-- dump date   	20140620_080831
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
378806000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
378806000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
378806000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806000004	Walker A motif; other site
378806000005	ATP binding site [chemical binding]; other site
378806000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
378806000007	Walker B motif; other site
378806000008	arginine finger; other site
378806000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
378806000010	DnaA box-binding interface [nucleotide binding]; other site
378806000011	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806000012	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806000013	active site
378806000014	catalytic tetrad [active]
378806000015	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
378806000016	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
378806000017	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
378806000018	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
378806000019	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806000020	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806000021	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
378806000022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806000023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000024	active site
378806000025	phosphorylation site [posttranslational modification]
378806000026	intermolecular recognition site; other site
378806000027	dimerization interface [polypeptide binding]; other site
378806000028	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806000029	DNA binding site [nucleotide binding]
378806000030	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
378806000031	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
378806000032	dimer interface [polypeptide binding]; other site
378806000033	phosphorylation site [posttranslational modification]
378806000034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000035	ATP binding site [chemical binding]; other site
378806000036	Mg2+ binding site [ion binding]; other site
378806000037	G-X-G motif; other site
378806000038	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
378806000039	putative active site [active]
378806000040	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
378806000041	FOG: CBS domain [General function prediction only]; Region: COG0517
378806000042	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
378806000043	Secretin and TonB N terminus short domain; Region: STN; pfam07660
378806000044	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
378806000045	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000046	binding surface
378806000047	TPR motif; other site
378806000048	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000049	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000051	TPR motif; other site
378806000052	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000053	binding surface
378806000054	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000056	binding surface
378806000057	TPR motif; other site
378806000058	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000059	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000060	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000061	binding surface
378806000062	TPR motif; other site
378806000063	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000064	CHAT domain; Region: CHAT; pfam12770
378806000065	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806000066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806000067	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
378806000068	putative effector binding pocket; other site
378806000069	putative dimerization interface [polypeptide binding]; other site
378806000070	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806000071	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806000072	active site
378806000073	catalytic tetrad [active]
378806000074	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
378806000075	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
378806000076	Right handed beta helix region; Region: Beta_helix; pfam13229
378806000077	Right handed beta helix region; Region: Beta_helix; pfam13229
378806000078	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
378806000079	active site
378806000080	nucleophile elbow; other site
378806000081	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806000082	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806000083	active site
378806000084	Acyl transferase domain; Region: Acyl_transf_1; cl08282
378806000085	Methyltransferase domain; Region: Methyltransf_12; pfam08242
378806000086	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806000087	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
378806000088	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806000089	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
378806000090	acyl-activating enzyme (AAE) consensus motif; other site
378806000091	AMP binding site [chemical binding]; other site
378806000092	Condensation domain; Region: Condensation; pfam00668
378806000093	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806000094	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806000095	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806000096	The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906
378806000097	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
378806000098	acyl-activating enzyme (AAE) consensus motif; other site
378806000099	putative AMP binding site [chemical binding]; other site
378806000100	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
378806000101	putative NADP binding site [chemical binding]; other site
378806000102	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806000103	active site
378806000104	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806000105	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806000106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806000107	S-adenosylmethionine binding site [chemical binding]; other site
378806000108	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806000109	Cytochrome P450; Region: p450; cl12078
378806000110	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806000111	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806000112	active site
378806000113	ATP binding site [chemical binding]; other site
378806000114	substrate binding site [chemical binding]; other site
378806000115	activation loop (A-loop); other site
378806000116	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806000117	AAA ATPase domain; Region: AAA_16; pfam13191
378806000118	Predicted ATPase [General function prediction only]; Region: COG3899
378806000119	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806000120	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806000121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806000122	dimer interface [polypeptide binding]; other site
378806000123	phosphorylation site [posttranslational modification]
378806000124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000125	ATP binding site [chemical binding]; other site
378806000126	Mg2+ binding site [ion binding]; other site
378806000127	G-X-G motif; other site
378806000128	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806000129	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806000130	active site
378806000131	ATP binding site [chemical binding]; other site
378806000132	substrate binding site [chemical binding]; other site
378806000133	activation loop (A-loop); other site
378806000134	Response regulator receiver domain; Region: Response_reg; pfam00072
378806000135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000136	active site
378806000137	phosphorylation site [posttranslational modification]
378806000138	intermolecular recognition site; other site
378806000139	dimerization interface [polypeptide binding]; other site
378806000140	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
378806000141	cyclase homology domain; Region: CHD; cd07302
378806000142	nucleotidyl binding site; other site
378806000143	metal binding site [ion binding]; metal-binding site
378806000144	dimer interface [polypeptide binding]; other site
378806000145	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
378806000146	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806000147	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806000148	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806000149	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806000150	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806000151	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806000152	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806000153	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
378806000154	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
378806000155	active site
378806000156	nucleophile elbow; other site
378806000157	H+ Antiporter protein; Region: 2A0121; TIGR00900
378806000158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806000159	putative substrate translocation pore; other site
378806000160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000161	Response regulator receiver domain; Region: Response_reg; pfam00072
378806000162	active site
378806000163	phosphorylation site [posttranslational modification]
378806000164	intermolecular recognition site; other site
378806000165	dimerization interface [polypeptide binding]; other site
378806000166	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806000167	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806000168	dimer interface [polypeptide binding]; other site
378806000169	phosphorylation site [posttranslational modification]
378806000170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000171	ATP binding site [chemical binding]; other site
378806000172	Mg2+ binding site [ion binding]; other site
378806000173	G-X-G motif; other site
378806000174	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806000175	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806000176	active site
378806000177	ATP binding site [chemical binding]; other site
378806000178	substrate binding site [chemical binding]; other site
378806000179	activation loop (A-loop); other site
378806000180	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
378806000181	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819
378806000182	putative heme binding site [chemical binding]; other site
378806000183	putative substrate binding site [chemical binding]; other site
378806000184	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
