771 3 probable transmembrane helices predicted for Smlt0485 by TMHMM2.0 at aa 15-37, 58-80 and 226-248 522373001772 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 522373001773 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 522373001774 FAD binding pocket [chemical binding]; other site 522373001775 FAD binding motif [chemical binding]; other site 522373001776 phosphate binding motif [ion binding]; other site 522373001777 NAD binding pocket [chemical binding]; other site 522373001778 HMMPfam hit to PF04954, Siderophore-interacting protein, score 1.1e-50 522373001779 HMMPfam hit to PF08021, Siderophore-interacting FAD-binding dom, score 1.9e-51 522373001780 Predicted transcriptional regulators [Transcription]; Region: COG1695 522373001781 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 522373001782 HMMPfam hit to PF03551, Transcriptional regulator PadR-like family, score 1.5e-23 522373001783 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 522373001784 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 522373001785 dimer interface [polypeptide binding]; other site 522373001786 TPP-binding site [chemical binding]; other site 522373001787 putative helicase, pseudogene;This CDS has been interrupted by the insertion of a mobile element; similarity:fasta; with=UniProt:Q2ZSP4; Shewanella putrefaciens CN-32.; Helicase, C-terminal:Type III restriction enzyme, res subunit:DEAD/DEAH box helicase, N-terminal.; length=1020; id 38.596%; ungapped id 39.839%; E()=1.5e-90; 1026 aa overlap; query 13-1031; subject 15-1015 522373001788 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 3e-08 522373001789 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 0.011 522373001790 putative transposase OrfB; Reviewed; Region: PHA02517 522373001791 HTH-like domain; Region: HTH_21; pfam13276 522373001792 Integrase core domain; Region: rve; pfam00665 522373001793 Integrase core domain; Region: rve_2; pfam13333 522373001794 HMMPfam hit to PF00665, Integrase core domain, score 9e-51 522373001795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373001796 Transposase; Region: HTH_Tnp_1; pfam01527 522373001797 HMMPfam hit to PF01527, Transposase, score 1.1e-21 522373001798 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 522373001799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 522373001800 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 9.1e-06 522373001801 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 522373001802 Uncharacterized conserved protein [Function unknown]; Region: COG3391 522373001803 SnoaL-like domain; Region: SnoaL_3; pfam13474 522373001804 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 522373001805 TAP-like protein; Region: Abhydrolase_4; pfam08386 522373001806 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 5.5e-33 522373001807 2 probable transmembrane helices predicted for Smlt0509 by TMHMM2.0 at aa 15-37 and 92-111 522373001808 4 probable transmembrane helices predicted for Smlt0510 by TMHMM2.0 at aa 63-85, 128-147, 159-181 and 233-255 522373001809 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 522373001810 NodB motif; other site 522373001811 putative active site [active] 522373001812 putative catalytic site [active] 522373001813 putative Zn binding site [ion binding]; other site 522373001814 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 6.3e-07 522373001815 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 522373001816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373001817 S-adenosylmethionine binding site [chemical binding]; other site 522373001818 3 probable transmembrane helices predicted for Smlt0516 by TMHMM2.0 at aa 12-34, 39-61 and 68-90 522373001819 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 522373001820 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 522373001821 HMMPfam hit to PF01545, Cation efflux family, score 3.6e-51 522373001822 6 probable transmembrane helices predicted for Smlt0517 by TMHMM2.0 at aa 30-47, 57-74, 95-117, 132-149, 189-211 and 216-238 522373001823 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 522373001824 Winged helix-turn helix; Region: HTH_29; pfam13551 522373001825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 522373001826 Integrase core domain; Region: rve; pfam00665 522373001827 Integrase core domain; Region: rve_3; pfam13683 522373001828 HMMPfam hit to PF00665, Integrase core domain, score 4.9e-39 522373001829 MerC mercury resistance protein; Region: MerC; pfam03203 522373001830 3 probable transmembrane helices predicted for Smlt0519 by TMHMM2.0 at aa 13-35, 45-64 and 71-93 522373001831 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 522373001832 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 522373001833 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 522373001834 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 522373001835 HMMPfam hit to PF02492, CobW/HypB/UreG, nucleotide-binding domain, score 1.1e-83 522373001836 HMMPfam hit to PF07683, Cobalamin synthesis protein cobW C-terminal, score 1.5e-32 522373001837 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 522373001838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373001839 Walker A/P-loop; other site 522373001840 ATP binding site [chemical binding]; other site 522373001841 Q-loop/lid; other site 522373001842 ABC transporter signature motif; other site 522373001843 Walker B; other site 522373001844 D-loop; other site 522373001845 H-loop/switch region; other site 522373001846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 522373001847 HMMPfam hit to PF00005, ABC transporter score 1.9e-29 522373001848 HMMPfam hit to PF00005, ABC transporter score 2.3e-31 522373001849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373001850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373001851 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 522373001852 putative effector binding pocket; other site 522373001853 putative dimerization interface [polypeptide binding]; other site 522373001854 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-45 522373001855 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.8e-14 522373001856 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373001857 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373001858 HMMPfam hit to PF00144, Beta-lactamase, score 2.4e-67 522373001859 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 522373001860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373001861 putative substrate translocation pore; other site 522373001862 12 probable transmembrane helices predicted for Smlt0524 by TMHMM2.0 at aa 20-42, 57-79, 88-107, 112-134, 147-169, 174-196, 217-236, 256-275, 282-301, 306-325, 345-367 and 371-388 522373001863 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-41 522373001864 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 522373001865 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 522373001866 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373001867 HMMPfam hit to PF00563, EAL domain, score 6.8e-89 522373001868 2 probable transmembrane helices predicted for Smlt0525 by TMHMM2.0 at aa 6-28 and 237-259 522373001869 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 522373001870 HMMPfam hit to PF00324, Amino acid permease, score 1.3e-137 522373001871 12 probable transmembrane helices predicted for Smlt0526 by TMHMM2.0 at aa 63-80, 84-106, 143-165, 170-192, 199-221, 241-263, 286-308, 318-340, 378-400, 410-432, 445-467 and 477-494 522373001872 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 522373001873 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 522373001874 N-acetyl-D-glucosamine binding site [chemical binding]; other site 522373001875 catalytic residue [active] 522373001876 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 8.7e-30 522373001877 NHL repeat; Region: NHL; pfam01436 522373001878 NHL repeat; Region: NHL; pfam01436 522373001879 HMMPfam hit to PF01436, NHL repeat, score 8.5 522373001880 HMMPfam hit to PF01436, NHL repeat, score 9.3e-09 522373001881 HMMPfam hit to PF01436, NHL repeat, score 7.7e-07 522373001882 HMMPfam hit to PF01436, NHL repeat, score 0.017 522373001883 HMMPfam hit to PF01436, NHL repeat, score 0.93 522373001884 HMMPfam hit to PF01436, NHL repeat, score 0.00016 522373001885 HMMPfam hit to PF01551, Peptidase family M23, score 0.0029 522373001886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 522373001887 HMMPfam hit to PF04946, DGPF domain, score 4.8e-40 522373001888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 522373001889 HMMPfam hit to PF04946, DGPF domain, score 3.3e-36 522373001890 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 522373001891 dimer interface [polypeptide binding]; other site 522373001892 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373001893 HMMPfam hit to PF06983, 3-demethylubiquinone-9 3-methyltransfera, score 1.1e-05 522373001894 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/, score 0.0011 522373001895 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 522373001896 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 522373001897 HMMPfam hit to PF07237, Protein of unknown function (DUF1428), score 5.1e-55 522373001898 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 522373001899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373001900 HMMPfam hit to PF04542, Sigma-70 region, score 2.2e-15 522373001901 HMMPfam hit to PF08281, Sigma-70, region, score 3.8e-09 522373001902 1 probable transmembrane helix predicted for Smlt0538 by TMHMM2.0 at aa 32-51 522373001903 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 522373001904 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 522373001905 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 522373001906 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 522373001907 PA/protease or protease-like domain interface [polypeptide binding]; other site 522373001908 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 522373001909 metal binding site [ion binding]; metal-binding site 522373001910 HMMPfam hit to PF04389, Peptidase family M28, score 1e-66 522373001911 2 probable transmembrane helices predicted for Smlt0542 by TMHMM2.0 at aa 59-81 and 86-108 522373001912 Histidine kinase; Region: His_kinase; pfam06580 522373001913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373001914 Mg2+ binding site [ion binding]; other site 522373001915 HMMPfam hit to PF06580, Histidine kinase, score 1.8e-31 522373001916 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP9, score 4.8e-12 522373001917 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 522373001918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373001919 active site 522373001920 phosphorylation site [posttranslational modification] 522373001921 intermolecular recognition site; other site 522373001922 dimerization interface [polypeptide binding]; other site 522373001923 LytTr DNA-binding domain; Region: LytTR; smart00850 522373001924 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.4e-19 522373001925 HMMPfam hit to PF04397, LytTr DNA-binding domain, score 2.3e-22 522373001926 2 probable transmembrane helices predicted for Smlt0545 by TMHMM2.0 at aa 119-141 and 151-173 522373001927 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 522373001928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373001929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373001930 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 5.7e-21 522373001931 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373001932 11 probable transmembrane helices predicted for Smlt0548 by TMHMM2.0 at aa 15-37, 44-63, 78-100, 105-124, 167-189, 218-240, 250-272, 279-298, 303-325, 338-360 and 364-386 522373001933 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.7e-23 522373001934 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 522373001935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373001936 putative substrate translocation pore; other site 522373001937 12 probable transmembrane helices predicted for Smlt0549 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 99-121, 133-155, 165-187, 208-230, 240-262, 269-291, 295-317, 324-346 and 356-375 522373001938 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.1e-46 522373001939 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 522373001940 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 522373001941 active site 522373001942 Zn binding site [ion binding]; other site 522373001943 HMMPfam hit to PF01431, Peptidase family M13, score 1.1e-69 522373001944 HMMPfam hit to PF05649, Peptidase family M13, score 1.1e-154 522373001945 PAS fold; Region: PAS_3; pfam08447 522373001946 PAS domain S-box; Region: sensory_box; TIGR00229 522373001947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373001948 putative active site [active] 522373001949 heme pocket [chemical binding]; other site 522373001950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373001951 metal binding site [ion binding]; metal-binding site 522373001952 active site 522373001953 I-site; other site 522373001954 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373001955 2 probable transmembrane helices predicted for Smlt0551 by TMHMM2.0 at aa 84-106 and 347-369 522373001956 HMMPfam hit to PF00989, PAS fold, score 0.12 522373001957 HMMPfam hit to PF08447, PAS fold, score 1.9e-15 522373001958 HMMPfam hit to PF00989, PAS fold, score 1e-05 522373001959 HMMPfam hit to PF08448, PAS fold, score 4.4e-05 522373001960 HMMPfam hit to PF08447, PAS fold, score 0.0006 522373001961 HMMPfam hit to PF00990, GGDEF domain, score 1.6e-06 522373001962 HMMPfam hit to PF00563, EAL domain, score 2.6e-103 522373001963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373001964 LysR family transcriptional regulator; Provisional; Region: PRK14997 522373001965 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373001966 putative effector binding pocket; other site 522373001967 dimerization interface [polypeptide binding]; other site 522373001968 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.4e-56 522373001969 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 0.00016 522373001970 DoxX; Region: DoxX; cl17842 522373001971 HMMPfam hit to PF07681, DoxX, score 1.1e-31 522373001972 4 probable transmembrane helices predicted for Smlt0553 by TMHMM2.0 at aa 21-43, 53-75, 82-104 and 114-133 522373001973 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 522373001974 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 522373001975 putative active site [active] 522373001976 metal binding site [ion binding]; metal-binding site 522373001977 HMMPfam hit to PF02900, Catalytic LigB subunit of aromatic ring-open, score 1.4e-89 522373001978 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 522373001979 13 probable transmembrane helices predicted for Smlt0555 by TMHMM2.0 at aa 25-44, 46-68, 78-95, 108-130, 135-157, 182-201, 205-227, 239-256, 260-282, 295-317, 337-359, 380-402 and 417-439 522373001980 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 1.2e-54 522373001981 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 522373001982 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 522373001983 Winged helix-turn helix; Region: HTH_29; pfam13551 522373001984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 522373001985 Integrase core domain; Region: rve; pfam00665 522373001986 Integrase core domain; Region: rve_3; pfam13683 522373001987 HMMPfam hit to PF00665, Integrase core domain, score 4.9e-39 522373001988 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 522373001989 flagellar motor protein MotB; Validated; Region: motB; PRK09041 522373001990 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 522373001991 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 522373001992 ligand binding site [chemical binding]; other site 522373001993 HMMPfam hit to PF00691, OmpA family, score 1.7e-25 522373001994 1 probable transmembrane helix predicted for Smlt0561 by TMHMM2.0 at aa 28-47 522373001995 flagellar motor protein MotA; Validated; Region: PRK09110 522373001996 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 522373001997 4 probable transmembrane helices predicted for Smlt0562 by TMHMM2.0 at aa 5-27, 31-53, 175-197 and 202-224 522373001998 methionine sulfoxide reductase B; Provisional; Region: PRK00222 522373001999 SelR domain; Region: SelR; pfam01641 522373002000 HMMPfam hit to PF01641, SelR domain, score 1.3e-61 522373002001 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 522373002002 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373002003 putative DNA binding site [nucleotide binding]; other site 522373002004 putative Zn2+ binding site [ion binding]; other site 522373002005 AsnC family; Region: AsnC_trans_reg; pfam01037 522373002006 HMMPfam hit to PF01037, AsnC family, score 2.4e-27 522373002007 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 522373002008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 522373002009 hydroxyglutarate oxidase; Provisional; Region: PRK11728 522373002010 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.2e-107 522373002011 alanine racemase; Reviewed; Region: alr; PRK00053 522373002012 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 522373002013 active site 522373002014 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 522373002015 substrate binding site [chemical binding]; other site 522373002016 catalytic residues [active] 522373002017 dimer interface [polypeptide binding]; other site 522373002018 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 1.3e-90 522373002019 HMMPfam hit to PF00842, Alanine racemase, C-terminal domain, score 1.5e-57 522373002020 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 522373002021 1 probable transmembrane helix predicted for Smlt0569 by TMHMM2.0 at aa 28-47 522373002022 PAS domain; Region: PAS_9; pfam13426 522373002023 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 522373002024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373002025 putative active site [active] 522373002026 heme pocket [chemical binding]; other site 522373002027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373002028 dimer interface [polypeptide binding]; other site 522373002029 phosphorylation site [posttranslational modification] 522373002030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373002031 ATP binding site [chemical binding]; other site 522373002032 Mg2+ binding site [ion binding]; other site 522373002033 G-X-G motif; other site 522373002034 Response regulator receiver domain; Region: Response_reg; pfam00072 522373002035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373002036 active site 522373002037 phosphorylation site [posttranslational modification] 522373002038 intermolecular recognition site; other site 522373002039 dimerization interface [polypeptide binding]; other site 522373002040 HMMPfam hit to PF00989, PAS fold, score 3.8e-07 522373002041 HMMPfam hit to PF08448, PAS fold, score 1.2e-08 522373002042 HMMPfam hit to PF08447, PAS fold, score 5.4e-15 522373002043 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.1e-15 522373002044 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1e-25 522373002045 HMMPfam hit to PF00072, Response regulator receiver domain, score 3e-27 522373002046 Protein of unknown function (DUF3247); Region: DUF3247; pfam11607 522373002047 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 522373002048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373002049 HMMPfam hit to PF05175, Methyltransferase small domain, score 1.9e-73 522373002050 HMMPfam hit to PF08242, Methyltransferase domain, score 3.1e-06 522373002051 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 522373002052 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 522373002053 active site 522373002054 uracil binding [chemical binding]; other site 522373002055 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 6.9e-10 522373002056 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 522373002057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373002058 motif II; other site 522373002059 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.7e-26 522373002060 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 522373002061 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 522373002062 dimer interface [polypeptide binding]; other site 522373002063 active site 522373002064 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 1.7e-54 522373002065 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 4e-57 522373002066 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 522373002067 dimer interface [polypeptide binding]; other site 522373002068 active site 1 [active] 522373002069 active site 2 [active] 522373002070 HMMPfam hit to PF07977, FabA-like domain, score 1.4e-73 522373002071 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 522373002072 active site 522373002073 DNA polymerase IV; Validated; Region: PRK02406 522373002074 DNA binding site [nucleotide binding] 522373002075 HMMPfam hit to PF00817, impB/mucB/samB family, score 1e-104 522373002076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 522373002077 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 2.5e-19 522373002078 1 probable transmembrane helix predicted for Smlt0580 by TMHMM2.0 at aa 31-53 522373002079 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 522373002080 NADH(P)-binding; Region: NAD_binding_10; pfam13460 522373002081 NAD binding site [chemical binding]; other site 522373002082 substrate binding site [chemical binding]; other site 522373002083 putative active site [active] 522373002084 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.00022 522373002085 HMMPfam hit to PF05368, NmrA-like family, score 0.0045 522373002086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373002087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373002088 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373002089 putative effector binding pocket; other site 522373002090 dimerization interface [polypeptide binding]; other site 522373002091 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.9e-17 522373002092 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.6e-49 522373002093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373002094 S-adenosylmethionine binding site [chemical binding]; other site 522373002095 HMMPfam hit to PF08241, Methyltransferase domain, score 1.5e-20 522373002096 HMMPfam hit to PF08242, Methyltransferase domain, score 6.1e-07 522373002097 phosphoglycolate phosphatase; Provisional; Region: PRK13222 522373002098 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 522373002099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373002100 motif II; other site 522373002101 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3.2e-42 522373002102 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 522373002103 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373002104 N-terminal plug; other site 522373002105 ligand-binding site [chemical binding]; other site 522373002106 HMMPfam hit to PF00593, TonB dependent receptor, score 1.6e-29 522373002107 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.6e-26 522373002108 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 522373002109 catalytic core [active] 522373002110 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 2.8e-20 522373002111 TfoX C-terminal domain; Region: TfoX_C; pfam04994 522373002112 HMMPfam hit to PF04994, TfoX C-terminal domain, score 5.1e-15 522373002113 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 522373002114 GAF domain; Region: GAF_2; pfam13185 522373002115 HMMPfam hit to PF01590, GAF domain, score 1e-05 522373002116 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 522373002117 AAA domain; Region: AAA_26; pfam13500 522373002118 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 522373002119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373002120 DNA-binding site [nucleotide binding]; DNA binding site 522373002121 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373002122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373002123 homodimer interface [polypeptide binding]; other site 522373002124 catalytic residue [active] 522373002125 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.3e-08 522373002126 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.0047 522373002127 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR f, score 7.9e-10 522373002128 methionine sulfoxide reductase A; Provisional; Region: PRK13014 522373002129 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 7.7e-64 522373002130 1 probable transmembrane helix predicted for Smlt0591 by TMHMM2.0 at aa 15-34 522373002131 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 522373002132 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 522373002133 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 522373002134 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373002135 catalytic residues [active] 522373002136 HMMPfam hit to PF08534, Redoxin, score 3.5e-05 522373002137 6 probable transmembrane helices predicted for Smlt0592 by TMHMM2.0 at aa 5-27, 40-59, 69-91, 126-148, 158-180 and 201-223 522373002138 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmembran, score 1.1e-05 522373002139 methionine sulfoxide reductase B; Provisional; Region: PRK00222 522373002140 SelR domain; Region: SelR; pfam01641 522373002141 HMMPfam hit to PF01641, SelR domain, score 4.3e-69 522373002142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373002143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373002144 active site 522373002145 phosphorylation site [posttranslational modification] 522373002146 intermolecular recognition site; other site 522373002147 dimerization interface [polypeptide binding]; other site 522373002148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373002149 DNA binding site [nucleotide binding] 522373002150 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.4e-35 522373002151 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 3.3e-25 522373002152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373002153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373002154 dimer interface [polypeptide binding]; other site 522373002155 phosphorylation site [posttranslational modification] 522373002156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373002157 ATP binding site [chemical binding]; other site 522373002158 Mg2+ binding site [ion binding]; other site 522373002159 G-X-G motif; other site 522373002160 2 probable transmembrane helices predicted for Smlt0595 by TMHMM2.0 at aa 10-28 and 180-202 522373002161 HMMPfam hit to PF00672, HAMP domain, score 2.6e-07 522373002162 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 4.6e-18 522373002163 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.8e-27 522373002164 sensor protein RstB; Provisional; Region: PRK10604 522373002165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 522373002166 dimerization interface [polypeptide binding]; other site 522373002167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373002168 dimer interface [polypeptide binding]; other site 522373002169 phosphorylation site [posttranslational modification] 522373002170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373002171 ATP binding site [chemical binding]; other site 522373002172 G-X-G motif; other site 522373002173 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.4e-32 522373002174 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 4.6e-07 522373002175 HMMPfam hit to PF00672, HAMP domain, score 1.5e-10 522373002176 2 probable transmembrane helices predicted for Smlt0596 by TMHMM2.0 at aa 17-39 and 153-175 522373002177 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 522373002178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373002179 active site 522373002180 phosphorylation site [posttranslational modification] 522373002181 intermolecular recognition site; other site 522373002182 dimerization interface [polypeptide binding]; other site 522373002183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373002184 DNA binding site [nucleotide binding] 522373002185 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.3e-24 522373002186 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.7e-24 522373002187 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 522373002188 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 522373002189 active site 522373002190 dimer interface [polypeptide binding]; other site 522373002191 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 522373002192 Ligand Binding Site [chemical binding]; other site 522373002193 Molecular Tunnel; other site 522373002194 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 4.6e-05 522373002195 HMMPfam hit to PF00733, Asparagine synthase, score 1.9e-80 522373002196 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 522373002197 active site 522373002198 HMMPfam hit to PF01242, 6-pyruvoyl tetrahydropterin synthase, score 1.5e-52 522373002199 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373002200 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 522373002201 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373002202 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.5e-17 522373002203 HMMPfam hit to PF00593, TonB dependent receptor, score 6.6e-24 522373002204 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 522373002205 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 522373002206 putative active site [active] 522373002207 Zn binding site [ion binding]; other site 522373002208 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 522373002209 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 522373002210 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 522373002211 ATP binding site [chemical binding]; other site 522373002212 Mg++ binding site [ion binding]; other site 522373002213 motif III; other site 522373002214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373002215 nucleotide binding region [chemical binding]; other site 522373002216 ATP-binding site [chemical binding]; other site 522373002217 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.5e-31 522373002218 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.7e-69 522373002219 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 522373002220 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 522373002221 HMMPfam hit to PF01557, Fumarylacetoacetate (FAA) hydrolase fam, score 2.4e-05 522373002222 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 522373002223 maleylacetoacetate isomerase; Region: maiA; TIGR01262 522373002224 C-terminal domain interface [polypeptide binding]; other site 522373002225 GSH binding site (G-site) [chemical binding]; other site 522373002226 putative dimer interface [polypeptide binding]; other site 522373002227 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 522373002228 dimer interface [polypeptide binding]; other site 522373002229 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 522373002230 N-terminal domain interface [polypeptide binding]; other site 522373002231 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 6.5e-15 522373002232 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 522373002233 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 522373002234 Fe-S cluster binding site [ion binding]; other site 522373002235 active site 522373002236 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 2.1e-21 522373002237 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 522373002238 HMMPfam hit to PF04055, Radical SAM superfamily, score 2e-06 522373002239 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 522373002240 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 522373002241 ATP binding site [chemical binding]; other site 522373002242 Walker B motif; other site 522373002243 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 4.7e-12 522373002244 1 probable transmembrane helix predicted for Smlt0613 by TMHMM2.0 at aa 12-29 522373002245 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 522373002246 HMMPfam hit to PF00691, OmpA family, score 0.0002 522373002247 Protein of unknown function (DUF465); Region: DUF465; pfam04325 522373002248 HMMPfam hit to PF04325, Protein of unknown function (DUF465), score 1e-09 522373002249 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 522373002250 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 522373002251 dimer interface [polypeptide binding]; other site 522373002252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373002253 catalytic residue [active] 522373002254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 522373002255 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 3.4e-91 522373002256 HMMPfam hit to PF00571, CBS domain pair, score 1.3e-17 522373002257 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 522373002258 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 522373002259 homodimer interface [polypeptide binding]; other site 522373002260 substrate-cofactor binding pocket; other site 522373002261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373002262 catalytic residue [active] 522373002263 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 6.6e-257 522373002264 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 522373002265 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 522373002266 HMMPfam hit to PF01061, ABC-2 type transporter score 3.1e-40 522373002267 6 probable transmembrane helices predicted for Smlt0618 by TMHMM2.0 at aa 45-67, 82-104, 125-147, 162-184, 191-213 and 244-266 522373002268 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 522373002269 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 522373002270 Walker A/P-loop; other site 522373002271 ATP binding site [chemical binding]; other site 522373002272 Q-loop/lid; other site 522373002273 ABC transporter signature motif; other site 522373002274 Walker B; other site 522373002275 D-loop; other site 522373002276 H-loop/switch region; other site 522373002277 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 522373002278 putative carbohydrate binding site [chemical binding]; other site 522373002279 HMMPfam hit to PF00005, ABC transporter score 4e-41 522373002280 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 522373002281 trimer interface [polypeptide binding]; other site 522373002282 active site 522373002283 substrate binding site [chemical binding]; other site 522373002284 CoA binding site [chemical binding]; other site 522373002285 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 9.3 522373002286 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 9.2 522373002287 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.19 522373002288 Methyltransferase domain; Region: Methyltransf_24; pfam13578 522373002289 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 522373002290 putative ligand binding site [chemical binding]; other site 522373002291 putative catalytic site [active] 522373002292 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 522373002293 9 probable transmembrane helices predicted for Smlt0624 by TMHMM2.0 at aa 13-32, 83-102, 109-126, 156-178, 198-217, 250-269, 276-295, 300-319 and 326-348 522373002294 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 522373002295 active site 522373002296 catalytic triad [active] 522373002297 oxyanion hole [active] 522373002298 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 9.7e-05 522373002299 11 probable transmembrane helices predicted for Smlt0626 by TMHMM2.0 at aa 21-43, 68-87, 94-114, 124-146, 159-176, 180-197, 204-226, 256-274, 281-298, 302-320 and 327-349 522373002300 Predicted membrane protein [Function unknown]; Region: COG2246 522373002301 GtrA-like protein; Region: GtrA; pfam04138 522373002302 HMMPfam hit to PF04138, GtrA-like protein, score 1.2e-14 522373002303 4 probable transmembrane helices predicted for Smlt0627 by TMHMM2.0 at aa 13-32, 37-59, 72-94 and 109-126 522373002304 Predicted membrane protein [Function unknown]; Region: COG2246 522373002305 GtrA-like protein; Region: GtrA; pfam04138 522373002306 HMMPfam hit to PF04138, GtrA-like protein, score 2.7e-06 522373002307 4 probable transmembrane helices predicted for Smlt0628 by TMHMM2.0 at aa 10-32, 34-56, 76-98 and 110-127 522373002308 hypothetical protein; Provisional; Region: PRK07233 522373002309 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 522373002310 hydroxyglutarate oxidase; Provisional; Region: PRK11728 522373002311 HMMPfam hit to PF01593, Flavin containing amine oxidoreductase, score 6.4e-11 522373002312 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00037 522373002313 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 522373002314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373002315 NAD(P) binding site [chemical binding]; other site 522373002316 active site 522373002317 HMMPfam hit to PF04321, RmlD substrate binding domain, score 0.00023 522373002318 1 probable transmembrane helix predicted for Smlt0630 by TMHMM2.0 at aa 236-258 522373002319 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 1.1e-07 522373002320 HMMPfam hit to PF05368, NmrA-like family, score 0.0042 522373002321 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 1.3e-11 522373002322 HMMPfam hit to PF07993, Male sterility protein, score 6.8e-06 522373002323 Methyltransferase domain; Region: Methyltransf_23; pfam13489 522373002324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373002325 S-adenosylmethionine binding site [chemical binding]; other site 522373002326 HMMPfam hit to PF08241, Methyltransferase domain, score 1.9e-10 522373002327 HMMPfam hit to PF08242, Methyltransferase domain, score 5.7e-08 522373002328 short chain dehydrogenase; Provisional; Region: PRK07102 522373002329 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 522373002330 NAD(P) binding site [chemical binding]; other site 522373002331 active site 522373002332 1 probable transmembrane helix predicted for Smlt0632 by TMHMM2.0 at aa 216-238 522373002333 HMMPfam hit to PF00106, short chain dehydrogenase, score 4.9e-08 522373002334 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 522373002335 FAD binding domain; Region: FAD_binding_4; pfam01565 522373002336 HMMPfam hit to PF01565, FAD binding domain, score 7.4e-17 522373002337 hypothetical protein; Validated; Region: PRK08238 522373002338 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 522373002339 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 522373002340 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 3.9e-09 522373002341 8 probable transmembrane helices predicted for Smlt0634 by TMHMM2.0 at aa 28-47, 218-240, 260-282, 286-308, 329-351, 387-409, 421-440 and 450-472 522373002342 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 522373002343 7 probable transmembrane helices predicted for Smlt0635 by TMHMM2.0 at aa 13-32, 88-110, 117-139, 183-205, 212-234, 268-290 and 319-341 522373002344 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 522373002345 Ligand binding site; other site 522373002346 Putative Catalytic site; other site 522373002347 DXD motif; other site 522373002348 HMMPfam hit to PF00535, Glycosyl transferase family, score 0.0019 522373002349 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 522373002350 4 probable transmembrane helices predicted for Smlt0637 by TMHMM2.0 at aa 5-27, 42-64, 69-91 and 96-118 522373002351 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 1.4e-05 522373002352 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 522373002353 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 5.6e-17 522373002354 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 522373002355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373002356 NAD(P) binding site [chemical binding]; other site 522373002357 active site 522373002358 FAD dependent oxidoreductase; Region: DAO; pfam01266 522373002359 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 522373002360 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1e-06 522373002361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 522373002362 2 probable transmembrane helices predicted for Smlt0641 by TMHMM2.0 at aa 233-255 and 275-297 522373002363 HMMPfam hit to PF00535, Glycosyl transferase family, score 1.3e-05 522373002364 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 522373002365 HMMPfam hit to PF03706, Uncharacterised protein family (UPF0104), score 0.00015 522373002366 7 probable transmembrane helices predicted for Smlt0642 by TMHMM2.0 at aa 17-35, 45-67, 126-148, 152-174, 220-242, 257-279 and 292-314 522373002367 Sulfatase; Region: Sulfatase; cl17466 522373002368 HMMPfam hit to PF00884, Sulfatase, score 7.6e-13 522373002369 4 probable transmembrane helices predicted for Smlt0644 by TMHMM2.0 at aa 15-37, 50-72, 87-109 and 122-141 522373002370 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 522373002371 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 522373002372 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 522373002373 HMMPfam hit to PF00766, Electron transfer flavoprotein FAD-binding, score 1.2e-54 522373002374 HMMPfam hit to PF01012, Electron transfer flavoprotein domain, score 1.7e-30 522373002375 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 522373002376 Ligand binding site [chemical binding]; other site 522373002377 Electron transfer flavoprotein domain; Region: ETF; pfam01012 522373002378 HMMPfam hit to PF01012, Electron transfer flavoprotein domain, score 1.1e-59 522373002379 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 522373002380 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 522373002381 NAD binding site [chemical binding]; other site 522373002382 substrate binding site [chemical binding]; other site 522373002383 homodimer interface [polypeptide binding]; other site 522373002384 active site 522373002385 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.7e-05 522373002386 HMMPfam hit to PF04321, RmlD substrate binding domain, score 3.1e-07 522373002387 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 1.2e-92 522373002388 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 8.6e-06 522373002389 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 0.0003 522373002390 HMMPfam hit to PF07993, Male sterility protein, score 2.1e-07 522373002391 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 522373002392 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 522373002393 substrate binding site; other site 522373002394 tetramer interface; other site 522373002395 HMMPfam hit to PF00483, Nucleotidyl transferase, score 6.9e-110 522373002396 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 522373002397 HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose 3,5-epimerase, score 2.8e-108 522373002398 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 522373002399 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 522373002400 NADP binding site [chemical binding]; other site 522373002401 active site 522373002402 putative substrate binding site [chemical binding]; other site 522373002403 HMMPfam hit to PF04321, RmlD substrate binding domain, score 8e-160 522373002404 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 1.5e-07 522373002405 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 0.00021 522373002406 HMMPfam hit to PF07993, Male sterility protein, score 2.9e-05 522373002407 9 probable transmembrane helices predicted for Smlt0651 by TMHMM2.0 at aa 29-51, 114-136, 148-170, 208-230, 237-259, 286-308, 317-336, 351-370 and 377-399 522373002408 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 522373002409 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 522373002410 Substrate binding site; other site 522373002411 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 522373002412 HMMPfam hit to PF01050, Mannose-6-phosphate isomerase, score 4.9e-125 522373002413 HMMPfam hit to PF07883, Cupin domain, score 3.1e-13 522373002414 HMMPfam hit to PF00483, Nucleotidyl transferase, score 8.5e-126 522373002415 phosphomannomutase CpsG; Provisional; Region: PRK15414 522373002416 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 522373002417 active site 522373002418 substrate binding site [chemical binding]; other site 522373002419 metal binding site [ion binding]; metal-binding site 522373002420 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 3.2e-29 522373002421 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 3.4e-48 522373002422 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 5.2e-52 522373002423 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 1e-50 522373002424 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 522373002425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373002426 ATP binding site [chemical binding]; other site 522373002427 putative Mg++ binding site [ion binding]; other site 522373002428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373002429 nucleotide binding region [chemical binding]; other site 522373002430 ATP-binding site [chemical binding]; other site 522373002431 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.2e-22 522373002432 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 4.9e-74 522373002433 HMMPfam hit to PF04434, SWIM zinc finger, score 4e-05 522373002434 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 522373002435 HMMPfam hit to PF01144, Coenzyme A transferase, score 2e-110 522373002436 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 522373002437 HMMPfam hit to PF01144, Coenzyme A transferase, score 3.5e-56 522373002438 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 522373002439 putative ligand binding site [chemical binding]; other site 522373002440 putative catalytic site [active] 522373002441 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 522373002442 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 522373002443 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 0.0019 522373002444 Protein of unknown function (DUF330); Region: DUF330; cl01135 522373002445 HMMPfam hit to PF03886, Protein of unknown function (DUF330), score 2.5e-05 522373002446 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 522373002447 mce related protein; Region: MCE; pfam02470 522373002448 HMMPfam hit to PF02470, mce related protein, score 3.2e-18 522373002449 1 probable transmembrane helix predicted for Smlt0660 by TMHMM2.0 at aa 7-29 522373002450 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 522373002451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373002452 Walker A/P-loop; other site 522373002453 ATP binding site [chemical binding]; other site 522373002454 Q-loop/lid; other site 522373002455 ABC transporter signature motif; other site 522373002456 Walker B; other site 522373002457 D-loop; other site 522373002458 H-loop/switch region; other site 522373002459 HMMPfam hit to PF00005, ABC transporter score 1.7e-57 522373002460 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 522373002461 Permease; Region: Permease; pfam02405 522373002462 HMMPfam hit to PF02405, Domain of unknown function DUF140, score 1.1e-73 522373002463 5 probable transmembrane helices predicted for Smlt0662 by TMHMM2.0 at aa 168-190, 205-227, 261-283, 311-333 and 346-368 522373002464 Uncharacterized conserved protein [Function unknown]; Region: COG2966 522373002465 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 522373002466 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 522373002467 HMMPfam hit to PF06738, Protein of unknown function (DUF1212), score 6.2e-62 522373002468 8 probable transmembrane helices predicted for Smlt0663 by TMHMM2.0 at aa 151-173, 183-205, 210-232, 247-269, 282-299, 326-348, 355-377 and 392-414 522373002469 H-NS histone family; Region: Histone_HNS; pfam00816 522373002470 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 522373002471 HMMPfam hit to PF00816, H-NS histone family, score 2.1e-30 522373002472 prolyl-tRNA synthetase; Provisional; Region: PRK09194 522373002473 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 522373002474 dimer interface [polypeptide binding]; other site 522373002475 motif 1; other site 522373002476 active site 522373002477 motif 2; other site 522373002478 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 522373002479 putative deacylase active site [active] 522373002480 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 522373002481 active site 522373002482 motif 3; other site 522373002483 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 522373002484 anticodon binding site; other site 522373002485 HMMPfam hit to PF03129, Anticodon binding domain, score 1.4e-16 522373002486 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associa, score 1.5e-17 522373002487 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 5.9e-58 522373002488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373002489 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373002490 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373002491 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 4.3e-27 522373002492 HMMPfam hit to PF01548, Transposase, score 1.8e-06 522373002493 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 522373002494 1 probable transmembrane helix predicted for Smlt0668 by TMHMM2.0 at aa 15-37 522373002495 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 522373002496 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 522373002497 6 probable transmembrane helices predicted for Smlt0669 by TMHMM2.0 at aa 13-35, 104-126, 139-158, 173-195, 208-225 and 230-248 522373002498 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 2.4e-16 522373002499 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 522373002500 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 522373002501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373002502 Coenzyme A binding pocket [chemical binding]; other site 522373002503 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.2e-22 522373002504 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 522373002505 EamA-like transporter family; Region: EamA; pfam00892 522373002506 10 probable transmembrane helices predicted for Smlt0672 by TMHMM2.0 at aa 4-23, 30-52, 57-76, 89-107, 111-133, 140-159, 164-186, 199-221, 226-248 and 255-272 522373002507 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.8e-11 522373002508 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 522373002509 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 522373002510 active site 522373002511 HIGH motif; other site 522373002512 nucleotide binding site [chemical binding]; other site 522373002513 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 522373002514 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 522373002515 active site 522373002516 KMSKS motif; other site 522373002517 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 522373002518 tRNA binding surface [nucleotide binding]; other site 522373002519 anticodon binding site; other site 522373002520 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 522373002521 HMMPfam hit to PF08264, Anticodon-binding domain, score 6.9e-54 522373002522 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 1.9e-286 522373002523 DNA polymerase III subunit chi; Validated; Region: PRK05728 522373002524 HMMPfam hit to PF04364, DNA polymerase III chi subunit, HolC, score 1.7e-59 522373002525 multifunctional aminopeptidase A; Provisional; Region: PRK00913 522373002526 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 522373002527 interface (dimer of trimers) [polypeptide binding]; other site 522373002528 Substrate-binding/catalytic site; other site 522373002529 Zn-binding sites [ion binding]; other site 522373002530 HMMPfam hit to PF00883, Cytosol aminopeptidase family, cataly, score 2.8e-162 522373002531 HMMPfam hit to PF02789, Cytosol aminopeptidase family, N-term, score 4.4e-38 522373002532 Predicted permeases [General function prediction only]; Region: COG0795 522373002533 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 522373002534 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 1.5e-71 522373002535 6 probable transmembrane helices predicted for Smlt0676 by TMHMM2.0 at aa 13-35, 55-77, 102-124, 270-287, 299-321 and 325-347 522373002536 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 522373002537 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 522373002538 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 6.7e-76 522373002539 6 probable transmembrane helices predicted for Smlt0677 by TMHMM2.0 at aa 13-35, 68-90, 103-125, 286-308, 315-334 and 344-363 522373002540 RDD family; Region: RDD; pfam06271 522373002541 HMMPfam hit to PF06271, RDD family, score 3.3e-15 522373002542 3 probable transmembrane helices predicted for Smlt0679 by TMHMM2.0 at aa 34-56, 63-85 and 119-141 522373002543 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 522373002544 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 522373002545 active site 522373002546 DNA binding site [nucleotide binding] 522373002547 Int/Topo IB signature motif; other site 522373002548 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 1e-16 522373002549 HMMPfam hit to PF00589, Phage integrase family, score 1.4e-50 522373002550 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 522373002551 dimerization domain [polypeptide binding]; other site 522373002552 dimer interface [polypeptide binding]; other site 522373002553 catalytic residues [active] 522373002554 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 522373002555 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 522373002556 Interdomain contacts; other site 522373002557 Glyco_18 domain; Region: Glyco_18; smart00636 522373002558 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 522373002559 active site 522373002560 HMMPfam hit to PF00704, Glycosyl hydrolases family, score 3e-132 522373002561 HMMPfam hit to PF00041, Fibronectin type III domain, score 4.1e-12 522373002562 HMMPfam hit to PF00801, PKD domain, score 0.00013 522373002563 HMMPfam hit to PF02839, Carbohydrate binding domain, score 0.00016 522373002564 1 probable transmembrane helix predicted for Smlt0682 by TMHMM2.0 at aa 21-43 522373002565 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 522373002566 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 522373002567 dimerization interface [polypeptide binding]; other site 522373002568 ATP binding site [chemical binding]; other site 522373002569 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 522373002570 dimerization interface [polypeptide binding]; other site 522373002571 ATP binding site [chemical binding]; other site 522373002572 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 522373002573 putative active site [active] 522373002574 catalytic triad [active] 522373002575 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 2.9e-21 522373002576 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 3.8e-43 522373002577 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 1.3e-18 522373002578 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 522373002579 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 522373002580 trimer interface [polypeptide binding]; other site 522373002581 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 522373002582 trimer interface [polypeptide binding]; other site 522373002583 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 522373002584 trimer interface [polypeptide binding]; other site 522373002585 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 522373002586 trimer interface [polypeptide binding]; other site 522373002587 HMMPfam hit to PF05658, Hep_Hag, score 1.1e-05 522373002588 HMMPfam hit to PF05662, Haemagglutinin, score 7.4e-07 522373002589 HMMPfam hit to PF05658, Hep_Hag, score 0.7 522373002590 HMMPfam hit to PF05658, Hep_Hag, score 0.61 522373002591 HMMPfam hit to PF05658, Hep_Hag, score 2.5e-06 522373002592 HMMPfam hit to PF05658, Hep_Hag, score 0.003 522373002593 HMMPfam hit to PF05658, Hep_Hag, score 0.041 522373002594 HMMPfam hit to PF05662, Haemagglutinin, score 1.9e-06 522373002595 HMMPfam hit to PF05658, Hep_Hag, score 0.0035 522373002596 HMMPfam hit to PF05658, Hep_Hag, score 0.00014 522373002597 HMMPfam hit to PF05658, Hep_Hag, score 0.13 522373002598 HMMPfam hit to PF05658, Hep_Hag, score 4e-06 522373002599 HMMPfam hit to PF05658, Hep_Hag, score 0.0006 522373002600 HMMPfam hit to PF05658, Hep_Hag, score 1.4e-05 522373002601 HMMPfam hit to PF05658, Hep_Hag, score 4.8e-06 522373002602 HMMPfam hit to PF05662, Haemagglutinin, score 2.8e-05 522373002603 HMMPfam hit to PF05658, Hep_Hag, score 1.4 522373002604 HMMPfam hit to PF05658, Hep_Hag, score 3.4e-05 522373002605 HMMPfam hit to PF05658, Hep_Hag, score 0.19 522373002606 HMMPfam hit to PF05658, Hep_Hag, score 0.00073 522373002607 HMMPfam hit to PF05658, Hep_Hag, score 0.00016 522373002608 HMMPfam hit to PF05658, Hep_Hag, score 0.00015 522373002609 HMMPfam hit to PF05658, Hep_Hag, score 0.0043 522373002610 HMMPfam hit to PF05658, Hep_Hag, score 0.0013 522373002611 HMMPfam hit to PF05658, Hep_Hag, score 0.22 522373002612 HMMPfam hit to PF05662, Haemagglutinin, score 7.1e-07 522373002613 HMMPfam hit to PF05658, Hep_Hag, score 0.0063 522373002614 HMMPfam hit to PF05658, Hep_Hag, score 0.067 522373002615 HMMPfam hit to PF05658, Hep_Hag, score 0.003 522373002616 HMMPfam hit to PF05658, Hep_Hag, score 0.0015 522373002617 HMMPfam hit to PF05658, Hep_Hag, score 0.021 522373002618 HMMPfam hit to PF05658, Hep_Hag, score 0.00034 522373002619 HMMPfam hit to PF05658, Hep_Hag, score 0.00068 522373002620 HMMPfam hit to PF05658, Hep_Hag, score 8.1e-05 522373002621 HMMPfam hit to PF05658, Hep_Hag, score 0.0017 522373002622 HMMPfam hit to PF05662, Haemagglutinin, score 1.1e-06 522373002623 HMMPfam hit to PF05658, Hep_Hag, score 0.00067 522373002624 HMMPfam hit to PF05658, Hep_Hag, score 0.00014 522373002625 HMMPfam hit to PF05658, Hep_Hag, score 0.0056 522373002626 HMMPfam hit to PF05658, Hep_Hag, score 0.00027 522373002627 HMMPfam hit to PF05658, Hep_Hag, score 0.0038 522373002628 HMMPfam hit to PF05658, Hep_Hag, score 0.015 522373002629 HMMPfam hit to PF05658, Hep_Hag, score 2.2e-05 522373002630 HMMPfam hit to PF05658, Hep_Hag, score 0.00023 522373002631 HMMPfam hit to PF05662, Haemagglutinin, score 6.2e-06 522373002632 HMMPfam hit to PF05658, Hep_Hag, score 7.5e-05 522373002633 HMMPfam hit to PF05658, Hep_Hag, score 0.0012 522373002634 HMMPfam hit to PF05658, Hep_Hag, score 0.083 522373002635 HMMPfam hit to PF05658, Hep_Hag, score 0.0078 522373002636 HMMPfam hit to PF05658, Hep_Hag, score 0.0006 522373002637 HMMPfam hit to PF05658, Hep_Hag, score 0.0063 522373002638 HMMPfam hit to PF05662, Haemagglutinin, score 0.00028 522373002639 HMMPfam hit to PF05658, Hep_Hag, score 0.036 522373002640 HMMPfam hit to PF05658, Hep_Hag, score 0.003 522373002641 HMMPfam hit to PF05662, Haemagglutinin, score 1.5e-05 522373002642 HMMPfam hit to PF05658, Hep_Hag, score 9.8e-05 522373002643 HMMPfam hit to PF05658, Hep_Hag, score 0.00096 522373002644 HMMPfam hit to PF05662, Haemagglutinin, score 4.7e-07 522373002645 HMMPfam hit to PF03895, YadA-like C-terminal region, score 1.4e-16 522373002646 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 522373002647 active site 522373002648 catalytic triad [active] 522373002649 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 522373002650 1 probable transmembrane helix predicted for Smlt0686 by TMHMM2.0 at aa 7-29 522373002651 HMMPfam hit to PF00082, Subtilase family, score 1e-63 522373002652 HMMPfam hit to PF04151, Bacterial pre-peptidase C-terminal domai, score 8.2e-15 522373002653 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 522373002654 type II secretion system protein E; Region: type_II_gspE; TIGR02533 522373002655 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 522373002656 Walker A motif; other site 522373002657 ATP binding site [chemical binding]; other site 522373002658 Walker B motif; other site 522373002659 HMMPfam hit to PF05157, GSPII_E N-terminal domain, score 3.7e-26 522373002660 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 9.1e-145 522373002661 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 522373002662 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 522373002663 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 522373002664 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 7.2e-24 522373002665 3 probable transmembrane helices predicted for Smlt0688 by TMHMM2.0 at aa 172-194, 221-240 and 371-393 522373002666 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 1.1e-21 522373002667 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 522373002668 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 0.0067 522373002669 1 probable transmembrane helix predicted for Smlt0689 by TMHMM2.0 at aa 44-66 522373002670 HMMPfam hit to PF08334, Bacterial type II secretion system protein G, score 1.6e-38 522373002671 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 522373002672 1 probable transmembrane helix predicted for Smlt0690 by TMHMM2.0 at aa 21-43 522373002673 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 2e-05 522373002674 1 probable transmembrane helix predicted for Smlt0691 by TMHMM2.0 at aa 12-34 522373002675 general secretion pathway protein J; Validated; Region: PRK08808 522373002676 1 probable transmembrane helix predicted for Smlt0692 by TMHMM2.0 at aa 7-29 522373002677 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 522373002678 HMMPfam hit to PF03934, General secretion pathway protein K, score 8.4e-49 522373002679 1 probable transmembrane helix predicted for Smlt0693 by TMHMM2.0 at aa 7-29 522373002680 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 522373002681 HMMPfam hit to PF05137, Fimbrial assembly protein (PilN), score 8.3e-37 522373002682 1 probable transmembrane helix predicted for Smlt0694 by TMHMM2.0 at aa 213-232 522373002683 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 522373002684 1 probable transmembrane helix predicted for Smlt0695 by TMHMM2.0 at aa 12-34 522373002685 1 probable transmembrane helix predicted for Smlt0696 by TMHMM2.0 at aa 12-31 522373002686 type II secretion system protein D; Region: type_II_gspD; TIGR02517 522373002687 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 522373002688 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 522373002689 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 522373002690 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 522373002691 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 8.2e-10 522373002692 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.7e-09 522373002693 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 4.3e-12 522373002694 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 1.4e-68 522373002695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373002696 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373002697 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373002698 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 8.3e-25 522373002699 HMMPfam hit to PF01548, Transposase, score 1.8e-06 522373002700 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 522373002701 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 522373002702 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 522373002703 Probable Catalytic site; other site 522373002704 metal-binding site 522373002705 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 522373002706 HMMPfam hit to PF00535, Glycosyl transferase family, score 4.2e-23 522373002707 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 522373002708 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 522373002709 active site 522373002710 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase (NAPRTa, score 3.7e-115 522373002711 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 522373002712 HMMPfam hit to PF00419, Fimbrial protein, score 8.2e-31 522373002713 putative chaperone protein EcpD; Provisional; Region: PRK09926 522373002714 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 522373002715 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 522373002716 1 probable transmembrane helix predicted for Smlt0707 by TMHMM2.0 at aa 23-45 522373002717 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 3.6e-63 522373002718 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 1.2e-17 522373002719 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 522373002720 PapC N-terminal domain; Region: PapC_N; pfam13954 522373002721 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 522373002722 PapC C-terminal domain; Region: PapC_C; pfam13953 522373002723 HMMPfam hit to PF00577, Fimbrial Usher protein, score 2.2e-295 522373002724 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 522373002725 1 probable transmembrane helix predicted for Smlt0709 by TMHMM2.0 at aa 13-35 522373002726 HMMPfam hit to PF00419, Fimbrial protein, score 5.2e-15 522373002727 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 522373002728 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 522373002729 active site 522373002730 homodimer interface [polypeptide binding]; other site 522373002731 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 2e-132 522373002732 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 522373002733 1 probable transmembrane helix predicted for Smlt0711 by TMHMM2.0 at aa 701-723 522373002734 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 522373002735 active site 522373002736 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 522373002737 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 522373002738 2 probable transmembrane helices predicted for Smlt0712 by TMHMM2.0 at aa 10-32 and 367-389 522373002739 HMMPfam hit to PF05157, GSPII_E N-terminal domain, score 0.00064 522373002740 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 522373002741 hypothetical protein; Provisional; Region: PRK09936 522373002742 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 522373002743 HMMPfam hit to PF00916, Sulfate transporter family, score 0.0016 522373002744 10 probable transmembrane helices predicted for Smlt0715 by TMHMM2.0 at aa 27-49, 64-86, 93-112, 117-139, 146-163, 178-200, 207-224, 250-272, 340-362 and 401-423 522373002745 HMMPfam hit to PF00860, Permease family, score 9.2e-33 522373002746 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 522373002747 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 522373002748 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 522373002749 ABC transporter; Region: ABC_tran_2; pfam12848 522373002750 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 522373002751 HMMPfam hit to PF00005, ABC transporter score 1.8e-47 522373002752 HMMPfam hit to PF00005, ABC transporter score 7.5e-54 522373002753 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 522373002754 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 522373002755 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 522373002756 dimer interface [polypeptide binding]; other site 522373002757 active site 522373002758 glycine-pyridoxal phosphate binding site [chemical binding]; other site 522373002759 folate binding site [chemical binding]; other site 522373002760 HMMPfam hit to PF00464, Serine hydroxymethyltransferase, score 9.8e-272 522373002761 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.0004 522373002762 4 probable transmembrane helices predicted for Smlt0719 by TMHMM2.0 at aa 70-101, 116-138, 151-173 and 178-200 522373002763 3 probable transmembrane helices predicted for Smlt0720 by TMHMM2.0 at aa 29-51, 64-86 and 90-112 522373002764 4 probable transmembrane helices predicted for Smlt0721 by TMHMM2.0 at aa 13-35, 50-72, 85-107 and 117-136 522373002765 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 522373002766 ATP cone domain; Region: ATP-cone; pfam03477 522373002767 HMMPfam hit to PF03477, ATP cone domain, score 1.2e-27 522373002768 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 522373002769 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 522373002770 catalytic motif [active] 522373002771 Zn binding site [ion binding]; other site 522373002772 RibD C-terminal domain; Region: RibD_C; cl17279 522373002773 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 2.3e-37 522373002774 HMMPfam hit to PF01872, RibD C-terminal domain, score 6e-51 522373002775 1 probable transmembrane helix predicted for Smlt0724 by TMHMM2.0 at aa 19-36 522373002776 sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273 522373002777 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 522373002778 Lumazine binding domain; Region: Lum_binding; pfam00677 522373002779 Lumazine binding domain; Region: Lum_binding; pfam00677 522373002780 HMMPfam hit to PF00677, Lumazine binding domain, score 6.6e-19 522373002781 HMMPfam hit to PF00677, Lumazine binding domain, score 8.5e-28 522373002782 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 522373002783 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 522373002784 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 522373002785 dimerization interface [polypeptide binding]; other site 522373002786 active site 522373002787 HMMPfam hit to PF00926, 3,4-dihydroxy-2-butanone 4-phosphate, score 1.2e-115 522373002788 HMMPfam hit to PF00925, GTP cyclohydrolase II, score 1.2e-08 522373002789 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 522373002790 homopentamer interface [polypeptide binding]; other site 522373002791 active site 522373002792 HMMPfam hit to PF00885, 6,7-dimethyl-8-ribityllumazine synthase, score 7.5e-58 522373002793 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 522373002794 putative RNA binding site [nucleotide binding]; other site 522373002795 HMMPfam hit to PF01029, NusB family, score 1.9e-38 522373002796 thiamine monophosphate kinase; Provisional; Region: PRK05731 522373002797 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 522373002798 ATP binding site [chemical binding]; other site 522373002799 dimerization interface [polypeptide binding]; other site 522373002800 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 0.00051 522373002801 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 522373002802 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 522373002803 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 522373002804 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 1.4e-09 522373002805 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 7.1e-29 522373002806 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 522373002807 HMMPfam hit to PF00419, Fimbrial protein, score 1.2e-13 522373002808 Fimbrial protein; Region: Fimbrial; pfam00419 522373002809 HMMPfam hit to PF00419, Fimbrial protein, score 0.00045 522373002810 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 522373002811 PapC N-terminal domain; Region: PapC_N; pfam13954 522373002812 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 522373002813 PapC C-terminal domain; Region: PapC_C; pfam13953 522373002814 HMMPfam hit to PF00577, Fimbrial Usher protein, score 4.7e-249 522373002815 Fimbrial protein; Region: Fimbrial; pfam00419 522373002816 HMMPfam hit to PF00419, Fimbrial protein, score 0.012 522373002817 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 522373002818 HMMPfam hit to PF01757, Acyltransferase family, score 2.9e-60 522373002819 10 probable transmembrane helices predicted for Smlt0737 by TMHMM2.0 at aa 41-63, 86-108, 150-172, 185-202, 207-229, 242-261, 266-285, 292-314, 329-348 and 361-383 522373002820 FAD binding domain; Region: FAD_binding_4; pfam01565 522373002821 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 522373002822 HMMPfam hit to PF02913, FAD linked oxidases, C-terminal domain, score 1e-89 522373002823 HMMPfam hit to PF01565, FAD binding domain, score 1.6e-56 522373002824 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 522373002825 HMMPfam hit to PF04307, Predicted membrane-bound metal-dependent hyd, score 9.6e-18 522373002826 2 probable transmembrane helices predicted for Smlt0739 by TMHMM2.0 at aa 27-49 and 59-81 522373002827 hypothetical protein; Reviewed; Region: PRK12497 522373002828 HMMPfam hit to PF02021, Uncharacterised protein family UPF0102, score 1.5e-23 522373002829 LppC putative lipoprotein; Region: LppC; pfam04348 522373002830 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 522373002831 HMMPfam hit to PF04348, LppC putative lipoprotein, score 1.3e-117 522373002832 Predicted methyltransferases [General function prediction only]; Region: COG0313 522373002833 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 522373002834 putative SAM binding site [chemical binding]; other site 522373002835 putative homodimer interface [polypeptide binding]; other site 522373002836 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 4e-54 522373002837 Electron transfer DM13; Region: DM13; pfam10517 522373002838 1 probable transmembrane helix predicted for Smlt0745 by TMHMM2.0 at aa 7-29 522373002839 NRDE protein; Region: NRDE; pfam05742 522373002840 HMMPfam hit to PF05742, Protein of unknown function (DUF833), score 1.6e-98 522373002841 cell division protein MraZ; Reviewed; Region: PRK00326 522373002842 MraZ protein; Region: MraZ; pfam02381 522373002843 MraZ protein; Region: MraZ; pfam02381 522373002844 HMMPfam hit to PF02381, MraZ protein, score 2.6e-10 522373002845 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 522373002846 MraW methylase family; Region: Methyltransf_5; cl17771 522373002847 HMMPfam hit to PF01795, MraW methylase family, score 7.3e-137 522373002848 Cell division protein FtsL; Region: FtsL; pfam04999 522373002849 HMMPfam hit to PF04999, Cell division protein FtsL, score 3.8e-14 522373002850 1 probable transmembrane helix predicted for Smlt0749 by TMHMM2.0 at aa 4-23 522373002851 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 522373002852 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 522373002853 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 522373002854 1 probable transmembrane helix predicted for Smlt0750 by TMHMM2.0 at aa 21-43 522373002855 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 3.2e-56 522373002856 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.7e-99 522373002857 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 522373002858 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 522373002859 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 522373002860 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 522373002861 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 7.4e-12 522373002862 HMMPfam hit to PF08245, Mur ligase middle domain, score 7.1e-61 522373002863 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 2.3e-25 522373002864 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 522373002865 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 522373002866 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 522373002867 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 6.7e-19 522373002868 HMMPfam hit to PF08245, Mur ligase middle domain, score 9.8e-52 522373002869 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 3.6e-05 522373002870 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 522373002871 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 522373002872 Mg++ binding site [ion binding]; other site 522373002873 putative catalytic motif [active] 522373002874 putative substrate binding site [chemical binding]; other site 522373002875 10 probable transmembrane helices predicted for Smlt0753 by TMHMM2.0 at aa 21-43, 71-90, 97-114, 139-161, 168-187, 202-224, 236-258, 262-284, 289-311 and 339-358 522373002876 HMMPfam hit to PF00953, Glycosyl transferase family, score 6.9e-54 522373002877 cell division protein FtsW; Region: ftsW; TIGR02614 522373002878 HMMPfam hit to PF01098, Cell cycle protein, score 9.5e-117 522373002879 10 probable transmembrane helices predicted for Smlt0754 by TMHMM2.0 at aa 21-43, 48-70, 83-105, 120-137, 144-166, 170-189, 194-216, 279-301, 312-334 and 349-371 522373002880 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 522373002881 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 522373002882 active site 522373002883 homodimer interface [polypeptide binding]; other site 522373002884 HMMPfam hit to PF03033, Glycosyltransferase family, score 2.8e-39 522373002885 HMMPfam hit to PF04101, Glycosyltransferase family, score 1.9e-43 522373002886 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 522373002887 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 522373002888 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 522373002889 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 522373002890 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 6.5e-41 522373002891 HMMPfam hit to PF08245, Mur ligase middle domain, score 3.1e-36 522373002892 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 9.2e-24 522373002893 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 522373002894 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 522373002895 ATP-grasp domain; Region: ATP-grasp_4; cl17255 522373002896 HMMPfam hit to PF01820, D-ala D-ala ligase N-terminus, score 2.2e-28 522373002897 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 6.8e-78 522373002898 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 522373002899 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 522373002900 Cell division protein FtsQ; Region: FtsQ; pfam03799 522373002901 1 probable transmembrane helix predicted for Smlt0758 by TMHMM2.0 at aa 7-29 522373002902 HMMPfam hit to PF08478, POTRA domain, FtsQ-type, score 5.9e-24 522373002903 HMMPfam hit to PF03799, Cell division protein FtsQ, score 2.9e-22 522373002904 cell division protein FtsA; Region: ftsA; TIGR01174 522373002905 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 522373002906 nucleotide binding site [chemical binding]; other site 522373002907 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 522373002908 Cell division protein FtsA; Region: FtsA; pfam14450 522373002909 HMMPfam hit to PF02491, Cell division protein FtsA, score 2.3e-82 522373002910 HMMPfam hit to PF02491, Cell division protein FtsA, score 3.1e-73 522373002911 cell division protein FtsZ; Validated; Region: PRK09330 522373002912 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 522373002913 nucleotide binding site [chemical binding]; other site 522373002914 SulA interaction site; other site 522373002915 HMMPfam hit to PF00091, Tubulin/FtsZ family, GTPase domain, score 3.4e-96 522373002916 HMMPfam hit to PF03953, Tubulin/FtsZ family, C-terminal domain, score 1.8e-39 522373002917 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 522373002918 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 522373002919 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglycosamine deacetylase, score 5.3e-146 522373002920 Protein of unknown function (DUF721); Region: DUF721; cl02324 522373002921 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 522373002922 Peptidase family M23; Region: Peptidase_M23; pfam01551 522373002923 1 probable transmembrane helix predicted for Smlt0763 by TMHMM2.0 at aa 34-56 522373002924 HMMPfam hit to PF01551, Peptidase family M23, score 1.5e-48 522373002925 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 522373002926 DEAD/DEAH box helicase; Region: DEAD; pfam00270 522373002927 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 522373002928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 522373002929 nucleotide binding region [chemical binding]; other site 522373002930 ATP-binding site [chemical binding]; other site 522373002931 SEC-C motif; Region: SEC-C; pfam02810 522373002932 HMMPfam hit to PF07517, SecA DEAD-like domain, score 1.3e-224 522373002933 HMMPfam hit to PF01043, SecA preprotein cross-linking domain, score 9.5e-76 522373002934 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 0.022 522373002935 HMMPfam hit to PF07516, SecA Wing and Scaffold domain, score 6.9e-86 522373002936 HMMPfam hit to PF02810, SEC-C motif, score 1.9e-10 522373002937 hypothetical protein; Provisional; Region: PRK08999 522373002938 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 522373002939 active site 522373002940 8-oxo-dGMP binding site [chemical binding]; other site 522373002941 nudix motif; other site 522373002942 metal binding site [ion binding]; metal-binding site 522373002943 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 522373002944 thiamine phosphate binding site [chemical binding]; other site 522373002945 active site 522373002946 pyrophosphate binding site [ion binding]; other site 522373002947 HMMPfam hit to PF00293, NUDIX domain, score 3.1e-22 522373002948 HMMPfam hit to PF02581, Thiamine monophosphate synthase/TENI, score 1.1e-42 522373002949 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 522373002950 FAD binding site [chemical binding]; other site 522373002951 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 1.5e-89 522373002952 1 probable transmembrane helix predicted for Smlt0768 by TMHMM2.0 at aa 9-31 522373002953 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373002954 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 0.00046 522373002955 Histidine kinase; Region: His_kinase; pfam06580 522373002956 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 522373002957 ATP binding site [chemical binding]; other site 522373002958 Mg2+ binding site [ion binding]; other site 522373002959 G-X-G motif; other site 522373002960 3 probable transmembrane helices predicted for Smlt0769 by TMHMM2.0 at aa 4-22, 34-56 and 79-101 522373002961 HMMPfam hit to PF06580, Histidine kinase, score 5e-30 522373002962 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 522373002963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373002964 active site 522373002965 phosphorylation site [posttranslational modification] 522373002966 intermolecular recognition site; other site 522373002967 dimerization interface [polypeptide binding]; other site 522373002968 LytTr DNA-binding domain; Region: LytTR; smart00850 522373002969 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.3e-29 522373002970 HMMPfam hit to PF04397, LytTr DNA-binding domain, score 5.5e-20 522373002971 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 522373002972 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 522373002973 Amidohydrolase; Region: Amidohydro_4; pfam13147 522373002974 active site 522373002975 HMMPfam hit to PF01979, Amidohydrolase family, score 1.6e-05 522373002976 1 probable transmembrane helix predicted for Smlt0771 by TMHMM2.0 at aa 19-41 522373002977 Protein of unknown function (DUF3228); Region: DUF3228; pfam11539 522373002978 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 522373002979 putative deacylase active site [active] 522373002980 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associated do, score 1.5e-64 522373002981 Adenosylhomocysteinase; Provisional; Region: PTZ00075 522373002982 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 522373002983 homotetramer interface [polypeptide binding]; other site 522373002984 ligand binding site [chemical binding]; other site 522373002985 catalytic site [active] 522373002986 NAD binding site [chemical binding]; other site 522373002987 HMMPfam hit to PF05221, S-adenosyl-L-homocysteine hydrolase, score 5.8e-204 522373002988 HMMPfam hit to PF00670, S-adenosyl-L-homocysteine hydrolase, NA, score 4.8e-109 522373002989 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 522373002990 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373002991 1 probable transmembrane helix predicted for Smlt0777 by TMHMM2.0 at aa 31-50 522373002992 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 2.1e-16 522373002993 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 522373002994 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 522373002995 HMMPfam hit to PF00311, Phosphoenolpyruvate carboxylase, score 4.3e-62 522373002996 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 522373002997 HMMPfam hit to PF03061, Thioesterase superfamily, score 6e-16 522373002998 S-adenosylmethionine synthetase; Validated; Region: PRK05250 522373002999 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 522373003000 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 522373003001 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 522373003002 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, C-te, score 9.4e-86 522373003003 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, cent, score 5.1e-67 522373003004 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, N-te, score 1.3e-53 522373003005 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 522373003006 putative acyl-acceptor binding pocket; other site 522373003007 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 522373003008 HMMPfam hit to PF01553, Acyltransferase, score 3.5e-08 522373003009 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 522373003010 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 522373003011 putative active site [active] 522373003012 putative metal binding site [ion binding]; other site 522373003013 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 2.6e-06 522373003014 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 522373003015 HMMPfam hit to PF04307, Predicted membrane-bound metal-dependent hyd, score 1.5e-15 522373003016 4 probable transmembrane helices predicted for Smlt0783 by TMHMM2.0 at aa 60-79, 92-114, 129-151 and 158-180 522373003017 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 522373003018 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 522373003019 Ligand binding site; other site 522373003020 Putative Catalytic site; other site 522373003021 DXD motif; other site 522373003022 2 probable transmembrane helices predicted for Smlt0784 by TMHMM2.0 at aa 255-277 and 292-314 522373003023 HMMPfam hit to PF00535, Glycosyl transferase family, score 3.1e-12 522373003024 14 probable transmembrane helices predicted for Smlt0785 by TMHMM2.0 at aa 48-70, 152-174, 181-203, 208-227, 239-261, 276-298, 310-332, 347-364, 377-399, 414-434, 441-458, 468-485, 490-512 and 548-570 522373003025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373003026 S-adenosylmethionine binding site [chemical binding]; other site 522373003027 HMMPfam hit to PF08241, Methyltransferase domain, score 2.5e-33 522373003028 HMMPfam hit to PF08242, Methyltransferase domain, score 6.3e-22 522373003029 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 522373003030 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 522373003031 FMN binding site [chemical binding]; other site 522373003032 active site 522373003033 catalytic residues [active] 522373003034 substrate binding site [chemical binding]; other site 522373003035 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 9.1e-132 522373003036 4 probable transmembrane helices predicted for Smlt0788 by TMHMM2.0 at aa 25-47, 67-89, 104-126 and 135-157 522373003037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373003038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373003039 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 522373003040 putative effector binding pocket; other site 522373003041 putative dimerization interface [polypeptide binding]; other site 522373003042 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.1e-35 522373003043 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.4e-21 522373003044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373003045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373003046 putative substrate translocation pore; other site 522373003047 12 probable transmembrane helices predicted for Smlt0790 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 145-167, 172-194, 217-239, 254-271, 278-300, 305-327, 340-362 and 367-389 522373003048 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.5e-44 522373003049 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 522373003050 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 522373003051 substrate binding site [chemical binding]; other site 522373003052 dimer interface [polypeptide binding]; other site 522373003053 ATP binding site [chemical binding]; other site 522373003054 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 5.1e-47 522373003055 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 522373003056 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 522373003057 Nucleoside recognition; Region: Gate; pfam07670 522373003058 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 522373003059 8 probable transmembrane helices predicted for Smlt0792 by TMHMM2.0 at aa 5-27, 34-56, 95-117, 173-195, 270-292, 305-327, 371-393 and 406-428 522373003060 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 5.9e-106 522373003061 HMMPfam hit to PF07670, Nucleoside recognition, score 4.9e-16 522373003062 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 2.7e-28 522373003063 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 522373003064 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 522373003065 active site 522373003066 catalytic tetrad [active] 522373003067 HMMPfam hit to PF00248, Aldo/keto reductase family, score 5.1e-69 522373003068 Hemin uptake protein hemP; Region: hemP; pfam10636 522373003069 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 522373003070 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373003071 N-terminal plug; other site 522373003072 ligand-binding site [chemical binding]; other site 522373003073 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.5e-23 522373003074 HMMPfam hit to PF00593, TonB dependent receptor, score 1e-32 522373003075 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 522373003076 FtsX-like permease family; Region: FtsX; pfam02687 522373003077 HMMPfam hit to PF02687, Predicted permease, score 1.2e-22 522373003078 10 probable transmembrane helices predicted for Smlt0798 by TMHMM2.0 at aa 36-58, 277-299, 320-342, 370-392, 405-427, 437-459, 491-513, 733-755, 783-805 and 820-842 522373003079 HMMPfam hit to PF02687, Predicted permease, score 7.1e-16 522373003080 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 522373003081 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 522373003082 Walker A/P-loop; other site 522373003083 ATP binding site [chemical binding]; other site 522373003084 Q-loop/lid; other site 522373003085 ABC transporter signature motif; other site 522373003086 Walker B; other site 522373003087 D-loop; other site 522373003088 H-loop/switch region; other site 522373003089 HMMPfam hit to PF00005, ABC transporter score 4.5e-59 522373003090 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 522373003091 active site 522373003092 catalytic triad [active] 522373003093 oxyanion hole [active] 522373003094 switch loop; other site 522373003095 1 probable transmembrane helix predicted for Smlt0800 by TMHMM2.0 at aa 13-35 522373003096 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 2.2e-21 522373003097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373003098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373003099 active site 522373003100 phosphorylation site [posttranslational modification] 522373003101 intermolecular recognition site; other site 522373003102 dimerization interface [polypeptide binding]; other site 522373003103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373003104 DNA binding site [nucleotide binding] 522373003105 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.7e-38 522373003106 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 5.1e-20 522373003107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373003108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373003109 dimer interface [polypeptide binding]; other site 522373003110 phosphorylation site [posttranslational modification] 522373003111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373003112 ATP binding site [chemical binding]; other site 522373003113 Mg2+ binding site [ion binding]; other site 522373003114 G-X-G motif; other site 522373003115 2 probable transmembrane helices predicted for Smlt0802 by TMHMM2.0 at aa 13-35 and 125-147 522373003116 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 7.2e-14 522373003117 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.1e-29 522373003118 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 522373003119 active site 522373003120 catalytic triad [active] 522373003121 oxyanion hole [active] 522373003122 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 8e-07 522373003123 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 522373003124 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 6.4e-34 522373003125 2 probable transmembrane helices predicted for Smlt0804 by TMHMM2.0 at aa 68-90 and 111-133 522373003126 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 522373003127 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 1.6e-32 522373003128 7 probable transmembrane helices predicted for Smlt0805 by TMHMM2.0 at aa 15-37, 50-72, 77-99, 131-153, 157-179, 186-205 and 215-233 522373003129 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 522373003130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373003131 putative substrate translocation pore; other site 522373003132 12 probable transmembrane helices predicted for Smlt0806 by TMHMM2.0 at aa 5-27, 37-59, 72-91, 101-123, 130-152, 162-184, 204-226, 236-258, 271-288, 293-315, 327-349 and 353-375 522373003133 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.9e-40 522373003134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373003135 Transposase; Region: HTH_Tnp_1; cl17663 522373003136 HMMPfam hit to PF01527, Transposase, score 0.00031 522373003137 putative transposase OrfB; Reviewed; Region: PHA02517 522373003138 HTH-like domain; Region: HTH_21; pfam13276 522373003139 Integrase core domain; Region: rve; pfam00665 522373003140 Integrase core domain; Region: rve_2; pfam13333 522373003141 HMMPfam hit to PF00665, Integrase core domain, score 1.9e-41 522373003142 LemA family; Region: LemA; pfam04011 522373003143 HMMPfam hit to PF04011, LemA family, score 1.5e-102 522373003144 Repair protein; Region: Repair_PSII; pfam04536 522373003145 HMMPfam hit to PF04536, Domain of unknown function (DUF477), score 8.1e-54 522373003146 2 probable transmembrane helices predicted for Smlt0810 by TMHMM2.0 at aa 181-200 and 221-243 522373003147 Repair protein; Region: Repair_PSII; pfam04536 522373003148 HMMPfam hit to PF04536, Domain of unknown function (DUF477), score 2.4e-32 522373003149 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 522373003150 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 3.9e-116 522373003151 7 probable transmembrane helices predicted for Smlt0812 by TMHMM2.0 at aa 20-37, 58-80, 95-114, 127-149, 197-216, 223-240 and 255-277 522373003152 thymidylate synthase; Reviewed; Region: thyA; PRK01827 522373003153 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 522373003154 dimerization interface [polypeptide binding]; other site 522373003155 active site 522373003156 HMMPfam hit to PF00303, Thymidylate synthase, score 1.7e-152 522373003157 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 522373003158 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 522373003159 folate binding site [chemical binding]; other site 522373003160 NADP+ binding site [chemical binding]; other site 522373003161 HMMPfam hit to PF00186, Dihydrofolate reductase, score 2.4e-57 522373003162 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 522373003163 HMMPfam hit to PF06940, Protein of unknown function (DUF1287), score 8.4e-97 522373003164 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 522373003165 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 522373003166 active site 522373003167 metal binding site [ion binding]; metal-binding site 522373003168 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 7.4e-14 522373003169 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 522373003170 HMMPfam hit to PF04379, Protein of unknown function (DUF525), score 2.6e-65 522373003171 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 522373003172 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 522373003173 HMMPfam hit to PF00398, Ribosomal RNA adenine dimethylase, score 2.3e-69 522373003174 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 522373003175 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 522373003176 HMMPfam hit to PF04166, Pyridoxal phosphate biosynthetic protein Pdx, score 4.6e-138 522373003177 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 522373003178 SurA N-terminal domain; Region: SurA_N; pfam09312 522373003179 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 522373003180 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 522373003181 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 8.8e-28 522373003182 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 3.1e-15 522373003183 organic solvent tolerance protein; Provisional; Region: PRK04423 522373003184 Organic solvent tolerance protein; Region: OstA_C; pfam04453 522373003185 HMMPfam hit to PF04453, Organic solvent tolerance protein, score 1.9e-109 522373003186 HMMPfam hit to PF03968, OstA-like protein, score 0.0017 522373003187 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 522373003188 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 522373003189 putative active site [active] 522373003190 Zn binding site [ion binding]; other site 522373003191 HMMPfam hit to PF00850, Histone deacetylase domain, score 2.4e-80 522373003192 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 522373003193 HMMPfam hit to PF01923, Cobalamin adenosyltransferase, score 3.7e-87 522373003194 5 probable transmembrane helices predicted for Smlt0824 by TMHMM2.0 at aa 23-45, 50-67, 82-104, 116-138 and 161-183 522373003195 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 522373003196 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 522373003197 HMMPfam hit to PF01494, FAD binding domain, score 6.8e-10 522373003198 1 probable transmembrane helix predicted for Smlt0825 by TMHMM2.0 at aa 7-24 522373003199 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Validated; Region: PRK08773 522373003200 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 522373003201 HMMPfam hit to PF01494, FAD binding domain, score 5.1e-11 522373003202 1 probable transmembrane helix predicted for Smlt0826 by TMHMM2.0 at aa 13-35 522373003203 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.9e-06 522373003204 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 522373003205 EF-hand domain pair; Region: EF_hand_5; pfam13499 522373003206 pseudo EF-hand loop; other site 522373003207 peptide binding pocket; other site 522373003208 Ca2+ binding site [ion binding]; other site 522373003209 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 522373003210 FtsJ-like methyltransferase; Region: FtsJ; cl17430 522373003211 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 522373003212 nucleoside/Zn binding site; other site 522373003213 dimer interface [polypeptide binding]; other site 522373003214 catalytic motif [active] 522373003215 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 3.1e-07 522373003216 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 522373003217 2 probable transmembrane helices predicted for Smlt0831 by TMHMM2.0 at aa 10-32 and 39-61 522373003218 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 522373003219 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 522373003220 active site 522373003221 HIGH motif; other site 522373003222 nucleotide binding site [chemical binding]; other site 522373003223 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 522373003224 active site 522373003225 KMSKS motif; other site 522373003226 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 522373003227 HMMPfam hit to PF03950, tRNA synthetases class I (E and Q), an, score 5.2e-92 522373003228 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), ca, score 2.6e-125 522373003229 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 522373003230 methionine sulfoxide reductase A; Provisional; Region: PRK00058 522373003231 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 4.9e-97 522373003232 putative transposase OrfB; Reviewed; Region: PHA02517 522373003233 HTH-like domain; Region: HTH_21; pfam13276 522373003234 Integrase core domain; Region: rve; pfam00665 522373003235 Integrase core domain; Region: rve_2; pfam13333 522373003236 HMMPfam hit to PF00665, Integrase core domain, score 7.3e-43 522373003237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373003238 Transposase; Region: HTH_Tnp_1; cl17663 522373003239 HMMPfam hit to PF01527, Transposase, score 0.00054 522373003240 transaldolase-like protein; Provisional; Region: PTZ00411 522373003241 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 522373003242 active site 522373003243 dimer interface [polypeptide binding]; other site 522373003244 catalytic residue [active] 522373003245 HMMPfam hit to PF00923, Transaldolase, score 7.5e-120 522373003246 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 522373003247 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 522373003248 HMMPfam hit to PF01272, Prokaryotic transcription elongation factor, score 0.00072 522373003249 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 522373003250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373003251 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 522373003252 dimerization interface [polypeptide binding]; other site 522373003253 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.9e-53 522373003254 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.9e-23 522373003255 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 522373003256 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 522373003257 catalytic residue [active] 522373003258 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 522373003259 catalytic residues [active] 522373003260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373003261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373003262 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 2.4e-46 522373003263 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 3.4e-22 522373003264 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 0.0017 522373003265 peroxiredoxin; Region: AhpC; TIGR03137 522373003266 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 522373003267 dimer interface [polypeptide binding]; other site 522373003268 decamer (pentamer of dimers) interface [polypeptide binding]; other site 522373003269 catalytic triad [active] 522373003270 peroxidatic and resolving cysteines [active] 522373003271 HMMPfam hit to PF00578, AhpC/TSA family, score 1e-72 522373003272 HMMPfam hit to PF08534, Redoxin, score 4.2e-09 522373003273 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 522373003274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373003275 S-adenosylmethionine binding site [chemical binding]; other site 522373003276 HMMPfam hit to PF05175, Methyltransferase small domain, score 2.9e-09 522373003277 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 522373003278 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 2.3e-28 522373003279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373003280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373003281 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373003282 putative effector binding pocket; other site 522373003283 dimerization interface [polypeptide binding]; other site 522373003284 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.9e-46 522373003285 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.3e-18 522373003286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373003287 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 522373003288 14 probable transmembrane helices predicted for Smlt0845 by TMHMM2.0 at aa 25-47, 62-84, 97-119, 123-145, 152-174, 179-201, 213-235, 240-262, 283-305, 315-334, 347-366, 376-398, 419-438 and 453-471 522373003289 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.3e-56 522373003290 N-formylglutamate amidohydrolase; Region: FGase; cl01522 522373003291 HMMPfam hit to PF05013, N-formylglutamate amidohydrolase, score 2.3e-69 522373003292 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 522373003293 ADP-ribose binding site [chemical binding]; other site 522373003294 dimer interface [polypeptide binding]; other site 522373003295 active site 522373003296 nudix motif; other site 522373003297 metal binding site [ion binding]; metal-binding site 522373003298 HMMPfam hit to PF00293, NUDIX domain, score 2.2e-12 522373003299 5'-3' exonuclease; Region: 53EXOc; smart00475 522373003300 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 522373003301 active site 522373003302 metal binding site 1 [ion binding]; metal-binding site 522373003303 putative 5' ssDNA interaction site; other site 522373003304 metal binding site 3; metal-binding site 522373003305 metal binding site 2 [ion binding]; metal-binding site 522373003306 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 522373003307 putative DNA binding site [nucleotide binding]; other site 522373003308 putative metal binding site [ion binding]; other site 522373003309 HMMPfam hit to PF01367, 5'-3' exonuclease, C-terminal SAM fold, score 1.1e-33 522373003310 HMMPfam hit to PF02739, 5'-3' exonuclease, N-terminal resolvase-, score 8.9e-36 522373003311 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 522373003312 putative FMN binding site [chemical binding]; other site 522373003313 HMMPfam hit to PF00881, Nitroreductase family, score 1.1e-06 522373003314 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 522373003315 HMMPfam hit to PF07793, Protein of unknown function (DUF1631), score 2.5e-301 522373003316 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 522373003317 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 522373003318 ligand binding site [chemical binding]; other site 522373003319 homodimer interface [polypeptide binding]; other site 522373003320 NAD(P) binding site [chemical binding]; other site 522373003321 trimer interface B [polypeptide binding]; other site 522373003322 trimer interface A [polypeptide binding]; other site 522373003323 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT, N-terminal dom, score 2.3e-29 522373003324 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT, C-terminal dom, score 4.2e-74 522373003325 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 522373003326 1 probable transmembrane helix predicted for Smlt0854 by TMHMM2.0 at aa 45-67 522373003327 RNA polymerase factor sigma-70; Validated; Region: PRK09047 522373003328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373003329 DNA binding residues [nucleotide binding] 522373003330 HMMPfam hit to PF04545, Sigma-70, region, score 1.1e-12 522373003331 HMMPfam hit to PF08281, Sigma-70, region, score 2.2e-18 522373003332 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 522373003333 3 probable transmembrane helices predicted for Smlt0856 by TMHMM2.0 at aa 5-22, 35-57 and 62-81 522373003334 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 522373003335 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 522373003336 HMMPfam hit to PF02233, NAD(P) transhydrogenase beta subunit, score 4.4e-166 522373003337 8 probable transmembrane helices predicted for Smlt0857 by TMHMM2.0 at aa 11-28, 40-59, 64-83, 96-118, 144-166, 187-204, 208-230 and 251-273 522373003338 4 probable transmembrane helices predicted for Smlt0858 by TMHMM2.0 at aa 28-50, 60-78, 85-107 and 127-149 522373003339 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 522373003340 HMMPfam hit to PF01883, Domain of unknown function DUF59, score 1.2e-18 522373003341 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 522373003342 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 522373003343 homodimer interface [polypeptide binding]; other site 522373003344 substrate-cofactor binding pocket; other site 522373003345 catalytic residue [active] 522373003346 HMMPfam hit to PF01063, Aminotransferase class IV, score 2.6e-120 522373003347 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 522373003348 active site 522373003349 catalytic triad [active] 522373003350 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 522373003351 1 probable transmembrane helix predicted for Smlt0861 by TMHMM2.0 at aa 12-31 522373003352 HMMPfam hit to PF00082, Subtilase family, score 5e-107 522373003353 HMMPfam hit to PF04151, Bacterial pre-peptidase C-terminal domai, score 3.2e-22 522373003354 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 522373003355 active site 522373003356 4 probable transmembrane helices predicted for Smlt0863 by TMHMM2.0 at aa 7-25, 30-52, 57-76 and 81-103 522373003357 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 522373003358 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373003359 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 0.00082 522373003360 HMMPfam hit to PF00258, Flavodoxin, score 0.0003 522373003361 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 522373003362 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 522373003363 HMMPfam hit to PF03631, Ribonuclease BN-like family, score 7.1e-55 522373003364 6 probable transmembrane helices predicted for Smlt0865 by TMHMM2.0 at aa 59-81, 121-143, 163-185, 200-222, 235-257 and 272-294 522373003365 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 522373003366 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373003367 catalytic residues [active] 522373003368 HMMPfam hit to PF08534, Redoxin, score 1.3e-13 522373003369 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 522373003370 HMMPfam hit to PF03976, Polyphosphate kinase, score 3.8e-125 522373003371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373003372 TPR repeat; Region: TPR_11; pfam13414 522373003373 binding surface 522373003374 TPR motif; other site 522373003375 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 522373003376 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0033 522373003377 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.045 522373003378 peptide chain release factor 1; Validated; Region: prfA; PRK00591 522373003379 This domain is found in peptide chain release factors; Region: PCRF; smart00937 522373003380 RF-1 domain; Region: RF-1; pfam00472 522373003381 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 1.7e-71 522373003382 HMMPfam hit to PF03462, PCRF domain, score 4.7e-62 522373003383 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 522373003384 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 522373003385 tRNA; other site 522373003386 putative tRNA binding site [nucleotide binding]; other site 522373003387 putative NADP binding site [chemical binding]; other site 522373003388 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 522373003389 HMMPfam hit to PF00745, Glutamyl-tRNAGlu reductase, dimerisation, score 1.2e-29 522373003390 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 1.1e-64 522373003391 HMMPfam hit to PF05201, Glutamyl-tRNAGlu reductase, N-terminal d, score 4.9e-81 522373003392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373003393 TPR motif; other site 522373003394 binding surface 522373003395 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 522373003396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373003397 binding surface 522373003398 TPR motif; other site 522373003399 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.45 522373003400 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 8.2e-06 522373003401 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 522373003402 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 522373003403 HMMPfam hit to PF03550, Outer membrane lipoprotein LolB, score 4.7e-54 522373003404 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 522373003405 HMMPfam hit to PF00288, GHMP kinases N terminal domain, score 2.6e-17 522373003406 HMMPfam hit to PF08544, GHMP kinases C terminal, score 6e-05 522373003407 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 522373003408 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 522373003409 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 522373003410 active site 522373003411 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 8.1e-32 522373003412 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 522373003413 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 522373003414 5S rRNA interface [nucleotide binding]; other site 522373003415 CTC domain interface [polypeptide binding]; other site 522373003416 L16 interface [polypeptide binding]; other site 522373003417 HMMPfam hit to PF01386, Ribosomal L25p family, score 2e-28 522373003418 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 522373003419 putative active site [active] 522373003420 catalytic residue [active] 522373003421 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase, score 5.2e-75 522373003422 GTP-binding protein YchF; Reviewed; Region: PRK09601 522373003423 YchF GTPase; Region: YchF; cd01900 522373003424 G1 box; other site 522373003425 GTP/Mg2+ binding site [chemical binding]; other site 522373003426 Switch I region; other site 522373003427 G2 box; other site 522373003428 Switch II region; other site 522373003429 G3 box; other site 522373003430 G4 box; other site 522373003431 G5 box; other site 522373003432 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 522373003433 HMMPfam hit to PF01926, GTPase of unknown function, score 3.1e-33 522373003434 HMMPfam hit to PF06071, Protein of unknown function (DUF933), score 4.2e-60 522373003435 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 522373003436 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 522373003437 Autotransporter beta-domain; Region: Autotransporter; pfam03797 522373003438 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.6e-21 522373003439 HMMPfam hit to PF03212, Pertactin, score 5.8e-07 522373003440 transcriptional regulator RcsB; Provisional; Region: PRK10840 522373003441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373003442 active site 522373003443 phosphorylation site [posttranslational modification] 522373003444 intermolecular recognition site; other site 522373003445 dimerization interface [polypeptide binding]; other site 522373003446 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373003447 DNA binding residues [nucleotide binding] 522373003448 dimerization interface [polypeptide binding]; other site 522373003449 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.6e-18 522373003450 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.6e-21 522373003451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373003452 dimer interface [polypeptide binding]; other site 522373003453 phosphorylation site [posttranslational modification] 522373003454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373003455 ATP binding site [chemical binding]; other site 522373003456 Mg2+ binding site [ion binding]; other site 522373003457 G-X-G motif; other site 522373003458 Response regulator receiver domain; Region: Response_reg; pfam00072 522373003459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373003460 active site 522373003461 phosphorylation site [posttranslational modification] 522373003462 intermolecular recognition site; other site 522373003463 dimerization interface [polypeptide binding]; other site 522373003464 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 522373003465 putative binding surface; other site 522373003466 active site 522373003467 HMMPfam hit to PF01627, Hpt domain, score 1.6e-08 522373003468 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-30 522373003469 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.5e-36 522373003470 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.4e-25 522373003471 Response regulator receiver domain; Region: Response_reg; pfam00072 522373003472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373003473 active site 522373003474 phosphorylation site [posttranslational modification] 522373003475 intermolecular recognition site; other site 522373003476 dimerization interface [polypeptide binding]; other site 522373003477 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373003478 HMMPfam hit to PF00563, EAL domain, score 6.8e-56 522373003479 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.9e-12 522373003480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373003481 dimer interface [polypeptide binding]; other site 522373003482 phosphorylation site [posttranslational modification] 522373003483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373003484 ATP binding site [chemical binding]; other site 522373003485 Mg2+ binding site [ion binding]; other site 522373003486 G-X-G motif; other site 522373003487 Response regulator receiver domain; Region: Response_reg; pfam00072 522373003488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373003489 active site 522373003490 phosphorylation site [posttranslational modification] 522373003491 intermolecular recognition site; other site 522373003492 dimerization interface [polypeptide binding]; other site 522373003493 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.5e-36 522373003494 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2.3e-35 522373003495 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1e-22 522373003496 2 probable transmembrane helices predicted for Smlt0884 by TMHMM2.0 at aa 20-42 and 285-307 522373003497 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 522373003498 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 522373003499 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373003500 HMMPfam hit to PF00593, TonB dependent receptor, score 6.7e-26 522373003501 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.7e-21 522373003502 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 522373003503 proposed catalytic triad [active] 522373003504 active site nucleophile [active] 522373003505 1 probable transmembrane helix predicted for Smlt0886 by TMHMM2.0 at aa 13-35 522373003506 HMMPfam hit to PF03575, Peptidase family S51, score 2.2e-06 522373003507 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 522373003508 catalytic nucleophile [active] 522373003509 HMMPfam hit to PF01112, Asparaginase, score 9.1e-98 522373003510 elongation factor Tu; Reviewed; Region: PRK00049 522373003511 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 522373003512 G1 box; other site 522373003513 GEF interaction site [polypeptide binding]; other site 522373003514 GTP/Mg2+ binding site [chemical binding]; other site 522373003515 Switch I region; other site 522373003516 G2 box; other site 522373003517 G3 box; other site 522373003518 Switch II region; other site 522373003519 G4 box; other site 522373003520 G5 box; other site 522373003521 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 522373003522 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 522373003523 Antibiotic Binding Site [chemical binding]; other site 522373003524 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2.2e-97 522373003525 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1e-27 522373003526 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 7.4e-60 522373003527 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 522373003528 3 probable transmembrane helices predicted for Smlt0891 by TMHMM2.0 at aa 21-38, 53-75 and 107-129 522373003529 HMMPfam hit to PF00584, SecE/Sec61-gamma subunits of protein translo, score 1.4e-15 522373003530 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 522373003531 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 522373003532 putative homodimer interface [polypeptide binding]; other site 522373003533 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 522373003534 heterodimer interface [polypeptide binding]; other site 522373003535 homodimer interface [polypeptide binding]; other site 522373003536 HMMPfam hit to PF02357, Transcription termination factor nusG, score 2.2e-50 522373003537 HMMPfam hit to PF00467, KOW motif, score 1e-10 522373003538 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 522373003539 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 522373003540 23S rRNA interface [nucleotide binding]; other site 522373003541 L7/L12 interface [polypeptide binding]; other site 522373003542 putative thiostrepton binding site; other site 522373003543 L25 interface [polypeptide binding]; other site 522373003544 HMMPfam hit to PF03946, Ribosomal protein L11, N-terminal dom, score 7.2e-35 522373003545 HMMPfam hit to PF00298, Ribosomal protein L11, RNA binding do, score 3.1e-33 522373003546 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 522373003547 mRNA/rRNA interface [nucleotide binding]; other site 522373003548 HMMPfam hit to PF00687, Ribosomal protein L1p/L10e family, score 2.3e-105 522373003549 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 522373003550 23S rRNA interface [nucleotide binding]; other site 522373003551 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 522373003552 HMMPfam hit to PF00466, Ribosomal protein L10, score 3.3e-22 522373003553 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 522373003554 core dimer interface [polypeptide binding]; other site 522373003555 peripheral dimer interface [polypeptide binding]; other site 522373003556 L10 interface [polypeptide binding]; other site 522373003557 L11 interface [polypeptide binding]; other site 522373003558 putative EF-Tu interaction site [polypeptide binding]; other site 522373003559 putative EF-G interaction site [polypeptide binding]; other site 522373003560 HMMPfam hit to PF00542, Ribosomal protein L7/L12 C-terminal dom, score 3.8e-31 522373003561 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 522373003562 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 522373003563 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 522373003564 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 522373003565 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 522373003566 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 522373003567 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 522373003568 RPB3 interaction site [polypeptide binding]; other site 522373003569 RPB1 interaction site [polypeptide binding]; other site 522373003570 RPB11 interaction site [polypeptide binding]; other site 522373003571 RPB10 interaction site [polypeptide binding]; other site 522373003572 HMMPfam hit to PF04563, RNA polymerase beta subunit, score 1e-39 522373003573 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain, score 7.1e-42 522373003574 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain, score 9.3e-180 522373003575 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain, score 2.6e-50 522373003576 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 522373003577 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 522373003578 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 522373003579 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 522373003580 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 522373003581 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 522373003582 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 522373003583 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 522373003584 DNA binding site [nucleotide binding] 522373003585 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 522373003586 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain, score 2.1e-155 522373003587 HMMPfam hit to PF00623, RNA polymerase Rpb1, domain, score 3.2e-85 522373003588 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain, score 3.5e-51 522373003589 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain, score 2.3e-30 522373003590 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain, score 4.9e-122 522373003591 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 522373003592 S17 interaction site [polypeptide binding]; other site 522373003593 S8 interaction site; other site 522373003594 16S rRNA interaction site [nucleotide binding]; other site 522373003595 streptomycin interaction site [chemical binding]; other site 522373003596 23S rRNA interaction site [nucleotide binding]; other site 522373003597 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 522373003598 HMMPfam hit to PF00164, Ribosomal protein S12, score 5.5e-71 522373003599 30S ribosomal protein S7; Validated; Region: PRK05302 522373003600 HMMPfam hit to PF00177, Ribosomal protein S7p/S5e, score 3.8e-75 522373003601 elongation factor G; Reviewed; Region: PRK00007 522373003602 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 522373003603 G1 box; other site 522373003604 putative GEF interaction site [polypeptide binding]; other site 522373003605 GTP/Mg2+ binding site [chemical binding]; other site 522373003606 Switch I region; other site 522373003607 G2 box; other site 522373003608 G3 box; other site 522373003609 Switch II region; other site 522373003610 G4 box; other site 522373003611 G5 box; other site 522373003612 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 522373003613 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 522373003614 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 522373003615 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 4.6e-112 522373003616 HMMPfam hit to PF03144, Elongation factor Tu domain, score 5.5e-20 522373003617 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 4.2e-60 522373003618 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 1.5e-48 522373003619 elongation factor Tu; Reviewed; Region: PRK00049 522373003620 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 522373003621 G1 box; other site 522373003622 GEF interaction site [polypeptide binding]; other site 522373003623 GTP/Mg2+ binding site [chemical binding]; other site 522373003624 Switch I region; other site 522373003625 G2 box; other site 522373003626 G3 box; other site 522373003627 Switch II region; other site 522373003628 G4 box; other site 522373003629 G5 box; other site 522373003630 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 522373003631 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 522373003632 Antibiotic Binding Site [chemical binding]; other site 522373003633 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2.2e-97 522373003634 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1e-27 522373003635 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 7.4e-60 522373003636 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 522373003637 HMMPfam hit to PF00338, Ribosomal protein S10p/S20e, score 1.1e-56 522373003638 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 522373003639 HMMPfam hit to PF00297, Ribosomal protein L3, score 6.1e-82 522373003640 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 522373003641 HMMPfam hit to PF00573, Ribosomal protein L4/L1 family, score 4.7e-44 522373003642 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 522373003643 HMMPfam hit to PF00276, Ribosomal protein L23, score 4.8e-27 522373003644 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 522373003645 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 522373003646 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 522373003647 HMMPfam hit to PF00181, Ribosomal Proteins L2, RNA binding dom, score 2.4e-45 522373003648 HMMPfam hit to PF03947, Ribosomal Proteins L2, C-terminal doma, score 1.5e-82 522373003649 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 522373003650 HMMPfam hit to PF00203, Ribosomal protein S19, score 4.9e-48 522373003651 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 522373003652 putative translocon binding site; other site 522373003653 protein-rRNA interface [nucleotide binding]; other site 522373003654 HMMPfam hit to PF00237, Ribosomal protein L22p/L17e, score 2.5e-49 522373003655 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 522373003656 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 522373003657 G-X-X-G motif; other site 522373003658 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 522373003659 HMMPfam hit to PF00417, Ribosomal protein S3, N-terminal domai, score 1.5e-24 522373003660 HMMPfam hit to PF07650, KH domain, score 2.3e-21 522373003661 HMMPfam hit to PF00189, Ribosomal protein S3, C-terminal domai, score 5.7e-49 522373003662 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 522373003663 23S rRNA interface [nucleotide binding]; other site 522373003664 5S rRNA interface [nucleotide binding]; other site 522373003665 putative antibiotic binding site [chemical binding]; other site 522373003666 L25 interface [polypeptide binding]; other site 522373003667 L27 interface [polypeptide binding]; other site 522373003668 HMMPfam hit to PF00252, Ribosomal protein L16, score 4.8e-83 522373003669 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 522373003670 putative translocon interaction site; other site 522373003671 23S rRNA interface [nucleotide binding]; other site 522373003672 signal recognition particle (SRP54) interaction site; other site 522373003673 L23 interface [polypeptide binding]; other site 522373003674 trigger factor interaction site; other site 522373003675 HMMPfam hit to PF00831, Ribosomal L29 protein, score 1.5e-23 522373003676 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 522373003677 HMMPfam hit to PF00366, Ribosomal protein S17, score 6.1e-36 522373003678 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 522373003679 HMMPfam hit to PF00238, Ribosomal protein L14p/L23e, score 4.6e-76 522373003680 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 522373003681 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 522373003682 RNA binding site [nucleotide binding]; other site 522373003683 HMMPfam hit to PF00467, KOW motif, score 1.9e-07 522373003684 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 522373003685 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 522373003686 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 522373003687 HMMPfam hit to PF00281, Ribosomal protein L5, score 1.7e-31 522373003688 HMMPfam hit to PF00673, ribosomal L5P family C-terminus, score 7.8e-55 522373003689 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 522373003690 HMMPfam hit to PF00253, Ribosomal protein S14p/S29e, score 1.1e-18 522373003691 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 522373003692 HMMPfam hit to PF00410, Ribosomal protein S8, score 6.7e-57 522373003693 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 522373003694 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 522373003695 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 522373003696 HMMPfam hit to PF00347, Ribosomal protein L6, score 4.7e-08 522373003697 HMMPfam hit to PF00347, Ribosomal protein L6, score 1.8e-30 522373003698 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 522373003699 5S rRNA interface [nucleotide binding]; other site 522373003700 23S rRNA interface [nucleotide binding]; other site 522373003701 L5 interface [polypeptide binding]; other site 522373003702 HMMPfam hit to PF00861, Ribosomal L18p/L5e family, score 5.8e-33 522373003703 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 522373003704 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 522373003705 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 522373003706 HMMPfam hit to PF00333, Ribosomal protein S5, N-terminal domai, score 3.8e-32 522373003707 HMMPfam hit to PF03719, Ribosomal protein S5, C-terminal domai, score 2.5e-31 522373003708 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 522373003709 23S rRNA binding site [nucleotide binding]; other site 522373003710 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 522373003711 HMMPfam hit to PF01305, Ribosomal protein L15 amino terminal re, score 1.5e-40 522373003712 HMMPfam hit to PF00256, Ribosomal protein L15, score 5.8e-08 522373003713 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 522373003714 SecY translocase; Region: SecY; pfam00344 522373003715 9 probable transmembrane helices predicted for Smlt0926 by TMHMM2.0 at aa 23-45, 77-99, 119-141, 156-178, 185-207, 217-239, 266-288, 322-344 and 403-425 522373003716 HMMPfam hit to PF00344, eubacterial secY protein, score 5.4e-160 522373003717 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 522373003718 30S ribosomal protein S13; Region: bact_S13; TIGR03631 522373003719 HMMPfam hit to PF00416, Ribosomal protein S13/S18, score 1.2e-52 522373003720 30S ribosomal protein S11; Validated; Region: PRK05309 522373003721 HMMPfam hit to PF00411, Ribosomal protein S11, score 4e-67 522373003722 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 522373003723 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 522373003724 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373003725 RNA binding surface [nucleotide binding]; other site 522373003726 HMMPfam hit to PF00163, Ribosomal protein S4/S9 N-terminal domai, score 3.5e-33 522373003727 HMMPfam hit to PF01479, S4 domain, score 3.1e-21 522373003728 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 522373003729 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 522373003730 alphaNTD homodimer interface [polypeptide binding]; other site 522373003731 alphaNTD - beta interaction site [polypeptide binding]; other site 522373003732 alphaNTD - beta' interaction site [polypeptide binding]; other site 522373003733 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 522373003734 HMMPfam hit to PF01193, RNA polymerase Rpb3/Rpb11 dimerisation, score 8e-28 522373003735 HMMPfam hit to PF01000, RNA polymerase Rpb3/RpoA insert domain, score 3.7e-57 522373003736 HMMPfam hit to PF03118, Bacterial RNA polymerase, alpha chain C, score 6.8e-29 522373003737 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 522373003738 HMMPfam hit to PF01196, Ribosomal protein L17, score 2.8e-57 522373003739 disulfide bond formation protein B; Provisional; Region: PRK04388 522373003740 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 3.3e-10 522373003741 4 probable transmembrane helices predicted for Smlt0935 by TMHMM2.0 at aa 12-31, 41-63, 70-92 and 142-164 522373003742 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373003743 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373003744 HMMPfam hit to PF00593, TonB dependent receptor, score 7.1e-20 522373003745 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 6.3e-13 522373003746 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 522373003747 HMMPfam hit to PF01474, Class-II DAHP synthetase family, score 1.9e-206 522373003748 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 522373003749 Mechanosensitive ion channel; Region: MS_channel; pfam00924 522373003750 5 probable transmembrane helices predicted for Smlt0939 by TMHMM2.0 at aa 12-34, 47-69, 84-103, 131-153 and 163-185 522373003751 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 4.1e-08 522373003752 amidase; Provisional; Region: PRK08137 522373003753 Amidase; Region: Amidase; cl11426 522373003754 HMMPfam hit to PF01425, Amidase, score 5.2e-102 522373003755 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 522373003756 3 probable transmembrane helices predicted for Smlt0941 by TMHMM2.0 at aa 76-98, 103-125 and 130-147 522373003757 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 522373003758 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 522373003759 G1 box; other site 522373003760 putative GEF interaction site [polypeptide binding]; other site 522373003761 GTP/Mg2+ binding site [chemical binding]; other site 522373003762 Switch I region; other site 522373003763 G2 box; other site 522373003764 G3 box; other site 522373003765 Switch II region; other site 522373003766 G4 box; other site 522373003767 G5 box; other site 522373003768 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 522373003769 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 522373003770 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 2.6e-24 522373003771 HMMPfam hit to PF03144, Elongation factor Tu domain, score 5.6e-15 522373003772 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2.3e-70 522373003773 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 522373003774 active site 522373003775 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 1.4e-57 522373003776 malate dehydrogenase; Provisional; Region: PRK05442 522373003777 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 522373003778 NAD(P) binding site [chemical binding]; other site 522373003779 dimer interface [polypeptide binding]; other site 522373003780 malate binding site [chemical binding]; other site 522373003781 HMMPfam hit to PF00056, lactate/malate dehydrogenase, NAD binding do, score 2.1e-55 522373003782 HMMPfam hit to PF02866, lactate/malate dehydrogenase, alpha/beta C-t, score 7.9e-37 522373003783 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 522373003784 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 522373003785 active site 522373003786 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3.5e-45 522373003787 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 522373003788 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 522373003789 acyl-activating enzyme (AAE) consensus motif; other site 522373003790 AMP binding site [chemical binding]; other site 522373003791 active site 522373003792 CoA binding site [chemical binding]; other site 522373003793 HMMPfam hit to PF00501, AMP-binding enzyme, score 3.3e-117 522373003794 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 522373003795 glutathionine S-transferase; Provisional; Region: PRK10542 522373003796 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 522373003797 C-terminal domain interface [polypeptide binding]; other site 522373003798 GSH binding site (G-site) [chemical binding]; other site 522373003799 dimer interface [polypeptide binding]; other site 522373003800 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 522373003801 dimer interface [polypeptide binding]; other site 522373003802 N-terminal domain interface [polypeptide binding]; other site 522373003803 substrate binding pocket (H-site) [chemical binding]; other site 522373003804 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 7.1e-10 522373003805 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 522373003806 HMMPfam hit to PF07486, Cell Wall Hydrolase, score 5.6e-42 522373003807 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 522373003808 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 522373003809 active site 522373003810 FMN binding site [chemical binding]; other site 522373003811 2,4-decadienoyl-CoA binding site; other site 522373003812 catalytic residue [active] 522373003813 4Fe-4S cluster binding site [ion binding]; other site 522373003814 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 522373003815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373003816 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoredu, score 0.00011 522373003817 HMMPfam hit to PF03486, HI0933-like protein, score 0.00066 522373003818 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 0.00028 522373003819 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 1.8e-100 522373003820 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 522373003821 Predicted membrane protein [Function unknown]; Region: COG2364 522373003822 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 522373003823 6 probable transmembrane helices predicted for Smlt0953 by TMHMM2.0 at aa 73-95, 110-132, 139-156, 166-188, 208-230 and 235-257 522373003824 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 7.4e-15 522373003825 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 7.5e-14 522373003826 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 522373003827 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 522373003828 putative NAD(P) binding site [chemical binding]; other site 522373003829 dimer interface [polypeptide binding]; other site 522373003830 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 6.1e-15 522373003831 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 5.2e-12 522373003832 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 522373003833 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 522373003834 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 522373003835 ligand binding site [chemical binding]; other site 522373003836 HMMPfam hit to PF00691, OmpA family, score 1.1e-32 522373003837 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 522373003838 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373003839 RNA binding surface [nucleotide binding]; other site 522373003840 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 522373003841 active site 522373003842 HMMPfam hit to PF01479, S4 domain, score 9.8e-06 522373003843 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 4.1e-11 522373003844 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 522373003845 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 522373003846 substrate-cofactor binding pocket; other site 522373003847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373003848 catalytic residue [active] 522373003849 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.3e-86 522373003850 HMMPfam hit to PF00202, Aminotransferase class-III, score 0.0019 522373003851 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 522373003852 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 522373003853 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 522373003854 NAD(P) binding site [chemical binding]; other site 522373003855 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.3e-41 522373003856 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 1.7e-52 522373003857 Peptidase S46; Region: Peptidase_S46; pfam10459 522373003858 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 522373003859 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 522373003860 catalytic core [active] 522373003861 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 4.4e-48 522373003862 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 522373003863 HMMPfam hit to PF08245, Mur ligase middle domain, score 3.2e-08 522373003864 Sporulation related domain; Region: SPOR; pfam05036 522373003865 Sporulation related domain; Region: SPOR; pfam05036 522373003866 1 probable transmembrane helix predicted for Smlt0965 by TMHMM2.0 at aa 9-27 522373003867 HMMPfam hit to PF05036, Sporulation related domain, score 1.6e-14 522373003868 HMMPfam hit to PF05036, Sporulation related domain, score 9.1e-20 522373003869 4 probable transmembrane helices predicted for Smlt0966 by TMHMM2.0 at aa 10-27, 32-51, 71-93 and 113-135 522373003870 Colicin V production protein; Region: Colicin_V; pfam02674 522373003871 HMMPfam hit to PF02674, Colicin V production protein, score 1.1e-34 522373003872 amidophosphoribosyltransferase; Provisional; Region: PRK09246 522373003873 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 522373003874 active site 522373003875 tetramer interface [polypeptide binding]; other site 522373003876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 522373003877 active site 522373003878 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 3.4e-41 522373003879 