378806000185	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806000186	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806000187	active site
378806000188	ATP binding site [chemical binding]; other site
378806000189	substrate binding site [chemical binding]; other site
378806000190	activation loop (A-loop); other site
378806000191	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000192	TPR repeat; Region: TPR_11; pfam13414
378806000193	binding surface
378806000194	TPR motif; other site
378806000195	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
378806000196	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
378806000197	putative active site [active]
378806000198	putative metal binding site [ion binding]; other site
378806000199	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
378806000200	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806000201	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
378806000202	dimerization interface [polypeptide binding]; other site
378806000203	substrate binding pocket [chemical binding]; other site
378806000204	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
378806000205	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806000206	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806000207	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
378806000208	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
378806000209	PYR/PP interface [polypeptide binding]; other site
378806000210	dimer interface [polypeptide binding]; other site
378806000211	TPP binding site [chemical binding]; other site
378806000212	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
378806000213	TPP-binding site [chemical binding]; other site
378806000214	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
378806000215	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
378806000216	DNA binding residues [nucleotide binding]
378806000217	dimer interface [polypeptide binding]; other site
378806000218	[2Fe-2S] cluster binding site [ion binding]; other site
378806000219	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
378806000220	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806000221	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
378806000222	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
378806000223	pyridoxamine kinase; Validated; Region: PRK05756
378806000224	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
378806000225	pyridoxal binding site [chemical binding]; other site
378806000226	dimer interface [polypeptide binding]; other site
378806000227	ATP binding site [chemical binding]; other site
378806000228	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
378806000229	hypothetical protein; Provisional; Region: PRK01184
378806000230	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
378806000231	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
378806000232	active site
378806000233	Zn binding site [ion binding]; other site
378806000234	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
378806000235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806000236	S-adenosylmethionine binding site [chemical binding]; other site
378806000237	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
378806000238	glutathione synthetase; Provisional; Region: PRK05246
378806000239	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
378806000240	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
378806000241	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806000242	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806000243	active site
378806000244	ATP binding site [chemical binding]; other site
378806000245	substrate binding site [chemical binding]; other site
378806000246	activation loop (A-loop); other site
378806000247	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806000248	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806000249	active site
378806000250	catalytic tetrad [active]
378806000251	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
378806000252	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806000253	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806000254	Proline dehydrogenase; Region: Pro_dh; cl03282
378806000255	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
378806000256	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
378806000257	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806000258	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806000259	active site
378806000260	ATP binding site [chemical binding]; other site
378806000261	substrate binding site [chemical binding]; other site
378806000262	activation loop (A-loop); other site
378806000263	PEGA domain; Region: PEGA; pfam08308
378806000264	NMT1-like family; Region: NMT1_2; pfam13379
378806000265	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
378806000266	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
378806000267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806000268	dimer interface [polypeptide binding]; other site
378806000269	conserved gate region; other site
378806000270	putative PBP binding loops; other site
378806000271	ABC-ATPase subunit interface; other site
378806000272	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
378806000273	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
378806000274	Walker A/P-loop; other site
378806000275	ATP binding site [chemical binding]; other site
378806000276	Q-loop/lid; other site
378806000277	ABC transporter signature motif; other site
378806000278	Walker B; other site
378806000279	D-loop; other site
378806000280	H-loop/switch region; other site
378806000281	Predicted metalloprotease [General function prediction only]; Region: COG2321
378806000282	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
378806000283	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
378806000284	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806000285	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806000286	DNA-binding site [nucleotide binding]; DNA binding site
378806000287	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806000288	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806000289	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
378806000290	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806000291	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
378806000292	Zn binding site [ion binding]; other site
378806000293	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
378806000294	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
378806000295	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
378806000296	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
378806000297	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
378806000298	Walker A/P-loop; other site
378806000299	ATP binding site [chemical binding]; other site
378806000300	Q-loop/lid; other site
378806000301	ABC transporter signature motif; other site
378806000302	Walker B; other site
378806000303	D-loop; other site
378806000304	H-loop/switch region; other site
378806000305	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
378806000306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806000307	dimer interface [polypeptide binding]; other site
378806000308	conserved gate region; other site
378806000309	ABC-ATPase subunit interface; other site
378806000310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806000311	dimer interface [polypeptide binding]; other site
378806000312	conserved gate region; other site
378806000313	putative PBP binding loops; other site
378806000314	ABC-ATPase subunit interface; other site
378806000315	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
378806000316	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
378806000317	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
378806000318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806000319	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806000320	Walker A motif; other site
378806000321	ATP binding site [chemical binding]; other site
378806000322	Walker B motif; other site
378806000323	arginine finger; other site
378806000324	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
378806000325	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
378806000326	Glucose dehydrogenase; Region: glucose_DH; cd08230
378806000327	NADP binding site [chemical binding]; other site
378806000328	catalytic Zn binding site [ion binding]; other site
378806000329	structural Zn binding site [ion binding]; other site
378806000330	dimer interface [polypeptide binding]; other site
378806000331	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806000332	GAF domain; Region: GAF; pfam01590
378806000333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806000334	PAS fold; Region: PAS_3; pfam08447
378806000335	putative active site [active]
378806000336	heme pocket [chemical binding]; other site
378806000337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806000338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806000339	dimer interface [polypeptide binding]; other site
378806000340	phosphorylation site [posttranslational modification]
378806000341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000342	ATP binding site [chemical binding]; other site
378806000343	Mg2+ binding site [ion binding]; other site
378806000344	G-X-G motif; other site
378806000345	Response regulator receiver domain; Region: Response_reg; pfam00072
378806000346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000347	active site
378806000348	phosphorylation site [posttranslational modification]
378806000349	intermolecular recognition site; other site
378806000350	dimerization interface [polypeptide binding]; other site
378806000351	Uncharacterized conserved protein [Function unknown]; Region: COG4850
378806000352	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
378806000353	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806000354	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
378806000355	PilZ domain; Region: PilZ; cl01260
378806000356	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
378806000357	hypothetical protein; Reviewed; Region: PRK09588
378806000358	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806000359	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
378806000360	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
378806000361	putative NAD(P) binding site [chemical binding]; other site
378806000362	putative substrate binding site [chemical binding]; other site
378806000363	catalytic Zn binding site [ion binding]; other site
378806000364	structural Zn binding site [ion binding]; other site
378806000365	dimer interface [polypeptide binding]; other site
378806000366	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
378806000367	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
378806000368	putative active site [active]
378806000369	catalytic site [active]
378806000370	putative metal binding site [ion binding]; other site
378806000371	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
378806000372	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806000373	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
378806000374	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806000375	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806000376	Amidohydrolase; Region: Amidohydro_4; pfam13147
378806000377	active site
378806000378	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806000379	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
378806000380	PA/protease or protease-like domain interface [polypeptide binding]; other site
378806000381	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
378806000382	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806000383	metal binding site [ion binding]; metal-binding site
378806000384	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
378806000385	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
378806000386	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
378806000387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806000388	Coenzyme A binding pocket [chemical binding]; other site
378806000389	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
378806000390	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
378806000391	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
378806000392	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
378806000393	tetrameric interface [polypeptide binding]; other site
378806000394	NAD binding site [chemical binding]; other site
378806000395	catalytic residues [active]
378806000396	hypothetical protein; Validated; Region: PRK07198
378806000397	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
378806000398	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
378806000399	dimerization interface [polypeptide binding]; other site
378806000400	active site
378806000401	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
378806000402	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
378806000403	active site
378806000404	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
378806000405	nucleophilic elbow; other site
378806000406	catalytic triad; other site
378806000407	potential frameshift: common BLAST hit: gi|251799209|ref|YP_003013940.1| coagulation factor 5/8 type domain protein
378806000408	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
378806000409	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
378806000410	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
378806000411	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
378806000412	putative active site [active]
378806000413	putative metal binding site [ion binding]; other site
378806000414	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806000415	AMP-binding enzyme; Region: AMP-binding; pfam00501
378806000416	acyl-activating enzyme (AAE) consensus motif; other site
378806000417	active site
378806000418	AMP binding site [chemical binding]; other site
378806000419	CoA binding site [chemical binding]; other site
378806000420	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
378806000421	active site
378806000422	8-oxo-dGMP binding site [chemical binding]; other site
378806000423	nudix motif; other site
378806000424	metal binding site [ion binding]; metal-binding site
378806000425	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
378806000426	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
378806000427	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
378806000428	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
378806000429	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
378806000430	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
378806000431	Penicillin amidase; Region: Penicil_amidase; pfam01804
378806000432	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
378806000433	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
378806000434	active site
378806000435	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
378806000436	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
378806000437	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
378806000438	Cl- selectivity filter; other site
378806000439	Cl- binding residues [ion binding]; other site
378806000440	pore gating glutamate residue; other site
378806000441	dimer interface [polypeptide binding]; other site
378806000442	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
378806000443	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
378806000444	putative active site [active]
378806000445	putative NTP binding site [chemical binding]; other site
378806000446	putative nucleic acid binding site [nucleotide binding]; other site
378806000447	SWIM zinc finger; Region: SWIM; pfam04434
378806000448	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806000449	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806000450	structural tetrad; other site
378806000451	HEAT repeats; Region: HEAT_2; pfam13646
378806000452	HEAT repeats; Region: HEAT_2; pfam13646
378806000453	HEAT repeats; Region: HEAT_2; pfam13646
378806000454	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
378806000455	Bacterial transcriptional activator domain; Region: BTAD; smart01043
378806000456	Predicted ATPase [General function prediction only]; Region: COG3899
378806000457	AAA ATPase domain; Region: AAA_16; pfam13191
378806000458	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806000459	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806000460	active site
378806000461	ATP binding site [chemical binding]; other site
378806000462	substrate binding site [chemical binding]; other site
378806000463	activation loop (A-loop); other site
378806000464	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
378806000465	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
378806000466	catalytic loop [active]
378806000467	iron binding site [ion binding]; other site
378806000468	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
378806000469	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806000470	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
378806000471	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
378806000472	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806000473	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806000474	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
378806000475	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
378806000476	phosphoserine phosphatase SerB; Region: serB; TIGR00338
378806000477	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806000478	motif II; other site
378806000479	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
378806000480	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
378806000481	ligand binding site [chemical binding]; other site
378806000482	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806000483	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806000484	DNA-binding site [nucleotide binding]; DNA binding site
378806000485	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806000486	short chain dehydrogenase; Provisional; Region: PRK08263
378806000487	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
378806000488	NADP binding site [chemical binding]; other site
378806000489	active site
378806000490	steroid binding site; other site
378806000491	Cupin; Region: Cupin_6; pfam12852
378806000492	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
378806000493	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
378806000494	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806000495	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
378806000496	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
378806000497	PA/protease or protease-like domain interface [polypeptide binding]; other site
378806000498	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
378806000499	metal binding site [ion binding]; metal-binding site
378806000500	Protein of unknown function (DUF808); Region: DUF808; pfam05661
378806000501	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
378806000502	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
378806000503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806000504	putative substrate translocation pore; other site
378806000505	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806000506	tRNA synthetases class II (A); Region: tRNA-synt_2c; pfam01411
378806000507	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
378806000508	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
378806000509	nucleotide binding site [chemical binding]; other site
378806000510	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806000511	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
378806000512	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
378806000513	Walker A/P-loop; other site
378806000514	ATP binding site [chemical binding]; other site
378806000515	Q-loop/lid; other site
378806000516	ABC transporter signature motif; other site
378806000517	Walker B; other site
378806000518	D-loop; other site
378806000519	H-loop/switch region; other site
378806000520	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
378806000521	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806000522	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
378806000523	TM-ABC transporter signature motif; other site
378806000524	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
378806000525	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
378806000526	putative ligand binding site [chemical binding]; other site
378806000527	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
378806000528	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
378806000529	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
378806000530	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806000531	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
378806000532	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
378806000533	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806000534	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806000535	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806000536	structural tetrad; other site
378806000537	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806000538	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806000539	structural tetrad; other site