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 0.00027 522373003880 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 522373003881 dinuclear metal binding motif [ion binding]; other site 522373003882 HMMPfam hit to PF04305, Protein of unknown function (DUF455), score 9.9e-99 522373003883 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 522373003884 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 522373003885 1 probable transmembrane helix predicted for Smlt0970 by TMHMM2.0 at aa 20-42 522373003886 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 522373003887 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 522373003888 putative active site [active] 522373003889 putative metal binding site [ion binding]; other site 522373003890 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 5.3e-14 522373003891 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 522373003892 active site 522373003893 4 probable transmembrane helices predicted for Smlt0972 by TMHMM2.0 at aa 32-54, 64-81, 122-144 and 159-178 522373003894 HMMPfam hit to PF01569, PAP2 superfamily, score 3.2e-20 522373003895 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 522373003896 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 522373003897 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.1e-30 522373003898 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373003899 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373003900 HMMPfam hit to PF00593, TonB dependent receptor, score 1.3e-19 522373003901 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.5e-23 522373003902 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 522373003903 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 522373003904 HMMPfam hit to PF02541, Ppx/GppA phosphatase family, score 8.3e-65 522373003905 polyphosphate kinase; Provisional; Region: PRK05443 522373003906 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 522373003907 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 522373003908 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 522373003909 putative active site [active] 522373003910 catalytic site [active] 522373003911 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 522373003912 putative domain interface [polypeptide binding]; other site 522373003913 putative active site [active] 522373003914 catalytic site [active] 522373003915 HMMPfam hit to PF02503, Polyphosphate kinase, score 0 522373003916 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 522373003917 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 522373003918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373003919 dimer interface [polypeptide binding]; other site 522373003920 phosphorylation site [posttranslational modification] 522373003921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373003922 ATP binding site [chemical binding]; other site 522373003923 Mg2+ binding site [ion binding]; other site 522373003924 G-X-G motif; other site 522373003925 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.9e-39 522373003926 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.3e-21 522373003927 1 probable transmembrane helix predicted for Smlt0977 by TMHMM2.0 at aa 13-35 522373003928 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 522373003929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373003930 active site 522373003931 phosphorylation site [posttranslational modification] 522373003932 intermolecular recognition site; other site 522373003933 dimerization interface [polypeptide binding]; other site 522373003934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373003935 DNA binding site [nucleotide binding] 522373003936 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 3.3e-24 522373003937 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.3e-35 522373003938 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 522373003939 Peptidase family M48; Region: Peptidase_M48; pfam01435 522373003940 HMMPfam hit to PF01435, Peptidase family M48, score 6.6e-60 522373003941 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 522373003942 GSH binding site [chemical binding]; other site 522373003943 catalytic residues [active] 522373003944 HMMPfam hit to PF00462, Glutaredoxin, score 9.8e-22 522373003945 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 522373003946 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 1.9e-17 522373003947 isocitrate dehydrogenase; Provisional; Region: PRK08997 522373003948 tartrate dehydrogenase; Region: TTC; TIGR02089 522373003949 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 4.6e-134 522373003950 Isochorismatase family; Region: Isochorismatase; pfam00857 522373003951 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 522373003952 catalytic triad [active] 522373003953 conserved cis-peptide bond; other site 522373003954 HMMPfam hit to PF00857, Isochorismatase family, score 2.1e-09 522373003955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373003956 LysR family transcriptional regulator; Provisional; Region: PRK14997 522373003957 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373003958 putative effector binding pocket; other site 522373003959 dimerization interface [polypeptide binding]; other site 522373003960 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.6e-21 522373003961 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.8e-49 522373003962 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 522373003963 Bax inhibitor 1 like; Region: BaxI_1; cl17691 522373003964 HMMPfam hit to PF06539, Protein of unknown function (DUF1112), score 7.5e-119 522373003965 7 probable transmembrane helices predicted for Smlt0986 by TMHMM2.0 at aa 63-80, 90-112, 119-141, 146-165, 178-200, 210-229 and 250-272 522373003966 trigger factor; Provisional; Region: tig; PRK01490 522373003967 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 522373003968 HMMPfam hit to PF05697, Bacterial trigger factor protein (TF), score 2.5e-57 522373003969 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomera, score 0.019 522373003970 HMMPfam hit to PF05698, Bacterial trigger factor protein (TF) C-ter, score 2.6e-49 522373003971 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 522373003972 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 522373003973 oligomer interface [polypeptide binding]; other site 522373003974 active site residues [active] 522373003975 HMMPfam hit to PF00574, Clp protease, score 9.3e-136 522373003976 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 522373003977 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 522373003978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373003979 Walker A motif; other site 522373003980 ATP binding site [chemical binding]; other site 522373003981 Walker B motif; other site 522373003982 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 522373003983 HMMPfam hit to PF06689, ClpX C4-type zinc finger, score 9e-26 522373003984 HMMPfam hit to PF07724, ATPase family associated with various cell, score 1.1e-83 522373003985 HMMPfam hit to PF00004, ATPase family associated with various cell, score 1.1e-05 522373003986 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 522373003987 Found in ATP-dependent protease La (LON); Region: LON; smart00464 522373003988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373003989 Walker A motif; other site 522373003990 ATP binding site [chemical binding]; other site 522373003991 Walker B motif; other site 522373003992 arginine finger; other site 522373003993 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 522373003994 HMMPfam hit to PF02190, ATP-dependent protease La (LON) domain, score 9.7e-41 522373003995 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1e-42 522373003996 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 4.5e-05 522373003997 HMMPfam hit to PF05362, Lon protease (S16) C-terminal proteolytic do, score 6.7e-144 522373003998 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 522373003999 IHF dimer interface [polypeptide binding]; other site 522373004000 IHF - DNA interface [nucleotide binding]; other site 522373004001 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 7.4e-52 522373004002 periplasmic folding chaperone; Provisional; Region: PRK10788 522373004003 SurA N-terminal domain; Region: SurA_N_3; cl07813 522373004004 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 522373004005 1 probable transmembrane helix predicted for Smlt0993 by TMHMM2.0 at aa 12-29 522373004006 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 3.1e-34 522373004007 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 522373004008 N-acetyl-D-glucosamine binding site [chemical binding]; other site 522373004009 catalytic residue [active] 522373004010 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 522373004011 HMMPfam hit to PF01476, LysM domain, score 1.7e-13 522373004012 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.2e-22 522373004013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 522373004014 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 3.1e-31 522373004015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 522373004016 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 522373004017 RNA/DNA hybrid binding site [nucleotide binding]; other site 522373004018 active site 522373004019 HMMPfam hit to PF00075, RNase H, score 1.3e-58 522373004020 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 522373004021 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 522373004022 active site 522373004023 catalytic site [active] 522373004024 substrate binding site [chemical binding]; other site 522373004025 HMMPfam hit to PF00929, Exonuclease, score 2.1e-37 522373004026 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 522373004027 Protein phosphatase 2C; Region: PP2C; pfam00481 522373004028 active site 522373004029 HMMPfam hit to PF00481, Protein phosphatase 2C, score 5.6e-07 522373004030 Predicted periplasmic protein [Function unknown]; Region: COG3904 522373004031 Autotransporter beta-domain; Region: Autotransporter; smart00869 522373004032 HMMPfam hit to PF03797, Autotransporter beta-domain, score 3.2e-22 522373004033 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 522373004034 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 522373004035 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 522373004036 putative active site [active] 522373004037 HMMPfam hit to PF01075, Glycosyltransferase family, score 2.1e-87 522373004038 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 522373004039 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 522373004040 active site 522373004041 ATP binding site [chemical binding]; other site 522373004042 HMMPfam hit to PF06293, Lipopolysaccharide kinase (Kdo/WaaP) family, score 2.7e-94 522373004043 HMMPfam hit to PF01163, RIO1 family, score 2.6e-05 522373004044 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 522373004045 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 0.00025 522373004046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 522373004047 4 probable transmembrane helices predicted for Smlt1007 by TMHMM2.0 at aa 78-97, 107-126, 133-155 and 160-177 522373004048 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 522373004049 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 1.6e-42 522373004050 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 522373004051 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 522373004052 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 522373004053 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 522373004054 Autotransporter beta-domain; Region: Autotransporter; pfam03797 522373004055 HMMPfam hit to PF05594, Haemagluttinin repeat, score 3.7 522373004056 HMMPfam hit to PF05594, Haemagluttinin repeat, score 3.5 522373004057 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.05 522373004058 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.5 522373004059 HMMPfam hit to PF05594, Haemagluttinin repeat, score 3.2 522373004060 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.2 522373004061 HMMPfam hit to PF05594, Haemagluttinin repeat, score 4.1 522373004062 HMMPfam hit to PF05594, Haemagluttinin repeat, score 3.8 522373004063 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.46 522373004064 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.7 522373004065 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 46 522373004066 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 52 522373004067 HMMPfam hit to PF05594, Haemagluttinin repeat, score 3.2 522373004068 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 50 522373004069 HMMPfam hit to PF05594, Haemagluttinin repeat, score 4 522373004070 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.8e-17 522373004071 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.2e-10 522373004072 4 probable transmembrane helices predicted for Smlt1011 by TMHMM2.0 at aa 65-87, 100-122, 132-154 and 167-189 522373004073 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 522373004074 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 522373004075 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 2.5e-05 522373004076 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 522373004077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373004078 Walker A motif; other site 522373004079 ATP binding site [chemical binding]; other site 522373004080 Walker B motif; other site 522373004081 arginine finger; other site 522373004082 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 522373004083 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.5e-14 522373004084 hypothetical protein; Validated; Region: PRK00153 522373004085 HMMPfam hit to PF02575, Uncharacterised BCR, YbaB family COG0718, score 2.6e-49 522373004086 recombination protein RecR; Reviewed; Region: recR; PRK00076 522373004087 RecR protein; Region: RecR; pfam02132 522373004088 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 522373004089 putative active site [active] 522373004090 putative metal-binding site [ion binding]; other site 522373004091 tetramer interface [polypeptide binding]; other site 522373004092 HMMPfam hit to PF02132, RecR protein, score 4.2e-12 522373004093 HMMPfam hit to PF01751, Toprim domain, score 3.6e-14 522373004094 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 522373004095 nucleotide binding site/active site [active] 522373004096 HIT family signature motif; other site 522373004097 catalytic residue [active] 522373004098 HMMPfam hit to PF01230, HIT domain, score 1.6e-40 522373004099 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 522373004100 HMMPfam hit to PF03843, Outer membrane lipoprotein Slp family, score 1.8e-54 522373004101 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 522373004102 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 522373004103 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 522373004104 5 probable transmembrane helices predicted for Smlt1019 by TMHMM2.0 at aa 27-49, 61-78, 122-144, 165-184 and 541-563 522373004105 HMMPfam hit to PF01841, Transglutaminase-like superfamily, score 1.5e-21 522373004106 Protein of unknown function DUF58; Region: DUF58; pfam01882 522373004107 HMMPfam hit to PF01882, Protein of unknown function DUF58, score 8.3e-33 522373004108 2 probable transmembrane helices predicted for Smlt1020 by TMHMM2.0 at aa 34-56 and 61-83 522373004109 MoxR-like ATPases [General function prediction only]; Region: COG0714 522373004110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373004111 Walker A motif; other site 522373004112 ATP binding site [chemical binding]; other site 522373004113 Walker B motif; other site 522373004114 arginine finger; other site 522373004115 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 2.3e-07 522373004116 HMMPfam hit to PF07726, ATPase family associated with various cellul, score 5.9e-83 522373004117 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 522373004118 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 522373004119 9 probable transmembrane helices predicted for Smlt1022 by TMHMM2.0 at aa 9-31, 71-93, 100-122, 160-182, 194-211, 238-260, 273-295, 300-322 and 329-348 522373004120 Maf-like protein; Region: Maf; pfam02545 522373004121 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 522373004122 active site 522373004123 dimer interface [polypeptide binding]; other site 522373004124 HMMPfam hit to PF02545, Maf-like protein, score 3.2e-54 522373004125 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 522373004126 HMMPfam hit to PF02620, Uncharacterized ACR, COG1399, score 1.4e-45 522373004127 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 522373004128 HMMPfam hit to PF01783, Ribosomal L32p protein family, score 1.5e-19 522373004129 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 522373004130 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 522373004131 dimer interface [polypeptide binding]; other site 522373004132 active site 522373004133 CoA binding pocket [chemical binding]; other site 522373004134 HMMPfam hit to PF08545, 3-Oxoacyl-[acyl-carrier-protein (ACP)], score 9.1e-50 522373004135 HMMPfam hit to PF08541, 3-Oxoacyl-[acyl-carrier-protein (ACP)], score 5.5e-54 522373004136 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 522373004137 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 522373004138 HMMPfam hit to PF00698, Acyl transferase domain, score 1.7e-15 522373004139 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 522373004140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373004141 NAD(P) binding site [chemical binding]; other site 522373004142 active site 522373004143 HMMPfam hit to PF00106, short chain dehydrogenase, score 3e-40 522373004144 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.0022 522373004145 acyl carrier protein; Provisional; Region: acpP; PRK00982 522373004146 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.3e-22 522373004147 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 522373004148 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 522373004149 dimer interface [polypeptide binding]; other site 522373004150 active site 522373004151 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 7.2e-69 522373004152 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 2.5e-76 522373004153 hypothetical protein; Validated; Region: PRK09070 522373004154 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 522373004155 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 522373004156 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 3.4e-08 522373004157 HMMPfam hit to PF00425, chorismate binding enzyme, score 1.2e-119 522373004158 YceG-like family; Region: YceG; pfam02618 522373004159 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 522373004160 dimerization interface [polypeptide binding]; other site 522373004161 1 probable transmembrane helix predicted for Smlt1034 by TMHMM2.0 at aa 2-21 522373004162 HMMPfam hit to PF02618, Aminodeoxychorismate lyase, score 6e-144 522373004163 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 522373004164 thymidylate kinase; Region: DTMP_kinase; TIGR00041 522373004165 TMP-binding site; other site 522373004166 ATP-binding site [chemical binding]; other site 522373004167 HMMPfam hit to PF02223, Thymidylate kinase, score 2.7e-59 522373004168 DNA polymerase III subunit delta'; Validated; Region: PRK08769 522373004169 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 522373004170 DNA polymerase III subunit delta'; Validated; Region: PRK08485 522373004171 PilZ domain; Region: PilZ; cl01260 522373004172 HMMPfam hit to PF07238, PilZ domain, score 5.3e-06 522373004173 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 522373004174 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 522373004175 dimer interface [polypeptide binding]; other site 522373004176 hexamer interface [polypeptide binding]; other site 522373004177 active site 2 [active] 522373004178 HMMPfam hit to PF01361, Tautomerase enzyme, score 0.0074 522373004179 HMMPfam hit to PF01361, Tautomerase enzyme, score 1.4e-08 522373004180 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 522373004181 HMMPfam hit to PF05954, Phage late control gene D protein (GPD), score 4.7e-121 522373004182 Phage Tail Protein X; Region: Phage_tail_X; cl02088 522373004183 HMMPfam hit to PF05489, Phage Tail Protein X, score 3.1e-18 522373004184 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 522373004185 HMMPfam hit to PF06995, Phage P2 GpU, score 2.9e-38 522373004186 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 522373004187 2 probable transmembrane helices predicted for Smlt1042 by TMHMM2.0 at aa 507-529 and 621-643 522373004188 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 522373004189 Phage tail tube protein FII; Region: Phage_tube; pfam04985 522373004190 HMMPfam hit to PF04985, Phage tail tube protein FII, score 3.5e-32 522373004191 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 522373004192 HMMPfam hit to PF04984, Phage tail sheath protein, score 1.5e-127 522373004193 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 522373004194 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 522373004195 Baseplate J-like protein; Region: Baseplate_J; cl01294 522373004196 HMMPfam hit to PF04865, Baseplate J-like protein, score 1.2e-82 522373004197 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 522373004198 HMMPfam hit to PF04965, GPW / gp25 family, score 1.3e-38 522373004199 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 522373004200 HMMPfam hit to PF04717, Phage-related baseplate assembly protein, score 9e-35 522373004201 1 probable transmembrane helix predicted for Smlt1053 by TMHMM2.0 at aa 5-27 522373004202 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 522373004203 catalytic residue [active] 522373004204 HMMPfam hit to PF00959, Phage lysozyme, score 1.1e-14 522373004205 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 522373004206 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 522373004207 DNA-binding interface [nucleotide binding]; DNA binding site 522373004208 deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575 522373004209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 522373004210 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 522373004211 active site 522373004212 metal binding site [ion binding]; metal-binding site 522373004213 interdomain interaction site; other site 522373004214 Virulence-associated protein E; Region: VirE; pfam05272 522373004215 HMMPfam hit to PF05272, Virulence-associated protein E, score 1.6e-21 522373004216 2 probable transmembrane helices predicted for Smlt1066 by TMHMM2.0 at aa 13-32 and 93-115 522373004217 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 522373004218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373004219 N-terminal plug; other site 522373004220 ligand-binding site [chemical binding]; other site 522373004221 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.2e-18 522373004222 HMMPfam hit to PF00593, TonB dependent receptor, score 2.1e-20 522373004223 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 522373004224 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 522373004225 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.57 522373004226 4 probable transmembrane helices predicted for Smlt1068 by TMHMM2.0 at aa 13-35, 210-232, 252-274 and 467-489 522373004227 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.07 522373004228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373004229 putative substrate translocation pore; other site 522373004230 12 probable transmembrane helices predicted for Smlt1069 by TMHMM2.0 at aa 20-37, 47-69, 78-100, 104-126, 138-160, 164-186, 199-221, 236-258, 270-292, 296-318, 325-347 and 351-373 522373004231 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.7e-23 522373004232 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 522373004233 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 522373004234 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 522373004235 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 2.5e-19 522373004236 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 3.1e-15 522373004237 HMMPfam hit to PF08279, HTH domain, score 0.00053 522373004238 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 522373004239 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 522373004240 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 522373004241 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 522373004242 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 0.0008 522373004243 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 0.25 522373004244 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 3.4e-06 522373004245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 522373004246 HMMPfam hit to PF08241, Methyltransferase domain, score 8e-14 522373004247 HMMPfam hit to PF08242, Methyltransferase domain, score 2.8e-16 522373004248 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 522373004249 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 522373004250 C-terminal domain interface [polypeptide binding]; other site 522373004251 GSH binding site (G-site) [chemical binding]; other site 522373004252 dimer interface [polypeptide binding]; other site 522373004253 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 522373004254 N-terminal domain interface [polypeptide binding]; other site 522373004255 dimer interface [polypeptide binding]; other site 522373004256 substrate binding pocket (H-site) [chemical binding]; other site 522373004257 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 0.00019 522373004258 LysR family transcriptional regulator; Provisional; Region: PRK14997 522373004259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373004260 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373004261 putative effector binding pocket; other site 522373004262 dimerization interface [polypeptide binding]; other site 522373004263 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-42 522373004264 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 522373004265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373004266 DNA-binding site [nucleotide binding]; DNA binding site 522373004267 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373004268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373004269 homodimer interface [polypeptide binding]; other site 522373004270 catalytic residue [active] 522373004271 HMMPfam hit to PF00155, Aminotransferase class I and II, score 6.1e-15 522373004272 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fam, score 5.3e-15 522373004273 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 522373004274 10 probable transmembrane helices predicted for Smlt1076 by TMHMM2.0 at aa 25-47, 52-74, 87-106, 111-133, 140-157, 167-184, 197-216, 226-248, 255-277 and 282-304 522373004275 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 6.9e-11 522373004276 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 8.8e-16 522373004277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373004278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373004279 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 522373004280 putative effector binding pocket; other site 522373004281 putative dimerization interface [polypeptide binding]; other site 522373004282 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-48 522373004283 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.7e-19 522373004284 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 522373004285 14 probable transmembrane helices predicted for Smlt1078 by TMHMM2.0 at aa 12-34, 49-71, 80-102, 112-129, 136-158, 162-184, 197-219, 229-246, 266-288, 298-320, 327-346, 361-383, 396-418 and 466-488 522373004286 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.6e-45 522373004287 Uncharacterized conserved protein [Function unknown]; Region: COG3791 522373004288 HMMPfam hit to PF04828, Protein of unknown function (DUF636), score 1.3e-21 522373004289 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 522373004290 3 probable transmembrane helices predicted for Smlt1081 by TMHMM2.0 at aa 13-35, 39-61 and 73-90 522373004291 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 522373004292 1 probable transmembrane helix predicted for Smlt1082 by TMHMM2.0 at aa 12-33 522373004293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373004294 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373004295 14 probable transmembrane helices predicted for Smlt1083 by TMHMM2.0 at aa 45-67, 77-99, 108-127, 132-154, 167-189, 193-212, 233-252, 257-279, 292-314, 324-342, 355-377, 387-409, 421-443 and 448-470 522373004296 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.2e-40 522373004297 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 522373004298 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 522373004299 DNA binding residues [nucleotide binding] 522373004300 dimer interface [polypeptide binding]; other site 522373004301 [2Fe-2S] cluster binding site [ion binding]; other site 522373004302 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.9e-11 522373004303 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 522373004304 putative NAD(P) binding site [chemical binding]; other site 522373004305 homodimer interface [polypeptide binding]; other site 522373004306 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.8e-07 522373004307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373004308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373004309 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 522373004310 putative effector binding pocket; other site 522373004311 putative dimerization interface [polypeptide binding]; other site 522373004312 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.6e-15 522373004313 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.9e-46 522373004314 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 522373004315 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 522373004316 HMMPfam hit to PF03807, NADP oxidoreductase coenzyme F420-depen, score 2.6e-66 522373004317 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 522373004318 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 522373004319 catalytic residue [active] 522373004320 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 3.9e-25 522373004321 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 522373004322 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 522373004323 Walker A motif; other site 522373004324 ATP binding site [chemical binding]; other site 522373004325 Walker B motif; other site 522373004326 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 4e-34 522373004327 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 522373004328 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 522373004329 Walker A motif; other site 522373004330 ATP binding site [chemical binding]; other site 522373004331 Walker B motif; other site 522373004332 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 6.6e-12 522373004333 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 522373004334 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 522373004335 active site 522373004336 catalytic tetrad [active] 522373004337 HMMPfam hit to PF00248, Aldo/keto reductase family, score 2.3e-69 522373004338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373004339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373004340 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 522373004341 putative effector binding pocket; other site 522373004342 putative dimerization interface [polypeptide binding]; other site 522373004343 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.3e-42 522373004344 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.6e-24 522373004345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373004346 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373004347 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373004348 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 4.3e-27 522373004349 HMMPfam hit to PF01548, Transposase, score 1.8e-06 522373004350 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 522373004351 Uncharacterized conserved protein [Function unknown]; Region: COG1284 522373004352 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 522373004353 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 5.1e-17 522373004354 6 probable transmembrane helices predicted for Smlt1095 by TMHMM2.0 at aa 73-95, 100-122, 129-151, 155-177, 198-220 and 225-242 522373004355 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 9e-19 522373004356 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 522373004357 HMMPfam hit to PF03352, Methyladenine glycosylase, score 8.8e-30 522373004358 9 probable transmembrane helices predicted for Smlt1097 by TMHMM2.0 at aa 72-94, 101-123, 133-155, 176-197, 212-234, 247-269, 284-303, 315-337 and 352-374 522373004359 hypothetical protein; Validated; Region: PRK00228 522373004360 HMMPfam hit to PF02622, Uncharacterized ACR, COG1678, score 1.2e-92 522373004361 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 522373004362 HMMPfam hit to PF03652, Uncharacterised protein family (UPF0081), score 7.5e-56 522373004363 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 522373004364 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 522373004365 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 522373004366 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 8.4e-41 522373004367 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 2.9e-28 522373004368 Transposase IS200 like; Region: Y1_Tnp; pfam01797 522373004369 HMMPfam hit to PF07605, Protein of unknown function (DUF1568), score 9.6e-11 522373004370 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373004371 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 522373004372 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 522373004373 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 522373004374 Divalent cation transporter; Region: MgtE; pfam01769 522373004375 5 probable transmembrane helices predicted for Smlt1103 by TMHMM2.0 at aa 291-310, 320-342, 363-385, 390-412 and 425-447 522373004376 HMMPfam hit to PF01769, Divalent cation transporter score 1.9e-17 522373004377 HMMPfam hit to PF00571, CBS domain pair, score 2.2e-10 522373004378 HMMPfam hit to PF03448, MgtE intracellular domain, score 1.1e-47 522373004379 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 522373004380 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 522373004381 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 522373004382 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 522373004383 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 1.3e-115 522373004384 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 2.6e-19 522373004385 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 1.4e-44 522373004386 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 522373004387 dimerization domain swap beta strand [polypeptide binding]; other site 522373004388 regulatory protein interface [polypeptide binding]; other site 522373004389 active site 522373004390 regulatory phosphorylation site [posttranslational modification]; other site 522373004391 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 1.8e-30 522373004392 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 522373004393 active pocket/dimerization site; other site 522373004394 active site 522373004395 phosphorylation site [posttranslational modification] 522373004396 HMMPfam hit to PF03610, PTS system fructose IIA component, score 2.1e-05 522373004397 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 522373004398 AAA domain; Region: AAA_33; pfam13671 522373004399 HMMPfam hit to PF03668, P-loop ATPase family, score 8.9e-104 522373004400 HPr kinase/phosphorylase; Provisional; Region: PRK05428 522373004401 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 522373004402 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 522373004403 Hpr binding site; other site 522373004404 active site 522373004405 homohexamer subunit interaction site [polypeptide binding]; other site 522373004406 HMMPfam hit to PF07475, HPr Serine kinase C-terminus, score 3.3e-44 522373004407 HMMPfam hit to PF02603, HPr Serine kinase N terminus, score 0.00022 522373004408 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 522373004409 active site 522373004410 phosphorylation site [posttranslational modification] 522373004411 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 2.3e-18 522373004412 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 522373004413 30S subunit binding site; other site 522373004414 HMMPfam hit to PF02482, Sigma 54 modulation protein / S30EA r, score 6e-31 522373004415 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 522373004416 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 522373004417 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 522373004418 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 522373004419 HMMPfam hit to PF04552, Sigma-54, DNA binding domain, score 1.4e-95 522373004420 HMMPfam hit to PF04963, Sigma-54 factor, core binding domain, score 1.5e-54 522373004421 HMMPfam hit to PF00309, Sigma-54 factor, Activator interacting do, score 8.4e-21 522373004422 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 522373004423 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 522373004424 Walker A/P-loop; other site 522373004425 ATP binding site [chemical binding]; other site 522373004426 Q-loop/lid; other site 522373004427 ABC transporter signature motif; other site 522373004428 Walker B; other site 522373004429 D-loop; other site 522373004430 H-loop/switch region; other site 522373004431 HMMPfam hit to PF00005, ABC transporter score 1.6e-60 522373004432 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 522373004433 OstA-like protein; Region: OstA; pfam03968 522373004434 HMMPfam hit to PF03968, OstA-like protein, score 1.7e-21 522373004435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 522373004436 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 522373004437 HMMPfam hit to PF06835, Protein of unknown function (DUF1239), score 5.2e-43 522373004438 1 probable transmembrane helix predicted for Smlt1115 by TMHMM2.0 at aa 5-27 522373004439 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 522373004440 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 522373004441 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 522373004442 putative active site [active] 522373004443 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 522373004444 HMMPfam hit to PF00571, CBS domain pair, score 3.1e-30 522373004445 HMMPfam hit to PF01380, SIS domain, score 1.4e-34 522373004446 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 522373004447 HMMPfam hit to PF01722, BolA-like protein, score 7.2e-11 522373004448 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 522373004449 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 522373004450 hinge; other site 522373004451 active site 522373004452 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 2.6e-151 522373004453 1 probable transmembrane helix predicted for Smlt1120 by TMHMM2.0 at aa 13-35 522373004454 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 522373004455 1 probable transmembrane helix predicted for Smlt1121 by TMHMM2.0 at aa 7-26 522373004456 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 522373004457 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 522373004458 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 522373004459 active site 522373004460 substrate binding site [chemical binding]; other site 522373004461 cosubstrate binding site; other site 522373004462 catalytic site [active] 522373004463 HMMPfam hit to PF00551, Formyl transferase, score 5.4e-58 522373004464 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 522373004465 5 probable transmembrane helices predicted for Smlt1124 by TMHMM2.0 at aa 23-40, 45-62, 69-91, 123-140 and 153-175 522373004466 3 probable transmembrane helices predicted for Smlt1125 by TMHMM2.0 at aa 39-61, 85-107 and 119-141 522373004467 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 522373004468 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 522373004469 dimerization interface [polypeptide binding]; other site 522373004470 putative ATP binding site [chemical binding]; other site 522373004471 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 4.2e-51 522373004472 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 1.5e-70 522373004473 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 522373004474 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 522373004475 Domain of unknown function DUF20; Region: UPF0118; pfam01594 522373004476 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 7.4e-52 522373004477 7 probable transmembrane helices predicted for Smlt1128 by TMHMM2.0 at aa 20-49, 64-86, 157-179, 222-244, 251-273, 283-302 and 315-337 522373004478 hypothetical protein; Validated; Region: PRK08727 522373004479 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 522373004480 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 522373004481 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 522373004482 Substrate binding site; other site 522373004483 metal-binding site 522373004484 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.1e-10 522373004485 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 522373004486 Phosphotransferase enzyme family; Region: APH; pfam01636 522373004487 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 7.8e-20 522373004488 Predicted membrane protein [Function unknown]; Region: COG2261 522373004489 3 probable transmembrane helices predicted for Smlt1132 by TMHMM2.0 at aa 15-33, 40-62 and 72-91 522373004490 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 522373004491 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 522373004492 metal binding site [ion binding]; metal-binding site 522373004493 putative dimer interface [polypeptide binding]; other site 522373004494 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 6.7e-25 522373004495 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 5.9e-13 522373004496 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 522373004497 hypothetical protein; Provisional; Region: PRK06132 522373004498 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 522373004499 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 9.2e-21 522373004500 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 522373004501 HutD; Region: HutD; pfam05962 522373004502 HMMPfam hit to PF05962, Bacterial protein of unknown function (DUF88, score 1.2e-60 522373004503 Flavodoxin; Region: Flavodoxin_1; pfam00258 522373004504 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 522373004505 FAD binding pocket [chemical binding]; other site 522373004506 FAD binding motif [chemical binding]; other site 522373004507 catalytic residues [active] 522373004508 NAD binding pocket [chemical binding]; other site 522373004509 phosphate binding motif [ion binding]; other site 522373004510 beta-alpha-beta structure motif; other site 522373004511 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 2.4e-07 522373004512 HMMPfam hit to PF00258, Flavodoxin, score 1e-25 522373004513 2 probable transmembrane helices predicted for Smlt1138 by TMHMM2.0 at aa 10-32 and 45-64 522373004514 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 522373004515 ApbE family; Region: ApbE; pfam02424 522373004516 HMMPfam hit to PF02424, ApbE family, score 1.8e-64 522373004517 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 522373004518 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 522373004519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 522373004520 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 522373004521 3 probable transmembrane helices predicted for Smlt1142 by TMHMM2.0 at aa 17-39, 152-174 and 186-203 522373004522 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.00019 522373004523 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.028 522373004524 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 522373004525 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373004526 N-terminal plug; other site 522373004527 ligand-binding site [chemical binding]; other site 522373004528 HMMPfam hit to PF00593, TonB dependent receptor, score 6.1e-25 522373004529 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.3e-26 522373004530 1 probable transmembrane helix predicted for Smlt1145 by TMHMM2.0 at aa 25-47 522373004531 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 522373004532 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 6.2e-09 522373004533 Sel1 repeat; Region: Sel1; cl02723 522373004534 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 522373004535 Sel1-like repeats; Region: SEL1; smart00671 522373004536 Sel1-like repeats; Region: SEL1; smart00671 522373004537 Sel1-like repeats; Region: SEL1; smart00671 522373004538 HMMPfam hit to PF08238, Sel1 repeat, score 0.69 522373004539 HMMPfam hit to PF08238, Sel1 repeat, score 2e-07 522373004540 HMMPfam hit to PF08238, Sel1 repeat, score 1e-06 522373004541 HMMPfam hit to PF08238, Sel1 repeat, score 1.9e-08 522373004542 HMMPfam hit to PF08238, Sel1 repeat, score 5.6e-07 522373004543 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 522373004544 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373004545 N-terminal plug; other site 522373004546 ligand-binding site [chemical binding]; other site 522373004547 HMMPfam hit to PF00593, TonB dependent receptor, score 4.3e-31 522373004548 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.4e-22 522373004549 1 probable transmembrane helix predicted for Smlt1149 by TMHMM2.0 at aa 13-35 522373004550 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 522373004551 [2Fe-2S] cluster binding site [ion binding]; other site 522373004552 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain, score 4.6e-18 522373004553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 522373004554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373004555 Coenzyme A binding pocket [chemical binding]; other site 522373004556 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.2e-16 522373004557 Transposase IS200 like; Region: Y1_Tnp; pfam01797 522373004558 HMMPfam hit to PF07605, Protein of unknown function (DUF1568), score 1.9e-17 522373004559 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 522373004560 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 522373004561 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373004562 catalytic residue [active] 522373004563 HMMPfam hit to PF00266, Aminotransferase class-V, score 8e-208 522373004564 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.0032 522373004565 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 522373004566 FeS assembly protein SufD; Region: sufD; TIGR01981 522373004567 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 3e-44 522373004568 FeS assembly ATPase SufC; Region: sufC; TIGR01978 522373004569 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 522373004570 Walker A/P-loop; other site 522373004571 ATP binding site [chemical binding]; other site 522373004572 Q-loop/lid; other site 522373004573 ABC transporter signature motif; other site 522373004574 Walker B; other site 522373004575 D-loop; other site 522373004576 H-loop/switch region; other site 522373004577 HMMPfam hit to PF00005, ABC transporter score 6.5e-30 522373004578 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 522373004579 putative ABC transporter; Region: ycf24; CHL00085 522373004580 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 1.4e-131 522373004581 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 522373004582 Transcriptional regulator; Region: Rrf2; pfam02082 522373004583 Transcriptional regulator; Region: Rrf2; cl17282 522373004584 HMMPfam hit to PF02082, Transcriptional regulator, score 1.9e-39 522373004585 HMMPfam hit to PF01047, MarR family, score 0.0014 522373004586 Proteins containing SET domain [General function prediction only]; Region: COG2940 522373004587 SET domain; Region: SET; pfam00856 522373004588 HMMPfam hit to PF00856, SET domain, score 2.1e-27 522373004589 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 522373004590 intracellular protease, PfpI family; Region: PfpI; TIGR01382 522373004591 proposed catalytic triad [active] 522373004592 conserved cys residue [active] 522373004593 HMMPfam hit to PF01965, DJ-1/PfpI family, score 2.6e-46 522373004594 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 522373004595 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 522373004596 IHF dimer interface [polypeptide binding]; other site 522373004597 IHF - DNA interface [nucleotide binding]; other site 522373004598 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 1.3e-13 522373004599 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 522373004600 HMMPfam hit to PF02566, OsmC-like protein, score 1e-28 522373004601 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 522373004602 HMMPfam hit to PF02567, Phenazine biosynthesis-like protein, score 1.1e-48 522373004603 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 522373004604 HMMPfam hit to PF02567, Phenazine biosynthesis-like protein, score 2.2e-30 522373004605 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 522373004606 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 522373004607 nucleotide binding site [chemical binding]; other site 522373004608 substrate binding site [chemical binding]; other site 522373004609 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 522373004610 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 522373004611 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 522373004612 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 522373004613 catalytic residue [active] 522373004614 HMMPfam hit to PF00696, Amino acid kinase family, score 1.6e-35 522373004615 HMMPfam hit to PF01842, ACT domain, score 0.0031 522373004616 HMMPfam hit to PF01842, ACT domain, score 1 522373004617 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 6.7e-44 522373004618 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 2.7e-33 522373004619 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 522373004620 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 522373004621 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 522373004622 HMMPfam hit to PF08245, Mur ligase middle domain, score 2.6e-52 522373004623 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 1.1e-05 522373004624 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 522373004625 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 522373004626 1 probable transmembrane helix predicted for Smlt1172 by TMHMM2.0 at aa 26-45 522373004627 HMMPfam hit to PF01738, Dienelactone hydrolase family, score 3.3e-35 522373004628 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 522373004629 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 522373004630 substrate binding pocket [chemical binding]; other site 522373004631 chain length determination region; other site 522373004632 substrate-Mg2+ binding site; other site 522373004633 catalytic residues [active] 522373004634 aspartate-rich region 1; other site 522373004635 active site lid residues [active] 522373004636 aspartate-rich region 2; other site 522373004637 HMMPfam hit to PF00348, Polyprenyl synthetase, score 3.5e-84 522373004638 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 522373004639 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 522373004640 active site 522373004641 catalytic site [active] 522373004642 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 522373004643 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 1e-87 522373004644 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 522373004645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373004646 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373004647 HMMPfam hit to PF00593, TonB dependent receptor, score 3.8e-19 522373004648 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.9e-18 522373004649 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 522373004650 1 probable transmembrane helix predicted for Smlt1177 by TMHMM2.0 at aa 21-43 522373004651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373004652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373004653 13 probable transmembrane helices predicted for Smlt1178 by TMHMM2.0 at aa 12-29, 49-71, 84-106, 148-170, 183-202, 235-254, 261-283, 309-331, 344-366, 376-395, 402-424, 439-461 and 468-490 522373004654 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3e-18 522373004655 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 522373004656 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 522373004657 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 522373004658 active site 522373004659 catalytic site [active] 522373004660 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 7.8e-48 522373004661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 522373004662 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.1e-14 522373004663 3 probable transmembrane helices predicted for Smlt1182 by TMHMM2.0 at aa 13-30, 34-56 and 69-91 522373004664 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 522373004665 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 522373004666 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 522373004667 Zn binding site [ion binding]; other site 522373004668 13 probable transmembrane helices predicted for Smlt1184 by TMHMM2.0 at aa 17-39, 54-76, 106-128, 148-170, 175-197, 239-261, 322-344, 359-381, 413-435, 445-467, 474-496, 525-547 and 567-589 522373004669 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 522373004670 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 522373004671 Walker A/P-loop; other site 522373004672 ATP binding site [chemical binding]; other site 522373004673 Q-loop/lid; other site 522373004674 ABC transporter signature motif; other site 522373004675 Walker B; other site 522373004676 D-loop; other site 522373004677 H-loop/switch region; other site 522373004678 HMMPfam hit to PF00005, ABC transporter score 8.7e-45 522373004679 Transcriptional regulators [Transcription]; Region: PurR; COG1609 522373004680 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 522373004681 DNA binding site [nucleotide binding] 522373004682 domain linker motif; other site 522373004683 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 522373004684 putative dimerization interface [polypeptide binding]; other site 522373004685 putative ligand binding site [chemical binding]; other site 522373004686 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.1e-09 522373004687 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 8.5e-05 522373004688 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 522373004689 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 522373004690 dimer interface [polypeptide binding]; other site 522373004691 ssDNA binding site [nucleotide binding]; other site 522373004692 tetramer (dimer of dimers) interface [polypeptide binding]; other site 522373004693 HMMPfam hit to PF00436, Single-strand binding protein family, score 5.8e-22 522373004694 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 522373004695 1 probable transmembrane helix predicted for Smlt1188 by TMHMM2.0 at aa 20-42 522373004696 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 2.4e-23 522373004697 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 522373004698 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 522373004699 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 522373004700 HMMPfam hit to PF00732, GMC oxidoreductase, score 2.2e-05 522373004701 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 522373004702 1 probable transmembrane helix predicted for Smlt1190 by TMHMM2.0 at aa 150-172 522373004703 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 522373004704 HMMPfam hit to PF06439, Domain of Unknown Function (DUF1080), score 8.7e-34 522373004705 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 522373004706 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 522373004707 HMMPfam hit to PF00034, Cytochrome c, score 5e-06 522373004708 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 522373004709 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 1.9e-25 522373004710 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 522373004711 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 522373004712 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 522373004713 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 0.00052 522373004714 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 3.3e-38 522373004715 HMMPfam hit to PF03447, Homoserine dehydrogenase, NAD binding, score 0.0015 522373004716 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 522373004717 HMMPfam hit to PF03825, Nucleoside H+ symporter, score 4.4e-119 522373004718 12 probable transmembrane helices predicted for Smlt1195 by TMHMM2.0 at aa 13-32, 42-64, 73-92, 96-118, 131-153, 163-180, 210-232, 245-267, 274-291, 295-317, 338-360 and 370-392 522373004719 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.4e-10 522373004720 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 522373004721 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 522373004722 Metal-binding active site; metal-binding site 522373004723 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 522373004724 HMMPfam hit to PF07582, AP endonuclease family 2 C terminus, score 4.3e-31 522373004725 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 4.9e-35 522373004726 Transcriptional regulators [Transcription]; Region: PurR; COG1609 522373004727 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 522373004728 DNA binding site [nucleotide binding] 522373004729 domain linker motif; other site 522373004730 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 522373004731 dimerization interface [polypeptide binding]; other site 522373004732 ligand binding site [chemical binding]; other site 522373004733 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.6e-08 522373004734 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 3.9e-24 522373004735 MASE2 domain; Region: MASE2; pfam05230 522373004736 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373004737 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373004738 metal binding site [ion binding]; metal-binding site 522373004739 active site 522373004740 I-site; other site 522373004741 4 probable transmembrane helices predicted for Smlt1198 by TMHMM2.0 at aa 73-95, 115-137, 149-171 and 181-203 522373004742 HMMPfam hit to PF00990, GGDEF domain, score 3.5e-57 522373004743 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 522373004744 6 probable transmembrane helices predicted for Smlt1199 by TMHMM2.0 at aa 23-45, 65-87, 209-228, 238-255, 260-282 and 309-331 522373004745 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373004746 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373004747 metal binding site [ion binding]; metal-binding site 522373004748 active site 522373004749 I-site; other site 522373004750 2 probable transmembrane helices predicted for Smlt1200 by TMHMM2.0 at aa 20-42 and 338-360 522373004751 HMMPfam hit to PF00672, HAMP domain, score 0.00029 522373004752 HMMPfam hit to PF00990, GGDEF domain, score 1.4e-52 522373004753 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 522373004754 CoenzymeA binding site [chemical binding]; other site 522373004755 subunit interaction site [polypeptide binding]; other site 522373004756 PHB binding site; other site 522373004757 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.6e-07 522373004758 4 probable transmembrane helices predicted for Smlt1202 by TMHMM2.0 at aa 47-69, 103-125, 130-152 and 165-187 522373004759 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 522373004760 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 522373004761 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 522373004762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373004763 dimerization interface [polypeptide binding]; other site 522373004764 putative DNA binding site [nucleotide binding]; other site 522373004765 putative Zn2+ binding site [ion binding]; other site 522373004766 HMMPfam hit to PF08279, HTH domain, score 0.002 522373004767 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 3.9e-14 522373004768 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 522373004769 4 probable transmembrane helices predicted for Smlt1207 by TMHMM2.0 at aa 69-91, 114-136, 163-185 and 195-217 522373004770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373004771 non-specific DNA binding site [nucleotide binding]; other site 522373004772 salt bridge; other site 522373004773 sequence-specific DNA binding site [nucleotide binding]; other site 522373004774 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 522373004775 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 522373004776 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 522373004777 Transporter associated domain; Region: CorC_HlyC; smart01091 522373004778 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 4e-40 522373004779 7 probable transmembrane helices predicted for Smlt1209 by TMHMM2.0 at aa 13-35, 48-68, 83-100, 121-140, 155-172, 185-207 and 212-231 522373004780 HMMPfam hit to PF00571, CBS domain pair, score 5.1e-19 522373004781 HMMPfam hit to PF03471, Transporter associated domain, score 3.1e-24 522373004782 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 522373004783 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 522373004784 putative active site [active] 522373004785 putative metal binding site [ion binding]; other site 522373004786 3 probable transmembrane helices predicted for Smlt1210 by TMHMM2.0 at aa 2-24, 28-50 and 63-85 522373004787 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.7e-15 522373004788 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 522373004789 7 probable transmembrane helices predicted for Smlt1211 by TMHMM2.0 at aa 20-42, 49-71, 86-108, 120-142, 157-176, 188-205 and 209-231 522373004790 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 522373004791 hypothetical protein; Provisional; Region: PRK05409 522373004792 HMMPfam hit to PF05114, Protein of unknown function (DUF692), score 1e-161 522373004793 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 0.0029 522373004794 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 522373004795 EF-hand domain pair; Region: EF_hand_5; pfam13499 522373004796 Ca2+ binding site [ion binding]; other site 522373004797 1 probable transmembrane helix predicted for Smlt1214 by TMHMM2.0 at aa 21-43 522373004798 Predicted membrane protein [Function unknown]; Region: COG2259 522373004799 5 probable transmembrane helices predicted for Smlt1215 by TMHMM2.0 at aa 64-86, 91-108, 133-152, 165-187 and 191-208 522373004800 HMMPfam hit to PF07681, DoxX, score 3.8e-22 522373004801 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373004802 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 522373004803 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373004804 catalytic residues [active] 522373004805 1 probable transmembrane helix predicted for Smlt1217 by TMHMM2.0 at aa 7-26 522373004806 HMMPfam hit to PF08534, Redoxin, score 0.00041 522373004807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373004808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373004809 active site 522373004810 phosphorylation site [posttranslational modification] 522373004811 intermolecular recognition site; other site 522373004812 dimerization interface [polypeptide binding]; other site 522373004813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373004814 DNA binding site [nucleotide binding] 522373004815 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.4e-39 522373004816 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 6e-18 522373004817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 522373004818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373004819 ATP binding site [chemical binding]; other site 522373004820 Mg2+ binding site [ion binding]; other site 522373004821 G-X-G motif; other site 522373004822 2 probable transmembrane helices predicted for Smlt1219 by TMHMM2.0 at aa 20-39 and 155-177 522373004823 HMMPfam hit to PF00672, HAMP domain, score 2.7e-11 522373004824 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.3e-05 522373004825 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.2e-27 522373004826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373004827 metabolite-proton symporter; Region: 2A0106; TIGR00883 522373004828 putative substrate translocation pore; other site 522373004829 12 probable transmembrane helices predicted for Smlt1221 by TMHMM2.0 at aa 7-29, 44-66, 79-101, 111-133, 146-168, 178-200, 235-257, 267-289, 296-318, 322-344, 356-378 and 388-410 522373004830 HMMPfam hit to PF00083, Sugar (and other) transporter score 6e-12 522373004831 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.3e-24 522373004832 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 522373004833 active site 522373004834 HMMPfam hit to PF01156, Inosine-uridine preferring nucleoside hy, score 6.6e-65 522373004835 2 probable transmembrane helices predicted for Smlt1223 by TMHMM2.0 at aa 19-41 and 51-73 522373004836 Transcriptional regulators [Transcription]; Region: GntR; COG1802 522373004837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373004838 DNA-binding site [nucleotide binding]; DNA binding site 522373004839 FCD domain; Region: FCD; pfam07729 522373004840 HMMPfam hit to PF07729, FCD domain, score 6.2e-21 522373004841 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.4e-11 522373004842 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 522373004843 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 522373004844 10 probable transmembrane helices predicted for Smlt1225 by TMHMM2.0 at aa 10-41, 48-70, 90-124, 137-159, 174-196, 266-288, 308-330, 343-365, 380-402 and 430-452 522373004845 HMMPfam hit to PF03600, Citrate transporter score 0.00011 522373004846 HMMPfam hit to PF07158, Dicarboxylate carrier protein MatC N-terminu, score 1.4e-93 522373004847 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 522373004848 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 522373004849 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 522373004850 HMMPfam hit to PF01874, ATP:dephospho-CoA triphosphoribosyl transfer, score 2.8e-41 522373004851 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 522373004852 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 522373004853 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 522373004854 HMMPfam hit to PF06833, Malonate decarboxylase gamma subunit (MdcE), score 1.3e-118 522373004855 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 522373004856 1 probable transmembrane helix predicted for Smlt1230 by TMHMM2.0 at aa 138-160 522373004857 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 522373004858 HMMPfam hit to PF06857, Malonate decarboxylase delta subunit (MdcD), score 8.9e-46 522373004859 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 522373004860 Coenzyme A transferase; Region: CoA_trans; cl17247 522373004861 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 522373004862 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373004863 N-terminal plug; other site 522373004864 ligand-binding site [chemical binding]; other site 522373004865 HMMPfam hit to PF00593, TonB dependent receptor, score 6.4e-27 522373004866 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 7.1e-16 522373004867 malate:quinone oxidoreductase; Validated; Region: PRK05257 522373004868 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 522373004869 HMMPfam hit to PF06039, Malate:quinone oxidoreductase (Mqo), score 0 522373004870 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 3.1e-06 522373004871 1 probable transmembrane helix predicted for Smlt1234 by TMHMM2.0 at aa 52-74 522373004872 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 522373004873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373004874 Coenzyme A binding pocket [chemical binding]; other site 522373004875 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.7e-13 522373004876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 522373004877 binding surface 522373004878 TPR motif; other site 522373004879 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.00015 522373004880 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 522373004881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373004882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373004883 dimerization interface [polypeptide binding]; other site 522373004884 HMMPfam hit to PF03466, LysR substrate binding domain, score 0.0002 522373004885 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 7.1e-15 522373004886 LysE type translocator; Region: LysE; cl00565 522373004887 5 probable transmembrane helices predicted for Smlt1238 by TMHMM2.0 at aa 15-37, 48-70, 75-97, 151-173 and 188-210 522373004888 HMMPfam hit to PF01810, LysE type translocator, score 2.1e-30 522373004889 putative prolyl oligopeptidase, pseudogene;similarity:fasta; BB3096; bbronchiseptica; putative peptidase; length 637 aa; id=31.8%; E()=3.7e-40; 677 aa overlap; query 3-656 aa; subject 6-635 aa; similarity:fasta; BP0906; bpertussis; putative peptidase; length 637 aa; id=31.8%; E()=4e-40; 677 aa overlap; query 3-656 aa; subject 6-635 aa; similarity:fasta; BPP1632; bparapertussis; putative peptidase; length 637 aa; id=31.8%; E()=9.2e-40; 677 aa overlap; query 3-656 aa; subject 6-635 aa; similarity:blastp; with=UniProt:Q8PN73 (EMBL:AE011749;); Xanthomonas axonopodis pv. citri.; Prolyl oligopeptidase family protein.; length=652; E()=0.0; similarity:fasta; with=UniProt:Q8PN73 (EMBL:AE011749;); Xanthomonas axonopodis pv. citri.; Prolyl oligopeptidase family protein.; length=652; id 54.790%; ungapped id 57.098%; E()=2e-113; 668 aa overlap; query 3-661; subject 2-651 522373004890 1 probable transmembrane helix predicted for Smlt1239 by TMHMM2.0 at aa 5-27 522373004891 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 9.3e-42 522373004892 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 522373004893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373004894 POT family; Region: PTR2; cl17359 522373004895 15 probable transmembrane helices predicted for Smlt1241 by TMHMM2.0 at aa 53-75, 87-109, 119-138, 159-181, 186-208, 235-257, 267-289, 301-318, 347-369, 382-404, 408-430, 443-462, 477-499, 512-534 and 554-576 522373004896 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 0.00047 522373004897 HMMPfam hit to PF00854, POT family, score 1.9e-22 522373004898 Predicted membrane protein [Function unknown]; Region: COG3503 522373004899 9 probable transmembrane helices predicted for Smlt1242 by TMHMM2.0 at aa 55-77, 90-112, 118-140, 145-164, 196-213, 225-243, 274-291, 312-334 and 344-366 522373004900 HMMPfam hit to PF07786, Protein of unknown function (DUF1624), score 0.0002 522373004901 Predicted membrane protein [Function unknown]; Region: COG1297 522373004902 putative oligopeptide transporter, OPT family; Region: TIGR00733 522373004903 HMMPfam hit to PF03169, OPT oligopeptide transporter protein, score 1.5e-177 522373004904 16 probable transmembrane helices predicted for Smlt1245 by TMHMM2.0 at aa 20-42, 46-68, 80-102, 106-125, 213-235, 250-269, 274-291, 325-344, 356-378, 383-402, 415-437, 457-479, 511-533, 553-575, 596-618 and 633-652 522373004905 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 522373004906 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373004907 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 4.9e-71 522373004908 Protein of unknown function (DUF819); Region: DUF819; pfam05684 522373004909 12 probable transmembrane helices predicted for Smlt1247 by TMHMM2.0 at aa 7-24, 34-56, 69-86, 96-118, 130-152, 162-184, 226-248, 263-282, 295-317, 322-341, 348-370 and 380-402 522373004910 HMMPfam hit to PF05684, Protein of unknown function (DUF819), score 8.5e-199 522373004911 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 522373004912 HMMPfam hit to PF03776, Septum formation topological specificity fac, score 9.2e-44 522373004913 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 522373004914 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 522373004915 Switch I; other site 522373004916 Switch II; other site 522373004917 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 2.9e-26 522373004918 septum formation inhibitor; Reviewed; Region: minC; PRK04596 522373004919 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 522373004920 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 522373004921 HMMPfam hit to PF03775, Septum formation inhibitor MinC, C-terminal, score 9.6e-51 522373004922 HMMPfam hit to PF05209, Septum formation inhibitor MinC, N-terminal, score 7.1e-30 522373004923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 522373004924 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 0.00051 522373004925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 522373004926 Histidine kinase; Region: HisKA_3; pfam07730 522373004927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373004928 ATP binding site [chemical binding]; other site 522373004929 Mg2+ binding site [ion binding]; other site 522373004930 G-X-G motif; other site 522373004931 5 probable transmembrane helices predicted for Smlt1254 by TMHMM2.0 at aa 10-29, 42-64, 79-101, 113-135 and 145-164 522373004932 HMMPfam hit to PF07730, Histidine kinase, score 2.1e-17 522373004933 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.8e-14 522373004934 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373004935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373004936 active site 522373004937 phosphorylation site [posttranslational modification] 522373004938 intermolecular recognition site; other site 522373004939 dimerization interface [polypeptide binding]; other site 522373004940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373004941 DNA binding residues [nucleotide binding] 522373004942 dimerization interface [polypeptide binding]; other site 522373004943 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.1e-37 522373004944 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.8e-24 522373004945 HMMPfam hit to PF04967, HTH DNA binding domain, score 0.0012 522373004946 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 522373004947 putative hydrophobic ligand binding site [chemical binding]; other site 522373004948 1 probable transmembrane helix predicted for Smlt1256 by TMHMM2.0 at aa 7-26 522373004949 Protein of unknown function (DUF423); Region: DUF423; cl01008 522373004950 4 probable transmembrane helices predicted for Smlt1257 by TMHMM2.0 at aa 40-59, 74-93, 100-122 and 126-148 522373004951 HMMPfam hit to PF04241, Protein of unknown function (DUF423), score 3.4e-08 522373004952 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 522373004953 HMMPfam hit to PF02557, D-alanyl-D-alanine carboxypeptidase, score 4e-49 522373004954 2 probable transmembrane helices predicted for Smlt1260 by TMHMM2.0 at aa 17-39 and 59-81 522373004955 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 522373004956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 522373004957 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 522373004958 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 522373004959 HMMPfam hit to PF01145, SPFH domain / Band, score 1.8e-13 522373004960 1 probable transmembrane helix predicted for Smlt1263 by TMHMM2.0 at aa 2-24 522373004961 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 522373004962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373004963 ATP-grasp domain; Region: ATP-grasp; pfam02222 522373004964 HMMPfam hit to PF02222, ATP-grasp domain, score 2e-93 522373004965 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 8.7e-05 522373004966 1 probable transmembrane helix predicted for Smlt1265 by TMHMM2.0 at aa 9-31 522373004967 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 522373004968 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 522373004969 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 522373004970 HMMPfam hit to PF04377, Arginine-tRNA-protein transferase, C terminu, score 5.4e-59 522373004971 HMMPfam hit to PF04376, Arginine-tRNA-protein transferase, N terminu, score 5.4e-37 522373004972 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 522373004973 EF-hand domain pair; Region: EF_hand_5; pfam13499 522373004974 Ca2+ binding site [ion binding]; other site 522373004975 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 522373004976 EF-hand domain pair; Region: EF_hand_5; pfam13499 522373004977 Ca2+ binding site [ion binding]; other site 522373004978 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 522373004979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373004980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373004981 DNA binding residues [nucleotide binding] 522373004982 6 probable transmembrane helices predicted for Smlt1269 by TMHMM2.0 at aa 236-258, 270-292, 302-324, 337-359, 363-385 and 412-434 522373004983 HMMPfam hit to PF04545, Sigma-70, region, score 9.1e-08 522373004984 HMMPfam hit to PF08281, Sigma-70, region, score 7e-13 522373004985 HMMPfam hit to PF04542, Sigma-70 region, score 3.1e-16 522373004986 1 probable transmembrane helix predicted for Smlt1270 by TMHMM2.0 at aa 109-126 522373004987 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 522373004988 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 522373004989 active site 522373004990 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 522373004991 catalytic triad [active] 522373004992 dimer interface [polypeptide binding]; other site 522373004993 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 6.1e-45 522373004994 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 1.5e-27 522373004995 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 522373004996 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 522373004997 substrate binding site [chemical binding]; other site 522373004998 oxyanion hole (OAH) forming residues; other site 522373004999 trimer interface [polypeptide binding]; other site 522373005000 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 1.8e-40 522373005001 Protein of unknown function (DUF461); Region: DUF461; pfam04314 522373005002 HMMPfam hit to PF04314, Protein of unknown function (DUF461), score 1.4e-21 522373005003 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 522373005004 active site 522373005005 HMMPfam hit to PF03061, Thioesterase superfamily, score 2.4e-13 522373005006 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 522373005007 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 522373005008 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 522373005009 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 522373005010 HMMPfam hit to PF00005, ABC transporter score 1e-32 522373005011 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 522373005012 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 522373005013 HMMPfam hit to PF00829, Ribosomal prokaryotic L21 protein, score 2e-52 522373005014 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 522373005015 HMMPfam hit to PF01016, Ribosomal L27 protein, score 8.9e-51 522373005016 GTPase CgtA; Reviewed; Region: obgE; PRK12299 522373005017 GTP1/OBG; Region: GTP1_OBG; pfam01018 522373005018 Obg GTPase; Region: Obg; cd01898 522373005019 G1 box; other site 522373005020 GTP/Mg2+ binding site [chemical binding]; other site 522373005021 Switch I region; other site 522373005022 G2 box; other site 522373005023 G3 box; other site 522373005024 Switch II region; other site 522373005025 G4 box; other site 522373005026 G5 box; other site 522373005027 HMMPfam hit to PF01018, GTP1/OBG, score 6.2e-91 522373005028 HMMPfam hit to PF01926, GTPase of unknown function, score 2.3e-40 522373005029 Uncharacterized conserved small protein [Function unknown]; Region: COG5639 522373005030 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 522373005031 HMMPfam hit to PF03743, Bacterial conjugation TrbI-like protein, score 3.9e-91 522373005032 1 probable transmembrane helix predicted for Smlt1283 by TMHMM2.0 at aa 39-58 522373005033 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 522373005034 VirB7 interaction site; other site 522373005035 HMMPfam hit to PF03524, Conjugal transfer protein, score 5.5e-92 522373005036 conjugal transfer protein TrbF; Provisional; Region: PRK13872 522373005037 HMMPfam hit to PF04585, Conjugal transfer protein, score 1.7e-98 522373005038 1 probable transmembrane helix predicted for Smlt1285 by TMHMM2.0 at aa 43-61 522373005039 conjugal transfer protein TrbL; Provisional; Region: PRK13875 522373005040 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 522373005041 7 probable transmembrane helices predicted for Smlt1286 by TMHMM2.0 at aa 29-51, 68-90, 140-162, 167-189, 204-226, 246-268 and 283-305 522373005042 HMMPfam hit to PF04610, TrbL/VirB6 plasmid conjugal transfer protein, score 2.4e-23 522373005043 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 522373005044 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 522373005045 1 probable transmembrane helix predicted for Smlt1287 by TMHMM2.0 at aa 7-29 522373005046 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 522373005047 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 522373005048 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 522373005049 Walker A motif; other site 522373005050 ATP binding site [chemical binding]; other site 522373005051 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 522373005052 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 522373005053 1 probable transmembrane helix predicted for Smlt1289 by TMHMM2.0 at aa 46-68 522373005054 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 522373005055 3 probable transmembrane helices predicted for Smlt1290 by TMHMM2.0 at aa 29-51, 66-88 and 101-123 522373005056 HMMPfam hit to PF04956, Conjugal transfer protein TrbC, score 3.2e-34 522373005057 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 522373005058 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 522373005059 ATP binding site [chemical binding]; other site 522373005060 Walker A motif; other site 522373005061 hexamer interface [polypeptide binding]; other site 522373005062 Walker B motif; other site 522373005063 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 2.2e-105 522373005064 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 522373005065 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 522373005066 Walker A motif; other site 522373005067 ATP binding site [chemical binding]; other site 522373005068 Walker B motif; other site 522373005069 HMMPfam hit to PF02534, TraG/TraD family, score 5.8e-107 522373005070 2 probable transmembrane helices predicted for Smlt1293 by TMHMM2.0 at aa 7-29 and 74-96 522373005071 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 522373005072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373005073 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 522373005074 dimerization interface [polypeptide binding]; other site 522373005075 substrate binding pocket [chemical binding]; other site 522373005076 HMMPfam hit to PF03466, LysR substrate binding domain, score 3e-38 522373005077 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.7e-19 522373005078 putative regulator, pseudogene;similarity:fasta; with=UniProt:Q9XD61 (EMBL:AF112883;); Pseudomonas sp. (strain M1).; Regulator (Fragment).; length=39; id 53.571%; ungapped id 53.571%; E()=0.099; 28 aa overlap; query 1-28; subject 1-28 522373005079 putative esterase, pseudogene;Similar to C-terminus of uncultured bacterium pcosce1. estce UniProt:Q1I192 (EMBL:DQ022079 (388 aa) fasta scores: E()=2.3e-05, 57.143% id in 42 aa; similarity:fasta; with=UniProt:Q1I192 (EMBL:DQ022079;); uncultured bacterium pCosCE1.; estCE; Esterase.; length=388; id 57.143%; ungapped id 57.143%; E()=2.3e-05; 42 aa overlap; query 3-44; subject 340-381 522373005080 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 522373005081 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373005082 HMMPfam hit to PF02525, Flavodoxin-like fold, score 8.2e-69 522373005083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373005084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373005085 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 522373005086 putative substrate binding pocket [chemical binding]; other site 522373005087 putative dimerization interface [polypeptide binding]; other site 522373005088 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.6e-17 522373005089 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.2e-33 522373005090 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 522373005091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373005092 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 522373005093 dimerization interface [polypeptide binding]; other site 522373005094 substrate binding pocket [chemical binding]; other site 522373005095 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-36 522373005096 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.4e-18 522373005097 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 522373005098 HMMPfam hit to PF01436, NHL repeat, score 6.5 522373005099 HMMPfam hit to PF08450, SMP-30/Gluconolaconase/LRE-like region, score 1.9e-05 522373005100 HMMPfam hit to PF01436, NHL repeat, score 0.032 522373005101 HMMPfam hit to PF01436, NHL repeat, score 0.068 522373005102 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 522373005103 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 7.5e-29 522373005104 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 522373005105 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 522373005106 DNA binding residues [nucleotide binding] 522373005107 putative dimer interface [polypeptide binding]; other site 522373005108 HMMPfam hit to PF00376, MerR family regulatory protein, score 2.5e-13 522373005109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373005110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373005111 14 probable transmembrane helices predicted for Smlt1306 by TMHMM2.0 at aa 10-32, 45-67, 72-94, 101-123, 138-160, 167-184, 199-217, 224-246, 266-288, 301-323, 327-349, 356-378, 398-415 and 428-450 522373005112 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.6e-62 522373005113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373005114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373005115 dimerization interface [polypeptide binding]; other site 522373005116 LysR substrate binding domain; Region: LysR_substrate; pfam03466 522373005117 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.1e-12 522373005118 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.8e-25 522373005119 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 522373005120 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 522373005121 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 522373005122 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 522373005123 1 probable transmembrane helix predicted for Smlt1310 by TMHMM2.0 at aa 21-43 522373005124 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 522373005125 ParA-like protein; Provisional; Region: PHA02518 522373005126 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 522373005127 P-loop; other site 522373005128 Magnesium ion binding site [ion binding]; other site 522373005129 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 6e-26 522373005130 Replication initiator protein A; Region: RPA; pfam10134 522373005131 Helix-turn-helix domain; Region: HTH_17; cl17695 522373005132 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 522373005133 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 522373005134 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 522373005135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373005136 non-specific DNA binding site [nucleotide binding]; other site 522373005137 salt bridge; other site 522373005138 sequence-specific DNA binding site [nucleotide binding]; other site 522373005139 HMMPfam hit to PF01381, Helix-turn-helix, score 4.8e-11 522373005140 Uncharacterized conserved protein [Function unknown]; Region: COG5489 522373005141 HMMPfam hit to PF05284, Protein of unknown function (DUF736), score 2.7e-59 522373005142 Helix-turn-helix domain; Region: HTH_28; pfam13518 522373005143 Winged helix-turn helix; Region: HTH_29; pfam13551 522373005144 Winged helix-turn helix; Region: HTH_33; pfam13592 522373005145 DDE superfamily endonuclease; Region: DDE_3; pfam13358 522373005146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 522373005147 ParB-like nuclease domain; Region: ParBc; pfam02195 522373005148 HMMPfam hit to PF02195, ParB-like nuclease domain, score 2.9e-17 522373005149 Domain of unknown function (DUF932); Region: DUF932; pfam06067 522373005150 HMMPfam hit to PF06067, Domain of unknown function (DUF932), score 1.2e-226 522373005151 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 522373005152 3 probable transmembrane helices predicted for Smlt1331 by TMHMM2.0 at aa 330-352, 357-379 and 433-455 522373005153 putative RadC DNA repair protein, pseudogene;Codons 65 to 110 are similar to codons 150 to 195 of Escherichia coli RadC DNA repair protein RadC. UniProt:P25531 (222 aa) fasta scores: E()=0.052, 47.619% id in 42 aa, and codons 60 to 115 are similar to codons 95 to 145 of Ralstonia solanacearum (Pseudomonas solanacearum) RadC2 probable DNA repair radc-like protein. UniProt:Q8XW55 (169 aa) fasta scores: E()=3.2e-06, 69.388% id in 49 aa; similarity:fasta; with=UniProt:P25531; Escherichia coli.; radC; DNA repair protein radC.; length=222; id 47.619%; ungapped id 47.619%; E()=0.052; 42 aa overlap; query 65-106; subject 150-191; similarity:fasta; with=UniProt:Q8XW55; Ralstonia solanacearum (Pseudomonas solanacearum).; radC2; Probable dna repair radc-like protein.; length=169; id 69.388%; ungapped id 69.388%; E()=3.2e-06; 49 aa overlap; query 63-111; subject 95-143 522373005154 HMMPfam hit to PF04002, RadC, DNA repair protein, score 5e-05 522373005155 Predicted transcriptional regulator [Transcription]; Region: COG2944 522373005156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373005157 non-specific DNA binding site [nucleotide binding]; other site 522373005158 salt bridge; other site 522373005159 sequence-specific DNA binding site [nucleotide binding]; other site 522373005160 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 522373005161 HMMPfam hit to PF06296, Protein of unknown function (DUF1044), score 1.5e-30 522373005162 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 522373005163 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 522373005164 active site 522373005165 Int/Topo IB signature motif; other site 522373005166 DNA binding site [nucleotide binding] 522373005167 HMMPfam hit to PF00589, Phage integrase family, score 9e-08 522373005168 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 522373005169 HMMPfam hit to PF01649, Ribosomal protein S20, score 2.7e-35 522373005170 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 522373005171 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 522373005172 13 probable transmembrane helices predicted for Smlt1338 by TMHMM2.0 at aa 29-48, 94-116, 131-153, 160-182, 192-210, 239-261, 281-303, 322-344, 359-381, 394-416, 436-458, 471-493 and 508-530 522373005173 HMMPfam hit to PF03023, MviN-like protein, score 4.1e-132 522373005174 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 522373005175 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 522373005176 active site 522373005177 Riboflavin kinase; Region: Flavokinase; pfam01687 522373005178 HMMPfam hit to PF06574, FAD synthetase, score 6.6e-70 522373005179 HMMPfam hit to PF01687, Riboflavin kinase, score 2.7e-48 522373005180 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 522373005181 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 522373005182 active site 522373005183 HIGH motif; other site 522373005184 nucleotide binding site [chemical binding]; other site 522373005185 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 522373005186 active site 522373005187 KMSKS motif; other site 522373005188 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 522373005189 tRNA binding surface [nucleotide binding]; other site 522373005190 anticodon binding site; other site 522373005191 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 522373005192 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 7.6e-270 522373005193 HMMPfam hit to PF08264, Anticodon-binding domain, score 6.1e-42 522373005194 HMMPfam hit to PF06827, Zinc finger found in FPG and IleRS, score 1.2e-11 522373005195 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 522373005196 lipoprotein signal peptidase; Provisional; Region: PRK14787 522373005197 4 probable transmembrane helices predicted for Smlt1341 by TMHMM2.0 at aa 9-26, 72-89, 96-115 and 135-157 522373005198 HMMPfam hit to PF01252, Signal peptidase (SPase) II, score 4.3e-58 522373005199 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 522373005200 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 522373005201 HMMPfam hit to PF02401, LytB protein, score 8.3e-164 522373005202 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 522373005203 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 522373005204 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 522373005205 HMMPfam hit to PF05299, M61 glycyl aminopeptidase, score 6.1e-68 522373005206 YhhN-like protein; Region: YhhN; pfam07947 522373005207 8 probable transmembrane helices predicted for Smlt1344 by TMHMM2.0 at aa 7-24, 29-47, 60-77, 81-100, 107-129, 139-156, 169-191 and 195-217 522373005208 HMMPfam hit to PF07947, YhhN-like protein, score 4.1e-51 522373005209 1 probable transmembrane helix predicted for Smlt1345 by TMHMM2.0 at aa 9-31 522373005210 4 probable transmembrane helices predicted for Smlt1346 by TMHMM2.0 at aa 7-29, 44-66, 173-190 and 205-227 522373005211 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373005212 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373005213 N-terminal plug; other site 522373005214 ligand-binding site [chemical binding]; other site 522373005215 HMMPfam hit to PF00593, TonB dependent receptor, score 5.4e-12 522373005216 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.8e-18 522373005217 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 522373005218 FecR protein; Region: FecR; pfam04773 522373005219 HMMPfam hit to PF04773, FecR protein, score 2.5e-22 522373005220 1 probable transmembrane helix predicted for Smlt1348 by TMHMM2.0 at aa 84-106 522373005221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373005222 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 522373005223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373005224 DNA binding residues [nucleotide binding] 522373005225 HMMPfam hit to PF04545, Sigma-70, region, score 3e-09 522373005226 HMMPfam hit to PF08281, Sigma-70, region, score 3.8e-14 522373005227 HMMPfam hit to PF04542, Sigma-70 region, score 2.7e-05 522373005228 Autotransporter beta-domain; Region: Autotransporter; pfam03797 522373005229 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.8e-25 522373005230 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 522373005231 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 522373005232 putative ligand binding site [chemical binding]; other site 522373005233 putative NAD binding site [chemical binding]; other site 522373005234 catalytic site [active] 522373005235 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 6.2e-35 522373005236 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 2.8e-77 522373005237 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT, C-terminal do, score 0.00022 522373005238 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 522373005239 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 522373005240 3 probable transmembrane helices predicted for Smlt1358 by TMHMM2.0 at aa 20-42, 46-68 and 81-103 522373005241 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 522373005242 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 522373005243 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 522373005244 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 522373005245 3 probable transmembrane helices predicted for Smlt1360 by TMHMM2.0 at aa 13-32, 47-69 and 90-112 522373005246 HMMPfam hit to PF00116, Cytochrome C oxidase subunit II, periplasmic, score 8.8e-06 522373005247 HMMPfam hit to PF06481, COX Aromatic Rich Motif, score 7.4e-07 522373005248 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 522373005249 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 522373005250 D-pathway; other site 522373005251 Putative ubiquinol binding site [chemical binding]; other site 522373005252 Low-spin heme (heme b) binding site [chemical binding]; other site 522373005253 Putative water exit pathway; other site 522373005254 Binuclear center (heme o3/CuB) [ion binding]; other site 522373005255 K-pathway; other site 522373005256 Putative proton exit pathway; other site 522373005257 14 probable transmembrane helices predicted for Smlt1361 by TMHMM2.0 at aa 15-37, 58-80, 106-128, 141-163, 192-214, 234-256, 276-298, 310-332, 347-369, 382-404, 419-441, 458-480, 495-517 and 591-613 522373005258 HMMPfam hit to PF00115, Cytochrome C and Quinol oxidase polypeptide, score 1.3e-259 522373005259 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 522373005260 Subunit I/III interface [polypeptide binding]; other site 522373005261 Subunit III/IV interface [polypeptide binding]; other site 522373005262 HMMPfam hit to PF00510, Cytochrome c oxidase subunit III, score 1.3e-05 522373005263 5 probable transmembrane helices predicted for Smlt1362 by TMHMM2.0 at aa 35-57, 77-99, 106-128, 143-165 and 186-208 522373005264 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 522373005265 HMMPfam hit to PF03626, Prokaryotic Cytochrome C oxidase subunit IV, score 5e-40 522373005266 3 probable transmembrane helices predicted for Smlt1363 by TMHMM2.0 at aa 20-42, 52-71 and 83-105 522373005267 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 522373005268 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 522373005269 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 522373005270 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373005271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373005272 metal binding site [ion binding]; metal-binding site 522373005273 active site 522373005274 I-site; other site 522373005275 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373005276 HMMPfam hit to PF00563, EAL domain, score 2.2e-125 522373005277 HMMPfam hit to PF00990, GGDEF domain, score 2.1e-61 522373005278 HMMPfam hit to PF03707, Bacterial signalling protein N terminal repe, score 2.3e-06 522373005279 7 probable transmembrane helices predicted for Smlt1365 by TMHMM2.0 at aa 5-25, 38-60, 75-97, 106-128, 138-160, 173-195 and 215-237 522373005280 HMMPfam hit to PF03707, Bacterial signalling protein N terminal repe, score 5.3e-18 522373005281 HMMPfam hit to PF03707, Bacterial signalling protein N terminal repe, score 1.4e-22 522373005282 DNA repair protein RadA; Provisional; Region: PRK11823 522373005283 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 522373005284 Walker A motif/ATP binding site; other site 522373005285 ATP binding site [chemical binding]; other site 522373005286 Walker B motif; other site 522373005287 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 522373005288 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 522373005289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 522373005290 ATP binding site [chemical binding]; other site 522373005291 Mg2+ binding site [ion binding]; other site 522373005292 G-X-G motif; other site 522373005293 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 522373005294 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 2.2e-40 522373005295 8 probable transmembrane helices predicted for Smlt1370 by TMHMM2.0 at aa 4-22, 29-51, 61-83, 90-109, 124-146, 171-193, 203-222 and 234-256 522373005296 signal recognition particle protein; Provisional; Region: PRK10867 522373005297 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 522373005298 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 522373005299 P loop; other site 522373005300 GTP binding site [chemical binding]; other site 522373005301 Signal peptide binding domain; Region: SRP_SPB; pfam02978 522373005302 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 3.1e-31 522373005303 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 8.6e-111 522373005304 HMMPfam hit to PF02978, Signal peptide binding domain, score 1.5e-46 522373005305 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 522373005306 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 522373005307 FMN binding site [chemical binding]; other site 522373005308 substrate binding site [chemical binding]; other site 522373005309 putative catalytic residue [active] 522373005310 HMMPfam hit to PF03060, 2-nitropropane dioxygenase, score 4e-54 522373005311 1 probable transmembrane helix predicted for Smlt1372 by TMHMM2.0 at aa 21-43 522373005312 hypothetical protein; Provisional; Region: PRK09266 522373005313 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 522373005314 homodimer interface [polypeptide binding]; other site 522373005315 substrate-cofactor binding pocket; other site 522373005316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373005317 catalytic residue [active] 522373005318 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 522373005319 HMMPfam hit to PF00886, Ribosomal protein S16, score 2.5e-31 522373005320 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 522373005321 RimM N-terminal domain; Region: RimM; pfam01782 522373005322 PRC-barrel domain; Region: PRC; pfam05239 522373005323 HMMPfam hit to PF01782, RimM N-terminal domain, score 5e-29 522373005324 HMMPfam hit to PF05239, PRC-barrel domain, score 1e-12 522373005325 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 522373005326 HMMPfam hit to PF01746, tRNA (Guanine-1)-methyltransferase, score 2.4e-58 522373005327 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 522373005328 HMMPfam hit to PF01245, Ribosomal protein L19, score 8.2e-53 522373005329 2 probable transmembrane helices predicted for Smlt1378 by TMHMM2.0 at aa 48-70 and 85-104 522373005330 Uncharacterized conserved protein [Function unknown]; Region: COG5649 522373005331 Uncharacterized conserved protein [Function unknown]; Region: COG5649 522373005332 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 522373005333 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 522373005334 11 probable transmembrane helices predicted for Smlt1381 by TMHMM2.0 at aa 60-82, 94-116, 136-158, 170-192, 197-219, 240-271, 291-313, 326-345, 365-387, 392-409 and 424-446 522373005335 HMMPfam hit to PF01554, MatE, score 1.5e-34 522373005336 HMMPfam hit to PF01554, MatE, score 8.4e-32 522373005337 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373005338 RNA binding surface [nucleotide binding]; other site 522373005339 HMMPfam hit to PF01479, S4 domain, score 3.1e-10 522373005340 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 522373005341 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 522373005342 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 522373005343 tetramer interface [polypeptide binding]; other site 522373005344 heme binding pocket [chemical binding]; other site 522373005345 NADPH binding site [chemical binding]; other site 522373005346 HMMPfam hit to PF00199, Catalase, score 4.1e-274 522373005347 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 522373005348 MutS domain I; Region: MutS_I; pfam01624 522373005349 MutS domain II; Region: MutS_II; pfam05188 522373005350 MutS domain III; Region: MutS_III; pfam05192 522373005351 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 522373005352 Walker A/P-loop; other site 522373005353 ATP binding site [chemical binding]; other site 522373005354 Q-loop/lid; other site 522373005355 ABC transporter signature motif; other site 522373005356 Walker B; other site 522373005357 D-loop; other site 522373005358 H-loop/switch region; other site 522373005359 HMMPfam hit to PF00488, MutS domain V, score 2.1e-158 522373005360 HMMPfam hit to PF05192, MutS domain III, score 1e-76 522373005361 HMMPfam hit to PF05190, MutS family domain IV, score 4.7e-42 522373005362 HMMPfam hit to PF05188, MutS domain II, score 7.6e-41 522373005363 HMMPfam hit to PF01624, MutS domain I, score 5.2e-72 522373005364 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 522373005365 RNAase interaction site [polypeptide binding]; other site 522373005366 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 522373005367 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 522373005368 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 522373005369 HMMPfam hit to PF08479, POTRA domain, ShlB-type, score 1.4e-25 522373005370 HMMPfam hit to PF03865, Haemolysin secretion/activation protein ShlB, score 5.6e-09 522373005371 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 522373005372 haemagglutination activity domain; Region: Haemagg_act; pfam05860 522373005373 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 522373005374 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 522373005375 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 522373005376 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 522373005377 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 522373005378 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 522373005379 HMMPfam hit to PF05860, haemagglutination activity domain, score 3.1e-43 522373005380 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.00045 522373005381 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.8 522373005382 HMMPfam hit to PF05594, Haemagluttinin repeat, score 3.9 522373005383 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.96 522373005384 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.2 522373005385 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.0037 522373005386 HMMPfam hit to PF05594, Haemagluttinin repeat, score 8.6e-06 522373005387 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.00091 522373005388 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.5 522373005389 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.8 522373005390 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.013 522373005391 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.0044 522373005392 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.00014 522373005393 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.005 522373005394 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.00058 522373005395 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.047 522373005396 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.017 522373005397 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.3 522373005398 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.7 522373005399 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.3 522373005400 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.4 522373005401 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.3 522373005402 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.8 522373005403 HMMPfam hit to PF05594, Haemagluttinin repeat, score 3.1 522373005404 putative heamagglutinin/hemolysin related protein, pseudogene;Similar to Photorhabdus luminescens subsp. laumondii. similar to hemagglutinin/hemolysin-related proteins. putative transmembrane protein. UniProt:Q7MB03 (EMBL:BX571871 (3027 aa) fasta scores: E()=3e-38, 33.287% id in 724 aa; similarity:fasta; with=UniProt:Q7MB03 (EMBL:BX571871;); Photorhabdus luminescens subsp. laumondii.; Similar to hemagglutinin/hemolysin-related proteins. Putative transmembrane protein.; length=3027; id 33.287%; ungapped id 37.134%; E()=3e-38; 724 aa overlap; query 642-1328; subject 2340-3025 522373005405 putative heamagglutinin/heamolysin, pseudogene;Codons 15 to 2540 are similar to codons 2180 to 2540 of Photorhabdus luminescens subsp. laumondii. similarities with c-terminal region of hemagglutinin/hemolysin-related protein. UniProt:Q7N917 (EMBL:BX571860 (940 aa) fasta scores: E()=3.7e-20, 31.207% id in 439 aa; similarity:fasta; with=UniProt:Q7N917 (EMBL:BX571860;); Photorhabdus luminescens subsp. laumondii.; Similarities with C-terminal region of hemagglutinin/hemolysin-related protein.; length=940; id 31.207%; ungapped id 34.165%; E()=3.7e-20; 439 aa overlap; query 18-432; subject 329-753 522373005406 Protein of unknown function, DUF596; Region: DUF596; pfam04591 522373005407 HMMPfam hit to PF04591, Protein of unknown function, DUF596, score 1.4e-11 522373005408 3 probable transmembrane helices predicted for Smlt1400 by TMHMM2.0 at aa 82-104, 109-131 and 152-174 522373005409 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 522373005410 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 522373005411 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 522373005412 dimerization interface [polypeptide binding]; other site 522373005413 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373005414 dimer interface [polypeptide binding]; other site 522373005415 putative CheW interface [polypeptide binding]; other site 522373005416 2 probable transmembrane helices predicted for Smlt1402 by TMHMM2.0 at aa 15-37 and 187-209 522373005417 HMMPfam hit to PF00672, HAMP domain, score 2.5e-13 522373005418 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.6e-101 522373005419 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 1e-13 522373005420 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 522373005421 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 522373005422 ABC-2 type transporter; Region: ABC2_membrane; cl17235 522373005423 6 probable transmembrane helices predicted for Smlt1404 by TMHMM2.0 at aa 20-39, 180-202, 219-241, 256-278, 285-307 and 344-366 522373005424 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 522373005425 6 probable transmembrane helices predicted for Smlt1405 by TMHMM2.0 at aa 30-49, 191-213, 233-255, 270-292, 299-321 and 357-379 522373005426 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 522373005427 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373005428 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373005429 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.8e-12 522373005430 1 probable transmembrane helix predicted for Smlt1406 by TMHMM2.0 at aa 21-38 522373005431 Outer membrane efflux protein; Region: OEP; pfam02321 522373005432 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 522373005433 Switch II region; other site 522373005434 G3 box; other site 522373005435 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.7e-20 522373005436 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.00043 522373005437 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 522373005438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373005439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373005440 dimerization interface [polypeptide binding]; other site 522373005441 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.1e-09 522373005442 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.9e-17 522373005443 LysE type translocator; Region: LysE; cl00565 522373005444 6 probable transmembrane helices predicted for Smlt1409 by TMHMM2.0 at aa 5-27, 40-62, 72-93, 113-135, 145-167 and 179-201 522373005445 HMMPfam hit to PF01810, LysE type translocator, score 4.9e-44 522373005446 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 522373005447 active site 522373005448 HMMPfam hit to PF00557, metallopeptidase family M24, score 2.6e-72 522373005449 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 522373005450 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 522373005451 dimer interface [polypeptide binding]; other site 522373005452 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373005453 ligand binding site [chemical binding]; other site 522373005454 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 1.7e-11 522373005455 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 522373005456 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 522373005457 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 522373005458 inhibitor-cofactor binding pocket; inhibition site 522373005459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373005460 catalytic residue [active] 522373005461 HMMPfam hit to PF00202, Aminotransferase class-III, score 8.4e-64 522373005462 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 522373005463 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 522373005464 HMMPfam hit to PF06888, Putative Phosphatase, score 1.5e-05 522373005465 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 522373005466 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373005467 catalytic residue [active] 522373005468 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 8.3e-13 522373005469 4 probable transmembrane helices predicted for Smlt1418 by TMHMM2.0 at aa 5-27, 47-67, 72-94 and 98-117 522373005470 3 probable transmembrane helices predicted for Smlt1419 by TMHMM2.0 at aa 35-57, 62-81 and 88-105 522373005471 Esterase/lipase [General function prediction only]; Region: COG1647 522373005472 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373005473 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 0.00049 522373005474 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 522373005475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373005476 dimer interface [polypeptide binding]; other site 522373005477 phosphorylation site [posttranslational modification] 522373005478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373005479 ATP binding site [chemical binding]; other site 522373005480 Mg2+ binding site [ion binding]; other site 522373005481 G-X-G motif; other site 522373005482 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 6.4e-35 522373005483 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.2e-10 522373005484 2 probable transmembrane helices predicted for Smlt1421 by TMHMM2.0 at aa 15-36 and 162-184 522373005485 HMMPfam hit to PF08521, Two-component sensor kinase N-terminal, score 2.4e-12 522373005486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373005487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373005488 active site 522373005489 phosphorylation site [posttranslational modification] 522373005490 intermolecular recognition site; other site 522373005491 dimerization interface [polypeptide binding]; other site 522373005492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373005493 DNA binding site [nucleotide binding] 522373005494 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 4.5e-17 522373005495 HMMPfam hit to PF00072, Response regulator receiver domain, score 3e-32 522373005496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 522373005497 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 522373005498 active site 522373005499 metal binding site [ion binding]; metal-binding site 522373005500 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 3.6e-21 522373005501 6 probable transmembrane helices predicted for Smlt1424 by TMHMM2.0 at aa 21-43, 48-70, 77-99, 104-123, 140-162 and 167-189 522373005502 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 522373005503 heme-binding site [chemical binding]; other site 522373005504 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373005505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373005506 metal binding site [ion binding]; metal-binding site 522373005507 active site 522373005508 I-site; other site 522373005509 HMMPfam hit to PF00990, GGDEF domain, score 1.3e-59 522373005510 outer membrane receptor FepA; Provisional; Region: PRK13524 522373005511 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373005512 N-terminal plug; other site 522373005513 ligand-binding site [chemical binding]; other site 522373005514 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.3e-30 522373005515 HMMPfam hit to PF00593, TonB dependent receptor, score 1.3e-31 522373005516 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 522373005517 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 522373005518 6 probable transmembrane helices predicted for Smlt1428 by TMHMM2.0 at aa 86-108, 112-134, 154-176, 186-208, 220-242 and 252-269 522373005519 HMMPfam hit to PF01545, Cation efflux family, score 2.8e-108 522373005520 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 522373005521 Active_site [active] 522373005522 HMMPfam hit to PF04493, Endonuclease V, score 8.2e-78 522373005523 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 522373005524 catalytic core [active] 522373005525 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 522373005526 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 2e-43 522373005527 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 522373005528 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 522373005529 active site 522373005530 Zn binding site [ion binding]; other site 522373005531 HMMPfam hit to PF05649, Peptidase family M13, score 1.3e-182 522373005532 HMMPfam hit to PF01431, Peptidase family M13, score 9.5e-78 522373005533 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 522373005534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 522373005535 Zn2+ binding site [ion binding]; other site 522373005536 Mg2+ binding site [ion binding]; other site 522373005537 HMMPfam hit to PF01966, HD domain, score 2.9e-24 522373005538 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 522373005539 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 522373005540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373005541 ATP binding site [chemical binding]; other site 522373005542 putative Mg++ binding site [ion binding]; other site 522373005543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373005544 nucleotide binding region [chemical binding]; other site 522373005545 ATP-binding site [chemical binding]; other site 522373005546 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 522373005547 HMMPfam hit to PF03461, TRCF domain, score 1.3e-52 522373005548 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.9e-20 522373005549 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2e-40 522373005550 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 2.1e-06 522373005551 HMMPfam hit to PF02559, CarD-like/TRCF domain, score 9e-49 522373005552 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 522373005553 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 522373005554 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.2e-07 522373005555 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 522373005556 HMMPfam hit to PF04378, Protein of unknown function (DUF519), score 3.9e-125 522373005557 DNA-binding response regulator CreB; Provisional; Region: PRK11083 522373005558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373005559 active site 522373005560 phosphorylation site [posttranslational modification] 522373005561 intermolecular recognition site; other site 522373005562 dimerization interface [polypeptide binding]; other site 522373005563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373005564 DNA binding site [nucleotide binding] 522373005565 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.7e-35 522373005566 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2e-22 522373005567 sensory histidine kinase CreC; Provisional; Region: PRK11100 522373005568 HAMP domain; Region: HAMP; pfam00672 522373005569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373005570 dimer interface [polypeptide binding]; other site 522373005571 phosphorylation site [posttranslational modification] 522373005572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373005573 ATP binding site [chemical binding]; other site 522373005574 Mg2+ binding site [ion binding]; other site 522373005575 G-X-G motif; other site 522373005576 2 probable transmembrane helices predicted for Smlt1437 by TMHMM2.0 at aa 5-27 and 191-213 522373005577 HMMPfam hit to PF00672, HAMP domain, score 9.4e-10 522373005578 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 8.9e-14 522373005579 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 6.1e-32 522373005580 inner membrane protein; Provisional; Region: PRK11715 522373005581 HMMPfam hit to PF06123, Inner membrane protein CreD, score 1.4e-176 522373005582 6 probable transmembrane helices predicted for Smlt1438 by TMHMM2.0 at aa 10-32, 303-321, 326-348, 357-379, 383-402 and 407-426 522373005583 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 522373005584 M28 Zn-Peptidases; Region: M28_like_4; cd08015 522373005585 Peptidase family M28; Region: Peptidase_M28; pfam04389 522373005586 metal binding site [ion binding]; metal-binding site 522373005587 HMMPfam hit to PF04389, Peptidase family M28, score 1.5e-36 522373005588 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 7.3e-05 522373005589 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 522373005590 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 522373005591 active site 522373005592 HIGH motif; other site 522373005593 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 522373005594 active site 522373005595 KMSKS motif; other site 522373005596 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 1.7e-142 522373005597 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 522373005598 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 522373005599 metal binding site 2 [ion binding]; metal-binding site 522373005600 putative DNA binding helix; other site 522373005601 metal binding site 1 [ion binding]; metal-binding site 522373005602 dimer interface [polypeptide binding]; other site 522373005603 structural Zn2+ binding site [ion binding]; other site 522373005604 HMMPfam hit to PF01475, Ferric uptake regulator family, score 9.5e-07 522373005605 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 522373005606 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373005607 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373005608 HMMPfam hit to PF00529, HlyD family secretion protein, score 7.6e-37 522373005609 1 probable transmembrane helix predicted for Smlt1443 by TMHMM2.0 at aa 44-66 522373005610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373005611 putative substrate translocation pore; other site 522373005612 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 522373005613 14 probable transmembrane helices predicted for Smlt1444 by TMHMM2.0 at aa 35-57, 72-92, 99-121, 131-150, 157-179, 194-213, 226-248, 252-274, 286-308, 328-350, 355-372, 387-409, 422-444 and 515-537 522373005614 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.2e-06 522373005615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373005616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373005617 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 8.7e-10 522373005618 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373005619 N-terminal plug; other site 522373005620 ligand-binding site [chemical binding]; other site 522373005621 HMMPfam hit to PF00593, TonB dependent receptor, score 1.1e-22 522373005622 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8e-23 522373005623 MerC mercury resistance protein; Region: MerC; pfam03203 522373005624 4 probable transmembrane helices predicted for Smlt1447 by TMHMM2.0 at aa 93-115, 130-147, 154-176 and 180-202 522373005625 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 522373005626 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 522373005627 HMMPfam hit to PF01663, Type I phosphodiesterase / nucleotide py, score 2.8e-116 522373005628 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 522373005629 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 522373005630 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 522373005631 DNA binding site [nucleotide binding] 522373005632 active site 522373005633 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransfera, score 1.1e-44 522373005634 HMMPfam hit to PF02870, 6-O-methylguanine DNA methyltransfera, score 0.0022 522373005635 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 522373005636 Helix-turn-helix domain; Region: HTH_18; pfam12833 522373005637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373005638 AlkA N-terminal domain; Region: AlkA_N; pfam06029 522373005639 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 522373005640 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 522373005641 minor groove reading motif; other site 522373005642 helix-hairpin-helix signature motif; other site 522373005643 substrate binding pocket [chemical binding]; other site 522373005644 active site 522373005645 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA, score 5.3e-14 522373005646 HMMPfam hit to PF06029, AlkA N-terminal domain, score 1.1e-48 522373005647 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix, score 4.7e-08 522373005648 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix, score 0.00029 522373005649 HMMPfam hit to PF02805, Metal binding domain of Ada, score 1.8e-38 522373005650 Predicted periplasmic protein [Function unknown]; Region: COG3904 522373005651 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 522373005652 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 522373005653 MAPEG family; Region: MAPEG; cl09190 522373005654 3 probable transmembrane helices predicted for Smlt1458 by TMHMM2.0 at aa 5-27, 58-80 and 106-128 522373005655 hypothetical protein; Provisional; Region: PRK09126 522373005656 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 522373005657 HMMPfam hit to PF01494, FAD binding domain, score 7.7e-07 522373005658 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00055 522373005659 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373005660 RNA binding surface [nucleotide binding]; other site 522373005661 HMMPfam hit to PF01479, S4 domain, score 0.023 522373005662 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 522373005663 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 522373005664 ATP binding site [chemical binding]; other site 522373005665 Mg++ binding site [ion binding]; other site 522373005666 motif III; other site 522373005667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373005668 nucleotide binding region [chemical binding]; other site 522373005669 ATP-binding site [chemical binding]; other site 522373005670 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 522373005671 putative RNA binding site [nucleotide binding]; other site 522373005672 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.8e-73 522373005673 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.1e-33 522373005674 HMMPfam hit to PF03880, DbpA RNA binding domain, score 9.2e-35 522373005675 PAS domain S-box; Region: sensory_box; TIGR00229 522373005676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373005677 putative active site [active] 522373005678 heme pocket [chemical binding]; other site 522373005679 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373005680 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373005681 metal binding site [ion binding]; metal-binding site 522373005682 active site 522373005683 I-site; other site 522373005684 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373005685 2 probable transmembrane helices predicted for Smlt1462 by TMHMM2.0 at aa 18-40 and 210-232 522373005686 HMMPfam hit to PF00989, PAS fold, score 2.1e-07 522373005687 HMMPfam hit to PF08448, PAS fold, score 0.0025 522373005688 HMMPfam hit to PF00990, GGDEF domain, score 3.6e-56 522373005689 HMMPfam hit to PF00563, EAL domain, score 4.4e-68 522373005690 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373005691 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373005692 metal binding site [ion binding]; metal-binding site 522373005693 active site 522373005694 I-site; other site 522373005695 8 probable transmembrane helices predicted for Smlt1463 by TMHMM2.0 at aa 7-29, 165-187, 194-216, 231-253, 265-283, 293-310, 322-344 and 348-367 522373005696 HMMPfam hit to PF00990, GGDEF domain, score 4.9e-54 522373005697 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 522373005698 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373005699 RNA binding surface [nucleotide binding]; other site 522373005700 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 522373005701 probable active site [active] 522373005702 HMMPfam hit to PF01479, S4 domain, score 1.3e-08 522373005703 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.2e-12 522373005704 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 522373005705 GAF domain; Region: GAF; pfam01590 522373005706 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373005707 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373005708 metal binding site [ion binding]; metal-binding site 522373005709 active site 522373005710 I-site; other site 522373005711 HMMPfam hit to PF01590, GAF domain, score 1.6e-14 522373005712 HMMPfam hit to PF00990, GGDEF domain, score 1.5e-48 522373005713 Predicted ATPase [General function prediction only]; Region: COG4637 522373005714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373005715 Walker A/P-loop; other site 522373005716 ATP binding site [chemical binding]; other site 522373005717 Q-loop/lid; other site 522373005718 ABC transporter signature motif; other site 522373005719 D-loop; other site 522373005720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373005721 ABC transporter signature motif; other site 522373005722 Walker B; other site 522373005723 D-loop; other site 522373005724 H-loop/switch region; other site 522373005725 EamA-like transporter family; Region: EamA; pfam00892 522373005726 10 probable transmembrane helices predicted for Smlt1467 by TMHMM2.0 at aa 32-54, 59-81, 88-110, 115-137, 146-163, 167-189, 202-224, 239-261, 266-288 and 293-315 522373005727 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.9e-13 522373005728 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.5e-12 522373005729 Protein of unknown function DUF72; Region: DUF72; pfam01904 522373005730 HMMPfam hit to PF01904, Protein of unknown function DUF72, score 1.5e-56 522373005731 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 522373005732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373005733 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 5.9e-13 522373005734 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373005735 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373005736 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 522373005737 HMMPfam hit to PF00144, Beta-lactamase, score 4.9e-77 522373005738 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 522373005739 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 522373005740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373005741 Walker A/P-loop; other site 522373005742 ATP binding site [chemical binding]; other site 522373005743 Q-loop/lid; other site 522373005744 ABC transporter signature motif; other site 522373005745 Walker B; other site 522373005746 D-loop; other site 522373005747 H-loop/switch region; other site 522373005748 5 probable transmembrane helices predicted for Smlt1471 by TMHMM2.0 at aa 35-57, 83-105, 163-180, 184-203 and 272-291 522373005749 HMMPfam hit to PF00005, ABC transporter score 7.3e-61 522373005750 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 522373005751 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 522373005752 catalytic core [active] 522373005753 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 522373005754 HMMPfam hit to PF00328, Histidine acid phosphatase, score 1.5e-42 522373005755 poly(beta-D-mannuronate) lyase; Provisional; Region: algL; PRK00325 522373005756 active site 522373005757 HMMPfam hit to PF05426, Alginate lyase, score 4.1e-32 522373005758 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 522373005759 HMMPfam hit to PF05960, Bacterial protein of unknown function (DUF88, score 3e-14 522373005760 Uncharacterized conserved protein [Function unknown]; Region: COG3791 522373005761 HMMPfam hit to PF04828, Protein of unknown function (DUF636), score 1.3e-14 522373005762 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 522373005763 1 probable transmembrane helix predicted for Smlt1476 by TMHMM2.0 at aa 225-247 522373005764 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 522373005765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373005766 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 522373005767 dimerization interface [polypeptide binding]; other site 522373005768 substrate binding pocket [chemical binding]; other site 522373005769 HMMPfam hit to PF03466, LysR substrate binding domain, score 1e-36 522373005770 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.9e-16 522373005771 Similar to N-terminus of bpertussis putative membrane protein BP0712 (294 aa) fasta scores: E()=2.1e-19, id=44.6% id in 168 aa, and to N-terminus to codon 181 of Xanthomonas campestris pv. vesicatoria (strain 85-10) putative membrane protein. putative membrane protein. UniProt:Q3BRD5 (295 aa) fasta scores: E()=3.3e-41, 73.410% id in 173 aa; similarity:fasta; BP0712; bpertussis; putative membrane protein; length 294 aa; id=44.6%; E()=2.1e-19; 168 aa overlap; query 13-177 aa; subject 4-171 aa; similarity:fasta; with=UniProt:Q3BRD5; Xanthomonas campestris pv. vesicatoria (strain 85-10).; Putative membrane protein. Putative membrane protein.; length=295; id 73.410%; ungapped id 73.410%; E()=3.3e-41; 173 aa overlap; query 5-177; subject 9-181 522373005772 6 probable transmembrane helices predicted for Smlt1479 by TMHMM2.0 at aa 12-34, 38-60, 72-94, 99-121, 130-148 and 152-174 522373005773 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.8e-24 522373005774 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 2.5e-21 522373005775 putative transmembrane protein, pseudogene;similarity:fasta; BAV0118; bavium; putative membrane protein; length 295 aa; id=42.7%; E()=3.2e-15; 110 aa overlap; query 1-110 aa; subject 172-281 aa 522373005776 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 7.9e-11 522373005777 4 probable transmembrane helices predicted for Smlt1481 by TMHMM2.0 at aa 7-29, 39-61, 68-87 and 91-110 522373005778 1 probable transmembrane helix predicted for Smlt1482 by TMHMM2.0 at aa 67-89 522373005779 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 522373005780 active site 522373005781 Predicted transcriptional regulators [Transcription]; Region: COG1695 522373005782 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 522373005783 HMMPfam hit to PF03551, Transcriptional regulator PadR-like family, score 2.5e-28 522373005784 Predicted membrane protein [Function unknown]; Region: COG4709 522373005785 Putative sensor; Region: Sensor; pfam13796 522373005786 4 probable transmembrane helices predicted for Smlt1485 by TMHMM2.0 at aa 136-158, 162-184, 233-255 and 284-306 522373005787 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 522373005788 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 522373005789 HMMPfam hit to PF06850, PHB de-polymerase C-terminus, score 2.6e-144 522373005790 Methyltransferase domain; Region: Methyltransf_23; pfam13489 522373005791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373005792 S-adenosylmethionine binding site [chemical binding]; other site 522373005793 HMMPfam hit to PF08242, Methyltransferase domain, score 1.6e-10 522373005794 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 522373005795 HMMPfam hit to PF03653, Uncharacterised protein family (UPF0093), score 1.1e-23 522373005796 4 probable transmembrane helices predicted for Smlt1488 by TMHMM2.0 at aa 72-94, 115-137, 152-172 and 193-211 522373005797 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 522373005798 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 522373005799 HMMPfam hit to PF03255, Acetyl co-enzyme A carboxylase carboxyltrans, score 7.7e-91 522373005800 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 522373005801 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 522373005802 putative active site [active] 522373005803 putative PHP Thumb interface [polypeptide binding]; other site 522373005804 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 522373005805 generic binding surface II; other site 522373005806 generic binding surface I; other site 522373005807 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1e-10 522373005808 HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 1.8e-298 522373005809 HMMPfam hit to PF02811, PHP domain, score 1.8e-26 522373005810 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 522373005811 RNA/DNA hybrid binding site [nucleotide binding]; other site 522373005812 active site 522373005813 HMMPfam hit to PF01351, Ribonuclease HII, score 7.1e-61 522373005814 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 522373005815 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 522373005816 HMMPfam hit to PF02684, Lipid-A-disaccharide synthetase, score 7.5e-129 522373005817 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 522373005818 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 522373005819 active site 522373005820 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 96 522373005821 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 23 522373005822 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 13 522373005823 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 86 522373005824 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 27 522373005825 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0082 522373005826 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 31 522373005827 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 522373005828 HMMPfam hit to PF07977, FabA-like domain, score 5.1e-66 522373005829 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 522373005830 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 522373005831 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 522373005832 trimer interface [polypeptide binding]; other site 522373005833 active site 522373005834 UDP-GlcNAc binding site [chemical binding]; other site 522373005835 lipid binding site [chemical binding]; lipid-binding site 522373005836 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 11 522373005837 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 11 522373005838 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 37 522373005839 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.071 522373005840 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.4 522373005841 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4.6 522373005842 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.36 522373005843 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 25 522373005844 HMMPfam hit to PF04613, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-a, score 2.6e-40 522373005845 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 522373005846 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 522373005847 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 522373005848 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 522373005849 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 522373005850 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 522373005851 Surface antigen; Region: Bac_surface_Ag; pfam01103 522373005852 HMMPfam hit to PF01103, Surface antigen, score 8.7e-76 522373005853 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 3.8e-20 522373005854 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 2e-18 522373005855 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 4.1e-13 522373005856 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 4.9e-13 522373005857 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.3e-12 522373005858 zinc metallopeptidase RseP; Provisional; Region: PRK10779 522373005859 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 522373005860 active site 522373005861 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 522373005862 protein binding site [polypeptide binding]; other site 522373005863 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 522373005864 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 522373005865 HMMPfam hit to PF02163, Peptidase family M50, score 5.7e-85 522373005866 4 probable transmembrane helices predicted for Smlt1499 by TMHMM2.0 at aa 7-29, 98-120, 377-399 and 422-444 522373005867 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 522373005868 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 522373005869 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 522373005870 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 522373005871 HMMPfam hit to PF08436, 1-deoxy-D-xylulose 5-phosphate reduct, score 8.6e-63 522373005872 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reduct, score 2.5e-62 522373005873 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 522373005874 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 522373005875 HMMPfam hit to PF01148, Cytidylyltransferase family, score 1.8e-81 522373005876 8 probable transmembrane helices predicted for Smlt1501 by TMHMM2.0 at aa 5-23, 27-44, 57-74, 79-101, 113-135, 145-167, 187-209 and 214-236 522373005877 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 522373005878 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 522373005879 catalytic residue [active] 522373005880 putative FPP diphosphate binding site; other site 522373005881 putative FPP binding hydrophobic cleft; other site 522373005882 dimer interface [polypeptide binding]; other site 522373005883 putative IPP diphosphate binding site; other site 522373005884 HMMPfam hit to PF01255, Putative undecaprenyl diphosphate syntha, score 6.2e-108 522373005885 ribosome recycling factor; Reviewed; Region: frr; PRK00083 522373005886 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 522373005887 hinge region; other site 522373005888 HMMPfam hit to PF01765, Ribosome recycling factor, score 7.2e-73 522373005889 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 522373005890 putative nucleotide binding site [chemical binding]; other site 522373005891 uridine monophosphate binding site [chemical binding]; other site 522373005892 homohexameric interface [polypeptide binding]; other site 522373005893 HMMPfam hit to PF00696, Amino acid kinase family, score 6.5e-64 522373005894 HDOD domain; Region: HDOD; pfam08668 522373005895 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373005896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373005897 metal binding site [ion