378806000540	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806000541	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806000542	structural tetrad; other site
378806000543	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806000544	structural tetrad; other site
378806000545	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806000546	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806000547	structural tetrad; other site
378806000548	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806000549	structural tetrad; other site
378806000550	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806000551	structural tetrad; other site
378806000552	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806000553	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806000554	structural tetrad; other site
378806000555	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
378806000556	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806000557	active site
378806000558	metal binding site [ion binding]; metal-binding site
378806000559	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
378806000560	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
378806000561	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806000562	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
378806000563	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806000564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806000565	S-adenosylmethionine binding site [chemical binding]; other site
378806000566	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806000567	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000568	ATP binding site [chemical binding]; other site
378806000569	Mg2+ binding site [ion binding]; other site
378806000570	G-X-G motif; other site
378806000571	DNA methylase; Region: N6_N4_Mtase; cl17433
378806000572	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806000573	TPR motif; other site
378806000574	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
378806000575	Fic family protein [Function unknown]; Region: COG3177
378806000576	Fic/DOC family; Region: Fic; pfam02661
378806000577	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
378806000578	active site
378806000579	phosphorylation site [posttranslational modification]
378806000580	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
378806000581	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
378806000582	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
378806000583	Soluble P-type ATPase [General function prediction only]; Region: COG4087
378806000584	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
378806000585	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
378806000586	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
378806000587	Ligand Binding Site [chemical binding]; other site
378806000588	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806000589	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806000590	dimerization interface [polypeptide binding]; other site
378806000591	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806000592	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806000593	dimer interface [polypeptide binding]; other site
378806000594	phosphorylation site [posttranslational modification]
378806000595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000596	ATP binding site [chemical binding]; other site
378806000597	Mg2+ binding site [ion binding]; other site
378806000598	G-X-G motif; other site
378806000599	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806000600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000601	active site
378806000602	phosphorylation site [posttranslational modification]
378806000603	intermolecular recognition site; other site
378806000604	dimerization interface [polypeptide binding]; other site
378806000605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806000606	Walker A motif; other site
378806000607	ATP binding site [chemical binding]; other site
378806000608	Walker B motif; other site
378806000609	arginine finger; other site
378806000610	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806000611	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806000612	dimerization interface [polypeptide binding]; other site
378806000613	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806000614	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806000615	dimer interface [polypeptide binding]; other site
378806000616	putative CheW interface [polypeptide binding]; other site
378806000617	type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898
378806000618	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
378806000619	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
378806000620	active site
378806000621	zinc binding site [ion binding]; other site
378806000622	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806000623	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806000624	DNA-binding site [nucleotide binding]; DNA binding site
378806000625	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
378806000626	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806000627	Coenzyme A binding pocket [chemical binding]; other site
378806000628	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
378806000629	active site
378806000630	catalytic triad [active]
378806000631	oxyanion hole [active]
378806000632	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
378806000633	generic binding surface II; other site
378806000634	generic binding surface I; other site
378806000635	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
378806000636	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
378806000637	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
378806000638	cofactor binding site; other site
378806000639	DNA binding site [nucleotide binding]
378806000640	substrate interaction site [chemical binding]; other site
378806000641	potential frameshift: common BLAST hit: gi|108758771|ref|YP_628458.1| formate--tetrahydrofolate ligase
378806000642	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
378806000643	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
378806000644	Potassium binding sites [ion binding]; other site
378806000645	Cesium cation binding sites [ion binding]; other site
378806000646	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806000647	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806000648	Erythromycin esterase; Region: Erythro_esteras; pfam05139
378806000649	SnoaL-like domain; Region: SnoaL_3; pfam13474
378806000650	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
378806000651	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806000652	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
378806000653	AsmA family; Region: AsmA; pfam05170
378806000654	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
378806000655	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
378806000656	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000657	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806000658	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000659	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000660	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806000661	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000662	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000663	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000664	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000665	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000666	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000667	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000668	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806000669	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
378806000670	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782
378806000671	CHAT domain; Region: CHAT; pfam12770
378806000672	Domain of unknown function DUF11; Region: DUF11; pfam01345
378806000673	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
378806000674	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806000675	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806000676	ligand binding site [chemical binding]; other site
378806000677	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
378806000678	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
378806000679	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
378806000680	putative NAD(P) binding site [chemical binding]; other site
378806000681	hypothetical protein; Provisional; Region: PRK06834
378806000682	hypothetical protein; Provisional; Region: PRK07236
378806000683	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806000684	RibD C-terminal domain; Region: RibD_C; cl17279
378806000685	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806000686	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
378806000687	Cytochrome P450; Region: p450; cl12078
378806000688	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806000689	Cytochrome P450; Region: p450; cl12078
378806000690	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806000691	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000692	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000693	binding surface
378806000694	TPR motif; other site
378806000695	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000696	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000697	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000698	TPR motif; other site
378806000699	binding surface
378806000700	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000701	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000702	binding surface
378806000703	TPR motif; other site
378806000704	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000705	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000706	binding surface
378806000707	TPR motif; other site
378806000708	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000709	CHAT domain; Region: CHAT; pfam12770
378806000710	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806000711	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
378806000712	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
378806000713	substrate binding [chemical binding]; other site
378806000714	active site
378806000715	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
378806000716	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806000717	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806000718	active site
378806000719	ATP binding site [chemical binding]; other site
378806000720	substrate binding site [chemical binding]; other site
378806000721	activation loop (A-loop); other site