binding]; metal-binding site 522373005898 active site 522373005899 I-site; other site 522373005900 HMMPfam hit to PF00990, GGDEF domain, score 6.9e-56 522373005901 elongation factor Ts; Provisional; Region: tsf; PRK09377 522373005902 UBA/TS-N domain; Region: UBA; pfam00627 522373005903 Elongation factor TS; Region: EF_TS; pfam00889 522373005904 Elongation factor TS; Region: EF_TS; pfam00889 522373005905 HMMPfam hit to PF00889, Elongation factor TS, score 2.5e-68 522373005906 HMMPfam hit to PF00627, UBA/TS-N domain, score 6.4e-12 522373005907 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 522373005908 rRNA interaction site [nucleotide binding]; other site 522373005909 S8 interaction site; other site 522373005910 putative laminin-1 binding site; other site 522373005911 HMMPfam hit to PF00318, Ribosomal protein S2, score 1.1e-103 522373005912 Spore Coat Protein U domain; Region: SCPU; pfam05229 522373005913 HMMPfam hit to PF05229, Spore Coat Protein U domain, score 1e-12 522373005914 HMMPfam hit to PF05229, Spore Coat Protein U domain, score 0.00088 522373005915 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 522373005916 PapC N-terminal domain; Region: PapC_N; pfam13954 522373005917 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 522373005918 PapC C-terminal domain; Region: PapC_C; pfam13953 522373005919 HMMPfam hit to PF00577, Fimbrial Usher protein, score 1.3e-13 522373005920 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 522373005921 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 522373005922 Spore Coat Protein U domain; Region: SCPU; pfam05229 522373005923 HMMPfam hit to PF05229, Spore Coat Protein U domain, score 3.9e-10 522373005924 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 522373005925 active site 522373005926 PII uridylyl-transferase; Provisional; Region: PRK04374 522373005927 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 522373005928 metal binding triad; other site 522373005929 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 522373005930 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 522373005931 Zn2+ binding site [ion binding]; other site 522373005932 Mg2+ binding site [ion binding]; other site 522373005933 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 522373005934 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 522373005935 HMMPfam hit to PF01909, Nucleotidyltransferase domain, score 0.00092 522373005936 HMMPfam hit to PF08335, GlnD PII-uridylyltransferase, score 3.5e-86 522373005937 HMMPfam hit to PF01966, HD domain, score 7.5e-15 522373005938 HMMPfam hit to PF01842, ACT domain, score 0.12 522373005939 HMMPfam hit to PF01842, ACT domain, score 2.1e-08 522373005940 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 522373005941 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 522373005942 trimer interface [polypeptide binding]; other site 522373005943 active site 522373005944 substrate binding site [chemical binding]; other site 522373005945 CoA binding site [chemical binding]; other site 522373005946 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 8.4 522373005947 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 8.5 522373005948 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.11 522373005949 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 10 522373005950 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 522373005951 ArsC family; Region: ArsC; pfam03960 522373005952 putative catalytic residues [active] 522373005953 HMMPfam hit to PF03960, ArsC family, score 3.7e-40 522373005954 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 522373005955 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 522373005956 metal binding site [ion binding]; metal-binding site 522373005957 dimer interface [polypeptide binding]; other site 522373005958 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 3e-51 522373005959 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 5.9e-36 522373005960 asparagine synthetase B; Provisional; Region: asnB; PRK09431 522373005961 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 522373005962 active site 522373005963 dimer interface [polypeptide binding]; other site 522373005964 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 522373005965 Ligand Binding Site [chemical binding]; other site 522373005966 Molecular Tunnel; other site 522373005967 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 2.1e-13 522373005968 HMMPfam hit to PF00733, Asparagine synthase, score 2.2e-106 522373005969 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 522373005970 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 522373005971 12 probable transmembrane helices predicted for Smlt1521 by TMHMM2.0 at aa 20-42, 57-79, 92-114, 124-146, 159-181, 191-213, 230-252, 256-278, 295-317, 337-359, 372-394 and 435-457 522373005972 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 2.7e-81 522373005973 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 522373005974 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 522373005975 active site 522373005976 HMMPfam hit to PF01804, Penicillin amidase, score 9.8e-15 522373005977 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 522373005978 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 522373005979 heme binding site [chemical binding]; other site 522373005980 ferroxidase pore; other site 522373005981 ferroxidase diiron center [ion binding]; other site 522373005982 HMMPfam hit to PF00210, Ferritin-like domain, score 5.4e-26 522373005983 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 522373005984 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 522373005985 CAP-like domain; other site 522373005986 active site 522373005987 primary dimer interface [polypeptide binding]; other site 522373005988 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 6e-05 522373005989 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 0.034 522373005990 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 3.5e-247 522373005991 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 522373005992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373005993 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.1e-08 522373005994 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.0004 522373005995 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 522373005996 MarR family; Region: MarR_2; pfam12802 522373005997 HMMPfam hit to PF01047, MarR family, score 2.5e-14 522373005998 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 522373005999 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.9e-25 522373006000 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.5e-50 522373006001 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 522373006002 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373006003 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373006004 1 probable transmembrane helix predicted for Smlt1529 by TMHMM2.0 at aa 19-41 522373006005 HMMPfam hit to PF00529, HlyD family secretion protein, score 3.8e-67 522373006006 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 522373006007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373006008 putative substrate translocation pore; other site 522373006009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373006010 13 probable transmembrane helices predicted for Smlt1530 by TMHMM2.0 at aa 20-42, 69-91, 98-120, 130-149, 156-178, 184-206, 219-236, 251-268, 289-308, 318-340, 352-371, 381-403 and 490-512 522373006011 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.9e-62 522373006012 2 probable transmembrane helices predicted for Smlt1530A by TMHMM2.0 at aa 36-53 and 58-80 522373006013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373006014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373006015 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 522373006016 putative dimerization interface [polypeptide binding]; other site 522373006017 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-32 522373006018 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 9.6e-15 522373006019 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 522373006020 5 probable transmembrane helices predicted for Smlt1533 by TMHMM2.0 at aa 20-42, 49-71, 86-108, 115-134 and 139-161 522373006021 ribonuclease R; Region: RNase_R; TIGR02063 522373006022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 522373006023 putative DNA binding site [nucleotide binding]; other site 522373006024 putative Zn2+ binding site [ion binding]; other site 522373006025 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 522373006026 RNB domain; Region: RNB; pfam00773 522373006027 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 522373006028 RNA binding site [nucleotide binding]; other site 522373006029 HMMPfam hit to PF08206, Ribonuclease B OB domain, score 1.5e-26 522373006030 HMMPfam hit to PF00773, RNB-like protein, score 2.6e-91 522373006031 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.9e-13 522373006032 Uncharacterized conserved protein [Function unknown]; Region: COG3791 522373006033 HMMPfam hit to PF04828, Protein of unknown function (DUF636), score 6.2e-36 522373006034 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 522373006035 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 522373006036 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 522373006037 HMMPfam hit to PF08032, RNA 2'-O ribose methyltransferase subs, score 5.9e-17 522373006038 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 9.9e-62 522373006039 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 522373006040 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.7e-19 522373006041 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.2e-24 522373006042 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 522373006043 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 522373006044 Walker A/P-loop; other site 522373006045 ATP binding site [chemical binding]; other site 522373006046 Q-loop/lid; other site 522373006047 ABC transporter signature motif; other site 522373006048 Walker B; other site 522373006049 D-loop; other site 522373006050 H-loop/switch region; other site 522373006051 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373006052 FtsX-like permease family; Region: FtsX; pfam02687 522373006053 HMMPfam hit to PF02687, Predicted permease, score 9e-55 522373006054 4 probable transmembrane helices predicted for Smlt1538 by TMHMM2.0 at aa 277-299, 527-549, 576-598 and 611-633 522373006055 HMMPfam hit to PF00005, ABC transporter score 6e-55 522373006056 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373006057 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373006058 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373006059 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.4e-06 522373006060 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 0.0011 522373006061 1 probable transmembrane helix predicted for Smlt1539 by TMHMM2.0 at aa 13-32 522373006062 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373006063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373006064 active site 522373006065 phosphorylation site [posttranslational modification] 522373006066 intermolecular recognition site; other site 522373006067 dimerization interface [polypeptide binding]; other site 522373006068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373006069 DNA binding site [nucleotide binding] 522373006070 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-45 522373006071 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.5e-19 522373006072 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 522373006073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373006074 ATP binding site [chemical binding]; other site 522373006075 Mg2+ binding site [ion binding]; other site 522373006076 G-X-G motif; other site 522373006077 1 probable transmembrane helix predicted for Smlt1541 by TMHMM2.0 at aa 12-34 522373006078 HMMPfam hit to PF00672, HAMP domain, score 9.6e-15 522373006079 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 9.8e-06 522373006080 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.8e-29 522373006081 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 522373006082 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 522373006083 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373006084 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373006085 metal binding site [ion binding]; metal-binding site 522373006086 active site 522373006087 I-site; other site 522373006088 1 probable transmembrane helix predicted for Smlt1542 by TMHMM2.0 at aa 21-40 522373006089 HMMPfam hit to PF07494, Two component regulator propeller, score 0.014 522373006090 HMMPfam hit to PF07494, Two component regulator propeller, score 0.074 522373006091 HMMPfam hit to PF07494, Two component regulator propeller, score 22 522373006092 HMMPfam hit to PF07494, Two component regulator propeller, score 10 522373006093 HMMPfam hit to PF07494, Two component regulator propeller, score 0.058 522373006094 HMMPfam hit to PF07494, Two component regulator propeller, score 0.027 522373006095 HMMPfam hit to PF07494, Two component regulator propeller, score 0.63 522373006096 HMMPfam hit to PF07494, Two component regulator propeller, score 0.021 522373006097 HMMPfam hit to PF07494, Two component regulator propeller, score 0.0081 522373006098 HMMPfam hit to PF07494, Two component regulator propeller, score 0.062 522373006099 HMMPfam hit to PF07494, Two component regulator propeller, score 3.8 522373006100 HMMPfam hit to PF07494, Two component regulator propeller, score 21 522373006101 HMMPfam hit to PF07495, Y_Y_Y domain, score 1.8e-15 522373006102 HMMPfam hit to PF00990, GGDEF domain, score 3.5e-48 522373006103 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 522373006104 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 522373006105 dimer interface [polypeptide binding]; other site 522373006106 catalytic site [active] 522373006107 putative active site [active] 522373006108 putative substrate binding site [chemical binding]; other site 522373006109 HMMPfam hit to PF00929, Exonuclease, score 6.2e-22 522373006110 Predicted membrane protein [Function unknown]; Region: COG2259 522373006111 2 probable transmembrane helices predicted for Smlt1544 by TMHMM2.0 at aa 85-107 and 128-150 522373006112 HMMPfam hit to PF07681, DoxX, score 3.5e-28 522373006113 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 522373006114 hypothetical protein; Provisional; Region: PRK05409 522373006115 HMMPfam hit to PF05114, Protein of unknown function (DUF692), score 1e-154 522373006116 1 probable transmembrane helix predicted for Smlt1547 by TMHMM2.0 at aa 7-29 522373006117 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 522373006118 PhoU domain; Region: PhoU; pfam01895 522373006119 PhoU domain; Region: PhoU; pfam01895 522373006120 HMMPfam hit to PF01895, PhoU family, score 5.1e-29 522373006121 HMMPfam hit to PF01895, PhoU family, score 2.4e-22 522373006122 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 522373006123 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 522373006124 Walker A/P-loop; other site 522373006125 ATP binding site [chemical binding]; other site 522373006126 Q-loop/lid; other site 522373006127 ABC transporter signature motif; other site 522373006128 Walker B; other site 522373006129 D-loop; other site 522373006130 H-loop/switch region; other site 522373006131 HMMPfam hit to PF00005, ABC transporter score 4.6e-62 522373006132 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 522373006133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373006134 dimer interface [polypeptide binding]; other site 522373006135 conserved gate region; other site 522373006136 putative PBP binding loops; other site 522373006137 ABC-ATPase subunit interface; other site 522373006138 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.9e-24 522373006139 6 probable transmembrane helices predicted for Smlt1550 by TMHMM2.0 at aa 17-39, 70-92, 112-134, 139-158, 190-212 and 258-280 522373006140 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 522373006141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373006142 dimer interface [polypeptide binding]; other site 522373006143 conserved gate region; other site 522373006144 putative PBP binding loops; other site 522373006145 ABC-ATPase subunit interface; other site 522373006146 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 6.4e-16 522373006147 6 probable transmembrane helices predicted for Smlt1551 by TMHMM2.0 at aa 27-49, 84-106, 118-140, 172-194, 233-255 and 291-313 522373006148 PBP superfamily domain; Region: PBP_like_2; cl17296 522373006149 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 1.7e-21 522373006150 PBP superfamily domain; Region: PBP_like_2; cl17296 522373006151 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 3.4e-27 522373006152 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 522373006153 HMMPfam hit to PF07396, Phosphate-selective porin O and P, score 6.4e-131 522373006154 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 522373006155 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 522373006156 minor groove reading motif; other site 522373006157 helix-hairpin-helix signature motif; other site 522373006158 substrate binding pocket [chemical binding]; other site 522373006159 active site 522373006160 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 522373006161 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 3.5e-16 522373006162 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 1e-06 522373006163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 522373006164 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 522373006165 substrate binding site [chemical binding]; other site 522373006166 oxyanion hole (OAH) forming residues; other site 522373006167 trimer interface [polypeptide binding]; other site 522373006168 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 1.2e-67 522373006169 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 522373006170 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 522373006171 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 522373006172 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 5.4e-26 522373006173 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 6.2e-05 522373006174 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 522373006175 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 522373006176 putative active site [active] 522373006177 putative CoA binding site [chemical binding]; other site 522373006178 nudix motif; other site 522373006179 metal binding site [ion binding]; metal-binding site 522373006180 HMMPfam hit to PF06945, Protein of unknown function (DUF1289), score 1.9e-13 522373006181 HMMPfam hit to PF00293, NUDIX domain, score 1.6e-12 522373006182 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 522373006183 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 522373006184 active site residue [active] 522373006185 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 522373006186 active site residue [active] 522373006187 HMMPfam hit to PF00581, Rhodanese-like domain, score 3.1e-11 522373006188 HMMPfam hit to PF00581, Rhodanese-like domain, score 2.2e-06 522373006189 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 522373006190 amidase catalytic site [active] 522373006191 Zn binding residues [ion binding]; other site 522373006192 substrate binding site [chemical binding]; other site 522373006193 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 2.8e-15 522373006194 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 522373006195 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 522373006196 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 522373006197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 522373006198 HMMPfam hit to PF02926, THUMP domain, score 4.6e-10 522373006199 HMMPfam hit to PF01170, Putative RNA methylase family UPF0020, score 1.8e-48 522373006200 HMMPfam hit to PF03602, Conserved hypothetical protein, score 0.0019 522373006201 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 522373006202 3 probable transmembrane helices predicted for Smlt1565 by TMHMM2.0 at aa 41-58, 62-84 and 91-108 522373006203 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 522373006204 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 522373006205 8 probable transmembrane helices predicted for Smlt1566 by TMHMM2.0 at aa 12-34, 146-168, 200-222, 348-370, 391-410, 425-442, 449-471 and 486-505 522373006206 HMMPfam hit to PF03929, PepSY-associated TM helix, score 1.3 522373006207 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.31 522373006208 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.0025 522373006209 3 probable transmembrane helices predicted for Smlt1567 by TMHMM2.0 at aa 53-75, 80-102 and 107-129 522373006210 Protein of unknown function (DUF445); Region: DUF445; pfam04286 522373006211 HMMPfam hit to PF04286, Protein of unknown function (DUF445), score 2e-124 522373006212 3 probable transmembrane helices predicted for Smlt1568 by TMHMM2.0 at aa 17-36, 41-63 and 403-425 522373006213 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 522373006214 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 522373006215 inhibitor-cofactor binding pocket; inhibition site 522373006216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373006217 catalytic residue [active] 522373006218 HMMPfam hit to PF00202, Aminotransferase class-III, score 4.7e-129 522373006219 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 522373006220 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 522373006221 NAD(P) binding site [chemical binding]; other site 522373006222 catalytic residues [active] 522373006223 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.3e-237 522373006224 1 probable transmembrane helix predicted for Smlt1572 by TMHMM2.0 at aa 22-40 522373006225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373006226 metabolite-proton symporter; Region: 2A0106; TIGR00883 522373006227 putative substrate translocation pore; other site 522373006228 HMMPfam hit to PF00083, Sugar (and other) transporter score 9.8e-13 522373006229 12 probable transmembrane helices predicted for Smlt1573 by TMHMM2.0 at aa 47-69, 84-106, 119-141, 151-173, 186-208, 218-240, 272-294, 309-328, 340-357, 367-389, 402-424 and 428-450 522373006230 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-22 522373006231 Hemerythrin; Region: Hemerythrin; cd12107 522373006232 Fe binding site [ion binding]; other site 522373006233 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 0.00021 522373006234 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 8.7e-07 522373006235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 522373006236 active site 522373006237 phosphorylation site [posttranslational modification] 522373006238 intermolecular recognition site; other site 522373006239 dimerization interface [polypeptide binding]; other site 522373006240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373006241 Response regulator receiver domain; Region: Response_reg; pfam00072 522373006242 active site 522373006243 phosphorylation site [posttranslational modification] 522373006244 intermolecular recognition site; other site 522373006245 dimerization interface [polypeptide binding]; other site 522373006246 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373006247 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373006248 metal binding site [ion binding]; metal-binding site 522373006249 active site 522373006250 I-site; other site 522373006251 HMMPfam hit to PF00990, GGDEF domain, score 1.5e-55 522373006252 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-24 522373006253 MASE1; Region: MASE1; cl17823 522373006254 5 probable transmembrane helices predicted for Smlt1576 by TMHMM2.0 at aa 118-140, 152-174, 194-211, 224-246 and 256-273 522373006255 MASE1; Region: MASE1; cl17823 522373006256 9 probable transmembrane helices predicted for Smlt1577 by TMHMM2.0 at aa 10-32, 39-61, 81-103, 116-138, 151-173, 180-202, 212-234, 236-253 and 263-285 522373006257 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 522373006258 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 522373006259 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.9e-89 522373006260 Peptidase C26; Region: Peptidase_C26; pfam07722 522373006261 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 522373006262 catalytic triad [active] 522373006263 HMMPfam hit to PF07722, Peptidase C26, score 2.5e-92 522373006264 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 0.0053 522373006265 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 522373006266 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 522373006267 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 522373006268 HMMPfam hit to PF00120, Glutamine synthetase, catalytic domain, score 2.3e-106 522373006269 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 522373006270 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 522373006271 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 1.3e-17 522373006272 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 522373006273 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373006274 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 0.002 522373006275 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 522373006276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373006277 Walker A/P-loop; other site 522373006278 ATP binding site [chemical binding]; other site 522373006279 Q-loop/lid; other site 522373006280 ABC transporter signature motif; other site 522373006281 Walker B; other site 522373006282 D-loop; other site 522373006283 H-loop/switch region; other site 522373006284 TOBE domain; Region: TOBE_2; pfam08402 522373006285 HMMPfam hit to PF00005, ABC transporter score 3.3e-63 522373006286 HMMPfam hit to PF08402, TOBE domain, score 1.1e-24 522373006287 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 522373006288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373006289 dimer interface [polypeptide binding]; other site 522373006290 conserved gate region; other site 522373006291 putative PBP binding loops; other site 522373006292 ABC-ATPase subunit interface; other site 522373006293 6 probable transmembrane helices predicted for Smlt1585 by TMHMM2.0 at aa 21-43, 88-110, 117-139, 178-200, 220-242 and 276-298 522373006294 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 6.7e-16 522373006295 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 522373006296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373006297 dimer interface [polypeptide binding]; other site 522373006298 conserved gate region; other site 522373006299 putative PBP binding loops; other site 522373006300 ABC-ATPase subunit interface; other site 522373006301 6 probable transmembrane helices predicted for Smlt1586 by TMHMM2.0 at aa 9-31, 65-87, 100-122, 137-159, 180-202 and 239-261 522373006302 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.3e-06 522373006303 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 522373006304 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 522373006305 NAD(P) binding site [chemical binding]; other site 522373006306 catalytic residues [active] 522373006307 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 9.1e-145 522373006308 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 522373006309 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 522373006310 oligomer interface [polypeptide binding]; other site 522373006311 metal binding site [ion binding]; metal-binding site 522373006312 metal binding site [ion binding]; metal-binding site 522373006313 putative Cl binding site [ion binding]; other site 522373006314 basic sphincter; other site 522373006315 hydrophobic gate; other site 522373006316 periplasmic entrance; other site 522373006317 HMMPfam hit to PF01544, CorA-like Mg2+ transporter protein, score 5.2e-49 522373006318 2 probable transmembrane helices predicted for Smlt1589 by TMHMM2.0 at aa 283-302 and 317-334 522373006319 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 522373006320 6 probable transmembrane helices predicted for Smlt1590 by TMHMM2.0 at aa 5-27, 273-290, 297-319, 334-351, 363-382 and 386-405 522373006321 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 522373006322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 522373006323 Transporter associated domain; Region: CorC_HlyC; smart01091 522373006324 HMMPfam hit to PF03471, Transporter associated domain, score 2.3e-19 522373006325 HMMPfam hit to PF00571, CBS domain pair, score 1.4e-25 522373006326 5 probable transmembrane helices predicted for Smlt1593 by TMHMM2.0 at aa 10-28, 41-63, 83-102, 123-142 and 162-181 522373006327 metal-binding heat shock protein; Provisional; Region: PRK00016 522373006328 HMMPfam hit to PF02130, Uncharacterized protein family UPF0054, score 5.7e-48 522373006329 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 522373006330 PhoH-like protein; Region: PhoH; pfam02562 522373006331 HMMPfam hit to PF02562, PhoH-like protein, score 1.7e-139 522373006332 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373006333 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373006334 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.3e-05 522373006335 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 522373006336 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 522373006337 Walker A/P-loop; other site 522373006338 ATP binding site [chemical binding]; other site 522373006339 Q-loop/lid; other site 522373006340 ABC transporter signature motif; other site 522373006341 Walker B; other site 522373006342 D-loop; other site 522373006343 H-loop/switch region; other site 522373006344 HMMPfam hit to PF00005, ABC transporter score 3.3e-62 522373006345 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 522373006346 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 522373006347 6 probable transmembrane helices predicted for Smlt1599 by TMHMM2.0 at aa 21-43, 177-199, 225-247, 257-276, 289-311 and 343-365 522373006348 HMMPfam hit to PF01061, ABC-2 type transporter score 1.2e-32 522373006349 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 522373006350 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 522373006351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373006352 FeS/SAM binding site; other site 522373006353 TRAM domain; Region: TRAM; pfam01938 522373006354 HMMPfam hit to PF01938, TRAM domain, score 1.3e-19 522373006355 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.3e-32 522373006356 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 2.6e-43 522373006357 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 522373006358 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 522373006359 putative C-terminal domain interface [polypeptide binding]; other site 522373006360 putative GSH binding site (G-site) [chemical binding]; other site 522373006361 putative dimer interface [polypeptide binding]; other site 522373006362 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 522373006363 dimer interface [polypeptide binding]; other site 522373006364 N-terminal domain interface [polypeptide binding]; other site 522373006365 putative substrate binding pocket (H-site) [chemical binding]; other site 522373006366 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 4.2e-10 522373006367 WYL domain; Region: WYL; pfam13280 522373006368 HMMPfam hit to PF02082, Transcriptional regulator, score 2e-06 522373006369 HMMPfam hit to PF08279, HTH domain, score 4.1e-21 522373006370 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 522373006371 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 522373006372 N-acetyl-D-glucosamine binding site [chemical binding]; other site 522373006373 catalytic residue [active] 522373006374 1 probable transmembrane helix predicted for Smlt1603 by TMHMM2.0 at aa 15-37 522373006375 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 5.3e-31 522373006376 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 522373006377 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 522373006378 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 522373006379 [2Fe-2S] cluster binding site [ion binding]; other site 522373006380 1 probable transmembrane helix predicted for Smlt1604 by TMHMM2.0 at aa 16-38 522373006381 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain, score 3.5e-05 522373006382 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 522373006383 Qi binding site; other site 522373006384 intrachain domain interface; other site 522373006385 interchain domain interface [polypeptide binding]; other site 522373006386 cytochrome b; Provisional; Region: CYTB; MTH00156 522373006387 heme bH binding site [chemical binding]; other site 522373006388 heme bL binding site [chemical binding]; other site 522373006389 Qo binding site; other site 522373006390 interchain domain interface [polypeptide binding]; other site 522373006391 intrachain domain interface; other site 522373006392 Qi binding site; other site 522373006393 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 522373006394 Qo binding site; other site 522373006395 HMMPfam hit to PF00033, Cytochrome b(N-terminal)/b6/petB, score 7e-88 522373006396 9 probable transmembrane helices predicted for Smlt1605 by TMHMM2.0 at aa 42-64, 89-111, 126-148, 160-179, 194-216, 261-283, 320-339, 351-373 and 383-405 522373006397 HMMPfam hit to PF00032, Cytochrome b(C-terminal)/b6/petD, score 3.9e-16 522373006398 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 522373006399 HMMPfam hit to PF02167, Cytochrome C1 family, score 6.4e-11 522373006400 1 probable transmembrane helix predicted for Smlt1606 by TMHMM2.0 at aa 221-240 522373006401 stringent starvation protein A; Provisional; Region: sspA; PRK09481 522373006402 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 522373006403 C-terminal domain interface [polypeptide binding]; other site 522373006404 putative GSH binding site (G-site) [chemical binding]; other site 522373006405 dimer interface [polypeptide binding]; other site 522373006406 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 522373006407 dimer interface [polypeptide binding]; other site 522373006408 N-terminal domain interface [polypeptide binding]; other site 522373006409 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 4.4e-13 522373006410 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 5.5e-06 522373006411 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 522373006412 HMMPfam hit to PF04386, Stringent starvation protein B, score 2.6e-72 522373006413 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 522373006414 1 probable transmembrane helix predicted for Smlt1609 by TMHMM2.0 at aa 10-29 522373006415 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030 522373006416 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 522373006417 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 522373006418 dimerization interface [polypeptide binding]; other site 522373006419 active site 522373006420 HMMPfam hit to PF01729, Quinolinate phosphoribosyl transferase, C-t, score 1.5e-76 522373006421 HMMPfam hit to PF02749, Quinolinate phosphoribosyl transferase, N-t, score 4.1e-31 522373006422 Trm112p-like protein; Region: Trm112p; cl01066 522373006423 HMMPfam hit to PF03966, Trm112p-like protein, score 9.9e-11 522373006424 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 522373006425 HMMPfam hit to PF00731, AIR carboxylase, score 6e-83 522373006426 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 522373006427 ATP-grasp domain; Region: ATP-grasp; pfam02222 522373006428 HMMPfam hit to PF02222, ATP-grasp domain, score 2.3e-86 522373006429 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 522373006430 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 2.3e-23 522373006431 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 522373006432 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 522373006433 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 522373006434 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 4.1e-56 522373006435 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 6.5e-30 522373006436 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 522373006437 putative GSH binding site [chemical binding]; other site 522373006438 catalytic residues [active] 522373006439 HMMPfam hit to PF00462, Glutaredoxin, score 2.1e-23 522373006440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373006441 NAD(P) binding site [chemical binding]; other site 522373006442 active site 522373006443 HMMPfam hit to PF00106, short chain dehydrogenase, score 9.8e-08 522373006444 1 probable transmembrane helix predicted for Smlt1618 by TMHMM2.0 at aa 30-52 522373006445 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 522373006446 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373006447 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373006448 HMMPfam hit to PF05738, no description, score 0.01 522373006449 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 522373006450 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 522373006451 HMMPfam hit to PF03641, Possible lysine decarboxylase, score 1.3e-44 522373006452 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 522373006453 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 522373006454 Type II transport protein GspH; Region: GspH; pfam12019 522373006455 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 1e-06 522373006456 1 probable transmembrane helix predicted for Smlt1621 by TMHMM2.0 at aa 10-32 522373006457 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 522373006458 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 0.0048 522373006459 1 probable transmembrane helix predicted for Smlt1622 by TMHMM2.0 at aa 17-39 522373006460 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 522373006461 1 probable transmembrane helix predicted for Smlt1623 by TMHMM2.0 at aa 12-34 522373006462 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 522373006463 PilX N-terminal; Region: PilX_N; pfam14341 522373006464 1 probable transmembrane helix predicted for Smlt1624 by TMHMM2.0 at aa 20-42 522373006465 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 522373006466 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 522373006467 1 probable transmembrane helix predicted for Smlt1625 by TMHMM2.0 at aa 13-35 522373006468 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 522373006469 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 7.2e-08 522373006470 1 probable transmembrane helix predicted for Smlt1626 by TMHMM2.0 at aa 21-43 522373006471 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 522373006472 Type II transport protein GspH; Region: GspH; pfam12019 522373006473 1 probable transmembrane helix predicted for Smlt1627 by TMHMM2.0 at aa 7-29 522373006474 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 0.005 522373006475 excinuclease ABC subunit B; Provisional; Region: PRK05298 522373006476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373006477 ATP binding site [chemical binding]; other site 522373006478 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373006479 nucleotide binding region [chemical binding]; other site 522373006480 ATP-binding site [chemical binding]; other site 522373006481 Ultra-violet resistance protein B; Region: UvrB; pfam12344 522373006482 UvrB/uvrC motif; Region: UVR; pfam02151 522373006483 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.5e-19 522373006484 HMMPfam hit to PF02151, UvrB/uvrC motif, score 5e-12 522373006485 1 probable transmembrane helix predicted for Smlt1630 by TMHMM2.0 at aa 38-60 522373006486 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 522373006487 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373006488 catalytic residues [active] 522373006489 HMMPfam hit to PF08534, Redoxin, score 0.00027 522373006490 1 probable transmembrane helix predicted for Smlt1631 by TMHMM2.0 at aa 5-24 522373006491 conserved hypothetical protein, pseudogene;Similar to N-terminus of Archaeoglobus fulgidus. hypothetical protein. UniProt:O28967 (EMBL:AE000782 (188 aa) fasta scores: E()=6.3, 34.783% id in 46 aa; similarity:fasta; with=UniProt:O28967 (EMBL:AE000782;); Archaeoglobus fulgidus.; Hypothetical protein.; length=188; id 34.783%; ungapped id 35.556%; E()=6.3; 46 aa overlap; query 8-53; subject 8-52 522373006492 1 probable transmembrane helix predicted for Smlt1632 by TMHMM2.0 at aa 42-64 522373006493 MltA-interacting protein MipA; Region: MipA; cl01504 522373006494 HMMPfam hit to PF06629, MltA-interacting protein MipA, score 2.8e-26 522373006495 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373006496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373006497 active site 522373006498 phosphorylation site [posttranslational modification] 522373006499 intermolecular recognition site; other site 522373006500 dimerization interface [polypeptide binding]; other site 522373006501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373006502 DNA binding site [nucleotide binding] 522373006503 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.8e-05 522373006504 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1e-18 522373006505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373006506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373006507 dimer interface [polypeptide binding]; other site 522373006508 phosphorylation site [posttranslational modification] 522373006509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373006510 Mg2+ binding site [ion binding]; other site 522373006511 G-X-G motif; other site 522373006512 2 probable transmembrane helices predicted for Smlt1636 by TMHMM2.0 at aa 13-35 and 161-183 522373006513 HMMPfam hit to PF00672, HAMP domain, score 0.0015 522373006514 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.2e-07 522373006515 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1e-29 522373006516 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 522373006517 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 522373006518 Competence protein; Region: Competence; pfam03772 522373006519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 522373006520 7 probable transmembrane helices predicted for Smlt1637 by TMHMM2.0 at aa 7-26, 31-53, 257-279, 294-328, 341-363, 389-411 and 423-445 522373006521 HMMPfam hit to PF03772, Competence protein, score 3.4e-61 522373006522 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.7e-07 522373006523 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 522373006524 3 probable transmembrane helices predicted for Smlt1638 by TMHMM2.0 at aa 10-27, 110-132 and 147-169 522373006525 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 8.8e-26 522373006526 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 522373006527 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 522373006528 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 9.3e-26 522373006529 1 probable transmembrane helix predicted for Smlt1639 by TMHMM2.0 at aa 13-35 522373006530 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 522373006531 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 522373006532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373006533 Walker A/P-loop; other site 522373006534 ATP binding site [chemical binding]; other site 522373006535 Q-loop/lid; other site 522373006536 ABC transporter signature motif; other site 522373006537 Walker B; other site 522373006538 D-loop; other site 522373006539 H-loop/switch region; other site 522373006540 5 probable transmembrane helices predicted for Smlt1640 by TMHMM2.0 at aa 21-43, 63-80, 145-162, 166-185 and 248-270 522373006541 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 1.3e-32 522373006542 HMMPfam hit to PF00005, ABC transporter score 7.5e-64 522373006543 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 522373006544 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 522373006545 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 2.2e-76 522373006546 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 522373006547 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 522373006548 Ligand binding site; other site 522373006549 oligomer interface; other site 522373006550 HMMPfam hit to PF02348, Cytidylyltransferase, score 5.1e-55 522373006551 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 522373006552 Low molecular weight phosphatase family; Region: LMWPc; cd00115 522373006553 active site 522373006554 HMMPfam hit to PF01451, Low molecular weight phosphotyrosine protein, score 1.1e-41 522373006555 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 522373006556 NHL repeat; Region: NHL; pfam01436 522373006557 HMMPfam hit to PF01436, NHL repeat, score 9.8e-06 522373006558 HMMPfam hit to PF01436, NHL repeat, score 0.00085 522373006559 HMMPfam hit to PF01436, NHL repeat, score 0.074 522373006560 HMMPfam hit to PF01436, NHL repeat, score 1.2 522373006561 HMMPfam hit to PF01436, NHL repeat, score 0.0029 522373006562 HMMPfam hit to PF01436, NHL repeat, score 0.0012 522373006563 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 522373006564 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 522373006565 GIY-YIG motif/motif A; other site 522373006566 active site 522373006567 catalytic site [active] 522373006568 putative DNA binding site [nucleotide binding]; other site 522373006569 metal binding site [ion binding]; metal-binding site 522373006570 UvrB/uvrC motif; Region: UVR; pfam02151 522373006571 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 522373006572 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 2.2e-26 522373006573 HMMPfam hit to PF02151, UvrB/uvrC motif, score 2e-10 522373006574 HMMPfam hit to PF08459, UvrC Helix-hairpin-helix N-terminal, score 3.5e-85 522373006575 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 522373006576 4 probable transmembrane helices predicted for Smlt1646 by TMHMM2.0 at aa 9-31, 75-97, 136-158 and 168-190 522373006577 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 2.1e-40 522373006578 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 522373006579 HMMPfam hit to PF01494, FAD binding domain, score 5.1e-07 522373006580 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 522373006581 HMMPfam hit to PF02321, Outer membrane efflux protein, score 6.2e-07 522373006582 HMMPfam hit to PF02321, Outer membrane efflux protein, score 8.2e-28 522373006583 FtsX-like permease family; Region: FtsX; pfam02687 522373006584 4 probable transmembrane helices predicted for Smlt1652 by TMHMM2.0 at aa 20-42, 255-274, 311-333 and 346-368 522373006585 HMMPfam hit to PF02687, Predicted permease, score 1.9e-15 522373006586 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 522373006587 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 522373006588 Walker A/P-loop; other site 522373006589 ATP binding site [chemical binding]; other site 522373006590 Q-loop/lid; other site 522373006591 ABC transporter signature motif; other site 522373006592 Walker B; other site 522373006593 D-loop; other site 522373006594 H-loop/switch region; other site 522373006595 HMMPfam hit to PF00005, ABC transporter score 3.8e-64 522373006596 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373006597 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373006598 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.0011 522373006599 4 probable transmembrane helices predicted for Smlt1655 by TMHMM2.0 at aa 9-31, 46-68, 77-99 and 109-131 522373006600 4 probable transmembrane helices predicted for Smlt1656 by TMHMM2.0 at aa 7-26, 46-68, 75-92 and 97-119 522373006601 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 522373006602 1 probable transmembrane helix predicted for Smlt1661 by TMHMM2.0 at aa 22-41 522373006603 putative transposase OrfB; Reviewed; Region: PHA02517 522373006604 HTH-like domain; Region: HTH_21; pfam13276 522373006605 Integrase core domain; Region: rve; pfam00665 522373006606 Integrase core domain; Region: rve_2; pfam13333 522373006607 HMMPfam hit to PF00665, Integrase core domain, score 9e-51 522373006608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373006609 Transposase; Region: HTH_Tnp_1; pfam01527 522373006610 HMMPfam hit to PF01527, Transposase, score 1.1e-21 522373006611 4 probable transmembrane helices predicted for Smlt1664 by TMHMM2.0 at aa 5-22, 32-54, 74-96 and 111-133 522373006612 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 522373006613 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 522373006614 nudix motif; other site 522373006615 HMMPfam hit to PF00293, NUDIX domain, score 2.4e-23 522373006616 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 522373006617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373006618 Coenzyme A binding pocket [chemical binding]; other site 522373006619 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3e-22 522373006620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373006621 Coenzyme A binding pocket [chemical binding]; other site 522373006622 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.5e-08 522373006623 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 522373006624 Flavin Reductases; Region: FlaRed; cl00801 522373006625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373006626 dimerization interface [polypeptide binding]; other site 522373006627 putative DNA binding site [nucleotide binding]; other site 522373006628 putative Zn2+ binding site [ion binding]; other site 522373006629 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 0.0018 522373006630 Prolyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ProS; COG0442 522373006631 AAA domain; Region: AAA_33; pfam13671 522373006632 AAA domain; Region: AAA_17; pfam13207 522373006633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373006634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373006635 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 522373006636 dimerization interface [polypeptide binding]; other site 522373006637 substrate binding pocket [chemical binding]; other site 522373006638 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.4e-44 522373006639 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.7e-21 522373006640 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 522373006641 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 522373006642 active site 522373006643 catalytic tetrad [active] 522373006644 HMMPfam hit to PF00248, Aldo/keto reductase family, score 4.5e-16 522373006645 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 522373006646 putative hydrophobic ligand binding site [chemical binding]; other site 522373006647 protein interface [polypeptide binding]; other site 522373006648 gate; other site 522373006649 Cupin; Region: Cupin_6; pfam12852 522373006650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373006651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 522373006652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373006653 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 8.8e-08 522373006654 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.6e-08 522373006655 camphor resistance protein CrcB; Provisional; Region: PRK14198 522373006656 4 probable transmembrane helices predicted for Smlt1683 by TMHMM2.0 at aa 40-62, 72-91, 104-126 and 136-158 522373006657 HMMPfam hit to PF02537, CrcB-like protein, score 2e-28 522373006658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373006659 non-specific DNA binding site [nucleotide binding]; other site 522373006660 salt bridge; other site 522373006661 sequence-specific DNA binding site [nucleotide binding]; other site 522373006662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 522373006663 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 522373006664 5 probable transmembrane helices predicted for Smlt1687 by TMHMM2.0 at aa 13-32, 59-81, 120-142, 152-174 and 329-346 522373006665 2 probable transmembrane helices predicted for Smlt1688 by TMHMM2.0 at aa 16-38 and 58-80 522373006666 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 522373006667 apolar tunnel; other site 522373006668 heme binding site [chemical binding]; other site 522373006669 dimerization interface [polypeptide binding]; other site 522373006670 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 522373006671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373006672 FeS/SAM binding site; other site 522373006673 HemN C-terminal domain; Region: HemN_C; pfam06969 522373006674 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.4e-25 522373006675 HMMPfam hit to PF06969, HemN C-terminal region, score 2.6e-52 522373006676 Sensors of blue-light using FAD; Region: BLUF; pfam04940 522373006677 HMMPfam hit to PF04940, Sensors of blue-light using FAD, score 2e-14 522373006678 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 522373006679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373006680 NAD(P) binding site [chemical binding]; other site 522373006681 active site 522373006682 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 522373006683 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 522373006684 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 4.2e-59 522373006685 1 probable transmembrane helix predicted for Smlt1692 by TMHMM2.0 at aa 13-35 522373006686 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 1.2e-35 522373006687 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 7.7e-20 522373006688 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 522373006689 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 522373006690 active site 522373006691 FMN binding site [chemical binding]; other site 522373006692 substrate binding site [chemical binding]; other site 522373006693 3Fe-4S cluster binding site [ion binding]; other site 522373006694 1 probable transmembrane helix predicted for Smlt1693 by TMHMM2.0 at aa 12-34 522373006695 HMMPfam hit to PF01645, Conserved region in glutamate synthase, score 8.5e-85 522373006696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 522373006697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373006698 Coenzyme A binding pocket [chemical binding]; other site 522373006699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 522373006700 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.6e-09 522373006701 hypothetical protein; Provisional; Region: PRK07236 522373006702 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 522373006703 HMMPfam hit to PF03486, HI0933-like protein, score 8.9e-134 522373006704 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 0.00064 522373006705 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0012 522373006706 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 522373006707 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 2e-46 522373006708 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 522373006709 1 probable transmembrane helix predicted for Smlt1697 by TMHMM2.0 at aa 96-118 522373006710 rhodanese superfamily protein; Provisional; Region: PRK05320 522373006711 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 522373006712 active site residue [active] 522373006713 HMMPfam hit to PF00581, Rhodanese-like domain, score 1.7e-05 522373006714 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 522373006715 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 522373006716 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 1.3e-15 522373006717 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 522373006718 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 5.2e-13 522373006719 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 522373006720 4 probable transmembrane helices predicted for Smlt1703 by TMHMM2.0 at aa 61-83, 132-154, 158-180 and 187-209 522373006721 HMMPfam hit to PF06055, Exopolysaccharide synthesis, ExoD, score 1.2e-49 522373006722 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 522373006723 Domain of unknown function DUF21; Region: DUF21; pfam01595 522373006724 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 522373006725 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 522373006726 Transporter associated domain; Region: CorC_HlyC; smart01091 522373006727 HMMPfam hit to PF03471, Transporter associated domain, score 8.8e-18 522373006728 HMMPfam hit to PF00571, CBS domain pair, score 1.9e-22 522373006729 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 4.3e-76 522373006730 4 probable transmembrane helices predicted for Smlt1704 by TMHMM2.0 at aa 4-26, 66-88, 98-120 and 132-154 522373006731 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 522373006732 Phosphate transporter family; Region: PHO4; pfam01384 522373006733 7 probable transmembrane helices predicted for Smlt1706 by TMHMM2.0 at aa 2-21, 41-63, 76-95, 155-177, 190-209, 254-276 and 345-364 522373006734 HMMPfam hit to PF01384, Phosphate transporter family, score 4.6e-66 522373006735 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 522373006736 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 522373006737 HMMPfam hit to PF00450, Serine carboxypeptidase, score 3.3e-12 522373006738 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 522373006739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 522373006740 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.4e-09 522373006741 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 522373006742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373006743 Mg2+ binding site [ion binding]; other site 522373006744 G-X-G motif; other site 522373006745 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 522373006746 anchoring element; other site 522373006747 dimer interface [polypeptide binding]; other site 522373006748 ATP binding site [chemical binding]; other site 522373006749 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 522373006750 active site 522373006751 metal binding site [ion binding]; metal-binding site 522373006752 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 522373006753 HMMPfam hit to PF00986, DNA gyrase B subunit, carboxyl terminus, score 5.2e-22 522373006754 HMMPfam hit to PF00204, DNA gyrase B, score 6.8e-46 522373006755 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 1.3e-27 522373006756 1 probable transmembrane helix predicted for Smlt1710 by TMHMM2.0 at aa 111-133 522373006757 CTP synthetase; Validated; Region: pyrG; PRK05380 522373006758 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 522373006759 Catalytic site [active] 522373006760 active site 522373006761 UTP binding site [chemical binding]; other site 522373006762 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 522373006763 active site 522373006764 putative oxyanion hole; other site 522373006765 catalytic triad [active] 522373006766 HMMPfam hit to PF06418, CTP synthase N-terminus, score 3.6e-206 522373006767 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 7.5e-63 522373006768 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 522373006769 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 522373006770 HMMPfam hit to PF00793, DAHP synthetase I family, score 3.2e-105 522373006771 3 probable transmembrane helices predicted for Smlt1713 by TMHMM2.0 at aa 21-43, 63-85 and 92-114 522373006772 3 probable transmembrane helices predicted for Smlt1714 by TMHMM2.0 at aa 13-35, 55-77 and 84-106 522373006773 enolase; Provisional; Region: eno; PRK00077 522373006774 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 522373006775 dimer interface [polypeptide binding]; other site 522373006776 metal binding site [ion binding]; metal-binding site 522373006777 substrate binding pocket [chemical binding]; other site 522373006778 HMMPfam hit to PF03952, Enolase, N-terminal domain, score 4.5e-63 522373006779 HMMPfam hit to PF00113, Enolase, C-terminal TIM barrel domain, score 3.4e-172 522373006780 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 522373006781 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 522373006782 1 probable transmembrane helix predicted for Smlt1716 by TMHMM2.0 at aa 7-24 522373006783 HMMPfam hit to PF04977, Septum formation initiator, score 1.1e-33 522373006784 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 522373006785 substrate binding site; other site 522373006786 dimer interface; other site 522373006787 HMMPfam hit to PF01128, Uncharacterized protein family UPF0007, score 7.2e-73 522373006788 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 522373006789 homotrimer interaction site [polypeptide binding]; other site 522373006790 zinc binding site [ion binding]; other site 522373006791 CDP-binding sites; other site 522373006792 HMMPfam hit to PF02542, YgbB family, score 4.2e-78 522373006793 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 522373006794 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 522373006795 Permutation of conserved domain; other site 522373006796 active site 522373006797 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 522373006798 HMMPfam hit to PF01142, tRNA pseudouridine synthase D (TruD), score 5.5e-126 522373006799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 522373006800 Smr domain; Region: Smr; pfam01713 522373006801 HMMPfam hit to PF01713, Smr domain, score 4.4e-32 522373006802 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 522373006803 HMMPfam hit to PF01975, Survival protein SurE, score 1e-83 522373006804 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 522373006805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373006806 S-adenosylmethionine binding site [chemical binding]; other site 522373006807 HMMPfam hit to PF01135, Protein-L-isoaspartate(D-aspartate) O, score 4.9e-60 522373006808 HMMPfam hit to PF08241, Methyltransferase domain, score 0.0017 522373006809 Predicted membrane protein [Function unknown]; Region: COG1238 522373006810 4 probable transmembrane helices predicted for Smlt1723 by TMHMM2.0 at aa 20-39, 54-76, 112-134 and 182-199 522373006811 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 522373006812 Peptidase family M23; Region: Peptidase_M23; pfam01551 522373006813 HMMPfam hit to PF01476, LysM domain, score 1.6e-13 522373006814 HMMPfam hit to PF01551, Peptidase family M23, score 2.6e-43 522373006815 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 522373006816 HMMPfam hit to PF04430, Protein of unknown function (DUF498/DUF598), score 2.1e-35 522373006817 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 522373006818 HMMPfam hit to PF01985, CRS1 / YhbY domain, score 6.3e-31 522373006819 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 522373006820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373006821 S-adenosylmethionine binding site [chemical binding]; other site 522373006822 HMMPfam hit to PF01728, FtsJ-like methyltransferase, score 2.1e-59 522373006823 FtsH Extracellular; Region: FtsH_ext; pfam06480 522373006824 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 522373006825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373006826 Walker A motif; other site 522373006827 ATP binding site [chemical binding]; other site 522373006828 Walker B motif; other site 522373006829 arginine finger; other site 522373006830 Peptidase family M41; Region: Peptidase_M41; pfam01434 522373006831 2 probable transmembrane helices predicted for Smlt1729 by TMHMM2.0 at aa 10-27 and 109-131 522373006832 HMMPfam hit to PF06480, FtsH Extracellular, score 2.7e-43 522373006833 HMMPfam hit to PF00004, ATPase family associated with various c, score 1.9e-102 522373006834 HMMPfam hit to PF07728, ATPase family associated with various c, score 0.00027 522373006835 HMMPfam hit to PF01434, Peptidase family M41, score 2.5e-126 522373006836 1 probable transmembrane helix predicted for Smlt1730 by TMHMM2.0 at aa 15-49 522373006837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373006838 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373006839 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373006840 HMMPfam hit to PF01548, Transposase, score 1.8e-06 522373006841 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 4.3e-27 522373006842 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 522373006843 dihydropteroate synthase; Region: DHPS; TIGR01496 522373006844 substrate binding pocket [chemical binding]; other site 522373006845 dimer interface [polypeptide binding]; other site 522373006846 inhibitor binding site; inhibition site 522373006847 HMMPfam hit to PF00809, Pterin binding enzyme, score 9.1e-94 522373006848 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 522373006849 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 522373006850 active site 522373006851 HMMPfam hit to PF01715, IPP transferase, score 6.4e-112 522373006852 bacterial Hfq-like; Region: Hfq; cd01716 522373006853 hexamer interface [polypeptide binding]; other site 522373006854 Sm1 motif; other site 522373006855 RNA binding site [nucleotide binding]; other site 522373006856 Sm2 motif; other site 522373006857 HMMPfam hit to PF01423, LSM domain, score 4.3e-14 522373006858 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 522373006859 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 522373006860 HflX GTPase family; Region: HflX; cd01878 522373006861 G1 box; other site 522373006862 GTP/Mg2+ binding site [chemical binding]; other site 522373006863 Switch I region; other site 522373006864 G2 box; other site 522373006865 G3 box; other site 522373006866 Switch II region; other site 522373006867 G4 box; other site 522373006868 G5 box; other site 522373006869 HMMPfam hit to PF01926, GTPase of unknown function, score 4.1e-43 522373006870 Competence-damaged protein; Region: CinA; cl00666 522373006871 HMMPfam hit to PF02464, Competence-damaged protein, score 8.1e-62 522373006872 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 522373006873 ABC1 family; Region: ABC1; cl17513 522373006874 HMMPfam hit to PF03109, ABC1 family, score 5.3e-48 522373006875 2 probable transmembrane helices predicted for Smlt1739 by TMHMM2.0 at aa 504-526 and 533-555 522373006876 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 522373006877 LexA repressor; Validated; Region: PRK00215 522373006878 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 522373006879 Catalytic site [active] 522373006880 HMMPfam hit to PF01726, LexA DNA binding domain, score 2.6e-21 522373006881 HMMPfam hit to PF00717, Peptidase S24-like, score 2.7e-22 522373006882 recombinase A; Provisional; Region: recA; PRK09354 522373006883 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 522373006884 hexamer interface [polypeptide binding]; other site 522373006885 Walker A motif; other site 522373006886 ATP binding site [chemical binding]; other site 522373006887 Walker B motif; other site 522373006888 HMMPfam hit to PF00154, recA bacterial DNA recombination protein, score 8.5e-236 522373006889 recombination regulator RecX; Reviewed; Region: recX; PRK00117 522373006890 HMMPfam hit to PF02631, RecX family, score 2.7e-15 522373006891 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 522373006892 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 522373006893 motif 1; other site 522373006894 active site 522373006895 motif 2; other site 522373006896 motif 3; other site 522373006897 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 522373006898 DHHA1 domain; Region: DHHA1; pfam02272 522373006899 HMMPfam hit to PF01411, tRNA synthetases class II (A), score 0 522373006900 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase seco, score 1.1e-22 522373006901 HMMPfam hit to PF02272, DHHA1 domain, score 8.9e-18 522373006902 carbon storage regulator; Provisional; Region: PRK01712 522373006903 HMMPfam hit to PF02599, Global regulator protein family, score 4.4e-30 522373006904 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373006905 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 522373006906 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373006907 HMMPfam hit to PF00593, TonB dependent receptor, score 9.3e-26 522373006908 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.5e-14 522373006909 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 522373006910 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 522373006911 dimer interface [polypeptide binding]; other site 522373006912 TPP-binding site [chemical binding]; other site 522373006913 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 522373006914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373006915 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 522373006916 DNA binding residues [nucleotide binding] 522373006917 HMMPfam hit to PF04542, Sigma-70 region, score 6.3e-10 522373006918 HMMPfam hit to PF08281, Sigma-70, region, score 2.8e-10 522373006919 HMMPfam hit to PF04545, Sigma-70, region, score 1.5e-05 522373006920 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 522373006921 FecR protein; Region: FecR; pfam04773 522373006922 1 probable transmembrane helix predicted for Smlt1751 by TMHMM2.0 at aa 106-128 522373006923 HMMPfam hit to PF04773, FecR protein, score 5.8e-31 522373006924 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 522373006925 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373006926 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373006927 1 probable transmembrane helix predicted for Smlt1753 by TMHMM2.0 at aa 5-27 522373006928 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.7e-10 522373006929 HMMPfam hit to PF00593, TonB dependent receptor, score 5.1e-25 522373006930 PhoD-like phosphatase; Region: PhoD; pfam09423 522373006931 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 522373006932 putative active site [active] 522373006933 putative metal binding site [ion binding]; other site 522373006934 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 522373006935 HMMPfam hit to PF00245, Alkaline phosphatase, score 6.2e-86 522373006936 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 522373006937 Phosphoesterase family; Region: Phosphoesterase; pfam04185 522373006938 Domain of unknown function (DUF756); Region: DUF756; pfam05506 522373006939 Domain of unknown function (DUF756); Region: DUF756; pfam05506 522373006940 HMMPfam hit to PF05506, Domain of unknown function (DUF756), score 5.8e-07 522373006941 HMMPfam hit to PF05506, Domain of unknown function (DUF756), score 5e-26 522373006942 HMMPfam hit to PF04185, Phosphoesterase family, score 5.7e-138 522373006943 1 probable transmembrane helix predicted for Smlt1755 by TMHMM2.0 at aa 13-35 522373006944 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373006945 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373006946 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373006947 HMMPfam hit to PF00593, TonB dependent receptor, score 5.1e-22 522373006948 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2e-14 522373006949 Cytochrome c [Energy production and conversion]; Region: COG3258 522373006950 Cytochrome c; Region: Cytochrom_C; pfam00034 522373006951 1 probable transmembrane helix predicted for Smlt1757 by TMHMM2.0 at aa 7-29 522373006952 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 522373006953 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 522373006954 Cytochrome c; Region: Cytochrom_C; pfam00034 522373006955 HMMPfam hit to PF00034, Cytochrome c, score 0.0048 522373006956 1 probable transmembrane helix predicted for Smlt1758 by TMHMM2.0 at aa 7-29 522373006957 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 522373006958 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373006959 1 probable transmembrane helix predicted for Smlt1759 by TMHMM2.0 at aa 27-49 522373006960 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 7.4e-06 522373006961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373006962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373006963 12 probable transmembrane helices predicted for Smlt1760 by TMHMM2.0 at aa 34-53, 63-85, 94-111, 115-132, 153-175, 180-202, 214-236, 256-275, 288-305, 310-332, 345-367 and 372-394 522373006964 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6.1e-26 522373006965 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 522373006966 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373006967 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 522373006968 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373006969 N-terminal plug; other site 522373006970 ligand-binding site [chemical binding]; other site 522373006971 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1e-17 522373006972 HMMPfam hit to PF00593, TonB dependent receptor, score 2.7e-29 522373006973 Pirin-related protein [General function prediction only]; Region: COG1741 522373006974 Pirin; Region: Pirin; pfam02678 522373006975 HMMPfam hit to PF02678, Pirin, score 2.6e-55 522373006976 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 522373006977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373006978 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373006979 dimerization interface [polypeptide binding]; other site 522373006980 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 9.3e-19 522373006981 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.5e-19 522373006982 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 522373006983 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 522373006984 dimer interface [polypeptide binding]; other site 522373006985 substrate binding site [chemical binding]; other site 522373006986 ATP binding site [chemical binding]; other site 522373006987 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase, score 5.7e-131 522373006988 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 522373006989 6 probable transmembrane helices predicted for Smlt1768 by TMHMM2.0 at aa 7-29, 57-79, 86-108, 113-135, 168-190 and 196-214 522373006990 HMMPfam hit to PF06912, Protein of unknown function (DUF1275), score 5.8e-53 522373006991 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 522373006992 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 522373006993 putative active site [active] 522373006994 PhoH-like protein; Region: PhoH; pfam02562 522373006995 HMMPfam hit to PF02562, PhoH-like protein, score 8.4e-34 522373006996 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 522373006997 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 522373006998 catalytic triad [active] 522373006999 HMMPfam hit to PF08534, Redoxin, score 6.2e-07 522373007000 HMMPfam hit to PF00578, AhpC/TSA family, score 4.1e-11 522373007001 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 522373007002 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 522373007003 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 522373007004 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 522373007005 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 522373007006 dimer interface [polypeptide binding]; other site 522373007007 active site 522373007008 catalytic residue [active] 522373007009 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 1.9e-90 522373007010 1 probable transmembrane helix predicted for Smlt1774 by TMHMM2.0 at aa 7-26 522373007011 Ferredoxin [Energy production and conversion]; Region: COG1146 522373007012 4Fe-4S binding domain; Region: Fer4; cl02805 522373007013 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 522373007014 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 522373007015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373007016 putative substrate translocation pore; other site 522373007017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373007018 12 probable transmembrane helices predicted for Smlt1775 by TMHMM2.0 at aa 232-254, 272-294, 301-323, 327-349, 366-388, 408-430, 484-506, 521-543, 550-572, 592-614, 626-648 and 653-675 522373007019 HMMPfam hit to PF00083, Sugar (and other) transporter score 1.6e-119 522373007020 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.6e-34 522373007021 poly(A) polymerase; Region: pcnB; TIGR01942 522373007022 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 522373007023 active site 522373007024 NTP binding site [chemical binding]; other site 522373007025 metal binding triad [ion binding]; metal-binding site 522373007026 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 522373007027 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 522373007028 HMMPfam hit to PF01743, Poly A polymerase family, score 7.6e-62 522373007029 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 522373007030 catalytic center binding site [active] 522373007031 ATP binding site [chemical binding]; other site 522373007032 HMMPfam hit to PF01288, 7,8-dihydro-6-hydroxymethylpterin-pyrophosph, score 4.9e-57 522373007033 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 522373007034 oligomerization interface [polypeptide binding]; other site 522373007035 active site 522373007036 metal binding site [ion binding]; metal-binding site 522373007037 HMMPfam hit to PF02548, Ketopantoate hydroxymethyltransferase, score 2.1e-123 522373007038 Pantoate-beta-alanine ligase; Region: PanC; cd00560 522373007039 pantoate--beta-alanine ligase; Region: panC; TIGR00018 522373007040 active site 522373007041 ATP-binding site [chemical binding]; other site 522373007042 pantoate-binding site; other site 522373007043 HXXH motif; other site 522373007044 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 3.3e-112 522373007045 3 probable transmembrane helices predicted for Smlt1781 by TMHMM2.0 at aa 21-43, 63-85 and 133-155 522373007046 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 522373007047 tetramerization interface [polypeptide binding]; other site 522373007048 active site 522373007049 HMMPfam hit to PF02261, Aspartate decarboxylase, score 3.9e-68 522373007050 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 522373007051 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 522373007052 active site 522373007053 dimer interface [polypeptide binding]; other site 522373007054 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 522373007055 dimer interface [polypeptide binding]; other site 522373007056 active site 522373007057 HMMPfam hit to PF00342, Phosphoglucose isomerase, score 1.8e-176 522373007058 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 522373007059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373007060 active site 522373007061 phosphorylation site [posttranslational modification] 522373007062 intermolecular recognition site; other site 522373007063 dimerization interface [polypeptide binding]; other site 522373007064 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 522373007065 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis family, score 3.4e-11 522373007066 HMMPfam hit to PF00072, Response regulator receiver domain, score 7.4e-21 522373007067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373007068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 522373007069 dimer interface [polypeptide binding]; other site 522373007070 phosphorylation site [posttranslational modification] 522373007071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373007072 ATP binding site [chemical binding]; other site 522373007073 Mg2+ binding site [ion binding]; other site 522373007074 G-X-G motif; other site 522373007075 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.6e-12 522373007076 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.0041 522373007077 6 probable transmembrane helices predicted for Smlt1785 by TMHMM2.0 at aa 13-35, 40-57, 70-92, 96-113, 115-137 and 152-174 522373007078 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 522373007079 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 522373007080 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 522373007081 HMMPfam hit to PF04551, GcpE protein, score 6.6e-166 522373007082 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 522373007083 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 522373007084 active site 522373007085 6 probable transmembrane helices predicted for Smlt1787 by TMHMM2.0 at aa 27-49, 86-105, 112-129, 149-171, 178-200 and 206-225 522373007086 HMMPfam hit to PF01569, PAP2 superfamily, score 2.2e-26 522373007087 response regulator; Provisional; Region: PRK09483 522373007088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373007089 active site 522373007090 phosphorylation site [posttranslational modification] 522373007091 intermolecular recognition site; other site 522373007092 dimerization interface [polypeptide binding]; other site 522373007093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373007094 DNA binding residues [nucleotide binding] 522373007095 dimerization interface [polypeptide binding]; other site 522373007096 HMMPfam hit to PF00072, Response regulator receiver domain, score 7e-31 522373007097 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 2.8e-21 522373007098 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 522373007099 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 522373007100 active site 522373007101 intersubunit interface [polypeptide binding]; other site 522373007102 catalytic residue [active] 522373007103 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 1.4e-61 522373007104 phosphogluconate dehydratase; Validated; Region: PRK09054 522373007105 6-phosphogluconate dehydratase; Region: edd; TIGR01196 522373007106 HMMPfam hit to PF00920, Dehydratase family, score 2e-257 522373007107 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 522373007108 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 522373007109 putative active site [active] 522373007110 glucokinase, proteobacterial type; Region: glk; TIGR00749 522373007111 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 522373007112 nucleotide binding site [chemical binding]; other site 522373007113 HMMPfam hit to PF02685, Glucokinase, score 4.2e-162 522373007114 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 522373007115 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 522373007116 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 522373007117 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, C-termina, score 3.1e-113 522373007118 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, NAD bindi, score 1.6e-56 522373007119 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 522373007120 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 522373007121 Walker A/P-loop; other site 522373007122 ATP binding site [chemical binding]; other site 522373007123 Q-loop/lid; other site 522373007124 ABC transporter signature motif; other site 522373007125 Walker B; other site 522373007126 D-loop; other site 522373007127 H-loop/switch region; other site 522373007128 TOBE domain; Region: TOBE_2; pfam08402 522373007129 HMMPfam hit to PF00005, ABC transporter score 4.4e-58 522373007130 HMMPfam hit to PF08402, TOBE domain, score 5e-11 522373007131 HMMPfam hit to PF03459, TOBE domain, score 4.9e-08 522373007132 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 522373007133 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 522373007134 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 522373007135 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 9.2e-06 522373007136 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 522373007137 Iron-sulfur protein interface; other site 522373007138 proximal quinone binding site [chemical binding]; other site 522373007139 SdhD (CybS) interface [polypeptide binding]; other site 522373007140 proximal heme binding site [chemical binding]; other site 522373007141 HMMPfam hit to PF01127, Succinate dehydrogenase cytochrome b subunit, score 3.1e-48 522373007142 3 probable transmembrane helices predicted for Smlt1796 by TMHMM2.0 at aa 55-77, 92-114 and 135-157 522373007143 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 522373007144 putative SdhC subunit interface [polypeptide binding]; other site 522373007145 putative proximal heme binding site [chemical binding]; other site 522373007146 putative Iron-sulfur protein interface [polypeptide binding]; other site 522373007147 putative proximal quinone binding site; other site 522373007148 HMMPfam hit to PF01127, Succinate dehydrogenase cytochrome b subunit, score 1.3e-27 522373007149 3 probable transmembrane helices predicted for Smlt1797 by TMHMM2.0 at aa 39-61, 74-93 and 108-130 522373007150 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 522373007151 L-aspartate oxidase; Provisional; Region: PRK06175 522373007152 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 522373007153 HMMPfam hit to PF00890, FAD binding domain, score 4.1e-172 522373007154 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 2.1e-77 522373007155 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 522373007156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 522373007157 catalytic loop [active] 522373007158 iron binding site [ion binding]; other site 522373007159 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 0.0076 522373007160 Uncharacterized conserved protein [Function unknown]; Region: COG2938 522373007161 HMMPfam hit to PF03937, TPR repeat region, score 7.4e-25 522373007162 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 522373007163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373007164 FtsX-like permease family; Region: FtsX; pfam02687 522373007165 4 probable transmembrane helices predicted for Smlt1802 by TMHMM2.0 at aa 21-43, 269-288, 322-344 and 379-401 522373007166 HMMPfam hit to PF02687, Predicted permease, score 7.1e-45 522373007167 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 522373007168 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 522373007169 Walker A/P-loop; other site 522373007170 ATP binding site [chemical binding]; other site 522373007171 Q-loop/lid; other site 522373007172 ABC transporter signature motif; other site 522373007173 Walker B; other site 522373007174 D-loop; other site 522373007175 H-loop/switch region; other site 522373007176 HMMPfam hit to PF00005, ABC transporter score 6.7e-57 522373007177 oxidative damage protection protein; Provisional; Region: PRK05408 522373007178 HMMPfam hit to PF04362, Bacterial Fe(2+) trafficking, score 5.7e-60 522373007179 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 522373007180 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 522373007181 minor groove reading motif; other site 522373007182 helix-hairpin-helix signature motif; other site 522373007183 substrate binding pocket [chemical binding]; other site 522373007184 active site 522373007185 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 522373007186 DNA binding and oxoG recognition site [nucleotide binding] 522373007187 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 1.5e-20 522373007188 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.00054 522373007189 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 522373007190 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 522373007191 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 522373007192 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 1.7e-111 522373007193 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 8.1e-08 522373007194 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 522373007195 heat shock protein 90; Provisional; Region: PRK05218 522373007196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373007197 ATP binding site [chemical binding]; other site 522373007198 Mg2+ binding site [ion binding]; other site 522373007199 G-X-G motif; other site 522373007200 HMMPfam hit to PF00183, Hsp90 protein, score 8.8e-100 522373007201 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 9.2e-15 522373007202 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 522373007203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373007204 S-adenosylmethionine binding site [chemical binding]; other site 522373007205 HMMPfam hit to PF03602, Conserved hypothetical protein, score 7.6e-66 522373007206 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 522373007207 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 522373007208 active site 522373007209 (T/H)XGH motif; other site 522373007210 HMMPfam hit to PF01467, Cytidylyltransferase, score 7e-30 522373007211 ferredoxin; Validated; Region: PRK07118 522373007212 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 7e-05 522373007213 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 522373007214 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 522373007215 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 2e-232 522373007216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 522373007217 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 2.3e-11 522373007218 psiF repeat; Region: PsiF_repeat; pfam07769 522373007219 hypothetical protein; Provisional; Region: PRK11505 522373007220 HMMPfam hit to PF07769, psiF repeat, score 3.7e-15 522373007221 HMMPfam hit to PF07769, psiF repeat, score 7e-06 522373007222 1 probable transmembrane helix predicted for Smlt1816 by TMHMM2.0 at aa 15-37 522373007223 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373007224 dimerization interface [polypeptide binding]; other site 522373007225 putative DNA binding site [nucleotide binding]; other site 522373007226 putative Zn2+ binding site [ion binding]; other site 522373007227 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 5.1e-08 522373007228 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 522373007229 putative hydrophobic ligand binding site [chemical binding]; other site 522373007230 HMMPfam hit to PF08327, Activator of Hsp90 ATPase homolog 1-like pro, score 1.6e-31 522373007231 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 522373007232 active site 522373007233 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 3.7e-11 522373007234 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 522373007235 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373007236 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373007237 ligand-binding site [chemical binding]; other site 522373007238 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.4e-17 522373007239 HMMPfam hit to PF00593, TonB dependent receptor, score 1.2e-28 522373007240 Phytase; Region: Phytase; cl17685 522373007241 HMMPfam hit to PF01436, NHL repeat, score 2.1e-07 522373007242 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 522373007243 active site 522373007244 metal binding site [ion binding]; metal-binding site 522373007245 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 522373007246 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 522373007247 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.5e-11 522373007248 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 522373007249 dimer interface [polypeptide binding]; other site 522373007250 substrate binding site [chemical binding]; other site 522373007251 metal binding sites [ion binding]; metal-binding site 522373007252 1 probable transmembrane helix predicted for Smlt1823 by TMHMM2.0 at aa 27-49 522373007253 HMMPfam hit to PF00719, Inorganic pyrophosphatase, score 3.2e-53 522373007254 DNA photolyase; Region: DNA_photolyase; pfam00875 522373007255 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 522373007256 HMMPfam hit to PF00875, DNA photolyase, score 5.6e-51 522373007257 HMMPfam hit to PF03441, FAD binding domain of DNA photolyase, score 1.4e-87 522373007258 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 522373007259 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 522373007260 ligand binding site [chemical binding]; other site 522373007261 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 5.7e-11 522373007262 HMMPfam hit to PF00691, OmpA family, score 8.3e-41 522373007263 LysR family transcriptional regulator; Provisional; Region: PRK14997 522373007264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373007265 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373007266 putative effector binding pocket; other site 522373007267 dimerization interface [polypeptide binding]; other site 522373007268 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.9e-45 522373007269 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.4e-15 522373007270 putative DeoR family transcriptional regulator;Similar to N-terminus of Rhodospirillum rubrum (strain atcc 11170/ncib 8255). transcriptional regulator, deor family. UniProt:Q2RV65 (EMBL:CP000230 (254 aa) fasta scores: E()=1.1, 35.616% id in 73 aa; similarity:fasta; with=UniProt:Q2RV65 (EMBL:CP000230;); Rhodospirillum rubrum (strain ATCC 11170/NCIB 8255).; Transcriptional Regulator, DeoR family.; length=254; id 35.616%; ungapped id 39.394%; E()=1.1; 73 aa overlap; query 6-72; subject 13-84 522373007271 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 522373007272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373007273 NAD(P) binding site [chemical binding]; other site 522373007274 active site 522373007275 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.7e-05 522373007276 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373007277 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373007278 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373007279 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.1e-53 522373007280 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 522373007281 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373007282 12 probable transmembrane helices predicted for Smlt1831 by TMHMM2.0 at aa 12-34, 342-361, 368-390, 396-418, 439-461, 471-493, 541-563, 879-898, 905-927, 932-954, 975-997 and 1012-1034 522373007283 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 522373007284 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 522373007285 NADP binding site [chemical binding]; other site 522373007286 substrate binding site [chemical binding]; other site 522373007287 active site 522373007288 HMMPfam hit to PF00106, short chain dehydrogenase, score 4.5e-26 522373007289 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 522373007290 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.6e-28 522373007291 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.5e-37 522373007292 2 probable transmembrane helices predicted for Smlt1835 by TMHMM2.0 at aa 21-43 and 53-70 522373007293 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 522373007294 putative catalytic site [active] 522373007295 putative metal binding site [ion binding]; other site 522373007296 putative phosphate binding site [ion binding]; other site 522373007297 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 2.9e-20 522373007298 1 probable transmembrane helix predicted for Smlt1836 by TMHMM2.0 at aa 21-40 522373007299 1 probable transmembrane helix predicted for Smlt1837 by TMHMM2.0 at aa 20-42 522373007300 1 probable transmembrane helix predicted for Smlt1838 by TMHMM2.0 at aa 21-40 522373007301 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 522373007302 Autoinducer binding domain; Region: Autoind_bind; pfam03472 522373007303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373007304 DNA binding residues [nucleotide binding] 522373007305 dimerization interface [polypeptide binding]; other site 522373007306 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 4.3e-18 522373007307 HMMPfam hit to PF04967, HTH DNA binding domain, score 0.003 522373007308 HMMPfam hit to PF08281, Sigma-70, region, score 1.5e-06 522373007309 HMMPfam hit to PF03472, Autoinducer binding domain, score 2.1e-10 522373007310 chaperone protein HchA; Provisional; Region: PRK04155 522373007311 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 522373007312 conserved cys residue [active] 522373007313 HMMPfam hit to PF01965, DJ-1/PfpI family, score 2.3e-05 522373007314 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 522373007315 Putative serine esterase (DUF676); Region: DUF676; pfam05057 522373007316 HMMPfam hit to PF05057, Putative serine esterase (DUF676), score 0.004 522373007317 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 522373007318 3 probable transmembrane helices predicted for Smlt1842 by TMHMM2.0 at aa 12-29, 39-56 and 105-127 522373007319 Methyltransferase domain; Region: Methyltransf_26; pfam13659 522373007320 DNA methylase; Region: N6_N4_Mtase; cl17433 522373007321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373007322 Transposase; Region: HTH_Tnp_1; pfam01527 522373007323 HMMPfam hit to PF01527, Transposase, score 1.1e-21 522373007324 putative transposase OrfB; Reviewed; Region: PHA02517 522373007325 HTH-like domain; Region: HTH_21; pfam13276 522373007326 Integrase core domain; Region: rve; pfam00665 522373007327 Integrase core domain; Region: rve_2; pfam13333 522373007328 HMMPfam hit to PF00665, Integrase core domain, score 9e-51 522373007329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373007330 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 522373007331 Walker A motif; other site 522373007332 ATP binding site [chemical binding]; other site 522373007333 Walker B motif; other site 522373007334 arginine finger; other site 522373007335 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.7e-05 522373007336 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 4.6e-26 522373007337 HMMPfam hit to PF07726, ATPase family associated with various cellul, score 1.6e-05 522373007338 1 probable transmembrane helix predicted for Smlt1849 by TMHMM2.0 at aa 32-54 522373007339 1 probable transmembrane helix predicted for Smlt1850 by TMHMM2.0 at aa 4-26 522373007340 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 522373007341 catalytic residues [active] 522373007342 HMMPfam hit to PF00959, Phage lysozyme, score 6.7e-14 522373007343 1 probable transmembrane helix predicted for Smlt1852 by TMHMM2.0 at aa 72-91 522373007344 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 522373007345 Putative phage tail protein; Region: Phage-tail_3; pfam13550 522373007346 1 probable transmembrane helix predicted for Smlt1856 by TMHMM2.0 at aa 2-19 522373007347 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 522373007348 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 522373007349 1 probable transmembrane helix predicted for Smlt1860 by TMHMM2.0 at aa 748-770 522373007350 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 522373007351 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 522373007352 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 522373007353 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 522373007354 tandem repeat interface [polypeptide binding]; other site 522373007355 oligomer interface [polypeptide binding]; other site 522373007356 active site residues [active] 522373007357 HMMPfam hit to PF01343, Peptidase family S49, score 3.8e-36 522373007358 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 522373007359 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 522373007360 HMMPfam hit to PF05136, Phage portal protein, lambda family, score 4.1e-36 522373007361 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 522373007362 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 522373007363 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 522373007364 HMMPfam hit to PF05876, Phage terminase large subunit (GpA), score 0 522373007365 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 522373007366 Winged helix-turn helix; Region: HTH_29; pfam13551 522373007367 Homeodomain-like domain; Region: HTH_32; pfam13565 522373007368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 522373007369 Integrase core domain; Region: rve; pfam00665 522373007370 Integrase core domain; Region: rve_3; pfam13683 522373007371 HMMPfam hit to PF00665, Integrase core domain, score 2.2e-26 522373007372 ParB-like nuclease domain; Region: ParBc; pfam02195 522373007373 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 522373007374 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 522373007375 DNA methylase; Region: N6_N4_Mtase; pfam01555 522373007376 HMMPfam hit to PF01555, DNA methylase, score 1e-24 522373007377 HMMPfam hit to PF02195, ParB-like nuclease domain, score 6.4e-17 522373007378 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 522373007379 ParB-like nuclease domain; Region: ParBc; pfam02195 522373007380 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 522373007381 DNA methylase; Region: N6_N4_Mtase; pfam01555 522373007382 HMMPfam hit to PF01555, DNA methylase, score 1.3e-20 522373007383 HMMPfam hit to PF02195, ParB-like nuclease domain, score 2.3e-17 522373007384 hypothetical protein; Validated; Region: PRK07078 522373007385 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 522373007386 active site 522373007387 metal binding site [ion binding]; metal-binding site 522373007388 interdomain interaction site; other site 522373007389 D5 N terminal like; Region: D5_N; smart00885 522373007390 HMMPfam hit to PF03288, Poxvirus D5 protein-like, score 7.2e-36 522373007391 AAA domain; Region: AAA_24; pfam13479 522373007392 Prophage antirepressor [Transcription]; Region: COG3617 522373007393 BRO family, N-terminal domain; Region: Bro-N; smart01040 522373007394 HMMPfam hit to PF02498, BRO family, N-terminal domain, score 6.3e-33 522373007395 Helix-turn-helix domain; Region: HTH_17; cl17695 522373007396 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 522373007397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373007398 non-specific DNA binding site [nucleotide binding]; other site 522373007399 salt bridge; other site 522373007400 sequence-specific DNA binding site [nucleotide binding]; other site 522373007401 HMMPfam hit to PF01381, Helix-turn-helix, score 9.1e-09 522373007402 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 522373007403 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 522373007404 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 522373007405 catalytic residues [active] 522373007406 catalytic nucleophile [active] 522373007407 Presynaptic Site I dimer interface [polypeptide binding]; other site 522373007408 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 522373007409 Synaptic Flat tetramer interface [polypeptide binding]; other site 522373007410 Synaptic Site I dimer interface [polypeptide binding]; other site 522373007411 DNA binding site [nucleotide binding] 522373007412 Recombinase; Region: Recombinase; pfam07508 522373007413 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 522373007414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373007415 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 522373007416 non-specific DNA binding site [nucleotide binding]; other site 522373007417 salt bridge; other site 522373007418 sequence-specific DNA binding site [nucleotide binding]; other site 522373007419 Domain of unknown function (DUF955); Region: DUF955; cl01076 522373007420 HMMPfam hit to PF01381, Helix-turn-helix, score 4.4e-13 522373007421 HMMPfam hit to PF06114, Domain of unknown function (DUF955), score 8e-18 522373007422 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 522373007423 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 522373007424 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 522373007425 active site 522373007426 DNA binding site [nucleotide binding] 522373007427 Int/Topo IB signature motif; other site 522373007428 HMMPfam hit to PF00589, Phage integrase family, score 2.8e-11 522373007429 HNH endonuclease; Region: HNH_3; pfam13392 522373007430 recombination associated protein; Reviewed; Region: rdgC; PRK00321 522373007431 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 522373007432 DNA binding site [nucleotide binding] 522373007433 1 probable transmembrane helix predicted for Smlt1923 by TMHMM2.0 at aa 7-29 522373007434 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 522373007435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373007436 non-specific DNA binding site [nucleotide binding]; other site 522373007437 salt bridge; other site 522373007438 sequence-specific DNA binding site [nucleotide binding]; other site 522373007439 Helix-turn-helix domain; Region: HTH_36; pfam13730 522373007440 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 522373007441 1 probable transmembrane helix predicted for Smlt1939 by TMHMM2.0 at aa 15-33 522373007442 1 probable transmembrane helix predicted for Smlt1940 by TMHMM2.0 at aa 12-34 522373007443 3 probable transmembrane helices predicted for Smlt1941 by TMHMM2.0 at aa 7-29, 39-61 and 68-90 522373007444 1 probable transmembrane helix predicted for Smlt1943 by TMHMM2.0 at aa 61-83 522373007445 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 522373007446 catalytic residue [active] 522373007447 2 probable transmembrane helices predicted for Smlt1944 by TMHMM2.0 at aa 12-31 and 41-63 522373007448 HMMPfam hit to PF00959, Phage lysozyme, score 7.8e-08 522373007449 1 probable transmembrane helix predicted for Smlt1945 by TMHMM2.0 at aa 20-42 522373007450 Terminase small subunit; Region: Terminase_2; cl01513 522373007451 HMMPfam hit to PF03592, Terminase small subunit, score 1e-13 522373007452 large terminase protein; Provisional; Region: 17; PHA02533 522373007453 Terminase-like family; Region: Terminase_6; pfam03237 522373007454 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 522373007455 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 522373007456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 522373007457 active site 522373007458 conserved hypothetical protein, partial;similarity:fasta; with=UniProt:Q2H5K0; Chaetomium globosum CBS 148.51.; Predicted protein.; length=188; id 26.415%; ungapped id 27.723%; E()=4.6; 106 aa overlap; query 1-101; subject 1-106 522373007459 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 522373007460 3 probable transmembrane helices predicted for Smlt1982 by TMHMM2.0 at aa 43-65, 72-89 and 99-118 522373007461 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 522373007462 SmpB-tmRNA interface; other site 522373007463 HMMPfam hit to PF01668, SmpB protein, score 5.2e-39 522373007464 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 522373007465 putative coenzyme Q binding site [chemical binding]; other site 522373007466 hypothetical protein; Validated; Region: PRK01777 522373007467 HMMPfam hit to PF03658, Uncharacterised protein family (UPF0125), score 2.9e-10 522373007468 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 522373007469 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 522373007470 HMMPfam hit to PF04355, SmpA / OmlA family, score 4.8e-26 522373007471 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 522373007472 metal binding site 2 [ion binding]; metal-binding site 522373007473 putative DNA binding helix; other site 522373007474 metal binding site 1 [ion binding]; metal-binding site 522373007475 dimer interface [polypeptide binding]; other site 522373007476 structural Zn2+ binding site [ion binding]; other site 522373007477 HMMPfam hit to PF01475, Ferric uptake regulator family, score 1.8e-60 522373007478 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 522373007479 active site 522373007480 catalytic triad [active] 522373007481 oxyanion hole [active] 522373007482 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 1.2e-28 522373007483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373007484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373007485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373007486 dimerization interface [polypeptide binding]; other site 522373007487 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.6e-17 522373007488 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-38 522373007489 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 522373007490 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 522373007491 Walker A/P-loop; other site 522373007492 ATP binding site [chemical binding]; other site 522373007493 Q-loop/lid; other site 522373007494 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 522373007495 ABC transporter signature motif; other site 522373007496 Walker B; other site 522373007497 D-loop; other site 522373007498 H-loop/switch region; other site 522373007499 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 9.3e-13 522373007500 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 522373007501 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 522373007502 HMMPfam hit to PF01628, HrcA protein C terminal domain, score 4.5e-44 522373007503 GrpE; Region: GrpE; pfam01025 522373007504 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 522373007505 dimer interface [polypeptide binding]; other site 522373007506 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 522373007507 HMMPfam hit to PF01025, GrpE, score 4.8e-55 522373007508 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 522373007509 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 522373007510 nucleotide binding site [chemical binding]; other site 522373007511 HMMPfam hit to PF00012, Hsp70 protein, score 0 522373007512 chaperone protein DnaJ; Provisional; Region: PRK10767 522373007513 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 522373007514 HSP70 interaction site [polypeptide binding]; other site 522373007515 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 522373007516 substrate binding site [polypeptide binding]; other site 522373007517 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 522373007518 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 522373007519 dimer interface [polypeptide binding]; other site 522373007520 HMMPfam hit to PF00226, DnaJ domain, score 9.6e-36 522373007521 HMMPfam hit to PF00684, DnaJ central domain (4 repeats), score 1.1e-36 522373007522 HMMPfam hit to PF01556, DnaJ C terminal region, score 4.2e-73 522373007523 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 522373007524 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 522373007525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373007526 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 1.1e-06 522373007527 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 0.00038 522373007528 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 4.1e-06 522373007529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373007530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373007531 putative substrate translocation pore; other site 522373007532 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.8e-42 522373007533 10 probable transmembrane helices predicted for Smlt1995 by TMHMM2.0 at aa 35-57, 101-123, 144-166, 171-193, 220-242, 257-279, 286-303, 308-330, 343-365 and 369-391 522373007534 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 522373007535 dimer interface [polypeptide binding]; other site 522373007536 pyridoxamine kinase; Validated; Region: PRK05756 522373007537 pyridoxal binding site [chemical binding]; other site 522373007538 ATP binding site [chemical binding]; other site 522373007539 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase, score 6.9e-08 522373007540 prephenate dehydrogenase; Provisional; Region: PRK08818 522373007541 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 522373007542 prephenate dehydrogenase; Validated; Region: PRK08507 522373007543 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 522373007544 HMMPfam hit to PF02153, Prephenate dehydrogenase, score 7e-10 522373007545 HMMPfam hit to PF01842, ACT domain, score 0.0001 522373007546 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 522373007547 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 522373007548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373007549 Walker A/P-loop; other site 522373007550 ATP binding site [chemical binding]; other site 522373007551 Q-loop/lid; other site 522373007552 ABC transporter signature motif; other site 522373007553 Walker B; other site 522373007554 D-loop; other site 522373007555 H-loop/switch region; other site 522373007556 HMMPfam hit to PF00005, ABC transporter score 1.1e-70 522373007557 5 probable transmembrane helices predicted for Smlt2001 by TMHMM2.0 at aa 33-55, 72-94, 172-191, 254-276 and 291-313 522373007558 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 4.8e-44 522373007559 Uncharacterized conserved protein [Function unknown]; Region: COG1739 522373007560 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 522373007561 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 522373007562 HMMPfam hit to PF01205, Uncharacterized protein family UPF0029, score 6.5e-57 522373007563 1 probable transmembrane helix predicted for Smlt2003 by TMHMM2.0 at aa 65-84 522373007564 RNA polymerase sigma factor; Provisional; Region: PRK12513 522373007565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373007566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373007567 DNA binding residues [nucleotide binding] 522373007568 HMMPfam hit to PF04545, Sigma-70, region, score 1.6e-20 522373007569 HMMPfam hit to PF08281, Sigma-70, region, score 2.6e-12 522373007570 HMMPfam hit to PF04542, Sigma-70 region, score 1.5e-16 522373007571 GAF domain; Region: GAF; cl17456 522373007572 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 522373007573 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 522373007574 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373007575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373007576 metal binding site [ion binding]; metal-binding site 522373007577 active site 522373007578 I-site; other site 522373007579 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373007580 HMMPfam hit to PF01590, GAF domain, score 2.7e-05 522373007581 HMMPfam hit to PF01590, GAF domain, score 2.5e-15 522373007582 HMMPfam hit to PF00990, GGDEF domain, score 1.7e-58 522373007583 HMMPfam hit to PF00563, EAL domain, score 1.7e-99 522373007584 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 522373007585 HMMPfam hit to PF03641, Possible lysine decarboxylase, score 2.1e-54 522373007586 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 522373007587 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 522373007588 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373007589 catalytic residue [active] 522373007590 HMMPfam hit to PF00202, Aminotransferase class-III, score 4.6e-11 522373007591 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 522373007592 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 522373007593 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 3.1e-88 522373007594 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 522373007595 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 522373007596 HMMPfam hit to PF01702, Queuine tRNA-ribosyltransferase, score 4.9e-125 522373007597 2 probable transmembrane helices predicted for Smlt2010 by TMHMM2.0 at aa 13-31 and 36-58 522373007598 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 522373007599 HMMPfam hit to PF02699, Preprotein translocase subunit, score 4.7e-34 522373007600 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 522373007601 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 522373007602 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 522373007603 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 522373007604 6 probable transmembrane helices predicted for Smlt2011 by TMHMM2.0 at aa 17-36, 464-481, 486-508, 512-534, 561-583 and 588-610 522373007605 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 1.2e-06 522373007606 HMMPfam hit to PF02355, Protein export membrane protein, score 3.3e-09 522373007607 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 522373007608 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 522373007609 Protein export membrane protein; Region: SecD_SecF; pfam02355 522373007610 6 probable transmembrane helices predicted for Smlt2012 by TMHMM2.0 at aa 20-41, 148-167, 174-196, 201-223, 248-270 and 285-307 522373007611 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 1.9e-05 522373007612 HMMPfam hit to PF02355, Protein export membrane protein, score 3.3e-41 522373007613 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 522373007614 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 522373007615 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 522373007616 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 522373007617 HMMPfam hit to PF07055, Short-chain alcohol dehydrogenase, score 3.6e-275 522373007618 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373007619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373007620 active site 522373007621 phosphorylation site [posttranslational modification] 522373007622 dimerization interface [polypeptide binding]; other site 522373007623 PAS domain S-box; Region: sensory_box; TIGR00229 522373007624 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373007625 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373007626 metal binding site [ion binding]; metal-binding site 522373007627 active site 522373007628 I-site; other site 522373007629 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373007630 HMMPfam hit to PF00563, EAL domain, score 4.7e-40 522373007631 HMMPfam hit to PF00990, GGDEF domain, score 1.1e-07 522373007632 HI0933-like protein; Region: HI0933_like; pfam03486 522373007633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373007634 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 522373007635 HMMPfam hit to PF03486, HI0933-like protein, score 2.9e-231 522373007636 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.6e-07 522373007637 HMMPfam hit to PF00890, FAD binding domain, score 0.0021 522373007638 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 0.00031 522373007639 YaeQ protein; Region: YaeQ; pfam07152 522373007640 HMMPfam hit to PF07152, YaeQ protein, score 7.3e-107 522373007641 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 522373007642 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 522373007643 active site 522373007644 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.7e-30 522373007645 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 522373007646 HMMPfam hit to PF02639, Uncharacterized BCR, YaiI/YqxD family COG167, score 4.2e-62 522373007647 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 522373007648 DNA-binding site [nucleotide binding]; DNA binding site 522373007649 RNA-binding motif; other site 522373007650 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 6.2e-38 522373007651 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 522373007652 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 522373007653 putative C-terminal domain interface [polypeptide binding]; other site 522373007654 putative GSH binding site (G-site) [chemical binding]; other site 522373007655 putative dimer interface [polypeptide binding]; other site 522373007656 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 522373007657 putative N-terminal domain interface [polypeptide binding]; other site 522373007658 putative dimer interface [polypeptide binding]; other site 522373007659 putative substrate binding pocket (H-site) [chemical binding]; other site 522373007660 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 1.6e-15 522373007661 hypothetical protein; Validated; Region: PRK00029 522373007662 Uncharacterized conserved protein [Function unknown]; Region: COG0397 522373007663 HMMPfam hit to PF02696, Uncharacterized ACR, YdiU/UPF0061 family, score 1.5e-96 522373007664 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 522373007665 active site 522373007666 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 5.5e-40 522373007667 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 522373007668 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 522373007669 ATP binding site [chemical binding]; other site 522373007670 Mg++ binding site [ion binding]; other site 522373007671 motif III; other site 522373007672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373007673 nucleotide binding region [chemical binding]; other site 522373007674 ATP-binding site [chemical binding]; other site 522373007675 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 522373007676 putative RNA binding site [nucleotide binding]; other site 522373007677 HMMPfam hit to PF03880, DbpA RNA binding domain, score 1.7e-23 522373007678 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 5.8e-31 522373007679 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 3.6e-65 522373007680 Predicted membrane protein [Function unknown]; Region: COG2855 522373007681 10 probable transmembrane helices predicted for Smlt2028 by TMHMM2.0 at aa 32-54, 59-81, 115-137, 149-171, 181-203, 216-238, 253-270, 282-304, 314-336 and 343-365 522373007682 HMMPfam hit to PF03601, Conserved hypothetical protein, score 2.8e-144 522373007683 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 522373007684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373007685 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 522373007686 putative dimerization interface [polypeptide binding]; other site 522373007687 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4e-15 522373007688 HMMPfam hit to PF03466, LysR substrate binding domain, score 7e-41 522373007689 ABC transporter ATPase component; Reviewed; Region: PRK11147 522373007690 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 522373007691 Walker A/P-loop; other site 522373007692 ATP binding site [chemical binding]; other site 522373007693 Q-loop/lid; other site 522373007694 ABC transporter signature motif; other site 522373007695 Walker B; other site 522373007696 D-loop; other site 522373007697 H-loop/switch region; other site 522373007698 ABC transporter; Region: ABC_tran_2; pfam12848 522373007699 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 522373007700 HMMPfam hit to PF00005, ABC transporter score 1.1e-52 522373007701 HMMPfam hit to PF00005, ABC transporter score 6.4e-47 522373007702 Cytochrome c553 [Energy production and conversion]; Region: COG2863 522373007703 HMMPfam hit to PF00034, Cytochrome c, score 0.00099 522373007704 Cytochrome c; Region: Cytochrom_C; cl11414 522373007705 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373007706 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373007707 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373007708 HMMPfam hit to PF00529, HlyD family secretion protein, score 5.4e-08 522373007709 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 522373007710 Protein export membrane protein; Region: SecD_SecF; cl14618 522373007711 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 2.9e-243 522373007712 10 probable transmembrane helices predicted for Smlt2034 by TMHMM2.0 at aa 34-52, 412-427, 434-456, 507-526, 538-560, 978-1000, 1007-1029, 1034-1056, 1082-1104 and 1114-1136 522373007713 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 522373007714 Protein export membrane protein; Region: SecD_SecF; cl14618 522373007715 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 7.2e-158 522373007716 12 probable transmembrane helices predicted for Smlt2035 by TMHMM2.0 at aa 12-34, 331-350, 357-379, 383-404, 424-446, 456-478, 515-537, 839-861, 866-888, 898-920, 941-963 and 978-1000 522373007717 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 522373007718 3 probable transmembrane helices predicted for Smlt2036 by TMHMM2.0 at aa 278-300, 315-337 and 390-409 522373007719 HMMPfam hit to PF01963, TraB family, score 2.9e-69 522373007720 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 522373007721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373007722 Coenzyme A binding pocket [chemical binding]; other site 522373007723 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.7e-21 522373007724 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 522373007725 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 522373007726 putative active site; other site 522373007727 catalytic triad [active] 522373007728 putative dimer interface [polypeptide binding]; other site 522373007729 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 6.1e-63 522373007730 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 522373007731 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 522373007732 HMMPfam hit to PF04371, Porphyromonas-type peptidyl-arginine deimin, score 1.2e-165 522373007733 1 probable transmembrane helix predicted for Smlt2040 by TMHMM2.0 at aa 5-27 522373007734 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 522373007735 HMMPfam hit to PF00444, Ribosomal protein L36, score 5.4e-06 522373007736 cytidylate kinase; Provisional; Region: cmk; PRK00023 522373007737 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 522373007738 CMP-binding site; other site 522373007739 The sites determining sugar specificity; other site 522373007740 HMMPfam hit to PF02224, Cytidylate kinase, score 1.9e-65 522373007741 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 522373007742 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 522373007743 RNA binding site [nucleotide binding]; other site 522373007744 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 522373007745 RNA binding site [nucleotide binding]; other site 522373007746 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 522373007747 RNA binding site [nucleotide binding]; other site 522373007748 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 522373007749 RNA binding site [nucleotide binding]; other site 522373007750 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 522373007751 RNA binding site [nucleotide binding]; other site 522373007752 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 522373007753 RNA binding site [nucleotide binding]; other site 522373007754 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.2e-08 522373007755 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.8e-15 522373007756 HMMPfam hit to PF00575, S1 RNA binding domain, score 6.1e-33 522373007757 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.2e-29 522373007758 HMMPfam hit to PF00575, S1 RNA binding domain, score 6e-25 522373007759 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.1e-18 522373007760 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 522373007761 IHF dimer interface [polypeptide binding]; other site 522373007762 IHF - DNA interface [nucleotide binding]; other site 522373007763 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 6.5e-44 522373007764 2 probable transmembrane helices predicted for Smlt2045 by TMHMM2.0 at aa 7-29 and 44-66 522373007765 tetratricopeptide repeat protein; Provisional; Region: PRK11788 522373007766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373007767 binding surface 522373007768 TPR motif; other site 522373007769 1 probable transmembrane helix predicted for Smlt2046 by TMHMM2.0 at aa 7-24 522373007770 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 522373007771 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 522373007772 Mg++ binding site [ion binding]; other site 522373007773 putative catalytic motif [active] 522373007774 putative substrate binding site [chemical binding]; other site 522373007775 9 probable transmembrane helices predicted for Smlt2047 by TMHMM2.0 at aa 31-50, 55-74, 86-100, 105-127, 140-162, 177-199, 206-228, 252-274 and 281-300 522373007776 HMMPfam hit to PF00953, Glycosyl transferase family, score 2.1e-18 522373007777 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 522373007778 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 522373007779 NAD(P) binding site [chemical binding]; other site 522373007780 homodimer interface [polypeptide binding]; other site 522373007781 substrate binding site [chemical binding]; other site 522373007782 active site 522373007783 4 probable transmembrane helices predicted for Smlt2048 by TMHMM2.0 at aa 12-34, 49-71, 84-103 and 113-132 522373007784 HMMPfam hit to PF02629, CoA binding domain, score 0.055 522373007785 HMMPfam hit to PF00106, short chain dehydrogenase, score 5.2e-07 522373007786 HMMPfam hit to PF04321, RmlD substrate binding domain, score 3.7e-06 522373007787 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 5.6e-166 522373007788 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 2.5e-13 522373007789 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 2.6e-05 522373007790 HMMPfam hit to PF07993, Male sterility protein, score 6e-05 522373007791 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 522373007792 active site 522373007793 tetramer interface; other site 522373007794 HMMPfam hit to PF00483, Nucleotidyl transferase, score 3.4e-15 522373007795 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 522373007796 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 522373007797 dimer interface [polypeptide binding]; other site 522373007798 active site 522373007799 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 1.6e-67 522373007800 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 1.3e-101 522373007801 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 522373007802 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 522373007803 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 522373007804 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 2.5e-10 522373007805 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 5.3e-06 522373007806 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 2.4e-58 522373007807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373007808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373007809 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2.8e-17 522373007810 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 522373007811 active site 522373007812 multimer interface [polypeptide binding]; other site 522373007813 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, score 1.2e-79 522373007814 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 522373007815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373007816 FeS/SAM binding site; other site 522373007817 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.5e-17 522373007818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373007819 binding surface 522373007820 TPR motif; other site 522373007821 Tetratricopeptide repeat; Region: TPR_12; pfam13424 522373007822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373007823 binding surface 522373007824 TPR motif; other site 522373007825 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.00013 522373007826 HMMPfam hit to PF07721, no description, score 0.018 522373007827 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 522373007828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373007829 non-specific DNA binding site [nucleotide binding]; other site 522373007830 salt bridge; other site 522373007831 sequence-specific DNA binding site [nucleotide binding]; other site 522373007832 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 522373007833 1 probable transmembrane helix predicted for Smlt2057 by TMHMM2.0 at aa 114-131 522373007834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 522373007835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 522373007836 binding surface 522373007837 TPR motif; other site 522373007838 1 probable transmembrane helix predicted for Smlt2058 by TMHMM2.0 at aa 32-51 522373007839 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 522373007840 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 522373007841 Trp docking motif [polypeptide binding]; other site 522373007842 HMMPfam hit to PF01011, PQQ enzyme repeat, score 1e-08 522373007843 GTP-binding protein Der; Reviewed; Region: PRK00093 522373007844 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 522373007845 G1 box; other site 522373007846 GTP/Mg2+ binding site [chemical binding]; other site 522373007847 Switch I region; other site 522373007848 G2 box; other site 522373007849 Switch II region; other site 522373007850 G3 box; other site 522373007851 G4 box; other site 522373007852 G5 box; other site 522373007853 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 522373007854 G1 box; other site 522373007855 GTP/Mg2+ binding site [chemical binding]; other site 522373007856 Switch I region; other site 522373007857 G2 box; other site 522373007858 G3 box; other site 522373007859 Switch II region; other site 522373007860 G4 box; other site 522373007861 G5 box; other site 522373007862 HMMPfam hit to PF01926, GTPase of unknown function, score 5.1e-44 522373007863 HMMPfam hit to PF01926, GTPase of unknown function, score 7.4e-44 522373007864 5 probable transmembrane helices predicted for Smlt2061 by TMHMM2.0 at aa 4-26, 39-61, 122-144, 151-173 and 193-215 522373007865 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 522373007866 5 probable transmembrane helices predicted for Smlt2062 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 156-178 and 188-210 522373007867 HMMPfam hit to PF01810, LysE type translocator, score 6.2e-10 522373007868 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 522373007869 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 522373007870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373007871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373007872 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 4.6e-10 522373007873 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 2.5e-05 522373007874 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 0.00073 522373007875 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 522373007876 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 522373007877 active site residue [active] 522373007878 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 522373007879 ATP binding site [chemical binding]; other site 522373007880 substrate interface [chemical binding]; other site 522373007881 HMMPfam hit to PF00581, Rhodanese-like domain, score 4.7e-05 522373007882 HMMPfam hit to PF00899, ThiF family, score 1.8e-69 522373007883 1 probable transmembrane helix predicted for Smlt2064 by TMHMM2.0 at aa 183-205 522373007884 HMMPfam hit to PF05237, MoeZ/MoeB domain, score 8.1e-45 522373007885 putative molybdopterin biosynthesis protein, pseudogene;Similar to C-terminus of Xylella fastidiosa (strain temecula1/atcc 700964). moeb UniProt:Q87B42 (EMBL:AE009442 (294 aa) fasta scores: E()=1.6e-05, 88.000% id in 25 aa; similarity:fasta; with=UniProt:Q87B42 (EMBL:AE009442;); Xylella fastidiosa (strain Temecula1/ATCC 700964).; moeB; Molybdopterin biosynthesis protein.; length=294; id 88.000%; ungapped id 88.000%; E()=1.6e-05; 25 aa overlap; query 29-53; subject 267-291 522373007886 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 522373007887 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 522373007888 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 522373007889 TrkA-N domain; Region: TrkA_N; pfam02254 522373007890 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 8.1e-66 522373007891 11 probable transmembrane helices predicted for Smlt2066 by TMHMM2.0 at aa 9-31, 36-55, 68-90, 95-117, 130-152, 165-187, 208-230, 250-272, 279-298, 313-335 and 342-361 522373007892 HMMPfam hit to PF02254, TrkA-N domain, score 2.3e-22 522373007893 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 522373007894 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 522373007895 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 522373007896 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 522373007897 homodimer interface [polypeptide binding]; other site 522373007898 NADP binding site [chemical binding]; other site 522373007899 substrate binding site [chemical binding]; other site 522373007900 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohyd, score 3e-55 522373007901 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohyd, score 2e-98 522373007902 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 522373007903 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 522373007904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 522373007905 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 522373007906 active site 522373007907 HMMPfam hit to PF00478, IMP dehydrogenase / GMP reductase domain, score 2.4e-238 522373007908 HMMPfam hit to PF00571, CBS domain pair, score 7.6e-25 522373007909 GMP synthase; Reviewed; Region: guaA; PRK00074 522373007910 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 522373007911 AMP/PPi binding site [chemical binding]; other site 522373007912 candidate oxyanion hole; other site 522373007913 catalytic triad [active] 522373007914 potential glutamine specificity residues [chemical binding]; other site 522373007915 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 522373007916 ATP Binding subdomain [chemical binding]; other site 522373007917 Ligand Binding sites [chemical binding]; other site 522373007918 Dimerization subdomain; other site 522373007919 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.8e-54 522373007920 HMMPfam hit to PF00958, GMP synthase C terminal domain, score 3.6e-55 522373007921 1 probable transmembrane helix predicted for Smlt2077 by TMHMM2.0 at aa 58-80 522373007922 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373007923 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373007924 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373007925 putative effector binding pocket; other site 522373007926 dimerization interface [polypeptide binding]; other site 522373007927 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.4e-50 522373007928 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.9e-21 522373007929 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 522373007930 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 522373007931 potential catalytic triad [active] 522373007932 conserved cys residue [active] 522373007933 1 probable transmembrane helix predicted for Smlt2081 by TMHMM2.0 at aa 7-29 522373007934 HMMPfam hit to PF01965, DJ-1/PfpI family, score 1.8e-18 522373007935 1 probable transmembrane helix predicted for Smlt2082 by TMHMM2.0 at aa 246-268 522373007936 1 probable transmembrane helix predicted for Smlt2083 by TMHMM2.0 at aa 10-29 522373007937 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 522373007938 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 522373007939 NAD binding site [chemical binding]; other site 522373007940 homotetramer interface [polypeptide binding]; other site 522373007941 homodimer interface [polypeptide binding]; other site 522373007942 substrate binding site [chemical binding]; other site 522373007943 active site 522373007944 HMMPfam hit to PF00106, short chain dehydrogenase, score 1e-33 522373007945 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 522373007946 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 522373007947 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 522373007948 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 522373007949 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 522373007950 HMMPfam hit to PF03988, Repeat of Unknown Function (DUF347), score 2e-16 522373007951 8 probable transmembrane helices predicted for Smlt2085 by TMHMM2.0 at aa 13-30, 40-62, 74-93, 97-119, 139-158, 163-185, 192-214 and 224-243 522373007952 HMMPfam hit to PF03988, Repeat of Unknown Function (DUF347), score 3.1e-06 522373007953 HMMPfam hit to PF03988, Repeat of Unknown Function (DUF347), score 2.3e-05 522373007954 HMMPfam hit to PF03988, Repeat of Unknown Function (DUF347), score 1.6e-06 522373007955 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 522373007956 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 522373007957 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373007958 5 probable transmembrane helices predicted for Smlt2088 by TMHMM2.0 at aa 23-45, 58-80, 119-136, 156-178 and 206-228 522373007959 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 522373007960 putative hydrophobic ligand binding site [chemical binding]; other site 522373007961 HMMPfam hit to PF08327, Activator of Hsp90 ATPase homolog 1-like pro, score 4.4e-09 522373007962 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373007963 dimerization interface [polypeptide binding]; other site 522373007964 putative DNA binding site [nucleotide binding]; other site 522373007965 putative Zn2+ binding site [ion binding]; other site 522373007966 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 1.1e-07 522373007967 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 522373007968 putative hydrophobic ligand binding site [chemical binding]; other site 522373007969 HMMPfam hit to PF08327, Activator of Hsp90 ATPase homolog 1-like pro, score 0.00012 522373007970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373007971 Coenzyme A binding pocket [chemical binding]; other site 522373007972 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.1e-11 522373007973 myosin-cross-reactive antigen; Provisional; Region: PRK13977 522373007974 HMMPfam hit to PF06100, Streptococcal 67 kDa myosin-cross-rea, score 0 522373007975 1 probable transmembrane helix predicted for Smlt2093 by TMHMM2.0 at aa 25-42 522373007976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373007977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373007978 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 9.6e-14 522373007979 5 probable transmembrane helices predicted for Smlt2095 by TMHMM2.0 at aa 35-57, 70-92, 96-118, 125-142 and 157-179 522373007980 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 522373007981 HMMPfam hit to PF01584, CheW-like domain, score 2.5e-09 522373007982 Sensors of blue-light using FAD; Region: BLUF; pfam04940 522373007983 HMMPfam hit to PF04940, Sensors of blue-light using FAD, score 3.5e-10 522373007984 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 522373007985 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 522373007986 conserved cys residue [active] 522373007987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373007988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373007989 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix prote, score 2.7e-07 522373007990 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix prote, score 1.4e-07 522373007991 HMMPfam hit to PF01965, DJ-1/PfpI family, score 2.2e-19 522373007992 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373007993 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373007994 N-terminal plug; other site 522373007995 ligand-binding site [chemical binding]; other site 522373007996 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 6.3e-17 522373007997 HMMPfam hit to PF00593, TonB dependent receptor, score 8.5e-19 522373007998 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373007999 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 522373008000 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 4.2e-07 522373008001 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 522373008002 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 522373008003 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 522373008004 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 1.5e-09 522373008005 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 522373008006 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 522373008007 active site 522373008008 non-prolyl cis peptide bond; other site 522373008009 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 522373008010 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 