378806000722	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000723	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000724	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000725	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000726	binding surface
378806000727	TPR motif; other site
378806000728	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806000729	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
378806000730	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
378806000731	metal ion-dependent adhesion site (MIDAS); other site
378806000732	PAS domain S-box; Region: sensory_box; TIGR00229
378806000733	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806000734	putative active site [active]
378806000735	heme pocket [chemical binding]; other site
378806000736	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806000737	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806000738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806000739	PAS fold; Region: PAS_3; pfam08447
378806000740	putative active site [active]
378806000741	heme pocket [chemical binding]; other site
378806000742	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806000743	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806000744	dimer interface [polypeptide binding]; other site
378806000745	phosphorylation site [posttranslational modification]
378806000746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000747	ATP binding site [chemical binding]; other site
378806000748	Mg2+ binding site [ion binding]; other site
378806000749	G-X-G motif; other site
378806000750	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806000751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000752	active site
378806000753	phosphorylation site [posttranslational modification]
378806000754	intermolecular recognition site; other site
378806000755	dimerization interface [polypeptide binding]; other site
378806000756	GAF domain; Region: GAF; cl17456
378806000757	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806000758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000759	ATP binding site [chemical binding]; other site
378806000760	Mg2+ binding site [ion binding]; other site
378806000761	G-X-G motif; other site
378806000762	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
378806000763	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
378806000764	active site residue [active]
378806000765	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
378806000766	Subtilase family; Region: Peptidase_S8; pfam00082
378806000767	active site
378806000768	catalytic residues [active]
378806000769	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
378806000770	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806000771	NAD(P) binding site [chemical binding]; other site
378806000772	active site
378806000773	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
378806000774	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806000775	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806000776	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
378806000777	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
378806000778	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
378806000779	dimer interface [polypeptide binding]; other site
378806000780	active site
378806000781	CoA binding pocket [chemical binding]; other site
378806000782	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806000783	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
378806000784	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
378806000785	acyl-activating enzyme (AAE) consensus motif; other site
378806000786	acyl-activating enzyme (AAE) consensus motif; other site
378806000787	putative AMP binding site [chemical binding]; other site
378806000788	putative active site [active]
378806000789	putative CoA binding site [chemical binding]; other site
378806000790	hypothetical protein; Region: PHA01818
378806000791	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
378806000792	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806000793	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
378806000794	Lipase (class 2); Region: Lipase_2; pfam01674
378806000795	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
378806000796	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806000797	dimerization interface [polypeptide binding]; other site
378806000798	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806000799	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806000800	dimer interface [polypeptide binding]; other site
378806000801	putative CheW interface [polypeptide binding]; other site
378806000802	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806000803	sequence-specific DNA binding site [nucleotide binding]; other site
378806000804	salt bridge; other site
378806000805	Response regulator receiver domain; Region: Response_reg; pfam00072
378806000806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000807	active site
378806000808	phosphorylation site [posttranslational modification]
378806000809	intermolecular recognition site; other site
378806000810	dimerization interface [polypeptide binding]; other site
378806000811	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
378806000812	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806000813	dimer interface [polypeptide binding]; other site
378806000814	phosphorylation site [posttranslational modification]
378806000815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000816	ATP binding site [chemical binding]; other site
378806000817	Mg2+ binding site [ion binding]; other site
378806000818	G-X-G motif; other site
378806000819	Response regulator receiver domain; Region: Response_reg; pfam00072
378806000820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000821	active site
378806000822	phosphorylation site [posttranslational modification]
378806000823	intermolecular recognition site; other site
378806000824	dimerization interface [polypeptide binding]; other site
378806000825	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806000826	dimer interface [polypeptide binding]; other site
378806000827	phosphorylation site [posttranslational modification]
378806000828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000829	ATP binding site [chemical binding]; other site
378806000830	Mg2+ binding site [ion binding]; other site
378806000831	G-X-G motif; other site
378806000832	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806000833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000834	active site
378806000835	phosphorylation site [posttranslational modification]
378806000836	intermolecular recognition site; other site
378806000837	dimerization interface [polypeptide binding]; other site
378806000838	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806000839	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000840	active site
378806000841	phosphorylation site [posttranslational modification]
378806000842	intermolecular recognition site; other site
378806000843	dimerization interface [polypeptide binding]; other site
378806000844	B12 binding domain; Region: B12-binding_2; pfam02607
378806000845	B12 binding domain; Region: B12-binding; pfam02310
378806000846	B12 binding site [chemical binding]; other site
378806000847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806000848	Coenzyme A binding pocket [chemical binding]; other site
378806000849	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
378806000850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000851	ATP binding site [chemical binding]; other site
378806000852	Mg2+ binding site [ion binding]; other site
378806000853	G-X-G motif; other site
378806000854	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
378806000855	anchoring element; other site
378806000856	dimer interface [polypeptide binding]; other site
378806000857	ATP binding site [chemical binding]; other site
378806000858	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
378806000859	active site
378806000860	putative metal-binding site [ion binding]; other site
378806000861	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
378806000862	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806000863	Walker A/P-loop; other site
378806000864	ATP binding site [chemical binding]; other site
378806000865	AAA domain; Region: AAA_21; pfam13304
378806000866	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
378806000867	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
378806000868	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
378806000869	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
378806000870	dimer interface [polypeptide binding]; other site
378806000871	putative functional site; other site
378806000872	putative MPT binding site; other site
378806000873	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
378806000874	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
378806000875	GTP binding site; other site
378806000876	PAS domain; Region: PAS; smart00091
378806000877	PAS fold; Region: PAS_4; pfam08448
378806000878	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806000879	PAS domain; Region: PAS_8; pfam13188
378806000880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806000881	dimer interface [polypeptide binding]; other site
378806000882	phosphorylation site [posttranslational modification]
378806000883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806000884	ATP binding site [chemical binding]; other site
378806000885	Mg2+ binding site [ion binding]; other site
378806000886	G-X-G motif; other site
378806000887	Response regulator receiver domain; Region: Response_reg; pfam00072
378806000888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000889	active site
378806000890	phosphorylation site [posttranslational modification]
378806000891	intermolecular recognition site; other site
378806000892	dimerization interface [polypeptide binding]; other site
378806000893	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806000894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806000895	Walker A motif; other site
378806000896	ATP binding site [chemical binding]; other site
378806000897	Walker B motif; other site
378806000898	arginine finger; other site
378806000899	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806000900	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806000901	active site
378806000902	ATP binding site [chemical binding]; other site
378806000903	substrate binding site [chemical binding]; other site
378806000904	activation loop (A-loop); other site
378806000905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000906	TPR motif; other site
378806000907	binding surface
378806000908	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806000909	binding surface