522373008011 metal binding site [ion binding]; metal-binding site 522373008012 putative dimer interface [polypeptide binding]; other site 522373008013 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 2e-67 522373008014 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 1.1e-11 522373008015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373008016 Coenzyme A binding pocket [chemical binding]; other site 522373008017 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.8e-16 522373008018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373008019 dimer interface [polypeptide binding]; other site 522373008020 conserved gate region; other site 522373008021 putative PBP binding loops; other site 522373008022 ABC-ATPase subunit interface; other site 522373008023 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 522373008024 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 522373008025 Walker A/P-loop; other site 522373008026 ATP binding site [chemical binding]; other site 522373008027 Q-loop/lid; other site 522373008028 ABC transporter signature motif; other site 522373008029 Walker B; other site 522373008030 D-loop; other site 522373008031 H-loop/switch region; other site 522373008032 6 probable transmembrane helices predicted for Smlt2106 by TMHMM2.0 at aa 30-52, 73-95, 110-132, 144-166, 226-248 and 255-277 522373008033 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.9e-22 522373008034 HMMPfam hit to PF00005, ABC transporter score 1.1e-71 522373008035 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 522373008036 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 522373008037 substrate binding pocket [chemical binding]; other site 522373008038 membrane-bound complex binding site; other site 522373008039 hinge residues; other site 522373008040 1 probable transmembrane helix predicted for Smlt2107 by TMHMM2.0 at aa 12-29 522373008041 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.5e-28 522373008042 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 522373008043 HMMPfam hit to PF00754, F5/8 type C domain, score 2.7e-22 522373008044 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 522373008045 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 522373008046 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 522373008047 1 probable transmembrane helix predicted for Smlt2111 by TMHMM2.0 at aa 23-45 522373008048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373008049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373008050 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 522373008051 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2.6e-20 522373008052 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373008053 HMMPfam hit to PF00563, EAL domain, score 1.5e-48 522373008054 4 probable transmembrane helices predicted for Smlt2113 by TMHMM2.0 at aa 21-43, 58-80, 124-146 and 156-178 522373008055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373008056 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 522373008057 putative effector binding pocket; other site 522373008058 putative dimerization interface [polypeptide binding]; other site 522373008059 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-51 522373008060 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.8e-18 522373008061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373008062 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 522373008063 14 probable transmembrane helices predicted for Smlt2115 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 111-133, 140-162, 166-188, 201-223, 228-250, 270-292, 305-327, 334-356, 361-383, 395-417 and 468-490 522373008064 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.6e-47 522373008065 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 522373008066 classical (c) SDRs; Region: SDR_c; cd05233 522373008067 NAD(P) binding site [chemical binding]; other site 522373008068 active site 522373008069 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.0028 522373008070 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.7e-06 522373008071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373008072 Coenzyme A binding pocket [chemical binding]; other site 522373008073 HMMPfam hit to PF08445, FR47-like protein, score 0.00029 522373008074 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 0.0002 522373008075 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373008076 dimerization interface [polypeptide binding]; other site 522373008077 putative DNA binding site [nucleotide binding]; other site 522373008078 putative Zn2+ binding site [ion binding]; other site 522373008079 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 522373008080 active site residue [active] 522373008081 HMMPfam hit to PF00581, Rhodanese-like domain, score 7.3e-12 522373008082 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 1.3e-07 522373008083 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 522373008084 4 probable transmembrane helices predicted for Smlt2119 by TMHMM2.0 at aa 10-32, 76-98, 113-135 and 148-170 522373008085 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 522373008086 active site 522373008087 ATP binding site [chemical binding]; other site 522373008088 Phosphotransferase enzyme family; Region: APH; pfam01636 522373008089 antibiotic binding site [chemical binding]; other site 522373008090 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 4.5e-46 522373008091 4 probable transmembrane helices predicted for Smlt2121 by TMHMM2.0 at aa 30-52, 67-89, 94-116 and 126-148 522373008092 HMMPfam hit to PF07681, DoxX, score 5.9e-22 522373008093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373008094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373008095 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 522373008096 8 probable transmembrane helices predicted for Smlt2124 by TMHMM2.0 at aa 13-35, 95-117, 124-141, 168-190, 203-222, 237-259, 279-298 and 308-330 522373008097 Phosphotransferase enzyme family; Region: APH; pfam01636 522373008098 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 522373008099 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 6.5e-14 522373008100 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 522373008101 EamA-like transporter family; Region: EamA; pfam00892 522373008102 EamA-like transporter family; Region: EamA; cl17759 522373008103 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.7e-11 522373008104 9 probable transmembrane helices predicted for Smlt2126 by TMHMM2.0 at aa 15-37, 78-97, 102-124, 129-146, 150-172, 185-207, 212-231, 240-262 and 266-285 522373008105 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 9.5e-22 522373008106 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 522373008107 FAD binding domain; Region: FAD_binding_4; pfam01565 522373008108 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 522373008109 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine red, score 2.6e-33 522373008110 HMMPfam hit to PF01565, FAD binding domain, score 7.2e-12 522373008111 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 522373008112 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 522373008113 quinone interaction residues [chemical binding]; other site 522373008114 active site 522373008115 catalytic residues [active] 522373008116 FMN binding site [chemical binding]; other site 522373008117 substrate binding site [chemical binding]; other site 522373008118 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, score 1.3e-105 522373008119 Methyltransferase domain; Region: Methyltransf_11; pfam08241 522373008120 HMMPfam hit to PF08241, Methyltransferase domain, score 1.5e-19 522373008121 HMMPfam hit to PF08242, Methyltransferase domain, score 2e-09 522373008122 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 522373008123 2 probable transmembrane helices predicted for Smlt2130 by TMHMM2.0 at aa 77-99 and 120-154 522373008124 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 522373008125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373008126 NAD(P) binding site [chemical binding]; other site 522373008127 active site 522373008128 HMMPfam hit to PF00106, short chain dehydrogenase, score 8.2e-16 522373008129 aldehyde dehydrogenase family 7 member; Region: PLN02315 522373008130 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 522373008131 tetrameric interface [polypeptide binding]; other site 522373008132 NAD binding site [chemical binding]; other site 522373008133 catalytic residues [active] 522373008134 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 2.2e-149 522373008135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 522373008136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373008137 Coenzyme A binding pocket [chemical binding]; other site 522373008138 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.8e-17 522373008139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 522373008140 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 522373008141 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.9e-05 522373008142 Helix-turn-helix domain; Region: HTH_18; pfam12833 522373008143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373008144 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.7e-06 522373008145 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 522373008146 Ligand Binding Site [chemical binding]; other site 522373008147 HMMPfam hit to PF00582, Universal stress protein family, score 1e-14 522373008148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373008149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008150 active site 522373008151 phosphorylation site [posttranslational modification] 522373008152 intermolecular recognition site; other site 522373008153 HMMPfam hit to PF00072, Response regulator receiver domain, score 8e-18 522373008154 PAS domain S-box; Region: sensory_box; TIGR00229 522373008155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373008156 putative active site [active] 522373008157 histidine kinase; Provisional; Region: PRK13557 522373008158 heme pocket [chemical binding]; other site 522373008159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373008160 ATP binding site [chemical binding]; other site 522373008161 G-X-G motif; other site 522373008162 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 8.4e-27 522373008163 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.5e-08 522373008164 HMMPfam hit to PF08448, PAS fold, score 0.00043 522373008165 HMMPfam hit to PF08447, PAS fold, score 0.0016 522373008166 HMMPfam hit to PF00989, PAS fold, score 2.8e-08 522373008167 GAF domain; Region: GAF_3; pfam13492 522373008168 GAF domain; Region: GAF_2; pfam13185 522373008169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373008170 dimer interface [polypeptide binding]; other site 522373008171 phosphorylation site [posttranslational modification] 522373008172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373008173 ATP binding site [chemical binding]; other site 522373008174 Mg2+ binding site [ion binding]; other site 522373008175 G-X-G motif; other site 522373008176 Response regulator receiver domain; Region: Response_reg; pfam00072 522373008177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008178 active site 522373008179 phosphorylation site [posttranslational modification] 522373008180 intermolecular recognition site; other site 522373008181 dimerization interface [polypeptide binding]; other site 522373008182 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373008183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008184 active site 522373008185 phosphorylation site [posttranslational modification] 522373008186 intermolecular recognition site; other site 522373008187 dimerization interface [polypeptide binding]; other site 522373008188 Response regulator receiver domain; Region: Response_reg; pfam00072 522373008189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008190 active site 522373008191 phosphorylation site [posttranslational modification] 522373008192 intermolecular recognition site; other site 522373008193 dimerization interface [polypeptide binding]; other site 522373008194 3 probable transmembrane helices predicted for Smlt2141 by TMHMM2.0 at aa 17-39, 54-76 and 83-105 522373008195 HMMPfam hit to PF01590, GAF domain, score 1.4e-08 522373008196 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 8.6e-23 522373008197 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 3.5e-45 522373008198 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.3e-19 522373008199 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.7e-09 522373008200 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.9e-31 522373008201 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 522373008202 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 522373008203 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 522373008204 HMMPfam hit to PF03705, CheR methyltransferase, all-alpha domain, score 3.7e-09 522373008205 HMMPfam hit to PF01739, CheR methyltransferase, SAM binding domain, score 1.3e-32 522373008206 CheB methylesterase; Region: CheB_methylest; pfam01339 522373008207 HMMPfam hit to PF01339, CheB methylesterase, score 1.3e-28 522373008208 Response regulator receiver domain; Region: Response_reg; pfam00072 522373008209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008210 active site 522373008211 phosphorylation site [posttranslational modification] 522373008212 intermolecular recognition site; other site 522373008213 dimerization interface [polypeptide binding]; other site 522373008214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373008215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373008216 dimer interface [polypeptide binding]; other site 522373008217 phosphorylation site [posttranslational modification] 522373008218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373008219 ATP binding site [chemical binding]; other site 522373008220 Mg2+ binding site [ion binding]; other site 522373008221 G-X-G motif; other site 522373008222 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-26 522373008223 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.6e-16 522373008224 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 7.1e-21 522373008225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373008226 dimerization interface [polypeptide binding]; other site 522373008227 putative DNA binding site [nucleotide binding]; other site 522373008228 putative Zn2+ binding site [ion binding]; other site 522373008229 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 2.8e-10 522373008230 Predicted transporter component [General function prediction only]; Region: COG2391 522373008231 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 522373008232 4 probable transmembrane helices predicted for Smlt2149 by TMHMM2.0 at aa 4-26, 47-69, 84-101 and 121-143 522373008233 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 5.5e-16 522373008234 Predicted transporter component [General function prediction only]; Region: COG2391 522373008235 Sulphur transport; Region: Sulf_transp; pfam04143 522373008236 4 probable transmembrane helices predicted for Smlt2150 by TMHMM2.0 at aa 5-24, 44-63, 84-103 and 108-130 522373008237 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 1.6e-10 522373008238 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 522373008239 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 522373008240 1 probable transmembrane helix predicted for Smlt2151 by TMHMM2.0 at aa 12-31 522373008241 HMMPfam hit to PF02275, Linear amide C-N hydrolases, choloylglycine, score 3.6e-36 522373008242 HMMPfam hit to PF03417, Acyl-coenzyme A:6-aminopenicillanic acid acy, score 0.0046 522373008243 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 522373008244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373008245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373008246 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.9e-05 522373008247 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.1e-07 522373008248 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 522373008249 10 probable transmembrane helices predicted for Smlt2154 by TMHMM2.0 at aa 67-89, 99-118, 130-152, 156-175, 187-206, 219-241, 254-276, 286-308, 315-337 and 342-364 522373008250 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.1e-08 522373008251 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 522373008252 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 522373008253 putative catalytic residues [active] 522373008254 putative nucleotide binding site [chemical binding]; other site 522373008255 putative aspartate binding site [chemical binding]; other site 522373008256 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 522373008257 dimer interface [polypeptide binding]; other site 522373008258 putative threonine allosteric regulatory site; other site 522373008259 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 522373008260 putative threonine allosteric regulatory site; other site 522373008261 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 522373008262 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 522373008263 HMMPfam hit to PF00696, Amino acid kinase family, score 3.5e-53 522373008264 HMMPfam hit to PF01842, ACT domain, score 2.9e-05 522373008265 HMMPfam hit to PF01842, ACT domain, score 1.5e-07 522373008266 HMMPfam hit to PF03447, Homoserine dehydrogenase, NAD binding d, score 1.2e-29 522373008267 HMMPfam hit to PF00742, Homoserine dehydrogenase, score 8.5e-79 522373008268 homoserine kinase; Provisional; Region: PRK01212 522373008269 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 522373008270 HMMPfam hit to PF00288, GHMP kinases N terminal domain, score 1.9e-17 522373008271 HMMPfam hit to PF08544, GHMP kinases C terminal, score 6.7e-08 522373008272 threonine synthase; Validated; Region: PRK09225 522373008273 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 522373008274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373008275 catalytic residue [active] 522373008276 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.9e-10 522373008277 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 522373008278 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 522373008279 ligand binding site [chemical binding]; other site 522373008280 flexible hinge region; other site 522373008281 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 522373008282 putative switch regulator; other site 522373008283 non-specific DNA interactions [nucleotide binding]; other site 522373008284 DNA binding site [nucleotide binding] 522373008285 sequence specific DNA binding site [nucleotide binding]; other site 522373008286 putative cAMP binding site [chemical binding]; other site 522373008287 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 2e-15 522373008288 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 7.6e-12 522373008289 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 522373008290 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 522373008291 dimer interface [polypeptide binding]; other site 522373008292 motif 1; other site 522373008293 active site 522373008294 motif 2; other site 522373008295 motif 3; other site 522373008296 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 522373008297 anticodon binding site; other site 522373008298 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 8e-32 522373008299 HMMPfam hit to PF03129, Anticodon binding domain, score 2.4e-16 522373008300 Trp repressor protein; Region: Trp_repressor; cl17266 522373008301 HMMPfam hit to PF01371, Trp repressor protein, score 7.2e-34 522373008302 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 522373008303 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 522373008304 HisG, C-terminal domain; Region: HisG_C; cl06867 522373008305 HMMPfam hit to PF01634, ATP phosphoribosyltransferase, score 1.1e-57 522373008306 HMMPfam hit to PF08029, HisG, C-terminal domain, score 2.1e-09 522373008307 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 522373008308 histidinol dehydrogenase; Region: hisD; TIGR00069 522373008309 NAD binding site [chemical binding]; other site 522373008310 dimerization interface [polypeptide binding]; other site 522373008311 product binding site; other site 522373008312 substrate binding site [chemical binding]; other site 522373008313 zinc binding site [ion binding]; other site 522373008314 catalytic residues [active] 522373008315 HMMPfam hit to PF00815, Histidinol dehydrogenase, score 1.6e-220 522373008316 histidinol-phosphate aminotransferase; Provisional; Region: PRK04781 522373008317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373008318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373008319 homodimer interface [polypeptide binding]; other site 522373008320 catalytic residue [active] 522373008321 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.9e-52 522373008322 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 522373008323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373008324 active site 522373008325 motif I; other site 522373008326 motif II; other site 522373008327 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 522373008328 putative active site pocket [active] 522373008329 4-fold oligomerization interface [polypeptide binding]; other site 522373008330 metal binding residues [ion binding]; metal-binding site 522373008331 3-fold/trimer interface [polypeptide binding]; other site 522373008332 HMMPfam hit to PF00475, Imidazoleglycerol-phosphate dehydratase, score 1e-91 522373008333 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 522373008334 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 522373008335 putative active site [active] 522373008336 oxyanion strand; other site 522373008337 catalytic triad [active] 522373008338 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.3e-37 522373008339 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 522373008340 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 522373008341 catalytic residues [active] 522373008342 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 3.7e-94 522373008343 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 522373008344 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 522373008345 substrate binding site [chemical binding]; other site 522373008346 glutamase interaction surface [polypeptide binding]; other site 522373008347 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 6.5e-100 522373008348 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 522373008349 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 522373008350 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 522373008351 metal binding site [ion binding]; metal-binding site 522373008352 HMMPfam hit to PF01502, Phosphoribosyl-AMP cyclohydrolase, score 2.6e-39 522373008353 HMMPfam hit to PF01503, Phosphoribosyl-ATP pyrophosphohydrolase, score 2.5e-36 522373008354 Cna protein B-type domain; Region: Cna_B_2; pfam13715 522373008355 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 522373008356 active site 522373008357 metal binding site [ion binding]; metal-binding site 522373008358 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 522373008359 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 522373008360 active site 522373008361 metal binding site [ion binding]; metal-binding site 522373008362 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 8.7e-05 522373008363 glucokinase; Provisional; Region: PRK12408 522373008364 glucokinase, proteobacterial type; Region: glk; TIGR00749 522373008365 HMMPfam hit to PF02685, Glucokinase, score 1e-92 522373008366 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 522373008367 active site 522373008368 dimer interface [polypeptide binding]; other site 522373008369 catalytic nucleophile [active] 522373008370 HMMPfam hit to PF01112, Asparaginase, score 2.8e-104 522373008371 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 522373008372 HMMPfam hit to PF03932, CutC family, score 6e-94 522373008373 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373008374 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373008375 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.3e-19 522373008376 HMMPfam hit to PF00593, TonB dependent receptor, score 9.9e-24 522373008377 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 522373008378 metal-binding site [ion binding] 522373008379 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 522373008380 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 522373008381 metal-binding site [ion binding] 522373008382 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 522373008383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373008384 motif II; other site 522373008385 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1.8e-15 522373008386 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 2.4e-18 522373008387 8 probable transmembrane helices predicted for Smlt2176 by TMHMM2.0 at aa 204-226, 231-253, 274-296, 306-324, 458-480, 485-507, 802-824 and 829-851 522373008388 HMMPfam hit to PF00122, E1-E2 ATPase, score 7.1e-101 522373008389 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 9.4e-39 522373008390 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 522373008391 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 522373008392 DNA binding residues [nucleotide binding] 522373008393 dimer interface [polypeptide binding]; other site 522373008394 copper binding site [ion binding]; other site 522373008395 HMMPfam hit to PF00376, MerR family regulatory protein, score 1e-13 522373008396 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 522373008397 metal-binding site [ion binding] 522373008398 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1.2e-05 522373008399 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 522373008400 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373008401 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373008402 HMMPfam hit to PF00593, TonB dependent receptor, score 1.2e-24 522373008403 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.2e-19 522373008404 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 522373008405 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 522373008406 HMMPfam hit to PF07971, Glycosyl hydrolase family, score 3.9e-228 522373008407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 522373008408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 522373008409 DNA binding site [nucleotide binding] 522373008410 domain linker motif; other site 522373008411 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 522373008412 putative ligand binding site [chemical binding]; other site 522373008413 putative dimerization interface [polypeptide binding]; other site 522373008414 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.3e-05 522373008415 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.3e-24 522373008416 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 522373008417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373008418 putative substrate translocation pore; other site 522373008419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373008420 12 probable transmembrane helices predicted for Smlt2182 by TMHMM2.0 at aa 24-46, 61-83, 90-109, 114-136, 157-179, 203-225, 254-276, 296-315, 322-339, 344-366, 378-400 and 404-426 522373008421 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-16 522373008422 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 522373008423 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 522373008424 putative substrate binding site [chemical binding]; other site 522373008425 putative ATP binding site [chemical binding]; other site 522373008426 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 5.1e-59 522373008427 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 522373008428 dimerization interface [polypeptide binding]; other site 522373008429 putative active cleft [active] 522373008430 HMMPfam hit to PF07221, N-acylglucosamine 2-epimerase (GlcNAc, score 7.8e-180 522373008431 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 522373008432 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 522373008433 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 522373008434 1 probable transmembrane helix predicted for Smlt2185 by TMHMM2.0 at aa 33-55 522373008435 HMMPfam hit to PF02837, Glycosyl hydrolases family 2, sugar b, score 0.0038 522373008436 HMMPfam hit to PF00703, Glycosyl hydrolases family 2, immunog, score 0.0039 522373008437 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 522373008438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373008439 motif I; other site 522373008440 motif II; other site 522373008441 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 7.2e-10 522373008442 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 522373008443 Cupin domain; Region: Cupin_2; cl17218 522373008444 HMMPfam hit to PF03079, ARD/ARD' family, score 1e-41 522373008445 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 522373008446 intersubunit interface [polypeptide binding]; other site 522373008447 active site 522373008448 Zn2+ binding site [ion binding]; other site 522373008449 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 1.9e-31 522373008450 1 probable transmembrane helix predicted for Smlt2190 by TMHMM2.0 at aa 40-62 522373008451 1 probable transmembrane helix predicted for Smlt2191 by TMHMM2.0 at aa 46-68 522373008452 amino acid transporter; Region: 2A0306; TIGR00909 522373008453 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 522373008454 HMMPfam hit to PF00324, Amino acid permease, score 3.1e-21 522373008455 12 probable transmembrane helices predicted for Smlt2192 by TMHMM2.0 at aa 28-50, 60-82, 103-125, 159-181, 188-210, 232-254, 266-288, 313-335, 365-387, 392-409, 422-444 and 448-467 522373008456 amino acid transporter; Region: 2A0306; TIGR00909 522373008457 HMMPfam hit to PF00324, Amino acid permease, score 8.7e-31 522373008458 12 probable transmembrane helices predicted for Smlt2193 by TMHMM2.0 at aa 41-63, 73-95, 116-138, 176-195, 200-222, 248-270, 283-305, 325-347, 379-401, 405-424, 437-456 and 460-482 522373008459 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 522373008460 nudix motif; other site 522373008461 HMMPfam hit to PF00293, NUDIX domain, score 1.5e-08 522373008462 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 522373008463 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 522373008464 ligand binding site [chemical binding]; other site 522373008465 NAD binding site [chemical binding]; other site 522373008466 tetramer interface [polypeptide binding]; other site 522373008467 catalytic site [active] 522373008468 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 522373008469 L-serine binding site [chemical binding]; other site 522373008470 ACT domain interface; other site 522373008471 HMMPfam hit to PF01842, ACT domain, score 5.6e-09 522373008472 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 1e-37 522373008473 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 1.9e-70 522373008474 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 522373008475 FAD binding domain; Region: FAD_binding_4; pfam01565 522373008476 HMMPfam hit to PF01565, FAD binding domain, score 6.5e-53 522373008477 HMMPfam hit to PF02913, FAD linked oxidases, C-terminal domain, score 3.5e-84 522373008478 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 522373008479 1 probable transmembrane helix predicted for Smlt2197 by TMHMM2.0 at aa 27-49 522373008480 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 522373008481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373008482 HAMP domain; Region: HAMP; pfam00672 522373008483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373008484 dimer interface [polypeptide binding]; other site 522373008485 phosphorylation site [posttranslational modification] 522373008486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373008487 ATP binding site [chemical binding]; other site 522373008488 Mg2+ binding site [ion binding]; other site 522373008489 G-X-G motif; other site 522373008490 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.4e-40 522373008491 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.5e-09 522373008492 HMMPfam hit to PF00672, HAMP domain, score 5e-14 522373008493 2 probable transmembrane helices predicted for Smlt2199 by TMHMM2.0 at aa 13-35 and 60-82 522373008494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373008495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008496 active site 522373008497 phosphorylation site [posttranslational modification] 522373008498 intermolecular recognition site; other site 522373008499 dimerization interface [polypeptide binding]; other site 522373008500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373008501 DNA binding site [nucleotide binding] 522373008502 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.8e-12 522373008503 HMMPfam hit to PF00072, Response regulator receiver domain, score 2e-36 522373008504 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 522373008505 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373008506 HMMPfam hit to PF00529, HlyD family secretion protein, score 9.4e-50 522373008507 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 522373008508 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373008509 12 probable transmembrane helices predicted for Smlt2202 by TMHMM2.0 at aa 9-31, 340-359, 366-388, 392-414, 438-460, 475-497, 539-561, 866-885, 892-914, 919-941, 962-984 and 999-1021 522373008510 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 522373008511 Predicted membrane protein [Function unknown]; Region: COG3650 522373008512 elongation factor P; Provisional; Region: PRK04542 522373008513 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 522373008514 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 522373008515 RNA binding site [nucleotide binding]; other site 522373008516 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 522373008517 RNA binding site [nucleotide binding]; other site 522373008518 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 4.1e-15 522373008519 HMMPfam hit to PF08207, Elongation factor P (EF-P) KOW-like domain, score 0.00047 522373008520 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 522373008521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373008522 NAD(P) binding site [chemical binding]; other site 522373008523 active site 522373008524 HMMPfam hit to PF00106, short chain dehydrogenase, score 5.4e-14 522373008525 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 522373008526 active site 522373008527 catalytic residues [active] 522373008528 metal binding site [ion binding]; metal-binding site 522373008529 HMMPfam hit to PF00682, HMGL-like, score 3.1e-72 522373008530 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 522373008531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373008532 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 2.3e-08 522373008533 enoyl-CoA hydratase; Provisional; Region: PRK05995 522373008534 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 522373008535 substrate binding site [chemical binding]; other site 522373008536 oxyanion hole (OAH) forming residues; other site 522373008537 trimer interface [polypeptide binding]; other site 522373008538 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 3.8e-47 522373008539 FeoA domain; Region: FeoA; pfam04023 522373008540 HMMPfam hit to PF04023, FeoA domain, score 9.9e-20 522373008541 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 522373008542 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 522373008543 G1 box; other site 522373008544 GTP/Mg2+ binding site [chemical binding]; other site 522373008545 Switch I region; other site 522373008546 G2 box; other site 522373008547 G3 box; other site 522373008548 Switch II region; other site 522373008549 G4 box; other site 522373008550 G5 box; other site 522373008551 Nucleoside recognition; Region: Gate; pfam07670 522373008552 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 522373008553 Nucleoside recognition; Region: Gate; pfam07670 522373008554 HMMPfam hit to PF01926, GTPase of unknown function, score 1.5e-28 522373008555 HMMPfam hit to PF02421, Ferrous iron transport protein B, score 1.3e-40 522373008556 11 probable transmembrane helices predicted for Smlt2211 by TMHMM2.0 at aa 219-241, 254-276, 281-303, 323-345, 358-380, 395-417, 460-482, 497-519, 521-540, 560-582 and 595-617 522373008557 HMMPfam hit to PF07670, Nucleoside recognition, score 5.9e-15 522373008558 HMMPfam hit to PF07664, Ferrous iron transport protein B C terminus, score 1.2e-21 522373008559 HMMPfam hit to PF07670, Nucleoside recognition, score 2.1e-15 522373008560 1 probable transmembrane helix predicted for Smlt2212 by TMHMM2.0 at aa 5-24 522373008561 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 522373008562 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 522373008563 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373008564 HMMPfam hit to PF02525, Flavodoxin-like fold, score 1.3e-11 522373008565 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 0.0012 522373008566 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 522373008567 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 522373008568 DNA binding residues [nucleotide binding] 522373008569 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.1e-10 522373008570 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 522373008571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373008572 NAD(P) binding site [chemical binding]; other site 522373008573 active site 522373008574 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.6e-09 522373008575 dihydrodipicolinate reductase; Provisional; Region: PRK00048 522373008576 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 522373008577 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 522373008578 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, N-terminus, score 2.2e-33 522373008579 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, C-terminus, score 9.4e-48 522373008580 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 522373008581 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 522373008582 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 522373008583 catalytic site [active] 522373008584 subunit interface [polypeptide binding]; other site 522373008585 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase small ch, score 4e-81 522373008586 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.1e-64 522373008587 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 522373008588 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 522373008589 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 522373008590 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 522373008591 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 522373008592 ATP-grasp domain; Region: ATP-grasp_4; cl17255 522373008593 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 522373008594 IMP binding site; other site 522373008595 dimer interface [polypeptide binding]; other site 522373008596 interdomain contacts; other site 522373008597 partial ornithine binding site; other site 522373008598 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 1.1e-58 522373008599 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 4.5e-128 522373008600 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large c, score 7.5e-61 522373008601 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 2.1e-26 522373008602 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 6.7e-34 522373008603 HMMPfam hit to PF02222, ATP-grasp domain, score 0.0006 522373008604 HMMPfam hit to PF02142, MGS-like domain, score 2.4e-32 522373008605 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 522373008606 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 522373008607 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 522373008608 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 5.2e-42 522373008609 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 3.9e-28 522373008610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 522373008611 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 522373008612 HMMPfam hit to PF06674, Protein of unknown function (DUF1176), score 5.1e-70 522373008613 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 522373008614 DHH family; Region: DHH; pfam01368 522373008615 DHHA1 domain; Region: DHHA1; pfam02272 522373008616 HMMPfam hit to PF01368, DHH family, score 2.8e-50 522373008617 HMMPfam hit to PF02272, DHHA1 domain, score 7e-15 522373008618 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 522373008619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 522373008620 binding surface 522373008621 TPR motif; other site 522373008622 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 522373008623 HMMPfam hit to PF08487, Vault protein inter-alpha-trypsin, score 7.4e-07 522373008624 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 522373008625 10 probable transmembrane helices predicted for Smlt2225 by TMHMM2.0 at aa 64-83, 103-125, 137-159, 204-226, 233-255, 270-292, 304-326, 346-365, 378-400 and 405-427 522373008626 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 522373008627 LytTr DNA-binding domain; Region: LytTR; smart00850 522373008628 3 probable transmembrane helices predicted for Smlt2226 by TMHMM2.0 at aa 19-38, 53-75 and 88-110 522373008629 HMMPfam hit to PF04397, LytTr DNA-binding domain, score 9e-25 522373008630 putative peptide chain release factor 2, pseudogene;similarity:fasta; ECA0773; ecarotovora_atroseptica; putative peptide chain release factor 2; length 365 aa; id=69.9%; E()=1.7e-87; 296 aa overlap; query 4-299 aa; subject 70-365 aa; similarity:fasta; YE3376; yenterocolitica; peptide chain release factor 2; length 365 aa; id=70.6%; E()=2.5e-88; 293 aa overlap; query 8-299 aa; subject 73-365 aa; similarity:fasta; SBG2635; sbongori; peptide chain release factor 2 (RF-2); length 293 aa; id=71.0%; E()=6.3e-87; 290 aa overlap; query 10-299 aa; subject 4-293 aa; similarity:fasta; SEN2884; senteritidisPT4; peptide chain release factor 2 (RF-2); length 293 aa; id=71.0%; E()=8.6e-86; 290 aa overlap; query 10-299 aa; subject 4-293 aa 522373008631 HMMPfam hit to PF03462, PCRF domain, score 6e-56 522373008632 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 3.4e-70 522373008633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373008634 salt bridge; other site 522373008635 non-specific DNA binding site [nucleotide binding]; other site 522373008636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 522373008637 sequence-specific DNA binding site [nucleotide binding]; other site 522373008638 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 522373008639 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 522373008640 NAD(P) binding site [chemical binding]; other site 522373008641 catalytic residues [active] 522373008642 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 5.9e-151 522373008643 acetolactate synthase; Reviewed; Region: PRK08322 522373008644 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 522373008645 PYR/PP interface [polypeptide binding]; other site 522373008646 dimer interface [polypeptide binding]; other site 522373008647 TPP binding site [chemical binding]; other site 522373008648 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 522373008649 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 522373008650 TPP-binding site [chemical binding]; other site 522373008651 dimer interface [polypeptide binding]; other site 522373008652 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 2.9e-48 522373008653 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 4.1e-23 522373008654 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 3.9e-52 522373008655 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 522373008656 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 522373008657 dimer interface [polypeptide binding]; other site 522373008658 putative anticodon binding site; other site 522373008659 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 522373008660 motif 1; other site 522373008661 active site 522373008662 motif 2; other site 522373008663 motif 3; other site 522373008664 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.1e-19 522373008665 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 1.2e-127 522373008666 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 522373008667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008668 active site 522373008669 phosphorylation site [posttranslational modification] 522373008670 intermolecular recognition site; other site 522373008671 dimerization interface [polypeptide binding]; other site 522373008672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 522373008673 Zn2+ binding site [ion binding]; other site 522373008674 Mg2+ binding site [ion binding]; other site 522373008675 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-30 522373008676 HMMPfam hit to PF01966, HD domain, score 7.3e-28 522373008677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373008678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373008679 dimer interface [polypeptide binding]; other site 522373008680 phosphorylation site [posttranslational modification] 522373008681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373008682 ATP binding site [chemical binding]; other site 522373008683 Mg2+ binding site [ion binding]; other site 522373008684 G-X-G motif; other site 522373008685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008686 Response regulator receiver domain; Region: Response_reg; pfam00072 522373008687 active site 522373008688 phosphorylation site [posttranslational modification] 522373008689 intermolecular recognition site; other site 522373008690 dimerization interface [polypeptide binding]; other site 522373008691 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 522373008692 putative binding surface; other site 522373008693 active site 522373008694 10 probable transmembrane helices predicted for Smlt2234 by TMHMM2.0 at aa 4-21, 26-48, 68-90, 102-124, 128-150, 190-207, 217-239, 260-282, 292-314 and 319-341 522373008695 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1e-25 522373008696 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2.3e-31 522373008697 HMMPfam hit to PF00072, Response regulator receiver domain, score 3e-29 522373008698 HMMPfam hit to PF01627, Hpt domain, score 4.6e-07 522373008699 enoyl-CoA hydratase; Validated; Region: PRK08788 522373008700 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 522373008701 substrate binding site [chemical binding]; other site 522373008702 oxyanion hole (OAH) forming residues; other site 522373008703 trimer interface [polypeptide binding]; other site 522373008704 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 2.5e-11 522373008705 putative long-chain fatty acyl CoA ligase; Provisional; Region: PRK08751 522373008706 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 522373008707 acyl-activating enzyme (AAE) consensus motif; other site 522373008708 putative AMP binding site [chemical binding]; other site 522373008709 putative active site [active] 522373008710 putative CoA binding site [chemical binding]; other site 522373008711 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.9e-133 522373008712 choline dehydrogenase; Validated; Region: PRK02106 522373008713 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 522373008714 HMMPfam hit to PF05199, GMC oxidoreductase, score 6.5e-75 522373008715 HMMPfam hit to PF00732, GMC oxidoreductase, score 2.9e-146 522373008716 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 522373008717 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 522373008718 tetrameric interface [polypeptide binding]; other site 522373008719 NAD binding site [chemical binding]; other site 522373008720 catalytic residues [active] 522373008721 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 4.1e-240 522373008722 transcriptional regulator BetI; Validated; Region: PRK00767 522373008723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373008724 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 522373008725 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.2e-10 522373008726 BCCT family transporter; Region: BCCT; pfam02028 522373008727 12 probable transmembrane helices predicted for Smlt2240 by TMHMM2.0 at aa 17-36, 51-73, 94-116, 144-166, 197-219, 234-252, 264-286, 317-339, 352-371, 411-433, 454-476 and 481-503 522373008728 HMMPfam hit to PF02028, BCCT family transporter score 8.3e-192 522373008729 aconitate hydratase; Validated; Region: PRK09277 522373008730 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 522373008731 substrate binding site [chemical binding]; other site 522373008732 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 522373008733 ligand binding site [chemical binding]; other site 522373008734 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 522373008735 substrate binding site [chemical binding]; other site 522373008736 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 2.9e-58 522373008737 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 6.4e-202 522373008738 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 522373008739 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 522373008740 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 522373008741 HMMPfam hit to PF04014, SpoVT / AbrB like domain, score 2.6e-09 522373008742 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 522373008743 putative active site [active] 522373008744 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 522373008745 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 522373008746 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 522373008747 substrate binding site [chemical binding]; other site 522373008748 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 522373008749 substrate binding site [chemical binding]; other site 522373008750 ligand binding site [chemical binding]; other site 522373008751 HMMPfam hit to PF06434, Aconitate hydratase, score 5.9e-275 522373008752 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 1.8e-11 522373008753 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 522373008754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008755 active site 522373008756 phosphorylation site [posttranslational modification] 522373008757 intermolecular recognition site; other site 522373008758 dimerization interface [polypeptide binding]; other site 522373008759 CheB methylesterase; Region: CheB_methylest; pfam01339 522373008760 HMMPfam hit to PF01339, CheB methylesterase, score 2.1e-100 522373008761 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.4e-26 522373008762 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 522373008763 HMMPfam hit to PF03975, CheD, score 6.2e-40 522373008764 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 522373008765 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 522373008766 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 522373008767 HMMPfam hit to PF01739, CheR methyltransferase, SAM binding domain, score 6.2e-68 522373008768 HMMPfam hit to PF03705, CheR methyltransferase, all-alpha domain, score 2.9e-15 522373008769 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 522373008770 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 522373008771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 522373008772 dimerization interface [polypeptide binding]; other site 522373008773 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373008774 dimer interface [polypeptide binding]; other site 522373008775 putative CheW interface [polypeptide binding]; other site 522373008776 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 4.8e-100 522373008777 HMMPfam hit to PF00672, HAMP domain, score 1.4e-11 522373008778 2 probable transmembrane helices predicted for Smlt2251 by TMHMM2.0 at aa 20-39 and 194-216 522373008779 HMMPfam hit to PF08269, Cache domain, score 2e-16 522373008780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373008781 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373008782 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373008783 HMMPfam hit to PF01548, Transposase, score 1.8e-06 522373008784 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 4.3e-27 522373008785 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 522373008786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 522373008787 dimerization interface [polypeptide binding]; other site 522373008788 PAS domain; Region: PAS; smart00091 522373008789 PAS domain; Region: PAS_9; pfam13426 522373008790 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 522373008791 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373008792 dimer interface [polypeptide binding]; other site 522373008793 putative CheW interface [polypeptide binding]; other site 522373008794 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 8.2e-96 522373008795 HMMPfam hit to PF00672, HAMP domain, score 1e-13 522373008796 2 probable transmembrane helices predicted for Smlt2254 by TMHMM2.0 at aa 13-35 and 189-211 522373008797 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 522373008798 putative CheA interaction surface; other site 522373008799 HMMPfam hit to PF01584, CheW-like domain, score 1e-32 522373008800 Flagellar regulator YcgR; Region: YcgR; pfam07317 522373008801 PilZ domain; Region: PilZ; pfam07238 522373008802 HMMPfam hit to PF07238, PilZ domain, score 7.8e-08 522373008803 HMMPfam hit to PF07317, YcgR protein, score 1.2e-07 522373008804 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 522373008805 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 522373008806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373008807 dimer interface [polypeptide binding]; other site 522373008808 putative CheW interface [polypeptide binding]; other site 522373008809 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 9.1e-100 522373008810 HMMPfam hit to PF00672, HAMP domain, score 7.7e-09 522373008811 2 probable transmembrane helices predicted for Smlt2258 by TMHMM2.0 at aa 13-35 and 190-212 522373008812 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 522373008813 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 522373008814 putative binding surface; other site 522373008815 active site 522373008816 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 522373008817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373008818 ATP binding site [chemical binding]; other site 522373008819 Mg2+ binding site [ion binding]; other site 522373008820 G-X-G motif; other site 522373008821 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 522373008822 HMMPfam hit to PF01584, CheW-like domain, score 6e-28 522373008823 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 9.9e-26 522373008824 HMMPfam hit to PF02895, Signal transducing histidine kinase, hom, score 2.8e-22 522373008825 HMMPfam hit to PF01627, Hpt domain, score 5.5e-15 522373008826 Response regulator receiver domain; Region: Response_reg; pfam00072 522373008827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008828 active site 522373008829 phosphorylation site [posttranslational modification] 522373008830 intermolecular recognition site; other site 522373008831 dimerization interface [polypeptide binding]; other site 522373008832 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.1e-34 522373008833 STAS domain; Region: STAS_2; pfam13466 522373008834 CheW-like domain; Region: CheW; pfam01584 522373008835 HMMPfam hit to PF01584, CheW-like domain, score 9.2e-21 522373008836 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 522373008837 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 522373008838 P-loop; other site 522373008839 Magnesium ion binding site [ion binding]; other site 522373008840 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 522373008841 Magnesium ion binding site [ion binding]; other site 522373008842 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 9e-35 522373008843 flagellar motor protein MotD; Reviewed; Region: PRK09038 522373008844 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 522373008845 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 522373008846 ligand binding site [chemical binding]; other site 522373008847 HMMPfam hit to PF00691, OmpA family, score 9.5e-31 522373008848 1 probable transmembrane helix predicted for Smlt2265 by TMHMM2.0 at aa 16-38 522373008849 flagellar motor protein; Reviewed; Region: motC; PRK09109 522373008850 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 522373008851 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 2.3e-22 522373008852 4 probable transmembrane helices predicted for Smlt2266 by TMHMM2.0 at aa 7-29, 34-56, 145-167 and 182-204 522373008853 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 522373008854 putative binding surface; other site 522373008855 active site 522373008856 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 522373008857 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 522373008858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373008859 ATP binding site [chemical binding]; other site 522373008860 Mg2+ binding site [ion binding]; other site 522373008861 G-X-G motif; other site 522373008862 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 522373008863 HMMPfam hit to PF01584, CheW-like domain, score 1.8e-27 522373008864 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2.2e-30 522373008865 HMMPfam hit to PF02895, Signal transducing histidine kinase, hom, score 5e-16 522373008866 HMMPfam hit to PF01627, Hpt domain, score 1.8e-16 522373008867 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 522373008868 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 522373008869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008870 active site 522373008871 phosphorylation site [posttranslational modification] 522373008872 intermolecular recognition site; other site 522373008873 dimerization interface [polypeptide binding]; other site 522373008874 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-38 522373008875 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 522373008876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373008877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373008878 DNA binding residues [nucleotide binding] 522373008879 HMMPfam hit to PF04545, Sigma-70, region, score 1e-19 522373008880 HMMPfam hit to PF08281, Sigma-70, region, score 6.7e-08 522373008881 HMMPfam hit to PF04539, Sigma-70 region, score 5.9e-16 522373008882 HMMPfam hit to PF04542, Sigma-70 region, score 6.4e-20 522373008883 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 522373008884 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 522373008885 P-loop; other site 522373008886 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 3.2e-20 522373008887 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 522373008888 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 522373008889 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 522373008890 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 9.8e-31 522373008891 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 522373008892 FHIPEP family; Region: FHIPEP; pfam00771 522373008893 HMMPfam hit to PF00771, FHIPEP family, score 0 522373008894 7 probable transmembrane helices predicted for Smlt2273 by TMHMM2.0 at aa 21-43, 47-64, 76-98, 118-140, 213-235, 250-272 and 292-325 522373008895 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 522373008896 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 522373008897 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 2.9e-126 522373008898 4 probable transmembrane helices predicted for Smlt2274 by TMHMM2.0 at aa 36-58, 92-114, 153-172 and 192-211 522373008899 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 522373008900 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 522373008901 HMMPfam hit to PF02129, X-Pro dipeptidyl-peptidase (S15 family), score 1.7e-33 522373008902 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 522373008903 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 522373008904 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 522373008905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373008906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373008907 metal binding site [ion binding]; metal-binding site 522373008908 active site 522373008909 I-site; other site 522373008910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373008911 HMMPfam hit to PF00563, EAL domain, score 2.7e-127 522373008912 HMMPfam hit to PF00990, GGDEF domain, score 3.2e-58 522373008913 7 probable transmembrane helices predicted for Smlt2276 by TMHMM2.0 at aa 10-29, 42-64, 79-101, 108-130, 140-162, 174-196 and 216-238 522373008914 HMMPfam hit to PF03707, Bacterial signalling protein N terminal repe, score 4.3e-07 522373008915 HMMPfam hit to PF03707, Bacterial signalling protein N terminal repe, score 1.9e-18 522373008916 HMMPfam hit to PF03707, Bacterial signalling protein N terminal repe, score 1.2e-21 522373008917 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 522373008918 HMMPfam hit to PF01311, Bacterial export proteins, family, score 2.5e-37 522373008919 6 probable transmembrane helices predicted for Smlt2277 by TMHMM2.0 at aa 6-28, 41-60, 70-92, 128-150, 183-205 and 212-234 522373008920 HMMPfam hit to PF01313, Bacterial export proteins, family, score 8.2e-08 522373008921 2 probable transmembrane helices predicted for Smlt2278 by TMHMM2.0 at aa 15-37 and 49-71 522373008922 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 522373008923 6 probable transmembrane helices predicted for Smlt2279 by TMHMM2.0 at aa 13-35, 58-80, 101-118, 165-187, 199-221 and 236-258 522373008924 HMMPfam hit to PF00813, FliP family, score 2.1e-86 522373008925 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 522373008926 HMMPfam hit to PF04347, Flagellar biosynthesis protein, FliO, score 1.5e-22 522373008927 1 probable transmembrane helix predicted for Smlt2280 by TMHMM2.0 at aa 31-53 522373008928 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 522373008929 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 2.9e-32 522373008930 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 522373008931 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 522373008932 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 3.6e-05 522373008933 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 5e-102 522373008934 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 522373008935 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 1.7e-33 522373008936 1 probable transmembrane helix predicted for Smlt2283 by TMHMM2.0 at aa 24-46 522373008937 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 522373008938 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 1.6e-14 522373008939 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 522373008940 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 522373008941 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 522373008942 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 522373008943 Walker A motif/ATP binding site; other site 522373008944 Walker B motif; other site 522373008945 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 5e-120 522373008946 flagellar assembly protein H; Validated; Region: fliH; PRK05687 522373008947 Flagellar assembly protein FliH; Region: FliH; pfam02108 522373008948 HMMPfam hit to PF02108, Flagellar assembly protein FliH, score 3.3e-07 522373008949 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 522373008950 FliG C-terminal domain; Region: FliG_C; pfam01706 522373008951 HMMPfam hit to PF01706, FliG C-terminal domain, score 4.8e-47 522373008952 flagellar MS-ring protein; Reviewed; Region: fliF; PRK12800 522373008953 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 522373008954 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 522373008955 2 probable transmembrane helices predicted for Smlt2289 by TMHMM2.0 at aa 31-50 and 445-464 522373008956 HMMPfam hit to PF08345, Flagellar M-ring protein C-terminal, score 1.2e-74 522373008957 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 1.8e-64 522373008958 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 522373008959 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein Fl, score 2.9e-25 522373008960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373008961 Transposase; Region: HTH_Tnp_1; cl17663 522373008962 HMMPfam hit to PF01527, Transposase, score 0.00031 522373008963 putative transposase OrfB; Reviewed; Region: PHA02517 522373008964 HTH-like domain; Region: HTH_21; pfam13276 522373008965 Integrase core domain; Region: rve; pfam00665 522373008966 Integrase core domain; Region: rve_2; pfam13333 522373008967 HMMPfam hit to PF00665, Integrase core domain, score 1.9e-41 522373008968 1 probable transmembrane helix predicted for Smlt2293 by TMHMM2.0 at aa 15-34 522373008969 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 522373008970 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 522373008971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373008972 Walker A motif; other site 522373008973 ATP binding site [chemical binding]; other site 522373008974 Walker B motif; other site 522373008975 arginine finger; other site 522373008976 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 522373008977 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 1.9e-13 522373008978 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.4e-146 522373008979 HMMPfam hit to PF06490, Flagellar regulatory protein FleQ, score 1.3e-39 522373008980 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373008981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008982 active site 522373008983 phosphorylation site [posttranslational modification] 522373008984 intermolecular recognition site; other site 522373008985 HMMPfam hit to PF00072, Response regulator receiver domain, score 2e-24 522373008986 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 522373008987 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 522373008988 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 522373008989 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 522373008990 HMMPfam hit to PF04552, Sigma-54, DNA binding domain, score 1.6e-79 522373008991 HMMPfam hit to PF04963, Sigma-54 factor, core binding domain, score 1.2e-21 522373008992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373008993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373008994 active site 522373008995 phosphorylation site [posttranslational modification] 522373008996 intermolecular recognition site; other site 522373008997 dimerization interface [polypeptide binding]; other site 522373008998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373008999 DNA binding residues [nucleotide binding] 522373009000 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 1e-17 522373009001 HMMPfam hit to PF04545, Sigma-70, region, score 0.0022 522373009002 HMMPfam hit to PF08281, Sigma-70, region, score 3.7e-07 522373009003 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.4e-37 522373009004 flagellar protein FliS; Validated; Region: fliS; PRK05685 522373009005 HMMPfam hit to PF02561, Flagellar protein FliS, score 3.7e-25 522373009006 flagellar capping protein; Reviewed; Region: fliD; PRK08032 522373009007 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 522373009008 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 522373009009 HMMPfam hit to PF07195, Flagellar hook-associated protein, score 7.6e-54 522373009010 HMMPfam hit to PF07196, Flagellin hook IN motif, score 2e-06 522373009011 HMMPfam hit to PF02465, Flagellar hook-associated protein, score 1.2e-16 522373009012 flagellin; Reviewed; Region: PRK08869 522373009013 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 522373009014 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 522373009015 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 5.1e-33 522373009016 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 2.5e-64 522373009017 flagellin; Reviewed; Region: PRK08869 522373009018 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 522373009019 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 522373009020 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 2.9e-33 522373009021 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 2.5e-64 522373009022 flagellin; Reviewed; Region: PRK08869 522373009023 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 522373009024 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 522373009025 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 6.3e-36 522373009026 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 2.7e-70 522373009027 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 522373009028 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 522373009029 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 6.3e-05 522373009030 flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12714 522373009031 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 522373009032 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 522373009033 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 4.2e-19 522373009034 HMMPfam hit to PF00460, Flagella basal body rod protein, score 5e-08 522373009035 flagellar rod assembly protein/muramidase FlgJ; Reviewed; Region: flgJ; PRK12711 522373009036 Rod binding protein; Region: Rod-binding; pfam10135 522373009037 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 522373009038 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-ace, score 2.3e-37 522373009039 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 522373009040 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 522373009041 HMMPfam hit to PF02119, Flagellar P-ring protein, score 4.5e-203 522373009042 1 probable transmembrane helix predicted for Smlt2310 by TMHMM2.0 at aa 17-34 522373009043 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 522373009044 Flagellar L-ring protein; Region: FlgH; pfam02107 522373009045 HMMPfam hit to PF02107, Flagellar L-ring protein, score 2.2e-53 522373009046 1 probable transmembrane helix predicted for Smlt2311 by TMHMM2.0 at aa 7-29 522373009047 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 522373009048 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 522373009049 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 522373009050 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 4.3e-20 522373009051 HMMPfam hit to PF00460, Flagella basal body rod protein, score 2.1e-13 522373009052 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 522373009053 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 522373009054 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 522373009055 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 0.00056 522373009056 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1.6e-08 522373009057 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 522373009058 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 522373009059 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 522373009060 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 1e-18 522373009061 HMMPfam hit to PF07559, Flagellar basal body protein FlaE, score 3.2e-24 522373009062 HMMPfam hit to PF00460, Flagella basal body rod protein, score 9.5e-09 522373009063 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 522373009064 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634 522373009065 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 522373009066 HMMPfam hit to PF03963, Flagellar hook capping protein, score 9.6e-33 522373009067 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12629 522373009068 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 522373009069 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 522373009070 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 0.00021 522373009071 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12620 522373009072 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 522373009073 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1.6e-06 522373009074 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 522373009075 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373009076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373009077 active site 522373009078 phosphorylation site [posttranslational modification] 522373009079 intermolecular recognition site; other site 522373009080 dimerization interface [polypeptide binding]; other site 522373009081 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.7e-15 522373009082 HMMPfam hit to PF01584, CheW-like domain, score 5.5e-33 522373009083 SAF-like; Region: SAF_2; pfam13144 522373009084 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 522373009085 HMMPfam hit to PF03240, FlgA family, score 3e-24 522373009086 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 522373009087 FlgN protein; Region: FlgN; pfam05130 522373009088 HMMPfam hit to PF05130, FlgN protein, score 0.019 522373009089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 522373009090 dimer interface [polypeptide binding]; other site 522373009091 phosphorylation site [posttranslational modification] 522373009092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373009093 ATP binding site [chemical binding]; other site 522373009094 Mg2+ binding site [ion binding]; other site 522373009095 G-X-G motif; other site 522373009096 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.6e-36 522373009097 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373009098 metal binding site [ion binding]; metal-binding site 522373009099 active site 522373009100 I-site; other site 522373009101 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373009102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373009103 Response regulator receiver domain; Region: Response_reg; pfam00072 522373009104 active site 522373009105 phosphorylation site [posttranslational modification] 522373009106 intermolecular recognition site; other site 522373009107 dimerization interface [polypeptide binding]; other site 522373009108 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.3e-24 522373009109 HMMPfam hit to PF00563, EAL domain, score 2.8e-92 522373009110 HMMPfam hit to PF00990, GGDEF domain, score 5.6e-10 522373009111 PAS domain S-box; Region: sensory_box; TIGR00229 522373009112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373009113 putative active site [active] 522373009114 heme pocket [chemical binding]; other site 522373009115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373009116 PAS domain; Region: PAS_9; pfam13426 522373009117 putative active site [active] 522373009118 heme pocket [chemical binding]; other site 522373009119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 522373009120 Histidine kinase; Region: HisKA_3; pfam07730 522373009121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373009122 ATP binding site [chemical binding]; other site 522373009123 Mg2+ binding site [ion binding]; other site 522373009124 G-X-G motif; other site 522373009125 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 7.6e-18 522373009126 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.0057 522373009127 HMMPfam hit to PF00989, PAS fold, score 5.7e-08 522373009128 HMMPfam hit to PF00989, PAS fold, score 0.055 522373009129 HMMPfam hit to PF00989, PAS fold, score 3.2e-12 522373009130 PAS fold; Region: PAS_3; pfam08447 522373009131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373009132 heme pocket [chemical binding]; other site 522373009133 putative active site [active] 522373009134 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 522373009135 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373009136 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373009137 metal binding site [ion binding]; metal-binding site 522373009138 active site 522373009139 I-site; other site 522373009140 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373009141 HMMPfam hit to PF08447, PAS fold, score 8e-21 522373009142 HMMPfam hit to PF08447, PAS fold, score 0.0016 522373009143 HMMPfam hit to PF00990, GGDEF domain, score 7e-61 522373009144 HMMPfam hit to PF00563, EAL domain, score 6e-112 522373009145 3 probable transmembrane helices predicted for Smlt2326 by TMHMM2.0 at aa 5-27, 103-125 and 129-146 522373009146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373009147 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373009148 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373009149 HMMPfam hit to PF01548, Transposase, score 2.6e-10 522373009150 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 2e-24 522373009151 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 522373009152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373009153 dimer interface [polypeptide binding]; other site 522373009154 putative CheW interface [polypeptide binding]; other site 522373009155 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.5e-09 522373009156 1 probable transmembrane helix predicted for Smlt2330 by TMHMM2.0 at aa 12-34 522373009157 putative lysogenization regulator; Reviewed; Region: PRK00218 522373009158 HMMPfam hit to PF04356, Protein of unknown function (DUF489), score 1.6e-83 522373009159 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 522373009160 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 522373009161 HMMPfam hit to PF03054, tRNA methyl transferase, score 7.1e-174 522373009162 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 522373009163 nudix motif; other site 522373009164 HMMPfam hit to PF00293, NUDIX domain, score 1.2e-12 522373009165 Uncharacterized conserved protein [Function unknown]; Region: COG2127 522373009166 HMMPfam hit to PF02617, ATP-dependent Clp protease adaptor protein C, score 2.4e-41 522373009167 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 522373009168 HMMPfam hit to PF04655, Aminoglycoside/hydroxyurea antibiotic resis, score 7.1e-65 522373009169 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 522373009170 Clp amino terminal domain; Region: Clp_N; pfam02861 522373009171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373009172 Walker A motif; other site 522373009173 ATP binding site [chemical binding]; other site 522373009174 Walker B motif; other site 522373009175 arginine finger; other site 522373009176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373009177 Walker A motif; other site 522373009178 ATP binding site [chemical binding]; other site 522373009179 Walker B motif; other site 522373009180 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 522373009181 HMMPfam hit to PF02861, Clp amino terminal domain, score 2.7e-18 522373009182 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.1e-08 522373009183 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.7e-87 522373009184 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.4e-06 522373009185 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 522373009186 rRNA binding site [nucleotide binding]; other site 522373009187 predicted 30S ribosome binding site; other site 522373009188 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.5e-12 522373009189 HMMPfam hit to PF01176, Translation initiation factor 1A / IF-1, score 8.2e-37 522373009190 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 522373009191 HMMPfam hit to PF03588, Leucyl/phenylalanyl-tRNA protein transf, score 5.6e-91 522373009192 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 522373009193 Protein of unknown function, DUF482; Region: DUF482; pfam04339 522373009194 HMMPfam hit to PF04339, Protein of unknown function, DUF482, score 2.6e-185 522373009195 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 522373009196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373009197 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373009198 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 2.8e-43 522373009199 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 1.6e-24 522373009200 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 522373009201 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 522373009202 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 522373009203 5 probable transmembrane helices predicted for Smlt2344 by TMHMM2.0 at aa 38-60, 93-115, 128-150, 154-173 and 180-202 522373009204 HMMPfam hit to PF01580, FtsK/SpoIIIE family, score 2.8e-85 522373009205 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 522373009206 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 522373009207 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 522373009208 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 522373009209 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 522373009210 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein L, score 2.4e-65 522373009211 recombination factor protein RarA; Reviewed; Region: PRK13342 522373009212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373009213 Walker A motif; other site 522373009214 ATP binding site [chemical binding]; other site 522373009215 Walker B motif; other site 522373009216 arginine finger; other site 522373009217 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 522373009218 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 3.8e-18 522373009219 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 0.00017 522373009220 Protein of unknown function (DUF805); Region: DUF805; pfam05656 522373009221 HMMPfam hit to PF05656, Protein of unknown function (DUF805), score 3.6e-33 522373009222 3 probable transmembrane helices predicted for Smlt2349 by TMHMM2.0 at aa 77-99, 109-131 and 144-166 522373009223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373009224 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373009225 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373009226 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 2e-24 522373009227 HMMPfam hit to PF01548, Transposase, score 2.6e-10 522373009228 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 522373009229 Putative esterase; Region: Esterase; pfam00756 522373009230 HMMPfam hit to PF00756, Putative esterase, score 1.7e-05 522373009231 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 522373009232 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 522373009233 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 522373009234 intersubunit interface [polypeptide binding]; other site 522373009235 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.9e-13 522373009236 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 522373009237 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 522373009238 ABC-ATPase subunit interface; other site 522373009239 dimer interface [polypeptide binding]; other site 522373009240 putative PBP binding regions; other site 522373009241 9 probable transmembrane helices predicted for Smlt2356 by TMHMM2.0 at aa 13-35, 74-96, 103-125, 130-149, 162-184, 199-221, 253-275, 290-307 and 320-339 522373009242 HMMPfam hit to PF01032, FecCD transport family, score 1.1e-103 522373009243 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 522373009244 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 522373009245 Walker A/P-loop; other site 522373009246 ATP binding site [chemical binding]; other site 522373009247 Q-loop/lid; other site 522373009248 ABC transporter signature motif; other site 522373009249 Walker B; other site 522373009250 D-loop; other site 522373009251 H-loop/switch region; other site 522373009252 HMMPfam hit to PF00005, ABC transporter score 1.5e-45 522373009253 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 522373009254 Winged helix-turn helix; Region: HTH_29; pfam13551 522373009255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 522373009256 Integrase core domain; Region: rve; pfam00665 522373009257 Integrase core domain; Region: rve_3; pfam13683 522373009258 HMMPfam hit to PF00665, Integrase core domain, score 4.9e-39 522373009259 elongation factor G; Reviewed; Region: PRK12739 522373009260 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 522373009261 G1 box; other site 522373009262 GTP/Mg2+ binding site [chemical binding]; other site 522373009263 G2 box; other site 522373009264 Switch I region; other site 522373009265 G3 box; other site 522373009266 Switch II region; other site 522373009267 G4 box; other site 522373009268 G5 box; other site 522373009269 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 522373009270 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 522373009271 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 522373009272 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3.3e-95 522373009273 HMMPfam hit to PF03144, Elongation factor Tu domain, score 6.3e-14 522373009274 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 8.9e-41 522373009275 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 1.8e-22 522373009276 SapC; Region: SapC; pfam07277 522373009277 HMMPfam hit to PF07277, SapC, score 1.5e-40 522373009278 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 522373009279 membrane-bound complex binding site; other site 522373009280 hinge residues; other site 522373009281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373009282 ATP binding site [chemical binding]; other site 522373009283 Mg2+ binding site [ion binding]; other site 522373009284 G-X-G motif; other site 522373009285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373009286 active site 522373009287 phosphorylation site [posttranslational modification] 522373009288 intermolecular recognition site; other site 522373009289 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.3e-19 522373009290 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.1e-37 522373009291 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.5e-07 522373009292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373009293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 522373009294 active site 522373009295 phosphorylation site [posttranslational modification] 522373009296 intermolecular recognition site; other site 522373009297 dimerization interface [polypeptide binding]; other site 522373009298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373009299 DNA binding residues [nucleotide binding] 522373009300 dimerization interface [polypeptide binding]; other site 522373009301 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 1.2e-11 522373009302 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.6e-07 522373009303 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 522373009304 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 522373009305 HMMPfam hit to PF08212, Lipocalin-like domain, score 3.2e-59 522373009306 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 522373009307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373009308 S-adenosylmethionine binding site [chemical binding]; other site 522373009309 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid, score 2.4e-14 522373009310 HMMPfam hit to PF08241, Methyltransferase domain, score 1.4e-21 522373009311 HMMPfam hit to PF08242, Methyltransferase domain, score 1.8e-08 522373009312 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 522373009313 HMMPfam hit to PF06966, Protein of unknown function (DUF1295), score 4.4e-81 522373009314 5 probable transmembrane helices predicted for Smlt2369 by TMHMM2.0 at aa 4-21, 33-55, 102-124, 131-148 and 187-209 522373009315 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 522373009316 4 probable transmembrane helices predicted for Smlt2370 by TMHMM2.0 at aa 52-74, 89-108, 113-132 and 142-161 522373009317 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 522373009318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373009319 S-adenosylmethionine binding site [chemical binding]; other site 522373009320 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid, score 1.2e-98 522373009321 HMMPfam hit to PF08241, Methyltransferase domain, score 2.7e-12 522373009322 HMMPfam hit to PF08242, Methyltransferase domain, score 1.6e-09 522373009323 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 522373009324 HMMPfam hit to PF07103, Protein of unknown function (DUF1365), score 1e-123 522373009325 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 522373009326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 522373009327 HMMPfam hit to PF01593, Flavin containing amine oxidoreductase, score 0.0013 522373009328 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 522373009329 Di-iron ligands [ion binding]; other site 522373009330 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 522373009331 HMMPfam hit to PF00487, Fatty acid desaturase, score 2.9e-37 522373009332 4 probable transmembrane helices predicted for Smlt2374 by TMHMM2.0 at aa 40-62, 66-88, 179-198 and 213-235 522373009333 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 522373009334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373009335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373009336 DNA binding residues [nucleotide binding] 522373009337 HMMPfam hit to PF04542, Sigma-70 region, score 1.3e-14 522373009338 HMMPfam hit to PF08281, Sigma-70, region, score 3.2e-16 522373009339 HMMPfam hit to PF04545, Sigma-70, region, score 7.8e-13 522373009340 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 522373009341 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 522373009342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373009343 NAD(P) binding site [chemical binding]; other site 522373009344 active site 522373009345 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373009346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373009347 active site 522373009348 phosphorylation site [posttranslational modification] 522373009349 intermolecular recognition site; other site 522373009350 dimerization interface [polypeptide binding]; other site 522373009351 PAS fold; Region: PAS_4; pfam08448 522373009352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373009353 putative active site [active] 522373009354 heme pocket [chemical binding]; other site 522373009355 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 522373009356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373009357 dimer interface [polypeptide binding]; other site 522373009358 phosphorylation site [posttranslational modification] 522373009359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373009360 ATP binding site [chemical binding]; other site 522373009361 Mg2+ binding site [ion binding]; other site 522373009362 G-X-G motif; other site 522373009363 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373009364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373009365 active site 522373009366 phosphorylation site [posttranslational modification] 522373009367 intermolecular recognition site; other site 522373009368 dimerization interface [polypeptide binding]; other site 522373009369 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.8e-17 522373009370 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.3e-28 522373009371 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1e-06 522373009372 HMMPfam hit to PF08448, PAS fold, score 1.2e-08 522373009373 HMMPfam hit to PF08448, PAS fold, score 4.6e-21 522373009374 HMMPfam hit to PF08447, PAS fold, score 0.0012 522373009375 HMMPfam hit to PF00989, PAS fold, score 0.0037 522373009376 HMMPfam hit to PF00072, Response regulator receiver domain, score 7.8e-12 522373009377 Response regulator receiver domain; Region: Response_reg; pfam00072 522373009378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373009379 active site 522373009380 phosphorylation site [posttranslational modification] 522373009381 intermolecular recognition site; other site 522373009382 dimerization interface [polypeptide binding]; other site 522373009383 HMMPfam hit to PF00072, Response regulator receiver domain, score 8.4e-18 522373009384 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 522373009385 GAF domain; Region: GAF; pfam01590 522373009386 Phytochrome region; Region: PHY; pfam00360 522373009387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373009388 dimer interface [polypeptide binding]; other site 522373009389 phosphorylation site [posttranslational modification] 522373009390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373009391 ATP binding site [chemical binding]; other site 522373009392 Mg2+ binding site [ion binding]; other site 522373009393 G-X-G motif; other site 522373009394 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP, score 1.6e-31 522373009395 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 5.9e-11 522373009396 HMMPfam hit to PF00360, Phytochrome region, score 2.2e-21 522373009397 HMMPfam hit to PF01590, GAF domain, score 8.9e-21 522373009398 HMMPfam hit to PF08446, PAS fold, score 7.6e-06 522373009399 TspO/MBR family; Region: TspO_MBR; pfam03073 522373009400 HMMPfam hit to PF03073, TspO/MBR family, score 2.4e-39 522373009401 5 probable transmembrane helices predicted for Smlt2384 by TMHMM2.0 at aa 13-35, 55-77, 84-106, 111-133 and 140-162 522373009402 1 probable transmembrane helix predicted for Smlt2385 by TMHMM2.0 at aa 20-42 522373009403 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 522373009404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373009405 Coenzyme A binding pocket [chemical binding]; other site 522373009406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 522373009407 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.9e-14 522373009408 3 probable transmembrane helices predicted for Smlt2387 by TMHMM2.0 at aa 5-27, 48-70 and 80-102 522373009409 1 probable transmembrane helix predicted for Smlt2388 by TMHMM2.0 at aa 15-32 522373009410 hypothetical protein; Region: PHA01083 522373009411 Phage related protein; Region: DUF3693; pfam12472 522373009412 2 probable transmembrane helices predicted for Smlt2390 by TMHMM2.0 at aa 10-32 and 52-71 522373009413 2 probable transmembrane helices predicted for Smlt2391 by TMHMM2.0 at aa 7-29 and 33-52 522373009414 putative replication initiation protein; Region: PHA00330 522373009415 Helix-destabilising protein; Region: Phage_DNA_bind; pfam02303 522373009416 HMMPfam hit to PF02303, Helix-destabilising protein, score 3.3e-07 522373009417 1 probable transmembrane helix predicted for Smlt2394 by TMHMM2.0 at aa 45-64 522373009418 2 probable transmembrane helices predicted for Smlt2395 by TMHMM2.0 at aa 20-42 and 62-84 522373009419 1 probable transmembrane helix predicted for Smlt2396 by TMHMM2.0 at aa 23-45 522373009420 2 probable transmembrane helices predicted for Smlt2397 by TMHMM2.0 at aa 7-29 and 436-458 522373009421 2 probable transmembrane helices predicted for Smlt2398 by TMHMM2.0 at aa 12-34 and 69-86 522373009422 Zonular occludens toxin (Zot); Region: Zot; cl17485 522373009423 HMMPfam hit to PF05707, Zonular occludens toxin (Zot), score 5.5e-42 522373009424 1 probable transmembrane helix predicted for Smlt2399 by TMHMM2.0 at aa 183-205 522373009425 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 522373009426 2 probable transmembrane helices predicted for Smlt2404 by TMHMM2.0 at aa 81-103 and 124-142 522373009427 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 522373009428 Isochorismatase family; Region: Isochorismatase; pfam00857 522373009429 catalytic triad [active] 522373009430 conserved cis-peptide bond; other site 522373009431 HMMPfam hit to PF00857, Isochorismatase family, score 0.00022 522373009432 3 probable transmembrane helices predicted for Smlt2406 by TMHMM2.0 at aa 24-46, 56-78 and 99-121 522373009433 conserved hypothetical protein, pseudogene;Similar to N-terminus to codon 150 of Xanthomonas campestris pv. vesicatoria (strain 85-10). hypothetical protein. UniProt:Q3C046 (EMBL:AM039951 (347 aa) fasta scores: E()=1.3e-06, 33.803% id in 142 aa; similarity:fasta; with=UniProt:Q3C046 (EMBL:AM039951;); Xanthomonas campestris pv. vesicatoria (strain 85-10).; Hypothetical protein.; length=347; id 33.803%; ungapped id 36.364%; E()=1.3e-06; 142 aa overlap; query 5-136; subject 7-148 522373009434 putative transposase OrfB; Reviewed; Region: PHA02517 522373009435 HTH-like domain; Region: HTH_21; pfam13276 522373009436 Integrase core domain; Region: rve; pfam00665 522373009437 Integrase core domain; Region: rve_2; pfam13333 522373009438 HMMPfam hit to PF00665, Integrase core domain, score 6.6e-51 522373009439 putative transcriptional regulator MerR; Provisional; Region: PRK13752 522373009440 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 522373009441 DNA binding residues [nucleotide binding] 522373009442 dimer interface [polypeptide binding]; other site 522373009443 mercury binding site [ion binding]; other site 522373009444 HMMPfam hit to PF00376, MerR family regulatory protein, score 2.2e-11 522373009445 putative mercuric transport protein; Provisional; Region: PRK13751 522373009446 HMMPfam hit to PF02411, MerT mercuric transport protein, score 7.6e-76 522373009447 3 probable transmembrane helices predicted for Smlt2410 by TMHMM2.0 at aa 42-64, 79-98 and 125-147 522373009448 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 522373009449 metal-binding site [ion binding] 522373009450 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1e-09 522373009451 putative mercuric reductase; Provisional; Region: PRK13748 522373009452 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 522373009453 metal-binding site [ion binding] 522373009454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373009455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373009456 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 522373009457 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1.9e-14 522373009458 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00017 522373009459 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 9.4e-69 522373009460 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 3.1e-23 522373009461 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 2.3e-44 522373009462 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 522373009463 Transposase; Region: DDE_Tnp_ISL3; pfam01610 522373009464 HMMPfam hit to PF01610, Transposase, score 1.1e-33 522373009465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373009466 Transposase; Region: HTH_Tnp_1; pfam01527 522373009467 HMMPfam hit to PF01527, Transposase, score 1.6e-22 522373009468 Transposase; Region: HTH_Tnp_1; pfam01527 522373009469 HMMPfam hit to PF01527, Transposase, score 7.8e-25 522373009470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 522373009471 HTH-like domain; Region: HTH_21; pfam13276 522373009472 Integrase core domain; Region: rve; pfam00665 522373009473 Integrase core domain; Region: rve_3; pfam13683 522373009474 HMMPfam hit to PF00665, Integrase core domain, score 2.7e-39 522373009475 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 522373009476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 522373009477 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 0.00031 522373009478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373009479 dimerization interface [polypeptide binding]; other site 522373009480 putative DNA binding site [nucleotide binding]; other site 522373009481 putative Zn2+ binding site [ion binding]; other site 522373009482 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 0.004 522373009483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373009484 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373009485 11 probable transmembrane helices predicted for Smlt2420 by TMHMM2.0 at aa 15-37, 44-66, 81-100, 107-129, 139-161, 168-190, 224-246, 248-270, 290-312, 319-341 and 377-399 522373009486 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6e-15 522373009487 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 522373009488 ArsC family; Region: ArsC; pfam03960 522373009489 catalytic residues [active] 522373009490 HMMPfam hit to PF03960, ArsC family, score 5.1e-44 522373009491 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 522373009492 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373009493 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 4.2e-53 522373009494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373009495 putative DNA binding site [nucleotide binding]; other site 522373009496 putative Zn2+ binding site [ion binding]; other site 522373009497 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 0.00046 522373009498 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 522373009499 Low molecular weight phosphatase family; Region: LMWPc; cl00105 522373009500 active site 522373009501 HMMPfam hit to PF01451, Low molecular weight phosphotyrosine protein, score 5.1e-24 522373009502 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 522373009503 arsenical-resistance protein; Region: acr3; TIGR00832 522373009504 10 probable transmembrane helices predicted for Smlt2425 by TMHMM2.0 at aa 13-35, 39-61, 82-104, 108-130, 143-165, 185-207, 220-242, 257-276, 289-311 and 316-338 522373009505 HMMPfam hit to PF01758, Sodium Bile acid symporter family, score 8.1e-73 522373009506 thioredoxin reductase; Provisional; Region: PRK10262 522373009507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373009508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373009509 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 2.1e-41 522373009510 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 3.7e-23 522373009511 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 522373009512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 522373009513 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 0.0023 522373009514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373009515 dimerization interface [polypeptide binding]; other site 522373009516 putative DNA binding site [nucleotide binding]; other site 522373009517 putative Zn2+ binding site [ion binding]; other site 522373009518 1 probable transmembrane helix predicted for Smlt2429 by TMHMM2.0 at aa 10-32 522373009519 1 probable transmembrane helix predicted for Smlt2431 by TMHMM2.0 at aa 17-39 522373009520 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 522373009521 Outer membrane efflux protein; Region: OEP; pfam02321 522373009522 1 probable transmembrane helix predicted for Smlt2432 by TMHMM2.0 at aa 34-56 522373009523 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.00051 522373009524 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.0038 522373009525 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 522373009526 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373009527 1 probable transmembrane helix predicted for Smlt2433 by TMHMM2.0 at aa 7-29 522373009528 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 522373009529 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 1.6e-198 522373009530 12 probable transmembrane helices predicted for Smlt2434 by TMHMM2.0 at aa 24-46, 356-373, 378-400, 404-426, 459-481, 496-518, 543-565, 887-904, 911-929, 939-961, 998-1017 and 1027-1049 522373009531 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 522373009532 putative formimidoylglutamase, pseudogene 522373009533 Domain of unknown function (DUF305); Region: DUF305; cl17794 522373009534 HMMPfam hit to PF03713, Domain of unknown function (DUF305), score 1.9e-17 522373009535 3 probable transmembrane helices predicted for Smlt2438 by TMHMM2.0 at aa 39-61, 74-93 and 103-120 522373009536 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 522373009537 EF-hand domain pair; Region: EF_hand_5; pfam13499 522373009538 Ca2+ binding site [ion binding]; other site 522373009539 1 probable transmembrane helix predicted for Smlt2439 by TMHMM2.0 at aa 24-46 522373009540 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 522373009541 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 522373009542 Soluble P-type ATPase [General function prediction only]; Region: COG4087 522373009543 7 probable transmembrane helices predicted for Smlt2440 by TMHMM2.0 at aa 137-156, 166-185, 198-220, 235-254, 389-411, 416-438 and 737-759 522373009544 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 8e-36 522373009545 HMMPfam hit to PF00122, E1-E2 ATPase, score 4e-91 522373009546 HMMPfam hit to PF05425, Copper resistance protein D, score 5.5e-58 522373009547 8 probable transmembrane helices predicted for Smlt2441 by TMHMM2.0 at aa 6-28, 40-62, 96-115, 128-150, 160-182, 202-224, 244-266 and 289-311 522373009548 CopC domain; Region: CopC; pfam04234 522373009549 HMMPfam hit to PF04234, Copper resistance protein CopC, score 3.8e-22 522373009550 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 522373009551 dimerization interface [polypeptide binding]; other site 522373009552 HMMPfam hit to PF03860, no description, score 0.06 522373009553 HMMPfam hit to PF03860, no description, score 0.31 522373009554 HMMPfam hit to PF03860, no description, score 5.9 522373009555 Predicted metal-binding protein [General function prediction only]; Region: COG3019 522373009556 HMMPfam hit to PF04214, Protein of unknown function, DUF, score 1.7e-43 522373009557 SnoaL-like domain; Region: SnoaL_3; pfam13474 522373009558 SnoaL-like domain; Region: SnoaL_2; pfam12680 522373009559 1 probable transmembrane helix predicted for Smlt2445 by TMHMM2.0 at aa 10-32 522373009560 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 522373009561 1 probable transmembrane helix predicted for Smlt2446 by TMHMM2.0 at aa 7-29 522373009562 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 522373009563 HMMPfam hit to PF05275, Copper resistance protein B precursor (CopB), score 5.3e-154 522373009564 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 522373009565 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 522373009566 Multicopper oxidase; Region: Cu-oxidase; pfam00394 522373009567 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 522373009568 HMMPfam hit to PF07731, Multicopper oxidase, score 9e-38 522373009569 HMMPfam hit to PF00394, Multicopper oxidase, score 9.6e-35 522373009570 HMMPfam hit to PF07732, Multicopper oxidase, score 1.4e-51 522373009571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373009572 non-specific DNA binding site [nucleotide binding]; other site 522373009573 salt bridge; other site 522373009574 sequence-specific DNA binding site [nucleotide binding]; other site 522373009575 HipA-like C-terminal domain; Region: HipA_C; pfam07804 522373009576 HMMPfam hit to PF01381, Helix-turn-helix, score 2.3e-09 522373009577 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 522373009578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373009579 AAA domain; Region: AAA_21; pfam13304 522373009580 Walker A/P-loop; other site 522373009581 ATP binding site [chemical binding]; other site 522373009582 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 522373009583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373009584 ABC transporter signature motif; other site 522373009585 Walker B; other site 522373009586 D-loop; other site 522373009587 H-loop/switch region; other site 522373009588 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 522373009589 putative active site [active] 522373009590 putative metal-binding site [ion binding]; other site 522373009591 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 522373009592 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 522373009593 putative cation efflux transporter pseudogene;similarity:fasta; with=UniProt:Q9ALR5; Pseudomonas fluorescens.; cztD; CztD (Fragment).; length=85; id 29.730%; ungapped id 30.137%; E()=1.6; 74 aa overlap; query 5-77; subject 1-74 522373009594 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 522373009595 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373009596 11 probable transmembrane helices predicted for Smlt2457 by TMHMM2.0 at aa 344-366, 373-395, 399-418, 452-474, 489-511, 542-564, 896-915, 922-944, 948-970, 991-1013 and 1028-1050 522373009597 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 522373009598 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373009599 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 522373009600 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 0.00017 522373009601 Outer membrane efflux protein; Region: OEP; pfam02321 522373009602 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.0029 522373009603 HMMPfam hit to PF02321, Outer membrane efflux protein, score 7.3e-08 522373009604 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 522373009605 HMMPfam hit to PF01545, Cation efflux family, score 1.7e-05 522373009606 6 probable transmembrane helices predicted for Smlt2461 by TMHMM2.0 at aa 19-41, 45-67, 74-96, 106-128, 149-167 and 172-191 522373009607 Cytochrome c; Region: Cytochrom_C; pfam00034 522373009608 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50; Region: FTA4; pfam13093 522373009609 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 522373009610 HMMPfam hit to PF03239, Iron permease FTR1 family, score 1.2e-07 522373009611 7 probable transmembrane helices predicted for Smlt2462 by TMHMM2.0 at aa 401-420, 432-454, 464-483, 503-525, 540-562, 574-596 and 624-646 522373009612 HMMPfam hit to PF00034, Cytochrome c, score 0.012 522373009613 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 522373009614 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 522373009615 DNA binding residues [nucleotide binding] 522373009616 dimer interface [polypeptide binding]; other site 522373009617 putative metal binding site [ion binding]; other site 522373009618 HMMPfam hit to PF00376, MerR family regulatory protein, score 2.4e-13 522373009619 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 522373009620 DNA binding site [nucleotide binding] 522373009621 dimer interface [polypeptide binding]; other site 522373009622 active site 522373009623 Int/Topo IB signature motif; other site 522373009624 HMMPfam hit to PF00589, Phage integrase family, score 2.1e-06 522373009625 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 522373009626 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 522373009627 HMMPfam hit to PF01526, Transposase, score 1.3e-66 522373009628 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 522373009629 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 522373009630 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 522373009631 active site 522373009632 DNA binding site [nucleotide binding] 522373009633 Int/Topo IB signature motif; other site 522373009634 HMMPfam hit to PF00589, Phage integrase family, score 1.9e-06 522373009635 Predicted transcriptional regulator [Transcription]; Region: COG2378 522373009636 WYL domain; Region: WYL; pfam13280 522373009637 putative phage related protein, pseudogene;Similar to N-terminus of Mycobacterium phage plot. 41 UniProt:Q19YA8 (EMBL:DQ398051 (193 aa) fasta scores: E()=5.8e-05, 57.500% id in 40 aa, and to C-terminus of Haloarcula marismortui (halobacterium marismortui). hypothetical protein. UniProt:Q5UYT0 (EMBL:AY596297 (535 aa) fasta scores: E()=1.7e-06, 55.556% id in 54 aa; similarity:fasta; with=UniProt:Q19YA8 (EMBL:DQ398051;); Mycobacterium phage PLot.; 41; Gp41.; length=193; id 57.500%; ungapped id 57.500%; E()=5.8e-05; 40 aa overlap; query 4-43; subject 3-42; similarity:fasta; with=UniProt:Q5UYT0 (EMBL:AY596297;); Haloarcula marismortui (Halobacterium marismortui).; Hypothetical protein.; length=535; id 55.556%; ungapped id 55.556%; E()=1.7e-06; 54 aa overlap; query 6-59; subject 369-422 522373009638 HMMPfam hit to PF07411, Domain of unknown function (DUF1508), score 2.9e-06 522373009639 2 probable transmembrane helices predicted for Smlt2477 by TMHMM2.0 at aa 42-64 and 74-92 522373009640 putative transposase OrfB; Reviewed; Region: PHA02517 522373009641 HTH-like domain; Region: HTH_21; pfam13276 522373009642 Integrase core domain; Region: rve; pfam00665 522373009643 Integrase core domain; Region: rve_2; pfam13333 522373009644 HMMPfam hit to PF00665, Integrase core domain, score 3.3e-32 522373009645 Transposase; Region: HTH_Tnp_1; pfam01527 522373009646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373009647 HMMPfam hit to PF01527, Transposase, score 1.1e-20 522373009648 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 522373009649 AAA ATPase domain; Region: AAA_16; pfam13191 522373009650 AAA domain; Region: AAA_22; pfam13401 522373009651 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 522373009652 Phage protein; Region: DUF3653; pfam12375 522373009653 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 522373009654 active site 522373009655 DNA binding site [nucleotide binding] 522373009656 Int/Topo IB signature motif; other site 522373009657 HMMPfam hit to PF00589, Phage integrase family, score 2.4e-05 522373009658 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 522373009659 RNase_H superfamily; Region: RNase_H_2; pfam13482 522373009660 Part of AAA domain; Region: AAA_19; pfam13245 522373009661 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 522373009662 AAA domain; Region: AAA_12; pfam13087 522373009663 putative transposase OrfB; Reviewed; Region: PHA02517 522373009664 HTH-like domain; Region: HTH_21; pfam13276 522373009665 Integrase core domain; Region: rve; pfam00665 522373009666 Integrase core domain; Region: rve_2; pfam13333 522373009667 HMMPfam hit to PF00665, Integrase core domain, score 9e-51 522373009668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373009669 Transposase; Region: HTH_Tnp_1; pfam01527 522373009670 HMMPfam hit to PF01527, Transposase, score 1.1e-21 522373009671 AAA domain; Region: AAA_21; pfam13304 522373009672 Thymidylate synthase complementing protein; Region: Thy1; cl03630 522373009673 1 probable transmembrane helix predicted for Smlt2495 by TMHMM2.0 at aa 4-26 522373009674 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 522373009675 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 522373009676 2 probable transmembrane helices predicted for Smlt2497 by TMHMM2.0 at aa 4-21 and 28-50 522373009677 4 probable transmembrane helices predicted for Smlt2498 by TMHMM2.0 at aa 21-40, 60-77, 97-119 and 139-161 522373009678 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 522373009679 Ligand binding site; other site 522373009680 metal-binding site 522373009681 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 522373009682 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 522373009683 XdhC Rossmann domain; Region: XdhC_C; pfam13478 522373009684 HMMPfam hit to PF02625, XdhC and CoxI family, score 4.5e-13 522373009685 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 522373009686 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 522373009687 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 522373009688 HMMPfam hit to PF02738, Aldehyde oxidase and xanthine dehydroge, score 4.1e-119 522373009689 HMMPfam hit to PF01315, Aldehyde oxidase and xanthine dehydroge, score 8.6e-20 522373009690 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 522373009691 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 522373009692 HMMPfam hit to PF00941, FAD binding domain in molybdopterin deh, score 3.5e-89 522373009693 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 522373009694 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 522373009695 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 522373009696 HMMPfam hit to PF01799, [2Fe-2S] binding domain, score 3.6e-36 522373009697 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 1.6e-13 522373009698 4 probable transmembrane helices predicted for Smlt2506 by TMHMM2.0 at aa 46-65, 75-97, 157-179 and 194-216 522373009699 OsmC-like protein; Region: OsmC; cl00767 522373009700 HMMPfam hit to PF02566, OsmC-like protein, score 2.2e-29 522373009701 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 522373009702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373009703 NAD(P) binding site [chemical binding]; other site 522373009704 active site 522373009705 HMMPfam hit to PF04321, RmlD substrate binding domain, score 8.4e-05 522373009706 HMMPfam hit to PF05368, NmrA-like family, score 2.7e-07 522373009707 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 5.3e-05 522373009708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373009709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373009710 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373009711 putative effector binding pocket; other site 522373009712 dimerization interface [polypeptide binding]; other site 522373009713 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.6e-47 522373009714 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.1e-18 522373009715 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373009716 DNA binding residues [nucleotide binding] 522373009717 HMMPfam hit to PF08281, Sigma-70, region, score 1.1e-11 522373009718 Uncharacterized conserved protein [Function unknown]; Region: COG2128 522373009719 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 522373009720 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 7.5e-16 522373009721 Cupin domain; Region: Cupin_2; pfam07883 522373009722 HMMPfam hit to PF07883, Cupin domain, score 3.5e-15 522373009723 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 522373009724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373009725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373009726 DNA binding residues [nucleotide binding] 522373009727 HMMPfam hit to PF04542, Sigma-70 region, score 5e-17 522373009728 HMMPfam hit to PF08281, Sigma-70, region, score 2.3e-12 522373009729 HMMPfam hit to PF04545, Sigma-70, region, score 9.2e-06 522373009730 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 522373009731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 522373009732 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1e-20 522373009733 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 522373009734 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 522373009735 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373009736 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.3e-41 522373009737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373009738 Walker A/P-loop; other site 522373009739 ATP binding site [chemical binding]; other site 522373009740 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 522373009741 Q-loop/lid; other site 522373009742 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 522373009743 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 522373009744 HMMPfam hit to PF00005, ABC transporter score 6.1e-21 522373009745 HMMPfam hit to PF00005, ABC transporter score 8.2e-08 522373009746 1 probable transmembrane helix predicted for Smlt2524 by TMHMM2.0 at aa 96-118 522373009747 Low affinity iron permease; Region: Iron_permease; pfam04120 522373009748 HMMPfam hit to PF07300, Protein of unknown function (DUF1452), score 1.8e-47 522373009749 2 probable transmembrane helices predicted for Smlt2526 by TMHMM2.0 at aa 13-35 and 45-64 522373009750 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 522373009751 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 522373009752 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 522373009753 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 522373009754 [2Fe-2S] cluster binding site [ion binding]; other site 522373009755 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain, score 1.3e-17 522373009756 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 5.9e-29 522373009757 Sensors of blue-light using FAD; Region: BLUF; pfam04940 522373009758 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 522373009759 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 522373009760 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 522373009761 active site 522373009762 DNA binding site [nucleotide binding] 522373009763 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 522373009764 DNA binding site [nucleotide binding] 522373009765 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 522373009766 nucleotide binding site [chemical binding]; other site 522373009767 HMMPfam hit to PF04679, ATP dependent DNA ligase C terminal re, score 0.0016 522373009768 HMMPfam hit to PF01068, ATP dependent DNA ligase domain, score 3.8e-25 522373009769 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 522373009770 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 522373009771 dimerization interface [polypeptide binding]; other site 522373009772 metal binding site [ion binding]; metal-binding site 522373009773 HMMPfam hit to PF05974, Protein of unknown function (DUF892), score 1.9e-92 522373009774 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 522373009775 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_2; cd08974 522373009776 putative DNA binding site [nucleotide binding]; other site 522373009777 catalytic residue [active] 522373009778 putative H2TH interface [polypeptide binding]; other site 522373009779 putative catalytic residues [active] 522373009780 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 522373009781 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycosylase H2, score 1.5e-08 522373009782 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase N-, score 9.6e-06 522373009783 Protein of unknown function DUF72; Region: DUF72; pfam01904 522373009784 HMMPfam hit to PF01904, Protein of unknown function DUF72, score 6.1e-80 522373009785 Sensors of blue-light using FAD; Region: BLUF; pfam04940 522373009786 HMMPfam hit to PF04940, Sensors of blue-light using FAD, score 7.7e-10 522373009787 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 522373009788 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 522373009789 dimanganese center [ion binding]; other site 522373009790 HMMPfam hit to PF05067, Manganese containing catalase, score 6e-111 522373009791 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 522373009792 dinuclear metal binding motif [ion binding]; other site 522373009793 HMMPfam hit to PF05974, Protein of unknown function (DUF892), score 6.3e-39 522373009794 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373009795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373009796 active site 522373009797 phosphorylation site [posttranslational modification] 522373009798 intermolecular recognition site; other site 522373009799 dimerization interface [polypeptide binding]; other site 522373009800 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.8e-05 522373009801 Sensors of blue-light using FAD; Region: BLUF; pfam04940 522373009802 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 522373009803 active site 522373009804 HMMPfam hit to PF00535, Glycosyl transferase family, score 2.9e-07 522373009805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373009806 S-adenosylmethionine binding site [chemical binding]; other site 522373009807 HMMPfam hit to PF05401, Nodulation protein S (NodS), score 2.1e-08 522373009808 HMMPfam hit to PF08241, Methyltransferase domain, score 1.6e-06 522373009809 HMMPfam hit to PF08242, Methyltransferase domain, score 1e-11 522373009810 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 522373009811 HMMPfam hit to PF02585, GlcNAc-PI de-N-acetylase, score 2e-39 522373009812 4 probable transmembrane helices predicted for Smlt2547 by TMHMM2.0 at aa 2-24, 39-57, 62-84 and 134-153 522373009813 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 522373009814 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 522373009815 NAD binding site [chemical binding]; other site 522373009816 catalytic Zn binding site [ion binding]; other site 522373009817 structural Zn binding site [ion binding]; other site 522373009818 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 2.3e-19 522373009819 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 9.3e-41 522373009820 Isochorismatase family; Region: Isochorismatase; pfam00857 522373009821 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 522373009822 catalytic triad [active] 522373009823 conserved cis-peptide bond; other site 522373009824 HMMPfam hit to PF00857, Isochorismatase family, score 2.1e-10 522373009825 Transcriptional regulators [Transcription]; Region: PurR; COG1609 522373009826 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 522373009827 DNA binding site [nucleotide binding] 522373009828 domain linker motif; other site 522373009829 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 522373009830 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 9.1e-20 522373009831 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.9e-08 522373009832 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 522373009833 active site 522373009834 phosphorylation site [posttranslational modification] 522373009835 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 522373009836 dimerization domain swap beta strand [polypeptide binding]; other site 522373009837 regulatory protein interface [polypeptide binding]; other site 522373009838 active site 522373009839 regulatory phosphorylation site [posttranslational modification]; other site 522373009840 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 522373009841 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 522373009842 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 522373009843 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 522373009844 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar p, score 3.9e-63 522373009845 HMMPfam hit to PF00381, PTS HPr component phosphorylation sit, score 1.7e-16 522373009846 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 1e-22 522373009847 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 3.8e-25 522373009848 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 8.2e-159 522373009849 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 522373009850 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 522373009851 putative substrate binding site [chemical binding]; other site 522373009852 putative ATP binding site [chemical binding]; other site 522373009853 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 6.7e-50 522373009854 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 522373009855 active site 522373009856 P-loop; other site 522373009857 phosphorylation site [posttranslational modification] 522373009858 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 522373009859 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 9.1e-61 522373009860 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 5e-16 522373009861 8 probable transmembrane helices predicted for Smlt2558 by TMHMM2.0 at aa 243-265, 280-302, 315-337, 357-387, 399-418, 438-460, 497-519 and 534-556 522373009862 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 522373009863 HMMPfam hit to PF04966, Carbohydrate-selective porin, OprB family, score 6.1e-111 522373009864 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 522373009865 NmrA-like family; Region: NmrA; pfam05368 522373009866 NAD(P) binding site [chemical binding]; other site 522373009867 active site lysine 522373009868 HMMPfam hit to PF05368, NmrA-like family, score 1.2e-07 522373009869 Predicted transcriptional regulators [Transcription]; Region: COG1733 522373009870 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 522373009871 HMMPfam hit to PF01638, HxlR-like helix-turn-helix, score 2.4e-24 522373009872 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 522373009873 Fasciclin domain; Region: Fasciclin; pfam02469 522373009874 HMMPfam hit to PF02469, Fasciclin domain, score 1.9e-54 522373009875 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373009876 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373009877 HMMPfam hit to PF00144, Beta-lactamase, score 1.3e-35 522373009878 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373009879 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373009880 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373009881 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.6e-10 522373009882 HMMPfam hit to PF00593, TonB dependent receptor, score 1.8e-17 522373009883 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 522373009884 L-fucose transporter; Provisional; Region: PRK10133; cl17665 522373009885 L-fucose transporter; Provisional; Region: PRK10133; cl17665 522373009886 14 probable transmembrane helices predicted for Smlt2567 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 105-127, 148-170, 185-204, 234-256, 276-298, 311-333, 338-355, 362-384, 389-411, 418-440 and 444-466 522373009887 Transcriptional regulators [Transcription]; Region: PurR; COG1609 522373009888 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 522373009889 DNA binding site [nucleotide binding] 522373009890 domain linker motif; other site 522373009891 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 522373009892 putative dimerization interface [polypeptide binding]; other site 522373009893 putative ligand binding site [chemical binding]; other site 522373009894 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 4.7e-08 522373009895 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 6.1e-10 522373009896 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 522373009897 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 522373009898 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 522373009899 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N termina, score 4.3e-69 522373009900 HMMPfam hit to PF01915, Glycosyl hydrolase family 3 C termina, score 2.9e-49 522373009901 12 probable transmembrane helices predicted for Smlt2570 by TMHMM2.0 at aa 20-42, 62-84, 91-113, 163-185, 198-220, 235-257, 284-302, 306-323, 336-358, 384-406, 419-441 and 456-474 522373009902 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 522373009903 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 522373009904 transmembrane helices; other site 522373009905 HMMPfam hit to PF03600, Citrate transporter score 7.2e-07 522373009906 HMMPfam hit to PF02040, Arsenical pump membrane protein, score 1.2e-09 522373009907 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 522373009908 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 522373009909 HMMPfam hit to PF07396, Phosphate-selective porin O and P, score 1.2e-11 522373009910 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 522373009911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373009912 dimer interface [polypeptide binding]; other site 522373009913 conserved gate region; other site 522373009914 putative PBP binding loops; other site 522373009915 ABC-ATPase subunit interface; other site 522373009916 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 9.3e-25 522373009917 5 probable transmembrane helices predicted for Smlt2572 by TMHMM2.0 at aa 30-52, 88-107, 128-150, 208-230 and 237-259 522373009918 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 522373009919 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 522373009920 Walker A/P-loop; other site 522373009921 ATP binding site [chemical binding]; other site 522373009922 Q-loop/lid; other site 522373009923 ABC transporter signature motif; other site 522373009924 Walker B; other site 522373009925 D-loop; other site 522373009926 H-loop/switch region; other site 522373009927 HMMPfam hit to PF00005, ABC transporter score 5.5e-64 522373009928 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 522373009929 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 522373009930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 522373009931 HMMPfam hit to PF04303, Protein of unknown function (DUF453), score 1e-185 522373009932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373009933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373009934 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 522373009935 putative dimerization interface [polypeptide binding]; other site 522373009936 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.2e-20 522373009937 HMMPfam hit to PF03466, LysR substrate binding domain, score 7.8e-60 522373009938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373009939 Walker A/P-loop; other site 522373009940 ATP binding site [chemical binding]; other site 522373009941 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 522373009942 Q-loop/lid; other site 522373009943 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 522373009944 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 522373009945 HMMPfam hit to PF00005, ABC transporter score 1.2e-17 522373009946 Sensors of blue-light using FAD; Region: BLUF; pfam04940 522373009947 HMMPfam hit to PF04940, Sensors of blue-light using FAD, score 1.6e-14 522373009948 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 522373009949 FAD binding site [chemical binding]; other site 522373009950 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 3.1e-05 522373009951 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 522373009952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373009953 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 522373009954 putative dimerization interface [polypeptide binding]; other site 522373009955 HMMPfam hit to PF03466, LysR substrate binding domain, score 2e-34 522373009956 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.1e-14 522373009957 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373009958 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 522373009959 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 2.9e-06 522373009960 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 522373009961 methionine synthase; Provisional; Region: PRK01207 522373009962 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 522373009963 substrate binding site [chemical binding]; other site 522373009964 THF binding site; other site 522373009965 zinc-binding site [ion binding]; other site 522373009966 HMMPfam hit to PF01717, Cobalamin-independent synthase, Catalytic, score 6.8e-19 522373009967 1 probable transmembrane helix predicted for Smlt2587 by TMHMM2.0 at aa 7-29 522373009968 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 522373009969 active site 522373009970 substrate binding sites [chemical binding]; other site 522373009971 HMMPfam hit to PF00089, Trypsin, score 6.2e-06 522373009972 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373009973 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373009974 HMMPfam hit to PF00144, Beta-lactamase, score 9.1e-43 522373009975 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 522373009976 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373009977 1 probable transmembrane helix predicted for Smlt2590 by TMHMM2.0 at aa 12-34 522373009978 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373009979 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373009980 N-terminal plug; other site 522373009981 ligand-binding site [chemical binding]; other site 522373009982 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.1e-20 522373009983 HMMPfam hit to PF00593, TonB dependent receptor, score 1.5e-31 522373009984 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 522373009985 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373009986 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 2.2e-12 522373009987 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 522373009988 active site 2 [active] 522373009989 active site 1 [active] 522373009990 HMMPfam hit to PF01575, MaoC like domain, score 1.6e-13 522373009991 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 522373009992 PAS domain; Region: PAS; smart00091 522373009993 PAS fold; Region: PAS_7; pfam12860 522373009994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373009995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373009996 ATP binding site [chemical binding]; other site 522373009997 Mg2+ binding site [ion binding]; other site 522373009998 G-X-G motif; other site 522373009999 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373010000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373010001 active site 522373010002 phosphorylation site [posttranslational modification] 522373010003 intermolecular recognition site; other site 522373010004 dimerization interface [polypeptide binding]; other site 522373010005 12 probable transmembrane helices predicted for Smlt2594 by TMHMM2.0 at aa 5-24, 36-55, 70-92, 113-132, 152-174, 187-209, 237-259, 272-294, 317-339, 372-389, 404-422 and 429-451 522373010006 HMMPfam hit to PF08448, PAS fold, score 0.0012 522373010007 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.2e-08 522373010008 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 6.2e-29 522373010009 HMMPfam hit to PF00072, Response regulator receiver domain, score 0.00033 522373010010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373010011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373010012 active site 522373010013 phosphorylation site [posttranslational modification] 522373010014 intermolecular recognition site; other site 522373010015 dimerization interface [polypeptide binding]; other site 522373010016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373010017 dimerization interface [polypeptide binding]; other site 522373010018 DNA binding residues [nucleotide binding] 522373010019 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3e-19 522373010020 HMMPfam hit to PF08281, Sigma-70, region, score 3.6e-05 522373010021 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.2e-31 522373010022 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 522373010023 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 522373010024 acyl-activating enzyme (AAE) consensus motif; other site 522373010025 AMP binding site [chemical binding]; other site 522373010026 active site 522373010027 CoA binding site [chemical binding]; other site 522373010028 HMMPfam hit to PF00501, AMP-binding enzyme, score 2e-97 522373010029 Predicted flavoprotein [General function prediction only]; Region: COG0431 522373010030 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373010031 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 7.8e-19 522373010032 Transcriptional regulators [Transcription]; Region: FadR; COG2186 522373010033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373010034 DNA-binding site [nucleotide binding]; DNA binding site 522373010035 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 522373010036 HMMPfam hit to PF07729, FCD domain, score 5.1e-27 522373010037 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.1e-24 522373010038 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 522373010039 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373010040 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373010041 HMMPfam hit to PF00593, TonB dependent receptor, score 4.3e-20 522373010042 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.9e-13 522373010043 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 522373010044 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 522373010045 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 522373010046 HMMPfam hit to PF07940, Heparinase II/III-like protein, score 2.4e-18 522373010047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373010048 putative substrate translocation pore; other site 522373010049 11 probable transmembrane helices predicted for Smlt2603 by TMHMM2.0 at aa 17-36, 59-81, 88-110, 150-172, 179-196, 254-271, 278-300, 315-334, 339-361, 371-393 and 400-422 522373010050 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-62 522373010051 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 522373010052 classical (c) SDRs; Region: SDR_c; cd05233 522373010053 NAD(P) binding site [chemical binding]; other site 522373010054 active site 522373010055 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.8e-24 522373010056 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 522373010057 active site 522373010058 catalytic triad [active] 522373010059 oxyanion hole [active] 522373010060 1 probable transmembrane helix predicted for Smlt2605 by TMHMM2.0 at aa 7-29 522373010061 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 2.3e-18 522373010062 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 522373010063 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 522373010064 substrate binding site [chemical binding]; other site 522373010065 ATP binding site [chemical binding]; other site 522373010066 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 8.4e-31 522373010067 2 probable transmembrane helices predicted for Smlt2607 by TMHMM2.0 at aa 63-85 and 95-117 522373010068 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 522373010069 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 522373010070 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373010071 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 522373010072 HMMPfam hit to PF08530, X-Pro dipeptidyl-peptidase C-terminal n, score 6.4e-22 522373010073 HMMPfam hit to PF02129, X-Pro dipeptidyl-peptidase (S15 family), score 3.1e-36 522373010074 1 probable transmembrane helix predicted for Smlt2609 by TMHMM2.0 at aa 21-40 522373010075 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 522373010076 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 522373010077 active site 522373010078 substrate binding site [chemical binding]; other site 522373010079 Mg2+ binding site [ion binding]; other site 522373010080 1 probable transmembrane helix predicted for Smlt2611 by TMHMM2.0 at aa 17-39 522373010081 HMMPfam hit to PF01223, DNA/RNA non-specific endonuclease, score 3.5e-37 522373010082 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 522373010083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373010084 active site 522373010085 motif I; other site 522373010086 motif II; other site 522373010087 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.3e-26 522373010088 2 probable transmembrane helices predicted for Smlt2613 by TMHMM2.0 at aa 13-32 and 37-59 522373010089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373010090 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 522373010091 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 4.2e-12 522373010092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373010093 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 522373010094 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3.5e-06 522373010095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373010096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373010097 dimerization interface [polypeptide binding]; other site 522373010098 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-25 522373010099 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 522373010100 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 522373010101 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.19 522373010102 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 1.7e-08 522373010103 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 1.2e-07 522373010104 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.29 522373010105 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 522373010106 