378806000910	TPR motif; other site
378806000911	Proline dehydrogenase; Region: Pro_dh; cl03282
378806000912	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
378806000913	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806000914	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
378806000915	putative acyl-acceptor binding pocket; other site
378806000916	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
378806000917	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806000918	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806000919	ligand binding site [chemical binding]; other site
378806000920	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806000921	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806000922	ligand binding site [chemical binding]; other site
378806000923	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806000924	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806000925	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806000926	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806000927	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806000928	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806000929	MYXO-CTERM domain; Region: MYXO-CTERM; TIGR03901
378806000930	Response regulator receiver domain; Region: Response_reg; pfam00072
378806000931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806000932	active site
378806000933	phosphorylation site [posttranslational modification]
378806000934	intermolecular recognition site; other site
378806000935	dimerization interface [polypeptide binding]; other site
378806000936	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806000937	cyclase homology domain; Region: CHD; cd07302
378806000938	nucleotidyl binding site; other site
378806000939	metal binding site [ion binding]; metal-binding site
378806000940	dimer interface [polypeptide binding]; other site
378806000941	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
378806000942	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806000943	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
378806000944	putative ADP-ribose binding site [chemical binding]; other site
378806000945	putative active site [active]
378806000946	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
378806000947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806000948	S-adenosylmethionine binding site [chemical binding]; other site
378806000949	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806000950	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806000951	catalytic residue [active]
378806000952	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806000953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806000954	homodimer interface [polypeptide binding]; other site
378806000955	catalytic residue [active]
378806000956	Cupin domain; Region: Cupin_2; pfam07883
378806000957	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
378806000958	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
378806000959	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
378806000960	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806000961	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806000962	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806000963	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
378806000964	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806000965	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806000966	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806000967	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806000968	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806000969	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806000970	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806000971	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806000972	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
378806000973	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806000974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
378806000975	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806000976	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
378806000977	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806000978	DNA-binding site [nucleotide binding]; DNA binding site
378806000979	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
378806000980	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
378806000981	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806000982	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806000983	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
378806000984	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
378806000985	Cu(I) binding site [ion binding]; other site
378806000986	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
378806000987	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
378806000988	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
378806000989	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
378806000990	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806000991	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806000992	catalytic residue [active]
378806000993	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
378806000994	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
378806000995	Protein kinase domain; Region: Pkinase; pfam00069
378806000996	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806000997	active site
378806000998	ATP binding site [chemical binding]; other site
378806000999	substrate binding site [chemical binding]; other site
378806001000	activation loop (A-loop); other site
378806001001	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
378806001002	putative hydrophobic ligand binding site [chemical binding]; other site
378806001003	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806001004	dimerization interface [polypeptide binding]; other site
378806001005	putative DNA binding site [nucleotide binding]; other site
378806001006	putative Zn2+ binding site [ion binding]; other site
378806001007	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
378806001008	dimer interface [polypeptide binding]; other site
378806001009	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806001010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806001011	S-adenosylmethionine binding site [chemical binding]; other site
378806001012	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806001013	putative metal binding site [ion binding]; other site
378806001014	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
378806001015	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
378806001016	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
378806001017	substrate binding pocket [chemical binding]; other site
378806001018	membrane-bound complex binding site; other site
378806001019	hinge residues; other site
378806001020	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806001021	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
378806001022	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
378806001023	Chromate transporter; Region: Chromate_transp; pfam02417
378806001024	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806001025	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806001026	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
378806001027	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
378806001028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806001029	conserved gate region; other site
378806001030	putative PBP binding loops; other site
378806001031	ABC-ATPase subunit interface; other site
378806001032	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
378806001033	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
378806001034	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
378806001035	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
378806001036	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
378806001037	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
378806001038	active site
378806001039	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
378806001040	dimer interface [polypeptide binding]; other site
378806001041	active site
378806001042	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
378806001043	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806001044	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
378806001045	acyl-activating enzyme (AAE) consensus motif; other site
378806001046	acyl-activating enzyme (AAE) consensus motif; other site
378806001047	putative AMP binding site [chemical binding]; other site
378806001048	putative active site [active]
378806001049	putative CoA binding site [chemical binding]; other site
378806001050	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
378806001051	Thioredoxin; Region: Thioredoxin_4; pfam13462
378806001052	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
378806001053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806001054	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806001055	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
378806001056	Beta/Gamma crystallin; Region: Crystall; cl02528
378806001057	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
378806001058	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806001059	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
378806001060	protein-splicing catalytic site; other site
378806001061	thioester formation/cholesterol transfer; other site
378806001062	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
378806001063	Cytochrome c; Region: Cytochrom_C; cl11414
378806001064	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806001065	PAS domain; Region: PAS_9; pfam13426
378806001066	putative active site [active]
378806001067	heme pocket [chemical binding]; other site
378806001068	GAF domain; Region: GAF_2; pfam13185
378806001069	GAF domain; Region: GAF; pfam01590
378806001070	PAS domain; Region: PAS_9; pfam13426
378806001071	PAS domain S-box; Region: sensory_box; TIGR00229
378806001072	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806001073	putative active site [active]
378806001074	heme pocket [chemical binding]; other site
378806001075	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806001076	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806001077	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806001078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806001079	dimer interface [polypeptide binding]; other site
378806001080	phosphorylation site [posttranslational modification]
378806001081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806001082	ATP binding site [chemical binding]; other site