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 522373010107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373010108 Walker A motif; other site 522373010109 ATP binding site [chemical binding]; other site 522373010110 Walker B motif; other site 522373010111 arginine finger; other site 522373010112 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 522373010113 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 5.6e-07 522373010114 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.3e-135 522373010115 HMMPfam hit to PF07728, ATPase family associated with various, score 0.00028 522373010116 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 522373010117 putative active site [active] 522373010118 HMMPfam hit to PF03412, Peptidase C39 family, score 3.1e-11 522373010119 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 522373010120 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 522373010121 Short C-terminal domain; Region: SHOCT; pfam09851 522373010122 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 522373010123 1 probable transmembrane helix predicted for Smlt2629 by TMHMM2.0 at aa 427-449 522373010124 1 probable transmembrane helix predicted for Smlt2630 by TMHMM2.0 at aa 5-24 522373010125 Protease inhibitor Inh; Region: Inh; pfam02974 522373010126 Cation efflux family; Region: Cation_efflux; pfam01545 522373010127 5 probable transmembrane helices predicted for Smlt2632 by TMHMM2.0 at aa 9-31, 78-100, 113-135, 160-182 and 189-211 522373010128 HMMPfam hit to PF01545, Cation efflux family, score 6.9e-73 522373010129 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 522373010130 active site 522373010131 DNA binding site [nucleotide binding] 522373010132 HMMPfam hit to PF02245, Methylpurine-DNA glycosylase (MPG), score 4.4e-63 522373010133 GAF domain; Region: GAF; pfam01590 522373010134 GAF domain; Region: GAF_2; pfam13185 522373010135 PAS domain S-box; Region: sensory_box; TIGR00229 522373010136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373010137 putative active site [active] 522373010138 heme pocket [chemical binding]; other site 522373010139 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373010140 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373010141 metal binding site [ion binding]; metal-binding site 522373010142 active site 522373010143 I-site; other site 522373010144 HMMPfam hit to PF01590, GAF domain, score 2.1e-17 522373010145 HMMPfam hit to PF08447, PAS fold, score 5.6e-05 522373010146 HMMPfam hit to PF08448, PAS fold, score 2.1e-06 522373010147 HMMPfam hit to PF00990, GGDEF domain, score 5.7e-18 522373010148 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 522373010149 putative catalytic site [active] 522373010150 putative phosphate binding site [ion binding]; other site 522373010151 active site 522373010152 metal binding site A [ion binding]; metal-binding site 522373010153 DNA binding site [nucleotide binding] 522373010154 putative AP binding site [nucleotide binding]; other site 522373010155 putative metal binding site B [ion binding]; other site 522373010156 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 9.9e-40 522373010157 trehalose synthase; Region: treS_nterm; TIGR02456 522373010158 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 522373010159 active site 522373010160 catalytic site [active] 522373010161 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 2.7e-33 522373010162 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 522373010163 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 522373010164 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 522373010165 HMMPfam hit to PF07100, Protein of unknown function (DUF1362), score 6.9e-72 522373010166 short chain dehydrogenase; Provisional; Region: PRK06701 522373010167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373010168 NAD(P) binding site [chemical binding]; other site 522373010169 active site 522373010170 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.7e-30 522373010171 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 522373010172 Mechanosensitive ion channel; Region: MS_channel; pfam00924 522373010173 3 probable transmembrane helices predicted for Smlt2641 by TMHMM2.0 at aa 15-37, 61-78 and 93-115 522373010174 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 522373010175 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 522373010176 Walker A/P-loop; other site 522373010177 ATP binding site [chemical binding]; other site 522373010178 Q-loop/lid; other site 522373010179 ABC transporter signature motif; other site 522373010180 Walker B; other site 522373010181 D-loop; other site 522373010182 H-loop/switch region; other site 522373010183 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373010184 FtsX-like permease family; Region: FtsX; pfam02687 522373010185 HMMPfam hit to PF02687, Predicted permease, score 9.2e-47 522373010186 5 probable transmembrane helices predicted for Smlt2642 by TMHMM2.0 at aa 273-295, 434-456, 523-545, 571-593 and 608-630 522373010187 HMMPfam hit to PF00005, ABC transporter score 6e-54 522373010188 macrolide transporter subunit MacA; Provisional; Region: PRK11578 522373010189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373010190 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373010191 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00025 522373010192 1 probable transmembrane helix predicted for Smlt2643 by TMHMM2.0 at aa 72-91 522373010193 1 probable transmembrane helix predicted for Smlt2644 by TMHMM2.0 at aa 50-72 522373010194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373010195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373010196 active site 522373010197 phosphorylation site [posttranslational modification] 522373010198 intermolecular recognition site; other site 522373010199 dimerization interface [polypeptide binding]; other site 522373010200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373010201 DNA binding site [nucleotide binding] 522373010202 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.7e-38 522373010203 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.5e-08 522373010204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373010205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 522373010206 dimerization interface [polypeptide binding]; other site 522373010207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373010208 dimer interface [polypeptide binding]; other site 522373010209 phosphorylation site [posttranslational modification] 522373010210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373010211 ATP binding site [chemical binding]; other site 522373010212 Mg2+ binding site [ion binding]; other site 522373010213 G-X-G motif; other site 522373010214 2 probable transmembrane helices predicted for Smlt2646 by TMHMM2.0 at aa 21-43 and 69-91 522373010215 HMMPfam hit to PF00672, HAMP domain, score 3.1e-09 522373010216 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.7e-11 522373010217 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.2e-34 522373010218 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 522373010219 5 probable transmembrane helices predicted for Smlt2647 by TMHMM2.0 at aa 87-109, 114-136, 191-210, 214-233 and 282-304 522373010220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 522373010221 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 522373010222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373010223 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 522373010224 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373010225 N-terminal plug; other site 522373010226 ligand-binding site [chemical binding]; other site 522373010227 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.9e-18 522373010228 HMMPfam hit to PF00593, TonB dependent receptor, score 7.1e-21 522373010229 conjugal transfer protein TrbP; Provisional; Region: PRK13882 522373010230 TraX protein; Region: TraX; pfam05857 522373010231 4 probable transmembrane helices predicted for Smlt2652 by TMHMM2.0 at aa 93-115, 130-152, 159-181 and 201-220 522373010232 HMMPfam hit to PF05857, TraX protein, score 1.5e-45 522373010233 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 522373010234 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 522373010235 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.4e-22 522373010236 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 522373010237 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 522373010238 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 522373010239 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 522373010240 Soluble P-type ATPase [General function prediction only]; Region: COG4087 522373010241 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 522373010242 HMMPfam hit to PF00690, Cation transporter/ATPase, N-terminus, score 7e-15 522373010243 HMMPfam hit to PF00122, E1-E2 ATPase, score 8.7e-77 522373010244 7 probable transmembrane helices predicted for Smlt2655 by TMHMM2.0 at aa 323-345, 352-374, 745-767, 803-825, 835-856, 863-885 and 900-922 522373010245 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.8e-15 522373010246 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 522373010247 MgtC family; Region: MgtC; pfam02308 522373010248 4 probable transmembrane helices predicted for Smlt2656 by TMHMM2.0 at aa 10-32, 44-63, 78-95 and 116-138 522373010249 HMMPfam hit to PF02308, MgtC family, score 1.1e-51 522373010250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373010251 dimer interface [polypeptide binding]; other site 522373010252 phosphorylation site [posttranslational modification] 522373010253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373010254 ATP binding site [chemical binding]; other site 522373010255 Mg2+ binding site [ion binding]; other site 522373010256 G-X-G motif; other site 522373010257 3 probable transmembrane helices predicted for Smlt2657 by TMHMM2.0 at aa 68-87, 107-129 and 136-158 522373010258 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2e-09 522373010259 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.8e-31 522373010260 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 522373010261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373010262 active site 522373010263 phosphorylation site [posttranslational modification] 522373010264 intermolecular recognition site; other site 522373010265 dimerization interface [polypeptide binding]; other site 522373010266 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373010267 DNA binding residues [nucleotide binding] 522373010268 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.5e-30 522373010269 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 2.3e-11 522373010270 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 522373010271 HMMPfam hit to PF08002, Protein of unknown function (DUF1697), score 3.2e-43 522373010272 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 522373010273 Predicted membrane protein [Function unknown]; Region: COG2510 522373010274 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 9.6e-24 522373010275 5 probable transmembrane helices predicted for Smlt2661 by TMHMM2.0 at aa 30-52, 59-78, 93-111, 123-142 and 147-164 522373010276 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 522373010277 HMMPfam hit to PF06772, Bacterial low temperature requirement A prot, score 8.5e-84 522373010278 12 probable transmembrane helices predicted for Smlt2662 by TMHMM2.0 at aa 20-39, 49-71, 84-103, 108-130, 143-162, 167-189, 210-227, 237-259, 280-297, 307-329, 334-356 and 360-379 522373010279 3 probable transmembrane helices predicted for Smlt2663 by TMHMM2.0 at aa 2-24, 29-51 and 63-85 522373010280 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 522373010281 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 522373010282 HMMPfam hit to PF04542, Sigma-70 region, score 0.00052 522373010283 HMMPfam hit to PF08281, Sigma-70, region, score 8.6e-13 522373010284 HMMPfam hit to PF04545, Sigma-70, region, score 2e-06 522373010285 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 522373010286 FecR protein; Region: FecR; pfam04773 522373010287 HMMPfam hit to PF04773, FecR protein, score 2.5e-29 522373010288 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373010289 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373010290 HMMPfam hit to PF07660, Secretin and TonB N terminus short domai, score 1.8e-09 522373010291 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.7e-12 522373010292 HMMPfam hit to PF00593, TonB dependent receptor, score 2.2e-18 522373010293 1 probable transmembrane helix predicted for Smlt2667 by TMHMM2.0 at aa 37-59 522373010294 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 522373010295 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 7.6e-22 522373010296 Predicted metal-binding protein [General function prediction only]; Region: COG3019 522373010297 HMMPfam hit to PF04214, Protein of unknown function, DUF, score 1.6e-40 522373010298 1 probable transmembrane helix predicted for Smlt2669 by TMHMM2.0 at aa 27-49 522373010299 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 522373010300 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 522373010301 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 522373010302 putative molybdopterin cofactor binding site [chemical binding]; other site 522373010303 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 522373010304 putative molybdopterin cofactor binding site; other site 522373010305 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 5e-05 522373010306 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 6.6e-09 522373010307 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 522373010308 HMMPfam hit to PF02634, FdhD/NarQ family, score 1.1e-69 522373010309 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 522373010310 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 522373010311 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 3.2e-12 522373010312 Cupin; Region: Cupin_6; pfam12852 522373010313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373010314 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 522373010315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373010316 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.5e-06 522373010317 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2e-05 522373010318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373010319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373010320 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 7.8e-13 522373010321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373010322 putative substrate translocation pore; other site 522373010323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373010324 14 probable transmembrane helices predicted for Smlt2678 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 112-134, 147-169, 174-196, 209-231, 235-254, 275-297, 312-334, 341-363, 368-390, 411-433 and 473-495 522373010325 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-50 522373010326 1 probable transmembrane helix predicted for Smlt2679 by TMHMM2.0 at aa 5-22 522373010327 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 522373010328 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 522373010329 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373010330 FtsX-like permease family; Region: FtsX; pfam02687 522373010331 HMMPfam hit to PF02687, Predicted permease, score 6.2e-18 522373010332 4 probable transmembrane helices predicted for Smlt2682 by TMHMM2.0 at aa 17-36, 290-312, 333-355 and 386-408 522373010333 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 522373010334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373010335 Walker A/P-loop; other site 522373010336 ATP binding site [chemical binding]; other site 522373010337 Q-loop/lid; other site 522373010338 ABC transporter signature motif; other site 522373010339 Walker B; other site 522373010340 D-loop; other site 522373010341 H-loop/switch region; other site 522373010342 HMMPfam hit to PF00005, ABC transporter score 3.9e-46 522373010343 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 522373010344 3 probable transmembrane helices predicted for Smlt2685 by TMHMM2.0 at aa 30-49, 56-75 and 79-101 522373010345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373010346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373010347 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 522373010348 putative effector binding pocket; other site 522373010349 dimerization interface [polypeptide binding]; other site 522373010350 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.3e-46 522373010351 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.1e-16 522373010352 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 522373010353 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 522373010354 active site 522373010355 catalytic tetrad [active] 522373010356 HMMPfam hit to PF00248, Aldo/keto reductase family, score 1e-90 522373010357 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 522373010358 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 522373010359 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 6.7e-05 522373010360 Putative cyclase; Region: Cyclase; pfam04199 522373010361 CopC domain; Region: CopC; pfam04234 522373010362 HMMPfam hit to PF04234, Copper resistance protein CopC, score 4.6e-28 522373010363 1 probable transmembrane helix predicted for Smlt2691 by TMHMM2.0 at aa 33-55 522373010364 HMMPfam hit to PF05425, Copper resistance protein D, score 1.3e-28 522373010365 8 probable transmembrane helices predicted for Smlt2692 by TMHMM2.0 at aa 10-27, 34-52, 83-105, 110-129, 144-166, 187-209, 224-246 and 266-288 522373010366 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 522373010367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373010368 active site 522373010369 phosphorylation site [posttranslational modification] 522373010370 intermolecular recognition site; other site 522373010371 dimerization interface [polypeptide binding]; other site 522373010372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373010373 DNA binding site [nucleotide binding] 522373010374 HMMPfam hit to PF00072, Response regulator receiver domain, score 6e-40 522373010375 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.4e-23 522373010376 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 522373010377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373010378 dimer interface [polypeptide binding]; other site 522373010379 phosphorylation site [posttranslational modification] 522373010380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373010381 ATP binding site [chemical binding]; other site 522373010382 Mg2+ binding site [ion binding]; other site 522373010383 G-X-G motif; other site 522373010384 2 probable transmembrane helices predicted for Smlt2694 by TMHMM2.0 at aa 12-34 and 158-180 522373010385 HMMPfam hit to PF00672, HAMP domain, score 7.4e-15 522373010386 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.3e-14 522373010387 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.1e-33 522373010388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373010389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373010390 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 522373010391 putative effector binding pocket; other site 522373010392 putative dimerization interface [polypeptide binding]; other site 522373010393 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.7e-45 522373010394 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.3e-18 522373010395 short chain dehydrogenase; Provisional; Region: PRK12937 522373010396 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 522373010397 NADP binding site [chemical binding]; other site 522373010398 homodimer interface [polypeptide binding]; other site 522373010399 active site 522373010400 substrate binding site [chemical binding]; other site 522373010401 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.3e-31 522373010402 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 3.8e-06 522373010403 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 522373010404 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 5.4e-289 522373010405 12 probable transmembrane helices predicted for Smlt2697 by TMHMM2.0 at aa 13-35, 333-352, 359-381, 391-413, 434-456, 471-493, 526-543, 861-880, 887-909, 913-935, 962-984 and 994-1016 522373010406 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373010407 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 522373010408 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373010409 Outer membrane efflux protein; Region: OEP; pfam02321 522373010410 Outer membrane efflux protein; Region: OEP; pfam02321 522373010411 HMMPfam hit to PF02321, Outer membrane efflux protein, score 4e-09 522373010412 HMMPfam hit to PF02321, Outer membrane efflux protein, score 6.3e-07 522373010413 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 522373010414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373010415 active site 522373010416 phosphorylation site [posttranslational modification] 522373010417 intermolecular recognition site; other site 522373010418 dimerization interface [polypeptide binding]; other site 522373010419 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373010420 DNA binding site [nucleotide binding] 522373010421 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.8e-31 522373010422 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 4.5e-22 522373010423 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 522373010424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373010425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373010426 dimer interface [polypeptide binding]; other site 522373010427 phosphorylation site [posttranslational modification] 522373010428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373010429 ATP binding site [chemical binding]; other site 522373010430 Mg2+ binding site [ion binding]; other site 522373010431 G-X-G motif; other site 522373010432 2 probable transmembrane helices predicted for Smlt2701 by TMHMM2.0 at aa 26-48 and 173-195 522373010433 HMMPfam hit to PF08521, Two-component sensor kinase N-terminal, score 2.4e-24 522373010434 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 8.5e-15 522373010435 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.2e-24 522373010436 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 522373010437 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 522373010438 HMMPfam hit to PF07971, Glycosyl hydrolase family, score 9.7e-288 522373010439 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 522373010440 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373010441 catalytic residues [active] 522373010442 HMMPfam hit to PF00085, Thioredoxin, score 0.0032 522373010443 Protein required for attachment to host cells; Region: Host_attach; pfam10116 522373010444 proline/glycine betaine transporter; Provisional; Region: PRK10642 522373010445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373010446 putative substrate translocation pore; other site 522373010447 HMMPfam hit to PF00083, Sugar (and other) transporter score 1.3e-48 522373010448 12 probable transmembrane helices predicted for Smlt2706 by TMHMM2.0 at aa 56-78, 93-115, 128-146, 161-183, 196-218, 228-247, 285-307, 322-344, 351-373, 383-405, 412-434 and 444-463 522373010449 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.1e-33 522373010450 1 probable transmembrane helix predicted for Smlt2707 by TMHMM2.0 at aa 7-29 522373010451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 522373010452 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 522373010453 PAS domain; Region: PAS_9; pfam13426 522373010454 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 522373010455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 522373010456 HWE histidine kinase; Region: HWE_HK; smart00911 522373010457 HMMPfam hit to PF07536, HWE histidine kinase, score 4.3e-19 522373010458 HMMPfam hit to PF08448, PAS fold, score 1.1e-07 522373010459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373010460 active site 522373010461 phosphorylation site [posttranslational modification] 522373010462 intermolecular recognition site; other site 522373010463 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.1e-05 522373010464 Tetratricopeptide repeat; Region: TPR_16; pfam13432 522373010465 Protein of unknown function (DUF560); Region: DUF560; pfam04575 522373010466 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 522373010467 1 probable transmembrane helix predicted for Smlt2713 by TMHMM2.0 at aa 7-29 522373010468 Secretin and TonB N terminus short domain; Region: STN; smart00965 522373010469 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 522373010470 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 522373010471 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373010472 HMMPfam hit to PF00593, TonB dependent receptor, score 2.8e-22 522373010473 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.4e-11 522373010474 HMMPfam hit to PF07660, Secretin and TonB N terminus short domai, score 3.2e-05 522373010475 1 probable transmembrane helix predicted for Smlt2714 by TMHMM2.0 at aa 12-34 522373010476 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 522373010477 FecR protein; Region: FecR; pfam04773 522373010478 HMMPfam hit to PF04773, FecR protein, score 1.9e-28 522373010479 1 probable transmembrane helix predicted for Smlt2715 by TMHMM2.0 at aa 113-135 522373010480 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 522373010481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373010482 DNA binding residues [nucleotide binding] 522373010483 HMMPfam hit to PF08281, Sigma-70, region, score 4.7e-13 522373010484 LysR family transcriptional regulator; Provisional; Region: PRK14997 522373010485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373010486 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 522373010487 putative effector binding pocket; other site 522373010488 putative dimerization interface [polypeptide binding]; other site 522373010489 HMMPfam hit to PF03466, LysR substrate binding domain, score 4e-38 522373010490 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1e-16 522373010491 Pirin-related protein [General function prediction only]; Region: COG1741 522373010492 Pirin; Region: Pirin; pfam02678 522373010493 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 522373010494 HMMPfam hit to PF02678, Pirin, score 7.1e-52 522373010495 HMMPfam hit to PF05726, Pirin C-terminal cupin domain, score 4.3e-45 522373010496 Isochorismatase family; Region: Isochorismatase; pfam00857 522373010497 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 522373010498 catalytic triad [active] 522373010499 dimer interface [polypeptide binding]; other site 522373010500 conserved cis-peptide bond; other site 522373010501 HMMPfam hit to PF00857, Isochorismatase family, score 1.5e-15 522373010502 Isochorismatase family; Region: Isochorismatase; pfam00857 522373010503 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 522373010504 catalytic triad [active] 522373010505 dimer interface [polypeptide binding]; other site 522373010506 conserved cis-peptide bond; other site 522373010507 HMMPfam hit to PF00857, Isochorismatase family, score 1.2e-08 522373010508 OsmC-like protein; Region: OsmC; pfam02566 522373010509 HMMPfam hit to PF02566, OsmC-like protein, score 7.2e-27 522373010510 1 probable transmembrane helix predicted for Smlt2724 by TMHMM2.0 at aa 30-49 522373010511 TonB C terminal; Region: TonB_2; pfam13103 522373010512 1 probable transmembrane helix predicted for Smlt2725 by TMHMM2.0 at aa 19-41 522373010513 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 522373010514 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 522373010515 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 3e-30 522373010516 1 probable transmembrane helix predicted for Smlt2726 by TMHMM2.0 at aa 21-43 522373010517 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 522373010518 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 522373010519 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 522373010520 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 1.5e-29 522373010521 3 probable transmembrane helices predicted for Smlt2727 by TMHMM2.0 at aa 369-391, 503-525 and 535-557 522373010522 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 522373010523 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 522373010524 Surface antigen; Region: Bac_surface_Ag; pfam01103 522373010525 HMMPfam hit to PF01103, Surface antigen, score 1.3e-05 522373010526 HMMPfam hit to PF08479, POTRA domain, ShlB-type, score 3.3e-15 522373010527 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 522373010528 1 probable transmembrane helix predicted for Smlt2730 by TMHMM2.0 at aa 17-36 522373010529 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 522373010530 Type II transport protein GspH; Region: GspH; pfam12019 522373010531 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 6.7e-05 522373010532 1 probable transmembrane helix predicted for Smlt2731 by TMHMM2.0 at aa 13-35 522373010533 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 522373010534 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 4.9e-08 522373010535 1 probable transmembrane helix predicted for Smlt2732 by TMHMM2.0 at aa 13-35 522373010536 HMMPfam hit to PF02501, Bacterial type II secretion system protein I, score 0.035 522373010537 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 522373010538 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 522373010539 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 522373010540 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 2.7e-07 522373010541 1 probable transmembrane helix predicted for Smlt2733 by TMHMM2.0 at aa 7-26 522373010542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373010543 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373010544 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373010545 HMMPfam hit to PF01548, Transposase, score 2.6e-10 522373010546 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 2e-24 522373010547 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 522373010548 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 522373010549 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.45 522373010550 HMMPfam hit to PF05860, haemagglutination activity domain, score 4.2e-27 522373010551 PBP superfamily domain; Region: PBP_like_2; cl17296 522373010552 1 probable transmembrane helix predicted for Smlt2738 by TMHMM2.0 at aa 7-29 522373010553 type II secretion system protein F; Region: GspF; TIGR02120 522373010554 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 522373010555 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 522373010556 3 probable transmembrane helices predicted for Smlt2740 by TMHMM2.0 at aa 164-186, 218-237 and 370-392 522373010557 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 1.1e-20 522373010558 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 5.4e-24 522373010559 type II secretion system protein E; Region: type_II_gspE; TIGR02533 522373010560 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 522373010561 Walker A motif; other site 522373010562 ATP binding site [chemical binding]; other site 522373010563 Walker B motif; other site 522373010564 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 5.3e-127 522373010565 type II secretion system protein D; Region: type_II_gspD; TIGR02517 522373010566 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 522373010567 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 522373010568 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 522373010569 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 522373010570 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 4.4e-92 522373010571 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 4.4e-10 522373010572 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 5.2e-10 522373010573 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 4.4e-11 522373010574 1 probable transmembrane helix predicted for Smlt2742 by TMHMM2.0 at aa 5-27 522373010575 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 522373010576 HMMPfam hit to PF04612, General secretion pathway, M protein, score 1.1e-07 522373010577 1 probable transmembrane helix predicted for Smlt2743 by TMHMM2.0 at aa 28-47 522373010578 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 522373010579 HMMPfam hit to PF05134, General secretion pathway protein L (GspL), score 2.6e-13 522373010580 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 522373010581 1 probable transmembrane helix predicted for Smlt2745 by TMHMM2.0 at aa 13-35 522373010582 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 522373010583 HMMPfam hit to PF08334, Bacterial type II secretion system protein G, score 6.7e-54 522373010584 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 3.8e-08 522373010585 1 probable transmembrane helix predicted for Smlt2746 by TMHMM2.0 at aa 13-35 522373010586 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 522373010587 FecR protein; Region: FecR; pfam04773 522373010588 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 522373010589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373010590 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 522373010591 HMMPfam hit to PF08281, Sigma-70, region, score 6e-08 522373010592 HMMPfam hit to PF04542, Sigma-70 region, score 3.4e-08 522373010593 Gram-negative bacterial tonB protein; Region: TonB; cl10048 522373010594 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 522373010595 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373010596 putative DNA binding site [nucleotide binding]; other site 522373010597 putative Zn2+ binding site [ion binding]; other site 522373010598 AsnC family; Region: AsnC_trans_reg; pfam01037 522373010599 HMMPfam hit to PF01037, AsnC family, score 1.7e-27 522373010600 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 522373010601 5 probable transmembrane helices predicted for Smlt2754 by TMHMM2.0 at aa 49-71, 94-116, 161-183, 198-215 and 228-250 522373010602 HMMPfam hit to PF03591, AzlC protein, score 1.8e-58 522373010603 Predicted membrane protein [Function unknown]; Region: COG4541 522373010604 3 probable transmembrane helices predicted for Smlt2755 by TMHMM2.0 at aa 10-32, 45-64 and 79-101 522373010605 HMMPfam hit to PF05437, Branched-chain amino acid transport protein, score 8.3e-29 522373010606 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 522373010607 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 522373010608 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 522373010609 active site 522373010610 catalytic site [active] 522373010611 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 1.6e-12 522373010612 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 4.2e-34 522373010613 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 522373010614 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 522373010615 active site 522373010616 catalytic site [active] 522373010617 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 1.9e-07 522373010618 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 522373010619 HMMPfam hit to PF02446, 4-alpha-glucanotransferase, score 1.2e-59 522373010620 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 522373010621 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 522373010622 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 522373010623 catalytic site [active] 522373010624 active site 522373010625 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 522373010626 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 2.2e-10 522373010627 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 0.0072 522373010628 glycogen branching enzyme; Provisional; Region: PRK12568 522373010629 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 522373010630 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 522373010631 active site 522373010632 catalytic site [active] 522373010633 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 522373010634 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 5e-08 522373010635 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 1.9e-33 522373010636 glycogen synthase; Provisional; Region: glgA; PRK00654 522373010637 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 522373010638 ADP-binding pocket [chemical binding]; other site 522373010639 homodimer interface [polypeptide binding]; other site 522373010640 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.4e-13 522373010641 HMMPfam hit to PF08323, Starch synthase catalytic domain, score 8.2e-84 522373010642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373010643 PAS domain; Region: PAS_9; pfam13426 522373010644 putative active site [active] 522373010645 heme pocket [chemical binding]; other site 522373010646 HMMPfam hit to PF00989, PAS fold, score 1.7e-09 522373010647 HMMPfam hit to PF08447, PAS fold, score 2.8e-12 522373010648 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 522373010649 Flavodoxin; Region: Flavodoxin_1; pfam00258 522373010650 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 522373010651 FAD binding pocket [chemical binding]; other site 522373010652 conserved FAD binding motif [chemical binding]; other site 522373010653 phosphate binding motif [ion binding]; other site 522373010654 beta-alpha-beta structure motif; other site 522373010655 NAD binding pocket [chemical binding]; other site 522373010656 HMMPfam hit to PF00258, Flavodoxin, score 4.2e-28 522373010657 HMMPfam hit to PF00667, FAD binding domain, score 6.8e-09 522373010658 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 2e-21 522373010659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373010660 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 522373010661 Walker A/P-loop; other site 522373010662 ATP binding site [chemical binding]; other site 522373010663 Q-loop/lid; other site 522373010664 ABC transporter signature motif; other site 522373010665 Walker B; other site 522373010666 D-loop; other site 522373010667 H-loop/switch region; other site 522373010668 HMMPfam hit to PF00005, ABC transporter score 2.2e-41 522373010669 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 522373010670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373010671 dimer interface [polypeptide binding]; other site 522373010672 conserved gate region; other site 522373010673 putative PBP binding loops; other site 522373010674 ABC-ATPase subunit interface; other site 522373010675 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.6e-29 522373010676 5 probable transmembrane helices predicted for Smlt2765 by TMHMM2.0 at aa 15-34, 46-68, 83-105, 133-155 and 196-218 522373010677 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 522373010678 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 522373010679 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 1.8e-08 522373010680 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 522373010681 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 522373010682 ligand binding site [chemical binding]; other site 522373010683 flexible hinge region; other site 522373010684 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 522373010685 putative switch regulator; other site 522373010686 non-specific DNA interactions [nucleotide binding]; other site 522373010687 DNA binding site [nucleotide binding] 522373010688 sequence specific DNA binding site [nucleotide binding]; other site 522373010689 putative cAMP binding site [chemical binding]; other site 522373010690 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 1.7e-09 522373010691 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 1.6e-15 522373010692 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 522373010693 HemN C-terminal domain; Region: HemN_C; pfam06969 522373010694 HMMPfam hit to PF06969, HemN C-terminal region, score 1.1e-14 522373010695 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 522373010696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373010697 putative substrate translocation pore; other site 522373010698 12 probable transmembrane helices predicted for Smlt2769 by TMHMM2.0 at aa 17-39, 54-73, 82-101, 106-128, 140-162, 166-188, 220-242, 252-274, 286-303, 318-340, 360-382 and 387-409 522373010699 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-52 522373010700 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 522373010701 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 9.9e-16 522373010702 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 522373010703 HMMPfam hit to PF02665, Nitrate reductase gamma subunit, score 1.3e-66 522373010704 5 probable transmembrane helices predicted for Smlt2771 by TMHMM2.0 at aa 10-27, 56-78, 88-110, 123-145 and 194-216 522373010705 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 522373010706 HMMPfam hit to PF02613, Nitrate reductase delta subunit, score 2.6e-52 522373010707 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 522373010708 4Fe-4S binding domain; Region: Fer4_6; pfam12837 522373010709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 522373010710 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0018 522373010711 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0035 522373010712 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 522373010713 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 522373010714 [4Fe-4S] binding site [ion binding]; other site 522373010715 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 522373010716 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 522373010717 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 522373010718 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 522373010719 molybdopterin cofactor binding site; other site 522373010720 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 3.1e-24 522373010721 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.9e-140 522373010722 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 522373010723 12 probable transmembrane helices predicted for Smlt2775 by TMHMM2.0 at aa 46-68, 83-105, 112-131, 135-157, 177-199, 219-241, 268-290, 300-318, 325-347, 357-379, 409-431 and 446-468 522373010724 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.9e-07 522373010725 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 522373010726 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 522373010727 GTP binding site; other site 522373010728 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 522373010729 MoaE homodimer interface [polypeptide binding]; other site 522373010730 MoaD interaction [polypeptide binding]; other site 522373010731 active site residues [active] 522373010732 HMMPfam hit to PF02391, MoaE protein, score 6.4e-26 522373010733 Ubiquitin-like proteins; Region: UBQ; cl00155 522373010734 charged pocket; other site 522373010735 hydrophobic patch; other site 522373010736 HMMPfam hit to PF02597, ThiS family, score 9.6e-05 522373010737 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 522373010738 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 522373010739 dimer interface [polypeptide binding]; other site 522373010740 putative functional site; other site 522373010741 putative MPT binding site; other site 522373010742 HMMPfam hit to PF03454, MoeA C-terminal region (domain IV), score 8.4e-07 522373010743 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 2.5e-43 522373010744 HMMPfam hit to PF03453, MoeA N-terminal region (domain I and II, score 4.1e-49 522373010745 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 522373010746 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 522373010747 trimer interface [polypeptide binding]; other site 522373010748 dimer interface [polypeptide binding]; other site 522373010749 putative active site [active] 522373010750 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 522373010751 MPT binding site; other site 522373010752 trimer interface [polypeptide binding]; other site 522373010753 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 8.1e-37 522373010754 HMMPfam hit to PF01967, MoaC family, score 4.2e-48 522373010755 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 522373010756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373010757 FeS/SAM binding site; other site 522373010758 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 522373010759 HMMPfam hit to PF06463, Molybdenum Cofactor Synthesis C, score 9e-41 522373010760 HMMPfam hit to PF04055, Radical SAM superfamily, score 1e-36 522373010761 3 probable transmembrane helices predicted for Smlt2784 by TMHMM2.0 at aa 20-42, 49-71 and 86-108 522373010762 1 probable transmembrane helix predicted for Smlt2788 by TMHMM2.0 at aa 51-73 522373010763 2 probable transmembrane helices predicted for Smlt2790 by TMHMM2.0 at aa 21-43 and 63-85 522373010764 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 522373010765 RHS Repeat; Region: RHS_repeat; pfam05593 522373010766 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 522373010767 RHS Repeat; Region: RHS_repeat; pfam05593 522373010768 RHS Repeat; Region: RHS_repeat; cl11982 522373010769 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 522373010770 HMMPfam hit to PF05593, RHS Repeat, score 4.1 522373010771 HMMPfam hit to PF05593, RHS Repeat, score 0.005 522373010772 HMMPfam hit to PF05593, RHS Repeat, score 0.032 522373010773 HMMPfam hit to PF05593, RHS Repeat, score 0.00011 522373010774 HMMPfam hit to PF05593, RHS Repeat, score 0.0026 522373010775 HMMPfam hit to PF05593, RHS Repeat, score 0.00033 522373010776 HMMPfam hit to PF05593, RHS Repeat, score 0.0048 522373010777 HMMPfam hit to PF05593, RHS Repeat, score 0.022 522373010778 HMMPfam hit to PF05593, RHS Repeat, score 1.5e-07 522373010779 HMMPfam hit to PF05593, RHS Repeat, score 1.8 522373010780 HMMPfam hit to PF05593, RHS Repeat, score 0.099 522373010781 HMMPfam hit to PF05593, RHS Repeat, score 0.0014 522373010782 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373010783 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 522373010784 catalytic site [active] 522373010785 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 6.7e-05 522373010786 Helix-turn-helix domain; Region: HTH_18; pfam12833 522373010787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373010788 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.00013 522373010789 HMMPfam hit to PF07883, Cupin domain, score 0.0013 522373010790 Fusaric acid resistance protein family; Region: FUSC; pfam04632 522373010791 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 522373010792 10 probable transmembrane helices predicted for Smlt2796 by TMHMM2.0 at aa 32-51, 80-102, 106-125, 132-149, 159-181, 351-370, 374-396, 401-423, 447-469 and 476-498 522373010793 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved re, score 1.8e-24 522373010794 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 522373010795 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373010796 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373010797 1 probable transmembrane helix predicted for Smlt2797 by TMHMM2.0 at aa 7-29 522373010798 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.7e-13 522373010799 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 522373010800 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.5e-17 522373010801 HMMPfam hit to PF02321, Outer membrane efflux protein, score 5.2e-25 522373010802 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 522373010803 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373010804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373010805 active site 522373010806 phosphorylation site [posttranslational modification] 522373010807 intermolecular recognition site; other site 522373010808 dimerization interface [polypeptide binding]; other site 522373010809 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373010810 DNA binding site [nucleotide binding] 522373010811 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.2e-34 522373010812 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 3.5e-13 522373010813 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 522373010814 HAMP domain; Region: HAMP; pfam00672 522373010815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373010816 dimer interface [polypeptide binding]; other site 522373010817 phosphorylation site [posttranslational modification] 522373010818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373010819 ATP binding site [chemical binding]; other site 522373010820 Mg2+ binding site [ion binding]; other site 522373010821 G-X-G motif; other site 522373010822 2 probable transmembrane helices predicted for Smlt2802 by TMHMM2.0 at aa 12-34 and 125-147 522373010823 HMMPfam hit to PF00672, HAMP domain, score 4.2e-06 522373010824 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.2e-08 522373010825 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 6.6e-23 522373010826 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 522373010827 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 1.2e-29 522373010828 3 probable transmembrane helices predicted for Smlt2803 by TMHMM2.0 at aa 39-58, 67-89 and 109-127 522373010829 putative metal dependent hydrolase; Provisional; Region: PRK11598 522373010830 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 522373010831 Sulfatase; Region: Sulfatase; pfam00884 522373010832 5 probable transmembrane helices predicted for Smlt2804 by TMHMM2.0 at aa 13-32, 47-69, 78-100, 120-142 and 154-176 522373010833 HMMPfam hit to PF08019, Domain of unknown function (DUF1705), score 7.6e-50 522373010834 HMMPfam hit to PF00884, Sulfatase, score 6.6e-75 522373010835 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 522373010836 putative active site [active] 522373010837 Zn binding site [ion binding]; other site 522373010838 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 522373010839 4 probable transmembrane helices predicted for Smlt2807 by TMHMM2.0 at aa 5-27, 31-53, 104-126 and 158-180 522373010840 HMMPfam hit to PF05650, Domain of unknown function (DUF802), score 4.9e-05 522373010841 hypothetical protein; Provisional; Region: PRK09040 522373010842 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 522373010843 ligand binding site [chemical binding]; other site 522373010844 1 probable transmembrane helix predicted for Smlt2808 by TMHMM2.0 at aa 15-37 522373010845 HMMPfam hit to PF00691, OmpA family, score 1.1e-20 522373010846 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 522373010847 Transposase IS200 like; Region: Y1_Tnp; pfam01797 522373010848 HMMPfam hit to PF07605, Protein of unknown function (DUF1568), score 3.7e-05 522373010849 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 522373010850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373010851 NAD(P) binding site [chemical binding]; other site 522373010852 active site 522373010853 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.00047 522373010854 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.9e-25 522373010855 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 522373010856 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 522373010857 acyl-activating enzyme (AAE) consensus motif; other site 522373010858 AMP binding site [chemical binding]; other site 522373010859 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 522373010860 HMMPfam hit to PF00975, Thioesterase domain, score 3e-23 522373010861 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 6.2e-12 522373010862 HMMPfam hit to PF00501, AMP-binding enzyme, score 2.9e-155 522373010863 HMMPfam hit to PF00668, Condensation domain, score 2.7e-11 522373010864 Phosphopantetheine attachment site; Region: PP-binding; cl09936 522373010865 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 6.2e-11 522373010866 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 522373010867 Isochorismatase family; Region: Isochorismatase; pfam00857 522373010868 catalytic triad [active] 522373010869 conserved cis-peptide bond; other site 522373010870 HMMPfam hit to PF00857, Isochorismatase family, score 1.1e-70 522373010871 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 522373010872 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 522373010873 acyl-activating enzyme (AAE) consensus motif; other site 522373010874 active site 522373010875 AMP binding site [chemical binding]; other site 522373010876 substrate binding site [chemical binding]; other site 522373010877 HMMPfam hit to PF00501, AMP-binding enzyme, score 9.5e-104 522373010878 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 522373010879 HMMPfam hit to PF00425, chorismate binding enzyme, score 4.7e-73 522373010880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373010881 putative substrate translocation pore; other site 522373010882 11 probable transmembrane helices predicted for Smlt2823 by TMHMM2.0 at aa 17-39, 54-73, 82-104, 124-146, 153-175, 201-223, 236-255, 265-283, 290-312, 322-344 and 351-370 522373010883 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.3e-37 522373010884 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 522373010885 3 probable transmembrane helices predicted for Smlt2824 by TMHMM2.0 at aa 60-82, 97-116 and 123-145 522373010886 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 522373010887 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 522373010888 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 522373010889 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 2.1e-07 522373010890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 522373010891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373010892 Coenzyme A binding pocket [chemical binding]; other site 522373010893 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.7e-12 522373010894 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 522373010895 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373010896 catalytic residues [active] 522373010897 HMMPfam hit to PF00085, Thioredoxin, score 0.00093 522373010898 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 522373010899 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 522373010900 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 522373010901 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 4.5e-52 522373010902 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 4.8e-60 522373010903 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 522373010904 HMMPfam hit to PF01613, Flavin reductase like domain, score 1.7e-43 522373010905 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.39 522373010906 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.044 522373010907 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 522373010908 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 522373010909 putative di-iron ligands [ion binding]; other site 522373010910 HMMPfam hit to PF00487, Fatty acid desaturase, score 1e-06 522373010911 4 probable transmembrane helices predicted for Smlt2831 by TMHMM2.0 at aa 46-68, 72-89, 163-185 and 222-244 522373010912 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 522373010913 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 522373010914 FAD binding pocket [chemical binding]; other site 522373010915 FAD binding motif [chemical binding]; other site 522373010916 phosphate binding motif [ion binding]; other site 522373010917 beta-alpha-beta structure motif; other site 522373010918 NAD binding pocket [chemical binding]; other site 522373010919 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 522373010920 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 522373010921 catalytic loop [active] 522373010922 iron binding site [ion binding]; other site 522373010923 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding doma, score 1e-10 522373010924 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.8e-12 522373010925 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 2.1e-10 522373010926 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 522373010927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373010928 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 4.3e-12 522373010929 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 522373010930 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 522373010931 Autotransporter beta-domain; Region: Autotransporter; smart00869 522373010932 HMMPfam hit to PF03212, Pertactin, score 0.00039 522373010933 HMMPfam hit to PF03797, Autotransporter beta-domain, score 8.6e-29 522373010934 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 522373010935 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373010936 N-terminal plug; other site 522373010937 ligand-binding site [chemical binding]; other site 522373010938 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 6.8e-15 522373010939 HMMPfam hit to PF00593, TonB dependent receptor, score 1e-14 522373010940 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 522373010941 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373010942 1 probable transmembrane helix predicted for Smlt2836 by TMHMM2.0 at aa 21-43 522373010943 manganese transport regulator MntR; Provisional; Region: PRK11050 522373010944 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 522373010945 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 522373010946 HMMPfam hit to PF02742, Iron dependent repressor, metal bindin, score 2.5e-07 522373010947 HMMPfam hit to PF01047, MarR family, score 0.00081 522373010948 HMMPfam hit to PF01325, Iron dependent repressor, N-terminal D, score 4.8e-12 522373010949 manganese transport protein MntH; Reviewed; Region: PRK00701 522373010950 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 522373010951 11 probable transmembrane helices predicted for Smlt2838 by TMHMM2.0 at aa 42-61, 76-98, 124-146, 156-173, 180-202, 226-245, 275-297, 312-334, 364-386, 390-412 and 419-441 522373010952 HMMPfam hit to PF01566, Natural resistance-associated macrophage pro, score 2.1e-161 522373010953 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 522373010954 catalytic residues [active] 522373010955 HMMPfam hit to PF00085, Thioredoxin, score 0.0007 522373010956 flavodoxin; Provisional; Region: PRK09271 522373010957 HMMPfam hit to PF00258, Flavodoxin, score 0.00026 522373010958 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 522373010959 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 522373010960 dimer interface [polypeptide binding]; other site 522373010961 putative radical transfer pathway; other site 522373010962 diiron center [ion binding]; other site 522373010963 tyrosyl radical; other site 522373010964 HMMPfam hit to PF00268, Ribonucleotide reductase, small chain, score 1.1e-14 522373010965 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 522373010966 Class I ribonucleotide reductase; Region: RNR_I; cd01679 522373010967 active site 522373010968 dimer interface [polypeptide binding]; other site 522373010969 catalytic residues [active] 522373010970 effector binding site; other site 522373010971 R2 peptide binding site; other site 522373010972 HMMPfam hit to PF02867, Ribonucleotide reductase, barrel doma, score 5.2e-127 522373010973 HMMPfam hit to PF00317, Ribonucleotide reductase, all-alpha d, score 7.9e-26 522373010974 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 522373010975 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 522373010976 putative NAD(P) binding site [chemical binding]; other site 522373010977 putative dimer interface [polypeptide binding]; other site 522373010978 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 3.4e-18 522373010979 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.6e-20 522373010980 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373010981 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373010982 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 6.1e-18 522373010983 HMMPfam hit to PF00593, TonB dependent receptor, score 1.2e-28 522373010984 BCCT family transporter; Region: BCCT; cl00569 522373010985 HMMPfam hit to PF02028, BCCT family transporter score 1.2e-194 522373010986 12 probable transmembrane helices predicted for Smlt2846 by TMHMM2.0 at aa 17-39, 49-71, 92-114, 144-166, 187-209, 232-254, 267-289, 316-338, 351-370, 411-433, 454-476 and 480-502 522373010987 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 522373010988 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373010989 RNA polymerase sigma factor; Provisional; Region: PRK12528 522373010990 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373010991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373010992 DNA binding residues [nucleotide binding] 522373010993 HMMPfam hit to PF04542, Sigma-70 region, score 1.6e-11 522373010994 HMMPfam hit to PF08281, Sigma-70, region, score 1.5e-16 522373010995 HMMPfam hit to PF04545, Sigma-70, region, score 1.8e-05 522373010996 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 522373010997 FecR protein; Region: FecR; pfam04773 522373010998 HMMPfam hit to PF04773, FecR protein, score 3e-27 522373010999 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373011000 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373011001 HMMPfam hit to PF07660, Secretin and TonB N terminus short domai, score 1.5e-05 522373011002 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.4e-15 522373011003 HMMPfam hit to PF00593, TonB dependent receptor, score 1.4e-18 522373011004 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 522373011005 4 probable transmembrane helices predicted for Smlt2851 by TMHMM2.0 at aa 5-24, 31-53, 58-80 and 87-106 522373011006 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 1.3e-20 522373011007 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 522373011008 4 probable transmembrane helices predicted for Smlt2852 by TMHMM2.0 at aa 12-34, 39-58, 65-87 and 97-114 522373011009 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 1.5e-21 522373011010 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373011011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373011012 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 522373011013 dimerization interface [polypeptide binding]; other site 522373011014 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 7e-19 522373011015 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-20 522373011016 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 522373011017 putative active site [active] 522373011018 Zn binding site [ion binding]; other site 522373011019 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 522373011020 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373011021 N-terminal plug; other site 522373011022 ligand-binding site [chemical binding]; other site 522373011023 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.6e-23 522373011024 HMMPfam hit to PF00593, TonB dependent receptor, score 6.2e-29 522373011025 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 522373011026 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 522373011027 Cl- selectivity filter; other site 522373011028 Cl- binding residues [ion binding]; other site 522373011029 pore gating glutamate residue; other site 522373011030 dimer interface [polypeptide binding]; other site 522373011031 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 522373011032 9 probable transmembrane helices predicted for Smlt2859 by TMHMM2.0 at aa 42-64, 84-106, 181-203, 208-230, 255-277, 329-351, 358-380, 390-412 and 419-441 522373011033 HMMPfam hit to PF00654, Voltage gated chloride channel, score 6e-10 522373011034 HMMPfam hit to PF00571, CBS domain pair, score 7.7e-06 522373011035 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 522373011036 MgtC family; Region: MgtC; pfam02308 522373011037 3 probable transmembrane helices predicted for Smlt2860 by TMHMM2.0 at aa 10-32, 45-64 and 68-87 522373011038 HMMPfam hit to PF02308, MgtC family, score 1.4e-46 522373011039 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 522373011040 DNA binding residues [nucleotide binding] 522373011041 HMMPfam hit to PF00376, MerR family regulatory protein, score 0.0027 522373011042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373011043 S-adenosylmethionine binding site [chemical binding]; other site 522373011044 HMMPfam hit to PF08241, Methyltransferase domain, score 7.4e-24 522373011045 HMMPfam hit to PF08242, Methyltransferase domain, score 6.9e-13 522373011046 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 522373011047 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 522373011048 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 522373011049 ligand binding site [chemical binding]; other site 522373011050 HMMPfam hit to PF00691, OmpA family, score 1.8e-22 522373011051 HMMPfam hit to PF04355, SmpA / OmlA family, score 1.6e-11 522373011052 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 522373011053 Haemagglutinin; Region: HIM; pfam05662 522373011054 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 522373011055 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 522373011056 YadA-like C-terminal region; Region: YadA; pfam03895 522373011057 HMMPfam hit to PF03895, YadA-like C-terminal region, score 1.2e-31 522373011058 HMMPfam hit to PF05662, Haemagglutinin, score 0.00012 522373011059 HMMPfam hit to PF05662, Haemagglutinin, score 4.2e-06 522373011060 HMMPfam hit to PF05658, Hep_Hag, score 0.54 522373011061 HMMPfam hit to PF05658, Hep_Hag, score 0.03 522373011062 HMMPfam hit to PF05662, Haemagglutinin, score 0.00021 522373011063 HMMPfam hit to PF05658, Hep_Hag, score 0.00099 522373011064 HMMPfam hit to PF05662, Haemagglutinin, score 1e-06 522373011065 HMMPfam hit to PF05658, Hep_Hag, score 7.9e-07 522373011066 HMMPfam hit to PF05662, Haemagglutinin, score 6.2e-07 522373011067 1 probable transmembrane helix predicted for Smlt2865 by TMHMM2.0 at aa 40-62 522373011068 Helix-turn-helix domain; Region: HTH_18; pfam12833 522373011069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373011070 Flp/Fap pilin component; Region: Flp_Fap; cl01585 522373011071 HMMPfam hit to PF04964, Flp/Fap pilin component, score 4e-08 522373011072 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 522373011073 5 probable transmembrane helices predicted for Smlt2868 by TMHMM2.0 at aa 2-19, 29-47, 54-76, 96-118 and 159-181 522373011074 HMMPfam hit to PF01478, Type IV leader peptidase family, score 6.9e-16 522373011075 HMMPfam hit to PF07811, TadE-like protein, score 1.5e-05 522373011076 1 probable transmembrane helix predicted for Smlt2869 by TMHMM2.0 at aa 13-35 522373011077 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 522373011078 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 522373011079 1 probable transmembrane helix predicted for Smlt2870 by TMHMM2.0 at aa 7-26 522373011080 HMMPfam hit to PF06981, Flp pilus assembly protein CpaB, score 2.4e-26 522373011081 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 522373011082 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 522373011083 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 522373011084 HMMPfam hit to PF00263, Bacterial type II and III secretion system p, score 6.8e-70 522373011085 AAA domain; Region: AAA_31; pfam13614 522373011086 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 522373011087 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 522373011088 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 522373011089 ATP binding site [chemical binding]; other site 522373011090 Walker A motif; other site 522373011091 hexamer interface [polypeptide binding]; other site 522373011092 Walker B motif; other site 522373011093 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 2.2e-100 522373011094 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 522373011095 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 522373011096 5 probable transmembrane helices predicted for Smlt2874 by TMHMM2.0 at aa 4-21, 88-105, 110-129, 257-276 and 291-310 522373011097 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 1.5e-14 522373011098 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 522373011099 4 probable transmembrane helices predicted for Smlt2875 by TMHMM2.0 at aa 28-50, 125-147, 152-174 and 302-324 522373011100 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 4.8e-15 522373011101 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 522373011102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373011103 TPR motif; other site 522373011104 binding surface 522373011105 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0015 522373011106 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 522373011107 putative exported protein, pseudogene;similarity:fasta; BB1833; bbronchiseptica; putative exported protein; length 747 aa; id=33.5%; E()=3e-39; 775 aa overlap; query 1-717 aa; subject 1-747 aa; similarity:fasta; BPP2383; bparapertussis; putative exported protein; length 749 aa; id=33.5%; E()=2.3e-40; 775 aa overlap; query 1-717 aa; subject 3-749 aa; similarity:fasta; BP2003; bpertussis; putative exported protein; length 747 aa; id=33.2%; E()=1.3e-39; 775 aa overlap; query 1-717 aa; subject 1-747 aa 522373011108 1 probable transmembrane helix predicted for Smlt2878 by TMHMM2.0 at aa 20-42 522373011109 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 522373011110 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 522373011111 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 522373011112 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373011113 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.5e-37 522373011114 Transmembrane secretion effector; Region: MFS_3; pfam05977 522373011115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373011116 putative substrate translocation pore; other site 522373011117 HMMPfam hit to PF05977, Bacterial protein of unknown function (DUF89, score 1e-225 522373011118 12 probable transmembrane helices predicted for Smlt2883 by TMHMM2.0 at aa 60-82, 92-114, 121-140, 150-172, 185-207, 211-233, 267-289, 299-318, 330-349, 354-376, 389-411 and 421-440 522373011119 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4e-34 522373011120 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 522373011121 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 522373011122 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 522373011123 active site 522373011124 HMMPfam hit to PF07969, Amidohydrolase family, score 4.2e-154 522373011125 4 probable transmembrane helices predicted for Smlt2886 by TMHMM2.0 at aa 12-34, 54-76, 83-102 and 112-131 522373011126 HMMPfam hit to PF07681, DoxX, score 5.1e-26 522373011127 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 522373011128 Isochorismatase family; Region: Isochorismatase; pfam00857 522373011129 catalytic triad [active] 522373011130 dimer interface [polypeptide binding]; other site 522373011131 conserved cis-peptide bond; other site 522373011132 HMMPfam hit to PF00857, Isochorismatase family, score 6.4e-09 522373011133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373011134 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 522373011135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373011136 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.1e-12 522373011137 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.5e-09 522373011138 2 probable transmembrane helices predicted for Smlt2889 by TMHMM2.0 at aa 75-97 and 107-129 522373011139 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 522373011140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 522373011141 Histidine kinase; Region: HisKA_3; pfam07730 522373011142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373011143 ATP binding site [chemical binding]; other site 522373011144 Mg2+ binding site [ion binding]; other site 522373011145 G-X-G motif; other site 522373011146 1 probable transmembrane helix predicted for Smlt2890 by TMHMM2.0 at aa 11-33 522373011147 HMMPfam hit to PF07494, Two component regulator propeller, score 0.049 522373011148 HMMPfam hit to PF07494, Two component regulator propeller, score 17 522373011149 HMMPfam hit to PF07494, Two component regulator propeller, score 3.7 522373011150 HMMPfam hit to PF07494, Two component regulator propeller, score 23 522373011151 HMMPfam hit to PF07494, Two component regulator propeller, score 15 522373011152 HMMPfam hit to PF07494, Two component regulator propeller, score 23 522373011153 HMMPfam hit to PF07494, Two component regulator propeller, score 1.1 522373011154 HMMPfam hit to PF07495, Y_Y_Y domain, score 6.5e-18 522373011155 HMMPfam hit to PF07730, Histidine kinase, score 7.6e-12 522373011156 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.4e-12 522373011157 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373011158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373011159 active site 522373011160 phosphorylation site [posttranslational modification] 522373011161 intermolecular recognition site; other site 522373011162 dimerization interface [polypeptide binding]; other site 522373011163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373011164 DNA binding residues [nucleotide binding] 522373011165 dimerization interface [polypeptide binding]; other site 522373011166 HMMPfam hit to PF00072, Response regulator receiver domain, score 3e-31 522373011167 HMMPfam hit to PF08281, Sigma-70, region, score 0.0019 522373011168 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 1.8e-21 522373011169 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 522373011170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373011171 putative substrate translocation pore; other site 522373011172 12 probable transmembrane helices predicted for Smlt2892 by TMHMM2.0 at aa 13-35, 55-77, 84-106, 111-133, 142-164, 174-193, 223-245, 255-277, 284-306, 319-341, 348-370 and 374-393 522373011173 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5e-34 522373011174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373011175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373011176 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373011177 putative effector binding pocket; other site 522373011178 dimerization interface [polypeptide binding]; other site 522373011179 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5e-23 522373011180 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.4e-46 522373011181 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 522373011182 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 522373011183 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 522373011184 active site 522373011185 HMMPfam hit to PF01979, Amidohydrolase family, score 0.001 522373011186 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373011187 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373011188 HMMPfam hit to PF00023, Ankyrin repeat, score 0.00036 522373011189 HMMPfam hit to PF00023, Ankyrin repeat, score 0.082 522373011190 HMMPfam hit to PF00023, Ankyrin repeat, score 1e-07 522373011191 HMMPfam hit to PF00023, Ankyrin repeat, score 16 522373011192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373011193 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 522373011194 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373011195 dimerization interface [polypeptide binding]; other site 522373011196 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.5e-18 522373011197 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.6e-35 522373011198 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 522373011199 cytosine deaminase; Provisional; Region: PRK05985 522373011200 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 522373011201 active site 522373011202 HMMPfam hit to PF01979, Amidohydrolase family, score 0.025 522373011203 HMMPfam hit to PF07969, Amidohydrolase family, score 2.5e-25 522373011204 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373011205 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 522373011206 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373011207 HMMPfam hit to PF00593, TonB dependent receptor, score 2.4e-23 522373011208 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 7.7e-21 522373011209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 522373011210 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 522373011211 HMMPfam hit to PF02611, CDP-diacylglycerol pyrophosphatase, score 8.9e-42 522373011212 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 522373011213 D-lactate dehydrogenase; Provisional; Region: PRK11183 522373011214 FAD binding domain; Region: FAD_binding_4; pfam01565 522373011215 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 522373011216 HMMPfam hit to PF01565, FAD binding domain, score 1.7e-05 522373011217 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 522373011218 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 522373011219 phosphate binding site [ion binding]; other site 522373011220 HMMPfam hit to PF01070, FMN-dependent dehydrogenase, score 1.9e-219 522373011221 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 522373011222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373011223 DNA-binding site [nucleotide binding]; DNA binding site 522373011224 FCD domain; Region: FCD; pfam07729 522373011225 HMMPfam hit to PF07729, FCD domain, score 1.5e-40 522373011226 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 6.2e-22 522373011227 L-lactate permease; Provisional; Region: PRK10420 522373011228 glycolate transporter; Provisional; Region: PRK09695 522373011229 13 probable transmembrane helices predicted for Smlt2910 by TMHMM2.0 at aa 13-35, 40-62, 69-91, 128-150, 157-179, 194-213, 226-245, 249-266, 300-319, 369-391, 412-434, 449-471 and 529-551 522373011230 HMMPfam hit to PF02652, L-lactate permease, score 1.3e-303 522373011231 MgtC family; Region: MgtC; pfam02308 522373011232 HMMPfam hit to PF02308, MgtC family, score 1.6e-17 522373011233 4 probable transmembrane helices predicted for Smlt2911 by TMHMM2.0 at aa 7-25, 35-52, 73-95 and 110-141 522373011234 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 522373011235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373011236 NAD(P) binding site [chemical binding]; other site 522373011237 active site 522373011238 HMMPfam hit to PF00106, short chain dehydrogenase, score 7e-28 522373011239 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 522373011240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373011241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373011242 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.3e-07 522373011243 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 6.6e-06 522373011244 Predicted acyl esterases [General function prediction only]; Region: COG2936 522373011245 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 522373011246 HMMPfam hit to PF08530, X-Pro dipeptidyl-peptidase C-terminal n, score 6e-92 522373011247 HMMPfam hit to PF02129, X-Pro dipeptidyl-peptidase (S15 family), score 2.5e-88 522373011248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 522373011249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373011250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373011251 putative substrate translocation pore; other site 522373011252 13 probable transmembrane helices predicted for Smlt2917 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 101-123, 136-158, 163-182, 195-217, 222-239, 259-281, 291-313, 334-356, 393-412 and 419-438 522373011253 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 8.3e-45 522373011254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373011255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373011256 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373011257 putative effector binding pocket; other site 522373011258 dimerization interface [polypeptide binding]; other site 522373011259 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.2e-20 522373011260 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.8e-38 522373011261 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 522373011262 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 522373011263 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 522373011264 HMMPfam hit to PF01915, Glycosyl hydrolase family 3 C termina, score 6.2e-68 522373011265 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N termina, score 2.4e-93 522373011266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373011267 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 522373011268 active site 522373011269 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 6.9e-05 522373011270 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 522373011271 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 522373011272 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 522373011273 5 probable transmembrane helices predicted for Smlt2922 by TMHMM2.0 at aa 28-50, 57-79, 102-124, 129-151 and 195-217 522373011274 transcriptional regulator; Provisional; Region: PRK10632 522373011275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373011276 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373011277 putative effector binding pocket; other site 522373011278 dimerization interface [polypeptide binding]; other site 522373011279 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.8e-20 522373011280 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.8e-53 522373011281 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 522373011282 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 522373011283 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 1.7e-07 522373011284 Putative cyclase; Region: Cyclase; pfam04199 522373011285 HMMPfam hit to PF04199, Putative cyclase, score 3.5e-06 522373011286 Uncharacterized conserved protein [Function unknown]; Region: COG4544 522373011287 DNA Polymerase Y-family; Region: PolY_like; cd03468 522373011288 active site 522373011289 DNA binding site [nucleotide binding] 522373011290 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 522373011291 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 522373011292 putative active site [active] 522373011293 putative PHP Thumb interface [polypeptide binding]; other site 522373011294 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 522373011295 generic binding surface II; other site 522373011296 generic binding surface I; other site 522373011297 HMMPfam hit to PF02811, PHP domain, score 7.1e-06 522373011298 HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 3.5e-225 522373011299 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 9.5e-09 522373011300 1 probable transmembrane helix predicted for Smlt2929 by TMHMM2.0 at aa 20-42 522373011301 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 522373011302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373011303 DNA-binding site [nucleotide binding]; DNA binding site 522373011304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373011305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373011306 homodimer interface [polypeptide binding]; other site 522373011307 catalytic residue [active] 522373011308 HMMPfam hit to PF00155, Aminotransferase class I and II, score 9.9e-08 522373011309 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fam, score 7.4e-20 522373011310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 522373011311 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 522373011312 catalytic residue [active] 522373011313 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 6e-09 522373011314 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 522373011315 catalytic triad [active] 522373011316 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5.3e-08 522373011317 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 522373011318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373011319 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373011320 DNA binding residues [nucleotide binding] 522373011321 HMMPfam hit to PF04542, Sigma-70 region, score 6.4e-14 522373011322 HMMPfam hit to PF08281, Sigma-70, region, score 4.9e-12 522373011323 HMMPfam hit to PF04545, Sigma-70, region, score 1.1e-09 522373011324 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 522373011325 FecR protein; Region: FecR; pfam04773 522373011326 HMMPfam hit to PF04773, FecR protein, score 2.7e-36 522373011327 Secretin and TonB N terminus short domain; Region: STN; smart00965 522373011328 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 522373011329 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373011330 N-terminal plug; other site 522373011331 ligand-binding site [chemical binding]; other site 522373011332 HMMPfam hit to PF07660, Secretin and TonB N terminus short domai, score 2.2e-05 522373011333 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.7e-08 522373011334 HMMPfam hit to PF00593, TonB dependent receptor, score 1.4e-16 522373011335 Protein of unknown function, DUF399; Region: DUF399; cl01139 522373011336 HMMPfam hit to PF04187, Protein of unknown function, DUF399, score 8.9e-21 522373011337 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 522373011338 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 522373011339 1 probable transmembrane helix predicted for Smlt2939 by TMHMM2.0 at aa 20-42 522373011340 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 522373011341 homotrimer interaction site [polypeptide binding]; other site 522373011342 putative active site [active] 522373011343 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 1.5e-16 522373011344 Cation efflux family; Region: Cation_efflux; cl00316 522373011345 HMMPfam hit to PF01545, Cation efflux family, score 2.2e-12 522373011346 6 probable transmembrane helices predicted for Smlt2941 by TMHMM2.0 at aa 12-34, 44-61, 82-104, 114-133, 150-172 and 182-204 522373011347 arginine decarboxylase; Provisional; Region: PRK15029 522373011348 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 522373011349 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 522373011350 homodimer interface [polypeptide binding]; other site 522373011351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373011352 catalytic residue [active] 522373011353 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 522373011354 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal doma, score 2.6e-64 522373011355 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major domain, score 4.8e-218 522373011356 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal doma, score 1.3e-12 522373011357 arginine:agmatin antiporter; Provisional; Region: PRK10644 522373011358 HMMPfam hit to PF00324, Amino acid permease, score 1.2e-07 522373011359 12 probable transmembrane helices predicted for Smlt2943 by TMHMM2.0 at aa 13-35, 45-64, 98-120, 130-152, 157-179, 199-221, 233-255, 275-297, 326-348, 358-380, 387-409 and 414-433 522373011360 Porin subfamily; Region: Porin_2; pfam02530 522373011361 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 522373011362 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 522373011363 dimer interface [polypeptide binding]; other site 522373011364 catalytic residues [active] 522373011365 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 522373011366 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 522373011367 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373011368 catalytic residues [active] 522373011369 HMMPfam hit to PF08534, Redoxin, score 5.4e-20 522373011370 HMMPfam hit to PF00085, Thioredoxin, score 0.0051 522373011371 3 probable transmembrane helices predicted for Smlt2947 by TMHMM2.0 at aa 7-26, 41-63 and 75-97 522373011372 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 522373011373 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 522373011374 conserved cys residue [active] 522373011375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373011376 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix prote, score 1e-06 522373011377 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix prote, score 0.0003 522373011378 HMMPfam hit to PF01965, DJ-1/PfpI family, score 0.0028 522373011379 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 522373011380 DNA binding residues [nucleotide binding] 522373011381 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 522373011382 dimer interface [polypeptide binding]; other site 522373011383 metal binding site [ion binding]; metal-binding site 522373011384 HMMPfam hit to PF00376, MerR family regulatory protein, score 3.9e-11 522373011385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373011386 Coenzyme A binding pocket [chemical binding]; other site 522373011387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 522373011388 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1e-11 522373011389 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 522373011390 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373011391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373011392 active site 522373011393 phosphorylation site [posttranslational modification] 522373011394 dimerization interface [polypeptide binding]; other site 522373011395 HMMPfam hit to PF00072, Response regulator receiver domain, score 0.00061 522373011396 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373011397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373011398 metal binding site [ion binding]; metal-binding site 522373011399 active site 522373011400 I-site; other site 522373011401 10 probable transmembrane helices predicted for Smlt2953 by TMHMM2.0 at aa 7-24, 29-48, 60-79, 89-111, 118-138, 148-170, 183-201, 216-233, 246-268 and 273-292 522373011402 HMMPfam hit to PF00990, GGDEF domain, score 3.4e-65 522373011403 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 522373011404 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373011405 putative active site [active] 522373011406 heme pocket [chemical binding]; other site 522373011407 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373011408 putative active site [active] 522373011409 heme pocket [chemical binding]; other site 522373011410 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373011411 dimer interface [polypeptide binding]; other site 522373011412 putative CheW interface [polypeptide binding]; other site 522373011413 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 4.5e-86 522373011414 HMMPfam hit to PF08448, PAS fold, score 5.5e-07 522373011415 HMMPfam hit to PF08447, PAS fold, score 1.8e-20 522373011416 HMMPfam hit to PF00989, PAS fold, score 0.0075 522373011417 HMMPfam hit to PF08448, PAS fold, score 2.9e-11 522373011418 HMMPfam hit to PF08447, PAS fold, score 5.9e-21 522373011419 HMMPfam hit to PF00989, PAS fold, score 0.0065 522373011420 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 522373011421 Uncharacterized conserved protein [Function unknown]; Region: COG1359 522373011422 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 2.9e-17 522373011423 2 probable transmembrane helices predicted for Smlt2958 by TMHMM2.0 at aa 7-29 and 44-66 522373011424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373011425 PAS fold; Region: PAS_3; pfam08447 522373011426 putative active site [active] 522373011427 heme pocket [chemical binding]; other site 522373011428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373011429 PAS domain; Region: PAS_9; pfam13426 522373011430 putative active site [active] 522373011431 heme pocket [chemical binding]; other site 522373011432 PAS domain S-box; Region: sensory_box; TIGR00229 522373011433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373011434 putative active site [active] 522373011435 heme pocket [chemical binding]; other site 522373011436 PAS fold; Region: PAS_4; pfam08448 522373011437 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 522373011438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373011439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373011440 metal binding site [ion binding]; metal-binding site 522373011441 active site 522373011442 I-site; other site 522373011443 HMMPfam hit to PF00990, GGDEF domain, score 5.8e-57 522373011444 HMMPfam hit to PF08448, PAS fold, score 0.00023 522373011445 HMMPfam hit to PF00989, PAS fold, score 0.16 522373011446 HMMPfam hit to PF08448, PAS fold, score 9.5e-07 522373011447 HMMPfam hit to PF08447, PAS fold, score 7.2e-22 522373011448 HMMPfam hit to PF00989, PAS fold, score 7.8e-15 522373011449 HMMPfam hit to PF08448, PAS fold, score 3.5e-05 522373011450 HMMPfam hit to PF08447, PAS fold, score 0.002 522373011451 HMMPfam hit to PF00989, PAS fold, score 8.7e-12 522373011452 HMMPfam hit to PF08447, PAS fold, score 8.3e-27 522373011453 HMMPfam hit to PF00989, PAS fold, score 0.13 522373011454 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 522373011455 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 522373011456 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 522373011457 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 522373011458 RNA binding site [nucleotide binding]; other site 522373011459 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.5e-25 522373011460 hypothetical protein; Provisional; Region: PRK10318 522373011461 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 522373011462 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 2.4e-12 522373011463 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; pfam09712 522373011464 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 522373011465 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 522373011466 4 probable transmembrane helices predicted for Smlt2966 by TMHMM2.0 at aa 13-32, 42-60, 137-159 and 174-196 522373011467 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 3.1e-27 522373011468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373011469 S-adenosylmethionine binding site [chemical binding]; other site 522373011470 HMMPfam hit to PF08241, Methyltransferase domain, score 3.5e-26 522373011471 HMMPfam hit to PF08242, Methyltransferase domain, score 6.9e-13 522373011472 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 522373011473 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 522373011474 11 probable transmembrane helices predicted for Smlt2970 by TMHMM2.0 at aa 71-93, 114-136, 156-178, 191-213, 217-236, 270-292, 312-334, 347-369, 384-406, 413-435 and 445-467 522373011475 HMMPfam hit to PF01554, MatE, score 4.1e-22 522373011476 HMMPfam hit to PF01554, MatE, score 1.8e-30 522373011477 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 522373011478 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 522373011479 putative active site [active] 522373011480 nucleotide binding site [chemical binding]; other site 522373011481 nudix motif; other site 522373011482 putative metal binding site [ion binding]; other site 522373011483 HMMPfam hit to PF00293, NUDIX domain, score 1.5e-19 522373011484 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 522373011485 HMMPfam hit to PF06853, Protein of unknown function (DUF1249), score 3.8e-65 522373011486 PEP synthetase regulatory protein; Provisional; Region: PRK05339 522373011487 HMMPfam hit to PF03618, Domain of unknown function (DUF299), score 1.5e-144 522373011488 phosphoenolpyruvate synthase; Validated; Region: PRK06464 522373011489 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 522373011490 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 522373011491 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 522373011492 HMMPfam hit to PF01326, Pyruvate phosphate dikinase, PEP/pyru, score 4.9e-108 522373011493 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 2e-41 522373011494 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 2.3e-61 522373011495 Mechanosensitive ion channel; Region: MS_channel; pfam00924 522373011496 2 probable transmembrane helices predicted for Smlt2977 by TMHMM2.0 at aa 4-22 and 43-65 522373011497 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 3.3e-62 522373011498 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 522373011499 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 522373011500 FMN binding site [chemical binding]; other site 522373011501 active site 522373011502 substrate binding site [chemical binding]; other site 522373011503 catalytic residue [active] 522373011504 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 1.3e-91 522373011505 EcsC protein family; Region: EcsC; pfam12787 522373011506 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 522373011507 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 522373011508 catalytic site [active] 522373011509 putative active site [active] 522373011510 putative substrate binding site [chemical binding]; other site 522373011511 dimer interface [polypeptide binding]; other site 522373011512 HMMPfam hit to PF00929, Exonuclease, score 3.2e-22 522373011513 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 522373011514 nucleoside/Zn binding site; other site 522373011515 dimer interface [polypeptide binding]; other site 522373011516 catalytic motif [active] 522373011517 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 2.8e-37 522373011518 Predicted transcriptional regulators [Transcription]; Region: COG1733 522373011519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373011520 dimerization interface [polypeptide binding]; other site 522373011521 putative DNA binding site [nucleotide binding]; other site 522373011522 putative Zn2+ binding site [ion binding]; other site 522373011523 HMMPfam hit to PF01638, HxlR-like helix-turn-helix, score 7.4e-26 522373011524 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 522373011525 HMMPfam hit to PF02525, Flavodoxin-like fold, score 4.7e-43 522373011526 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 0.00052 522373011527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 522373011528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373011529 Coenzyme A binding pocket [chemical binding]; other site 522373011530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 522373011531 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4.4e-15 522373011532 1 probable transmembrane helix predicted for Smlt2986 by TMHMM2.0 at aa 19-41 522373011533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 522373011534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373011535 Coenzyme A binding pocket [chemical binding]; other site 522373011536 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.2e-15 522373011537 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 522373011538 nucleophilic elbow; other site 522373011539 catalytic triad; other site 522373011540 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 522373011541 catalytic residue [active] 522373011542 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 522373011543 1 probable transmembrane helix predicted for Smlt2994 by TMHMM2.0 at aa 42-61 522373011544 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 522373011545 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 522373011546 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 522373011547 5 probable transmembrane helices predicted for Smlt2997 by TMHMM2.0 at aa 54-76, 89-111, 191-213, 225-247 and 283-305 522373011548 1 probable transmembrane helix predicted for Smlt2998 by TMHMM2.0 at aa 28-50 522373011549 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 522373011550 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 522373011551 HMMPfam hit to PF03135, CagE, TrbE, VirB family, component of, score 3.7e-66 522373011552 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 522373011553 HMMPfam hit to PF05101, Type IV secretory pathway, VirB3-like protei, score 2.9e-15 522373011554 2 probable transmembrane helices predicted for Smlt3000 by TMHMM2.0 at aa 13-35 and 40-57 522373011555 3 probable transmembrane helices predicted for Smlt3001 by TMHMM2.0 at aa 61-83, 98-120 and 127-149 522373011556 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 522373011557 N-acetyl-D-glucosamine binding site [chemical binding]; other site 522373011558 catalytic residue [active] 522373011559 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 0.00043 522373011560 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 522373011561 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 522373011562 Walker A motif; other site 522373011563 hexamer interface [polypeptide binding]; other site 522373011564 ATP binding site [chemical binding]; other site 522373011565 Walker B motif; other site 522373011566 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 1.6e-59 522373011567 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 522373011568 HMMPfam hit to PF03743, Bacterial conjugation TrbI-like protein, score 1.8e-54 522373011569 1 probable transmembrane helix predicted for Smlt3004 by TMHMM2.0 at aa 61-80 522373011570 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 522373011571 VirB7 interaction site; other site 522373011572 HMMPfam hit to PF03524, Conjugal transfer protein, score 1.6e-29 522373011573 VirB8 protein; Region: VirB8; pfam04335 522373011574 HMMPfam hit to PF04335, VirB8 protein, score 1.1e-30 522373011575 1 probable transmembrane helix predicted for Smlt3006 by TMHMM2.0 at aa 38-60 522373011576 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 522373011577 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 522373011578 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 522373011579 Walker A motif; other site 522373011580 ATP binding site [chemical binding]; other site 522373011581 Walker B motif; other site 522373011582 HMMPfam hit to PF02534, TraG/TraD family, score 1.9e-105 522373011583 2 probable transmembrane helices predicted for Smlt3008 by TMHMM2.0 at aa 7-29 and 66-88 522373011584 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 522373011585 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 522373011586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373011587 putative substrate translocation pore; other site 522373011588 12 probable transmembrane helices predicted for Smlt3011 by TMHMM2.0 at aa 19-41, 56-78, 85-107, 112-134, 147-169, 173-195, 216-238, 253-274, 281-300, 304-323, 343-365 and 369-391 522373011589 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.2e-43 522373011590 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 522373011591 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 522373011592 DNA binding residues [nucleotide binding] 522373011593 HMMPfam hit to PF00376, MerR family regulatory protein, score 5.2e-09 522373011594 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 522373011595 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 522373011596 putative active site [active] 522373011597 putative FMN binding site [chemical binding]; other site 522373011598 putative substrate binding site [chemical binding]; other site 522373011599 putative catalytic residue [active] 522373011600 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 7.4e-55 522373011601 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 522373011602 3 probable transmembrane helices predicted for Smlt3014 by TMHMM2.0 at aa 39-58, 73-95 and 108-130 522373011603 4 probable transmembrane helices predicted for Smlt3015 by TMHMM2.0 at aa 30-49, 54-76, 168-190 and 194-211 522373011604 3 probable transmembrane helices predicted for Smlt3016 by TMHMM2.0 at aa 29-51, 56-78 and 88-105 522373011605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373011606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373011607 dimer interface [polypeptide binding]; other site 522373011608 phosphorylation site [posttranslational modification] 522373011609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373011610 ATP binding site [chemical binding]; other site 522373011611 Mg2+ binding site [ion binding]; other site 522373011612 G-X-G motif; other site 522373011613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373011614 Response regulator receiver domain; Region: Response_reg; pfam00072 522373011615 active site 522373011616 phosphorylation site [posttranslational modification] 522373011617 intermolecular recognition site; other site 522373011618 dimerization interface [polypeptide binding]; other site 522373011619 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.1e-10 522373011620 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 3.4e-30 522373011621 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.3e-16 522373011622 hypothetical protein; Provisional; Region: PRK06834 522373011623 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 522373011624 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 522373011625 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0004 522373011626 HMMPfam hit to PF01494, FAD binding domain, score 1.6e-59 522373011627 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373011628 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373011629 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 3e-15 522373011630 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 522373011631 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373011632 N-terminal plug; other site 522373011633 ligand-binding site [chemical binding]; other site 522373011634 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.5e-19 522373011635 HMMPfam hit to PF00593, TonB dependent receptor, score 2.9e-21 522373011636 Predicted transcriptional regulators [Transcription]; Region: COG1733 522373011637 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 522373011638 HMMPfam hit to PF01638, HxlR-like helix-turn-helix, score 4.1e-44 522373011639 1 probable transmembrane helix predicted for Smlt3026 by TMHMM2.0 at aa 13-35 522373011640 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 522373011641 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 522373011642 NADP binding site [chemical binding]; other site 522373011643 dimer interface [polypeptide binding]; other site 522373011644 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 5.9e-09 522373011645 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 2.5e-17 522373011646 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373011647 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 522373011648 HMMPfam hit to PF00023, Ankyrin repeat, score 0.0043 522373011649 HMMPfam hit to PF00023, Ankyrin repeat, score 0.0022 522373011650 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 522373011651 Part of AAA domain; Region: AAA_19; pfam13245 522373011652 Family description; Region: UvrD_C_2; pfam13538 522373011653 HMMPfam hit to PF00580, UvrD/REP helicase, score 1.9e-09 522373011654 HMMPfam hit to PF01396, no description, score 0.033 522373011655 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 522373011656 DNA binding site [nucleotide binding] 522373011657 active site 522373011658 Int/Topo IB signature motif; other site 522373011659 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 522373011660 AAA domain; Region: AAA_12; pfam13087 522373011661 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 522373011662 putative active site [active] 522373011663 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 522373011664 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373011665 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373011666 HMMPfam hit to PF00023, Ankyrin repeat, score 0.0017 522373011667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373011668 AAA domain; Region: AAA_21; pfam13304 522373011669 Walker A/P-loop; other site 522373011670 ATP binding site [chemical binding]; other site 522373011671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 522373011672 Q-loop/lid; other site 522373011673 ABC transporter signature motif; other site 522373011674 Walker B; other site 522373011675 D-loop; other site 522373011676 H-loop/switch region; other site 522373011677 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 522373011678 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 522373011679 active site 522373011680 DNA binding site [nucleotide binding] 522373011681 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 522373011682 HMMPfam hit to PF00817, impB/mucB/samB family, score 1.6e-88 522373011683 Transposase; Region: HTH_Tnp_1; pfam01527 522373011684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373011685 HMMPfam hit to PF01527, Transposase, score 1.4e-19 522373011686 putative transposase OrfB; Reviewed; Region: PHA02517 522373011687 HTH-like domain; Region: HTH_21; pfam13276 522373011688 Integrase core domain; Region: rve; pfam00665 522373011689 Integrase core domain; Region: rve_2; pfam13333 522373011690 HMMPfam hit to PF00665, Integrase core domain, score 7.9e-27 522373011691 putative integrase, pseudogene;Similar to N-terminus to codon 110 of Xanthomonas campestris pv. vesicatoria (strain 85-10). phage-related integrase. UniProt:Q3BUY5 (EMBL:AM039952 (453 aa) fasta scores: E()=1e-18, 58.095% id in 105 aa; similarity:fasta; with=UniProt:Q3BUY5 (EMBL:AM039952;); Xanthomonas campestris pv. vesicatoria (strain 85-10).; Phage-related integrase.; length=453; id 58.095%; ungapped id 58.095%; E()=1e-18; 105 aa overlap; query 1-105; subject 1-105 522373011692 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 522373011693 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 522373011694 HMMPfam hit to PF02557, D-alanyl-D-alanine carboxypeptidase, score 4.2e-05 522373011695 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 522373011696 trimer interface [polypeptide binding]; other site 522373011697 HMMPfam hit to PF05658, Hep_Hag, score 0.22 522373011698 HMMPfam hit to PF05658, Hep_Hag, score 0.0017 522373011699 HMMPfam hit to PF05658, Hep_Hag, score 0.00015 522373011700 HMMPfam hit to PF05658, Hep_Hag, score 0.0036 522373011701 HMMPfam hit to PF05658, Hep_Hag, score 0.03 522373011702 HMMPfam hit to PF05658, Hep_Hag, score 0.061 522373011703 HMMPfam hit to PF05658, Hep_Hag, score 0.0023 522373011704 HMMPfam hit to PF05658, Hep_Hag, score 0.06 522373011705 HMMPfam hit to PF05662, Haemagglutinin, score 2.3e-05 522373011706 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 522373011707 GIY-YIG motif/motif A; other site 522373011708 active site 522373011709 catalytic site [active] 522373011710 metal binding site [ion binding]; metal-binding site 522373011711 TrwC relaxase; Region: TrwC; pfam08751 522373011712 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 522373011713 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 522373011714 AAA domain; Region: AAA_30; pfam13604 522373011715 HIRAN domain; Region: HIRAN; cl07418 522373011716 AAA-like domain; Region: AAA_10; pfam12846 522373011717 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 522373011718 Walker A motif; other site 522373011719 ATP binding site [chemical binding]; other site 522373011720 Walker B motif; other site 522373011721 1 probable transmembrane helix predicted for Smlt3053 by TMHMM2.0 at aa 29-51 522373011722 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373011723 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373011724 HMMPfam hit to PF00023, Ankyrin repeat, score 0.0001 522373011725 HMMPfam hit to PF00023, Ankyrin repeat, score 2.2e-08 522373011726 2 probable transmembrane helices predicted for Smlt3056 by TMHMM2.0 at aa 13-35 and 40-62 522373011727 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 522373011728 4 probable transmembrane helices predicted for Smlt3058 by TMHMM2.0 at aa 149-171, 191-208, 231-253 and 273-295 522373011729 1 probable transmembrane helix predicted for Smlt3059 by TMHMM2.0 at aa 86-108 522373011730 1 probable transmembrane helix predicted for Smlt3060 by TMHMM2.0 at aa 237-259 522373011731 HNH endonuclease; Region: HNH_2; pfam13391 522373011732 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 522373011733 ParA-like protein; Provisional; Region: PHA02518 522373011734 P-loop; other site 522373011735 Magnesium ion binding site [ion binding]; other site 522373011736 PilS N terminal; Region: PilS; pfam08805 522373011737 HMMPfam hit to PF08805, PilS, score 1.5e-07 522373011738 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373011739 4 probable transmembrane helices predicted for Smlt3081 by TMHMM2.0 at aa 12-34, 49-71, 96-118 and 133-155 522373011740 putative transposase OrfB; Reviewed; Region: PHA02517 522373011741 HTH-like domain; Region: HTH_21; pfam13276 522373011742 Integrase core domain; Region: rve; pfam00665 522373011743 Integrase core domain; Region: rve_2; pfam13333 522373011744 HMMPfam hit to PF00665, Integrase core domain, score 3.3e-32 522373011745 putative transposase, pseudogene;Similar to Xanthomonas campestris pv. vesicatoria (strain 85-10) isxac3 transposase. UniProt:Q3BYS7 (95 aa) fasta scores: E()=2.5e-28, 90.426% id in 94 aa; similarity:fasta; with=UniProt:Q3BYS7; Xanthomonas campestris pv. vesicatoria (strain 85-10).; ISxac3 transposase.; length=95; id 90.426%; ungapped id 91.398%; E()=2.5e-28; 94 aa overlap; query 1-93; subject 1-94 522373011746 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 522373011747 Int/Topo IB signature motif; other site 522373011748 conserved hypothetical protein, pseudogene;similarity:fasta; with=UniProt:Q2K3F4; Rhizobium etli (strain CFN 42/ATCC 51251).; Hypothetical conserved protein.; length=249; id 30.690%; ungapped id 39.207%; E()=0.0019; 290 aa overlap; query 75-360; subject 18-248 522373011749 LysR family transcriptional regulator; Provisional; Region: PRK14997 522373011750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373011751 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 522373011752 putative effector binding pocket; other site 522373011753 putative dimerization interface [polypeptide binding]; other site 522373011754 HMMPfam hit to PF03466, LysR substrate binding domain, score 7.7e-42 522373011755 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-13 522373011756 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 522373011757 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373011758 HMMPfam hit to PF02525, Flavodoxin-like fold, score 1.2e-44 522373011759 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 3.2e-05 522373011760 Src Homology 3 domain superfamily; Region: SH3; cl17036 522373011761 peptide ligand binding site [polypeptide binding]; other site 522373011762 HMMPfam hit to PF07653, Variant SH3 domain, score 0.081 522373011763 HMMPfam hit to PF07653, Variant SH3 domain, score 0.0086 522373011764 seryl-tRNA synthetase; Provisional; Region: PRK05431 522373011765 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 522373011766 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 522373011767 dimer interface [polypeptide binding]; other site 522373011768 active site 522373011769 motif 1; other site 522373011770 motif 2; other site 522373011771 motif 3; other site 522373011772 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 4.4e-61 522373011773 HMMPfam hit to PF02403, Seryl-tRNA synthetase N-terminal domain, score 8.6e-40 522373011774 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 522373011775 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373011776 1 probable transmembrane helix predicted for Smlt3093 by TMHMM2.0 at aa 56-78 522373011777 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 6e-11 522373011778 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 522373011779 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373011780 1 probable transmembrane helix predicted for Smlt3094 by TMHMM2.0 at aa 28-45 522373011781 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 7.8e-08 522373011782 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 522373011783 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 522373011784 hinge; other site 522373011785 active site 522373011786 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 1.1e-136 522373011787 Chorismate mutase type II; Region: CM_2; pfam01817 522373011788 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 522373011789 Prephenate dehydratase; Region: PDT; pfam00800 522373011790 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 522373011791 putative L-Phe binding site [chemical binding]; other site 522373011792 HMMPfam hit to PF01842, ACT domain, score 8.8e-14 522373011793 HMMPfam hit to PF00800, Prephenate dehydratase, score 3.4e-71 522373011794 HMMPfam hit to PF01817, Chorismate mutase type II, score 1.4e-30 522373011795 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 522373011796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373011797 catalytic residue [active] 522373011798 HMMPfam hit to PF00266, Aminotransferase class-V, score 1.2e-39 522373011799 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 522373011800 FHA domain; Region: FHA; pfam00498 522373011801 1 probable transmembrane helix predicted for Smlt3099 by TMHMM2.0 at aa 245-267 522373011802 HMMPfam hit to PF00498, FHA domain, score 5.3e-11 522373011803 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 522373011804 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 522373011805 HMMPfam hit to PF05597, Poly(hydroxyalcanoate) granule associated pr, score 8.1e-42 522373011806 2 probable transmembrane helices predicted for Smlt3103 by TMHMM2.0 at aa 20-42 and 190-212 522373011807 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 522373011808 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 522373011809 HMMPfam hit to PF03681, Uncharacterised protein family (UPF0150), score 6.7e-18 522373011810 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 522373011811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373011812 DNA-binding site [nucleotide binding]; DNA binding site 522373011813 UTRA domain; Region: UTRA; pfam07702 522373011814 HMMPfam hit to PF07702, UTRA domain, score 1.9e-33 522373011815 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 6e-18 522373011816 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 522373011817 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 522373011818 active site 522373011819 HMMPfam hit to PF01979, Amidohydrolase family, score 1.1e-07 522373011820 imidazolonepropionase; Validated; Region: PRK09356 522373011821 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 522373011822 active site 522373011823 HMMPfam hit to PF01979, Amidohydrolase family, score 4e-06 522373011824 HMMPfam hit to PF07969, Amidohydrolase family, score 1.2e-07 522373011825 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 522373011826 active sites [active] 522373011827 tetramer interface [polypeptide binding]; other site 522373011828 HMMPfam hit to PF00221, Phenylalanine and histidine ammonia-lyase, score 1.4e-202 522373011829 N-formylglutamate amidohydrolase; Region: FGase; cl01522 522373011830 HMMPfam hit to PF05013, N-formylglutamate amidohydrolase, score 7.1e-90 522373011831 urocanate hydratase; Provisional; Region: PRK05414 522373011832 HMMPfam hit to PF01175, Urocanase, score 0 522373011833 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373011834 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373011835 HMMPfam hit to PF00144, Beta-lactamase, score 4.1e-47 522373011836 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373011837 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 522373011838 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.1e-14 522373011839 HMMPfam hit to PF00593, TonB dependent receptor, score 5.4e-21 522373011840 3 probable transmembrane helices predicted for Smlt3116 by TMHMM2.0 at aa 12-34, 65-87 and 99-121 522373011841 1 probable transmembrane helix predicted for Smlt3117 by TMHMM2.0 at aa 17-39 522373011842 1 probable transmembrane helix predicted for Smlt3118 by TMHMM2.0 at aa 12-29 522373011843 1 probable transmembrane helix predicted for Smlt3119 by TMHMM2.0 at aa 41-63 522373011844 SnoaL-like domain; Region: SnoaL_2; pfam12680 522373011845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373011846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373011847 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.2e-09 522373011848 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 522373011849 active site 522373011850 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 522373011851 active site 522373011852 catalytic triad [active] 522373011853 oxyanion hole [active] 522373011854 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 1.9e-23 522373011855 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 522373011856 1 probable transmembrane helix predicted for Smlt3124 by TMHMM2.0 at aa 46-68 522373011857 2 probable transmembrane helices predicted for Smlt3125 by TMHMM2.0 at aa 113-132 and 136-158 522373011858 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 522373011859 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 522373011860 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373011861 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 8.4e-10 522373011862 1 probable transmembrane helix predicted for Smlt3128 by TMHMM2.0 at aa 21-43 522373011863 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 522373011864 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373011865 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373011866 HMMPfam hit to PF00144, Beta-lactamase, score 2.4e-79 522373011867 1 probable transmembrane helix predicted for Smlt3132 by TMHMM2.0 at aa 7-29 522373011868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373011869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373011870 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 522373011871 putative effector binding pocket; other site 522373011872 putative dimerization interface [polypeptide binding]; other site 522373011873 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.5e-53 522373011874 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.3e-17 522373011875 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 522373011876 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 522373011877 putative NAD(P) binding site [chemical binding]; other site 522373011878 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 5.9e-20 522373011879 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 4.9e-29 522373011880 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 522373011881 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 522373011882 Trp docking motif [polypeptide binding]; other site 522373011883 putative active site [active] 522373011884 HMMPfam hit to PF01011, PQQ enzyme repeat, score 2.1e-06 522373011885 HMMPfam hit to PF01011, PQQ enzyme repeat, score 2.4e-09 522373011886 5 probable transmembrane helices predicted for Smlt3136 by TMHMM2.0 at aa 20-42, 47-66, 71-88, 98-117 and 130-149 522373011887 DNA gyrase subunit A; Validated; Region: PRK05560 522373011888 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 522373011889 CAP-like domain; other site 522373011890 active site 522373011891 primary dimer interface [polypeptide binding]; other site 522373011892 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 522373011893 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 522373011894 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 522373011895 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 522373011896 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 522373011897 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.6e-12 522373011898 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.7e-14 522373011899 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 4.4e-13 522373011900 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 7e-12 522373011901 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 4.2e-15 522373011902 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 5.1e-13 522373011903 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 0 522373011904 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 522373011905 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 522373011906 HMMPfam hit to PF01008, Initiation factor 2 subunit family, score 2.2e-104 522373011907 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 522373011908 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 522373011909 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 522373011910 motif 1; other site 522373011911 dimer interface [polypeptide binding]; other site 522373011912 active site 522373011913 motif 2; other site 522373011914 motif 3; other site 522373011915 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 3.3e-61 522373011916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 522373011917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373011918 Coenzyme A binding pocket [chemical binding]; other site 522373011919 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.2e-11 522373011920 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 522373011921 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 522373011922 nucleotide binding pocket [chemical binding]; other site 522373011923 K-X-D-G motif; other site 522373011924 catalytic site [active] 522373011925 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 522373011926 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 522373011927 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 522373011928 Dimer interface [polypeptide binding]; other site 522373011929 BRCT sequence motif; other site 522373011930 HMMPfam hit to PF00533, BRCA1 C Terminus (BRCT) domain, score 8.6e-17 522373011931 HMMPfam hit to PF03119, NAD-dependent DNA ligase C4 zinc fing, score 1.2e-11 522373011932 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 5.1e-43 522373011933 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 4.6e-170 522373011934 putative aminotransferase; Provisional; Region: PRK09105 522373011935 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373011936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373011937 homodimer interface [polypeptide binding]; other site 522373011938 catalytic residue [active] 522373011939 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.8e-30 522373011940 cell division protein ZipA; Provisional; Region: PRK04570 522373011941 FtsZ protein binding site [polypeptide binding]; other site 522373011942 HMMPfam hit to PF04354, ZipA, C-terminal FtsZ-binding domain, score 1.4e-75 522373011943 1 probable transmembrane helix predicted for Smlt3144 by TMHMM2.0 at aa 4-26 522373011944 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 522373011945 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 522373011946 Walker A/P-loop; other site 522373011947 ATP binding site [chemical binding]; other site 522373011948 Q-loop/lid; other site 522373011949 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 522373011950 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 522373011951 ABC transporter signature motif; other site 522373011952 Walker B; other site 522373011953 D-loop; other site 522373011954 H-loop/switch region; other site 522373011955 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 9.7e-109 522373011956 HMMPfam hit to PF06470, SMC proteins Flexible Hinge Domain, score 3.5e-17 522373011957 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 522373011958 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 522373011959 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 522373011960 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 522373011961 HMMPfam hit to PF03948, Ribosomal protein L9, C-terminal domai, score 1.7e-22 522373011962 HMMPfam hit to PF01281, Ribosomal protein L9, N-terminal domai, score 2.9e-24 522373011963 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 522373011964 HMMPfam hit to PF01084, Ribosomal protein S18, score 1.6e-29 522373011965 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 522373011966 HMMPfam hit to PF01250, Ribosomal protein S6, score 1.2e-20 522373011967 Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691 522373011968 HMMPfam hit to PF03691, Uncharacterised protein family (UPF0167), score 9.4e-38 522373011969 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 522373011970 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 1.3e-23 522373011971 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 522373011972 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 522373011973 putative anticodon binding site; other site 522373011974 putative dimer interface [polypeptide binding]; other site 522373011975 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 522373011976 homodimer interface [polypeptide binding]; other site 522373011977 motif 1; other site 522373011978 motif 2; other site 522373011979 active site 522373011980 motif 3; other site 522373011981 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 5.1e-07 522373011982 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 1.9e-73 522373011983 2 probable transmembrane helices predicted for Smlt3155 by TMHMM2.0 at aa 7-29 and 76-98 522373011984 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 522373011985 HMMPfam hit to PF04299, Putative FMN-binding domain, score 1.6e-26 522373011986 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 522373011987 active site clefts [active] 522373011988 zinc binding site [ion binding]; other site 522373011989 dimer interface [polypeptide binding]; other site 522373011990 HMMPfam hit to PF00484, Carbonic anhydrase, score 5.1e-47 522373011991 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 522373011992 HMMPfam hit to PF06052, 3-hydroxyanthranilic acid dioxygenase, score 2.4e-68 522373011993 HMMPfam hit to PF07883, Cupin domain, score 0.0037 522373011994 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 522373011995 kynureninase; Region: kynureninase; TIGR01814 522373011996 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373011997 catalytic residue [active] 522373011998 HMMPfam hit to PF00266, Aminotransferase class-V, score 6.3e-05 522373011999 FAD binding domain; Region: FAD_binding_3; pfam01494 522373012000 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 522373012001 HMMPfam hit to PF01494, FAD binding domain, score 3.3e-09 522373012002 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00055 522373012003 exonuclease I; Provisional; Region: sbcB; PRK11779 522373012004 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 522373012005 active site 522373012006 catalytic site [active] 522373012007 substrate binding site [chemical binding]; other site 522373012008 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 522373012009 HMMPfam hit to PF00929, Exonuclease, score 7e-22 522373012010 HMMPfam hit to PF08411, Exonuclease C-terminal, score 3.6e-125 522373012011 TIGR02453 family protein; Region: TIGR02453 522373012012 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 522373012013 1 probable transmembrane helix predicted for Smlt3164 by TMHMM2.0 at aa 5-27 522373012014 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 522373012015 HMMPfam hit to PF06189, 5'-nucleotidase, score 6.2e-141 522373012016 ATP-NAD kinase; Region: NAD_kinase; pfam01513 522373012017 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 522373012018 Glutamate dehydrogenase N terminal; Region: GDH_N; pfam12466 522373012019 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 522373012020 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 522373012021 HMMPfam hit to PF05088, Bacterial NAD-glutamate dehydrogenase, score 0 522373012022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373012023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373012024 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 522373012025 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2.5e-09 522373012026 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373012027 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373012028 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373012029 HMMPfam hit to PF00529, HlyD family secretion protein, score 5.8e-49 522373012030 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 522373012031 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373012032 11 probable transmembrane helices predicted for Smlt3171 by TMHMM2.0 at aa 10-32, 340-362, 366-388, 438-460, 470-492, 537-559, 869-891, 898-920, 925-947, 968-990 and 1005-1027 522373012033 3 probable transmembrane helices predicted for Smlt3172 by TMHMM2.0 at aa 44-66, 78-100 and 115-137 522373012034 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 522373012035 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 522373012036 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 522373012037 active site 522373012038 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 3.1e-65 522373012039 HMMPfam hit to PF08028, Acyl-CoA dehydrogenase, C-terminal doma, score 5e-29 522373012040 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 2e-22 522373012041 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 2.9e-37 522373012042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 522373012043 dimerization interface [polypeptide binding]; other site 522373012044 putative DNA binding site [nucleotide binding]; other site 522373012045 putative Zn2+ binding site [ion binding]; other site 522373012046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373012047 Methyltransferase domain; Region: Methyltransf_31; pfam13847 522373012048 S-adenosylmethionine binding site [chemical binding]; other site 522373012049 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR fa, score 2.4e-15 522373012050 HMMPfam hit to PF05401, Nodulation protein S (NodS), score 0.00057 522373012051 HMMPfam hit to PF08241, Methyltransferase domain, score 2.1e-28 522373012052 HMMPfam hit to PF08242, Methyltransferase domain, score 5.3e-16 522373012053 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 522373012054 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 522373012055 HMMPfam hit to PF02574, Homocysteine S-methyltransferase, score 4.9e-145 522373012056 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 522373012057 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 522373012058 substrate binding pocket [chemical binding]; other site 522373012059 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 522373012060 B12 binding site [chemical binding]; other site 522373012061 cobalt ligand [ion binding]; other site 522373012062 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 522373012063 HMMPfam hit to PF00809, Pterin binding enzyme, score 1.2e-66 522373012064 HMMPfam hit to PF02607, B12 binding domain, score 3e-42 522373012065 HMMPfam hit to PF02310, B12 binding domain, score 2.7e-26 522373012066 HMMPfam hit to PF02965, Vitamin B12 dependent methionine syntha, score 1.7e-62 522373012067 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 522373012068 MFS_1 like family; Region: MFS_1_like; pfam12832 522373012069 12 probable transmembrane helices predicted for Smlt3178 by TMHMM2.0 at aa 21-43, 53-75, 82-103, 107-129, 141-163, 173-195, 216-238, 253-275, 282-299, 309-331, 344-366 and 376-398 522373012070 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.7e-07 522373012071 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 522373012072 hypothetical protein; Provisional; Region: PRK00846 522373012073 HMMPfam hit to PF04102, SlyX, score 1.9e-24 522373012074 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 522373012075 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 522373012076 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 522373012077 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 522373012078 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 2.8e-36 522373012079 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 1.6e-54 522373012080 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 3.7e-103 522373012081 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 522373012082 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 522373012083 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 522373012084 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 522373012085 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 1.6e-40 522373012086 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 1.1e-12 522373012087 1 probable transmembrane helix predicted for Smlt3182 by TMHMM2.0 at aa 36-58 522373012088 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 522373012089 catalytic residues [active] 522373012090 dimer interface [polypeptide binding]; other site 522373012091 HMMPfam hit to PF00255, Glutathione peroxidase, score 7.6e-39 522373012092 1 probable transmembrane helix predicted for Smlt3183 by TMHMM2.0 at aa 20-42 522373012093 1 probable transmembrane helix predicted for Smlt3184 by TMHMM2.0 at aa 43-65 522373012094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373012095 DNA-binding site [nucleotide binding]; DNA binding site 522373012096 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.2e-12 522373012097 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 522373012098 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 522373012099 Walker A/P-loop; other site 522373012100 ATP binding site [chemical binding]; other site 522373012101 Q-loop/lid; other site 522373012102 ABC transporter signature motif; other site 522373012103 Walker B; other site 522373012104 D-loop; other site 522373012105 H-loop/switch region; other site 522373012106 HMMPfam hit to PF00005, ABC transporter score 3.7e-33 522373012107 6 probable transmembrane helices predicted for Smlt3187 by TMHMM2.0 at aa 28-50, 99-121, 160-182, 208-230, 235-257 and 313-335 522373012108 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 522373012109 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 522373012110 1 probable transmembrane helix predicted for Smlt3190 by TMHMM2.0 at aa 15-29 522373012111 fumarate hydratase; Reviewed; Region: fumC; PRK00485 522373012112 Class II fumarases; Region: Fumarase_classII; cd01362 522373012113 active site 522373012114 tetramer interface [polypeptide binding]; other site 522373012115 HMMPfam hit to PF00206, Lyase, score 2.8e-131 522373012116 adenylosuccinate lyase; Provisional; Region: PRK09285 522373012117 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 522373012118 tetramer interface [polypeptide binding]; other site 522373012119 active site 522373012120 HMMPfam hit to PF00206, Lyase, score 2.1e-66 522373012121 HMMPfam hit to PF08328, Adenylosuccinate lyase C-terminal, score 1.5e-83 522373012122 Uncharacterized conserved protein [Function unknown]; Region: COG2850 522373012123 HMMPfam hit to PF08007, Cupin superfamily protein, score 2.5e-133 522373012124 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 522373012125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 522373012126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373012127 Coenzyme A binding pocket [chemical binding]; other site 522373012128 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.8e-15 522373012129 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 522373012130 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 522373012131 TPP-binding site [chemical binding]; other site 522373012132 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 522373012133 dimer interface [polypeptide binding]; other site 522373012134 PYR/PP interface [polypeptide binding]; other site 522373012135 TPP binding site [chemical binding]; other site 522373012136 HMMPfam hit to PF00676, Dehydrogenase E1 component, score 6.8e-40 522373012137 HMMPfam hit to PF02779, Transketolase, pyridine binding domain, score 8.2e-69 522373012138 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 522373012139 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 522373012140 E3 interaction surface; other site 522373012141 lipoyl attachment site [posttranslational modification]; other site 522373012142 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 522373012143 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 6.3e-25 522373012144 HMMPfam hit to PF02817, e3 binding domain, score 5.4e-07 522373012145 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 7.3e-146 522373012146 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 522373012147 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 522373012148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373012149 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 522373012150 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 3.9e-49 522373012151 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 1.1e-32 522373012152 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 4.1e-53 522373012153 2 probable transmembrane helices predicted for Smlt3201 by TMHMM2.0 at aa 56-78 and 82-104 522373012154 PhoD-like phosphatase; Region: PhoD; pfam09423 522373012155 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 522373012156 putative active site [active] 522373012157 putative metal binding site [ion binding]; other site 522373012158 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 522373012159 HMMPfam hit to PF00245, Alkaline phosphatase, score 1.8e-67 522373012160 1 probable transmembrane helix predicted for Smlt3202 by TMHMM2.0 at aa 13-35 522373012161 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373012162 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373012163 N-terminal plug; other site 522373012164 ligand-binding site [chemical binding]; other site 522373012165 HMMPfam hit to PF00593, TonB dependent receptor, score 2.7e-25 522373012166 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.6e-12 522373012167 replicative DNA helicase; Provisional; Region: PRK08760 522373012168 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 522373012169 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 522373012170 Walker A motif; other site 522373012171 ATP binding site [chemical binding]; other site 522373012172 Walker B motif; other site 522373012173 DNA binding loops [nucleotide binding] 522373012174 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 3.5e-140 522373012175 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 3e-52 522373012176 Predicted flavoprotein [General function prediction only]; Region: COG0431 522373012177 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373012178 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 1.1e-25 522373012179 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 522373012180 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 522373012181 active site 522373012182 dimer interface [polypeptide binding]; other site 522373012183 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 522373012184 Ligand Binding Site [chemical binding]; other site 522373012185 Molecular Tunnel; other site 522373012186 HMMPfam hit to PF00733, Asparagine synthase, score 2e-114 522373012187 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 1.1e-08 522373012188 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 522373012189 TPP-binding site [chemical binding]; other site 522373012190 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 522373012191 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 522373012192 PYR/PP interface [polypeptide binding]; other site 522373012193 dimer interface [polypeptide binding]; other site 522373012194 TPP binding site [chemical binding]; other site 522373012195 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 522373012196 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 3.9e-23 522373012197 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 1.5e-16 522373012198 HMMPfam hit to PF00676, Dehydrogenase E1 component, score 1e-07 522373012199 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 522373012200 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 522373012201 putative C-terminal domain interface [polypeptide binding]; other site 522373012202 putative GSH binding site (G-site) [chemical binding]; other site 522373012203 putative dimer interface [polypeptide binding]; other site 522373012204 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 522373012205 N-terminal domain interface [polypeptide binding]; other site 522373012206 dimer interface [polypeptide binding]; other site 522373012207 substrate binding pocket (H-site) [chemical binding]; other site 522373012208 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 5.7e-10 522373012209 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 1.2e-15 522373012210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 522373012211 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 522373012212 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.8e-05 522373012213 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 522373012214 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 3.8e-15 522373012215 1 probable transmembrane helix predicted for Smlt3210 by TMHMM2.0 at aa 28-50 522373012216 1 probable transmembrane helix predicted for Smlt3211 by TMHMM2.0 at aa 20-42 522373012217 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 522373012218 active site 522373012219 HMMPfam hit to PF01026, TatD related DNase, score 1.1e-93 522373012220 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 522373012221 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 522373012222 putative ATP binding site [chemical binding]; other site 522373012223 putative substrate interface [chemical binding]; other site 522373012224 HMMPfam hit to PF00899, ThiF family, score 3.2e-58 522373012225 Cytochrome C' Region: Cytochrom_C_2; cl01610 522373012226 1 probable transmembrane helix predicted for Smlt3214 by TMHMM2.0 at aa 15-37 522373012227 1 probable transmembrane helix predicted for Smlt3215 by TMHMM2.0 at aa 38-60 522373012228 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 1.9e-08 522373012229 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 522373012230 DNA-binding site [nucleotide binding]; DNA binding site 522373012231 RNA-binding motif; other site 522373012232 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 2.5e-39 522373012233 Protein of unknown function (DUF456); Region: DUF456; pfam04306 522373012234 4 probable transmembrane helices predicted for Smlt3217 by TMHMM2.0 at aa 5-39, 54-76, 89-111 and 131-160 522373012235 HMMPfam hit to PF04306, Protein of unknown function (DUF456), score 8.1e-27 522373012236 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 522373012237 dimerization interface [polypeptide binding]; other site 522373012238 substrate binding site [chemical binding]; other site 522373012239 active site 522373012240 calcium binding site [ion binding]; other site 522373012241 HMMPfam hit to PF02253, Phospholipase A1, score 1.3e-56 522373012242 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 522373012243 ArsC family; Region: ArsC; pfam03960 522373012244 catalytic residues [active] 522373012245 HMMPfam hit to PF03960, ArsC family, score 4.1e-32 522373012246 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 522373012247 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 522373012248 C-terminal domain interface [polypeptide binding]; other site 522373012249 GSH binding site (G-site) [chemical binding]; other site 522373012250 dimer interface [polypeptide binding]; other site 522373012251 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 522373012252 dimer interface [polypeptide binding]; other site 522373012253 N-terminal domain interface [polypeptide binding]; other site 522373012254 substrate binding pocket (H-site) [chemical binding]; other site 522373012255 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 2.5e-16 522373012256 putative fumarate hydratase; Provisional; Region: PRK15392 522373012257 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 522373012258 Fumarase C-terminus; Region: Fumerase_C; pfam05683 522373012259 HMMPfam hit to PF05683, Fumarase C-terminus, score 1.6e-118 522373012260 HMMPfam hit to PF05681, Fumarate hydratase (Fumerase), score 2.6e-162 522373012261 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 522373012262 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373012263 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373012264 DNA binding residues [nucleotide binding] 522373012265 HMMPfam hit to PF04542, Sigma-70 region, score 4.1e-09 522373012266 HMMPfam hit to PF08281, Sigma-70, region, score 1.7e-15 522373012267 HMMPfam hit to PF04545, Sigma-70, region, score 5.8e-05 522373012268 Uncharacterized conserved protein [Function unknown]; Region: COG2128 522373012269 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 522373012270 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 2.2e-17 522373012271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373012272 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 522373012273 Walker A/P-loop; other site 522373012274 ATP binding site [chemical binding]; other site 522373012275 Q-loop/lid; other site 522373012276 ABC transporter signature motif; other site 522373012277 Walker B; other site 522373012278 D-loop; other site 522373012279 H-loop/switch region; other site 522373012280 2 probable transmembrane helices predicted for Smlt3226 by TMHMM2.0 at aa 183-205 and 282-304 522373012281 HMMPfam hit to PF00005, ABC transporter score 1.1e-58 522373012282 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 522373012283 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 522373012284 FAD binding pocket [chemical binding]; other site 522373012285 FAD binding motif [chemical binding]; other site 522373012286 phosphate binding motif [ion binding]; other site 522373012287 beta-alpha-beta structure motif; other site 522373012288 NAD binding pocket [chemical binding]; other site 522373012289 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.7e-06 522373012290 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 522373012291 catalytic residues [active] 522373012292 dimer interface [polypeptide binding]; other site 522373012293 HMMPfam hit to PF00255, Glutathione peroxidase, score 2.9e-54 522373012294 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 522373012295 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 522373012296 active site 522373012297 Zn binding site [ion binding]; other site 522373012298 HMMPfam hit to PF01432, Peptidase family M3, score 2.4e-152 522373012299 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 522373012300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373012301 S-adenosylmethionine binding site [chemical binding]; other site 522373012302 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid, score 6.2e-104 522373012303 HMMPfam hit to PF08241, Methyltransferase domain, score 4.6e-16 522373012304 HMMPfam hit to PF08242, Methyltransferase domain, score 1.3e-12 522373012305 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 522373012306 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 522373012307 Predicted acetyltransferase [General function prediction only]; Region: COG2388 522373012308 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 522373012309 6 probable transmembrane helices predicted for Smlt3235 by TMHMM2.0 at aa 4-21, 45-67, 77-99, 111-130, 135-157 and 169-191 522373012310 HMMPfam hit to PF01694, Rhomboid family, score 5.7e-14 522373012311 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 522373012312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373012313 POT family; Region: PTR2; cl17359 522373012314 14 probable transmembrane helices predicted for Smlt3236 by TMHMM2.0 at aa 33-55, 65-84, 91-113, 117-139, 159-178, 182-204, 240-257, 261-283, 304-321, 347-369, 382-401, 411-433, 446-465 and 487-509 522373012315 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.9e-05 522373012316 HMMPfam hit to PF00854, POT family, score 5.8e-29 522373012317 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 522373012318 putative catalytic site [active] 522373012319 putative metal binding site [ion binding]; other site 522373012320 putative phosphate binding site [ion binding]; other site 522373012321 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 522373012322 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 522373012323 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 522373012324 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 2.3e-65 522373012325 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 9.1e-51 522373012326 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 522373012327 active site 522373012328 1 probable transmembrane helix predicted for Smlt3239 by TMHMM2.0 at aa 21-43 522373012329 HMMPfam hit to PF00545, ribonuclease, score 1.5e-12 522373012330 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 522373012331 putative RNAase interaction site [polypeptide binding]; other site 522373012332 1 probable transmembrane helix predicted for Smlt3241 by TMHMM2.0 at aa 97-119 522373012333 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 522373012334 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 522373012335 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 522373012336 HMMPfam hit to PF01106, NifU-like domain, score 4.4e-08 522373012337 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 9.9e-09 522373012338 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 522373012339 aromatic arch; other site 522373012340 DCoH dimer interaction site [polypeptide binding]; other site 522373012341 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 522373012342 DCoH tetramer interaction site [polypeptide binding]; other site 522373012343 substrate binding site [chemical binding]; other site 522373012344 HMMPfam hit to PF01329, Pterin 4 alpha carbinolamine dehydratase, score 1.3e-28 522373012345 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 522373012346 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373012347 zinc transporter ZupT; Provisional; Region: PRK04201 522373012348 8 probable transmembrane helices predicted for Smlt3245 by TMHMM2.0 at aa 10-32, 39-61, 76-95, 124-146, 156-178, 185-207, 217-237 and 250-267 522373012349 HMMPfam hit to PF02535, ZIP Zinc transporter score 1e-23 522373012350 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 522373012351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373012352 RNA binding surface [nucleotide binding]; other site 522373012353 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 522373012354 active site 522373012355 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3.4e-43 522373012356 HMMPfam hit to PF01479, S4 domain, score 2.9e-10 522373012357 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 522373012358 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 522373012359 homodimer interface [polypeptide binding]; other site 522373012360 oligonucleotide binding site [chemical binding]; other site 522373012361 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.3e-15 522373012362 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 522373012363 putative catalytic site [active] 522373012364 putative metal binding site [ion binding]; other site 522373012365 putative phosphate binding site [ion binding]; other site 522373012366 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 3.5e-23 522373012367 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 522373012368 sugar binding site [chemical binding]; other site 522373012369 HMMPfam hit to PF00754, F5/8 type C domain, score 1.9e-16 522373012370 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 522373012371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373012372 dimer interface [polypeptide binding]; other site 522373012373 conserved gate region; other site 522373012374 putative PBP binding loops; other site 522373012375 ABC-ATPase subunit interface; other site 522373012376 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.4e-20 522373012377 6 probable transmembrane helices predicted for Smlt3250 by TMHMM2.0 at aa 13-35, 78-100, 113-132, 136-158, 184-206 and 244-263 522373012378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373012379 dimer interface [polypeptide binding]; other site 522373012380 conserved gate region; other site 522373012381 putative PBP binding loops; other site 522373012382 ABC-ATPase subunit interface; other site 522373012383 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.2e-19 522373012384 6 probable transmembrane helices predicted for Smlt3251 by TMHMM2.0 at aa 7-29, 73-95, 108-130, 161-183, 204-226 and 265-287 522373012385 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 522373012386 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 522373012387 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 3.8e-33 522373012388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 522373012389 Putative glucoamylase; Region: Glycoamylase; pfam10091 522373012390 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 522373012391 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373012392 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373012393 HMMPfam hit to PF00593, TonB dependent receptor, score 1.8e-16 522373012394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 522373012395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 522373012396 DNA binding site [nucleotide binding] 522373012397 domain linker motif; other site 522373012398 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 522373012399 dimerization interface [polypeptide binding]; other site 522373012400 ligand binding site [chemical binding]; other site 522373012401 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 5.9e-12 522373012402 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.7e-12 522373012403 BolA-like protein; Region: BolA; pfam01722 522373012404 HMMPfam hit to PF01722, BolA-like protein, score 4.1e-22 522373012405 YciI-like protein; Reviewed; Region: PRK11370 522373012406 HMMPfam hit to PF03795, YCII-related domain, score 3.3e-38 522373012407 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 522373012408 HMMPfam hit to PF02616, ScpA/B protein, score 8.9e-26 522373012409 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 522373012410 HMMPfam hit to PF04079, Putative transcriptional regulators (Ypuh-li, score 1.7e-79 522373012411 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 522373012412 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373012413 RNA binding surface [nucleotide binding]; other site 522373012414 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 522373012415 active site 522373012416 HMMPfam hit to PF01479, S4 domain, score 8e-12 522373012417 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.1e-10 522373012418 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 522373012419 Helix-turn-helix domain; Region: HTH_18; pfam12833 522373012420 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 0.0001 522373012421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373012422 putative substrate translocation pore; other site 522373012423 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.8e-33 522373012424 11 probable transmembrane helices predicted for Smlt3263 by TMHMM2.0 at aa 35-57, 64-86, 90-112, 125-147, 152-174, 199-221, 232-254, 267-284, 288-310, 317-339 and 343-362 522373012425 C-N hydrolase family amidase; Provisional; Region: PRK10438 522373012426 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 522373012427 putative active site [active] 522373012428 catalytic triad [active] 522373012429 dimer interface [polypeptide binding]; other site 522373012430 multimer interface [polypeptide binding]; other site 522373012431 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 3.8e-14 522373012432 methionine aminotransferase; Validated; Region: PRK09082 522373012433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373012434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373012435 homodimer interface [polypeptide binding]; other site 522373012436 catalytic residue [active] 522373012437 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2e-60 522373012438 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13543 522373012439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373012440 Walker A/P-loop; other site 522373012441 ATP binding site [chemical binding]; other site 522373012442 Q-loop/lid; other site 522373012443 ABC transporter signature motif; other site 522373012444 Walker B; other site 522373012445 D-loop; other site 522373012446 H-loop/switch region; other site 522373012447 HMMPfam hit to PF00005, ABC transporter score 3.4e-34 522373012448 CcmB protein; Region: CcmB; cl17444 522373012449 HMMPfam hit to PF03379, CcmB protein, score 3.4e-76 522373012450 7 probable transmembrane helices predicted for Smlt3269 by TMHMM2.0 at aa 32-49, 56-74, 89-106, 108-130, 140-162, 169-191 and 201-223 522373012451 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 522373012452 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 4.1e-37 522373012453 6 probable transmembrane helices predicted for Smlt3270 by TMHMM2.0 at aa 27-46, 66-88, 95-117, 132-151, 158-180 and 203-225 522373012454 1 probable transmembrane helix predicted for Smlt3271 by TMHMM2.0 at aa 5-27 522373012455 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 522373012456 HMMPfam hit to PF03100, CcmE, score 1e-45 522373012457 1 probable transmembrane helix predicted for Smlt3272 by TMHMM2.0 at aa 9-31 522373012458 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 522373012459 15 probable transmembrane helices predicted for Smlt3273 by TMHMM2.0 at aa 5-27, 40-62, 95-114, 121-143, 175-197, 210-232, 247-264, 271-293, 311-333, 354-376, 391-413, 426-448, 452-474, 487-509 and 613-632 522373012460 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 2.2e-82 522373012461 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 522373012462 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373012463 catalytic residues [active] 522373012464 central insert; other site 522373012465 1 probable transmembrane helix predicted for Smlt3274 by TMHMM2.0 at aa 15-37 522373012466 HMMPfam hit to PF08534, Redoxin, score 3e-19 522373012467 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 522373012468 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 1.4e-44 522373012469 1 probable transmembrane helix predicted for Smlt3275 by TMHMM2.0 at aa 106-128 522373012470 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 522373012471 2 probable transmembrane helices predicted for Smlt3276 by TMHMM2.0 at aa 5-25 and 32-51 522373012472 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.00047 522373012473 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 522373012474 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 522373012475 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.7e-09 522373012476 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 522373012477 3 probable transmembrane helices predicted for Smlt3278 by TMHMM2.0 at aa 7-29, 62-81 and 88-110 522373012478 HMMPfam hit to PF06961, Protein of unknown function (DUF1294), score 1.2e-29 522373012479 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 522373012480 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 522373012481 Walker A/P-loop; other site 522373012482 ATP binding site [chemical binding]; other site 522373012483 Q-loop/lid; other site 522373012484 ABC transporter signature motif; other site 522373012485 Walker B; other site 522373012486 D-loop; other site 522373012487 H-loop/switch region; other site 522373012488 HMMPfam hit to PF00005, ABC transporter score 1.5e-48 522373012489 6 probable transmembrane helices predicted for Smlt3279 by TMHMM2.0 at aa 20-42, 46-68, 139-161, 165-184, 246-268 and 281-303 522373012490 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 522373012491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373012492 Walker A/P-loop; other site 522373012493 ATP binding site [chemical binding]; other site 522373012494 Q-loop/lid; other site 522373012495 ABC transporter signature motif; other site 522373012496 Walker B; other site 522373012497 D-loop; other site 522373012498 H-loop/switch region; other site 522373012499 HMMPfam hit to PF00005, ABC transporter score 2e-61 522373012500 6 probable transmembrane helices predicted for Smlt3280 by TMHMM2.0 at aa 41-63, 73-95, 151-173, 178-200, 260-282 and 295-317 522373012501 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 522373012502 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 522373012503 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 1.5e-257 522373012504 9 probable transmembrane helices predicted for Smlt3282 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 131-153, 187-209, 221-240, 389-411, 424-446 and 468-490 522373012505 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 522373012506 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 522373012507 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 1.1e-154 522373012508 8 probable transmembrane helices predicted for Smlt3283 by TMHMM2.0 at aa 13-32, 82-104, 125-147, 172-194, 207-229, 266-288, 295-317 and 341-363 522373012509 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 522373012510 HMMPfam hit to PF08173, Membrane bound YbgT-like protein, score 2.1e-13 522373012511 1 probable transmembrane helix predicted for Smlt3284 by TMHMM2.0 at aa 4-26 522373012512 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 522373012513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373012514 12 probable transmembrane helices predicted for Smlt3287 by TMHMM2.0 at aa 12-34, 49-71, 84-103, 108-130, 142-164, 169-191, 216-238, 248-270, 282-304, 308-330, 337-359 and 369-391 522373012515 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3e-22 522373012516 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 522373012517 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 522373012518 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 522373012519 putative active site [active] 522373012520 putative metal binding site [ion binding]; other site 522373012521 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 5e-29 522373012522 N-glycosyltransferase; Provisional; Region: PRK11204 522373012523 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 522373012524 DXD motif; other site 522373012525 4 probable transmembrane helices predicted for Smlt3291 by TMHMM2.0 at aa 30-52, 321-343, 358-380 and 393-415 522373012526 HMMPfam hit to PF00535, Glycosyl transferase family, score 2.5e-30 522373012527 PgaD-like protein; Region: PgaD; pfam13994 522373012528 2 probable transmembrane helices predicted for Smlt3292 by TMHMM2.0 at aa 33-55 and 75-97 522373012529 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 522373012530 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 522373012531 putative catalytic cysteine [active] 522373012532 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.9e-07 522373012533 gamma-glutamyl kinase; Provisional; Region: PRK05429 522373012534 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 522373012535 nucleotide binding site [chemical binding]; other site 522373012536 PUA domain; Region: PUA; pfam01472 522373012537 HMMPfam hit to PF01472, PUA domain, score 7.7e-24 522373012538 HMMPfam hit to PF00696, Amino acid kinase family, score 1.7e-54 522373012539 YCII-related domain; Region: YCII; cl00999 522373012540 HMMPfam hit to PF03795, YCII-related domain, score 7.9e-08 522373012541 argininosuccinate lyase; Provisional; Region: PRK00855 522373012542 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 522373012543 active sites [active] 522373012544 tetramer interface [polypeptide binding]; other site 522373012545 HMMPfam hit to PF00206, Lyase, score 3.5e-30 522373012546 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 522373012547 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 522373012548 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 2.1e-06 522373012549 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 2.4e-36 522373012550 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 522373012551 acetylglutamate kinase; Provisional; Region: PRK04531 522373012552 AAK_NAGK-fArgBP: N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal...; Region: AAK_NAGK-fArgBP; cd04252 522373012553 putative nucleotide binding site [chemical binding]; other site 522373012554 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 522373012555 DUF619 domain of various N-acetylglutamate Synthases of the fungal arginine-biosynthetic pathway and urea cycle found in humans and fish; Region: DUF619-NAGS; cd04264 522373012556 HMMPfam hit to PF04768, Protein of unknown function (DUF619), score 1.9e-70 522373012557 HMMPfam hit to PF00696, Amino acid kinase family, score 8.3e-28 522373012558 acetylornithine deacetylase; Provisional; Region: PRK08737 522373012559 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 522373012560 metal binding site [ion binding]; metal-binding site 522373012561 putative dimer interface [polypeptide binding]; other site 522373012562 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1.7e-20 522373012563 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 4.2e-19 522373012564 argininosuccinate synthase; Provisional; Region: PRK13820 522373012565 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 522373012566 ANP binding site [chemical binding]; other site 522373012567 Substrate Binding Site II [chemical binding]; other site 522373012568 Substrate Binding Site I [chemical binding]; other site 522373012569 HMMPfam hit to PF00764, Arginosuccinate synthase, score 1.1e-71 522373012570 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 522373012571 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 522373012572 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 522373012573 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 7.7e-10 522373012574 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 1.9e-17 522373012575 1 probable transmembrane helix predicted for Smlt3303 by TMHMM2.0 at aa 40-62 522373012576 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 522373012577 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 522373012578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 522373012579 active site 522373012580 HIGH motif; other site 522373012581 nucleotide binding site [chemical binding]; other site 522373012582 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 522373012583 KMSKS motif; other site 522373012584 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 522373012585 tRNA binding surface [nucleotide binding]; other site 522373012586 anticodon binding site; other site 522373012587 HMMPfam hit to PF01406, tRNA synthetases class I (C) catalytic d, score 1.4e-151 522373012588 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 522373012589 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 9.4e-31 522373012590 H+ Antiporter protein; Region: 2A0121; TIGR00900 522373012591 HMMPfam hit to PF05977, Bacterial protein of unknown function (DUF89, score 0.00056 522373012592 11 probable transmembrane helices predicted for Smlt3307 by TMHMM2.0 at aa 23-45, 55-77, 84-106, 116-138, 150-172, 182-199, 229-251, 266-283, 295-312, 316-335 and 379-401 522373012593 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.4e-33 522373012594 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 522373012595 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 4.5e-08 522373012596 hypothetical protein; Validated; Region: PRK00041 522373012597 HMMPfam hit to PF01809, Domain of unknown function DUF37, score 1.5e-42 522373012598 dihydroorotase; Reviewed; Region: PRK09236 522373012599 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 522373012600 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 522373012601 active site 522373012602 HMMPfam hit to PF01979, Amidohydrolase family, score 3e-05 522373012603 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 522373012604 Peptidase family M23; Region: Peptidase_M23; pfam01551 522373012605 1 probable transmembrane helix predicted for Smlt3311 by TMHMM2.0 at aa 19-41 522373012606 HMMPfam hit to PF01551, Peptidase family M23, score 2.4e-45 522373012607 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 522373012608 phosphoglycolate phosphatase; Provisional; Region: PRK13226 522373012609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373012610 motif II; other site 522373012611 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 522373012612 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.7e-31 522373012613 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 522373012614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373012615 S-adenosylmethionine binding site [chemical binding]; other site 522373012616 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid, score 0.0015 522373012617 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 0.00023 522373012618 HMMPfam hit to PF05724, Thiopurine S-methyltransferase (TPMT), score 0.00017 522373012619 HMMPfam hit to PF05401, Nodulation protein S (NodS), score 0.00061 522373012620 HMMPfam hit to PF05175, Methyltransferase small domain, score 3.3e-05 522373012621 HMMPfam hit to PF08241, Methyltransferase domain, score 4.3e-34 522373012622 HMMPfam hit to PF08242, Methyltransferase domain, score 8.1e-25 522373012623 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 522373012624 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 522373012625 active site 522373012626 putative substrate binding pocket [chemical binding]; other site 522373012627 HMMPfam hit to PF01979, Amidohydrolase family, score 6.3e-69 522373012628 HMMPfam hit to PF07969, Amidohydrolase family, score 0.00012 522373012629 elongation factor P; Validated; Region: PRK00529 522373012630 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 522373012631 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 522373012632 RNA binding site [nucleotide binding]; other site 522373012633 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 522373012634 RNA binding site [nucleotide binding]; other site 522373012635 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 7.2e-18 522373012636 HMMPfam hit to PF08207, Elongation factor P (EF-P) KOW-like domain, score 4.5e-17 522373012637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373012638 Radical SAM superfamily; Region: Radical_SAM; pfam04055 522373012639 FeS/SAM binding site; other site 522373012640 HMMPfam hit to PF04055, Radical SAM superfamily, score 3.8e-07 522373012641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 522373012642 dimerization interface [polypeptide binding]; other site 522373012643 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373012644 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373012645 metal binding site [ion binding]; metal-binding site 522373012646 active site 522373012647 I-site; other site 522373012648 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373012649 HMMPfam hit to PF00563, EAL domain, score 1.7e-111 522373012650 HMMPfam hit to PF00990, GGDEF domain, score 2.2e-51 522373012651 HMMPfam hit to PF00672, HAMP domain, score 7.7e-17 522373012652 2 probable transmembrane helices predicted for Smlt3318 by TMHMM2.0 at aa 10-32 and 195-217 522373012653 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 522373012654 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 522373012655 membrane-bound complex binding site; other site 522373012656 hinge residues; other site 522373012657 1 probable transmembrane helix predicted for Smlt3319 by TMHMM2.0 at aa 13-30 522373012658 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 522373012659 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 522373012660 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 5e-38 522373012661 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 522373012662 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 522373012663 active site 522373012664 dimerization interface [polypeptide binding]; other site 522373012665 HMMPfam hit to PF00459, Inositol monophosphatase family, score 4.2e-78 522373012666 heat shock protein HtpX; Provisional; Region: PRK05457 522373012667 HMMPfam hit to PF01435, Peptidase family M48, score 8.2e-43 522373012668 4 probable transmembrane helices predicted for Smlt3323 by TMHMM2.0 at aa 5-27, 32-54, 153-175 and 190-212 522373012669 HMMPfam hit to PF06509, HtpX N-terminus, score 2.1e-51 522373012670 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 522373012671 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 522373012672 active site 522373012673 HIGH motif; other site 522373012674 nucleotide binding site [chemical binding]; other site 522373012675 KMSKS motif; other site 522373012676 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 1.1e-28 522373012677 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 522373012678 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 522373012679 NAD(P) binding site [chemical binding]; other site 522373012680 homotetramer interface [polypeptide binding]; other site 522373012681 homodimer interface [polypeptide binding]; other site 522373012682 active site 522373012683 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.4e-44 522373012684 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 4.1e-06 522373012685 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 522373012686 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 522373012687 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 522373012688 HMMPfam hit to PF07879, PHB/PHA accumulation regulator DNA-binding, score 7.9e-41 522373012689 HMMPfam hit to PF05233, PHB accumulation regulatory domain, score 6.5e-17 522373012690 TraB family; Region: TraB; pfam01963 522373012691 HMMPfam hit to PF07446, GumN protein, score 1.6e-77 522373012692 1 probable transmembrane helix predicted for Smlt3327 by TMHMM2.0 at aa 37-56 522373012693 Uncharacterized conserved protein [Function unknown]; Region: COG3358 522373012694 HMMPfam hit to PF07920, Protein of unknown function (DUF1684), score 1.1e-84 522373012695 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 522373012696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373012697 ATP binding site [chemical binding]; other site 522373012698 Mg2+ binding site [ion binding]; other site 522373012699 G-X-G motif; other site 522373012700 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 522373012701 ATP binding site [chemical binding]; other site 522373012702 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 522373012703 HMMPfam hit to PF01119, DNA mismatch repair protein, C-termina, score 3e-36 522373012704 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and, score 7.2e-11 522373012705 AMIN domain; Region: AMIN; pfam11741 522373012706 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 522373012707 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 522373012708 active site 522373012709 metal binding site [ion binding]; metal-binding site 522373012710 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 1.5e-85 522373012711 1 probable transmembrane helix predicted for Smlt3330 by TMHMM2.0 at aa 7-26 522373012712 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 522373012713 HMMPfam hit to PF02367, Uncharacterised P-loop hydrolase UPF0079, score 2e-26 522373012714 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 522373012715 putative carbohydrate kinase; Provisional; Region: PRK10565 522373012716 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 522373012717 putative substrate binding site [chemical binding]; other site 522373012718 putative ATP binding site [chemical binding]; other site 522373012719 HMMPfam hit to PF01256, Carbohydrate kinase, score 1e-72 522373012720 HMMPfam hit to PF03853, YjeF-related protein N-terminus, score 6.7e-42 522373012721 epoxyqueuosine reductase; Region: TIGR00276 522373012722 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 522373012723 HMMPfam hit to PF08331, Domain of unknown function (DUF1730), score 4.3e-37 522373012724 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0017 522373012725 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 522373012726 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 522373012727 generic binding surface II; other site 522373012728 generic binding surface I; other site 522373012729 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.7e-11 522373012730 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 1.1e-39 522373012731 Peptidase family M48; Region: Peptidase_M48; pfam01435 522373012732 HMMPfam hit to PF01435, Peptidase family M48, score 4.7e-45 522373012733 1 probable transmembrane helix predicted for Smlt3336 by TMHMM2.0 at aa 32-54 522373012734 Uncharacterized conserved protein [Function unknown]; Region: COG1262 522373012735 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 522373012736 HMMPfam hit to PF03781, Domain of unknown function (DUF323), score 2.9e-89 522373012737 ribonuclease D; Region: rnd; TIGR01388 522373012738 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 522373012739 catalytic site [active] 522373012740 putative active site [active] 522373012741 putative substrate binding site [chemical binding]; other site 522373012742 HMMPfam hit to PF01612, 3'-5' exonuclease, score 1.3e-31 522373012743 HMMPfam hit to PF00570, HRDC domain, score 0.00038 522373012744 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 522373012745 HMMPfam hit to PF08238, Sel1 repeat, score 0.43 522373012746 HMMPfam hit to PF08238, Sel1 repeat, score 0.036 522373012747 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373012748 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373012749 N-terminal plug; other site 522373012750 ligand-binding site [chemical binding]; other site 522373012751 HMMPfam hit to PF00593, TonB dependent receptor, score 2.7e-20 522373012752 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.3e-14 522373012753 short chain dehydrogenase; Provisional; Region: PRK07478 522373012754 classical (c) SDRs; Region: SDR_c; cd05233 522373012755 NAD(P) binding site [chemical binding]; other site 522373012756 active site 522373012757 HMMPfam hit to PF00106, short chain dehydrogenase, score 3.1e-32 522373012758 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 522373012759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373012760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373012761 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 522373012762 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 522373012763 DNA binding site [nucleotide binding] 522373012764 active site 522373012765 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix, score 7.9e-09 522373012766 HMMPfam hit to PF02870, 6-O-methylguanine DNA methyltransfera, score 0.0066 522373012767 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransfera, score 7.8e-49 522373012768 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 522373012769 Prostaglandin dehydrogenases; Region: PGDH; cd05288 522373012770 NAD(P) binding site [chemical binding]; other site 522373012771 substrate binding site [chemical binding]; other site 522373012772 dimer interface [polypeptide binding]; other site 522373012773 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.3e-29 522373012774 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 522373012775 HMMPfam hit to PF08212, Lipocalin-like domain, score 7.9e-73 522373012776 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 522373012777 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 522373012778 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 522373012779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 522373012780 active site 522373012781 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 522373012782 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 2.2e-17 522373012783 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 9.2e-26 522373012784 HMMPfam hit to PF08028, Acyl-CoA dehydrogenase, C-terminal doma, score 0.00052 522373012785 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 522373012786 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 522373012787 active site 522373012788 HMMPfam hit to PF01844, HNH endonuclease, score 1.8e-09 522373012789 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 522373012790 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 522373012791 TPP-binding site; other site 522373012792 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 522373012793 PYR/PP interface [polypeptide binding]; other site 522373012794 dimer interface [polypeptide binding]; other site 522373012795 TPP binding site [chemical binding]; other site 522373012796 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 522373012797 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 6.5e-54 522373012798 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 6.6e-31 522373012799 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 522373012800 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 522373012801 HMMPfam hit to PF07866, Protein of unknown function (DUF1653), score 2.7e-35 522373012802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373012803 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 3.9e-18 522373012804 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 522373012805 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 3.2e-46 522373012806 3 probable transmembrane helices predicted for Smlt3363 by TMHMM2.0 at aa 30-49, 56-78 and 83-105 522373012807 2 probable transmembrane helices predicted for Smlt3364 by TMHMM2.0 at aa 7-29 and 33-52 522373012808 HMMPfam hit to PF07043, Protein of unknown function (DUF1328), score 5e-19 522373012809 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 522373012810 HMMPfam hit to PF01810, LysE type translocator, score 2.2e-32 522373012811 4 probable transmembrane helices predicted for Smlt3365 by TMHMM2.0 at aa 42-64, 79-101, 190-212 and 227-246 522373012812 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 522373012813 aspartate racemase; Region: asp_race; TIGR00035 522373012814 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase, score 1.1e-58 522373012815 conserved hypothetical exported protein, pseudogene;similarity:fasta; with=UniProt:Q2P583 (EMBL:AP008229;); Xanthomonas oryzae pv. oryzae (strain MAFF 311018).; Hypothetical protein XOO1539.; length=258; id 38.824%; ungapped id 40.741%; E()=2.7e-18; 170 aa overlap; query 3-166; subject 2-169 522373012816 3 probable transmembrane helices predicted for Smlt3369 by TMHMM2.0 at aa 30-52, 65-87 and 92-114 522373012817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 522373012818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373012819 Coenzyme A binding pocket [chemical binding]; other site 522373012820 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.5e-15 522373012821 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 522373012822 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 522373012823 DNA binding residues [nucleotide binding] 522373012824 HMMPfam hit to PF00376, MerR family regulatory protein, score 2.5e-08 522373012825 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 522373012826 IHF dimer interface [polypeptide binding]; other site 522373012827 IHF - DNA interface [nucleotide binding]; other site 522373012828 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 1.5e-45 522373012829 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 522373012830 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 522373012831 putative tRNA-binding site [nucleotide binding]; other site 522373012832 B3/4 domain; Region: B3_4; pfam03483 522373012833 tRNA synthetase B5 domain; Region: B5; smart00874 522373012834 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 522373012835 dimer interface [polypeptide binding]; other site 522373012836 motif 1; other site 522373012837 motif 3; other site 522373012838 motif 2; other site 522373012839 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 522373012840 HMMPfam hit to PF03147, Ferredoxin-fold anticodon binding domain, score 7.7e-32 522373012841 HMMPfam hit to PF03484, tRNA synthetase B5 domain, score 4.1e-29 522373012842 HMMPfam hit to PF03483, B3/4 domain, score 8e-93 522373012843 HMMPfam hit to PF01588, Putative tRNA binding domain, score 2e-34 522373012844 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 522373012845 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 522373012846 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 522373012847 dimer interface [polypeptide binding]; other site 522373012848 motif 1; other site 522373012849 active site 522373012850 motif 2; other site 522373012851 motif 3; other site 522373012852 HMMPfam hit to PF01409, tRNA synthetases class II core domain, score 6.3e-158 522373012853 HMMPfam hit to PF02912, Aminoacyl tRNA synthetase class II, N, score 3.7e-31 522373012854 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 522373012855 23S rRNA binding site [nucleotide binding]; other site 522373012856 L21 binding site [polypeptide binding]; other site 522373012857 L13 binding site [polypeptide binding]; other site 522373012858 HMMPfam hit to PF00453, Ribosomal protein L20, score 1.6e-55 522373012859 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 522373012860 HMMPfam hit to PF01632, Ribosomal protein L35, score 7.1e-26 522373012861 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 522373012862 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 522373012863 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 522373012864 HMMPfam hit to PF00707, Translation initiation factor IF-3, C-termin, score 2.3e-45 522373012865 HMMPfam hit to PF05198, Translation initiation factor IF-3, N-termin, score 1.1e-48 522373012866 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 522373012867 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 522373012868 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 522373012869 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 522373012870 active site 522373012871 dimer interface [polypeptide binding]; other site 522373012872 motif 1; other site 522373012873 motif 2; other site 522373012874 motif 3; other site 522373012875 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 522373012876 anticodon binding site; other site 522373012877 HMMPfam hit to PF03129, Anticodon binding domain, score 2.7e-28 522373012878 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 9.9e-57 522373012879 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase se, score 7.5e-23 522373012880 HMMPfam hit to PF02824, TGS domain, score 1.1e-13 522373012881 3 probable transmembrane helices predicted for Smlt3379 by TMHMM2.0 at aa 55-77, 92-109 and 116-138 522373012882 3 probable transmembrane helices predicted for Smlt3380 by TMHMM2.0 at aa 7-29, 34-56 and 63-85 522373012883 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 522373012884 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 522373012885 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 522373012886 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.75 522373012887 8 probable transmembrane helices predicted for Smlt3381 by TMHMM2.0 at aa 13-35, 136-158, 193-215, 345-367, 388-410, 420-437, 449-466 and 481-503 522373012888 HMMPfam hit to PF03929, PepSY-associated TM helix, score 1 522373012889 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.00064 522373012890 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.27 522373012891 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 522373012892 dimer interface [polypeptide binding]; other site 522373012893 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373012894 metal binding site [ion binding]; metal-binding site 522373012895 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 4e-15 522373012896 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 522373012897 Glyco_18 domain; Region: Glyco_18; smart00636 522373012898 active site 522373012899 HMMPfam hit to PF00704, Glycosyl hydrolases family, score 3.6e-86 522373012900 1 probable transmembrane helix predicted for Smlt3383 by TMHMM2.0 at aa 7-26 522373012901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373012902 binding surface 522373012903 TPR repeat; Region: TPR_11; pfam13414 522373012904 TPR motif; other site 522373012905 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.007 522373012906 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 522373012907 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 522373012908 RNase E interface [polypeptide binding]; other site 522373012909 trimer interface [polypeptide binding]; other site 522373012910 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 522373012911 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 522373012912 RNase E interface [polypeptide binding]; other site 522373012913 trimer interface [polypeptide binding]; other site 522373012914 active site 522373012915 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 522373012916 putative nucleic acid binding region [nucleotide binding]; other site 522373012917 G-X-X-G motif; other site 522373012918 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 522373012919 RNA binding site [nucleotide binding]; other site 522373012920 domain interface; other site 522373012921 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.2e-25 522373012922 HMMPfam hit to PF00013, KH domain, score 6.3e-16 522373012923 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 2.8e-23 522373012924 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 2.6e-49 522373012925 HMMPfam hit to PF03726, Polyribonucleotide nucleotidyltransferase,, score 1.1e-18 522373012926 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 2.2e-12 522373012927 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 1.2e-37 522373012928 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 522373012929 16S/18S rRNA binding site [nucleotide binding]; other site 522373012930 S13e-L30e interaction site [polypeptide binding]; other site 522373012931 25S rRNA binding site [nucleotide binding]; other site 522373012932 HMMPfam hit to PF00312, Ribosomal protein S15, score 5.4e-37 522373012933 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04642 522373012934 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 522373012935 RNA binding site [nucleotide binding]; other site 522373012936 active site 522373012937 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 522373012938 HMMPfam hit to PF01509, TruB family pseudouridylate synthase (N term, score 5.2e-53 522373012939 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 522373012940 HMMPfam hit to PF02033, Ribosome-binding factor A, score 3.8e-23 522373012941 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 522373012942 translation initiation factor IF-2; Region: IF-2; TIGR00487 522373012943 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 522373012944 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 522373012945 G1 box; other site 522373012946 putative GEF interaction site [polypeptide binding]; other site 522373012947 GTP/Mg2+ binding site [chemical binding]; other site 522373012948 Switch I region; other site 522373012949 G2 box; other site 522373012950 G3 box; other site 522373012951 Switch II region; other site 522373012952 G4 box; other site 522373012953 G5 box; other site 522373012954 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 522373012955 Translation-initiation factor 2; Region: IF-2; pfam11987 522373012956 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 522373012957 HMMPfam hit to PF03144, Elongation factor Tu domain, score 6e-08 522373012958 HMMPfam hit to PF03144, Elongation factor Tu domain, score 6.6e-11 522373012959 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 6.9e-52 522373012960 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 1.4e-20 522373012961 HMMPfam hit to PF08364, Bacterial translation initiation factor I, score 1.1e-12 522373012962 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 522373012963 NusA N-terminal domain; Region: NusA_N; pfam08529 522373012964 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 522373012965 RNA binding site [nucleotide binding]; other site 522373012966 homodimer interface [polypeptide binding]; other site 522373012967 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 522373012968 G-X-X-G motif; other site 522373012969 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 522373012970 G-X-X-G motif; other site 522373012971 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 522373012972 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 522373012973 HMMPfam hit to PF00013, KH domain, score 0.017 522373012974 HMMPfam hit to PF00575, S1 RNA binding domain, score 9e-10 522373012975 HMMPfam hit to PF08529, NusA N-terminal domain, score 2.7e-61 522373012976 ribosome maturation protein RimP; Reviewed; Region: PRK00092 522373012977 Sm and related proteins; Region: Sm_like; cl00259 522373012978 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 522373012979 putative oligomer interface [polypeptide binding]; other site 522373012980 putative RNA binding site [nucleotide binding]; other site 522373012981 HMMPfam hit to PF02576, Uncharacterised BCR, YhbC family COG0779, score 2.3e-64 522373012982 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 522373012983 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 522373012984 12 probable transmembrane helices predicted for Smlt3392 by TMHMM2.0 at aa 20-39, 46-68, 88-105, 118-140, 170-189, 210-232, 277-299, 306-328, 332-354, 375-397, 412-434 and 454-476 522373012985 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 7.5e-73 522373012986 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 522373012987 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 522373012988 14 probable transmembrane helices predicted for Smlt3393 by TMHMM2.0 at aa 4-23, 30-52, 83-105, 112-129, 134-156, 163-185, 205-227, 239-261, 271-293, 300-322, 337-359, 380-402, 417-436 and 461-478 522373012989 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 5.9e-95 522373012990 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 522373012991 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 522373012992 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 522373012993 16 probable transmembrane helices predicted for Smlt3394 by TMHMM2.0 at aa 10-27, 34-56, 90-112, 119-138, 142-164, 177-199, 236-255, 276-295, 305-327, 334-356, 360-382, 403-422, 445-467, 518-540, 596-618 and 695-717 522373012994 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex, score 2.3e-103 522373012995 HMMPfam hit to PF00662, NADH-Ubiquinone oxidoreductase (complex, score 1.3e-23 522373012996 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 522373012997 HMMPfam hit to PF00420, NADH-ubiquinone/plastoquinone oxidoreduct, score 2.7e-41 522373012998 3 probable transmembrane helices predicted for Smlt3395 by TMHMM2.0 at aa 5-24, 29-51 and 61-83 522373012999 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 522373013000 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 522373013001 5 probable transmembrane helices predicted for Smlt3396 by TMHMM2.0 at aa 6-25, 32-49, 53-75, 88-110 and 147-169 522373013002 HMMPfam hit to PF00499, NADH-ubiquinone/plastoquinone oxidoreduct, score 4.4e-36 522373013003 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 522373013004 4Fe-4S binding domain; Region: Fer4; pfam00037 522373013005 4Fe-4S binding domain; Region: Fer4; pfam00037 522373013006 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 3.4e-06 522373013007 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.6e-05 522373013008 1 probable transmembrane helix predicted for Smlt3397 by TMHMM2.0 at aa 7-29 522373013009 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 522373013010 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 522373013011 10 probable transmembrane helices predicted for Smlt3398 by TMHMM2.0 at aa 24-46, 53-75, 95-114, 127-149, 167-189, 202-224, 239-257, 264-286, 301-320 and 339-361 522373013012 HMMPfam hit to PF00146, NADH dehydrogenase, score 2.1e-142 522373013013 NADH dehydrogenase subunit G; Validated; Region: PRK09129 522373013014 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 522373013015 catalytic loop [active] 522373013016 iron binding site [ion binding]; other site 522373013017 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 522373013018 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 522373013019 molybdopterin cofactor binding site; other site 522373013020 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 522373013021 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 0.001 522373013022 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.4e-18 522373013023 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding do, score 2.3e-12 522373013024 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 522373013025 SLBB domain; Region: SLBB; pfam10531 522373013026 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 522373013027 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase, score 7.5e-122 522373013028 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 522373013029 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 522373013030 putative dimer interface [polypeptide binding]; other site 522373013031 [2Fe-2S] cluster binding site [ion binding]; other site 522373013032 HMMPfam hit to PF01257, Respiratory-chain NADH dehydrogenase, score 1.9e-48 522373013033 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 522373013034 NADH dehydrogenase subunit D; Validated; Region: PRK06075 522373013035 HMMPfam hit to PF00346, Respiratory-chain NADH dehydrogenase,, score 2.4e-154 522373013036 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 522373013037 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 522373013038 HMMPfam hit to PF00329, Respiratory-chain NADH dehydrogenase,, score 2e-40 522373013039 NADH dehydrogenase subunit B; Validated; Region: PRK06411 522373013040 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 2.4e-63 522373013041 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 522373013042 HMMPfam hit to PF00507, NADH-ubiquinone/plastoquinone oxidoreduct, score 2e-46 522373013043 3 probable transmembrane helices predicted for Smlt3405 by TMHMM2.0 at aa 21-43, 74-96 and 103-125 522373013044 Preprotein translocase SecG subunit; Region: SecG; pfam03840 522373013045 2 probable transmembrane helices predicted for Smlt3406 by TMHMM2.0 at aa 2-24 and 59-76 522373013046 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 7.7e-29 522373013047 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 522373013048 substrate binding site [chemical binding]; other site 522373013049 dimer interface [polypeptide binding]; other site 522373013050 catalytic triad [active] 522373013051 HMMPfam hit to PF00121, Triosephosphate isomerase, score 1.2e-130 522373013052 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 522373013053 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 522373013054 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 522373013055 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 3.7e-16 522373013056 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 522373013057 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 522373013058 Sulfatase; Region: Sulfatase; cl17466 522373013059 4 probable transmembrane helices predicted for Smlt3410 by TMHMM2.0 at aa 15-37, 50-72, 101-123 and 135-154 522373013060 HMMPfam hit to PF00884, Sulfatase, score 8.3e-27 522373013061 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 522373013062 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 522373013063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 522373013064 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.6e-37 522373013065 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 522373013066 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 522373013067 putative active site [active] 522373013068 putative metal binding site [ion binding]; other site 522373013069 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 8.2e-36 522373013070 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 522373013071 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 522373013072 NAD binding site [chemical binding]; other site 522373013073 homodimer interface [polypeptide binding]; other site 522373013074 active site 522373013075 substrate binding site [chemical binding]; other site 522373013076 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.1e-05 522373013077 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 4e-69 522373013078 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 0.00043 522373013079 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 1e-09 522373013080 HMMPfam hit to PF07993, Male sterility protein, score 0.00015 522373013081 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 522373013082 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 522373013083 active site 522373013084 substrate binding site [chemical binding]; other site 522373013085 metal binding site [ion binding]; metal-binding site 522373013086 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 4.4e-06 522373013087 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 1.4e-21 522373013088 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 2.2e-36 522373013089 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 9.4e-60 522373013090 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 522373013091 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 522373013092 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 522373013093 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 522373013094 substrate binding site [chemical binding]; other site 522373013095 active site 522373013096 catalytic residues [active] 522373013097 heterodimer interface [polypeptide binding]; other site 522373013098 HMMPfam hit to PF00290, Tryptophan synthase alpha chain, score 3.4e-93 522373013099 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 522373013100 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 522373013101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373013102 catalytic residue [active] 522373013103 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 2.9e-123 522373013104 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 522373013105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373013106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373013107 dimerization interface [polypeptide binding]; other site 522373013108 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.3e-18 522373013109 HMMPfam hit to PF03466, LysR substrate binding domain, score 7.9e-26 522373013110 conserved hypothetical protein, pseudogene;Similar to C-terminus of xanthomonas campestris pv. campestris. lytic enzyme. UniProt:Q8PD91 (EMBL:AE012142 (576 aa) fasta scores: E()=3e-10, 70.000% id in 50 aa; similarity:fasta; with=UniProt:Q8PD91 (EMBL:AE012142;); Xanthomonas campestris pv. campestris.; Lytic enzyme.; length=576; id 70.000%; ungapped id 70.000%; E()=3e-10; 50 aa overlap; query 1-50; subject 527-576 522373013111 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 522373013112 active site 522373013113 HMMPfam hit to PF00697, N-(5'phosphoribosyl)anthranilate (PRA) isome, score 8.8e-48 522373013114 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 522373013115 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 522373013116 dimerization interface 3.5A [polypeptide binding]; other site 522373013117 active site 522373013118 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 2.8e-28 522373013119 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 2.3e-31 522373013120 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373013121 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 522373013122 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 4.5e-10 522373013123 FimV N-terminal domain; Region: FimV_core; TIGR03505 522373013124 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 522373013125 1 probable transmembrane helix predicted for Smlt3426 by TMHMM2.0 at aa 45-67 522373013126 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 522373013127 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 522373013128 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 2.5e-78 522373013129 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 2.7e-32 522373013130 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 522373013131 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 522373013132 dimerization interface [polypeptide binding]; other site 522373013133 ligand binding site [chemical binding]; other site 522373013134 NADP binding site [chemical binding]; other site 522373013135 catalytic site [active] 522373013136 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 4.5e-25 522373013137 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 4.2e-90 522373013138 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 522373013139 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 522373013140 Tetramer interface [polypeptide binding]; other site 522373013141 active site 522373013142 FMN-binding site [chemical binding]; other site 522373013143 HMMPfam hit to PF01264, Chorismate synthase, score 2.7e-182 522373013144 HemK family putative methylases; Region: hemK_fam; TIGR00536 522373013145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373013146 S-adenosylmethionine binding site [chemical binding]; other site 522373013147 HMMPfam hit to PF05175, Methyltransferase small domain, score 2.3e-09 522373013148 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 522373013149 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 522373013150 Cu(I) binding site [ion binding]; other site 522373013151 1 probable transmembrane helix predicted for Smlt3431 by TMHMM2.0 at aa 7-29 522373013152 HMMPfam hit to PF02630, SCO1/SenC, score 7.5e-11 522373013153 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 522373013154 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase, score 1.3e-55 522373013155 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 522373013156 HMMPfam hit to PF06877, Protein of unknown function (DUF1260), score 0.0013 522373013157 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 522373013158 N-acetyl-D-glucosamine binding site [chemical binding]; other site 522373013159 catalytic residue [active] 522373013160 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 522373013161 HMMPfam hit to PF01476, LysM domain, score 1.1e-12 522373013162 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 2.3e-22 522373013163 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 522373013164 HMMPfam hit to PF05872, Bacterial protein of unknown function (DUF85, score 0 522373013165 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 522373013166 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 522373013167 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 522373013168 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 3.5e-34 522373013169 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 5.6e-31 522373013170 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 522373013171 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 522373013172 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 522373013173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373013174 FeS/SAM binding site; other site 522373013175 HMMPfam hit to PF04055, Radical SAM superfamily, score 7.9e-31 522373013176 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 5.5e-41 522373013177 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 522373013178 HMMPfam hit to PF01738, Dienelactone hydrolase family, score 1.4e-32 522373013179 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 522373013180 nucleotide binding site/active site [active] 522373013181 HIT family signature motif; other site 522373013182 catalytic residue [active] 522373013183 HMMPfam hit to PF01230, HIT domain, score 2e-07 522373013184 2 probable transmembrane helices predicted for Smlt3441 by TMHMM2.0 at aa 3-25 and 35-52 522373013185 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 522373013186 trimer interface [polypeptide binding]; other site 522373013187 active site 522373013188 HMMPfam hit to PF00692, dUTPase, score 0.0033 522373013189 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 522373013190 2 probable transmembrane helices predicted for Smlt3444 by TMHMM2.0 at aa 20-42 and 55-72 522373013191 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 522373013192 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373013193 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373013194 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 9.9e-18 522373013195 HMMPfam hit to PF00593, TonB dependent receptor, score 1.2e-24 522373013196 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373013197 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373013198 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 9.9e-19 522373013199 HMMPfam hit to PF00593, TonB dependent receptor, score 4.8e-26 522373013200 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 522373013201 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 522373013202 active site 522373013203 Zn binding site [ion binding]; other site 522373013204 HMMPfam hit to PF05649, Peptidase family M13, score 2.2e-174 522373013205 HMMPfam hit to PF01431, Peptidase family M13, score 8.1e-84 522373013206 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 522373013207 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373013208 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373013209 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.1e-12 522373013210 HMMPfam hit to PF00593, TonB dependent receptor, score 9.5e-17 522373013211 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 522373013212 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 522373013213 active site 522373013214 Zn binding site [ion binding]; other site 522373013215 HMMPfam hit to PF05649, Peptidase family M13, score 1.8e-133 522373013216 HMMPfam hit to PF01431, Peptidase family M13, score 6.5e-32 522373013217 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 522373013218 dimer interface [polypeptide binding]; other site 522373013219 HMMPfam hit to PF06983, 3-demethylubiquinone-9 3-methyltransfera, score 7.2e-68 522373013220 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 522373013221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 522373013222 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.3e-05 522373013223 HMMPfam hit to PF01593, Flavin containing amine oxidoreductase, score 0.00075 522373013224 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 522373013225 HMMPfam hit to PF01694, Rhomboid family, score 2.1e-41 522373013226 5 probable transmembrane helices predicted for Smlt3453 by TMHMM2.0 at aa 31-53, 66-88, 93-112, 119-141 and 151-170 522373013227 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 522373013228 active site 522373013229 DNA binding site [nucleotide binding] 522373013230 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransferase, score 1.4e-07 522373013231 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 522373013232 EamA-like transporter family; Region: EamA; pfam00892 522373013233 EamA-like transporter family; Region: EamA; pfam00892 522373013234 HMMPfam hit to PF03151, Triose-phosphate Transporter family, score 0.0021 522373013235 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.9e-20 522373013236 9 probable transmembrane helices predicted for Smlt3455 by TMHMM2.0 at aa 15-37, 50-69, 108-130, 137-154, 164-186, 193-215, 230-252, 259-278 and 283-302 522373013237 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 8.5e-14 522373013238 glutathione reductase; Validated; Region: PRK06116 522373013239 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373013240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373013241 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 522373013242 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 8.1e-42 522373013243 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0016 522373013244 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 7.3e-49 522373013245 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 5.7e-21 522373013246 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 522373013247 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 6.7e-77 522373013248 1 probable transmembrane helix predicted for Smlt3457 by TMHMM2.0 at aa 7-24 522373013249 Predicted membrane protein [Function unknown]; Region: COG2311 522373013250 Protein of unknown function (DUF418); Region: DUF418; pfam04235 522373013251 HMMPfam hit to PF04235, Protein of unknown function (DUF418), score 5.1e-44 522373013252 8 probable transmembrane helices predicted for Smlt3458 by TMHMM2.0 at aa 34-56, 76-98, 119-141, 156-178, 260-282, 297-319, 328-350 and 365-384 522373013253 HMMPfam hit to PF04171, Protein of unknown function (DUF405), score 7.5e-56 522373013254 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 522373013255 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 522373013256 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 1.3e-07 522373013257 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 522373013258 NlpC/P60 family; Region: NLPC_P60; pfam00877 522373013259 HMMPfam hit to PF00877, NlpC/P60 family, score 1.4e-47 522373013260 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 522373013261 NlpC/P60 family; Region: NLPC_P60; pfam00877 522373013262 HMMPfam hit to PF00877, NlpC/P60 family, score 9.2e-45 522373013263 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 522373013264 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 522373013265 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 1.1e-82 522373013266 10 probable transmembrane helices predicted for Smlt3462 by TMHMM2.0 at aa 54-76, 86-108, 120-142, 195-217, 243-265, 275-294, 307-329, 349-371, 383-402 and 406-428 522373013267 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 522373013268 Alkaline phosphatase homologues; Region: alkPPc; smart00098 522373013269 active site 522373013270 dimer interface [polypeptide binding]; other site 522373013271 HMMPfam hit to PF00245, Alkaline phosphatase, score 3.8e-88 522373013272 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 522373013273 Ligand Binding Site [chemical binding]; other site 522373013274 TilS substrate binding domain; Region: TilS; pfam09179 522373013275 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 522373013276 HMMPfam hit to PF01171, PP-loop family, score 1.9e-76 522373013277 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 522373013278 HMMPfam hit to PF02609, Exonuclease VII small subunit, score 1.2e-24 522373013279 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 522373013280 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 522373013281 substrate binding pocket [chemical binding]; other site 522373013282 chain length determination region; other site 522373013283 substrate-Mg2+ binding site; other site 522373013284 catalytic residues [active] 522373013285 aspartate-rich region 1; other site 522373013286 active site lid residues [active] 522373013287 aspartate-rich region 2; other site 522373013288 HMMPfam hit to PF00348, Polyprenyl synthetase, score 6.7e-98 522373013289 Tic20-like protein; Region: Tic20; pfam09685 522373013290 3 probable transmembrane helices predicted for Smlt3468 by TMHMM2.0 at aa 38-60, 77-99 and 103-120 522373013291 peptidase PmbA; Provisional; Region: PRK11040 522373013292 HMMPfam hit to PF01523, Putative modulator of DNA gyrase, score 9.5e-54 522373013293 hypothetical protein; Provisional; Region: PRK05255 522373013294 HMMPfam hit to PF04751, Protein of unknown function (DUF615), score 1.6e-56 522373013295 protease TldD; Provisional; Region: tldD; PRK10735 522373013296 HMMPfam hit to PF01523, Putative modulator of DNA gyrase, score 2.7e-85 522373013297 TIGR02099 family protein; Region: TIGR02099 522373013298 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 522373013299 1 probable transmembrane helix predicted for Smlt3472 by TMHMM2.0 at aa 16-38 522373013300 ribonuclease G; Provisional; Region: PRK11712 522373013301 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 522373013302 homodimer interface [polypeptide binding]; other site 522373013303 oligonucleotide binding site [chemical binding]; other site 522373013304 HMMPfam hit to PF00575, S1 RNA binding domain, score 0.0022 522373013305 Maf-like protein; Region: Maf; pfam02545 522373013306 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 522373013307 active site 522373013308 dimer interface [polypeptide binding]; other site 522373013309 HMMPfam hit to PF02545, Maf-like protein, score 5.8e-61 522373013310 Uncharacterized conserved protein [Function unknown]; Region: COG2968 522373013311 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 522373013312 HMMPfam hit to PF04402, Protein of unknown function (DUF541), score 9.7e-81 522373013313 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373013314 1 probable transmembrane helix predicted for Smlt3477 by TMHMM2.0 at aa 28-50 522373013315 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 2.7e-07 522373013316 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 522373013317 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 522373013318 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373013319 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373013320 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 9.1e-22 522373013321 HMMPfam hit to PF00593, TonB dependent receptor, score 2.4e-30 522373013322 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 522373013323 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 522373013324 HMMPfam hit to PF03845, Spore germination protein, score 0.00064 522373013325 13 probable transmembrane helices predicted for Smlt3479 by TMHMM2.0 at aa 33-52, 67-89, 110-132, 152-169, 176-198, 222-244, 257-279, 303-325, 351-373, 378-400, 421-438, 443-462 and 474-491 522373013326 HMMPfam hit to PF00324, Amino acid permease, score 3e-05 522373013327 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 522373013328 HMMPfam hit to PF02590, Uncharacterized ACR, COG1576, score 1e-81 522373013329 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 522373013330 HMMPfam hit to PF02410, Domain of unknown function DUF143, score 1e-43 522373013331 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 522373013332 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 522373013333 active site 522373013334 (T/H)XGH motif; other site 522373013335 HMMPfam hit to PF01467, Cytidylyltransferase, score 5.9e-32 522373013336 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 522373013337 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 522373013338 HMMPfam hit to PF06144, DNA polymerase III, delta subunit, score 4.2e-26 522373013339 Lipopolysaccharide-assembly; Region: LptE; cl01125 522373013340 HMMPfam hit to PF04390, Rare lipoprotein B family, score 8.5e-41 522373013341 1 probable transmembrane helix predicted for Smlt3484 by TMHMM2.0 at aa 4-21 522373013342 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 522373013343 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 522373013344 HIGH motif; other site 522373013345 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 522373013346 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 522373013347 active site 522373013348 KMSKS motif; other site 522373013349 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 522373013350 tRNA binding surface [nucleotide binding]; other site 522373013351 HMMPfam hit to PF08264, Anticodon-binding domain, score 6.7e-07 522373013352 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 2.1e-14 522373013353 Protein of unknown function (DUF998); Region: DUF998; pfam06197 522373013354 5 probable transmembrane helices predicted for Smlt3486 by TMHMM2.0 at aa 28-50, 63-85, 100-122, 131-153 and 158-177 522373013355 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 522373013356 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 522373013357 catalytic residues [active] 522373013358 HMMPfam hit to PF00085, Thioredoxin, score 4.3e-37 522373013359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 522373013360 FecR protein; Region: FecR; pfam04773 522373013361 1 probable transmembrane helix predicted for Smlt3488 by TMHMM2.0 at aa 7-29 522373013362 HMMPfam hit to PF01476, LysM domain, score 3.7e-09 522373013363 CHASE2 domain; Region: CHASE2; pfam05226 522373013364 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373013365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373013366 metal binding site [ion binding]; metal-binding site 522373013367 active site 522373013368 I-site; other site 522373013369 3 probable transmembrane helices predicted for Smlt3489 by TMHMM2.0 at aa 13-32, 304-326 and 346-368 522373013370 HMMPfam hit to PF05226, CHASE2 domain, score 1.1e-37 522373013371 HMMPfam hit to PF00990, GGDEF domain, score 1.1e-56 522373013372 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 522373013373 1 probable transmembrane helix predicted for Smlt3491 by TMHMM2.0 at aa 7-29 522373013374 Uncharacterized conserved protein [Function unknown]; Region: COG2928 522373013375 2 probable transmembrane helices predicted for Smlt3492 by TMHMM2.0 at aa 21-43 and 71-93 522373013376 HMMPfam hit to PF04367, Protein of unknown function (DUF502), score 3.3e-64 522373013377 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 522373013378 6 probable transmembrane helices predicted for Smlt3493 by TMHMM2.0 at aa 13-35, 55-77, 90-112, 134-156, 177-199 and 214-236 522373013379 HMMPfam hit to PF02592, Uncharacterized ACR, YhhQ family COG1738, score 6.3e-23 522373013380 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 522373013381 HMMPfam hit to PF05960, Bacterial protein of unknown function (DUF88, score 3.1e-228 522373013382 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373013383 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373013384 1 probable transmembrane helix predicted for Smlt3495 by TMHMM2.0 at aa 5-27 522373013385 HMMPfam hit to PF00144, Beta-lactamase, score 2.7e-80 522373013386 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 522373013387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373013388 putative metal binding site [ion binding]; other site 522373013389 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 1.1e-28 522373013390 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 522373013391 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 522373013392 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 522373013393 active site 522373013394 HIGH motif; other site 522373013395 KMSKS motif; other site 522373013396 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 522373013397 anticodon binding site; other site 522373013398 tRNA binding surface [nucleotide binding]; other site 522373013399 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 522373013400 putative tRNA-binding site [nucleotide binding]; other site 522373013401 HMMPfam hit to PF01588, Putative tRNA binding domain, score 4.1e-30 522373013402 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 522373013403 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 522373013404 ferredoxin; Provisional; Region: PRK08764 522373013405 Putative Fe-S cluster; Region: FeS; pfam04060 522373013406 HMMPfam hit to PF04060, Putative Fe-S cluster, score 4.8e-19 522373013407 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 8.6e-06 522373013408 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 3.6e-05 522373013409 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 522373013410 homotrimer interaction site [polypeptide binding]; other site 522373013411 putative active site [active] 522373013412 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 9.8e-27 522373013413 Predicted integral membrane protein [Function unknown]; Region: COG0392 522373013414 Uncharacterized conserved protein [Function unknown]; Region: COG2898 522373013415 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 522373013416 13 probable transmembrane helices predicted for Smlt3502 by TMHMM2.0 at aa 20-37, 60-82, 94-116, 131-153, 174-193, 213-235, 247-269, 292-314, 335-357, 372-394, 415-437, 457-479 and 499-518 522373013417 HMMPfam hit to PF04329, Family of unknown function (DUF470), score 7.7e-58 522373013418 HMMPfam hit to PF04330, Family of unknown function (DUF471), score 2e-22 522373013419 HMMPfam hit to PF04331, Family of unknown function (DUF472), score 4.3e-49 522373013420 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 522373013421 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 522373013422 HMMPfam hit to PF06057, Bacterial virulence protein (VirJ), score 1.6e-98 522373013423 1 probable transmembrane helix predicted for Smlt3503 by TMHMM2.0 at aa 23-45 522373013424 Protein of unknown function (DUF998); Region: DUF998; pfam06197 522373013425 6 probable transmembrane helices predicted for Smlt3504 by TMHMM2.0 at aa 7-28, 48-70, 79-98, 113-135, 147-169 and 179-196 522373013426 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 522373013427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 522373013428 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 522373013429 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 522373013430 TPR repeat; Region: TPR_11; pfam13414 522373013431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373013432 binding surface 522373013433 TPR motif; other site 522373013434 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.52 522373013435 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.0048 522373013436 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 8.1e-06 522373013437 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 522373013438 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 522373013439 PhnA protein; Region: PhnA; pfam03831 522373013440 HMMPfam hit to PF03831, PhnA protein, score 1.6e-28 522373013441 HMMPfam hit to PF08274, PhnA Zinc-Ribbon, score 9.1e-13 522373013442 putative chaperone; Provisional; Region: PRK11678 522373013443 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 522373013444 nucleotide binding site [chemical binding]; other site 522373013445 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 522373013446 putative NEF/HSP70 interaction site [polypeptide binding]; other site 522373013447 nucleotide binding site [chemical binding]; other site 522373013448 SBD interface [polypeptide binding]; other site 522373013449 Flagellin N-methylase; Region: FliB; pfam03692 522373013450 HMMPfam hit to PF03692, Uncharacterised protein family (UPF0153), score 9.3e-05 522373013451 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 522373013452 Uncharacterized conserved protein [Function unknown]; Region: COG3595 522373013453 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 522373013454 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 522373013455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373013456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373013457 DNA binding residues [nucleotide binding] 522373013458 HMMPfam hit to PF04545, Sigma-70, region, score 1.8e-10 522373013459 HMMPfam hit to PF08281, Sigma-70, region, score 2.9e-18 522373013460 HMMPfam hit to PF04542, Sigma-70 region, score 9.4e-17 522373013461 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 522373013462 Mechanosensitive ion channel; Region: MS_channel; pfam00924 522373013463 3 probable transmembrane helices predicted for Smlt3515 by TMHMM2.0 at aa 15-37, 66-88 and 98-120 522373013464 hypothetical protein; Provisional; Region: PRK11019 522373013465 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 5.3e-19 522373013466 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 522373013467 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 522373013468 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 7.8e-06 522373013469 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 522373013470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373013471 RNA binding surface [nucleotide binding]; other site 522373013472 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 522373013473 active site 522373013474 HMMPfam hit to PF01479, S4 domain, score 9e-08 522373013475 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 522373013476 PLD-like domain; Region: PLDc_2; pfam13091 522373013477 putative active site [active] 522373013478 catalytic site [active] 522373013479 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 522373013480 PLD-like domain; Region: PLDc_2; pfam13091 522373013481 putative active site [active] 522373013482 catalytic site [active] 522373013483 1 probable transmembrane helix predicted for Smlt3521 by TMHMM2.0 at aa 19-41 522373013484 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.00012 522373013485 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 6e-07 522373013486 HDOD domain; Region: HDOD; pfam08668 522373013487 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 522373013488 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 522373013489 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 522373013490 NAD binding site [chemical binding]; other site 522373013491 Phe binding site; other site 522373013492 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimeri, score 1.4e-57 522373013493 HMMPfam hit to PF00208, Glutamate/Leucine/Phenylalanine/Valin, score 4.9e-39 522373013494 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 522373013495 catalytic triad [active] 522373013496 putative active site [active] 522373013497 Autotransporter beta-domain; Region: Autotransporter; smart00869 522373013498 HMMPfam hit to PF03797, Autotransporter beta-domain, score 6.3e-14 522373013499 HMMPfam hit to PF00082, Subtilase family, score 9.9e-25 522373013500 putative acyltransferase; Provisional; Region: PRK05790 522373013501 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 522373013502 dimer interface [polypeptide binding]; other site 522373013503 active site 522373013504 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 6.8e-116 522373013505 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 7.6e-60 522373013506 HMMPfam hit to PF02987, no description, score 0.51 522373013507 HMMPfam hit to PF02987, no description, score 0.0059 522373013508 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 522373013509 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 522373013510 active site 522373013511 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 2.4e-30 522373013512 HMMPfam hit to PF08028, Acyl-CoA dehydrogenase, C-terminal doma, score 0.0022 522373013513 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 1e-16 522373013514 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 522373013515 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 522373013516 ATP-dependent DNA ligase; Validated; Region: PRK09247 522373013517 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 522373013518 active site 522373013519 DNA binding site [nucleotide binding] 522373013520 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 522373013521 DNA binding site [nucleotide binding] 522373013522 HMMPfam hit to PF01068, ATP dependent DNA ligase domain, score 2e-30 522373013523 HMMPfam hit to PF04679, ATP dependent DNA ligase C terminal re, score 0.00025 522373013524 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 522373013525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373013526 ATP binding site [chemical binding]; other site 522373013527 putative Mg++ binding site [ion binding]; other site 522373013528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373013529 nucleotide binding region [chemical binding]; other site 522373013530 DEAD/H associated; Region: DEAD_assoc; pfam08494 522373013531 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.5e-23 522373013532 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 5.9e-13 522373013533 HMMPfam hit to PF08494, DEAD/H associated, score 3.9e-54 522373013534 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 522373013535 active site 522373013536 metal binding site [ion binding]; metal-binding site 522373013537 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 0.00091 522373013538 hypothetical protein; Provisional; Region: PRK07236 522373013539 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 522373013540 HMMPfam hit to PF01494, FAD binding domain, score 6.5e-08 522373013541 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 522373013542 DNA-binding site [nucleotide binding]; DNA binding site 522373013543 RNA-binding motif; other site 522373013544 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 3e-42 522373013545 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 522373013546 HMMPfam hit to PF00896, Phosphorylase family, score 3e-66 522373013547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 522373013548 active site 522373013549 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 7.2e-18 522373013550 beta-hexosaminidase; Provisional; Region: PRK05337 522373013551 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 522373013552 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N terminal, score 1.9e-67 522373013553 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 522373013554 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 522373013555 catalytic residues [active] 522373013556 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 5.8e-38 522373013557 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 522373013558 putative active site [active] 522373013559 putative metal binding residues [ion binding]; other site 522373013560 signature motif; other site 522373013561 putative dimer interface [polypeptide binding]; other site 522373013562 putative phosphate binding site [ion binding]; other site 522373013563 HMMPfam hit to PF01928, CYTH domain, score 1e-30 522373013564 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 522373013565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373013566 S-adenosylmethionine binding site [chemical binding]; other site 522373013567 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 1e-08 522373013568 HMMPfam hit to PF01938, TRAM domain, score 0.031 522373013569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373013570 Response regulator receiver domain; Region: Response_reg; pfam00072 522373013571 active site 522373013572 phosphorylation site [posttranslational modification] 522373013573 intermolecular recognition site; other site 522373013574 dimerization interface [polypeptide binding]; other site 522373013575 Hpt domain; Region: Hpt; pfam01627 522373013576 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-24 522373013577 HMMPfam hit to PF01627, Hpt domain, score 1.4e-10 522373013578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 522373013579 Transposase; Region: HTH_Tnp_1; cl17663 522373013580 HMMPfam hit to PF01527, Transposase, score 0.00054 522373013581 putative transposase OrfB; Reviewed; Region: PHA02517 522373013582 HTH-like domain; Region: HTH_21; pfam13276 522373013583 Integrase core domain; Region: rve; pfam00665 522373013584 Integrase core domain; Region: rve_2; pfam13333 522373013585 HMMPfam hit to PF00665, Integrase core domain, score 4.2e-43 522373013586 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 522373013587 Recombination protein O N terminal; Region: RecO_N; pfam11967 522373013588 Recombination protein O C terminal; Region: RecO_C; pfam02565 522373013589 HMMPfam hit to PF02565, Recombination protein O, score 1.1e-06 522373013590 GTPase Era; Reviewed; Region: era; PRK00089 522373013591 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 522373013592 G1 box; other site 522373013593 GTP/Mg2+ binding site [chemical binding]; other site 522373013594 Switch I region; other site 522373013595 G2 box; other site 522373013596 Switch II region; other site 522373013597 G3 box; other site 522373013598 G4 box; other site 522373013599 G5 box; other site 522373013600 KH domain; Region: KH_2; pfam07650 522373013601 HMMPfam hit to PF07650, KH domain, score 2.7e-26 522373013602 HMMPfam hit to PF01926, GTPase of unknown function, score 3.3e-38 522373013603 ribonuclease III; Reviewed; Region: rnc; PRK00102 522373013604 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 522373013605 dimerization interface [polypeptide binding]; other site 522373013606 active site 522373013607 metal binding site [ion binding]; metal-binding site 522373013608 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 522373013609 dsRNA binding site [nucleotide binding]; other site 522373013610 HMMPfam hit to PF00035, Double-stranded RNA binding motif, score 8.1e-15 522373013611 HMMPfam hit to PF00636, RNase3 domain, score 1.3e-41 522373013612 1 probable transmembrane helix predicted for Smlt3550 by TMHMM2.0 at aa 42-61 522373013613 signal peptidase I; Provisional; Region: PRK10861 522373013614 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 522373013615 Catalytic site [active] 522373013616 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 522373013617 HMMPfam hit to PF00717, Peptidase S24-like, score 3.3e-25 522373013618 2 probable transmembrane helices predicted for Smlt3551 by TMHMM2.0 at aa 4-26 and 46-65 522373013619 GTP-binding protein LepA; Provisional; Region: PRK05433 522373013620 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 522373013621 G1 box; other site 522373013622 putative GEF interaction site [polypeptide binding]; other site 522373013623 GTP/Mg2+ binding site [chemical binding]; other site 522373013624 Switch I region; other site 522373013625 G2 box; other site 522373013626 G3 box; other site 522373013627 Switch II region; other site 522373013628 G4 box; other site 522373013629 G5 box; other site 522373013630 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 522373013631 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 522373013632 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 522373013633 HMMPfam hit to PF06421, GTP-binding protein LepA C-terminus, score 5.7e-85 522373013634 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 2.2e-33 522373013635 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1e-08 522373013636 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3e-73 522373013637 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 522373013638 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 522373013639 active site 522373013640 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 522373013641 protein binding site [polypeptide binding]; other site 522373013642 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 522373013643 protein binding site [polypeptide binding]; other site 522373013644 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 8.7e-12 522373013645 HMMPfam hit to PF00089, Trypsin, score 1.1e-18 522373013646 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 522373013647 1 probable transmembrane helix predicted for Smlt3554 by TMHMM2.0 at aa 106-128 522373013648 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 522373013649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373013650 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373013651 DNA binding residues [nucleotide binding] 522373013652 HMMPfam hit to PF04545, Sigma-70, region, score 3.7e-16 522373013653 HMMPfam hit to PF08281, Sigma-70, region, score 1.6e-20 522373013654 HMMPfam hit to PF04542, Sigma-70 region, score 2.2e-22 522373013655 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 522373013656 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 522373013657 substrate binding site [chemical binding]; other site 522373013658 oxyanion hole (OAH) forming residues; other site 522373013659 trimer interface [polypeptide binding]; other site 522373013660 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 522373013661 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 522373013662 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 522373013663 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 2.1e-53 522373013664 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 1.3e-56 522373013665 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 8.2e-22 522373013666 Pirin-related protein [General function prediction only]; Region: COG1741 522373013667 Pirin; Region: Pirin; pfam02678 522373013668 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 522373013669 HMMPfam hit to PF02678, Pirin, score 2.8e-55 522373013670 HMMPfam hit to PF05726, Pirin C-terminal cupin domain, score 3.3e-42 522373013671 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 522373013672 amphipathic channel; other site 522373013673 Asn-Pro-Ala signature motifs; other site 522373013674 HMMPfam hit to PF00230, Major intrinsic protein, score 9.1e-40 522373013675 6 probable transmembrane helices predicted for Smlt3559 by TMHMM2.0 at aa 7-29, 39-61, 87-109, 139-161, 168-190 and 214-236 522373013676 Pirin-related protein [General function prediction only]; Region: COG1741 522373013677 Pirin; Region: Pirin; pfam02678 522373013678 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 522373013679 HMMPfam hit to PF05726, Pirin C-terminal cupin domain, score 1.3e-43 522373013680 HMMPfam hit to PF02678, Pirin, score 5.8e-57 522373013681 carbon starvation protein A; Provisional; Region: PRK15015 522373013682 Carbon starvation protein CstA; Region: CstA; pfam02554 522373013683 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 522373013684 16 probable transmembrane helices predicted for Smlt3562 by TMHMM2.0 at aa 7-26, 31-53, 88-110, 115-137, 158-180, 190-212, 217-234, 254-276, 281-303, 323-345, 362-384, 466-485, 514-536, 546-568, 575-597 and 641-663 522373013685 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 3.4e-260 522373013686 Protein of unknown function (DUF466); Region: DUF466; pfam04328 522373013687 HMMPfam hit to PF04328, Protein of unknown function (DUF466), score 3.1e-26 522373013688 Protein of unknown function (DUF819); Region: DUF819; cl02317 522373013689 HMMPfam hit to PF05684, Protein of unknown function (DUF819), score 1.7e-164 522373013690 12 probable transmembrane helices predicted for Smlt3565 by TMHMM2.0 at aa 39-61, 71-93, 105-124, 134-156, 168-190, 200-222, 264-286, 301-320, 333-355, 360-379, 386-408 and 418-440 522373013691 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 522373013692 active site 522373013693 metal binding site [ion binding]; metal-binding site 522373013694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373013695 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 2.4e-10 522373013696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373013697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 522373013698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373013699 dimer interface [polypeptide binding]; other site 522373013700 phosphorylation site [posttranslational modification] 522373013701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373013702 ATP binding site [chemical binding]; other site 522373013703 Mg2+ binding site [ion binding]; other site 522373013704 G-X-G motif; other site 522373013705 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.7e-16 522373013706 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 5.9e-14 522373013707 HMMPfam hit to PF00672, HAMP domain, score 5.1e-07 522373013708 2 probable transmembrane helices predicted for Smlt3567 by TMHMM2.0 at aa 15-37 and 139-158 522373013709 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373013710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373013711 active site 522373013712 phosphorylation site [posttranslational modification] 522373013713 intermolecular recognition site; other site 522373013714 dimerization interface [polypeptide binding]; other site 522373013715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373013716 DNA binding site [nucleotide binding] 522373013717 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.8e-14 522373013718 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.2e-36 522373013719 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 522373013720 HMMPfam hit to PF02366, Dolichyl-phosphate-mannose-protein mannosylt, score 0.00053 522373013721 12 probable transmembrane helices predicted for Smlt3569 by TMHMM2.0 at aa 20-37, 89-111, 124-141, 148-165, 180-202, 223-245, 279-301, 317-334, 338-360, 367-386, 406-428 and 435-457 522373013722 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 522373013723 active site 522373013724 6 probable transmembrane helices predicted for Smlt3570 by TMHMM2.0 at aa 21-43, 79-96, 103-125, 161-183, 190-209 and 219-236 522373013725 HMMPfam hit to PF01569, PAP2 superfamily, score 0.0004 522373013726 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 522373013727 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 522373013728 Sulfatase; Region: Sulfatase; pfam00884 522373013729 5 probable transmembrane helices predicted for Smlt3571 by TMHMM2.0 at aa 28-50, 60-79, 86-108, 128-150 and 162-184 522373013730 HMMPfam hit to PF08019, Domain of unknown function (DUF1705), score 1.7e-55 522373013731 HMMPfam hit to PF00884, Sulfatase, score 1.1e-77 522373013732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 522373013733 Transposase; Region: DEDD_Tnp_IS110; pfam01548 522373013734 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 522373013735 HMMPfam hit to PF01548, Transposase, score 1.8e-06 522373013736 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 4.3e-27 522373013737 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 522373013738 active site 522373013739 Zn binding site [ion binding]; other site 522373013740 HMMPfam hit to PF01401, Angiotensin-converting enzyme, score 1.8e-153 522373013741 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 522373013742 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 522373013743 FAD binding pocket [chemical binding]; other site 522373013744 FAD binding motif [chemical binding]; other site 522373013745 phosphate binding motif [ion binding]; other site 522373013746 NAD binding pocket [chemical binding]; other site 522373013747 HMMPfam hit to PF04954, Siderophore-interacting protein, score 1.2e-38 522373013748 HMMPfam hit to PF08021, Siderophore-interacting FAD-binding dom, score 1.9e-53 522373013749 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 522373013750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373013751 putative substrate translocation pore; other site 522373013752 12 probable transmembrane helices predicted for Smlt3578 by TMHMM2.0 at aa 140-159, 174-193, 206-225, 230-252, 264-286, 290-309, 348-370, 380-399, 412-432, 442-464, 477-499 and 504-521 522373013753 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.7e-49 522373013754 glycine dehydrogenase; Provisional; Region: PRK05367 522373013755 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 522373013756 tetramer interface [polypeptide binding]; other site 522373013757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373013758 catalytic residue [active] 522373013759 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 522373013760 tetramer interface [polypeptide binding]; other site 522373013761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373013762 catalytic residue [active] 522373013763 HMMPfam hit to PF02347, Glycine cleavage system P-protein, score 2.3e-248 522373013764 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 522373013765 dimer interface [polypeptide binding]; other site 522373013766 HMMPfam hit to PF06983, 3-demethylubiquinone-9 3-methyltransfera, score 1.2e-29 522373013767 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 522373013768 HMMPfam hit to PF00324, Amino acid permease, score 5.8e-104 522373013769 13 probable transmembrane helices predicted for Smlt3581 by TMHMM2.0 at aa 59-81, 88-107, 122-141, 143-165, 169-186, 198-220, 240-262, 282-304, 324-346, 372-394, 398-420, 441-460 and 470-487 522373013770 PAS fold; Region: PAS_4; pfam08448 522373013771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373013772 putative active site [active] 522373013773 heme pocket [chemical binding]; other site 522373013774 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 522373013775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373013776 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.1e-11 522373013777 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.0011 522373013778 HMMPfam hit to PF08448, PAS fold, score 4.6e-27 522373013779 hydroperoxidase II; Provisional; Region: katE; PRK11249 522373013780 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 522373013781 heme binding pocket [chemical binding]; other site 522373013782 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 522373013783 domain interactions; other site 522373013784 HMMPfam hit to PF00199, Catalase, score 8.1e-256 522373013785 HMMPfam hit to PF06628, Catalase-related, score 1.1e-21 522373013786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373013787 2 probable transmembrane helices predicted for Smlt3587 by TMHMM2.0 at aa 12-34 and 73-95 522373013788 HAMP domain; Region: HAMP; pfam00672 522373013789 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 522373013790 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373013791 dimer interface [polypeptide binding]; other site 522373013792 putative CheW interface [polypeptide binding]; other site 522373013793 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2e-77 522373013794 HMMPfam hit to PF00672, HAMP domain, score 1.6e-12 522373013795 2 probable transmembrane helices predicted for Smlt3588 by TMHMM2.0 at aa 39-61 and 218-240 522373013796 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 522373013797 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 522373013798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 522373013799 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 522373013800 HMMPfam hit to PF01471, Putative peptidoglycan binding domain, score 2.5e-10 522373013801 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 9.6e-34 522373013802 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 522373013803 Peptidase family M23; Region: Peptidase_M23; pfam01551 522373013804 HMMPfam hit to PF01551, Peptidase family M23, score 1.4e-30 522373013805 2 probable transmembrane helices predicted for Smlt3591 by TMHMM2.0 at aa 41-63 and 208-230 522373013806 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 522373013807 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 522373013808 GDP-binding site [chemical binding]; other site 522373013809 ACT binding site; other site 522373013810 IMP binding site; other site 522373013811 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 2.8e-291 522373013812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 522373013813 2 probable transmembrane helices predicted for Smlt3594 by TMHMM2.0 at aa 15-37 and 49-71 522373013814 FtsH protease regulator HflC; Provisional; Region: PRK11029 522373013815 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 522373013816 HMMPfam hit to PF01145, SPFH domain / Band, score 1.2e-23 522373013817 1 probable transmembrane helix predicted for Smlt3595 by TMHMM2.0 at aa 5-24 522373013818 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 522373013819 HflK protein; Region: hflK; TIGR01933 522373013820 HMMPfam hit to PF01145, SPFH domain / Band, score 2.2e-32 522373013821 1 probable transmembrane helix predicted for Smlt3596 by TMHMM2.0 at aa 48-70 522373013822 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 522373013823 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 522373013824 NADP binding site [chemical binding]; other site 522373013825 dimer interface [polypeptide binding]; other site 522373013826 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 9.8e-07 522373013827 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 2.2e-07 522373013828 Response regulator receiver domain; Region: Response_reg; pfam00072 522373013829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373013830 active site 522373013831 phosphorylation site [posttranslational modification] 522373013832 intermolecular recognition site; other site 522373013833 dimerization interface [polypeptide binding]; other site 522373013834 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.9e-33 522373013835 chaperone protein DnaJ; Provisional; Region: PRK14299 522373013836 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 522373013837 HSP70 interaction site [polypeptide binding]; other site 522373013838 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 522373013839 substrate binding site [polypeptide binding]; other site 522373013840 dimer interface [polypeptide binding]; other site 522373013841 HMMPfam hit to PF01556, DnaJ C terminal region, score 1.2e-28 522373013842 HMMPfam hit to PF00226, DnaJ domain, score 4.5e-33 522373013843 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 522373013844 catalytic triad [active] 522373013845 dimer interface [polypeptide binding]; other site 522373013846 HMMPfam hit to PF00578, AhpC/TSA family, score 8.7e-06 522373013847 HMMPfam hit to PF08534, Redoxin, score 9e-43 522373013848 Ferritin-like domain; Region: Ferritin; pfam00210 522373013849 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 522373013850 dinuclear metal binding motif [ion binding]; other site 522373013851 HMMPfam hit to PF00210, Ferritin-like domain, score 1.4e-18 522373013852 HMMPfam hit to PF02915, Rubrerythrin, score 3.9e-05 522373013853 penicillin-binding protein 1C; Provisional; Region: PRK11240 522373013854 Transglycosylase; Region: Transgly; pfam00912 522373013855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 522373013856 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 522373013857 HMMPfam hit to PF06832, Penicillin-Binding Protein C-terminus, score 1.5e-25 522373013858 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 2.1e-08 522373013859 HMMPfam hit to PF00912, Transglycosylase, score 7.2e-82 522373013860 1 probable transmembrane helix predicted for Smlt3602 by TMHMM2.0 at aa 24-46 522373013861 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 522373013862 MG2 domain; Region: A2M_N; pfam01835 522373013863 Alpha-2-macroglobulin family; Region: A2M; pfam00207 522373013864 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 522373013865 surface patch; other site 522373013866 thioester region; other site 522373013867 specificity defining residues; other site 522373013868 HMMPfam hit to PF07703, Alpha-2-macroglobulin family N-terminal regi, score 3.4e-30 522373013869 HMMPfam hit to PF01835, Alpha-2-macroglobulin family N-terminal regi, score 6.8e-75 522373013870 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 522373013871 2-methylcitrate dehydratase; Region: prpD; TIGR02330 522373013872 HMMPfam hit to PF03972, MmgE/PrpD family, score 3.1e-209 522373013873 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 522373013874 HMMPfam hit to PF04303, Protein of unknown function (DUF453), score 4.9e-268 522373013875 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 522373013876 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 3.5e-06 522373013877 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 522373013878 HMMPfam hit to PF03693, Uncharacterised protein family (UPF0156), score 0.0049 522373013879 HMMPfam hit to PF01402, Ribbon-helix-helix protein, copG family, score 5.4e-05 522373013880 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 522373013881 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 522373013882 substrate binding site [chemical binding]; other site 522373013883 ligand binding site [chemical binding]; other site 522373013884 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 522373013885 substrate binding site [chemical binding]; other site 522373013886 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 4.6e-34 522373013887 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 7e-146 522373013888 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 522373013889 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 522373013890 dimer interface [polypeptide binding]; other site 522373013891 active site 522373013892 citrylCoA binding site [chemical binding]; other site 522373013893 oxalacetate/citrate binding site [chemical binding]; other site 522373013894 coenzyme A binding site [chemical binding]; other site 522373013895 catalytic triad [active] 522373013896 HMMPfam hit to PF00285, Citrate synthase, score 4e-101 522373013897 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 522373013898 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 522373013899 tetramer interface [polypeptide binding]; other site 522373013900 active site 522373013901 Mg2+/Mn2+ binding site [ion binding]; other site 522373013902 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 522373013903 Propionate catabolism activator; Region: PrpR_N; pfam06506 522373013904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373013905 Walker A motif; other site 522373013906 ATP binding site [chemical binding]; other site 522373013907 Walker B motif; other site 522373013908 HMMPfam hit to PF06506, Propionate catabolism activator, score 1.1e-89 522373013909 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.2e-123 522373013910 HMMPfam hit to PF07728, ATPase family associated with various, score 0.00069 522373013911 Predicted membrane protein [Function unknown]; Region: COG2259 522373013912 HMMPfam hit to PF07681, DoxX, score 6.4e-12 522373013913 4 probable transmembrane helices predicted for Smlt3613 by TMHMM2.0 at aa 46-68, 88-110, 115-137 and 147-169 522373013914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 522373013915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373013916 Coenzyme A binding pocket [chemical binding]; other site 522373013917 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1e-17 522373013918 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 522373013919 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 522373013920 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 522373013921 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 5e-21 522373013922 D-glycerate 3-kinase; Region: PLN02796 522373013923 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 522373013924 Dodecin; Region: Dodecin; pfam07311 522373013925 HMMPfam hit to PF07311, Protein of unknown function (DUF1458), score 5.6e-06 522373013926 shikimate kinase; Reviewed; Region: aroK; PRK00131 522373013927 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 522373013928 ADP binding site [chemical binding]; other site 522373013929 magnesium binding site [ion binding]; other site 522373013930 putative shikimate binding site; other site 522373013931 HMMPfam hit to PF01202, Shikimate kinase, score 1.5e-62 522373013932 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 522373013933 active site 522373013934 dimer interface [polypeptide binding]; other site 522373013935 metal binding site [ion binding]; metal-binding site 522373013936 HMMPfam hit to PF01761, 3-dehydroquinate synthase, score 2.4e-155 522373013937 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 522373013938 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 522373013939 substrate binding site [chemical binding]; other site 522373013940 active site 522373013941 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 2.2e-176 522373013942 putative transporter; Provisional; Region: PRK10504 522373013943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373013944 putative substrate translocation pore; other site 522373013945 14 probable transmembrane helices predicted for Smlt3623 by TMHMM2.0 at aa 24-46, 61-83, 92-111, 115-137, 150-172, 177-199, 212-229, 239-258, 265-287, 302-324, 344-362, 372-394, 406-428 and 443-465 522373013946 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.5e-56 522373013947 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 522373013948 Two component regulator propeller; Region: Reg_prop; pfam07494 522373013949 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 522373013950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373013951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373013952 dimer interface [polypeptide binding]; other site 522373013953 phosphorylation site [posttranslational modification] 522373013954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373013955 ATP binding site [chemical binding]; other site 522373013956 Mg2+ binding site [ion binding]; other site 522373013957 G-X-G motif; other site 522373013958 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373013959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373013960 active site 522373013961 phosphorylation site [posttranslational modification] 522373013962 intermolecular recognition site; other site 522373013963 dimerization interface [polypeptide binding]; other site 522373013964 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.6e-24 522373013965 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 8.4e-44 522373013966 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 9.7e-26 522373013967 1 probable transmembrane helix predicted for Smlt3625 by TMHMM2.0 at aa 754-776 522373013968 HMMPfam hit to PF07495, Y_Y_Y domain, score 4.6e-15 522373013969 HMMPfam hit to PF07494, Two component regulator propeller, score 9.9 522373013970 HMMPfam hit to PF07494, Two component regulator propeller, score 11 522373013971 HMMPfam hit to PF07494, Two component regulator propeller, score 47 522373013972 HMMPfam hit to PF07494, Two component regulator propeller, score 30 522373013973 HMMPfam hit to PF07494, Two component regulator propeller, score 35 522373013974 HMMPfam hit to PF07494, Two component regulator propeller, score 54 522373013975 HMMPfam hit to PF07494, Two component regulator propeller, score 36 522373013976 HMMPfam hit to PF07494, Two component regulator propeller, score 46 522373013977 HMMPfam hit to PF07494, Two component regulator propeller, score 11 522373013978 HMMPfam hit to PF07494, Two component regulator propeller, score 0.39 522373013979 HMMPfam hit to PF07494, Two component regulator propeller, score 0.13 522373013980 HMMPfam hit to PF07494, Two component regulator propeller, score 0.086 522373013981 HMMPfam hit to PF07494, Two component regulator propeller, score 0.0019 522373013982 putative sensor histidine kinase/response regulator fusion protein, pseudogene;similarity:fasta; CAM0227; bcenocepacia; putative histidine kinase/response regulator fusion protein; length 1011 aa; id=38.8%; E()=8.5e-34; 387 aa overlap; query 807-1174 aa; subject 523-907 aa 522373013983 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.6e-23 522373013984 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 3.6e-44 522373013985 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.0023 522373013986 2 probable transmembrane helices predicted for Smlt3626 by TMHMM2.0 at aa 7-29 and 765-787 522373013987 HMMPfam hit to PF07495, Y_Y_Y domain, score 1.1e-11 522373013988 HMMPfam hit to PF07494, Two component regulator propeller, score 5.3 522373013989 HMMPfam hit to PF07494, Two component regulator propeller, score 39 522373013990 HMMPfam hit to PF07494, Two component regulator propeller, score 30 522373013991 HMMPfam hit to PF07494, Two component regulator propeller, score 19 522373013992 HMMPfam hit to PF07494, Two component regulator propeller, score 0.31 522373013993 HMMPfam hit to PF07494, Two component regulator propeller, score 0.0091 522373013994 HMMPfam hit to PF07494, Two component regulator propeller, score 40 522373013995 HMMPfam hit to PF07494, Two component regulator propeller, score 3 522373013996 HMMPfam hit to PF07494, Two component regulator propeller, score 0.052 522373013997 Uncharacterized conserved protein [Function unknown]; Region: COG2353 522373013998 HMMPfam hit to PF04264, YceI like family, score 4.1e-53 522373013999 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 522373014000 HMMPfam hit to PF01292, Cytochrome b561 family, score 5.6e-66 522373014001 4 probable transmembrane helices predicted for Smlt3628 by TMHMM2.0 at aa 13-35, 45-67, 88-110 and 147-169 522373014002 Uncharacterized conserved protein [Function unknown]; Region: COG2353 522373014003 HMMPfam hit to PF04264, YceI like family, score 1.1e-47 522373014004 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 522373014005 HMMPfam hit to PF05768, Glutaredoxin-like domain (DUF836), score 1.7e-16 522373014006 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 522373014007 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 522373014008 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 522373014009 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 2.2e-35 522373014010 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 3.4e-174 522373014011 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 522373014012 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 522373014013 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 6.9e-20 522373014014 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 522373014015 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 522373014016 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 522373014017 HMMPfam hit to PF00742, Homoserine dehydrogenase, score 9.5e-57 522373014018 HMMPfam hit to PF03447, Homoserine dehydrogenase, NAD binding d, score 0.0011 522373014019 cystathionine gamma-synthase; Provisional; Region: PRK08776 522373014020 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 522373014021 homodimer interface [polypeptide binding]; other site 522373014022 substrate-cofactor binding pocket; other site 522373014023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373014024 catalytic residue [active] 522373014025 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 3.6e-179 522373014026 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.0013 522373014027 homoserine O-acetyltransferase; Provisional; Region: PRK08775 522373014028 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 522373014029 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 2e-12 522373014030 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 522373014031 Peptidase family M23; Region: Peptidase_M23; pfam01551 522373014032 HMMPfam hit to PF01551, Peptidase family M23, score 2e-25 522373014033 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 522373014034 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 522373014035 G1 box; other site 522373014036 putative GEF interaction site [polypeptide binding]; other site 522373014037 GTP/Mg2+ binding site [chemical binding]; other site 522373014038 Switch I region; other site 522373014039 G2 box; other site 522373014040 G3 box; other site 522373014041 Switch II region; other site 522373014042 G4 box; other site 522373014043 G5 box; other site 522373014044 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 522373014045 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3.9e-60 522373014046 HMMPfam hit to PF03144, Elongation factor Tu domain, score 3e-06 522373014047 Haemolysin-III related; Region: HlyIII; cl03831 522373014048 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 522373014049 HMMPfam hit to PF03006, Haemolysin-III related, score 1.1e-68 522373014050 7 probable transmembrane helices predicted for Smlt3638 by TMHMM2.0 at aa 31-53, 58-80, 92-114, 118-140, 147-169, 173-192 and 197-219 522373014051 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 522373014052 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 522373014053 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 522373014054 HMMPfam hit to PF05170, AsmA family, score 1.3e-50 522373014055 1 probable transmembrane helix predicted for Smlt3639 by TMHMM2.0 at aa 27-49 522373014056 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 522373014057 HMMPfam hit to PF00571, CBS domain pair, score 6.2e-17 522373014058 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 522373014059 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 522373014060 Ligand binding site; other site 522373014061 Putative Catalytic site; other site 522373014062 DXD motif; other site 522373014063 2 probable transmembrane helices predicted for Smlt3641 by TMHMM2.0 at aa 234-253 and 268-290 522373014064 HMMPfam hit to PF00535, Glycosyl transferase family, score 5.1e-20 522373014065 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 522373014066 Transglycosylase; Region: Transgly; cl17702 522373014067 HMMPfam hit to PF00912, Transglycosylase, score 1.3e-72 522373014068 1 probable transmembrane helix predicted for Smlt3642 by TMHMM2.0 at aa 27-49 522373014069 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 522373014070 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 522373014071 dimerization interface [polypeptide binding]; other site 522373014072 domain crossover interface; other site 522373014073 redox-dependent activation switch; other site 522373014074 HMMPfam hit to PF01430, Hsp33 protein, score 2.1e-65 522373014075 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 522373014076 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373014077 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373014078 HMMPfam hit to PF00593, TonB dependent receptor, score 3.1e-16 522373014079 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1e-20 522373014080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373014081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373014082 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2.5e-13 522373014083 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 522373014084 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373014085 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.3e-08 522373014086 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 522373014087 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 522373014088 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 522373014089 active site 522373014090 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 522373014091 3 probable transmembrane helices predicted for Smlt3648 by TMHMM2.0 at aa 2-19, 24-43 and 50-68 522373014092 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 2e-06 522373014093 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 1.3e-14 522373014094 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 522373014095 CoenzymeA binding site [chemical binding]; other site 522373014096 subunit interaction site [polypeptide binding]; other site 522373014097 PHB binding site; other site 522373014098 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 522373014099 HMMPfam hit to PF06993, Protein of unknown function (DUF1304), score 3.7e-54 522373014100 3 probable transmembrane helices predicted for Smlt3650 by TMHMM2.0 at aa 5-27, 48-70 and 74-93 522373014101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373014102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373014103 TLC ATP/ADP transporter; Region: TLC; cl03940 522373014104 11 probable transmembrane helices predicted for Smlt3651 by TMHMM2.0 at aa 49-68, 81-100, 105-127, 134-154, 164-183, 196-218, 222-244, 284-306, 326-345, 352-374 and 438-460 522373014105 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373014106 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373014107 HMMPfam hit to PF00144, Beta-lactamase, score 6.7e-81 522373014108 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 522373014109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373014110 NAD(P) binding site [chemical binding]; other site 522373014111 active site 522373014112 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.0033 522373014113 HMMPfam hit to PF00106, short chain dehydrogenase, score 3.2e-21 522373014114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373014115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373014116 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 522373014117 putative effector binding pocket; other site 522373014118 putative dimerization interface [polypeptide binding]; other site 522373014119 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6e-11 522373014120 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-50 522373014121 glycine cleavage system protein H; Provisional; Region: PRK13380 522373014122 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 522373014123 lipoyl attachment site [posttranslational modification]; other site 522373014124 HMMPfam hit to PF01597, Glycine cleavage H-protein, score 4.5e-65 522373014125 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 522373014126 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 522373014127 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 6.2e-133 522373014128 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 522373014129 HMMPfam hit to PF01957, Nodulation efficiency protein D (NfeD), score 9.5e-40 522373014130 2 probable transmembrane helices predicted for Smlt3659 by TMHMM2.0 at aa 5-27 and 37-59 522373014131 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 522373014132 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 522373014133 HMMPfam hit to PF01145, SPFH domain / Band, score 6.5e-77 522373014134 2 probable transmembrane helices predicted for Smlt3660 by TMHMM2.0 at aa 4-23 and 36-58 522373014135 Protein of unknown function (DUF962); Region: DUF962; pfam06127 522373014136 2 probable transmembrane helices predicted for Smlt3661 by TMHMM2.0 at aa 40-57 and 62-82 522373014137 hypothetical protein; Provisional; Region: PRK02237 522373014138 HMMPfam hit to PF02694, Uncharacterised BCR, YnfA/UPF0060 family, score 4.6e-57 522373014139 4 probable transmembrane helices predicted for Smlt3662 by TMHMM2.0 at aa 13-35, 39-61, 68-87 and 97-114 522373014140 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 522373014141 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 522373014142 homodimer interface [polypeptide binding]; other site 522373014143 metal binding site [ion binding]; metal-binding site 522373014144 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 522373014145 homodimer interface [polypeptide binding]; other site 522373014146 active site 522373014147 putative chemical substrate binding site [chemical binding]; other site 522373014148 metal binding site [ion binding]; metal-binding site 522373014149 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 5.4e-07 522373014150 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 1.2e-44 522373014151 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 522373014152 active site 522373014153 HMMPfam hit to PF00459, Inositol monophosphatase family, score 5.1e-55 522373014154 1 probable transmembrane helix predicted for Smlt3664 by TMHMM2.0 at aa 114-136 522373014155 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 522373014156 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 522373014157 dimer interface [polypeptide binding]; other site 522373014158 ADP-ribose binding site [chemical binding]; other site 522373014159 active site 522373014160 nudix motif; other site 522373014161 metal binding site [ion binding]; metal-binding site 522373014162 HMMPfam hit to PF00293, NUDIX domain, score 9.5e-13 522373014163 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK08742 522373014164 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 522373014165 inhibitor-cofactor binding pocket; inhibition site 522373014166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373014167 catalytic residue [active] 522373014168 HMMPfam hit to PF00202, Aminotransferase class-III, score 7.8e-128 522373014169 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 522373014170 HMMPfam hit to PF04452, Protein of unknown function (DUF558), score 8.7e-100 522373014171 CheW-like domain; Region: CheW; pfam01584 522373014172 HMMPfam hit to PF01584, CheW-like domain, score 2e-21 522373014173 CheB methylesterase; Region: CheB_methylest; pfam01339 522373014174 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 522373014175 putative binding surface; other site 522373014176 active site 522373014177 Hpt domain; Region: Hpt; pfam01627 522373014178 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 522373014179 putative binding surface; other site 522373014180 active site 522373014181 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 522373014182 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 522373014183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373014184 ATP binding site [chemical binding]; other site 522373014185 Mg2+ binding site [ion binding]; other site 522373014186 G-X-G motif; other site 522373014187 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 522373014188 Response regulator receiver domain; Region: Response_reg; pfam00072 522373014189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373014190 active site 522373014191 phosphorylation site [posttranslational modification] 522373014192 intermolecular recognition site; other site 522373014193 dimerization interface [polypeptide binding]; other site 522373014194 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.4e-34 522373014195 HMMPfam hit to PF01584, CheW-like domain, score 5.3e-25 522373014196 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 3.4e-22 522373014197 HMMPfam hit to PF02895, Signal transducing histidine kinase, hom, score 0.00037 522373014198 HMMPfam hit to PF01627, Hpt domain, score 1.1e-13 522373014199 HMMPfam hit to PF01627, Hpt domain, score 6.8e-15 522373014200 HMMPfam hit to PF01627, Hpt domain, score 7.2e-14 522373014201 HMMPfam hit to PF01627, Hpt domain, score 1.1e-10 522373014202 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 522373014203 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373014204 dimer interface [polypeptide binding]; other site 522373014205 putative CheW interface [polypeptide binding]; other site 522373014206 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.9e-52 522373014207 1 probable transmembrane helix predicted for Smlt3671 by TMHMM2.0 at aa 279-301 522373014208 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 522373014209 HMMPfam hit to PF01584, CheW-like domain, score 6.6e-26 522373014210 Response regulator receiver domain; Region: Response_reg; pfam00072 522373014211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373014212 active site 522373014213 phosphorylation site [posttranslational modification] 522373014214 intermolecular recognition site; other site 522373014215 dimerization interface [polypeptide binding]; other site 522373014216 HMMPfam hit to PF00072, Response regulator receiver domain, score 9.8e-32 522373014217 Response regulator receiver domain; Region: Response_reg; pfam00072 522373014218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373014219 active site 522373014220 phosphorylation site [posttranslational modification] 522373014221 intermolecular recognition site; other site 522373014222 dimerization interface [polypeptide binding]; other site 522373014223 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.7e-36 522373014224 glutathione synthetase; Provisional; Region: PRK05246 522373014225 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 522373014226 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 522373014227 HMMPfam hit to PF02951, Prokaryotic glutathione synthetase, N-termi, score 3.1e-38 522373014228 HMMPfam hit to PF08443, RimK-like ATP-grasp domain, score 5.4e-05 522373014229 HMMPfam hit to PF02955, Prokaryotic glutathione synthetase, ATP-gra, score 4.4e-121 522373014230 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 522373014231 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373014232 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 1.2e-06 522373014233 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 522373014234 Glycoprotease family; Region: Peptidase_M22; pfam00814 522373014235 HMMPfam hit to PF00814, Glycoprotease family, score 4.1e-48 522373014236 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 522373014237 DEAD/DEAH box helicase; Region: DEAD; pfam00270 522373014238 ATP binding site [chemical binding]; other site 522373014239 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 522373014240 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 522373014241 Transglycosylase; Region: Transgly; pfam00912 522373014242 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 522373014243 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.2e-07 522373014244 HMMPfam hit to PF00912, Transglycosylase, score 6.5e-72 522373014245 1 probable transmembrane helix predicted for Smlt3681 by TMHMM2.0 at aa 30-52 522373014246 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 522373014247 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 522373014248 Probable Catalytic site; other site 522373014249 HMMPfam hit to PF00535, Glycosyl transferase family, score 3.3e-21 522373014250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373014251 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 522373014252 NAD(P) binding site [chemical binding]; other site 522373014253 active site 522373014254 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 1.9e-06 522373014255 HMMPfam hit to PF07993, Male sterility protein, score 0.0023 522373014256 1 probable transmembrane helix predicted for Smlt3684 by TMHMM2.0 at aa 37-55 522373014257 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 522373014258 HD domain; Region: HD_4; pfam13328 522373014259 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 522373014260 synthetase active site [active] 522373014261 NTP binding site [chemical binding]; other site 522373014262 metal binding site [ion binding]; metal-binding site 522373014263 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 522373014264 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 522373014265 HMMPfam hit to PF01842, ACT domain, score 0.012 522373014266 HMMPfam hit to PF02824, TGS domain, score 6.6e-23 522373014267 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 1.8e-49 522373014268 DEAD-like helicases superfamily; Region: DEXDc; smart00487 522373014269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373014270 ATP binding site [chemical binding]; other site 522373014271 putative Mg++ binding site [ion binding]; other site 522373014272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373014273 nucleotide binding region [chemical binding]; other site 522373014274 ATP-binding site [chemical binding]; other site 522373014275 Helicase associated domain (HA2); Region: HA2; pfam04408 522373014276 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 522373014277 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 522373014278 HMMPfam hit to PF07717, Domain of