378806001083	Mg2+ binding site [ion binding]; other site
378806001084	G-X-G motif; other site
378806001085	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806001086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001087	active site
378806001088	phosphorylation site [posttranslational modification]
378806001089	intermolecular recognition site; other site
378806001090	dimerization interface [polypeptide binding]; other site
378806001091	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
378806001092	active site
378806001093	catalytic site [active]
378806001094	substrate binding site [chemical binding]; other site
378806001095	DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417
378806001096	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
378806001097	active site
378806001098	metal-binding site
378806001099	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
378806001100	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806001101	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
378806001102	putative active site [active]
378806001103	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806001104	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
378806001105	SnoaL-like domain; Region: SnoaL_2; pfam12680
378806001106	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
378806001107	dimer interface [polypeptide binding]; other site
378806001108	substrate binding site [chemical binding]; other site
378806001109	ATP binding site [chemical binding]; other site
378806001110	FOG: CBS domain [General function prediction only]; Region: COG0517
378806001111	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
378806001112	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
378806001113	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
378806001114	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
378806001115	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
378806001116	P loop; other site
378806001117	Nucleotide binding site [chemical binding]; other site
378806001118	DTAP/Switch II; other site
378806001119	Switch I; other site
378806001120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
378806001121	Coenzyme A binding pocket [chemical binding]; other site
378806001122	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
378806001123	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806001124	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806001125	Cytochrome P450; Region: p450; cl12078
378806001126	Hpt domain; Region: Hpt; pfam01627
378806001127	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001129	active site
378806001130	phosphorylation site [posttranslational modification]
378806001131	intermolecular recognition site; other site
378806001132	dimerization interface [polypeptide binding]; other site
378806001133	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001135	active site
378806001136	phosphorylation site [posttranslational modification]
378806001137	intermolecular recognition site; other site
378806001138	dimerization interface [polypeptide binding]; other site
378806001139	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
378806001140	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806001141	Coenzyme A binding pocket [chemical binding]; other site
378806001142	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
378806001143	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
378806001144	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
378806001145	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
378806001146	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
378806001147	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
378806001148	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
378806001149	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
378806001150	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
378806001151	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
378806001152	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
378806001153	antimicrobial peptide system protein, SdpB family; Region: export_SdpB; TIGR04033
378806001154	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
378806001155	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
378806001156	putative heme binding pocket [chemical binding]; other site
378806001157	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
378806001158	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
378806001159	catalytic core [active]
378806001160	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
378806001161	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
378806001162	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
378806001163	Zn binding site [ion binding]; other site
378806001164	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806001165	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806001166	active site
378806001167	catalytic tetrad [active]
378806001168	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806001169	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
378806001170	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806001171	PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820
378806001172	PA/protease or protease-like domain interface [polypeptide binding]; other site
378806001173	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661
378806001174	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806001175	metal binding site [ion binding]; metal-binding site
378806001176	SOUL heme-binding protein; Region: SOUL; pfam04832
378806001177	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806001178	sugar binding site [chemical binding]; other site
378806001179	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
378806001180	putative metal binding site [ion binding]; other site
378806001181	CARDB; Region: CARDB; pfam07705
378806001182	CARDB; Region: CARDB; pfam07705
378806001183	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
378806001184	putative metal binding site [ion binding]; other site
378806001185	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
378806001186	Predicted ATPase [General function prediction only]; Region: COG4637
378806001187	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
378806001188	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
378806001189	TPP-binding site [chemical binding]; other site
378806001190	dimer interface [polypeptide binding]; other site
378806001191	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
378806001192	PYR/PP interface [polypeptide binding]; other site
378806001193	dimer interface [polypeptide binding]; other site
378806001194	TPP binding site [chemical binding]; other site
378806001195	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
378806001196	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806001197	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806001198	PilZ domain; Region: PilZ; pfam07238
378806001199	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806001200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806001201	Walker A motif; other site
378806001202	ATP binding site [chemical binding]; other site
378806001203	Walker B motif; other site
378806001204	arginine finger; other site
378806001205	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806001206	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
378806001207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001208	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001209	active site
378806001210	phosphorylation site [posttranslational modification]
378806001211	intermolecular recognition site; other site
378806001212	dimerization interface [polypeptide binding]; other site
378806001213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001214	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806001215	active site
378806001216	phosphorylation site [posttranslational modification]
378806001217	intermolecular recognition site; other site
378806001218	dimerization interface [polypeptide binding]; other site
378806001219	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806001220	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806001221	putative active site [active]
378806001222	heme pocket [chemical binding]; other site
378806001223	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
378806001224	dimer interface [polypeptide binding]; other site
378806001225	phosphorylation site [posttranslational modification]
378806001226	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806001227	ATP binding site [chemical binding]; other site
378806001228	Mg2+ binding site [ion binding]; other site
378806001229	G-X-G motif; other site
378806001230	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806001231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001232	active site
378806001233	phosphorylation site [posttranslational modification]
378806001234	intermolecular recognition site; other site
378806001235	dimerization interface [polypeptide binding]; other site
378806001236	CARDB; Region: CARDB; pfam07705
378806001237	Protein of unknown function (DUF504); Region: DUF504; cl00661
378806001238	Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080
378806001239	putative catalytic site [active]
378806001240	putative metal binding site [ion binding]; other site
378806001241	putative phosphate binding site [ion binding]; other site
378806001242	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
378806001243	Poly(A) polymerase central domain; Region: PAP_central; pfam04928
378806001244	Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402
378806001245	active site
378806001246	putative primer-binding pocket; other site
378806001247	metal binding triad [ion binding]; metal-binding site
378806001248	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
378806001249	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806001250	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806001251	active site
378806001252	ATP binding site [chemical binding]; other site
378806001253	substrate binding site [chemical binding]; other site
378806001254	activation loop (A-loop); other site
378806001255	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
378806001256	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
378806001257	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
378806001258	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
378806001259	Cu(I) binding site [ion binding]; other site
378806001260	Protein of unknown function (DUF461); Region: DUF461; pfam04314
378806001261	Cytochrome c; Region: Cytochrom_C; cl11414
378806001262	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806001263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001264	active site