unknown function (DUF1605), score 4.2e-18 522373014279 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 4.8e-24 522373014280 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.7e-13 522373014281 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 522373014282 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 522373014283 dimerization interface [polypeptide binding]; other site 522373014284 DPS ferroxidase diiron center [ion binding]; other site 522373014285 ion pore; other site 522373014286 HMMPfam hit to PF00210, Ferritin-like domain, score 9.9e-28 522373014287 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 522373014288 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373014289 ATP binding site [chemical binding]; other site 522373014290 putative Mg++ binding site [ion binding]; other site 522373014291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373014292 nucleotide binding region [chemical binding]; other site 522373014293 ATP-binding site [chemical binding]; other site 522373014294 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 522373014295 HRDC domain; Region: HRDC; pfam00570 522373014296 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 8.2e-29 522373014297 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.6e-26 522373014298 HMMPfam hit to PF00570, HRDC domain, score 1.3e-20 522373014299 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 522373014300 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 522373014301 Multicopper oxidase; Region: Cu-oxidase; pfam00394 522373014302 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 522373014303 HMMPfam hit to PF07732, Multicopper oxidase, score 6.4e-58 522373014304 HMMPfam hit to PF00394, Multicopper oxidase, score 1.7e-32 522373014305 HMMPfam hit to PF07731, Multicopper oxidase, score 6.2e-38 522373014306 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 522373014307 HMMPfam hit to PF05275, Copper resistance protein B precursor (CopB), score 1.7e-139 522373014308 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 522373014309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373014310 Coenzyme A binding pocket [chemical binding]; other site 522373014311 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.5e-10 522373014312 8 probable transmembrane helices predicted for Smlt3694 by TMHMM2.0 at aa 61-83, 93-115, 128-150, 165-187, 194-216, 220-239, 246-265 and 280-297 522373014313 HMMPfam hit to PF02517, CAAX amino terminal protease family, score 0.01 522373014314 Response regulator receiver domain; Region: Response_reg; pfam00072 522373014315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373014316 active site 522373014317 phosphorylation site [posttranslational modification] 522373014318 intermolecular recognition site; other site 522373014319 dimerization interface [polypeptide binding]; other site 522373014320 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.4e-17 522373014321 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 522373014322 HMMPfam hit to PF00756, Putative esterase, score 1.4e-06 522373014323 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 522373014324 HMMPfam hit to PF00756, Putative esterase, score 5.6e-08 522373014325 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 522373014326 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 522373014327 Ligand Binding Site [chemical binding]; other site 522373014328 HMMPfam hit to PF06508, ExsB, score 4e-106 522373014329 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 522373014330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373014331 FeS/SAM binding site; other site 522373014332 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.8e-10 522373014333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 522373014334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373014335 binding surface 522373014336 TPR motif; other site 522373014337 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.5e-05 522373014338 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 522373014339 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 522373014340 ligand binding site [chemical binding]; other site 522373014341 HMMPfam hit to PF00691, OmpA family, score 8.2e-30 522373014342 translocation protein TolB; Provisional; Region: tolB; PRK04922 522373014343 TolB amino-terminal domain; Region: TolB_N; pfam04052 522373014344 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 522373014345 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 522373014346 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 522373014347 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 4.5e-08 522373014348 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 2e-06 522373014349 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 1.8e-05 522373014350 HMMPfam hit to PF04052, TolB amino-terminal domain, score 2.6e-37 522373014351 TolA protein; Region: tolA_full; TIGR02794 522373014352 TonB C terminal; Region: TonB_2; pfam13103 522373014353 HMMPfam hit to PF06519, TolA protein, score 6.2e-06 522373014354 1 probable transmembrane helix predicted for Smlt3705 by TMHMM2.0 at aa 15-37 522373014355 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 522373014356 TolR protein; Region: tolR; TIGR02801 522373014357 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 9.3e-16 522373014358 1 probable transmembrane helix predicted for Smlt3706 by TMHMM2.0 at aa 20-42 522373014359 TolQ protein; Region: tolQ; TIGR02796 522373014360 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 5.6e-44 522373014361 3 probable transmembrane helices predicted for Smlt3707 by TMHMM2.0 at aa 47-69, 162-184 and 204-226 522373014362 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 522373014363 active site 522373014364 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.7e-09 522373014365 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 522373014366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373014367 Walker A motif; other site 522373014368 ATP binding site [chemical binding]; other site 522373014369 Walker B motif; other site 522373014370 arginine finger; other site 522373014371 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 522373014372 HMMPfam hit to PF05491, Holliday junction DNA helicase ruvB C-termin, score 1.4e-52 522373014373 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.3e-31 522373014374 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 5.5e-05 522373014375 HMMPfam hit to PF05496, Holliday junction DNA helicase ruvB N-termin, score 3.8e-27 522373014376 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 522373014377 potassium uptake protein; Region: kup; TIGR00794 522373014378 HMMPfam hit to PF02705, K+ potassium transporter score 9.4e-188 522373014379 12 probable transmembrane helices predicted for Smlt3710 by TMHMM2.0 at aa 21-43, 63-85, 114-136, 151-173, 185-207, 227-249, 262-284, 299-321, 350-372, 382-404, 411-430 and 435-452 522373014380 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 522373014381 RuvA N terminal domain; Region: RuvA_N; pfam01330 522373014382 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 522373014383 HMMPfam hit to PF07499, RuvA, C-terminal domain, score 1e-12 522373014384 HMMPfam hit to PF01330, RuvA N terminal domain, score 6.6e-09 522373014385 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 522373014386 active site 522373014387 putative DNA-binding cleft [nucleotide binding]; other site 522373014388 dimer interface [polypeptide binding]; other site 522373014389 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease Ruv, score 1e-65 522373014390 hypothetical protein; Validated; Region: PRK00110 522373014391 HMMPfam hit to PF01709, Domain of unknown function DUF28, score 1.2e-137 522373014392 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 522373014393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373014394 Coenzyme A binding pocket [chemical binding]; other site 522373014395 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.8e-17 522373014396 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 522373014397 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 522373014398 dimer interface [polypeptide binding]; other site 522373014399 anticodon binding site; other site 522373014400 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 522373014401 homodimer interface [polypeptide binding]; other site 522373014402 motif 1; other site 522373014403 active site 522373014404 motif 2; other site 522373014405 GAD domain; Region: GAD; pfam02938 522373014406 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 522373014407 motif 3; other site 522373014408 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 2.9e-217 522373014409 HMMPfam hit to PF02938, GAD domain, score 1e-34 522373014410 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 0.009 522373014411 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 2.2e-20 522373014412 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 522373014413 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 522373014414 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 522373014415 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 2.4e-12 522373014416 12 probable transmembrane helices predicted for Smlt3721 by TMHMM2.0 at aa 5-22, 26-43, 50-69, 79-101, 106-128, 141-163, 176-198, 213-235, 256-273, 283-305, 318-340 and 345-367 522373014417 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 522373014418 HMMPfam hit to PF00144, Beta-lactamase, score 5.5e-35 522373014419 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 522373014420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373014421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373014422 dimerization interface [polypeptide binding]; other site 522373014423 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.7e-19 522373014424 HMMPfam hit to PF03466, LysR substrate binding domain, score 5e-42 522373014425 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 522373014426 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 522373014427 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 522373014428 ABC transporter; Region: ABC_tran_2; pfam12848 522373014429 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 522373014430 HMMPfam hit to PF00005, ABC transporter score 6.4e-38 522373014431 HMMPfam hit to PF00005, ABC transporter score 4.5e-50 522373014432 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373014433 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373014434 N-terminal plug; other site 522373014435 ligand-binding site [chemical binding]; other site 522373014436 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 9e-21 522373014437 HMMPfam hit to PF00593, TonB dependent receptor, score 4.6e-31 522373014438 putative cation:proton antiport protein; Provisional; Region: PRK10669 522373014439 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 522373014440 TrkA-N domain; Region: TrkA_N; pfam02254 522373014441 12 probable transmembrane helices predicted for Smlt3726 by TMHMM2.0 at aa 27-46, 53-72, 76-98, 105-127, 131-153, 173-195, 215-237, 250-284, 304-323, 330-348, 363-385 and 392-411 522373014442 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 7.7e-85 522373014443 HMMPfam hit to PF02254, TrkA-N domain, score 1.7e-27 522373014444 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 522373014445 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 522373014446 homodimer interface [polypeptide binding]; other site 522373014447 substrate-cofactor binding pocket; other site 522373014448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373014449 catalytic residue [active] 522373014450 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 5.7e-214 522373014451 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 0.00015 522373014452 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.0014 522373014453 sensor protein RstB; Provisional; Region: PRK10604 522373014454 HAMP domain; Region: HAMP; pfam00672 522373014455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373014456 dimer interface [polypeptide binding]; other site 522373014457 phosphorylation site [posttranslational modification] 522373014458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373014459 ATP binding site [chemical binding]; other site 522373014460 Mg2+ binding site [ion binding]; other site 522373014461 G-X-G motif; other site 522373014462 2 probable transmembrane helices predicted for Smlt3730 by TMHMM2.0 at aa 19-41 and 150-172 522373014463 HMMPfam hit to PF00672, HAMP domain, score 1.7e-06 522373014464 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.3e-10 522373014465 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.6e-35 522373014466 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 522373014467 HMMPfam hit to PF06629, MltA-interacting protein MipA, score 1.1e-30 522373014468 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 522373014469 Clp amino terminal domain; Region: Clp_N; pfam02861 522373014470 Clp amino terminal domain; Region: Clp_N; pfam02861 522373014471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373014472 Walker A motif; other site 522373014473 ATP binding site [chemical binding]; other site 522373014474 Walker B motif; other site 522373014475 arginine finger; other site 522373014476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373014477 Walker A motif; other site 522373014478 ATP binding site [chemical binding]; other site 522373014479 Walker B motif; other site 522373014480 arginine finger; other site 522373014481 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 522373014482 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.8e-06 522373014483 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 3e-111 522373014484 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 3.3e-12 522373014485 HMMPfam hit to PF02861, Clp amino terminal domain, score 3.2e-12 522373014486 HMMPfam hit to PF02861, Clp amino terminal domain, score 2.8e-14 522373014487 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 522373014488 1 probable transmembrane helix predicted for Smlt3733 by TMHMM2.0 at aa 44-63 522373014489 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 522373014490 glutathione s-transferase; Provisional; Region: PTZ00057 522373014491 GSH binding site (G-site) [chemical binding]; other site 522373014492 C-terminal domain interface [polypeptide binding]; other site 522373014493 dimer interface [polypeptide binding]; other site 522373014494 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 522373014495 N-terminal domain interface [polypeptide binding]; other site 522373014496 dimer interface [polypeptide binding]; other site 522373014497 substrate binding pocket (H-site) [chemical binding]; other site 522373014498 14 probable transmembrane helices predicted for Smlt3735 by TMHMM2.0 at aa 21-43, 49-71, 90-112, 125-147, 154-176, 180-199, 211-233, 260-282, 298-320, 335-357, 390-412, 432-454, 466-483 and 498-520 522373014499 HMMPfam hit to PF00916, Sulfate transporter family, score 0.003 522373014500 pyruvate dehydrogenase; Provisional; Region: PRK09124 522373014501 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 522373014502 PYR/PP interface [polypeptide binding]; other site 522373014503 dimer interface [polypeptide binding]; other site 522373014504 tetramer interface [polypeptide binding]; other site 522373014505 TPP binding site [chemical binding]; other site 522373014506 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 522373014507 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 522373014508 TPP-binding site [chemical binding]; other site 522373014509 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 2.2e-51 522373014510 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 7.4e-25 522373014511 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 8.9e-40 522373014512 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 522373014513 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373014514 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373014515 N-terminal plug; other site 522373014516 ligand-binding site [chemical binding]; other site 522373014517 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.5e-20 522373014518 HMMPfam hit to PF00593, TonB dependent receptor, score 1.3e-26 522373014519 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 522373014520 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 522373014521 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 0.0018 522373014522 HMMPfam hit to PF02358, Trehalose-phosphatase, score 5.5e-38 522373014523 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 522373014524 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 522373014525 HMMPfam hit to PF00723, Glycosyl hydrolases family, score 1.2e-55 522373014526 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 522373014527 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 522373014528 active site 522373014529 homotetramer interface [polypeptide binding]; other site 522373014530 HMMPfam hit to PF00982, Glycosyltransferase family, score 1.1e-162 522373014531 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 522373014532 HMMPfam hit to PF04134, Protein of unknown function, DUF393, score 5.5e-50 522373014533 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 522373014534 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 522373014535 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 522373014536 HMMPfam hit to PF02578, Uncharacterised ACR, YfiH family COG1496, score 1.2e-52 522373014537 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 522373014538 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 522373014539 RNA binding surface [nucleotide binding]; other site 522373014540 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 522373014541 active site 522373014542 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.3e-67 522373014543 HMMPfam hit to PF01479, S4 domain, score 1.8e-07 522373014544 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 522373014545 Secretory lipase; Region: LIP; pfam03583 522373014546 HMMPfam hit to PF03583, Secretory lipase, score 6.1e-06 522373014547 NAD synthetase; Provisional; Region: PRK13981 522373014548 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 522373014549 multimer interface [polypeptide binding]; other site 522373014550 active site 522373014551 catalytic triad [active] 522373014552 protein interface 1 [polypeptide binding]; other site 522373014553 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 522373014554 homodimer interface [polypeptide binding]; other site 522373014555 NAD binding pocket [chemical binding]; other site 522373014556 ATP binding pocket [chemical binding]; other site 522373014557 Mg binding site [ion binding]; other site 522373014558 active-site loop [active] 522373014559 HMMPfam hit to PF02540, NAD synthase, score 2.5e-93 522373014560 HMMPfam hit to PF06508, ExsB, score 0.00044 522373014561 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 1.6e-17 522373014562 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 522373014563 CoA binding domain; Region: CoA_binding; smart00881 522373014564 CoA-ligase; Region: Ligase_CoA; pfam00549 522373014565 HMMPfam hit to PF00549, CoA-ligase, score 2.5e-60 522373014566 HMMPfam hit to PF02629, CoA binding domain, score 9.4e-49 522373014567 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 522373014568 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 522373014569 CoA-ligase; Region: Ligase_CoA; pfam00549 522373014570 HMMPfam hit to PF00549, CoA-ligase, score 1.4e-79 522373014571 HMMPfam hit to PF08442, ATP-grasp domain, score 1.4e-56 522373014572 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 522373014573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373014574 dimer interface [polypeptide binding]; other site 522373014575 phosphorylation site [posttranslational modification] 522373014576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373014577 ATP binding site [chemical binding]; other site 522373014578 Mg2+ binding site [ion binding]; other site 522373014579 G-X-G motif; other site 522373014580 5 probable transmembrane helices predicted for Smlt3754 by TMHMM2.0 at aa 110-132, 147-164, 171-193, 203-225 and 246-268 522373014581 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.9e-17 522373014582 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.9e-30 522373014583 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 522373014584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373014585 active site 522373014586 phosphorylation site [posttranslational modification] 522373014587 intermolecular recognition site; other site 522373014588 dimerization interface [polypeptide binding]; other site 522373014589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373014590 Walker A motif; other site 522373014591 ATP binding site [chemical binding]; other site 522373014592 Walker B motif; other site 522373014593 arginine finger; other site 522373014594 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 522373014595 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-42 522373014596 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.8e-133 522373014597 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 1.5e-15 522373014598 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 522373014599 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 522373014600 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 522373014601 Walker A motif; other site 522373014602 ATP binding site [chemical binding]; other site 522373014603 Walker B motif; other site 522373014604 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 1e-141 522373014605 HMMPfam hit to PF05157, GSPII_E N-terminal domain, score 1.8e-32 522373014606 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 522373014607 Pilin (bacterial filament); Region: Pilin; pfam00114 522373014608 HMMPfam hit to PF00114, Pilin (bacterial filament), score 0.0002 522373014609 1 probable transmembrane helix predicted for Smlt3757 by TMHMM2.0 at aa 31-53 522373014610 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 5.9e-07 522373014611 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 522373014612 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 522373014613 Pilin (bacterial filament); Region: Pilin; pfam00114 522373014614 HMMPfam hit to PF00114, Pilin (bacterial filament), score 0.0022 522373014615 1 probable transmembrane helix predicted for Smlt3758 by TMHMM2.0 at aa 10-32 522373014616 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 1.2e-09 522373014617 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 522373014618 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 522373014619 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 522373014620 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 2.4e-20 522373014621 4 probable transmembrane helices predicted for Smlt3759 by TMHMM2.0 at aa 231-253, 281-303, 343-365 and 437-459 522373014622 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 5.5e-18 522373014623 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 522373014624 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 522373014625 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 522373014626 6 probable transmembrane helices predicted for Smlt3760 by TMHMM2.0 at aa 27-49, 141-163, 173-191, 198-215, 243-265 and 272-294 522373014627 HMMPfam hit to PF06750, Bacterial Peptidase A24 N-terminal doma, score 1.7e-49 522373014628 HMMPfam hit to PF01478, Type IV leader peptidase family, score 4.7e-22 522373014629 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 522373014630 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 522373014631 CoA-binding site [chemical binding]; other site 522373014632 ATP-binding [chemical binding]; other site 522373014633 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 3.2e-76 522373014634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373014635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 522373014636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373014637 dimer interface [polypeptide binding]; other site 522373014638 phosphorylation site [posttranslational modification] 522373014639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373014640 ATP binding site [chemical binding]; other site 522373014641 Mg2+ binding site [ion binding]; other site 522373014642 G-X-G motif; other site 522373014643 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.7e-25 522373014644 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 7.9e-20 522373014645 HMMPfam hit to PF00672, HAMP domain, score 5.4e-11 522373014646 2 probable transmembrane helices predicted for Smlt3765 by TMHMM2.0 at aa 34-56 and 168-187 522373014647 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373014648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373014649 active site 522373014650 phosphorylation site [posttranslational modification] 522373014651 intermolecular recognition site; other site 522373014652 dimerization interface [polypeptide binding]; other site 522373014653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373014654 DNA binding site [nucleotide binding] 522373014655 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 4.9e-19 522373014656 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.4e-35 522373014657 1 probable transmembrane helix predicted for Smlt3768 by TMHMM2.0 at aa 5-24 522373014658 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 522373014659 ATP-grasp domain; Region: ATP-grasp_4; cl17255 522373014660 HMMPfam hit to PF08443, RimK-like ATP-grasp domain, score 5.6e-67 522373014661 HMMPfam hit to PF02655, ATP-grasp domain, score 0.00048 522373014662 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 522373014663 active site 522373014664 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.2e-06 522373014665 1 probable transmembrane helix predicted for Smlt3771 by TMHMM2.0 at aa 123-145 522373014666 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 522373014667 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 522373014668 active site 522373014669 catalytic triad [active] 522373014670 oxyanion hole [active] 522373014671 Autotransporter beta-domain; Region: Autotransporter; cl17461 522373014672 HMMPfam hit to PF03797, Autotransporter beta-domain, score 8.5e-28 522373014673 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 1.2e-09 522373014674 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 522373014675 thiS-thiF/thiG interaction site; other site 522373014676 HMMPfam hit to PF02597, ThiS family, score 1.3e-20 522373014677 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 522373014678 ThiS interaction site; other site 522373014679 putative active site [active] 522373014680 tetramer interface [polypeptide binding]; other site 522373014681 HMMPfam hit to PF05690, Thiazole biosynthesis protein ThiG, score 2.5e-181 522373014682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373014683 S-adenosylmethionine binding site [chemical binding]; other site 522373014684 HMMPfam hit to PF02390, Putative methyltransferase, score 3.1e-62 522373014685 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 522373014686 transmembrane helices; other site 522373014687 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 522373014688 TrkA-C domain; Region: TrkA_C; pfam02080 522373014689 TrkA-C domain; Region: TrkA_C; pfam02080 522373014690 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 522373014691 11 probable transmembrane helices predicted for Smlt3777 by TMHMM2.0 at aa 5-27, 34-50, 54-76, 143-165, 185-207, 425-442, 446-463, 476-498, 513-535, 542-564 and 592-614 522373014692 HMMPfam hit to PF03600, Citrate transporter score 5.6e-07 522373014693 HMMPfam hit to PF02080, TrkA-C domain, score 2.1e-11 522373014694 HMMPfam hit to PF02080, TrkA-C domain, score 1.3e-07 522373014695 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 522373014696 iron-sulfur cluster [ion binding]; other site 522373014697 [2Fe-2S] cluster binding site [ion binding]; other site 522373014698 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain, score 3.4e-16 522373014699 1 probable transmembrane helix predicted for Smlt3780 by TMHMM2.0 at aa 53-75 522373014700 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 522373014701 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 522373014702 HMMPfam hit to PF01557, Fumarylacetoacetate (FAA) hydrolase fam, score 2.2e-48 522373014703 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 522373014704 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 522373014705 HMMPfam hit to PF01741, Large-conductance mechanosensitive channel,, score 1.2e-66 522373014706 2 probable transmembrane helices predicted for Smlt3782 by TMHMM2.0 at aa 20-42 and 78-100 522373014707 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 522373014708 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 522373014709 PA/protease or protease-like domain interface [polypeptide binding]; other site 522373014710 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 522373014711 Peptidase family M28; Region: Peptidase_M28; pfam04389 522373014712 metal binding site [ion binding]; metal-binding site 522373014713 1 probable transmembrane helix predicted for Smlt3783 by TMHMM2.0 at aa 5-27 522373014714 HMMPfam hit to PF04389, Peptidase family M28, score 1.1e-16 522373014715 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 0.0077 522373014716 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 522373014717 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 522373014718 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 522373014719 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 2.1e-42 522373014720 HMMPfam hit to PF08032, RNA 2'-O ribose methyltransferase subs, score 4.8e-13 522373014721 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 522373014722 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 522373014723 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 2.6e-175 522373014724 10 probable transmembrane helices predicted for Smlt3785 by TMHMM2.0 at aa 37-59, 105-127, 172-194, 224-246, 253-275, 285-307, 345-367, 406-428, 448-470 and 475-497 522373014725 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 522373014726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 522373014727 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.2e-08 522373014728 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 522373014729 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373014730 12 probable transmembrane helices predicted for Smlt3787 by TMHMM2.0 at aa 12-34, 334-356, 358-380, 384-406, 431-453, 463-481, 528-545, 851-873, 880-902, 912-934, 954-976 and 986-1008 522373014731 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373014732 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373014733 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00048 522373014734 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 522373014735 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373014736 N-terminal plug; other site 522373014737 ligand-binding site [chemical binding]; other site 522373014738 HMMPfam hit to PF00593, TonB dependent receptor, score 9.6e-30 522373014739 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.9e-18 522373014740 1 probable transmembrane helix predicted for Smlt3789 by TMHMM2.0 at aa 7-29 522373014741 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680 522373014742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373014743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373014744 dimerization interface [polypeptide binding]; other site 522373014745 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.2e-43 522373014746 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.3e-15 522373014747 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 522373014748 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 522373014749 dimer interface [polypeptide binding]; other site 522373014750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373014751 catalytic residue [active] 522373014752 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 5.8e-107 522373014753 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 522373014754 putative ADP-ribose binding site [chemical binding]; other site 522373014755 putative active site [active] 522373014756 HMMPfam hit to PF01661, Appr-1-p processing enzyme family, score 5.6e-63 522373014757 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 522373014758 active site 522373014759 intersubunit interface [polypeptide binding]; other site 522373014760 catalytic residue [active] 522373014761 HMMPfam hit to PF00274, Fructose-bisphosphate aldolase class-I, score 6.9e-177 522373014762 pyruvate kinase; Provisional; Region: PRK05826 522373014763 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 522373014764 domain interfaces; other site 522373014765 active site 522373014766 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 2.5e-19 522373014767 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 6.3e-151 522373014768 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 522373014769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373014770 motif II; other site 522373014771 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.4e-29 522373014772 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 522373014773 Phosphoglycerate kinase; Region: PGK; pfam00162 522373014774 substrate binding site [chemical binding]; other site 522373014775 hinge regions; other site 522373014776 ADP binding site [chemical binding]; other site 522373014777 catalytic site [active] 522373014778 HMMPfam hit to PF00162, Phosphoglycerate kinase, score 1.2e-155 522373014779 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 522373014780 1 probable transmembrane helix predicted for Smlt3802 by TMHMM2.0 at aa 450-472 522373014781 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 522373014782 25 probable transmembrane helices predicted for Smlt3803 by TMHMM2.0 at aa 4-26, 137-154, 164-186, 193-215, 220-242, 249-267, 272-291, 296-318, 328-345, 358-375, 379-401, 414-436, 485-507, 516-533, 548-562, 569-588, 598-620, 633-652, 656-678, 698-717, 732-749, 756-778, 798-817, 824-843 and 848-870 522373014783 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 522373014784 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 522373014785 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 522373014786 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 2.9e-102 522373014787 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 8.8e-98 522373014788 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 522373014789 HMMPfam hit to PF03922, OmpW family, score 5.5e-52 522373014790 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 522373014791 active site 522373014792 Zn binding site [ion binding]; other site 522373014793 HMMPfam hit to PF02265, S1/P1 Nuclease, score 1.5e-31 522373014794 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 522373014795 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.1e-24 522373014796 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 522373014797 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 522373014798 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373014799 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 2.6e-07 522373014800 4 probable transmembrane helices predicted for Smlt3809 by TMHMM2.0 at aa 10-29, 42-64, 84-106 and 267-289 522373014801 HMMPfam hit to PF05569, BlaR1 peptidase M56, score 1.3e-31 522373014802 Penicillinase repressor; Region: Pencillinase_R; pfam03965 522373014803 HMMPfam hit to PF03965, Penicillinase repressor, score 3e-39 522373014804 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 522373014805 HMMPfam hit to PF01613, Flavin reductase like domain, score 1e-06 522373014806 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 522373014807 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 522373014808 transketolase; Reviewed; Region: PRK12753 522373014809 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 522373014810 TPP-binding site [chemical binding]; other site 522373014811 dimer interface [polypeptide binding]; other site 522373014812 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 522373014813 PYR/PP interface [polypeptide binding]; other site 522373014814 dimer interface [polypeptide binding]; other site 522373014815 TPP binding site [chemical binding]; other site 522373014816 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 522373014817 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 1.6e-15 522373014818 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 2.1e-59 522373014819 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 6.6e-216 522373014820 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 522373014821 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 522373014822 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 2.1e-72 522373014823 8 probable transmembrane helices predicted for Smlt3814 by TMHMM2.0 at aa 13-35, 58-80, 93-115, 173-192, 221-243, 248-270, 350-372 and 377-399 522373014824 Oxygen tolerance; Region: BatD; pfam13584 522373014825 Oxygen tolerance; Region: BatD; pfam13584 522373014826 1 probable transmembrane helix predicted for Smlt3815 by TMHMM2.0 at aa 426-448 522373014827 von Willebrand factor type A domain; Region: VWA_2; pfam13519 522373014828 metal ion-dependent adhesion site (MIDAS); other site 522373014829 Tetratricopeptide repeat; Region: TPR_16; pfam13432 522373014830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373014831 TPR motif; other site 522373014832 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 1.6e-08 522373014833 HMMPfam hit to PF00092, von Willebrand factor type A domain, score 0.00086 522373014834 2 probable transmembrane helices predicted for Smlt3816 by TMHMM2.0 at aa 28-45 and 74-96 522373014835 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 522373014836 metal ion-dependent adhesion site (MIDAS); other site 522373014837 1 probable transmembrane helix predicted for Smlt3817 by TMHMM2.0 at aa 312-329 522373014838 HMMPfam hit to PF00092, von Willebrand factor type A domain, score 1.5e-23 522373014839 1 probable transmembrane helix predicted for Smlt3818 by TMHMM2.0 at aa 4-18 522373014840 Protein of unknown function DUF58; Region: DUF58; pfam01882 522373014841 HMMPfam hit to PF01882, Protein of unknown function DUF58, score 9.9e-05 522373014842 MoxR-like ATPases [General function prediction only]; Region: COG0714 522373014843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373014844 Walker A motif; other site 522373014845 ATP binding site [chemical binding]; other site 522373014846 Walker B motif; other site 522373014847 arginine finger; other site 522373014848 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1e-12 522373014849 HMMPfam hit to PF07726, ATPase family associated with various cellul, score 6.6e-82 522373014850 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 522373014851 Secretin and TonB N terminus short domain; Region: STN; smart00965 522373014852 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 522373014853 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 522373014854 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 9.5e-76 522373014855 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 1.9e-10 522373014856 HMMPfam hit to PF07660, Secretin and TonB N terminus short domain, score 3.9e-11 522373014857 1 probable transmembrane helix predicted for Smlt3821 by TMHMM2.0 at aa 20-37 522373014858 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 522373014859 Pilus assembly protein, PilP; Region: PilP; pfam04351 522373014860 HMMPfam hit to PF04351, Pilus assembly protein, PilP, score 6.5e-75 522373014861 Pilus assembly protein, PilO; Region: PilO; cl01234 522373014862 HMMPfam hit to PF04350, Pilus assembly protein, PilO, score 1.8e-77 522373014863 1 probable transmembrane helix predicted for Smlt3823 by TMHMM2.0 at aa 24-43 522373014864 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 522373014865 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 522373014866 HMMPfam hit to PF05137, Fimbrial assembly protein (PilN), score 2.1e-72 522373014867 1 probable transmembrane helix predicted for Smlt3824 by TMHMM2.0 at aa 21-43 522373014868 Competence protein A; Region: Competence_A; pfam11104 522373014869 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 522373014870 Transglycosylase; Region: Transgly; pfam00912 522373014871 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 522373014872 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 522373014873 1 probable transmembrane helix predicted for Smlt3826 by TMHMM2.0 at aa 12-34 522373014874 HMMPfam hit to PF00912, Transglycosylase, score 1.2e-77 522373014875 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 2.1e-31 522373014876 1 probable transmembrane helix predicted for Smlt3828 by TMHMM2.0 at aa 50-72 522373014877 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 522373014878 trimer interface [polypeptide binding]; other site 522373014879 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 522373014880 trimer interface [polypeptide binding]; other site 522373014881 YadA-like C-terminal region; Region: YadA; pfam03895 522373014882 HMMPfam hit to PF03895, YadA-like C-terminal region, score 1.7e-06 522373014883 HMMPfam hit to PF05658, Hep_Hag, score 0.91 522373014884 HMMPfam hit to PF05658, Hep_Hag, score 0.62 522373014885 HMMPfam hit to PF05658, Hep_Hag, score 0.00069 522373014886 HMMPfam hit to PF05658, Hep_Hag, score 0.35 522373014887 HMMPfam hit to PF05658, Hep_Hag, score 0.87 522373014888 HMMPfam hit to PF05658, Hep_Hag, score 0.003 522373014889 HMMPfam hit to PF05662, Haemagglutinin, score 6.3e-05 522373014890 HMMPfam hit to PF05662, Haemagglutinin, score 3.4e-07 522373014891 HMMPfam hit to PF05658, Hep_Hag, score 0.00052 522373014892 HMMPfam hit to PF05658, Hep_Hag, score 0.68 522373014893 HMMPfam hit to PF05658, Hep_Hag, score 1.7e-05 522373014894 HMMPfam hit to PF05658, Hep_Hag, score 0.053 522373014895 HMMPfam hit to PF05658, Hep_Hag, score 0.011 522373014896 putative fimbrial protein TcfA; Provisional; Region: PRK15308 522373014897 CblD like pilus biogenesis initiator; Region: CblD; cl06460 522373014898 HMMPfam hit to PF07434, CblD like pilus biogenesis initiator, score 3.4e-26 522373014899 1 probable transmembrane helix predicted for Smlt3831 by TMHMM2.0 at aa 5-24 522373014900 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 522373014901 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 522373014902 HMMPfam hit to PF04449, CS1 type fimbrial major subunit, score 5e-18 522373014903 5 probable transmembrane helices predicted for Smlt3834 by TMHMM2.0 at aa 40-62, 82-104, 125-147, 157-179 and 333-355 522373014904 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 522373014905 dimer interface [polypeptide binding]; other site 522373014906 Citrate synthase; Region: Citrate_synt; pfam00285 522373014907 active site 522373014908 citrylCoA binding site [chemical binding]; other site 522373014909 NADH binding [chemical binding]; other site 522373014910 cationic pore residues; other site 522373014911 oxalacetate/citrate binding site [chemical binding]; other site 522373014912 coenzyme A binding site [chemical binding]; other site 522373014913 catalytic triad [active] 522373014914 HMMPfam hit to PF00285, Citrate synthase, score 5.3e-185 522373014915 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 522373014916 HMMPfam hit to PF01197, Ribosomal protein L31, score 2.2e-15 522373014917 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 522373014918 active site 522373014919 HMMPfam hit to PF01156, Inosine-uridine preferring nucleoside hy, score 1.6e-75 522373014920 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 522373014921 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 522373014922 generic binding surface II; other site 522373014923 ssDNA binding site; other site 522373014924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373014925 ATP binding site [chemical binding]; other site 522373014926 putative Mg++ binding site [ion binding]; other site 522373014927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373014928 nucleotide binding region [chemical binding]; other site 522373014929 ATP-binding site [chemical binding]; other site 522373014930 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.9e-20 522373014931 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.6e-27 522373014932 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.8e-06 522373014933 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 522373014934 homotrimer interaction site [polypeptide binding]; other site 522373014935 putative active site [active] 522373014936 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 1.3e-58 522373014937 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 522373014938 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 522373014939 Zn2+ binding site [ion binding]; other site 522373014940 Mg2+ binding site [ion binding]; other site 522373014941 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 522373014942 synthetase active site [active] 522373014943 NTP binding site [chemical binding]; other site 522373014944 metal binding site [ion binding]; metal-binding site 522373014945 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 522373014946 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 522373014947 HMMPfam hit to PF01842, ACT domain, score 0.0015 522373014948 HMMPfam hit to PF02824, TGS domain, score 2.8e-19 522373014949 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 4.9e-45 522373014950 HMMPfam hit to PF01966, HD domain, score 1.4e-15 522373014951 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 522373014952 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 3.7e-18 522373014953 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 522373014954 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 522373014955 catalytic site [active] 522373014956 G-X2-G-X-G-K; other site 522373014957 HMMPfam hit to PF00625, Guanylate kinase, score 5.8e-40 522373014958 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 522373014959 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 522373014960 [4Fe-4S] binding site [ion binding]; other site 522373014961 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 522373014962 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 522373014963 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 522373014964 molybdopterin cofactor binding site; other site 522373014965 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 7.8e-22 522373014966 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 7.3e-10 522373014967 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 2.1e-10 522373014968 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 522373014969 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 522373014970 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.1e-05 522373014971 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 522373014972 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 522373014973 HMMPfam hit to PF01292, Cytochrome b561 family, score 0.0021 522373014974 4 probable transmembrane helices predicted for Smlt3846 by TMHMM2.0 at aa 21-43, 58-76, 119-141 and 156-178 522373014975 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 522373014976 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 522373014977 HMMPfam hit to PF04216, Protein involved in formate dehydrogenase fo, score 2e-52 522373014978 selenocysteine synthase; Provisional; Region: PRK04311 522373014979 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 522373014980 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373014981 catalytic residue [active] 522373014982 HMMPfam hit to PF03841, L-seryl-tRNA selenium transferase, score 1.9e-207 522373014983 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 0.00011 522373014984 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.00029 522373014985 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 522373014986 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 522373014987 G1 box; other site 522373014988 putative GEF interaction site [polypeptide binding]; other site 522373014989 GTP/Mg2+ binding site [chemical binding]; other site 522373014990 Switch I region; other site 522373014991 G2 box; other site 522373014992 G3 box; other site 522373014993 Switch II region; other site 522373014994 G4 box; other site 522373014995 G5 box; other site 522373014996 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 522373014997 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 522373014998 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 522373014999 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 522373015000 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2.7e-32 522373015001 HMMPfam hit to PF03144, Elongation factor Tu domain, score 7.8e-12 522373015002 selenophosphate synthetase; Provisional; Region: PRK00943 522373015003 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 522373015004 dimerization interface [polypeptide binding]; other site 522373015005 putative ATP binding site [chemical binding]; other site 522373015006 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 2.4e-07 522373015007 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 4.3e-22 522373015008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373015009 non-specific DNA binding site [nucleotide binding]; other site 522373015010 salt bridge; other site 522373015011 sequence-specific DNA binding site [nucleotide binding]; other site 522373015012 HMMPfam hit to PF01381, Helix-turn-helix, score 1e-06 522373015013 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 522373015014 hypothetical protein; Provisional; Region: PRK11820 522373015015 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 522373015016 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 522373015017 HMMPfam hit to PF08340, Domain of unknown function (DUF1732), score 7.2e-55 522373015018 HMMPfam hit to PF03755, YicC-like family, N-terminal region, score 8.7e-53 522373015019 ribonuclease PH; Reviewed; Region: rph; PRK00173 522373015020 Ribonuclease PH; Region: RNase_PH_bact; cd11362 522373015021 hexamer interface [polypeptide binding]; other site 522373015022 active site 522373015023 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 9.7e-51 522373015024 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 7.5e-19 522373015025 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373015026 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 522373015027 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 7.9e-20 522373015028 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 522373015029 active site 522373015030 dimerization interface [polypeptide binding]; other site 522373015031 HMMPfam hit to PF01725, Ham1 family, score 1.5e-85 522373015032 HemN family oxidoreductase; Provisional; Region: PRK05660 522373015033 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373015034 FeS/SAM binding site; other site 522373015035 HemN C-terminal domain; Region: HemN_C; pfam06969 522373015036 HMMPfam hit to PF04055, Radical SAM superfamily, score 3.5e-29 522373015037 HMMPfam hit to PF06969, HemN C-terminal region, score 7.7e-28 522373015038 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 522373015039 HMMPfam hit to PF07793, Protein of unknown function (DUF1631), score 4.6e-198 522373015040 PilZ domain; Region: PilZ; pfam07238 522373015041 HMMPfam hit to PF07238, PilZ domain, score 1.1e-10 522373015042 proline dipeptidase; Provisional; Region: PRK13607 522373015043 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 522373015044 active site 522373015045 HMMPfam hit to PF00557, metallopeptidase family M24, score 6.2e-45 522373015046 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 522373015047 proline aminopeptidase P II; Provisional; Region: PRK10879 522373015048 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 522373015049 active site 522373015050 HMMPfam hit to PF00557, metallopeptidase family M24, score 4.4e-78 522373015051 HMMPfam hit to PF05195, Aminopeptidase P, N-terminal domain, score 4.4e-66 522373015052 hypothetical protein; Validated; Region: PRK04758 522373015053 HMMPfam hit to PF03695, Uncharacterised protein family (UPF0149), score 1.7e-47 522373015054 Cell division protein ZapA; Region: ZapA; cl01146 522373015055 HMMPfam hit to PF05164, Cell division protein ZapA, score 6.9e-27 522373015056 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 522373015057 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 1.2e-35 522373015058 Uncharacterized conserved protein [Function unknown]; Region: COG2947 522373015059 HMMPfam hit to PF04543, Family of unknown function (DUF589), score 8.7e-91 522373015060 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 522373015061 tetramer (dimer of dimers) interface [polypeptide binding]; other site 522373015062 active site 522373015063 dimer interface [polypeptide binding]; other site 522373015064 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase A (phosph, score 5.2e-99 522373015065 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 522373015066 HMMPfam hit to PF02643, Uncharacterized ACR, COG1430, score 3.9e-57 522373015067 Uncharacterized conserved protein [Function unknown]; Region: COG2912 522373015068 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 522373015069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373015070 binding surface 522373015071 TPR motif; other site 522373015072 Rubredoxin [Energy production and conversion]; Region: COG1773 522373015073 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 522373015074 iron binding site [ion binding]; other site 522373015075 HMMPfam hit to PF00301, Rubredoxin, score 6e-22 522373015076 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 522373015077 thiamine phosphate binding site [chemical binding]; other site 522373015078 active site 522373015079 pyrophosphate binding site [ion binding]; other site 522373015080 HMMPfam hit to PF02581, Thiamine monophosphate synthase/TENI, score 2.6e-69 522373015081 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 522373015082 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 522373015083 inhibitor-cofactor binding pocket; inhibition site 522373015084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373015085 catalytic residue [active] 522373015086 HMMPfam hit to PF00202, Aminotransferase class-III, score 9.6e-92 522373015087 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 522373015088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373015089 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 522373015090 motif II; other site 522373015091 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 7.2e-14 522373015092 acetylornithine transaminase protein; Provisional; Region: argD; PRK04612 522373015093 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 522373015094 inhibitor-cofactor binding pocket; inhibition site 522373015095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373015096 catalytic residue [active] 522373015097 HMMPfam hit to PF00202, Aminotransferase class-III, score 1.1e-143 522373015098 Ion transport protein; Region: Ion_trans; pfam00520 522373015099 Ion channel; Region: Ion_trans_2; pfam07885 522373015100 6 probable transmembrane helices predicted for Smlt3877 by TMHMM2.0 at aa 69-91, 101-123, 130-152, 195-216, 228-250 and 254-276 522373015101 HMMPfam hit to PF00520, Ion transport protein, score 6.3e-29 522373015102 HMMPfam hit to PF07885, Ion channel, score 1.7e-16 522373015103 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 522373015104 short chain dehydrogenase; Provisional; Region: PRK08278 522373015105 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 522373015106 NAD(P) binding site [chemical binding]; other site 522373015107 homodimer interface [polypeptide binding]; other site 522373015108 active site 522373015109 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.4e-07 522373015110 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 522373015111 serine/threonine protein kinase; Provisional; Region: PRK12274 522373015112 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 522373015113 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 522373015114 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 522373015115 active site 522373015116 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 522373015117 LssY C-terminus; Region: LssY_C; pfam14067 522373015118 12 probable transmembrane helices predicted for Smlt3883 by TMHMM2.0 at aa 28-50, 57-79, 83-105, 166-188, 203-225, 267-289, 319-341, 348-370, 380-402, 414-433, 437-459 and 466-488 522373015119 HMMPfam hit to PF01569, PAP2 superfamily, score 7.5e-12 522373015120 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 522373015121 HMMPfam hit to PF02190, ATP-dependent protease La (LON) domain, score 2.1e-06 522373015122 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 522373015123 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 522373015124 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 522373015125 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 522373015126 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 2.6e-09 522373015127 HMMPfam hit to PF08245, Mur ligase middle domain, score 8.2e-24 522373015128 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 5e-19 522373015129 adenylate kinase; Reviewed; Region: adk; PRK00279 522373015130 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 522373015131 AMP-binding site [chemical binding]; other site 522373015132 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 522373015133 HMMPfam hit to PF00406, Adenylate kinase, score 7.6e-89 522373015134 6-phosphofructokinase; Provisional; Region: PRK14072 522373015135 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 522373015136 active site 522373015137 ADP/pyrophosphate binding site [chemical binding]; other site 522373015138 dimerization interface [polypeptide binding]; other site 522373015139 allosteric effector site; other site 522373015140 fructose-1,6-bisphosphate binding site; other site 522373015141 HMMPfam hit to PF00365, Phosphofructokinase, score 2.1e-10 522373015142 Protein of unknown function, DUF488; Region: DUF488; cl01246 522373015143 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 522373015144 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 522373015145 HMMPfam hit to PF03030, Inorganic H+ pyrophosphatase, score 0 522373015146 14 probable transmembrane helices predicted for Smlt3891 by TMHMM2.0 at aa 20-39, 43-65, 85-107, 122-144, 194-216, 220-242, 255-277, 282-304, 334-356, 360-382, 426-448, 463-480, 531-553 and 557-579 522373015147 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 522373015148 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373015149 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 1.3e-05 522373015150 1 probable transmembrane helix predicted for Smlt3892 by TMHMM2.0 at aa 7-29 522373015151 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 522373015152 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 522373015153 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 6.2e-15 522373015154 1 probable transmembrane helix predicted for Smlt3893 by TMHMM2.0 at aa 21-43 522373015155 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 522373015156 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 9.2e-40 522373015157 3 probable transmembrane helices predicted for Smlt3894 by TMHMM2.0 at aa 30-52, 138-160 and 180-202 522373015158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 522373015159 HMMPfam hit to PF04304, Protein of unknown function (DUF454), score 4.2e-08 522373015160 3 probable transmembrane helices predicted for Smlt3895 by TMHMM2.0 at aa 15-37, 74-93 and 97-114 522373015161 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 522373015162 heme binding pocket [chemical binding]; other site 522373015163 heme ligand [chemical binding]; other site 522373015164 HMMPfam hit to PF01126, Heme oxygenase, score 5.3e-20 522373015165 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 522373015166 Secretin and TonB N terminus short domain; Region: STN; smart00965 522373015167 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373015168 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373015169 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373015170 HMMPfam hit to PF00593, TonB dependent receptor, score 9.2e-26 522373015171 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 9.6e-12 522373015172 HMMPfam hit to PF07660, Secretin and TonB N terminus short domai, score 0.00023 522373015173 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 522373015174 FecR protein; Region: FecR; pfam04773 522373015175 HMMPfam hit to PF04773, FecR protein, score 9.7e-31 522373015176 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 522373015177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373015178 DNA binding residues [nucleotide binding] 522373015179 HMMPfam hit to PF04545, Sigma-70, region, score 4.6e-10 522373015180 HMMPfam hit to PF08281, Sigma-70, region, score 9.3e-17 522373015181 HMMPfam hit to PF04542, Sigma-70 region, score 2.1e-07 522373015182 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 522373015183 substrate binding site [chemical binding]; other site 522373015184 metal binding sites [ion binding]; metal-binding site 522373015185 dimer interface [polypeptide binding]; other site 522373015186 HMMPfam hit to PF00719, Inorganic pyrophosphatase, score 5e-59 522373015187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 522373015188 active site 522373015189 phosphorylation site [posttranslational modification] 522373015190 intermolecular recognition site; other site 522373015191 HDOD domain; Region: HDOD; pfam08668 522373015192 HMMPfam hit to PF00072, Response regulator receiver domain, score 0.00017 522373015193 1 probable transmembrane helix predicted for Smlt3904 by TMHMM2.0 at aa 30-52 522373015194 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 522373015195 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373015196 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373015197 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373015198 HMMPfam hit to PF00593, TonB dependent receptor, score 3.2e-21 522373015199 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.1e-14 522373015200 Helix-turn-helix domain; Region: HTH_18; pfam12833 522373015201 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 6.5e-05 522373015202 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.00012 522373015203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373015204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373015205 DNA binding site [nucleotide binding] 522373015206 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 522373015207 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 522373015208 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 1.2e-05 522373015209 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.0012 522373015210 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.22 522373015211 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.0021 522373015212 1 probable transmembrane helix predicted for Smlt3907 by TMHMM2.0 at aa 166-185 522373015213 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 6.7e-17 522373015214 HMMPfam hit to PF07885, Ion channel, score 9.8e-08 522373015215 6 probable transmembrane helices predicted for Smlt3908 by TMHMM2.0 at aa 59-76, 80-102, 107-129, 134-156, 168-190 and 237-259 522373015216 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 522373015217 ThiC-associated domain; Region: ThiC-associated; pfam13667 522373015218 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 522373015219 HMMPfam hit to PF01964, ThiC family, score 0 522373015220 BCCT family transporter; Region: BCCT; pfam02028 522373015221 HMMPfam hit to PF02028, BCCT family transporter score 8.5e-194 522373015222 12 probable transmembrane helices predicted for Smlt3910 by TMHMM2.0 at aa 49-71, 86-107, 128-147, 175-197, 226-248, 258-280, 296-318, 347-369, 382-404, 435-457, 481-503 and 507-529 522373015223 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 522373015224 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 522373015225 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 8.3e-212 522373015226 ketol-acid reductoisomerase; Provisional; Region: PRK05479 522373015227 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 522373015228 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 522373015229 HMMPfam hit to PF07991, Acetohydroxy acid isomeroreductase, catalyti, score 1.2e-97 522373015230 HMMPfam hit to PF01450, Acetohydroxy acid isomeroreductase, catalyti, score 8e-81 522373015231 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 522373015232 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 522373015233 PYR/PP interface [polypeptide binding]; other site 522373015234 dimer interface [polypeptide binding]; other site 522373015235 TPP binding site [chemical binding]; other site 522373015236 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 522373015237 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 522373015238 TPP-binding site [chemical binding]; other site 522373015239 dimer interface [polypeptide binding]; other site 522373015240 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 3.6e-92 522373015241 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 6.7e-53 522373015242 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 3.9e-71 522373015243 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 522373015244 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 522373015245 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 522373015246 tetramer interface [polypeptide binding]; other site 522373015247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373015248 catalytic residue [active] 522373015249 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 5.2e-54 522373015250 2-isopropylmalate synthase; Validated; Region: PRK00915 522373015251 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 522373015252 active site 522373015253 catalytic residues [active] 522373015254 metal binding site [ion binding]; metal-binding site 522373015255 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 522373015256 HMMPfam hit to PF00682, HMGL-like, score 8e-112 522373015257 HMMPfam hit to PF08502, LeuA allosteric (dimerisation) domain, score 1.4e-40 522373015258 Methyltransferase domain; Region: Methyltransf_31; pfam13847 522373015259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373015260 S-adenosylmethionine binding site [chemical binding]; other site 522373015261 HMMPfam hit to PF05175, Methyltransferase small domain, score 0.00013 522373015262 HMMPfam hit to PF07021, Methionine biosynthesis protein MetW, score 0.00055 522373015263 HMMPfam hit to PF08241, Methyltransferase domain, score 1.1e-27 522373015264 HMMPfam hit to PF08242, Methyltransferase domain, score 1.7e-20 522373015265 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 522373015266 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 522373015267 substrate binding site [chemical binding]; other site 522373015268 ligand binding site [chemical binding]; other site 522373015269 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 2.5e-202 522373015270 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 522373015271 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 522373015272 substrate binding site [chemical binding]; other site 522373015273 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 4.9e-35 522373015274 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 522373015275 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 6.6e-201 522373015276 short chain dehydrogenase; Provisional; Region: PRK12744 522373015277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373015278 NAD(P) binding site [chemical binding]; other site 522373015279 active site 522373015280 HMMPfam hit to PF00106, short chain dehydrogenase, score 7e-13 522373015281 transcriptional regulator; Provisional; Region: PRK10632 522373015282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373015283 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 522373015284 putative effector binding pocket; other site 522373015285 putative dimerization interface [polypeptide binding]; other site 522373015286 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.2e-18 522373015287 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.4e-38 522373015288 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 522373015289 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 1.2e-80 522373015290 11 probable transmembrane helices predicted for Smlt3924 by TMHMM2.0 at aa 13-32, 356-378, 391-413, 433-452, 465-487, 558-580, 895-912, 917-939, 944-966, 992-1014 and 1021-1043 522373015291 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373015292 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373015293 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373015294 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00023 522373015295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373015296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373015297 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 522373015298 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 522373015299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373015300 S-adenosylmethionine binding site [chemical binding]; other site 522373015301 HMMPfam hit to PF01135, Protein-L-isoaspartate(D-aspartate) O, score 1.3e-11 522373015302 HMMPfam hit to PF08241, Methyltransferase domain, score 1.5e-07 522373015303 HMMPfam hit to PF08242, Methyltransferase domain, score 5.2e-07 522373015304 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 522373015305 HMMPfam hit to PF02321, Outer membrane efflux protein, score 9.6e-28 522373015306 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.9e-39 522373015307 11 probable transmembrane helices predicted for Smlt3929 by TMHMM2.0 at aa 19-41, 46-68, 89-111, 131-150, 157-179, 203-225, 238-260, 287-309, 330-347, 351-373 and 380-397 522373015308 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 522373015309 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 522373015310 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 522373015311 HMMPfam hit to PF04413, 3-Deoxy-D-manno-octulosonic-acid tran, score 6.6e-102 522373015312 1 probable transmembrane helix predicted for Smlt3930 by TMHMM2.0 at aa 12-31 522373015313 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 522373015314 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 522373015315 putative acyl-acceptor binding pocket; other site 522373015316 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 7.7e-71 522373015317 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 522373015318 O-Antigen ligase; Region: Wzy_C; pfam04932 522373015319 8 probable transmembrane helices predicted for Smlt3932 by TMHMM2.0 at aa 58-80, 93-112, 132-149, 156-178, 251-273, 286-308, 382-404 and 424-446 522373015320 HMMPfam hit to PF04932, O-Antigen Polymerase, score 1.1e-16 522373015321 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 522373015322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 522373015323 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.8e-10 522373015324 Zinc-finger domain; Region: zf-CHCC; cl01821 522373015325 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 522373015326 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 522373015327 HMMPfam hit to PF07971, Glycosyl hydrolase family, score 2.2e-174 522373015328 Peptidase of plants and bacteria; Region: BSP; pfam04450 522373015329 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 522373015330 Winged helix-turn helix; Region: HTH_29; pfam13551 522373015331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 522373015332 Integrase core domain; Region: rve; pfam00665 522373015333 Integrase core domain; Region: rve_3; pfam13683 522373015334 HMMPfam hit to PF00665, Integrase core domain, score 4.9e-39 522373015335 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 522373015336 Malic enzyme, N-terminal domain; Region: malic; pfam00390 522373015337 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 522373015338 putative NAD(P) binding site [chemical binding]; other site 522373015339 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 522373015340 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 1.9e-100 522373015341 HMMPfam hit to PF03949, Malic enzyme, NAD binding domain, score 2.5e-124 522373015342 HMMPfam hit to PF00390, Malic enzyme, N-terminal domain, score 7.2e-77 522373015343 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 522373015344 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 522373015345 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 1.4e-180 522373015346 9 probable transmembrane helices predicted for Smlt3942 by TMHMM2.0 at aa 20-42, 51-73, 88-110, 152-174, 184-203, 210-232, 236-258, 325-347 and 362-384 522373015347 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 522373015348 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 522373015349 HMMPfam hit to PF07396, Phosphate-selective porin O and P, score 3.7e-140 522373015350 PAS domain; Region: PAS; smart00091 522373015351 PAS fold; Region: PAS_7; pfam12860 522373015352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373015353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373015354 dimer interface [polypeptide binding]; other site 522373015355 phosphorylation site [posttranslational modification] 522373015356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373015357 ATP binding site [chemical binding]; other site 522373015358 Mg2+ binding site [ion binding]; other site 522373015359 G-X-G motif; other site 522373015360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373015361 Response regulator receiver domain; Region: Response_reg; pfam00072 522373015362 active site 522373015363 phosphorylation site [posttranslational modification] 522373015364 intermolecular recognition site; other site 522373015365 dimerization interface [polypeptide binding]; other site 522373015366 1 probable transmembrane helix predicted for Smlt3944 by TMHMM2.0 at aa 9-31 522373015367 HMMPfam hit to PF08448, PAS fold, score 9e-05 522373015368 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 5.3e-13 522373015369 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.2e-28 522373015370 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.8e-15 522373015371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373015372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373015373 active site 522373015374 phosphorylation site [posttranslational modification] 522373015375 intermolecular recognition site; other site 522373015376 dimerization interface [polypeptide binding]; other site 522373015377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373015378 DNA binding residues [nucleotide binding] 522373015379 dimerization interface [polypeptide binding]; other site 522373015380 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 2.9e-22 522373015381 HMMPfam hit to PF08281, Sigma-70, region, score 1.2e-05 522373015382 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.4e-23 522373015383 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 522373015384 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 522373015385 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 2e-07 522373015386 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 522373015387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373015388 dimer interface [polypeptide binding]; other site 522373015389 phosphorylation site [posttranslational modification] 522373015390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373015391 ATP binding site [chemical binding]; other site 522373015392 Mg2+ binding site [ion binding]; other site 522373015393 G-X-G motif; other site 522373015394 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.1e-36 522373015395 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 8.3e-14 522373015396 HMMPfam hit to PF00672, HAMP domain, score 1.3e-07 522373015397 2 probable transmembrane helices predicted for Smlt3948 by TMHMM2.0 at aa 25-47 and 176-198 522373015398 HMMPfam hit to PF08521, Two-component sensor kinase N-terminal, score 1.6e-61 522373015399 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 522373015400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373015401 active site 522373015402 phosphorylation site [posttranslational modification] 522373015403 intermolecular recognition site; other site 522373015404 dimerization interface [polypeptide binding]; other site 522373015405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373015406 DNA binding site [nucleotide binding] 522373015407 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 6.1e-20 522373015408 HMMPfam hit to PF00072, Response regulator receiver domain, score 7.5e-33 522373015409 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 522373015410 HMMPfam hit to PF07396, Phosphate-selective porin O and P, score 9.7e-122 522373015411 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 522373015412 Citrate transporter; Region: CitMHS; pfam03600 522373015413 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 0.0011 522373015414 11 probable transmembrane helices predicted for Smlt3951 by TMHMM2.0 at aa 2-19, 23-45, 57-79, 99-121, 133-155, 175-197, 240-259, 263-282, 295-317, 332-351 and 416-438 522373015415 HMMPfam hit to PF03600, Citrate transporter score 1.2e-175 522373015416 HMMPfam hit to PF06808, DctM-like transporters, score 0.0023 522373015417 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 522373015418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373015419 NAD(P) binding site [chemical binding]; other site 522373015420 active site 522373015421 HMMPfam hit to PF00106, short chain dehydrogenase, score 3e-32 522373015422 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.00078 522373015423 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 522373015424 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373015425 N-terminal plug; other site 522373015426 ligand-binding site [chemical binding]; other site 522373015427 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.8e-10 522373015428 HMMPfam hit to PF00593, TonB dependent receptor, score 1.1e-25 522373015429 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 522373015430 HMMPfam hit to PF08014, Domain of unknown function (DUF1704), score 9.4e-154 522373015431 GTPase RsgA; Reviewed; Region: PRK01889 522373015432 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 522373015433 GTPase/Zn-binding domain interface [polypeptide binding]; other site 522373015434 GTP/Mg2+ binding site [chemical binding]; other site 522373015435 G4 box; other site 522373015436 G5 box; other site 522373015437 G1 box; other site 522373015438 Switch I region; other site 522373015439 G2 box; other site 522373015440 G3 box; other site 522373015441 Switch II region; other site 522373015442 HMMPfam hit to PF03193, Protein of unknown function, DUF258, score 2.3e-121 522373015443 aminotransferase AlaT; Validated; Region: PRK09265 522373015444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373015445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373015446 homodimer interface [polypeptide binding]; other site 522373015447 catalytic residue [active] 522373015448 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.1e-43 522373015449 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 522373015450 active site 522373015451 catalytic triad [active] 522373015452 oxyanion hole [active] 522373015453 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 3.8e-05 522373015454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373015455 S-adenosylmethionine binding site [chemical binding]; other site 522373015456 HMMPfam hit to PF08241, Methyltransferase domain, score 6.4e-08 522373015457 HMMPfam hit to PF08242, Methyltransferase domain, score 2.9e-12 522373015458 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 522373015459 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 522373015460 NodB motif; other site 522373015461 active site 522373015462 catalytic site [active] 522373015463 metal binding site [ion binding]; metal-binding site 522373015464 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 4.9e-39 522373015465 1 probable transmembrane helix predicted for Smlt3960 by TMHMM2.0 at aa 20-42 522373015466 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 522373015467 putative GSH binding site [chemical binding]; other site 522373015468 catalytic residues [active] 522373015469 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 522373015470 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 522373015471 active site residue [active] 522373015472 HMMPfam hit to PF00462, Glutaredoxin, score 4.1e-28 522373015473 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 3.5e-06 522373015474 HMMPfam hit to PF00581, Rhodanese-like domain, score 1.4e-06 522373015475 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 522373015476 HMMPfam hit to PF06041, Bacterial protein of unknown function (DUF92, score 2.5e-99 522373015477 AMP nucleosidase; Provisional; Region: PRK07115 522373015478 HMMPfam hit to PF01048, Phosphorylase family, score 1.7e-10 522373015479 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 522373015480 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 522373015481 active site 522373015482 HMMPfam hit to PF01979, Amidohydrolase family, score 5.9e-05 522373015483 HMMPfam hit to PF07969, Amidohydrolase family, score 0.0002 522373015484 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 522373015485 active site 522373015486 HMMPfam hit to PF01979, Amidohydrolase family, score 0.0062 522373015487 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 522373015488 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 522373015489 putative catalytic residue [active] 522373015490 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 5.6e-33 522373015491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 522373015492 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 522373015493 HMMPfam hit to PF02645, Uncharacterized protein, DegV family COG1307, score 2.9e-35 522373015494 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 522373015495 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.3e-33 522373015496 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.6e-26 522373015497 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 522373015498 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373015499 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373015500 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.4e-28 522373015501 1 probable transmembrane helix predicted for Smlt3970 by TMHMM2.0 at aa 7-26 522373015502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373015503 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 522373015504 putative substrate translocation pore; other site 522373015505 14 probable transmembrane helices predicted for Smlt3971 by TMHMM2.0 at aa 25-47, 67-89, 96-118, 123-145, 152-174, 184-203, 216-238, 248-265, 286-308, 323-345, 352-374, 389-408, 415-437 and 480-497 522373015506 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.6e-24 522373015507 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 522373015508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373015509 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 522373015510 putative substrate binding pocket [chemical binding]; other site 522373015511 putative dimerization interface [polypeptide binding]; other site 522373015512 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.6e-11 522373015513 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.5e-17 522373015514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 522373015515 Ligand Binding Site [chemical binding]; other site 522373015516 HMMPfam hit to PF00582, Universal stress protein family, score 5.4e-15 522373015517 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373015518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373015519 metal binding site [ion binding]; metal-binding site 522373015520 active site 522373015521 I-site; other site 522373015522 HMMPfam hit to PF00990, GGDEF domain, score 4.7e-65 522373015523 9 probable transmembrane helices predicted for Smlt3975 by TMHMM2.0 at aa 43-65, 69-91, 98-120, 130-151, 158-180, 200-217, 226-248, 288-310 and 317-336 522373015524 S-formylglutathione hydrolase; Region: PLN02442 522373015525 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 522373015526 HMMPfam hit to PF00756, Putative esterase, score 6.5e-98 522373015527 tRNA pseudouridine synthase C; Region: DUF446; cl01187 522373015528 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 522373015529 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 522373015530 substrate binding site [chemical binding]; other site 522373015531 catalytic Zn binding site [ion binding]; other site 522373015532 NAD binding site [chemical binding]; other site 522373015533 structural Zn binding site [ion binding]; other site 522373015534 dimer interface [polypeptide binding]; other site 522373015535 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 2.6e-35 522373015536 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 4.5e-36 522373015537 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 522373015538 putative metal binding site [ion binding]; other site 522373015539 putative homodimer interface [polypeptide binding]; other site 522373015540 putative homotetramer interface [polypeptide binding]; other site 522373015541 putative homodimer-homodimer interface [polypeptide binding]; other site 522373015542 putative allosteric switch controlling residues; other site 522373015543 HMMPfam hit to PF02583, Uncharacterised BCR, COG1937, score 4.7e-13 522373015544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373015545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373015546 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 522373015547 putative effector binding pocket; other site 522373015548 putative dimerization interface [polypeptide binding]; other site 522373015549 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-45 522373015550 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 7.6e-20 522373015551 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 522373015552 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 522373015553 FMN binding site [chemical binding]; other site 522373015554 active site 522373015555 substrate binding site [chemical binding]; other site 522373015556 catalytic residue [active] 522373015557 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 7.6e-81 522373015558 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 522373015559 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 522373015560 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373015561 active site 522373015562 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 5.6e-09 522373015563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373015564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373015565 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2.2e-14 522373015566 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373015567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373015568 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 522373015569 putative effector binding pocket; other site 522373015570 putative dimerization interface [polypeptide binding]; other site 522373015571 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.8e-45 522373015572 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 9.4e-05 522373015573 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 522373015574 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 522373015575 putative NAD(P) binding site [chemical binding]; other site 522373015576 putative substrate binding site [chemical binding]; other site 522373015577 catalytic Zn binding site [ion binding]; other site 522373015578 structural Zn binding site [ion binding]; other site 522373015579 dimer interface [polypeptide binding]; other site 522373015580 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 3.4e-38 522373015581 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 5.1e-32 522373015582 glutamate--cysteine ligase; Region: PLN02611 522373015583 HMMPfam hit to PF04107, Glutamate-cysteine ligase family 2(GCS2), score 3.5e-124 522373015584 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 522373015585 HMMPfam hit to PF01988, Integral membrane protein DUF125, score 3.7e-87 522373015586 4 probable transmembrane helices predicted for Smlt3989 by TMHMM2.0 at aa 30-52, 150-172, 177-199 and 209-231 522373015587 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 522373015588 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.6e-17 522373015589 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 522373015590 G1 box; other site 522373015591 GTP/Mg2+ binding site [chemical binding]; other site 522373015592 Switch I region; other site 522373015593 G2 box; other site 522373015594 G3 box; other site 522373015595 Switch II region; other site 522373015596 G4 box; other site 522373015597 G5 box; other site 522373015598 HMMPfam hit to PF01926, GTPase of unknown function, score 7e-28 522373015599 Cytochrome c553 [Energy production and conversion]; Region: COG2863 522373015600 Cytochrome c; Region: Cytochrom_C; cl11414 522373015601 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 522373015602 catalytic residues [active] 522373015603 hinge region; other site 522373015604 alpha helical domain; other site 522373015605 1 probable transmembrane helix predicted for Smlt3993 by TMHMM2.0 at aa 54-76 522373015606 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 1.8e-08 522373015607 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 522373015608 catalytic residues [active] 522373015609 hinge region; other site 522373015610 alpha helical domain; other site 522373015611 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 7.8e-07 522373015612 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 522373015613 putative catalytic site [active] 522373015614 putative metal binding site [ion binding]; other site 522373015615 putative phosphate binding site [ion binding]; other site 522373015616 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 3e-17 522373015617 threonine and homoserine efflux system; Provisional; Region: PRK10532 522373015618 10 probable transmembrane helices predicted for Smlt3996 by TMHMM2.0 at aa 5-27, 37-59, 72-91, 96-115, 122-144, 149-166, 179-201, 206-224, 237-256 and 260-282 522373015619 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.3e-20 522373015620 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 0.00088 522373015621 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 522373015622 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 522373015623 putative DNA binding site [nucleotide binding]; other site 522373015624 putative Zn2+ binding site [ion binding]; other site 522373015625 AsnC family; Region: AsnC_trans_reg; pfam01037 522373015626 HMMPfam hit to PF01037, AsnC family, score 3.9e-20 522373015627 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 522373015628 Peptidase family M23; Region: Peptidase_M23; pfam01551 522373015629 1 probable transmembrane helix predicted for Smlt3998 by TMHMM2.0 at aa 13-32 522373015630 HMMPfam hit to PF01551, Peptidase family M23, score 1.1e-23 522373015631 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 522373015632 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373015633 N-terminal plug; other site 522373015634 ligand-binding site [chemical binding]; other site 522373015635 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.6e-18 522373015636 HMMPfam hit to PF00593, TonB dependent receptor, score 3.6e-26 522373015637 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 522373015638 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373015639 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373015640 HMMPfam hit to PF00593, TonB dependent receptor, score 8.1e-24 522373015641 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 7.5e-14 522373015642 lytic murein transglycosylase; Provisional; Region: PRK11619 522373015643 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 522373015644 N-acetyl-D-glucosamine binding site [chemical binding]; other site 522373015645 catalytic residue [active] 522373015646 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 8.3e-31 522373015647 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 522373015648 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 522373015649 active site 522373015650 NTP binding site [chemical binding]; other site 522373015651 metal binding triad [ion binding]; metal-binding site 522373015652 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 522373015653 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 522373015654 Zn2+ binding site [ion binding]; other site 522373015655 Mg2+ binding site [ion binding]; other site 522373015656 HMMPfam hit to PF01743, Poly A polymerase family, score 2.2e-58 522373015657 HMMPfam hit to PF01966, HD domain, score 1.5e-05 522373015658 SseB protein; Region: SseB; cl06279 522373015659 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 522373015660 active site flap/lid [active] 522373015661 nucleophilic elbow; other site 522373015662 catalytic triad [active] 522373015663 conserved hypothetical protein, pseudogene;Similar to N-terminus of Xanthomonas oryzae pv. oryzae (strain maff 311018). hypothetical protein xoo3585. UniProt:Q2NZD7 (EMBL:AP008229 (263 aa) fasta scores: E()=1.1e-05, 30.392% id in 102 aa; similarity:fasta; with=UniProt:Q2NZD7 (EMBL:AP008229;); Xanthomonas oryzae pv. oryzae (strain MAFF 311018).; Hypothetical protein XOO3585.; length=263; id 30.392%; ungapped id 30.392%; E()=1.1e-05; 102 aa overlap; query 1-102; subject 2-103 522373015664 1 probable transmembrane helix predicted for Smlt4013 by TMHMM2.0 at aa 86-105 522373015665 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 522373015666 Active site serine [active] 522373015667 HMMPfam hit to PF03572, Peptidase family S41, score 1.3e-07 522373015668 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 522373015669 Autotransporter beta-domain; Region: Autotransporter; smart00869 522373015670 HMMPfam hit to PF03797, Autotransporter beta-domain, score 6.5e-26 522373015671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 522373015672 9 probable transmembrane helices predicted for Smlt4019 by TMHMM2.0 at aa 52-71, 91-108, 113-135, 142-164, 195-217, 222-244, 254-273, 286-308 and 323-345 522373015673 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 522373015674 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 522373015675 active site 522373015676 dimer interface [polypeptide binding]; other site 522373015677 HMMPfam hit to PF01979, Amidohydrolase family, score 1.8e-16 522373015678 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 522373015679 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 522373015680 dimer interface [polypeptide binding]; other site 522373015681 active site 522373015682 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 522373015683 dimer interface [polypeptide binding]; other site 522373015684 active site 522373015685 HMMPfam hit to PF01380, SIS domain, score 5.9e-11 522373015686 HMMPfam hit to PF01380, SIS domain, score 4.4e-18 522373015687 Transcriptional regulators [Transcription]; Region: PurR; COG1609 522373015688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 522373015689 DNA binding site [nucleotide binding] 522373015690 domain linker motif; other site 522373015691 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 522373015692 putative dimerization interface [polypeptide binding]; other site 522373015693 putative ligand binding site [chemical binding]; other site 522373015694 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.1e-12 522373015695 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 2.7e-11 522373015696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373015697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373015698 putative substrate translocation pore; other site 522373015699 glucose/galactose transporter; Region: gluP; TIGR01272 522373015700 12 probable transmembrane helices predicted for Smlt4023 by TMHMM2.0 at aa 34-56, 76-98, 105-124, 128-150, 171-193, 219-241, 271-293, 308-330, 337-356, 361-383, 395-414 and 420-442 522373015701 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 8.2e-16 522373015702 glucokinase; Provisional; Region: PRK12408 522373015703 glucokinase, proteobacterial type; Region: glk; TIGR00749 522373015704 HMMPfam hit to PF02685, Glucokinase, score 1.8e-132 522373015705 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 522373015706 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373015707 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373015708 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.4e-19 522373015709 HMMPfam hit to PF00593, TonB dependent receptor, score 1.4e-25 522373015710 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 522373015711 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 522373015712 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 522373015713 active site 522373015714 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C_1; pfam13290 522373015715 1 probable transmembrane helix predicted for Smlt4027 by TMHMM2.0 at aa 13-35 522373015716 HMMPfam hit to PF02838, Glycosyl hydrolase family 20, domain, score 0.00099 522373015717 HMMPfam hit to PF00728, Glycosyl hydrolase family 20, catalyt, score 4.5e-157 522373015718 VanZ like family; Region: VanZ; cl01971 522373015719 HMMPfam hit to PF04892, VanZ like family, score 6.1e-06 522373015720 4 probable transmembrane helices predicted for Smlt4028 by TMHMM2.0 at aa 17-39, 49-66, 71-93 and 103-125 522373015721 Uncharacterized conserved protein [Function unknown]; Region: COG1565 522373015722 HMMPfam hit to PF02636, Uncharacterized ACR, COG1565, score 6.7e-76 522373015723 pteridine reductase; Provisional; Region: PRK09135 522373015724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373015725 NAD(P) binding site [chemical binding]; other site 522373015726 active site 522373015727 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.4e-12 522373015728 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.0018 522373015729 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 522373015730 catalytic center binding site [active] 522373015731 ATP binding site [chemical binding]; other site 522373015732 HMMPfam hit to PF01288, 7,8-dihydro-6-hydroxymethylpterin-pyrophosph, score 1.5e-24 522373015733 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 522373015734 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 522373015735 active site 522373015736 conserved hypothetical protein, pseudogene 522373015737 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373015738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373015739 active site 522373015740 phosphorylation site [posttranslational modification] 522373015741 intermolecular recognition site; other site 522373015742 dimerization interface [polypeptide binding]; other site 522373015743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373015744 ATP binding site [chemical binding]; other site 522373015745 Mg2+ binding site [ion binding]; other site 522373015746 G-X-G motif; other site 522373015747 cheY-homologous receiver domain; Region: REC; smart00448 522373015748 phosphorylation site [posttranslational modification] 522373015749 HMMPfam hit to PF00072, Response regulator receiver domain, score 0.0014 522373015750 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.5e-36 522373015751 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 8.3e-06 522373015752 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-18 522373015753 Response regulator receiver domain; Region: Response_reg; pfam00072 522373015754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373015755 active site 522373015756 phosphorylation site [posttranslational modification] 522373015757 intermolecular recognition site; other site 522373015758 dimerization interface [polypeptide binding]; other site 522373015759 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.3e-18 522373015760 CHASE3 domain; Region: CHASE3; pfam05227 522373015761 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 522373015762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373015763 dimer interface [polypeptide binding]; other site 522373015764 phosphorylation site [posttranslational modification] 522373015765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373015766 ATP binding site [chemical binding]; other site 522373015767 Mg2+ binding site [ion binding]; other site 522373015768 G-X-G motif; other site 522373015769 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 8e-32 522373015770 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.1e-11 522373015771 HMMPfam hit to PF08448, PAS fold, score 1.7e-07 522373015772 2 probable transmembrane helices predicted for Smlt4039 by TMHMM2.0 at aa 15-34 and 184-203 522373015773 HMMPfam hit to PF05227, CHASE3 domain, score 1.6e-08 522373015774 BON domain; Region: BON; pfam04972 522373015775 HMMPfam hit to PF04972, Putative phospholipid-binding domain, score 4.7e-14 522373015776 putative oxidoreductase; Provisional; Region: PRK11579 522373015777 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 522373015778 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 522373015779 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 2.4e-29 522373015780 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindin, score 0.0001 522373015781 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 7e-17 522373015782 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 522373015783 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 522373015784 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-ter, score 7.1e-07 522373015785 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 1.7e-53 522373015786 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 522373015787 carboxy-terminal protease; Provisional; Region: PRK11186 522373015788 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 522373015789 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 522373015790 protein binding site [polypeptide binding]; other site 522373015791 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 522373015792 Catalytic dyad [active] 522373015793 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 522373015794 HMMPfam hit to PF03572, Peptidase family S41, score 1.4e-65 522373015795 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.5e-11 522373015796 lipoyl synthase; Provisional; Region: PRK05481 522373015797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373015798 FeS/SAM binding site; other site 522373015799 HMMPfam hit to PF04055, Radical SAM superfamily, score 6.6e-25 522373015800 lipoate-protein ligase B; Provisional; Region: PRK14342 522373015801 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 1.1e-13 522373015802 hypothetical protein; Provisional; Region: PRK00907 522373015803 HMMPfam hit to PF04359, Protein of unknown function (DUF493), score 4.5e-33 522373015804 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 522373015805 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 522373015806 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 522373015807 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 522373015808 HMMPfam hit to PF07943, Penicillin-binding protein 5, C-termina, score 2.4e-32 522373015809 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 1e-95 522373015810 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 522373015811 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 522373015812 Sporulation related domain; Region: SPOR; pfam05036 522373015813 HMMPfam hit to PF05036, Sporulation related domain, score 3.1e-09 522373015814 HMMPfam hit to PF03330, Rare lipoprotein A (RlpA)-like double-psi be, score 2.6e-39 522373015815 Transglycosylase SLT domain; Region: SLT_2; pfam13406 522373015816 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 522373015817 N-acetyl-D-glucosamine binding site [chemical binding]; other site 522373015818 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 522373015819 HMMPfam hit to PF01098, Cell cycle protein, score 6.1e-104 522373015820 7 probable transmembrane helices predicted for Smlt4054 by TMHMM2.0 at aa 21-43, 68-90, 140-162, 177-199, 268-290, 305-327 and 334-356 522373015821 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 522373015822 HMMPfam hit to PF01098, Cell cycle protein, score 1.4e-107 522373015823 9 probable transmembrane helices predicted for Smlt4055 by TMHMM2.0 at aa 21-38, 48-70, 77-99, 133-155, 160-177, 181-203, 272-294, 309-331 and 338-360 522373015824 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 522373015825 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 522373015826 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 522373015827 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.9e-75 522373015828 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 1.1e-61 522373015829 1 probable transmembrane helix predicted for Smlt4056 by TMHMM2.0 at aa 21-40 522373015830 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 522373015831 HMMPfam hit to PF04093, rod shape-determining protein MreD, score 3e-37 522373015832 4 probable transmembrane helices predicted for Smlt4057 by TMHMM2.0 at aa 9-31, 51-73, 94-116 and 131-151 522373015833 rod shape-determining protein MreC; Provisional; Region: PRK13922 522373015834 rod shape-determining protein MreC; Region: MreC; pfam04085 522373015835 HMMPfam hit to PF04085, rod shape-determining protein MreC, score 7.6e-60 522373015836 rod shape-determining protein MreB; Provisional; Region: PRK13927 522373015837 MreB and similar proteins; Region: MreB_like; cd10225 522373015838 nucleotide binding site [chemical binding]; other site 522373015839 Mg binding site [ion binding]; other site 522373015840 putative protofilament interaction site [polypeptide binding]; other site 522373015841 RodZ interaction site [polypeptide binding]; other site 522373015842 HMMPfam hit to PF06723, MreB/Mbl protein, score 5.7e-230 522373015843 HMMPfam hit to PF02491, Cell division protein FtsA, score 0.00029 522373015844 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 522373015845 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 522373015846 substrate binding site [chemical binding]; other site 522373015847 ATP binding site [chemical binding]; other site 522373015848 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 3.3e-28 522373015849 putative transposase, pseudogene;Similar to N-terminus of Leifsonia xyli subsp. xyli Tnp transposase, islxx4. UniProt:Q6AEV8 (121 aa) fasta scores: E()=8.3, 40.909% id in 44 aa; similarity:fasta; with=UniProt:Q6AEV8; Leifsonia xyli subsp. xyli.; tnp; Transposase, ISlxx4.; length=121; id 40.909%; ungapped id 46.154%; E()=8.3; 44 aa overlap; query 12-50; subject 10-53 522373015850 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 522373015851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373015852 motif II; other site 522373015853 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 5.2e-19 522373015854 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 522373015855 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 522373015856 active site 522373015857 Zn binding site [ion binding]; other site 522373015858 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 522373015859 HMMPfam hit to PF01433, Peptidase family M1, score 4.7e-65 522373015860 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 522373015861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373015862 S-adenosylmethionine binding site [chemical binding]; other site 522373015863 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 3.2e-116 522373015864 HMMPfam hit to PF08241, Methyltransferase domain, score 8.2e-24 522373015865 HMMPfam hit to PF08242, Methyltransferase domain, score 5.2e-09 522373015866 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 522373015867 nucleoside/Zn binding site; other site 522373015868 dimer interface [polypeptide binding]; other site 522373015869 catalytic motif [active] 522373015870 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 1.6e-27 522373015871 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 522373015872 Low affinity iron permease; Region: Iron_permease; pfam04120 522373015873 HMMPfam hit to PF07300, Protein of unknown function (DUF1452), score 9.8e-62 522373015874 2 probable transmembrane helices predicted for Smlt4069 by TMHMM2.0 at aa 21-43 and 47-66 522373015875 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 522373015876 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.5e-53 522373015877 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.1e-36 522373015878 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 522373015879 Protein export membrane protein; Region: SecD_SecF; cl14618 522373015880 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373015881 12 probable transmembrane helices predicted for Smlt4071 by TMHMM2.0 at aa 9-28, 340-359, 366-388, 392-414, 438-460, 470-492, 542-564, 613-635, 877-894, 898-920, 976-998 and 1008-1030 522373015882 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373015883 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373015884 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373015885 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.2e-64 522373015886 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 522373015887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373015888 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 522373015889 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 3.2e-19 522373015890 HMMPfam hit to PF08361, MAATS-type transcriptional repressor, C-term, score 0.00012 522373015891 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 522373015892 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 522373015893 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 1.3e-27 522373015894 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 1.7e-08 522373015895 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 522373015896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373015897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 522373015898 Walker A motif; other site 522373015899 ATP binding site [chemical binding]; other site 522373015900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373015901 Walker B motif; other site 522373015902 arginine finger; other site 522373015903 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 522373015904 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 8.7e-49 522373015905 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 522373015906 active site 522373015907 HslU subunit interaction site [polypeptide binding]; other site 522373015908 HMMPfam hit to PF00227, Proteasome A-type and B-type, score 2.7e-35 522373015909 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 522373015910 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 522373015911 active site 522373015912 DNA binding site [nucleotide binding] 522373015913 Int/Topo IB signature motif; other site 522373015914 HMMPfam hit to PF00589, Phage integrase family, score 2e-50 522373015915 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 2e-25 522373015916 Protein of unknown function, DUF484; Region: DUF484; cl17449 522373015917 HMMPfam hit to PF04340, Protein of unknown function, DUF484, score 1.6e-81 522373015918 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 522373015919 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 522373015920 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 522373015921 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 3.3e-30 522373015922 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 2.4e-29 522373015923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 522373015924 HMMPfam hit to PF04304, Protein of unknown function (DUF454), score 5e-19 522373015925 2 probable transmembrane helices predicted for Smlt4081 by TMHMM2.0 at aa 23-45 and 94-116 522373015926 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 522373015927 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373015928 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 4.5e-103 522373015929 HMMPfam hit to PF02897, Prolyl oligopeptidase, N-terminal beta, score 9.8e-150 522373015930 hypothetical protein; Provisional; Region: PRK08960 522373015931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373015932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373015933 homodimer interface [polypeptide binding]; other site 522373015934 catalytic residue [active] 522373015935 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.3e-47 522373015936 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.0007 522373015937 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 522373015938 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373015939 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 3.2e-57 522373015940 HMMPfam hit to PF02897, Prolyl oligopeptidase, N-terminal beta, score 2.7e-36 522373015941 2 probable transmembrane helices predicted for Smlt4085 by TMHMM2.0 at aa 58-80 and 84-106 522373015942 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 522373015943 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 522373015944 HMMPfam hit to PF08212, Lipocalin-like domain, score 2e-51 522373015945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 522373015946 dimer interface [polypeptide binding]; other site 522373015947 conserved gate region; other site 522373015948 ABC-ATPase subunit interface; other site 522373015949 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.4e-16 522373015950 5 probable transmembrane helices predicted for Smlt4087 by TMHMM2.0 at aa 31-53, 66-88, 98-120, 158-180 and 200-219 522373015951 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 522373015952 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 522373015953 Walker A/P-loop; other site 522373015954 ATP binding site [chemical binding]; other site 522373015955 Q-loop/lid; other site 522373015956 ABC transporter signature motif; other site 522373015957 Walker B; other site 522373015958 D-loop; other site 522373015959 H-loop/switch region; other site 522373015960 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 522373015961 HMMPfam hit to PF00005, ABC transporter score 2.2e-72 522373015962 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 522373015963 EamA-like transporter family; Region: EamA; pfam00892 522373015964 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 7.9e-05 522373015965 8 probable transmembrane helices predicted for Smlt4089 by TMHMM2.0 at aa 7-25, 40-59, 72-91, 96-118, 127-144, 148-170, 183-205 and 264-281 522373015966 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 6.6e-15 522373015967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 522373015968 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 522373015969 HMMPfam hit to PF04461, Protein of unknown function (DUF520), score 5e-69 522373015970 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 522373015971 HMMPfam hit to PF07209, Protein of unknown function (DUF1415), score 2.4e-116 522373015972 oxidoreductase; Validated; Region: PRK05717 522373015973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373015974 NAD(P) binding site [chemical binding]; other site 522373015975 active site 522373015976 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.9e-16 522373015977 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 522373015978 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 522373015979 active site 522373015980 Zn binding site [ion binding]; other site 522373015981 HMMPfam hit to PF01432, Peptidase family M3, score 1.4e-175 522373015982 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 522373015983 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 522373015984 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373015985 catalytic residue [active] 522373015986 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.6e-47 522373015987 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 522373015988 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373015989 dimer interface [polypeptide binding]; other site 522373015990 active site 522373015991 metal binding site [ion binding]; metal-binding site 522373015992 glutathione binding site [chemical binding]; other site 522373015993 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 1.8e-38 522373015994 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 522373015995 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373015996 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 9.8e-14 522373015997 FOG: CBS domain [General function prediction only]; Region: COG0517 522373015998 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 522373015999 HMMPfam hit to PF00571, CBS domain pair, score 3.8e-24 522373016000 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 522373016001 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 522373016002 glutaminase active site [active] 522373016003 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 522373016004 dimer interface [polypeptide binding]; other site 522373016005 active site 522373016006 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 522373016007 dimer interface [polypeptide binding]; other site 522373016008 active site 522373016009 HMMPfam hit to PF01380, SIS domain, score 4.6e-31 522373016010 HMMPfam hit to PF01380, SIS domain, score 5.7e-30 522373016011 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 8.6e-37 522373016012 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373016013 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373016014 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373016015 1 probable transmembrane helix predicted for Smlt4100 by TMHMM2.0 at aa 29-48 522373016016 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.0032 522373016017 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 522373016018 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 522373016019 Walker A/P-loop; other site 522373016020 ATP binding site [chemical binding]; other site 522373016021 Q-loop/lid; other site 522373016022 ABC transporter signature motif; other site 522373016023 Walker B; other site 522373016024 D-loop; other site 522373016025 H-loop/switch region; other site 522373016026 HMMPfam hit to PF00005, ABC transporter score 1.2e-59 522373016027 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373016028 FtsX-like permease family; Region: FtsX; pfam02687 522373016029 4 probable transmembrane helices predicted for Smlt4102 by TMHMM2.0 at aa 21-43, 309-331, 358-380 and 395-417 522373016030 HMMPfam hit to PF02687, Predicted permease, score 6.7e-24 522373016031 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373016032 FtsX-like permease family; Region: FtsX; pfam02687 522373016033 4 probable transmembrane helices predicted for Smlt4103 by TMHMM2.0 at aa 16-38, 285-307, 336-358 and 368-390 522373016034 HMMPfam hit to PF02687, Predicted permease, score 2e-27 522373016035 PDZ domain; Region: PDZ_2; pfam13180 522373016036 1 probable transmembrane helix predicted for Smlt4104 by TMHMM2.0 at aa 21-43 522373016037 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 522373016038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373016039 active site 522373016040 phosphorylation site [posttranslational modification] 522373016041 intermolecular recognition site; other site 522373016042 dimerization interface [polypeptide binding]; other site 522373016043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373016044 Walker A motif; other site 522373016045 ATP binding site [chemical binding]; other site 522373016046 Walker B motif; other site 522373016047 arginine finger; other site 522373016048 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 522373016049 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.2e-23 522373016050 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.1e-124 522373016051 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 7.3e-11 522373016052 HAMP domain; Region: HAMP; pfam00672 522373016053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373016054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373016055 ATP binding site [chemical binding]; other site 522373016056 Mg2+ binding site [ion binding]; other site 522373016057 G-X-G motif; other site 522373016058 2 probable transmembrane helices predicted for Smlt4106 by TMHMM2.0 at aa 9-31 and 35-54 522373016059 HMMPfam hit to PF00672, HAMP domain, score 1.5e-05 522373016060 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.9e-31 522373016061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373016062 Coenzyme A binding pocket [chemical binding]; other site 522373016063 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 8.7e-11 522373016064 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 522373016065 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 522373016066 Substrate binding site; other site 522373016067 Mg++ binding site; other site 522373016068 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 522373016069 active site 522373016070 substrate binding site [chemical binding]; other site 522373016071 CoA binding site [chemical binding]; other site 522373016072 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.12 522373016073 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 3.2 522373016074 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 20 522373016075 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 10 522373016076 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 3.7 522373016077 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 18 522373016078 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.1e-06 522373016079 Predicted membrane protein [Function unknown]; Region: COG2246 522373016080 GtrA-like protein; Region: GtrA; pfam04138 522373016081 4 probable transmembrane helices predicted for Smlt4109 by TMHMM2.0 at aa 43-65, 69-88, 109-131 and 141-160 522373016082 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 522373016083 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 522373016084 gamma subunit interface [polypeptide binding]; other site 522373016085 epsilon subunit interface [polypeptide binding]; other site 522373016086 LBP interface [polypeptide binding]; other site 522373016087 HMMPfam hit to PF00401, ATP synthase, Delta/Epsilon chain, long, score 0.017 522373016088 HMMPfam hit to PF02823, ATP synthase, Delta/Epsilon chain, beta, score 1.8e-22 522373016089 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 522373016090 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 522373016091 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 522373016092 alpha subunit interaction interface [polypeptide binding]; other site 522373016093 Walker A motif; other site 522373016094 ATP binding site [chemical binding]; other site 522373016095 Walker B motif; other site 522373016096 inhibitor binding site; inhibition site 522373016097 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 522373016098 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 1.8e-50 522373016099 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 5.2e-92 522373016100 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 2.4e-26 522373016101 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 522373016102 core domain interface [polypeptide binding]; other site 522373016103 delta subunit interface [polypeptide binding]; other site 522373016104 epsilon subunit interface [polypeptide binding]; other site 522373016105 HMMPfam hit to PF00231, ATP synthase, score 2.9e-146 522373016106 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 522373016107 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 522373016108 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 522373016109 beta subunit interaction interface [polypeptide binding]; other site 522373016110 Walker A motif; other site 522373016111 ATP binding site [chemical binding]; other site 522373016112 Walker B motif; other site 522373016113 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 522373016114 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 1.6e-31 522373016115 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 3.2e-116 522373016116 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 1.6e-15 522373016117 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 522373016118 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 522373016119 HMMPfam hit to PF00213, ATP synthase delta (OSCP) subunit, score 2.3e-40 522373016120 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 522373016121 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 522373016122 HMMPfam hit to PF00430, ATP synthase B/B' CF(0), score 3.4e-32 522373016123 1 probable transmembrane helix predicted for Smlt4115 by TMHMM2.0 at aa 27-49 522373016124 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 522373016125 HMMPfam hit to PF00137, ATP synthase subunit C, score 2e-16 522373016126 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 522373016127 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 522373016128 HMMPfam hit to PF00119, ATP synthase A chain, score 1.9e-66 522373016129 5 probable transmembrane helices predicted for Smlt4117 by TMHMM2.0 at aa 33-55, 93-115, 135-157, 210-232 and 237-259 522373016130 4 probable transmembrane helices predicted for Smlt4118 by TMHMM2.0 at aa 5-24, 34-56, 63-85 and 89-108 522373016131 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 522373016132 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 522373016133 E3 interaction surface; other site 522373016134 lipoyl attachment site [posttranslational modification]; other site 522373016135 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 522373016136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373016137 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 522373016138 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 2.1e-49 522373016139 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 4.8e-63 522373016140 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 3.3e-30 522373016141 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 1.2e-25 522373016142 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 522373016143 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 522373016144 E3 interaction surface; other site 522373016145 lipoyl attachment site [posttranslational modification]; other site 522373016146 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 522373016147 E3 interaction surface; other site 522373016148 lipoyl attachment site [posttranslational modification]; other site 522373016149 e3 binding domain; Region: E3_binding; pfam02817 522373016150 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 522373016151 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 9e-124 522373016152 HMMPfam hit to PF02817, e3 binding domain, score 5.8e-14 522373016153 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 2.3e-23 522373016154 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 1.8e-23 522373016155 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 522373016156 putative active site [active] 522373016157 OmpW family; Region: OmpW; cl17427 522373016158 HMMPfam hit to PF03922, OmpW family, score 2e-39 522373016159 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 522373016160 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 6.6e-55 522373016161 glycerol kinase; Provisional; Region: glpK; PRK00047 522373016162 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 522373016163 N- and C-terminal domain interface [polypeptide binding]; other site 522373016164 active site 522373016165 MgATP binding site [chemical binding]; other site 522373016166 catalytic site [active] 522373016167 metal binding site [ion binding]; metal-binding site 522373016168 glycerol binding site [chemical binding]; other site 522373016169 homotetramer interface [polypeptide binding]; other site 522373016170 homodimer interface [polypeptide binding]; other site 522373016171 FBP binding site [chemical binding]; other site 522373016172 protein IIAGlc interface [polypeptide binding]; other site 522373016173 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 4.1e-120 522373016174 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 4.5e-84 522373016175 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 522373016176 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 522373016177 HMMPfam hit to PF03180, NLPA lipoprotein, score 1.4e-142 522373016178 Predicted transcriptional regulator [Transcription]; Region: COG2378 522373016179 HTH domain; Region: HTH_11; pfam08279 522373016180 WYL domain; Region: WYL; pfam13280 522373016181 HMMPfam hit to PF08279, HTH domain, score 2.6e-13 522373016182 Protein of unknown function, DUF481; Region: DUF481; pfam04338 522373016183 HMMPfam hit to PF04338, Protein of unknown function, DUF481, score 1.3e-79 522373016184 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 522373016185 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 522373016186 domain interfaces; other site 522373016187 active site 522373016188 HMMPfam hit to PF03900, Porphobilinogen deaminase, C-terminal, score 3.5e-21 522373016189 HMMPfam hit to PF01379, Porphobilinogen deaminase, dipyrometh, score 8.5e-119 522373016190 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 522373016191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373016192 active site 522373016193 phosphorylation site [posttranslational modification] 522373016194 intermolecular recognition site; other site 522373016195 dimerization interface [polypeptide binding]; other site 522373016196 LytTr DNA-binding domain; Region: LytTR; pfam04397 522373016197 HMMPfam hit to PF04397, LytTr DNA-binding domain, score 4.5e-27 522373016198 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.8e-36 522373016199 Histidine kinase; Region: His_kinase; pfam06580 522373016200 HMMPfam hit to PF06580, Histidine kinase, score 9.3e-32 522373016201 4 probable transmembrane helices predicted for Smlt4131 by TMHMM2.0 at aa 20-37, 47-69, 82-104 and 119-141 522373016202 putative hydrolase; Provisional; Region: PRK11460 522373016203 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 522373016204 HMMPfam hit to PF02230, Phospholipase/Carboxylesterase, score 4.1e-59 522373016205 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 522373016206 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 522373016207 Ligand binding site; other site 522373016208 DXD motif; other site 522373016209 7 probable transmembrane helices predicted for Smlt4133 by TMHMM2.0 at aa 53-75, 90-112, 413-435, 462-484, 497-519, 546-568 and 575-597 522373016210 HMMPfam hit to PF00535, Glycosyl transferase family, score 0.00026 522373016211 putative glucosyltransferase, pseudogene;Similar to codons 210 to 270 of Sorghum bicolor (sorghum) (sorghum vulgare). 131l1.9b UniProt:Q5NKS3 (EMBL:AF488412 (292 aa) fasta scores: E()=0.46, 38.462% id in 65 aa; similarity:fasta; with=UniProt:Q5NKS3 (EMBL:AF488412;); Sorghum bicolor (Sorghum) (Sorghum vulgare).; 131L1.9b; Putative flavonol glucosyltransferase.; length=292; id 38.462%; ungapped id 40.323%; E()=0.46; 65 aa overlap; query 26-90; subject 210-271 522373016212 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 522373016213 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373016214 N-terminal plug; other site 522373016215 ligand-binding site [chemical binding]; other site 522373016216 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.8e-30 522373016217 HMMPfam hit to PF00593, TonB dependent receptor, score 9.4e-36 522373016218 conserved hypothetical protein, pseudogene;Similar to C-terminus of hypothetical protein. UniProt:Q7WX46 (EMBL:AY305378 (227 aa) fasta scores: E()=2.4, 36.486% id in 74 aa; similarity:fasta; with=UniProt:Q7WX46 (EMBL:AY305378;); 337)).; Hypothetical protein.; length=227; id 36.486%; ungapped id 40.909%; E()=2.4; 74 aa overlap; query 3-69; subject 146-218 522373016219 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 522373016220 2 probable transmembrane helices predicted for Smlt4137 by TMHMM2.0 at aa 50-68 and 73-95 522373016221 Cache domain; Region: Cache_1; pfam02743 522373016222 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 522373016223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 522373016224 dimerization interface [polypeptide binding]; other site 522373016225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373016226 dimer interface [polypeptide binding]; other site 522373016227 putative CheW interface [polypeptide binding]; other site 522373016228 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.2e-95 522373016229 HMMPfam hit to PF00672, HAMP domain, score 2.8e-12 522373016230 2 probable transmembrane helices predicted for Smlt4138 by TMHMM2.0 at aa 99-118 and 403-425 522373016231 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 522373016232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373016233 NAD(P) binding site [chemical binding]; other site 522373016234 active site 522373016235 HMMPfam hit to PF04321, RmlD substrate binding domain, score 0.00011 522373016236 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 3e-07 522373016237 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 3.1e-06 522373016238 HMMPfam hit to PF07993, Male sterility protein, score 0.0024 522373016239 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 0.0031 522373016240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373016241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 522373016242 putative substrate translocation pore; other site 522373016243 12 probable transmembrane helices predicted for Smlt4141 by TMHMM2.0 at aa 7-29, 44-66, 134-156, 166-185, 198-217, 222-244, 265-287, 302-321, 328-347, 357-379, 400-419 and 461-483 522373016244 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-59 522373016245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373016246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373016247 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 5.2e-13 522373016248 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 522373016249 dimer interface [polypeptide binding]; other site 522373016250 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373016251 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 1.3e-13 522373016252 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 522373016253 catalytic triad [active] 522373016254 putative active site [active] 522373016255 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 522373016256 Autotransporter beta-domain; Region: Autotransporter; pfam03797 522373016257 HMMPfam hit to PF00082, Subtilase family, score 2.9e-28 522373016258 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.4e-33 522373016259 1 probable transmembrane helix predicted for Smlt4147 by TMHMM2.0 at aa 21-43 522373016260 RHS Repeat; Region: RHS_repeat; pfam05593 522373016261 HMMPfam hit to PF05593, RHS Repeat, score 0.039 522373016262 HMMPfam hit to PF05593, RHS Repeat, score 6 522373016263 HMMPfam hit to PF05593, RHS Repeat, score 0.098 522373016264 HMMPfam hit to PF05593, RHS Repeat, score 1.3e-05 522373016265 HMMPfam hit to PF05593, RHS Repeat, score 6.4 522373016266 HMMPfam hit to PF05593, RHS Repeat, score 3.9 522373016267 HMMPfam hit to PF05593, RHS Repeat, score 0.039 522373016268 HMMPfam hit to PF05593, RHS Repeat, score 0.00098 522373016269 HMMPfam hit to PF05593, RHS Repeat, score 6.8 522373016270 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 522373016271 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 522373016272 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373016273 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373016274 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373016275 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.8e-20 522373016276 HMMPfam hit to PF00593, TonB dependent receptor, score 6.7e-21 522373016277 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 522373016278 EamA-like transporter family; Region: EamA; cl17759 522373016279 EamA-like transporter family; Region: EamA; pfam00892 522373016280 10 probable transmembrane helices predicted for Smlt4153 by TMHMM2.0 at aa 20-42, 52-69, 82-104, 114-131, 138-160, 170-187, 200-222, 226-248, 261-278 and 282-304 522373016281 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2.4e-12 522373016282 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.4e-22 522373016283 Cupin domain; Region: Cupin_2; pfam07883 522373016284 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 522373016285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373016286 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 0.00095 522373016287 HMMPfam hit to PF07883, Cupin domain, score 0.00053 522373016288 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 2.4e-05 522373016289 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 3.1e-05 522373016290 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 522373016291 putative C-terminal domain interface [polypeptide binding]; other site 522373016292 putative GSH binding site (G-site) [chemical binding]; other site 522373016293 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 522373016294 putative dimer interface [polypeptide binding]; other site 522373016295 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 522373016296 dimer interface [polypeptide binding]; other site 522373016297 N-terminal domain interface [polypeptide binding]; other site 522373016298 putative substrate binding pocket (H-site) [chemical binding]; other site 522373016299 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 8.6e-10 522373016300 3 probable transmembrane helices predicted for Smlt4156 by TMHMM2.0 at aa 13-35, 48-70 and 104-126 522373016301 H-NS histone family; Region: Histone_HNS; pfam00816 522373016302 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 522373016303 HMMPfam hit to PF00816, H-NS histone family, score 4.9e-19 522373016304 Predicted membrane protein [Function unknown]; Region: COG2259 522373016305 4 probable transmembrane helices predicted for Smlt4158 by TMHMM2.0 at aa 7-29, 44-66, 71-89 and 104-123 522373016306 HMMPfam hit to PF07681, DoxX, score 5.3e-37 522373016307 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373016308 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373016309 HMMPfam hit to PF00144, Beta-lactamase, score 8e-55 522373016310 1 probable transmembrane helix predicted for Smlt4159 by TMHMM2.0 at aa 28-50 522373016311 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 522373016312 active site 522373016313 catalytic residues [active] 522373016314 Family description; Region: VCBS; pfam13517 522373016315 Family description; Region: VCBS; pfam13517 522373016316 FG-GAP repeat; Region: FG-GAP; pfam01839 522373016317 Family description; Region: VCBS; pfam13517 522373016318 HMMPfam hit to PF00722, Glycosyl hydrolases family, score 8.9e-11 522373016319 HMMPfam hit to PF01839, FG-GAP repeat, score 2.8e-05 522373016320 HMMPfam hit to PF01839, FG-GAP repeat, score 8.8e-05 522373016321 HMMPfam hit to PF01839, FG-GAP repeat, score 2.4e-05 522373016322 HMMPfam hit to PF01839, FG-GAP repeat, score 2.7e-05 522373016323 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 522373016324 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 522373016325 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 522373016326 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 522373016327 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 522373016328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373016329 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 522373016330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373016331 DNA binding residues [nucleotide binding] 522373016332 HMMPfam hit to PF04545, Sigma-70, region, score 2e-23 522373016333 HMMPfam hit to PF04539, Sigma-70 region, score 8.1e-44 522373016334 HMMPfam hit to PF04542, Sigma-70 region, score 2e-28 522373016335 HMMPfam hit to PF04546, Sigma-70, non-essential region, score 2.2e-67 522373016336 HMMPfam hit to PF00140, Sigma-70 factor, region, score 5.1e-16 522373016337 HMMPfam hit to PF03979, Sigma-70 factor, region, score 2.9e-38 522373016338 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 522373016339 putative active site [active] 522373016340 dimerization interface [polypeptide binding]; other site 522373016341 putative tRNAtyr binding site [nucleotide binding]; other site 522373016342 HMMPfam hit to PF02580, D-Tyr-tRNA(Tyr) deacylase, score 3.5e-73 522373016343 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 1.3e-15 522373016344 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 522373016345 putative acyl-acceptor binding pocket; other site 522373016346 GTP cyclohydrolase; Provisional; Region: PRK08815 522373016347 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 522373016348 dimerization interface [polypeptide binding]; other site 522373016349 active site 522373016350 HMMPfam hit to PF00925, GTP cyclohydrolase II, score 1.1e-48 522373016351 Bacterial PH domain; Region: DUF304; pfam03703 522373016352 2 probable transmembrane helices predicted for Smlt4169 by TMHMM2.0 at aa 40-62 and 66-88 522373016353 HMMPfam hit to PF03703, Bacterial membrane flanked domain, score 1.1e-14 522373016354 Predicted membrane protein [Function unknown]; Region: COG3428 522373016355 Bacterial PH domain; Region: DUF304; pfam03703 522373016356 Bacterial PH domain; Region: DUF304; pfam03703 522373016357 Bacterial PH domain; Region: DUF304; pfam03703 522373016358 5 probable transmembrane helices predicted for Smlt4170 by TMHMM2.0 at aa 55-77, 190-212, 241-263, 376-395 and 399-418 522373016359 HMMPfam hit to PF03703, Bacterial membrane flanked domain, score 6.8e-20 522373016360 HMMPfam hit to PF03703, Bacterial membrane flanked domain, score 1.2e-16 522373016361 HMMPfam hit to PF03703, Bacterial membrane flanked domain, score 2.5e-10 522373016362 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 522373016363 HMMPfam hit to PF04464, CDP-Glycerol:Poly(glycerophosphate) gl, score 2.6e-07 522373016364 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 522373016365 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 522373016366 putative metal binding site; other site 522373016367 HMMPfam hit to PF00535, Glycosyl transferase family, score 3.5e-19 522373016368 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 522373016369 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 522373016370 HMMPfam hit to PF00534, Glycosyl transferases group, score 6.6e-05 522373016371 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 522373016372 O-Antigen ligase; Region: Wzy_C; pfam04932 522373016373 10 probable transmembrane helices predicted for Smlt4174 by TMHMM2.0 at aa 10-32, 39-61, 71-93, 122-144, 159-181, 188-205, 210-227, 234-253, 339-361 and 373-395 522373016374 HMMPfam hit to PF04932, O-Antigen Polymerase, score 2.1e-11 522373016375 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 522373016376 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 522373016377 11 probable transmembrane helices predicted for Smlt4175 by TMHMM2.0 at aa 12-31, 80-102, 138-157, 167-189, 210-232, 267-289, 302-321, 326-348, 355-377, 397-419 and 424-446 522373016378 HMMPfam hit to PF02366, Dolichyl-phosphate-mannose-protein mannosylt, score 4.7e-05 522373016379 16S rRNA methyltransferase B; Provisional; Region: PRK10901 522373016380 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 522373016381 putative RNA binding site [nucleotide binding]; other site 522373016382 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 522373016383 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 1.8e-71 522373016384 HMMPfam hit to PF01029, NusB family, score 3.3e-19 522373016385 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 522373016386 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 522373016387 putative active site [active] 522373016388 substrate binding site [chemical binding]; other site 522373016389 putative cosubstrate binding site; other site 522373016390 catalytic site [active] 522373016391 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 522373016392 substrate binding site [chemical binding]; other site 522373016393 HMMPfam hit to PF02911, Formyl transferase, C-terminal domain, score 9.7e-34 522373016394 HMMPfam hit to PF00551, Formyl transferase, score 2.3e-51 522373016395 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 522373016396 active site 522373016397 catalytic residues [active] 522373016398 metal binding site [ion binding]; metal-binding site 522373016399 HMMPfam hit to PF01327, Polypeptide deformylase, score 7.7e-64 522373016400 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 522373016401 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 522373016402 HMMPfam hit to PF01476, LysM domain, score 2.3e-13 522373016403 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 522373016404 DNA protecting protein DprA; Region: dprA; TIGR00732 522373016405 HMMPfam hit to PF02481, SMF family, score 5.3e-81 522373016406 hypothetical protein; Validated; Region: PRK03430 522373016407 HMMPfam hit to PF04361, Protein of unknown function (DUF494), score 1e-102 522373016408 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 522373016409 Pilin (bacterial filament); Region: Pilin; pfam00114 522373016410 1 probable transmembrane helix predicted for Smlt4182 by TMHMM2.0 at aa 116-138 522373016411 HMMPfam hit to PF00114, Pilin (bacterial filament), score 0.00012 522373016412 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 522373016413 RDD family; Region: RDD; pfam06271 522373016414 HMMPfam hit to PF06271, RDD family, score 7.2e-38 522373016415 4 probable transmembrane helices predicted for Smlt4183 by TMHMM2.0 at aa 134-153, 168-190, 221-243 and 283-305 522373016416 DNA topoisomerase I; Provisional; Region: PRK08780 522373016417 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 522373016418 active site 522373016419 interdomain interaction site; other site 522373016420 putative metal-binding site [ion binding]; other site 522373016421 nucleotide binding site [chemical binding]; other site 522373016422 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 522373016423 domain I; other site 522373016424 DNA binding groove [nucleotide binding] 522373016425 phosphate binding site [ion binding]; other site 522373016426 domain II; other site 522373016427 domain III; other site 522373016428 nucleotide binding site [chemical binding]; other site 522373016429 catalytic site [active] 522373016430 domain IV; other site 522373016431 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 522373016432 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 522373016433 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 522373016434 HMMPfam hit to PF01751, Toprim domain, score 1.4e-32 522373016435 HMMPfam hit to PF01131, DNA topoisomerase, score 1.9e-168 522373016436 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 522373016437 HMMPfam hit to PF01300, yrdC domain, score 7.3e-48 522373016438 tropinone reductase; Provisional; Region: PRK09242 522373016439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373016440 NAD(P) binding site [chemical binding]; other site 522373016441 active site 522373016442 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.3e-21 522373016443 1 probable transmembrane helix predicted for Smlt4188 by TMHMM2.0 at aa 13-35 522373016444 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 522373016445 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 522373016446 tandem repeat interface [polypeptide binding]; other site 522373016447 oligomer interface [polypeptide binding]; other site 522373016448 active site residues [active] 522373016449 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 522373016450 tandem repeat interface [polypeptide binding]; other site 522373016451 oligomer interface [polypeptide binding]; other site 522373016452 active site residues [active] 522373016453 HMMPfam hit to PF01343, Peptidase family S49, score 4.2e-60 522373016454 HMMPfam hit to PF01343, Peptidase family S49, score 4.1e-16 522373016455 1 probable transmembrane helix predicted for Smlt4190 by TMHMM2.0 at aa 56-78 522373016456 multidrug efflux protein; Reviewed; Region: PRK01766 522373016457 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 522373016458 cation binding site [ion binding]; other site 522373016459 11 probable transmembrane helices predicted for Smlt4191 by TMHMM2.0 at aa 15-37, 50-72, 97-119, 161-183, 198-217, 246-268, 283-305, 318-340, 345-367, 394-416 and 420-439 522373016460 HMMPfam hit to PF01554, MatE, score 1.7e-32 522373016461 HMMPfam hit to PF01554, MatE, score 2.1e-18 522373016462 1 probable transmembrane helix predicted for Smlt4193 by TMHMM2.0 at aa 214-236 522373016463 primosome assembly protein PriA; Validated; Region: PRK05580 522373016464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373016465 ATP binding site [chemical binding]; other site 522373016466 putative Mg++ binding site [ion binding]; other site 522373016467 helicase superfamily c-terminal domain; Region: HELICc; smart00490 522373016468 nucleotide binding region [chemical binding]; other site 522373016469 ATP-binding site [chemical binding]; other site 522373016470 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 3.2e-08 522373016471 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.5e-25 522373016472 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.4e-05 522373016473 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 522373016474 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 522373016475 putative C-terminal domain interface [polypeptide binding]; other site 522373016476 putative GSH binding site (G-site) [chemical binding]; other site 522373016477 putative dimer interface [polypeptide binding]; other site 522373016478 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 522373016479 putative N-terminal domain interface [polypeptide binding]; other site 522373016480 putative dimer interface [polypeptide binding]; other site 522373016481 putative substrate binding pocket (H-site) [chemical binding]; other site 522373016482 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 1.8e-13 522373016483 Uncharacterized conserved protein [Function unknown]; Region: COG1432 522373016484 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 522373016485 putative metal binding site [ion binding]; other site 522373016486 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 522373016487 HMMPfam hit to PF01936, Protein of unknown function DUF88, score 4.9e-06 522373016488 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 522373016489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 522373016490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 522373016491 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.1e-05 522373016492 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 1.2e-19 522373016493 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 2.3e-05 522373016494 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 6.5e-16 522373016495 1 probable transmembrane helix predicted for Smlt4197 by TMHMM2.0 at aa 368-390 522373016496 1 probable transmembrane helix predicted for Smlt4198 by TMHMM2.0 at aa 21-43 522373016497 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 522373016498 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 522373016499 GIY-YIG motif/motif A; other site 522373016500 putative active site [active] 522373016501 putative metal binding site [ion binding]; other site 522373016502 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 3.5e-13 522373016503 7 probable transmembrane helices predicted for Smlt4202 by TMHMM2.0 at aa 20-42, 49-71, 84-101, 108-130, 134-156, 168-187 and 191-209 522373016504 Predicted membrane protein [Function unknown]; Region: COG2860 522373016505 UPF0126 domain; Region: UPF0126; pfam03458 522373016506 UPF0126 domain; Region: UPF0126; pfam03458 522373016507 HMMPfam hit to PF03458, UPF0126 domain, score 6.9e-33 522373016508 HMMPfam hit to PF03458, UPF0126 domain, score 6.9e-25 522373016509 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 522373016510 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 522373016511 HMMPfam hit to PF00793, DAHP synthetase I family, score 9.4e-152 522373016512 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 522373016513 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 522373016514 MarR family; Region: MarR_2; pfam12802 522373016515 HMMPfam hit to PF01047, MarR family, score 8.4e-15 522373016516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373016517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373016518 dimer interface [polypeptide binding]; other site 522373016519 phosphorylation site [posttranslational modification] 522373016520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373016521 ATP binding site [chemical binding]; other site 522373016522 Mg2+ binding site [ion binding]; other site 522373016523 G-X-G motif; other site 522373016524 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.5e-26 522373016525 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.2e-12 522373016526 HMMPfam hit to PF00672, HAMP domain, score 1.6e-09 522373016527 2 probable transmembrane helices predicted for Smlt4208 by TMHMM2.0 at aa 4-21 and 155-174 522373016528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373016529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373016530 active site 522373016531 phosphorylation site [posttranslational modification] 522373016532 intermolecular recognition site; other site 522373016533 dimerization interface [polypeptide binding]; other site 522373016534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373016535 DNA binding site [nucleotide binding] 522373016536 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 7.4e-22 522373016537 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.3e-33 522373016538 Aspartyl protease; Region: Asp_protease_2; pfam13650 522373016539 inhibitor binding site; inhibition site 522373016540 catalytic motif [active] 522373016541 Catalytic residue [active] 522373016542 Active site flap [active] 522373016543 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 522373016544 inhibitor binding site; inhibition site 522373016545 catalytic motif [active] 522373016546 Catalytic residue [active] 522373016547 Active site flap [active] 522373016548 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 522373016549 Beta-lactamase; Region: Beta-lactamase; pfam00144 522373016550 HMMPfam hit to PF00144, Beta-lactamase, score 6.6e-29 522373016551 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 522373016552 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 522373016553 ring oligomerisation interface [polypeptide binding]; other site 522373016554 ATP/Mg binding site [chemical binding]; other site 522373016555 stacking interactions; other site 522373016556 hinge regions; other site 522373016557 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 2.5e-193 522373016558 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 522373016559 oligomerisation interface [polypeptide binding]; other site 522373016560 mobile loop; other site 522373016561 roof hairpin; other site 522373016562 HMMPfam hit to PF00166, Chaperonin 10 Kd subunit, score 7.6e-48 522373016563 Bacterial Ig-like domain; Region: Big_5; pfam13205 522373016564 Endonuclease I; Region: Endonuclease_1; pfam04231 522373016565 HMMPfam hit to PF04231, Endonuclease I, score 2.6e-14 522373016566 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 522373016567 HMMPfam hit to PF03091, CutA1 divalent ion tolerance protein, score 6.8e-35 522373016568 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 522373016569 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 522373016570 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 522373016571 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 522373016572 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 522373016573 8 probable transmembrane helices predicted for Smlt4218 by TMHMM2.0 at aa 393-415, 436-458, 478-500, 521-543, 553-575, 588-606, 616-633 and 640-662 522373016574 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 522373016575 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373016576 catalytic residues [active] 522373016577 1 probable transmembrane helix predicted for Smlt4219 by TMHMM2.0 at aa 7-24 522373016578 HMMPfam hit to PF08534, Redoxin, score 4e-14 522373016579 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 522373016580 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 522373016581 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.0059 522373016582 3 probable transmembrane helices predicted for Smlt4220 by TMHMM2.0 at aa 9-31, 138-160 and 181-203 522373016583 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.018 522373016584 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.75 522373016585 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 522373016586 Flavodoxin; Region: Flavodoxin_1; pfam00258 522373016587 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 522373016588 FAD binding pocket [chemical binding]; other site 522373016589 FAD binding motif [chemical binding]; other site 522373016590 catalytic residues [active] 522373016591 NAD binding pocket [chemical binding]; other site 522373016592 phosphate binding motif [ion binding]; other site 522373016593 beta-alpha-beta structure motif; other site 522373016594 1 probable transmembrane helix predicted for Smlt4221 by TMHMM2.0 at aa 83-105 522373016595 HMMPfam hit to PF00258, Flavodoxin, score 1.4e-30 522373016596 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 2e-12 522373016597 HAMP domain; Region: HAMP; pfam00672 522373016598 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 522373016599 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373016600 dimer interface [polypeptide binding]; other site 522373016601 putative CheW interface [polypeptide binding]; other site 522373016602 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.1e-68 522373016603 HMMPfam hit to PF00672, HAMP domain, score 1.7e-09 522373016604 2 probable transmembrane helices predicted for Smlt4222 by TMHMM2.0 at aa 360-382 and 623-645 522373016605 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 522373016606 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 522373016607 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 0.00028 522373016608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373016609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373016610 active site 522373016611 phosphorylation site [posttranslational modification] 522373016612 intermolecular recognition site; other site 522373016613 dimerization interface [polypeptide binding]; other site 522373016614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373016615 DNA binding residues [nucleotide binding] 522373016616 dimerization interface [polypeptide binding]; other site 522373016617 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 2.9e-19 522373016618 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.7e-34 522373016619 Histidine kinase; Region: HisKA_3; pfam07730 522373016620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373016621 ATP binding site [chemical binding]; other site 522373016622 Mg2+ binding site [ion binding]; other site 522373016623 G-X-G motif; other site 522373016624 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.1e-05 522373016625 HMMPfam hit to PF07730, Histidine kinase, score 1.7e-14 522373016626 5 probable transmembrane helices predicted for Smlt4225 by TMHMM2.0 at aa 7-29, 34-56, 63-85, 100-122 and 129-151 522373016627 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 522373016628 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 522373016629 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 522373016630 HMMPfam hit to PF03055, Retinal pigment epithelial membrane protein, score 4.1e-45 522373016631 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 522373016632 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 522373016633 substrate binding pocket [chemical binding]; other site 522373016634 membrane-bound complex binding site; other site 522373016635 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 522373016636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373016637 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 522373016638 dimerization interface [polypeptide binding]; other site 522373016639 substrate binding pocket [chemical binding]; other site 522373016640 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.8e-29 522373016641 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.6e-07 522373016642 T5orf172 domain; Region: T5orf172; pfam10544 522373016643 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 522373016644 dimer interface [polypeptide binding]; other site 522373016645 active site 522373016646 HMMPfam hit to PF00245, Alkaline phosphatase, score 4.6e-10 522373016647 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 522373016648 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 522373016649 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 1.7e-47 522373016650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 522373016651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 522373016652 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2.6e-11 522373016653 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 522373016654 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 522373016655 HMMPfam hit to PF02525, Flavodoxin-like fold, score 1.5e-38 522373016656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 522373016657 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 522373016658 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 522373016659 tetramer interface [polypeptide binding]; other site 522373016660 active site 522373016661 Mg2+/Mn2+ binding site [ion binding]; other site 522373016662 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 522373016663 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 522373016664 Dehydroquinase class II; Region: DHquinase_II; pfam01220 522373016665 active site 522373016666 trimer interface [polypeptide binding]; other site 522373016667 dimer interface [polypeptide binding]; other site 522373016668 HMMPfam hit to PF01220, Dehydroquinase class II, score 2.9e-72 522373016669 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 522373016670 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 522373016671 carboxyltransferase (CT) interaction site; other site 522373016672 biotinylation site [posttranslational modification]; other site 522373016673 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 1.4e-31 522373016674 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 522373016675 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 522373016676 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 522373016677 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 522373016678 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 2.8e-52 522373016679 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 7.9e-119 522373016680 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 9.9e-62 522373016681 1 probable transmembrane helix predicted for Smlt4242 by TMHMM2.0 at aa 12-34 522373016682 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 522373016683 HMMPfam hit to PF06325, Ribosomal protein L11 methyltransfera, score 4.4e-147 522373016684 HMMPfam hit to PF08242, Methyltransferase domain, score 8.4e-07 522373016685 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 522373016686 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 522373016687 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 522373016688 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis family, score 6.4e-15 522373016689 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 522373016690 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 522373016691 HMMPfam hit to PF01148, Cytidylyltransferase family, score 1.6e-85 522373016692 7 probable transmembrane helices predicted for Smlt4247 by TMHMM2.0 at aa 15-37, 68-90, 105-127, 129-151, 166-188, 195-217 and 258-280 522373016693 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 522373016694 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 522373016695 putative acyl-acceptor binding pocket; other site 522373016696 HMMPfam hit to PF01553, Acyltransferase, score 1e-11 522373016697 2 probable transmembrane helices predicted for Smlt4249 by TMHMM2.0 at aa 29-51 and 121-143 522373016698 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 522373016699 active site 522373016700 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 522373016701 active site 522373016702 catalytic residues [active] 522373016703 HMMPfam hit to PF00782, Dual specificity phosphatase, catalytic doma, score 4.4e-06 522373016704 8 probable transmembrane helices predicted for Smlt4250 by TMHMM2.0 at aa 21-43, 61-83, 96-114, 138-155, 162-184, 188-205, 225-247 and 252-274 522373016705 HMMPfam hit to PF01569, PAP2 superfamily, score 0.00012 522373016706 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 522373016707 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 522373016708 Putative methyltransferase; Region: Methyltransf_20; pfam12147 522373016709 Methyltransferase domain; Region: Methyltransf_31; pfam13847 522373016710 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 522373016711 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 4.2e-13 522373016712 4 probable transmembrane helices predicted for Smlt4252 by TMHMM2.0 at aa 100-122, 126-148, 193-215 and 243-265 522373016713 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 522373016714 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 522373016715 purine monophosphate binding site [chemical binding]; other site 522373016716 dimer interface [polypeptide binding]; other site 522373016717 putative catalytic residues [active] 522373016718 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 522373016719 HMMPfam hit to PF02142, MGS-like domain, score 6.4e-54 522373016720 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, score 1.8e-150 522373016721 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 522373016722 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 522373016723 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 522373016724 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 522373016725 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, N d, score 1.4e-59 522373016726 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP, score 3.7e-128 522373016727 HMMPfam hit to PF08442, ATP-grasp domain, score 0.0022 522373016728 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, C d, score 4.6e-38 522373016729 Predicted transcriptional regulator [Transcription]; Region: COG2944 522373016730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 522373016731 non-specific DNA binding site [nucleotide binding]; other site 522373016732 salt bridge; other site 522373016733 sequence-specific DNA binding site [nucleotide binding]; other site 522373016734 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 522373016735 HMMPfam hit to PF06296, Protein of unknown function (DUF1044), score 4.4e-35 522373016736 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 522373016737 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 522373016738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373016739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373016740 DNA binding residues [nucleotide binding] 522373016741 HMMPfam hit to PF04545, Sigma-70, region, score 5e-14 522373016742 HMMPfam hit to PF04542, Sigma-70 region, score 2.4e-22 522373016743 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 522373016744 ligand binding site [chemical binding]; other site 522373016745 active site 522373016746 UGI interface [polypeptide binding]; other site 522373016747 catalytic site [active] 522373016748 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 1e-74 522373016749 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373016750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373016751 active site 522373016752 phosphorylation site [posttranslational modification] 522373016753 intermolecular recognition site; other site 522373016754 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373016755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373016756 active site 522373016757 phosphorylation site [posttranslational modification] 522373016758 intermolecular recognition site; other site 522373016759 dimerization interface [polypeptide binding]; other site 522373016760 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.4e-14 522373016761 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.8e-06 522373016762 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 522373016763 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 522373016764 HMMPfam hit to PF02687, Predicted permease, score 2.5e-22 522373016765 4 probable transmembrane helices predicted for Smlt4261 by TMHMM2.0 at aa 38-60, 180-202, 239-261 and 281-303 522373016766 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 522373016767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373016768 Walker A/P-loop; other site 522373016769 ATP binding site [chemical binding]; other site 522373016770 Q-loop/lid; other site 522373016771 ABC transporter signature motif; other site 522373016772 Walker B; other site 522373016773 D-loop; other site 522373016774 H-loop/switch region; other site 522373016775 HMMPfam hit to PF00005, ABC transporter score 2.1e-56 522373016776 helicase 45; Provisional; Region: PTZ00424 522373016777 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 522373016778 ATP binding site [chemical binding]; other site 522373016779 Mg++ binding site [ion binding]; other site 522373016780 motif III; other site 522373016781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373016782 nucleotide binding region [chemical binding]; other site 522373016783 ATP-binding site [chemical binding]; other site 522373016784 Protein of unknown function (DUF3628); Region: DUF3628; pfam12300 522373016785 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.9e-31 522373016786 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.8e-66 522373016787 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 522373016788 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 522373016789 catalytic residues [active] 522373016790 HMMPfam hit to PF00085, Thioredoxin, score 1.6e-43 522373016791 transcription termination factor Rho; Provisional; Region: rho; PRK09376 522373016792 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 522373016793 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 522373016794 RNA binding site [nucleotide binding]; other site 522373016795 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 522373016796 multimer interface [polypeptide binding]; other site 522373016797 Walker A motif; other site 522373016798 ATP binding site [chemical binding]; other site 522373016799 Walker B motif; other site 522373016800 HMMPfam hit to PF07498, Rho termination factor, N-terminal domai, score 1.2e-13 522373016801 HMMPfam hit to PF07497, Rho termination factor, RNA-binding doma, score 7.8e-54 522373016802 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleoti, score 1.2e-74 522373016803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 522373016804 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373016805 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373016806 metal binding site [ion binding]; metal-binding site 522373016807 active site 522373016808 I-site; other site 522373016809 3 probable transmembrane helices predicted for Smlt4266 by TMHMM2.0 at aa 10-32, 245-267 and 282-304 522373016810 HMMPfam hit to PF00990, GGDEF domain, score 1.6e-54 522373016811 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373016812 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 6.3e-06 522373016813 1 probable transmembrane helix predicted for Smlt4267 by TMHMM2.0 at aa 43-60 522373016814 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 522373016815 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 522373016816 HMMPfam hit to PF06315, Isocitrate dehydrogenase kinase/phosphatase, score 0 522373016817 HMMPfam hit to PF03259, Roadblock/LC7 domain, score 7.3e-07 522373016818 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 522373016819 G1 box; other site 522373016820 GTP/Mg2+ binding site [chemical binding]; other site 522373016821 G2 box; other site 522373016822 Switch I region; other site 522373016823 G3 box; other site 522373016824 Switch II region; other site 522373016825 G4 box; other site 522373016826 G5 box; other site 522373016827 HMMPfam hit to PF03029, Conserved hypothetical ATP binding protein, score 4.4e-10 522373016828 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 522373016829 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 522373016830 HMMPfam hit to PF03971, Monomeric isocitrate dehydrogenase, score 0 522373016831 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 522373016832 HMMPfam hit to PF01476, LysM domain, score 9.2e-12 522373016833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 522373016834 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 522373016835 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 522373016836 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 1.4e-06 522373016837 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 522373016838 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 522373016839 metal binding site [ion binding]; metal-binding site 522373016840 putative dimer interface [polypeptide binding]; other site 522373016841 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 6.2e-54 522373016842 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 3e-05 522373016843 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373016844 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373016845 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373016846 1 probable transmembrane helix predicted for Smlt4279 by TMHMM2.0 at aa 31-50 522373016847 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.6e-14 522373016848 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 522373016849 Protein export membrane protein; Region: SecD_SecF; cl14618 522373016850 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373016851 10 probable transmembrane helices predicted for Smlt4280 by TMHMM2.0 at aa 7-29, 332-351, 358-380, 427-449, 461-483, 532-551, 897-919, 939-961, 991-1013 and 1028-1050 522373016852 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 522373016853 Protein export membrane protein; Region: SecD_SecF; cl14618 522373016854 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373016855 11 probable transmembrane helices predicted for Smlt4281 by TMHMM2.0 at aa 15-37, 338-360, 364-386, 393-415, 435-457, 469-491, 531-553, 863-885, 905-927, 958-980 and 1000-1022 522373016856 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 522373016857 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 522373016858 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 522373016859 HMMPfam hit to PF05976, Bacterial membrane protein of unknown functi, score 0 522373016860 9 probable transmembrane helices predicted for Smlt4282 by TMHMM2.0 at aa 67-84, 88-105, 117-136, 140-159, 164-181, 196-218, 445-467, 517-534 and 541-563 522373016861 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 522373016862 classical (c) SDRs; Region: SDR_c; cd05233 522373016863 NAD(P) binding site [chemical binding]; other site 522373016864 active site 522373016865 HMMPfam hit to PF00106, short chain dehydrogenase, score 4.4e-22 522373016866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373016867 putative substrate translocation pore; other site 522373016868 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 522373016869 putative acyl-acceptor binding pocket; other site 522373016870 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.5e-16 522373016871 9 probable transmembrane helices predicted for Smlt4284 by TMHMM2.0 at aa 60-82, 103-125, 177-199, 242-264, 274-293, 302-324, 348-370, 383-405 and 420-442 522373016872 HMMPfam hit to PF01553, Acyltransferase, score 3.7e-29 522373016873 Interferon-induced transmembrane protein; Region: CD225; pfam04505 522373016874 HMMPfam hit to PF04505, Interferon-induced transmembrane protein, score 0.0019 522373016875 2 probable transmembrane helices predicted for Smlt4285 by TMHMM2.0 at aa 18-40 and 61-83 522373016876 Interferon-induced transmembrane protein; Region: CD225; pfam04505 522373016877 HMMPfam hit to PF04505, Interferon-induced transmembrane protein, score 0.00019 522373016878 2 probable transmembrane helices predicted for Smlt4286 by TMHMM2.0 at aa 12-34 and 59-81 522373016879 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 522373016880 3 probable transmembrane helices predicted for Smlt4287 by TMHMM2.0 at aa 13-30, 75-97 and 110-132 522373016881 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 522373016882 6 probable transmembrane helices predicted for Smlt4289 by TMHMM2.0 at aa 5-27, 48-70, 74-93, 145-167, 189-211 and 272-294 522373016883 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 522373016884 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 522373016885 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 522373016886 putative NADH binding site [chemical binding]; other site 522373016887 putative active site [active] 522373016888 nudix motif; other site 522373016889 putative metal binding site [ion binding]; other site 522373016890 HMMPfam hit to PF00293, NUDIX domain, score 6.8e-20 522373016891 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 522373016892 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 7.5e-38 522373016893 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 522373016894 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 522373016895 HMMPfam hit to PF04519, Protein of unknown function, DUF583, score 3.2e-32 522373016896 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 522373016897 1 probable transmembrane helix predicted for Smlt4293 by TMHMM2.0 at aa 26-48 522373016898 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 522373016899 2 probable transmembrane helices predicted for Smlt4294 by TMHMM2.0 at aa 32-54 and 186-208 522373016900 Response regulator receiver domain; Region: Response_reg; pfam00072 522373016901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373016902 active site 522373016903 phosphorylation site [posttranslational modification] 522373016904 intermolecular recognition site; other site 522373016905 dimerization interface [polypeptide binding]; other site 522373016906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373016907 metal binding site [ion binding]; metal-binding site 522373016908 active site 522373016909 I-site; other site 522373016910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 522373016911 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.3e-31 522373016912 HMMPfam hit to PF00990, GGDEF domain, score 1.8e-05 522373016913 HMMPfam hit to PF00563, EAL domain, score 2.3e-12 522373016914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373016915 dimer interface [polypeptide binding]; other site 522373016916 phosphorylation site [posttranslational modification] 522373016917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373016918 ATP binding site [chemical binding]; other site 522373016919 Mg2+ binding site [ion binding]; other site 522373016920 G-X-G motif; other site 522373016921 Response regulator receiver domain; Region: Response_reg; pfam00072 522373016922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373016923 active site 522373016924 phosphorylation site [posttranslational modification] 522373016925 intermolecular recognition site; other site 522373016926 dimerization interface [polypeptide binding]; other site 522373016927 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 522373016928 putative binding surface; other site 522373016929 active site 522373016930 1 probable transmembrane helix predicted for Smlt4296 by TMHMM2.0 at aa 5-27 522373016931 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.3e-24 522373016932 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.6e-45 522373016933 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.9e-36 522373016934 HMMPfam hit to PF01627, Hpt domain, score 2.8e-16 522373016935 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 522373016936 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 522373016937 heme binding site [chemical binding]; other site 522373016938 ferroxidase pore; other site 522373016939 ferroxidase diiron center [ion binding]; other site 522373016940 HMMPfam hit to PF00210, Ferritin-like domain, score 1.9e-51 522373016941 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 522373016942 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 1.7e-17 522373016943 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 522373016944 putative active site [active] 522373016945 Ap4A binding site [chemical binding]; other site 522373016946 nudix motif; other site 522373016947 putative metal binding site [ion binding]; other site 522373016948 HMMPfam hit to PF00293, NUDIX domain, score 3.3e-24 522373016949 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 522373016950 HMMPfam hit to PF00380, Ribosomal protein S9/S16, score 8.1e-65 522373016951 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 522373016952 23S rRNA interface [nucleotide binding]; other site 522373016953 L3 interface [polypeptide binding]; other site 522373016954 HMMPfam hit to PF00572, Ribosomal protein L13, score 6.1e-75 522373016955 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 522373016956 diiron binding motif [ion binding]; other site 522373016957 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 522373016958 4 probable transmembrane helices predicted for Smlt4304 by TMHMM2.0 at aa 21-38, 48-65, 77-96 and 100-122 522373016959 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 5.7e-35 522373016960 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 522373016961 HMMPfam hit to PF02675, S-adenosylmethionine decarboxylase, score 8e-76 522373016962 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 522373016963 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 522373016964 ligand binding site [chemical binding]; other site 522373016965 flexible hinge region; other site 522373016966 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 522373016967 putative switch regulator; other site 522373016968 non-specific DNA interactions [nucleotide binding]; other site 522373016969 DNA binding site [nucleotide binding] 522373016970 sequence specific DNA binding site [nucleotide binding]; other site 522373016971 putative cAMP binding site [chemical binding]; other site 522373016972 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 9.4e-22 522373016973 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 5.4e-13 522373016974 7 probable transmembrane helices predicted for Smlt4307 by TMHMM2.0 at aa 7-29, 49-68, 75-97, 101-123, 171-193, 197-219 and 226-248 522373016975 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 1.1e-06 522373016976 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 522373016977 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.3e-05 522373016978 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 522373016979 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 522373016980 active site 522373016981 ribulose/triose binding site [chemical binding]; other site 522373016982 phosphate binding site [ion binding]; other site 522373016983 substrate (anthranilate) binding pocket [chemical binding]; other site 522373016984 product (indole) binding pocket [chemical binding]; other site 522373016985 HMMPfam hit to PF00218, Indole-3-glycerol phosphate synthase, score 6.6e-139 522373016986 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 522373016987 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 522373016988 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 522373016989 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 3.8e-124 522373016990 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 1.6e-13 522373016991 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 522373016992 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 522373016993 glutamine binding [chemical binding]; other site 522373016994 catalytic triad [active] 522373016995 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5.3e-86 522373016996 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 522373016997 HMMPfam hit to PF04402, Protein of unknown function (DUF541), score 6.3e-09 522373016998 anthranilate synthase component I; Provisional; Region: PRK13565 522373016999 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 522373017000 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 522373017001 HMMPfam hit to PF00425, chorismate binding enzyme, score 2e-164 522373017002 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 3.1e-39 522373017003 lipid kinase; Reviewed; Region: PRK13054 522373017004 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 522373017005 HMMPfam hit to PF00781, Diacylglycerol kinase catalytic domain (pres, score 8.5e-32 522373017006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 522373017007 Coenzyme A binding pocket [chemical binding]; other site 522373017008 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.9e-18 522373017009 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 522373017010 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 522373017011 substrate binding site [chemical binding]; other site 522373017012 hexamer interface [polypeptide binding]; other site 522373017013 metal binding site [ion binding]; metal-binding site 522373017014 HMMPfam hit to PF00834, Ribulose-phosphate 3 epimerase family, score 1.1e-139 522373017015 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 522373017016 HSP70 interaction site [polypeptide binding]; other site 522373017017 HMMPfam hit to PF00226, DnaJ domain, score 1.4e-12 522373017018 1 probable transmembrane helix predicted for Smlt4317 by TMHMM2.0 at aa 20-42 522373017019 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 522373017020 ATP binding site [chemical binding]; other site 522373017021 active site 522373017022 substrate binding site [chemical binding]; other site 522373017023 HMMPfam hit to PF01259, SAICAR synthetase, score 2.2e-112 522373017024 Protein of unknown function (DUF962); Region: DUF962; cl01879 522373017025 HMMPfam hit to PF06127, Protein of unknown function (DUF962), score 8.3e-62 522373017026 4 probable transmembrane helices predicted for Smlt4319 by TMHMM2.0 at aa 55-77, 92-114, 119-141 and 151-170 522373017027 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 522373017028 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 522373017029 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 522373017030 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 522373017031 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 522373017032 23 probable transmembrane helices predicted for Smlt4320 by TMHMM2.0 at aa 5-22, 29-51, 79-101, 114-136, 161-183, 204-221, 236-258, 271-293, 308-330, 366-388, 408-430, 462-484, 504-526, 567-589, 604-621, 628-650, 655-677, 690-712, 747-764, 784-806, 816-838, 850-872 and 892-914 522373017033 HMMPfam hit to PF00662, NADH-Ubiquinone oxidoreductase (complex, score 1.6e-06 522373017034 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex, score 1.1e-77 522373017035 HMMPfam hit to PF04039, Domain related to MnhB subunit of Na+/H, score 3.5e-30 522373017036 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 522373017037 HMMPfam hit to PF00420, NADH-ubiquinone/plastoquinone oxidoreduct, score 7.7e-12 522373017038 3 probable transmembrane helices predicted for Smlt4321 by TMHMM2.0 at aa 4-21, 28-50 and 72-94 522373017039 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 522373017040 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 522373017041 14 probable transmembrane helices predicted for Smlt4322 by TMHMM2.0 at aa 4-22, 35-57, 80-102, 109-126, 130-152, 159-181, 210-232, 239-261, 281-298, 305-324, 328-350, 376-398, 408-430 and 458-480 522373017042 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 2.6e-15 522373017043 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 522373017044 2 probable transmembrane helices predicted for Smlt4323 by TMHMM2.0 at aa 7-28 and 32-54 522373017045 HMMPfam hit to PF01899, Na+/H+ ion antiporter subunit, score 5.6e-06 522373017046 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 522373017047 3 probable transmembrane helices predicted for Smlt4324 by TMHMM2.0 at aa 5-27, 39-61 and 66-88 522373017048 HMMPfam hit to PF04066, Multiple resistance and pH regulation prote, score 5e-18 522373017049 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 522373017050 HMMPfam hit to PF03334, Na+/H+ antiporter subunit, score 7.6e-18 522373017051 3 probable transmembrane helices predicted for Smlt4325 by TMHMM2.0 at aa 7-28, 43-62 and 75-97 522373017052 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 522373017053 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 522373017054 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 522373017055 9 probable transmembrane helices predicted for Smlt4326 by TMHMM2.0 at aa 2-21, 77-99, 106-128, 133-150, 171-193, 203-225, 238-260, 270-289 and 301-320 522373017056 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 2.9e-29 522373017057 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 4.3e-25 522373017058 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 522373017059 HMMPfam hit to PF04209, homogentisate 1,2-dioxygenase, score 2.6e-276 522373017060 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 522373017061 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 522373017062 dimer interface [polypeptide binding]; other site 522373017063 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 522373017064 active site 522373017065 Fe binding site [ion binding]; other site 522373017066 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 1.9e-11 522373017067 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 522373017068 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 522373017069 HMMPfam hit to PF06250, Protein of unknown function (DUF1016), score 6.3e-180 522373017070 3 probable transmembrane helices predicted for Smlt4333 by TMHMM2.0 at aa 295-317, 375-397 and 404-426 522373017071 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 522373017072 POT family; Region: PTR2; cl17359 522373017073 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 522373017074 14 probable transmembrane helices predicted for Smlt4335 by TMHMM2.0 at aa 53-75, 85-107, 116-135, 145-167, 176-198, 213-235, 248-270, 274-293, 306-323, 350-372, 385-407, 417-439, 451-473 and 488-510 522373017075 HMMPfam hit to PF00854, POT family, score 6e-42 522373017076 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 522373017077 HMMPfam hit to PF03301, Tryptophan 2,3-dioxygenase, score 4.1e-72 522373017078 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 522373017079 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 522373017080 TPP-binding site [chemical binding]; other site 522373017081 tetramer interface [polypeptide binding]; other site 522373017082 heterodimer interface [polypeptide binding]; other site 522373017083 phosphorylation loop region [posttranslational modification] 522373017084 HMMPfam hit to PF00676, Dehydrogenase E1 component, score 2.3e-80 522373017085 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 522373017086 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 522373017087 alpha subunit interface [polypeptide binding]; other site 522373017088 TPP binding site [chemical binding]; other site 522373017089 heterodimer interface [polypeptide binding]; other site 522373017090 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 522373017091 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 2.7e-66 522373017092 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 7.5e-52 522373017093 Variant SH3 domain; Region: SH3_2; pfam07653 522373017094 Src Homology 3 domain superfamily; Region: SH3; cl17036 522373017095 peptide ligand binding site [polypeptide binding]; other site 522373017096 HMMPfam hit to PF07653, Variant SH3 domain, score 8.1e-12 522373017097 HMMPfam hit to PF00018, SH3 domain, score 0.0039 522373017098 HMMPfam hit to PF07653, Variant SH3 domain, score 8.3e-05 522373017099 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 522373017100 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 522373017101 E3 interaction surface; other site 522373017102 lipoyl attachment site [posttranslational modification]; other site 522373017103 e3 binding domain; Region: E3_binding; pfam02817 522373017104 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 522373017105 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 9.5e-20 522373017106 HMMPfam hit to PF02817, e3 binding domain, score 3.4e-09 522373017107 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 5.6e-52 522373017108 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 522373017109 putative dimer interface [polypeptide binding]; other site 522373017110 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 7.2e-12 522373017111 HTH domain; Region: HTH_11; pfam08279 522373017112 Predicted transcriptional regulator [Transcription]; Region: COG2378 522373017113 WYL domain; Region: WYL; pfam13280 522373017114 HMMPfam hit to PF02082, Transcriptional regulator, score 0.00084 522373017115 HMMPfam hit to PF08279, HTH domain, score 2.3e-19 522373017116 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 522373017117 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 522373017118 NAD binding site [chemical binding]; other site 522373017119 active site 522373017120 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fa, score 0.00058 522373017121 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindin, score 0.0019 522373017122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373017123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373017124 metal binding site [ion binding]; metal-binding site 522373017125 active site 522373017126 I-site; other site 522373017127 HMMPfam hit to PF00990, GGDEF domain, score 2.1e-40 522373017128 Protein of unknown function (DUF808); Region: DUF808; pfam05661 522373017129 HMMPfam hit to PF05661, Protein of unknown function (DUF808), score 1.3e-163 522373017130 5 probable transmembrane helices predicted for Smlt4346 by TMHMM2.0 at aa 90-112, 160-179, 183-205, 238-260 and 275-297 522373017131 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 522373017132 ABC1 family; Region: ABC1; cl17513 522373017133 HMMPfam hit to PF03109, ABC1 family, score 1e-45 522373017134 2 probable transmembrane helices predicted for Smlt4347 by TMHMM2.0 at aa 494-513 and 528-550 522373017135 4 probable transmembrane helices predicted for Smlt4348 by TMHMM2.0 at aa 28-47, 52-72, 102-119 and 131-153 522373017136 phosphoglycerol transferase I; Provisional; Region: PRK12363 522373017137 Sulfatase; Region: Sulfatase; cl17466 522373017138 HMMPfam hit to PF00884, Sulfatase, score 8.2e-21 522373017139 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 522373017140 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 522373017141 Mechanosensitive ion channel; Region: MS_channel; pfam00924 522373017142 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 1.2e-49 522373017143 11 probable transmembrane helices predicted for Smlt4350 by TMHMM2.0 at aa 224-246, 270-292, 312-329, 350-369, 379-401, 435-457, 462-484, 526-548, 568-590, 611-633 and 643-665 522373017144 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 522373017145 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 522373017146 HMMPfam hit to PF08212, Lipocalin-like domain, score 1.1e-74 522373017147 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 522373017148 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 522373017149 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 8.8e-67 522373017150 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 522373017151 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 522373017152 1 probable transmembrane helix predicted for Smlt4358 by TMHMM2.0 at aa 21-43 522373017153 Predicted membrane protein [Function unknown]; Region: COG3212 522373017154 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 522373017155 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 522373017156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373017157 active site 522373017158 phosphorylation site [posttranslational modification] 522373017159 intermolecular recognition site; other site 522373017160 dimerization interface [polypeptide binding]; other site 522373017161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373017162 DNA binding site [nucleotide binding] 522373017163 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.1e-28 522373017164 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 7.3e-23 522373017165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373017166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373017167 ATP binding site [chemical binding]; other site 522373017168 Mg2+ binding site [ion binding]; other site 522373017169 G-X-G motif; other site 522373017170 1 probable transmembrane helix predicted for Smlt4361 by TMHMM2.0 at aa 12-34 522373017171 HMMPfam hit to PF00672, HAMP domain, score 0.00033 522373017172 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.6e-27 522373017173 Low molecular weight phosphatase family; Region: LMWPc; cl00105 522373017174 4 probable transmembrane helices predicted for Smlt4363 by TMHMM2.0 at aa 5-24, 31-48, 58-77 and 84-103 522373017175 arginine decarboxylase; Provisional; Region: PRK05354 522373017176 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 522373017177 dimer interface [polypeptide binding]; other site 522373017178 active site 522373017179 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 522373017180 catalytic residues [active] 522373017181 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 522373017182 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 1.2e-48 522373017183 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 7.6e-64 522373017184 spermidine synthase; Provisional; Region: PRK00811 522373017185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373017186 S-adenosylmethionine binding site [chemical binding]; other site 522373017187 HMMPfam hit to PF01564, Spermine/spermidine synthase, score 1.8e-83 522373017188 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 522373017189 2 probable transmembrane helices predicted for Smlt4366 by TMHMM2.0 at aa 5-22 and 280-301 522373017190 HMMPfam hit to PF05118, Aspartyl/Asparaginyl beta-hydroxylase, score 3.2e-80 522373017191 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 522373017192 active site 522373017193 ATP binding site [chemical binding]; other site 522373017194 HMMPfam hit to PF01163, RIO1 family, score 0.00012 522373017195 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 522373017196 Winged helix-turn helix; Region: HTH_29; pfam13551 522373017197 Integrase core domain; Region: rve; pfam00665 522373017198 Integrase core domain; Region: rve_3; pfam13683 522373017199 HMMPfam hit to PF00665, Integrase core domain, score 8.2e-34 522373017200 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 522373017201 Nitrogen regulatory protein P-II; Region: P-II; smart00938 522373017202 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 2.2e-66 522373017203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 522373017204 HMMPfam hit to PF04380, Protein of unknown function (DUF526), score 4.1e-32 522373017205 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 522373017206 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 522373017207 Protein of unknown function (DUF998); Region: DUF998; pfam06197 522373017208 6 probable transmembrane helices predicted for Smlt4378 by TMHMM2.0 at aa 7-29, 51-73, 80-102, 107-129, 136-155 and 165-187 522373017209 1 probable transmembrane helix predicted for Smlt4381 by TMHMM2.0 at aa 5-24 522373017210 Protein of unknown function (DUF1629); Region: DUF1629; pfam07791 522373017211 HMMPfam hit to PF07791, Protein of unknown function (DUF1629), score 1.2e-39 522373017212 Predicted amidohydrolase [General function prediction only]; Region: COG0388 522373017213 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 522373017214 active site 522373017215 catalytic triad [active] 522373017216 dimer interface [polypeptide binding]; other site 522373017217 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 2.9e-13 522373017218 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 522373017219 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 522373017220 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 522373017221 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 522373017222 HMMPfam hit to PF01078, Magnesium chelatase, subunit ChlI, score 8.6e-144 522373017223 HMMPfam hit to PF07728, ATPase family associated with various ce, score 0.00011 522373017224 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373017225 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373017226 HMMPfam hit to PF00593, TonB dependent receptor, score 1.3e-20 522373017227 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.2e-06 522373017228 sugar phosphate phosphatase; Provisional; Region: PRK10513 522373017229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373017230 active site 522373017231 motif I; other site 522373017232 motif II; other site 522373017233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 522373017234 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 3.1e-05 522373017235 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 1e-80 522373017236 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.6e-09 522373017237 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 522373017238 HMMPfam hit to PF06055, Exopolysaccharide synthesis, ExoD, score 5.9e-43 522373017239 3 probable transmembrane helices predicted for Smlt4391 by TMHMM2.0 at aa 103-125, 186-208 and 228-250 522373017240 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 522373017241 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 522373017242 Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059 522373017243 calcium binding site 1 [ion binding]; other site 522373017244 active site 522373017245 catalytic triad [active] 522373017246 calcium binding site 2 [ion binding]; other site 522373017247 calcium binding site 3 [ion binding]; other site 522373017248 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 522373017249 HMMPfam hit to PF00082, Subtilase family, score 6.2e-30 522373017250 HMMPfam hit to PF01483, Proprotein convertase P-domain, score 3.1e-15 522373017251 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 522373017252 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 522373017253 Cu(I) binding site [ion binding]; other site 522373017254 HMMPfam hit to PF02630, SCO1/SenC, score 1.8e-17 522373017255 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 522373017256 3 probable transmembrane helices predicted for Smlt4398 by TMHMM2.0 at aa 25-47, 52-74 and 84-106 522373017257 HMMPfam hit to PF03626, Prokaryotic Cytochrome C oxidase subunit IV, score 1.1e-39 522373017258 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 522373017259 Subunit I/III interface [polypeptide binding]; other site 522373017260 Subunit III/IV interface [polypeptide binding]; other site 522373017261 HMMPfam hit to PF00510, Cytochrome c oxidase subunit III, score 0.00023 522373017262 5 probable transmembrane helices predicted for Smlt4399 by TMHMM2.0 at aa 37-59, 74-96, 103-125, 145-167 and 188-210 522373017263 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 522373017264 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 522373017265 D-pathway; other site 522373017266 Putative ubiquinol binding site [chemical binding]; other site 522373017267 Low-spin heme (heme b) binding site [chemical binding]; other site 522373017268 Putative water exit pathway; other site 522373017269 Binuclear center (heme o3/CuB) [ion binding]; other site 522373017270 K-pathway; other site 522373017271 Putative proton exit pathway; other site 522373017272 14 probable transmembrane helices predicted for Smlt4400 by TMHMM2.0 at aa 15-37, 57-79, 105-127, 140-162, 191-213, 233-255, 275-297, 310-332, 347-369, 382-404, 424-446, 458-480, 495-517 and 589-611 522373017273 HMMPfam hit to PF00115, Cytochrome C and Quinol oxidase polypeptide, score 7.3e-248 522373017274 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 522373017275 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 522373017276 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 522373017277 HMMPfam hit to PF06481, COX Aromatic Rich Motif, score 2.2e-09 522373017278 HMMPfam hit to PF00116, Cytochrome C oxidase subunit II, periplasmic, score 0.00094 522373017279 3 probable transmembrane helices predicted for Smlt4401 by TMHMM2.0 at aa 9-28, 43-65 and 86-106 522373017280 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 522373017281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373017282 DNA-binding site [nucleotide binding]; DNA binding site 522373017283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373017284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373017285 homodimer interface [polypeptide binding]; other site 522373017286 catalytic residue [active] 522373017287 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fam, score 2.5e-18 522373017288 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.4e-06 522373017289 1 probable transmembrane helix predicted for Smlt4403 by TMHMM2.0 at aa 15-37 522373017290 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 522373017291 1 probable transmembrane helix predicted for Smlt4404 by TMHMM2.0 at aa 12-34 522373017292 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 522373017293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 522373017294 DNA-binding site [nucleotide binding]; DNA binding site 522373017295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 522373017296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373017297 homodimer interface [polypeptide binding]; other site 522373017298 catalytic residue [active] 522373017299 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fam, score 1.2e-12 522373017300 HMMPfam hit to PF00155, Aminotransferase class I and II, score 4.6e-06 522373017301 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 522373017302 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 522373017303 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373017304 catalytic residue [active] 522373017305 HMMPfam hit to PF00266, Aminotransferase class-V, score 1.5e-14 522373017306 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 522373017307 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 522373017308 N-terminal plug; other site 522373017309 ligand-binding site [chemical binding]; other site 522373017310 HMMPfam hit to PF00593, TonB dependent receptor, score 5.3e-25 522373017311 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.5e-21 522373017312 3 probable transmembrane helices predicted for Smlt4411 by TMHMM2.0 at aa 26-45, 57-79 and 115-134 522373017313 Helix-turn-helix domain; Region: HTH_18; pfam12833 522373017314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 522373017315 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 7.1e-11 522373017316 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 7.5e-27 522373017317 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373017318 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 522373017319 active site 522373017320 Repair protein; Region: Repair_PSII; pfam04536 522373017321 6 probable transmembrane helices predicted for Smlt4415 by TMHMM2.0 at aa 221-243, 247-269, 276-298, 302-324, 337-359 and 369-391 522373017322 HMMPfam hit to PF04536, Domain of unknown function (DUF477), score 2e-45 522373017323 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 522373017324 Zn binding site [ion binding]; other site 522373017325 HMMPfam hit to PF01432, Peptidase family M3, score 1.4e-08 522373017326 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 522373017327 HMMPfam hit to PF06520, Protein of unknown function (DUF1105), score 0.0019 522373017328 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 522373017329 10 probable transmembrane helices predicted for Smlt4420 by TMHMM2.0 at aa 30-52, 64-86, 106-128, 148-170, 196-218, 252-271, 281-303, 315-337, 357-379 and 448-470 522373017330 HMMPfam hit to PF02667, Short chain fatty acid transporter score 1.2e-63 522373017331 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 522373017332 UbiA prenyltransferase family; Region: UbiA; pfam01040 522373017333 8 probable transmembrane helices predicted for Smlt4422 by TMHMM2.0 at aa 43-65, 97-119, 123-142, 151-170, 175-197, 210-232, 242-264 and 277-296 522373017334 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 7.5e-65 522373017335 4 probable transmembrane helices predicted for Smlt4424 by TMHMM2.0 at aa 27-49, 59-81, 93-115 and 130-152 522373017336 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 522373017337 2 probable transmembrane helices predicted for Smlt4429 by TMHMM2.0 at aa 43-65 and 115-137 522373017338 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 522373017339 RHS Repeat; Region: RHS_repeat; pfam05593 522373017340 RHS Repeat; Region: RHS_repeat; pfam05593 522373017341 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 522373017342 RHS Repeat; Region: RHS_repeat; pfam05593 522373017343 RHS Repeat; Region: RHS_repeat; pfam05593 522373017344 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 522373017345 HMMPfam hit to PF05593, RHS Repeat, score 2.6 522373017346 HMMPfam hit to PF05593, RHS Repeat, score 0.005 522373017347 HMMPfam hit to PF05593, RHS Repeat, score 0.0076 522373017348 HMMPfam hit to PF05593, RHS Repeat, score 0.00011 522373017349 HMMPfam hit to PF05593, RHS Repeat, score 0.016 522373017350 HMMPfam hit to PF05593, RHS Repeat, score 0.00021 522373017351 HMMPfam hit to PF05593, RHS Repeat, score 0.0048 522373017352 HMMPfam hit to PF05593, RHS Repeat, score 1.8e-07 522373017353 HMMPfam hit to PF05593, RHS Repeat, score 1.5e-07 522373017354 HMMPfam hit to PF05593, RHS Repeat, score 0.012 522373017355 HMMPfam hit to PF05593, RHS Repeat, score 1.1 522373017356 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 522373017357 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 522373017358 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Rossm, score 7.5e-05 522373017359 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373017360 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 522373017361 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373017362 HMMPfam hit to PF00593, TonB dependent receptor, score 6.3e-32 522373017363 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.9e-20 522373017364 1 probable transmembrane helix predicted for Smlt4432 by TMHMM2.0 at aa 39-61 522373017365 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 522373017366 CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596 522373017367 putative active site [active] 522373017368 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 522373017369 putative catalytic site [active] 522373017370 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 522373017371 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 522373017372 HMMPfam hit to PF08305, NPCBM domain, score 1.5e-06 522373017373 HMMPfam hit to PF00754, F5/8 type C domain, score 5e-06 522373017374 HMMPfam hit to PF01055, Glycosyl hydrolases family, score 1.4e-54 522373017375 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 522373017376 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 522373017377 dimer interface [polypeptide binding]; other site 522373017378 active site 522373017379 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 522373017380 putative active site [active] 522373017381 HMMPfam hit to PF01380, SIS domain, score 0.01 522373017382 HMMPfam hit to PF01380, SIS domain, score 0.021 522373017383 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 522373017384 HMMPfam hit to PF00480, ROK family, score 5.4e-24 522373017385 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 522373017386 HMMPfam hit to PF08013, Tagatose 6 phosphate kinase, score 4.3e-247 522373017387 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 522373017388 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 522373017389 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 522373017390 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 0.0032 522373017391 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 2.1e-19 522373017392 HMMPfam hit to PF08279, HTH domain, score 0.0032 522373017393 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 6.4e-58 522373017394 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 522373017395 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 522373017396 active site 522373017397 HMMPfam hit to PF01979, Amidohydrolase family, score 2e-06 522373017398 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 522373017399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373017400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373017401 HMMPfam hit to PF00083, Sugar (and other) transporter score 4.9e-75 522373017402 12 probable transmembrane helices predicted for Smlt4439 by TMHMM2.0 at aa 46-68, 83-105, 118-140, 145-167, 174-196, 229-248, 305-327, 347-366, 373-395, 523-545, 558-580 and 585-607 522373017403 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.4e-19 522373017404 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 522373017405 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 522373017406 6 probable transmembrane helices predicted for Smlt4441 by TMHMM2.0 at aa 20-42, 47-69, 76-93, 98-120, 132-154 and 159-181 522373017407 HMMPfam hit to PF05594, no description, score 4.4 522373017408 putative chorionicgonadotrophin hormone-like protein, pseudogene;N-terminus to codon 82 is similar to codons 38 to 118 of S.maltophilia xcg chorionicgonadotropic hormone-like protein (cg-like protein). UniProt:P37126 (443 aa) fasta scores: E()=4.9e-28, 97.531% id in 81 aa; similarity:fasta; with=UniProt:P37126; maltophilia).; xcg; Chorionicgonadotropic hormone-like protein (CG-like protein).; length=443; id 97.531%; ungapped id 97.531%; E()=4.9e-28; 81 aa overlap; query 1-81; subject 37-117 522373017409 putative adhesin, pseudogene;Similar to Neisseria meningitidis serogroup B mafb-related protein. UniProt:Q9K0F4 (422 aa) fasta scores: E()=1.9e-10, 53.125% id in 64 aa; similarity:fasta; with=UniProt:Q9K0F4; Neisseria meningitidis serogroup B.; MafB-related protein.; length=422; id 53.125%; ungapped id 53.125%; E()=1.9e-10; 64 aa overlap; query 2-65; subject 349-412 522373017410 haemagglutination activity domain; Region: Haemagg_act; pfam05860 522373017411 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 522373017412 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 522373017413 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 522373017414 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.3 522373017415 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.05 522373017416 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.7 522373017417 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.011 522373017418 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2 522373017419 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.072 522373017420 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.25 522373017421 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.0013 522373017422 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.89 522373017423 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.19 522373017424 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.0063 522373017425 HMMPfam hit to PF05594, Haemagluttinin repeat, score 6.9e-08 522373017426 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.00013 522373017427 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.00042 522373017428 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.078 522373017429 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.047 522373017430 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.7 522373017431 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.07 522373017432 HMMPfam hit to PF05594, Haemagluttinin repeat, score 5.8e-06 522373017433 HMMPfam hit to PF05860, haemagglutination activity domain, score 6.9e-42 522373017434 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 522373017435 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 522373017436 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 522373017437 HMMPfam hit to PF03865, Haemolysin secretion/activation protein ShlB, score 3.8e-10 522373017438 HMMPfam hit to PF08479, POTRA domain, ShlB-type, score 1e-22 522373017439 comF family protein; Region: comF; TIGR00201 522373017440 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 522373017441 active site 522373017442 Major royal jelly protein; Region: MRJP; pfam03022 522373017443 HMMPfam hit to PF03022, Major royal jelly protein, score 1.8e-20 522373017444 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 522373017445 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 522373017446 putative ion selectivity filter; other site 522373017447 putative pore gating glutamate residue; other site 522373017448 putative H+/Cl- coupling transport residue; other site 522373017449 10 probable transmembrane helices predicted for Smlt4458 by TMHMM2.0 at aa 25-44, 59-81, 136-153, 163-185, 197-219, 234-256, 276-298, 332-354, 366-388 and 398-420 522373017450 HMMPfam hit to PF00654, Voltage gated chloride channel, score 2e-33 522373017451 biotin synthase; Provisional; Region: PRK15108 522373017452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 522373017453 FeS/SAM binding site; other site 522373017454 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 522373017455 HMMPfam hit to PF04055, Radical SAM superfamily, score 5.7e-25 522373017456 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 7.1e-49 522373017457 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 522373017458 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 522373017459 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 522373017460 catalytic residue [active] 522373017461 HMMPfam hit to PF00202, Aminotransferase class-III, score 0.0046 522373017462 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.3e-50 522373017463 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 522373017464 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 8.3e-18 522373017465 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 522373017466 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 522373017467 putative NAD(P) binding site [chemical binding]; other site 522373017468 putative active site [active] 522373017469 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.7e-17 522373017470 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 522373017471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373017472 S-adenosylmethionine binding site [chemical binding]; other site 522373017473 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 9.1e-05 522373017474 HMMPfam hit to PF08241, Methyltransferase domain, score 3.5e-34 522373017475 HMMPfam hit to PF08242, Methyltransferase domain, score 1.9e-18 522373017476 Uncharacterized conserved protein [Function unknown]; Region: COG1434 522373017477 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 522373017478 putative active site [active] 522373017479 HMMPfam hit to PF02698, DUF218 domain, score 9.4e-56 522373017480 1 probable transmembrane helix predicted for Smlt4469 by TMHMM2.0 at aa 15-37 522373017481 serine racemase; Region: PLN02970 522373017482 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 522373017483 tetramer interface [polypeptide binding]; other site 522373017484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 522373017485 catalytic residue [active] 522373017486 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 2.2e-61 522373017487 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 522373017488 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 522373017489 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 522373017490 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 8.9e-267 522373017491 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00044 522373017492 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 522373017493 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.2e-51 522373017494 HMMPfam hit to PF02321, Outer membrane efflux protein, score 5.3e-40 522373017495 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 522373017496 Protein export membrane protein; Region: SecD_SecF; cl14618 522373017497 Protein export membrane protein; Region: SecD_SecF; cl14618 522373017498 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 522373017499 13 probable transmembrane helices predicted for Smlt4475 by TMHMM2.0 at aa 10-32, 316-335, 340-359, 366-388, 392-414, 438-460, 475-497, 548-570, 875-894, 896-918, 928-950, 971-993 and 1008-1030 522373017500 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 522373017501 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373017502 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373017503 HMMPfam hit to PF00529, HlyD family secretion protein, score 6.2e-60 522373017504 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 522373017505 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 522373017506 dimerization interface [polypeptide binding]; other site 522373017507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373017508 dimer interface [polypeptide binding]; other site 522373017509 phosphorylation site [posttranslational modification] 522373017510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373017511 ATP binding site [chemical binding]; other site 522373017512 Mg2+ binding site [ion binding]; other site 522373017513 G-X-G motif; other site 522373017514 2 probable transmembrane helices predicted for Smlt4477 by TMHMM2.0 at aa 93-115 and 243-265 522373017515 HMMPfam hit to PF00672, HAMP domain, score 5.7e-20 522373017516 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.4e-15 522373017517 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.9e-42 522373017518 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 522373017519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373017520 active site 522373017521 phosphorylation site [posttranslational modification] 522373017522 intermolecular recognition site; other site 522373017523 dimerization interface [polypeptide binding]; other site 522373017524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 522373017525 DNA binding site [nucleotide binding] 522373017526 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.9e-33 522373017527 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 3.1e-17 522373017528 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 522373017529 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 522373017530 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 522373017531 trimer interface [polypeptide binding]; other site 522373017532 putative metal binding site [ion binding]; other site 522373017533 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 53 522373017534 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.11 522373017535 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 12 522373017536 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.2 522373017537 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4.6 522373017538 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.4 522373017539 RDD family; Region: RDD; pfam06271 522373017540 HMMPfam hit to PF06271, RDD family, score 5.9e-33 522373017541 2 probable transmembrane helices predicted for Smlt4481 by TMHMM2.0 at aa 32-54 and 61-83 522373017542 Integral membrane protein DUF95; Region: DUF95; pfam01944 522373017543 5 probable transmembrane helices predicted for Smlt4482 by TMHMM2.0 at aa 112-134, 191-213, 228-250, 271-293 and 298-320 522373017544 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 522373017545 5 probable transmembrane helices predicted for Smlt4483 by TMHMM2.0 at aa 40-62, 149-183, 215-237, 258-280 and 396-418 522373017546 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 522373017547 1 probable transmembrane helix predicted for Smlt4484 by TMHMM2.0 at aa 7-29 522373017548 MoxR-like ATPases [General function prediction only]; Region: COG0714 522373017549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 522373017550 Walker A motif; other site 522373017551 ATP binding site [chemical binding]; other site 522373017552 Walker B motif; other site 522373017553 arginine finger; other site 522373017554 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 2.4e-08 522373017555 HMMPfam hit to PF07726, ATPase family associated with various cellul, score 7e-83 522373017556 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 522373017557 Protein of unknown function DUF58; Region: DUF58; pfam01882 522373017558 1 probable transmembrane helix predicted for Smlt4486 by TMHMM2.0 at aa 7-29 522373017559 HMMPfam hit to PF01882, Protein of unknown function DUF58, score 2.7e-30 522373017560 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 522373017561 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 4.9e-189 522373017562 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 522373017563 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 522373017564 HMMPfam hit to PF00920, Dehydratase family, score 0 522373017565 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 522373017566 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 522373017567 3 probable transmembrane helices predicted for Smlt4494 by TMHMM2.0 at aa 10-32, 44-66 and 81-103 522373017568 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 522373017569 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 522373017570 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 522373017571 shikimate binding site; other site 522373017572 NAD(P) binding site [chemical binding]; other site 522373017573 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 5.4e-17 522373017574 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate bind, score 6.5e-31 522373017575 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 522373017576 Short C-terminal domain; Region: SHOCT; pfam09851 522373017577 1 probable transmembrane helix predicted for Smlt4496 by TMHMM2.0 at aa 10-32 522373017578 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 522373017579 dimer interface [polypeptide binding]; other site 522373017580 allosteric magnesium binding site [ion binding]; other site 522373017581 active site 522373017582 aspartate-rich active site metal binding site; other site 522373017583 Schiff base residues; other site 522373017584 HMMPfam hit to PF00490, Delta-aminolevulinic acid dehydratase, score 3.2e-199 522373017585 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 522373017586 HMMPfam hit to PF05249, Uncharacterised protein family (UPF0187), score 1.1e-100 522373017587 3 probable transmembrane helices predicted for Smlt4498 by TMHMM2.0 at aa 20-42, 52-71 and 219-241 522373017588 3 probable transmembrane helices predicted for Smlt4499 by TMHMM2.0 at aa 21-43, 48-70 and 77-99 522373017589 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 522373017590 HMMPfam hit to PF05960, Bacterial protein of unknown function (DUF88, score 3.5e-14 522373017591 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 522373017592 1 probable transmembrane helix predicted for Smlt4502 by TMHMM2.0 at aa 24-46 522373017593 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 522373017594 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373017595 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 1.6e-60 522373017596 HMMPfam hit to PF00930, Dipeptidyl peptidase IV (DPP IV) N-termi, score 3.2e-141 522373017597 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 522373017598 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 522373017599 C-terminal domain interface [polypeptide binding]; other site 522373017600 GSH binding site (G-site) [chemical binding]; other site 522373017601 dimer interface [polypeptide binding]; other site 522373017602 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 522373017603 N-terminal domain interface [polypeptide binding]; other site 522373017604 putative dimer interface [polypeptide binding]; other site 522373017605 active site 522373017606 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 5.9e-10 522373017607 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 4.4e-12 522373017608 hypothetical protein; Provisional; Region: PRK05208 522373017609 HMMPfam hit to PF03350, Uncharacterized protein family, UPF0114, score 7.1e-61 522373017610 3 probable transmembrane helices predicted for Smlt4505 by TMHMM2.0 at aa 13-30, 50-72 and 158-177 522373017611 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 522373017612 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 522373017613 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 2.1e-11 522373017614 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 522373017615 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 522373017616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 522373017617 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.0009 522373017618 Transposase IS200 like; Region: Y1_Tnp; pfam01797 522373017619 HMMPfam hit to PF07605, Protein of unknown function (DUF1568), score 1.4e-12 522373017620 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 522373017621 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 522373017622 6 probable transmembrane helices predicted for Smlt4510 by TMHMM2.0 at aa 25-44, 184-206, 237-259, 280-302, 312-331 and 360-382 522373017623 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 522373017624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 522373017625 Walker A/P-loop; other site 522373017626 ATP binding site [chemical binding]; other site 522373017627 Q-loop/lid; other site 522373017628 ABC transporter signature motif; other site 522373017629 Walker B; other site 522373017630 D-loop; other site 522373017631 H-loop/switch region; other site 522373017632 HMMPfam hit to PF00005, ABC transporter score 5.3e-56 522373017633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373017634 TAP-like protein; Region: Abhydrolase_4; pfam08386 522373017635 HMMPfam hit to PF08386, TAP-like protein, score 1e-24 522373017636 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.6e-14 522373017637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373017638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373017639 I-site; other site 522373017640 active site 522373017641 metal binding site [ion binding]; metal-binding site 522373017642 HMMPfam hit to PF00990, GGDEF domain, score 3.3e-07 522373017643 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 522373017644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 522373017645 Chitin binding domain; Region: Chitin_bind_3; pfam03067 522373017646 1 probable transmembrane helix predicted for Smlt4515 by TMHMM2.0 at aa 78-100 522373017647 HMMPfam hit to PF03067, Chitin binding domain, score 7.5e-73 522373017648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 522373017649 Chitin binding domain; Region: Chitin_bind_3; pfam03067 522373017650 1 probable transmembrane helix predicted for Smlt4516 by TMHMM2.0 at aa 101-123 522373017651 HMMPfam hit to PF03067, Chitin binding domain, score 1.9e-71 522373017652 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 522373017653 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 522373017654 FAD binding pocket [chemical binding]; other site 522373017655 FAD binding motif [chemical binding]; other site 522373017656 phosphate binding motif [ion binding]; other site 522373017657 beta-alpha-beta structure motif; other site 522373017658 NAD binding pocket [chemical binding]; other site 522373017659 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 4.6e-23 522373017660 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 1.8e-07 522373017661 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 522373017662 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 522373017663 Walker A/P-loop; other site 522373017664 ATP binding site [chemical binding]; other site 522373017665 Q-loop/lid; other site 522373017666 ABC transporter signature motif; other site 522373017667 Walker B; other site 522373017668 D-loop; other site 522373017669 H-loop/switch region; other site 522373017670 HMMPfam hit to PF00005, ABC transporter score 8.3e-54 522373017671 inner membrane transport permease; Provisional; Region: PRK15066 522373017672 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 522373017673 HMMPfam hit to PF01061, ABC-2 type transporter score 2.5e-42 522373017674 6 probable transmembrane helices predicted for Smlt4519 by TMHMM2.0 at aa 31-53, 68-90, 111-133, 148-170, 177-196 and 233-255 522373017675 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 522373017676 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 522373017677 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 522373017678 HMMPfam hit to PF02558, Ketopantoate reductase PanE/ApbA, score 7.8e-55 522373017679 HMMPfam hit to PF08546, Ketopantoate reductase PanE/ApbA C terminal, score 7.1e-30 522373017680 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 522373017681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373017682 NAD(P) binding site [chemical binding]; other site 522373017683 active site 522373017684 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 2.8e-05 522373017685 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 522373017686 active site 522373017687 HMMPfam hit to PF01026, TatD related DNase, score 2e-101 522373017688 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 522373017689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 522373017690 ATP binding site [chemical binding]; other site 522373017691 putative Mg++ binding site [ion binding]; other site 522373017692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 522373017693 nucleotide binding region [chemical binding]; other site 522373017694 Helicase associated domain (HA2); Region: HA2; pfam04408 522373017695 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 522373017696 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 5.6e-18 522373017697 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 1.3e-14 522373017698 HMMPfam hit to PF08482, ATP-dependent helicase C-terminal, score 4.6e-83 522373017699 1 probable transmembrane helix predicted for Smlt4525 by TMHMM2.0 at aa 96-115 522373017700 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 522373017701 pseudouridine synthase; Region: TIGR00093 522373017702 active site 522373017703 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 5.2e-26 522373017704 2 probable transmembrane helices predicted for Smlt4527 by TMHMM2.0 at aa 22-44 and 65-82 522373017705 Predicted methyltransferase [General function prediction only]; Region: COG4798 522373017706 Methyltransferase domain; Region: Methyltransf_23; pfam13489 522373017707 S-adenosylmethionine binding site [chemical binding]; other site 522373017708 1 probable transmembrane helix predicted for Smlt4528 by TMHMM2.0 at aa 32-54 522373017709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 522373017710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 522373017711 active site 522373017712 catalytic tetrad [active] 522373017713 HMMPfam hit to PF00248, Aldo/keto reductase family, score 1.9e-61 522373017714 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 522373017715 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 522373017716 HMMPfam hit to PF01145, SPFH domain / Band, score 3.9e-19 522373017717 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 522373017718 hypothetical protein; Reviewed; Region: PRK09588 522373017719 HMMPfam hit to PF01139, Uncharacterized protein family UPF0027, score 4.4e-188 522373017720 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 522373017721 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373017722 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0012 522373017723 HMMPfam hit to PF03486, HI0933-like protein, score 0.0042 522373017724 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 6.8e-06 522373017725 1 probable transmembrane helix predicted for Smlt4534 by TMHMM2.0 at aa 15-32 522373017726 Predicted transcriptional regulator [Transcription]; Region: COG1959 522373017727 Transcriptional regulator; Region: Rrf2; pfam02082 522373017728 HMMPfam hit to PF02082, Transcriptional regulator, score 3e-21 522373017729 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 522373017730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 522373017731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373017732 dimer interface [polypeptide binding]; other site 522373017733 putative CheW interface [polypeptide binding]; other site 522373017734 2 probable transmembrane helices predicted for Smlt4536 by TMHMM2.0 at aa 15-37 and 186-208 522373017735 HMMPfam hit to PF00672, HAMP domain, score 1.4e-15 522373017736 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1e-99 522373017737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373017738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373017739 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 522373017740 dimerization interface [polypeptide binding]; other site 522373017741 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.8e-46 522373017742 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.3e-21 522373017743 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 522373017744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373017745 putative substrate translocation pore; other site 522373017746 12 probable transmembrane helices predicted for Smlt4538 by TMHMM2.0 at aa 23-45, 60-82, 89-108, 118-140, 147-169, 179-201, 221-243, 253-275, 287-309, 313-335, 348-370 and 375-397 522373017747 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.4e-57 522373017748 HMMPfam hit to PF00248, Aldo/keto reductase family, score 2.2e-100 522373017749 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 522373017750 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 522373017751 active site 522373017752 catalytic tetrad [active] 522373017753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373017754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373017755 dimer interface [polypeptide binding]; other site 522373017756 phosphorylation site [posttranslational modification] 522373017757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373017758 ATP binding site [chemical binding]; other site 522373017759 Mg2+ binding site [ion binding]; other site 522373017760 G-X-G motif; other site 522373017761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373017762 Response regulator receiver domain; Region: Response_reg; pfam00072 522373017763 active site 522373017764 phosphorylation site [posttranslational modification] 522373017765 intermolecular recognition site; other site 522373017766 dimerization interface [polypeptide binding]; other site 522373017767 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.7e-15 522373017768 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 7.8e-27 522373017769 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.1e-17 522373017770 4 probable transmembrane helices predicted for Smlt4540 by TMHMM2.0 at aa 71-93, 105-127, 147-169 and 174-196 522373017771 1 probable transmembrane helix predicted for Smlt4542 by TMHMM2.0 at aa 24-46 522373017772 Uncharacterized conserved protein [Function unknown]; Region: COG1434 522373017773 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 522373017774 putative active site [active] 522373017775 HMMPfam hit to PF02698, DUF218 domain, score 9.8e-41 522373017776 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 522373017777 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.2e-10 522373017778 putative colicin secretion/processing ATP-binding protein, pseudogene;Similar to C-terminus of bpseudomallei colicin v processing peptidase BPSL3093 (753 aa) fasta scores: E()=9.4e-29, id=58.4% id in 149 aa, and to Escherichia coli mchf probable microcin h47 secretion/processing atp-binding protein mchf (ec 3.4.22.-). UniProt:Q9EXN5 (698 aa) fasta scores: E()=1.4e-11, 53.782% id in 119 aa, and to C-terminus of Xanthomonas oryzae pv. oryzae (strain maff 311018). colicin v secretion abc transporter atp-binding protein. UniProt:Q2P4U1 (EMBL:AP008229 (704 aa) fasta scores: E()=4.8e-22, 77.612% id in 134 aa; similarity:fasta; BPSL3093; bpseudomallei; colicin V processing peptidase; length 753 aa; id=58.4%; E()=9.4e-29; 149 aa overlap; query 1-149 aa; subject 574-721 aa; similarity:fasta; with=UniProt:Q9EXN5; Escherichia coli.; mchF; Probable microcin H47 secretion/processing ATP-binding protein mchF (EC 3.4.22.-).; length=698; id 53.782%; ungapped id 53.782%; E()=1.4e-11; 119 aa overlap; query 1-119; subject 578-696; similarity:fasta; with=UniProt:Q2P4U1 (EMBL:AP008229;); Xanthomonas oryzae pv. oryzae (strain MAFF 311018).; Colicin V secretion ABC transporter ATP-binding protein.; length=704; id 77.612%; ungapped id 77.612%; E()=4.8e-22; 134 aa overlap; query 1-134; subject 557-690 522373017779 HMMPfam hit to PF00005, ABC transporter score 1.7e-10 522373017780 4 probable transmembrane helices predicted for Smlt4546 by TMHMM2.0 at aa 19-41, 51-69, 74-91 and 95-117 522373017781 putative transposase, pseudogene;Similar to codons 30 to 68 of Xanthomonas oryzae pv. oryzae putative transposase. putative transposase. UniProt:Q5GXG6 (161 aa) fasta scores: E()=4.3e-10, 78.947% id in 38 aa; similarity:fasta; with=UniProt:Q5GXG6; Xanthomonas oryzae pv. oryzae.; Putative transposase. Putative transposase.; length=161; id 78.947%; ungapped id 78.947%; E()=4.3e-10; 38 aa overlap; query 1-38; subject 30-67 522373017782 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 522373017783 CoA binding domain; Region: CoA_binding_2; pfam13380 522373017784 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 522373017785 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 522373017786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 522373017787 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 522373017788 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.6e-10 522373017789 HMMPfam hit to PF02629, CoA binding domain, score 7.8e-09 522373017790 MgtE intracellular N domain; Region: MgtE_N; smart00924 522373017791 FOG: CBS domain [General function prediction only]; Region: COG0517 522373017792 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 522373017793 Divalent cation transporter; Region: MgtE; pfam01769 522373017794 3 probable transmembrane helices predicted for Smlt4551 by TMHMM2.0 at aa 458-480, 492-514 and 534-556 522373017795 HMMPfam hit to PF01769, Divalent cation transporter score 7.1e-38 522373017796 HMMPfam hit to PF00571, CBS domain pair, score 2.7e-16 522373017797 HMMPfam hit to PF03448, MgtE intracellular domain, score 3e-25 522373017798 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 522373017799 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 522373017800 TrkA-N domain; Region: TrkA_N; pfam02254 522373017801 11 probable transmembrane helices predicted for Smlt4552 by TMHMM2.0 at aa 4-23, 28-50, 55-72, 85-107, 112-134, 147-169, 184-201, 264-281, 291-310, 323-342 and 357-379 522373017802 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 7.6e-67 522373017803 HMMPfam hit to PF02254, TrkA-N domain, score 1.9e-30 522373017804 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373017805 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373017806 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373017807 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373017808 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373017809 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373017810 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373017811 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373017812 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373017813 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 522373017814 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373017815 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 522373017816 HMMPfam hit to PF00023, Ankyrin repeat, score 2.4e-07 522373017817 HMMPfam hit to PF00023, Ankyrin repeat, score 1.4 522373017818 HMMPfam hit to PF00023, Ankyrin repeat, score 6.8e-06 522373017819 HMMPfam hit to PF00023, Ankyrin repeat, score 0.0037 522373017820 HMMPfam hit to PF00023, Ankyrin repeat, score 0.0011 522373017821 HMMPfam hit to PF00023, Ankyrin repeat, score 1.5 522373017822 HMMPfam hit to PF00023, Ankyrin repeat, score 1e-05 522373017823 HMMPfam hit to PF00023, Ankyrin repeat, score 0.22 522373017824 HMMPfam hit to PF00023, Ankyrin repeat, score 18 522373017825 HMMPfam hit to PF00023, Ankyrin repeat, score 10 522373017826 HMMPfam hit to PF00023, Ankyrin repeat, score 5.7 522373017827 HMMPfam hit to PF00023, Ankyrin repeat, score 0.072 522373017828 HMMPfam hit to PF00023, Ankyrin repeat, score 1.8e-06 522373017829 HMMPfam hit to PF00023, Ankyrin repeat, score 0.18 522373017830 HMMPfam hit to PF00023, Ankyrin repeat, score 6.4e-07 522373017831 HMMPfam hit to PF00023, Ankyrin repeat, score 0.21 522373017832 HMMPfam hit to PF00023, Ankyrin repeat, score 4.8 522373017833 5 probable transmembrane helices predicted for Smlt4553 by TMHMM2.0 at aa 12-34, 68-90, 97-119, 148-170 and 177-199 522373017834 YcgL domain; Region: YcgL; pfam05166 522373017835 HMMPfam hit to PF05166, Family of unknown function (DUF709), score 2.1e-19 522373017836 1 probable transmembrane helix predicted for Smlt4554 by TMHMM2.0 at aa 24-46 522373017837 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 522373017838 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 522373017839 dimer interface [polypeptide binding]; other site 522373017840 active site 522373017841 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 2.6e-54 522373017842 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 6.3e-34 522373017843 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 522373017844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373017845 NAD(P) binding site [chemical binding]; other site 522373017846 active site 522373017847 HMMPfam hit to PF00106, short chain dehydrogenase, score 3.3e-34 522373017848 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 522373017849 active site 2 [active] 522373017850 active site 1 [active] 522373017851 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 522373017852 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 522373017853 dimer interface [polypeptide binding]; other site 522373017854 active site 522373017855 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 1.3e-32 522373017856 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 7.4e-08 522373017857 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 522373017858 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 522373017859 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 522373017860 HMMPfam hit to PF04820, Tryptophan halogenase, score 2.3e-07 522373017861 HMMPfam hit to PF01494, FAD binding domain, score 2.7e-06 522373017862 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 3.8e-05 522373017863 Predicted exporter [General function prediction only]; Region: COG4258 522373017864 12 probable transmembrane helices predicted for Smlt4562 by TMHMM2.0 at aa 23-45, 275-292, 299-321, 326-348, 361-383, 393-415, 444-461, 654-671, 678-700, 704-726, 733-755 and 759-781 522373017865 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 522373017866 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 522373017867 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein L, score 0.00012 522373017868 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 522373017869 active site 522373017870 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.1e-08 522373017871 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 522373017872 active sites [active] 522373017873 tetramer interface [polypeptide binding]; other site 522373017874 HMMPfam hit to PF00221, Phenylalanine and histidine ammonia-lyase, score 5.1e-116 522373017875 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 522373017876 putative acyl-acceptor binding pocket; other site 522373017877 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 522373017878 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 522373017879 Ligand binding site; other site 522373017880 Putative Catalytic site; other site 522373017881 DXD motif; other site 522373017882 HMMPfam hit to PF00535, Glycosyl transferase family, score 4.1e-19 522373017883 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 522373017884 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 522373017885 AMP binding site [chemical binding]; other site 522373017886 active site 522373017887 acyl-activating enzyme (AAE) consensus motif; other site 522373017888 CoA binding site [chemical binding]; other site 522373017889 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 522373017890 active site 2 [active] 522373017891 active site 1 [active] 522373017892 HMMPfam hit to PF00501, AMP-binding enzyme, score 1e-07 522373017893 Predicted membrane protein [Function unknown]; Region: COG4648 522373017894 6 probable transmembrane helices predicted for Smlt4569 by TMHMM2.0 at aa 21-43, 47-64, 69-91, 95-114, 144-163 and 168-190 522373017895 acyl carrier protein; Provisional; Region: PRK05350 522373017896 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 6e-10 522373017897 Phosphopantetheine attachment site; Region: PP-binding; cl09936 522373017898 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 522373017899 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 522373017900 putative acyl-acceptor binding pocket; other site 522373017901 HMMPfam hit to PF01553, Acyltransferase, score 6.2e-17 522373017902 1 probable transmembrane helix predicted for Smlt4572 by TMHMM2.0 at aa 20-42 522373017903 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 522373017904 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 522373017905 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 522373017906 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 2.2e-127 522373017907 8 probable transmembrane helices predicted for Smlt4574 by TMHMM2.0 at aa 30-52, 107-129, 142-164, 187-209, 222-244, 259-276, 289-311 and 326-348 522373017908 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 522373017909 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 5.5e-175 522373017910 9 probable transmembrane helices predicted for Smlt4575 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 124-146, 182-204, 216-235, 321-343, 356-378 and 406-428 522373017911 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373017912 HMMPfam hit to PF02687, Predicted permease, score 1.5e-09 522373017913 4 probable transmembrane helices predicted for Smlt4576 by TMHMM2.0 at aa 31-53, 299-321, 342-364 and 379-401 522373017914 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 522373017915 HMMPfam hit to PF02687, Predicted permease, score 9.1e-16 522373017916 4 probable transmembrane helices predicted for Smlt4577 by TMHMM2.0 at aa 20-42, 304-326, 346-368 and 388-410 522373017917 1 probable transmembrane helix predicted for Smlt4578 by TMHMM2.0 at aa 48-70 522373017918 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 522373017919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 522373017920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 522373017921 DNA binding residues [nucleotide binding] 522373017922 HMMPfam hit to PF04545, Sigma-70, region, score 2.1e-10 522373017923 HMMPfam hit to PF08281, Sigma-70, region, score 5.1e-13 522373017924 HMMPfam hit to PF04542, Sigma-70 region, score 3.4e-12 522373017925 3 probable transmembrane helices predicted for Smlt4580 by TMHMM2.0 at aa 4-21, 53-75 and 79-101 522373017926 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 522373017927 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 522373017928 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 1.1e-40 522373017929 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 522373017930 nudix motif; other site 522373017931 HMMPfam hit to PF00293, NUDIX domain, score 4e-13 522373017932 4 probable transmembrane helices predicted for Smlt4583 by TMHMM2.0 at aa 31-53, 81-103, 108-130 and 157-179 522373017933 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 522373017934 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 522373017935 HMMPfam hit to PF01218, Coproporphyrinogen III oxidase, score 5.3e-180 522373017936 Predicted membrane protein [Function unknown]; Region: COG2323 522373017937 3 probable transmembrane helices predicted for Smlt4588 by TMHMM2.0 at aa 67-89, 96-115 and 125-147 522373017938 DNA polymerase I; Provisional; Region: PRK05755 522373017939 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 522373017940 active site 522373017941 metal binding site 1 [ion binding]; metal-binding site 522373017942 putative 5' ssDNA interaction site; other site 522373017943 metal binding site 3; metal-binding site 522373017944 metal binding site 2 [ion binding]; metal-binding site 522373017945 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 522373017946 putative DNA binding site [nucleotide binding]; other site 522373017947 putative metal binding site [ion binding]; other site 522373017948 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 522373017949 active site 522373017950 catalytic site [active] 522373017951 substrate binding site [chemical binding]; other site 522373017952 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 522373017953 active site 522373017954 DNA binding site [nucleotide binding] 522373017955 catalytic site [active] 522373017956 HMMPfam hit to PF00476, DNA polymerase family A, score 8.9e-193 522373017957 HMMPfam hit to PF01612, 3'-5' exonuclease, score 1.3e-47 522373017958 HMMPfam hit to PF01367, 5'-3' exonuclease, C-terminal SAM fold, score 5.5e-36 522373017959 HMMPfam hit to PF02739, 5'-3' exonuclease, N-terminal resolvase-, score 5.7e-69 522373017960 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 522373017961 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 522373017962 Ligand Binding Site [chemical binding]; other site 522373017963 HMMPfam hit to PF00582, Universal stress protein family, score 7.4e-22 522373017964 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 522373017965 active site 522373017966 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 522373017967 Part of AAA domain; Region: AAA_19; pfam13245 522373017968 Family description; Region: UvrD_C_2; pfam13538 522373017969 HMMPfam hit to PF00580, UvrD/REP helicase, score 8.6e-204 522373017970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 522373017971 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 522373017972 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 522373017973 1 probable transmembrane helix predicted for Smlt4596 by TMHMM2.0 at aa 13-35 522373017974 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 522373017975 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 522373017976 putative active site [active] 522373017977 catalytic site [active] 522373017978 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 522373017979 putative active site [active] 522373017980 catalytic site [active] 522373017981 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.002 522373017982 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 3.8e-07 522373017983 2 probable transmembrane helices predicted for Smlt4597 by TMHMM2.0 at aa 65-87 and 99-121 522373017984 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 522373017985 HMMPfam hit to PF00471, Ribosomal protein L33, score 3.7e-16 522373017986 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 522373017987 HMMPfam hit to PF00830, Ribosomal L28 family, score 5.4e-31 522373017988 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 522373017989 homodimer interface [polypeptide binding]; other site 522373017990 active site 522373017991 TDP-binding site; other site 522373017992 acceptor substrate-binding pocket; other site 522373017993 HMMPfam hit to PF03033, Glycosyltransferase family, score 0.001 522373017994 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 522373017995 active site 522373017996 catalytic site [active] 522373017997 substrate binding site [chemical binding]; other site 522373017998 HMMPfam hit to PF00929, Exonuclease, score 3.5e-36 522373017999 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373018000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373018001 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 522373018002 putative effector binding pocket; other site 522373018003 putative dimerization interface [polypeptide binding]; other site 522373018004 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.9e-37 522373018005 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.4e-15 522373018006 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 522373018007 homotrimer interaction site [polypeptide binding]; other site 522373018008 putative active site [active] 522373018009 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 2.6e-31 522373018010 1 probable transmembrane helix predicted for Smlt4605 by TMHMM2.0 at aa 7-29 522373018011 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 522373018012 1 probable transmembrane helix predicted for Smlt4606 by TMHMM2.0 at aa 12-34 522373018013 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.3e-09 522373018014 HMMPfam hit to PF02321, Outer membrane efflux protein, score 6.6e-21 522373018015 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 522373018016 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373018017 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.002 522373018018 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 522373018019 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 1.1e-301 522373018020 11 probable transmembrane helices predicted for Smlt4608 by TMHMM2.0 at aa 38-60, 398-432, 447-469, 499-516, 531-553, 596-615, 931-950, 957-976, 981-1003, 1029-1051 and 1061-1083 522373018021 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 522373018022 HMMPfam hit to PF05960, Bacterial protein of unknown function (DUF88, score 1.2e-211 522373018023 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 522373018024 HMMPfam hit to PF07578, Lipid A Biosynthesis N-terminal domain, score 1.1e-35 522373018025 2 probable transmembrane helices predicted for Smlt4610 by TMHMM2.0 at aa 15-37 and 58-77 522373018026 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 522373018027 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 522373018028 Ligand binding site; other site 522373018029 Putative Catalytic site; other site 522373018030 DXD motif; other site 522373018031 HMMPfam hit to PF00535, Glycosyl transferase family, score 1.5e-25 522373018032 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 522373018033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 522373018034 NAD(P) binding site [chemical binding]; other site 522373018035 active site 522373018036 HMMPfam hit to PF04321, RmlD substrate binding domain, score 2.9e-07 522373018037 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 0.00068 522373018038 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 6.3e-10 522373018039 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 1.5e-74 522373018040 HMMPfam hit to PF07993, Male sterility protein, score 2.9e-06 522373018041 HMMPfam hit to PF00106, short chain dehydrogenase, score 8.4e-06 522373018042 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 522373018043 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 522373018044 ParB-like nuclease domain; Region: ParBc; pfam02195 522373018045 KorB domain; Region: KorB; pfam08535 522373018046 HMMPfam hit to PF02195, ParB-like nuclease domain, score 1.2e-40 522373018047 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 522373018048 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 522373018049 P-loop; other site 522373018050 Magnesium ion binding site [ion binding]; other site 522373018051 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 522373018052 Magnesium ion binding site [ion binding]; other site 522373018053 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 8.8e-59 522373018054 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 522373018055 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 522373018056 HMMPfam hit to PF02527, Glucose inhibited division protein, score 6.3e-64 522373018057 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 522373018058 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 6.1e-14 522373018059 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 522373018060 putative catalytic site [active] 522373018061 putative phosphate binding site [ion binding]; other site 522373018062 active site 522373018063 metal binding site A [ion binding]; metal-binding site 522373018064 DNA binding site [nucleotide binding] 522373018065 putative AP binding site [nucleotide binding]; other site 522373018066 putative metal binding site B [ion binding]; other site 522373018067 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 2.8e-51 522373018068 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 522373018069 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 522373018070 NAD(P) binding site [chemical binding]; other site 522373018071 catalytic residues [active] 522373018072 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 5.1e-63 522373018073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 522373018074 putative substrate translocation pore; other site 522373018075 HMMPfam hit to PF00083, Sugar (and other) transporter score 1.1e-08 522373018076 12 probable transmembrane helices predicted for Smlt4621 by TMHMM2.0 at aa 62-84, 99-121, 133-152, 156-178, 199-221, 236-258, 288-310, 325-347, 356-378, 499-521, 534-556 and 566-584 522373018077 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.2e-17 522373018078 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 522373018079 acetyl-CoA synthetase; Provisional; Region: PRK00174 522373018080 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 522373018081 active site 522373018082 CoA binding site [chemical binding]; other site 522373018083 acyl-activating enzyme (AAE) consensus motif; other site 522373018084 AMP binding site [chemical binding]; other site 522373018085 acetate binding site [chemical binding]; other site 522373018086 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.1e-139 522373018087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 522373018088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373018089 active site 522373018090 phosphorylation site [posttranslational modification] 522373018091 intermolecular recognition site; other site 522373018092 dimerization interface [polypeptide binding]; other site 522373018093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 522373018094 DNA binding residues [nucleotide binding] 522373018095 dimerization interface [polypeptide binding]; other site 522373018096 HMMPfam hit to PF00072, Response regulator receiver domain, score 7.9e-24 522373018097 HMMPfam hit to PF08281, Sigma-70, region, score 0.0011 522373018098 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.5e-20 522373018099 Predicted membrane protein [Function unknown]; Region: COG1971 522373018100 Domain of unknown function DUF; Region: DUF204; pfam02659 522373018101 Domain of unknown function DUF; Region: DUF204; pfam02659 522373018102 6 probable transmembrane helices predicted for Smlt4626 by TMHMM2.0 at aa 4-23, 36-58, 68-87, 107-129, 134-156 and 169-188 522373018103 HMMPfam hit to PF02659, Domain of unknown function DUF, score 1.4e-18 522373018104 HMMPfam hit to PF02659, Domain of unknown function DUF, score 2.9e-17 522373018105 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 522373018106 Na binding site [ion binding]; other site 522373018107 PAS fold; Region: PAS_7; pfam12860 522373018108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 522373018109 putative active site [active] 522373018110 heme pocket [chemical binding]; other site 522373018111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 522373018112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 522373018113 dimer interface [polypeptide binding]; other site 522373018114 phosphorylation site [posttranslational modification] 522373018115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 522373018116 ATP binding site [chemical binding]; other site 522373018117 Mg2+ binding site [ion binding]; other site 522373018118 G-X-G motif; other site 522373018119 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 522373018120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 522373018121 active site 522373018122 phosphorylation site [posttranslational modification] 522373018123 intermolecular recognition site; other site 522373018124 dimerization interface [polypeptide binding]; other site 522373018125 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.7e-10 522373018126 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.9e-33 522373018127 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 5.9e-17 522373018128 12 probable transmembrane helices predicted for Smlt4627 by TMHMM2.0 at aa 5-24, 36-58, 68-87, 116-135, 155-177, 190-212, 227-249, 275-297, 322-344, 375-394, 404-426 and 438-460 522373018129 HMMPfam hit to PF00474, Sodium:solute symporter family, score 0.00023 522373018130 Peptidase S46; Region: Peptidase_S46; pfam10459 522373018131 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 522373018132 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 522373018133 Hsp70 protein; Region: HSP70; pfam00012 522373018134 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 522373018135 nucleotide binding site [chemical binding]; other site 522373018136 putative NEF/HSP70 interaction site [polypeptide binding]; other site 522373018137 SBD interface [polypeptide binding]; other site 522373018138 HMMPfam hit to PF00012, Hsp70 protein, score 2.4e-112 522373018139 5 probable transmembrane helices predicted for Smlt4630 by TMHMM2.0 at aa 346-368, 378-400, 417-439, 444-461 and 474-496 522373018140 HMMPfam hit to PF00226, DnaJ domain, score 0.003 522373018141 2 probable transmembrane helices predicted for Smlt4631 by TMHMM2.0 at aa 305-327 and 344-366 522373018142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 522373018143 Family of unknown function (DUF490); Region: DUF490; pfam04357 522373018144 HMMPfam hit to PF04357, Family of unknown function (DUF490), score 2.1e-122 522373018145 1 probable transmembrane helix predicted for Smlt4632 by TMHMM2.0 at aa 23-45 522373018146 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 522373018147 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 522373018148 Surface antigen; Region: Bac_surface_Ag; pfam01103 522373018149 HMMPfam hit to PF01103, Surface antigen, score 3.8e-72 522373018150 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 522373018151 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 522373018152 HMMPfam hit to PF05746, DALR anticodon binding domain, score 2.7e-05 522373018153 HMMPfam hit to PF02092, Glycyl-tRNA synthetase beta subunit, score 2.6e-197 522373018154 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 522373018155 dimer interface [polypeptide binding]; other site 522373018156 motif 1; other site 522373018157 active site 522373018158 motif 2; other site 522373018159 motif 3; other site 522373018160 HMMPfam hit to PF02091, Glycyl-tRNA synthetase alpha subunit, score 1.7e-225 522373018161 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 522373018162 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 522373018163 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 522373018164 Walker A motif; other site 522373018165 ATP binding site [chemical binding]; other site 522373018166 Walker B motif; other site 522373018167 HMMPfam hit to PF05157, GSPII_E N-terminal domain, score 1e-17 522373018168 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 1.7e-105 522373018169 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 522373018170 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 522373018171 catalytic triad [active] 522373018172 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.1e-06 522373018173 6 probable transmembrane helices predicted for Smlt4638 by TMHMM2.0 at aa 32-54, 59-81, 106-128, 175-197, 218-240 and 255-277 522373018174 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 522373018175 HMMPfam hit to PF00902, Sec-independent protein translocase, score 1.3e-91 522373018176 5 probable transmembrane helices predicted for Smlt4639 by TMHMM2.0 at aa 20-39, 76-98, 110-132, 161-183 and 196-218 522373018177 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 522373018178 HMMPfam hit to PF02416, mttA/Hcf106 family, score 3.5e-05 522373018179 1 probable transmembrane helix predicted for Smlt4640 by TMHMM2.0 at aa 4-21 522373018180 twin arginine translocase protein A; Provisional; Region: tatA; PRK04561 522373018181 HMMPfam hit to PF02416, mttA/Hcf106 family, score 3.5e-09 522373018182 1 probable transmembrane helix predicted for Smlt4641 by TMHMM2.0 at aa 10-32 522373018183 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 522373018184 putative amphipathic alpha helix; other site 522373018185 HMMPfam hit to PF04366, Family of unknown function (DUF500), score 6.2e-61 522373018186 ferrochelatase; Reviewed; Region: hemH; PRK00035 522373018187 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 522373018188 C-terminal domain interface [polypeptide binding]; other site 522373018189 active site 522373018190 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 522373018191 active site 522373018192 N-terminal domain interface [polypeptide binding]; other site 522373018193 HMMPfam hit to PF00762, Ferrochelatase, score 2.5e-105 522373018194 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 522373018195 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.5e-08 522373018196 PAS fold; Region: PAS; pfam00989 522373018197 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 522373018198 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 522373018199 dimer interface [polypeptide binding]; other site 522373018200 putative CheW interface [polypeptide binding]; other site 522373018201 4 probable transmembrane helices predicted for Smlt4645 by TMHMM2.0 at aa 27-44, 51-73, 88-110 and 117-139 522373018202 HMMPfam hit to PF00989, PAS fold, score 5.1e-06 522373018203 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 7.7e-93 522373018204 Benzoate membrane transport protein; Region: BenE; pfam03594 522373018205 benzoate transporter; Region: benE; TIGR00843 522373018206 HMMPfam hit to PF03594, Benzoate membrane transport protein, score 5.8e-193 522373018207 11 probable transmembrane helices predicted for Smlt4647 by TMHMM2.0 at aa 36-58, 73-92, 99-121, 125-147, 168-190, 195-217, 238-260, 275-297, 318-340, 350-372 and 379-401 522373018208 HMMPfam hit to PF00860, Permease family, score 0.011 522373018209 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 522373018210 3 probable transmembrane helices predicted for Smlt4648 by TMHMM2.0 at aa 157-175, 180-202 and 234-256 522373018211 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 522373018212 active site 522373018213 phosphate binding residues; other site 522373018214 catalytic residues [active] 522373018215 HMMPfam hit to PF01263, Aldose 1-epimerase, score 2.1e-36 522373018216 Transglycosylase SLT domain; Region: SLT_2; pfam13406 522373018217 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 522373018218 N-acetyl-D-glucosamine binding site [chemical binding]; other site 522373018219 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 522373018220 HMMPfam hit to PF01471, Putative peptidoglycan binding domain, score 5.5e-11 522373018221 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 522373018222 Methyltransferase domain; Region: Methyltransf_25; pfam13649 522373018223 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 522373018224 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 522373018225 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 522373018226 HMMPfam hit to PF03781, Domain of unknown function (DUF323), score 2.6e-26 522373018227 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 522373018228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 522373018229 metal binding site [ion binding]; metal-binding site 522373018230 active site 522373018231 I-site; other site 522373018232 7 probable transmembrane helices predicted for Smlt4653 by TMHMM2.0 at aa 20-42, 49-66, 81-103, 110-129, 149-171, 178-195 and 199-221 522373018233 HMMPfam hit to PF00990, GGDEF domain, score 1.7e-36 522373018234 hypothetical protein; Provisional; Region: PRK04233 522373018235 HMMPfam hit to PF02810, SEC-C motif, score 0.00015 522373018236 hypothetical protein; Provisional; Region: PRK10621 522373018237 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 522373018238 7 probable transmembrane helices predicted for Smlt4655 by TMHMM2.0 at aa 38-60, 75-94, 106-128, 132-149, 169-203, 233-255 and 262-281 522373018239 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 1.9e-29 522373018240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 522373018241 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 522373018242 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 522373018243 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 522373018244 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 522373018245 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 522373018246 GTP cyclohydrolase I; Provisional; Region: PLN03044 522373018247 active site 522373018248 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 3e-40 522373018249 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 522373018250 MarR family; Region: MarR_2; pfam12802 522373018251 HMMPfam hit to PF01047, MarR family, score 4.3e-09 522373018252 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 522373018253 HMMPfam hit to PF07869, Protein of unknown function (DUF1656), score 3.6e-24 522373018254 2 probable transmembrane helices predicted for Smlt4661 by TMHMM2.0 at aa 34-56 and 69-91 522373018255 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 522373018256 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 522373018257 HlyD family secretion protein; Region: HlyD_3; pfam13437 522373018258 1 probable transmembrane helix predicted for Smlt4662 by TMHMM2.0 at aa 12-34 522373018259 HMMPfam hit to PF00529, HlyD family secretion protein, score 8e-13 522373018260 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 522373018261 HMMPfam hit to PF02321, Outer membrane efflux protein, score 4.6e-11 522373018262 HMMPfam hit to PF02321, Outer membrane efflux protein, score 5.2e-28 522373018263 Fusaric acid resistance protein family; Region: FUSC; pfam04632 522373018264 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 522373018265 10 probable transmembrane helices predicted for Smlt4664 by TMHMM2.0 at aa 10-32, 57-79, 83-102, 109-128, 143-162, 357-379, 406-428, 435-454, 459-478 and 485-507 522373018266 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved re, score 1e-20 522373018267 conserved hypothetical protein, pseudogene;Similar to N-terminus of Flavobacteria bacterium bbfl7. hypothetical protein. UniProt:Q26EG4 (EMBL:AAPD01000003 (268 aa) fasta scores: E()=5.6e-20, 46.512% id in 129 aa; similarity:fasta; with=UniProt:Q26EG4 (EMBL:AAPD01000003;); Flavobacteria bacterium BBFL7.; Hypothetical protein.; length=268; id 46.512%; ungapped id 48.387%; E()=5.6e-20; 129 aa overlap; query 1-125; subject 1-128 522373018268 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 522373018269 AAA domain; Region: AAA_30; pfam13604 522373018270 Family description; Region: UvrD_C_2; pfam13538 522373018271 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 522373018272 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 522373018273 HMMPfam hit to PF00580, UvrD/REP helicase, score 5.6e-65 522373018274 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 522373018275 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 522373018276 HMMPfam hit to PF04257, Exodeoxyribonuclease V, gamma subunit, score 0 522373018277 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 522373018278 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 522373018279 Walker A/P-loop; other site 522373018280 ATP binding site [chemical binding]; other site 522373018281 Q-loop/lid; other site 522373018282 ABC transporter signature motif; other site 522373018283 Walker B; other site 522373018284 D-loop; other site 522373018285 H-loop/switch region; other site 522373018286 HMMPfam hit to PF00005, ABC transporter score 2.8e-51 522373018287 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 522373018288 Permease; Region: Permease; pfam02405 522373018289 HMMPfam hit to PF02405, Domain of unknown function DUF140, score 8.2e-75 522373018290 5 probable transmembrane helices predicted for Smlt4671 by TMHMM2.0 at aa 45-67, 90-112, 138-160, 191-213 and 226-248 522373018291 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 522373018292 mce related protein; Region: MCE; pfam02470 522373018293 1 probable transmembrane helix predicted for Smlt4672 by TMHMM2.0 at aa 23-45 522373018294 HMMPfam hit to PF02470, mce related protein, score 8.5e-24 522373018295 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 522373018296 HMMPfam hit to PF05494, Toluene tolerance, Ttg2, score 3.2e-68 522373018297 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 522373018298 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 522373018299 HMMPfam hit to PF04333, VacJ like lipoprotein, score 3.2e-93 522373018300 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 522373018301 catalytic residues [active] 522373018302 dimer interface [polypeptide binding]; other site 522373018303 HMMPfam hit to PF00255, Glutathione peroxidase, score 1.2e-45 522373018304 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 522373018305 RmuC family; Region: RmuC; pfam02646 522373018306 HMMPfam hit to PF02646, RmuC family, score 1.4e-134 522373018307 1 probable transmembrane helix predicted for Smlt4678 by TMHMM2.0 at aa 5-24 522373018308 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 522373018309 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 522373018310 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 522373018311 putative N-terminal domain interface [polypeptide binding]; other site 522373018312 putative dimer interface [polypeptide binding]; other site 522373018313 putative substrate binding pocket (H-site) [chemical binding]; other site 522373018314 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 1.1e-09 522373018315 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 1.3e-08 522373018316 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 522373018317 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 522373018318 putative NAD(P) binding site [chemical binding]; other site 522373018319 dimer interface [polypeptide binding]; other site 522373018320 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 3.1e-07 522373018321 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 5.9e-11 522373018322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 522373018323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 522373018324 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 522373018325 putative effector binding pocket; other site 522373018326 dimerization interface [polypeptide binding]; other site 522373018327 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.2e-15 522373018328 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.9e-45 522373018329 LysE type translocator; Region: LysE; cl00565 522373018330 5 probable transmembrane helices predicted for Smlt4682 by TMHMM2.0 at aa 10-32, 45-67, 72-94, 118-140 and 150-172 522373018331 HMMPfam hit to PF01810, LysE type translocator, score 7.8e-37 522373018332 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 522373018333 amino acid transporter; Region: 2A0306; TIGR00909 522373018334 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 522373018335 13 probable transmembrane helices predicted for Smlt4685 by TMHMM2.0 at aa 53-75, 85-107, 128-150, 185-207, 214-236, 261-283, 296-318, 343-365, 386-408, 418-440, 453-470 and 475-494 522373018336 HMMPfam hit to PF00324, Amino acid permease, score 5.9e-32 522373018337 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 522373018338 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 522373018339 active site 522373018340 dimer interface [polypeptide binding]; other site 522373018341 HMMPfam hit to PF01244, Membrane dipeptidase (Peptidase family, score 1e-118 522373018342 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 522373018343 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 522373018344 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 522373018345 putative RNA binding site [nucleotide binding]; other site 522373018346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 522373018347 S-adenosylmethionine binding site [chemical binding]; other site 522373018348 HMMPfam hit to PF03602, Conserved hypothetical protein, score 0.0011 522373018349 HMMPfam hit to PF08241, Methyltransferase domain, score 0.0012 522373018350 HMMPfam hit to PF08242, Methyltransferase domain, score 0.0019 522373018351 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 522373018352 9 probable transmembrane helices predicted for Smlt4688 by TMHMM2.0 at aa 7-26, 41-63, 83-105, 115-137, 142-164, 199-221, 234-256, 261-278 and 285-307 522373018353 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 6.9e-62 522373018354 Rhomboid family; Region: Rhomboid; cl11446 522373018355 6 probable transmembrane helices predicted for Smlt4689 by TMHMM2.0 at aa 20-42, 72-94, 101-118, 122-144, 151-170 and 180-197 522373018356 HMMPfam hit to PF01694, Rhomboid family, score 1.1e-06 522373018357 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 522373018358 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 522373018359 active site 522373018360 catalytic site [active] 522373018361 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 6.1e-46 522373018362 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 522373018363 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 522373018364 trmE is a tRNA modification GTPase; Region: trmE; cd04164 522373018365 G1 box; other site 522373018366 GTP/Mg2+ binding site [chemical binding]; other site 522373018367 Switch I region; other site 522373018368 G2 box; other site 522373018369 Switch II region; other site 522373018370 G3 box; other site 522373018371 G4 box; other site 522373018372 G5 box; other site 522373018373 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 522373018374 HMMPfam hit to PF01926, GTPase of unknown function, score 3.5e-37 522373018375 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 522373018376 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 522373018377 NodB motif; other site 522373018378 active site 522373018379 catalytic site [active] 522373018380 metal binding site [ion binding]; metal-binding site 522373018381 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 522373018382 Caspase domain; Region: Peptidase_C14; pfam00656 522373018383 TPR repeat; Region: TPR_11; pfam13414 522373018384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 522373018385 TPR motif; other site 522373018386 binding surface 522373018387 TPR repeat; Region: TPR_11; pfam13414 522373018388 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 3.1e-05 522373018389 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 7.9e-06 522373018390 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.5e-05 522373018391 HMMPfam hit to PF00656, Caspase domain, score 3.7e-08 522373018392 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 4.6e-34 522373018393 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 522373018394 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 522373018395 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 522373018396 HMMPfam hit to PF02096, 60Kd inner membrane protein, score 4.2e-100 522373018397 5 probable transmembrane helices predicted for Smlt4693 by TMHMM2.0 at aa 7-24, 371-393, 437-459, 479-496 and 516-538 522373018398 ribonuclease P; Reviewed; Region: rnpA; PRK04820 522373018399 HMMPfam hit to PF00825, Ribonuclease P, score 2.9e-24 522373018400 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 522373018401 HMMPfam hit to PF00468, Ribosomal protein L34, score 3.4e-20