378806001265	phosphorylation site [posttranslational modification]
378806001266	intermolecular recognition site; other site
378806001267	dimerization interface [polypeptide binding]; other site
378806001268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001269	active site
378806001270	phosphorylation site [posttranslational modification]
378806001271	intermolecular recognition site; other site
378806001272	dimerization interface [polypeptide binding]; other site
378806001273	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806001274	PAS fold; Region: PAS_3; pfam08447
378806001275	putative active site [active]
378806001276	heme pocket [chemical binding]; other site
378806001277	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806001278	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806001279	dimer interface [polypeptide binding]; other site
378806001280	phosphorylation site [posttranslational modification]
378806001281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806001282	ATP binding site [chemical binding]; other site
378806001283	G-X-G motif; other site
378806001284	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
378806001285	active site
378806001286	catalytic residues [active]
378806001287	metal binding site [ion binding]; metal-binding site
378806001288	SlyX; Region: SlyX; pfam04102
378806001289	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806001290	binding surface
378806001291	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806001292	TPR motif; other site
378806001293	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
378806001294	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806001295	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806001296	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806001297	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
378806001298	active site
378806001299	catalytic residues [active]
378806001300	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
378806001301	PA/protease or protease-like domain interface [polypeptide binding]; other site
378806001302	Subtilase family; Region: Peptidase_S8; pfam00082
378806001303	catalytic residues [active]
378806001304	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
378806001305	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806001306	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806001307	DNA binding residues [nucleotide binding]
378806001308	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
378806001309	PRC-barrel domain; Region: PRC; pfam05239
378806001310	CheW-like domain; Region: CheW; pfam01584
378806001311	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
378806001312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806001313	S-adenosylmethionine binding site [chemical binding]; other site
378806001314	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806001315	TPR motif; other site
378806001316	binding surface
378806001317	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806001318	CHASE3 domain; Region: CHASE3; pfam05227
378806001319	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806001320	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806001321	dimer interface [polypeptide binding]; other site
378806001322	putative CheW interface [polypeptide binding]; other site
378806001323	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806001324	putative binding surface; other site
378806001325	active site
378806001326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806001327	ATP binding site [chemical binding]; other site
378806001328	Mg2+ binding site [ion binding]; other site
378806001329	G-X-G motif; other site
378806001330	CheW-like domain; Region: CheW; pfam01584
378806001331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001332	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001333	active site
378806001334	phosphorylation site [posttranslational modification]
378806001335	intermolecular recognition site; other site
378806001336	dimerization interface [polypeptide binding]; other site
378806001337	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
378806001338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001339	active site
378806001340	phosphorylation site [posttranslational modification]
378806001341	intermolecular recognition site; other site
378806001342	dimerization interface [polypeptide binding]; other site
378806001343	CheB methylesterase; Region: CheB_methylest; pfam01339
378806001344	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001346	active site
378806001347	phosphorylation site [posttranslational modification]
378806001348	intermolecular recognition site; other site
378806001349	dimerization interface [polypeptide binding]; other site
378806001350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001351	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001352	active site
378806001353	phosphorylation site [posttranslational modification]
378806001354	intermolecular recognition site; other site
378806001355	dimerization interface [polypeptide binding]; other site
378806001356	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806001357	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806001358	putative active site [active]
378806001359	heme pocket [chemical binding]; other site
378806001360	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806001361	dimer interface [polypeptide binding]; other site
378806001362	phosphorylation site [posttranslational modification]
378806001363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806001364	ATP binding site [chemical binding]; other site
378806001365	Mg2+ binding site [ion binding]; other site
378806001366	G-X-G motif; other site
378806001367	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806001368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001369	active site
378806001370	phosphorylation site [posttranslational modification]
378806001371	intermolecular recognition site; other site
378806001372	dimerization interface [polypeptide binding]; other site
378806001373	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
378806001374	cleavage site
378806001375	active site
378806001376	substrate binding sites [chemical binding]; other site
378806001377	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806001378	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
378806001379	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
378806001380	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806001381	active site
378806001382	ATP binding site [chemical binding]; other site
378806001383	GAF domain; Region: GAF_3; pfam13492
378806001384	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
378806001385	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806001386	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806001387	dimer interface [polypeptide binding]; other site
378806001388	phosphorylation site [posttranslational modification]
378806001389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806001390	ATP binding site [chemical binding]; other site
378806001391	Mg2+ binding site [ion binding]; other site
378806001392	G-X-G motif; other site
378806001393	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806001394	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
378806001395	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
378806001396	HipA-like N-terminal domain; Region: HipA_N; pfam07805
378806001397	HipA-like C-terminal domain; Region: HipA_C; pfam07804
378806001398	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
378806001399	EVE domain; Region: EVE; cl00728
378806001400	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806001401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806001402	Walker A motif; other site
378806001403	ATP binding site [chemical binding]; other site
378806001404	Walker B motif; other site
378806001405	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
378806001406	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
378806001407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806001408	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806001409	putative substrate translocation pore; other site
378806001410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806001411	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
378806001412	Kelch domain; Region: Kelch; smart00612
378806001413	Kelch motif; Region: Kelch_1; pfam01344
378806001414	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806001415	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806001416	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806001417	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
378806001418	active site
378806001419	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001421	active site
378806001422	phosphorylation site [posttranslational modification]
378806001423	intermolecular recognition site; other site
378806001424	dimerization interface [polypeptide binding]; other site
378806001425	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
378806001426	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806001427	Walker A motif; other site
378806001428	ATP binding site [chemical binding]; other site
378806001429	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806001430	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806001431	Walker A motif; other site
378806001432	ATP binding site [chemical binding]; other site
378806001433	Walker B motif; other site
378806001434	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
378806001435	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
378806001436	homodimer interface [polypeptide binding]; other site
378806001437	substrate-cofactor binding pocket; other site
378806001438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806001439	catalytic residue [active]
378806001440	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
378806001441	Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983
378806001442	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
378806001443	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806001444	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806001445	putative sugar binding sites [chemical binding]; other site
378806001446	Q-X-W motif; other site
378806001447	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
378806001448	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
378806001449	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
378806001450	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
378806001451	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
378806001452	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
378806001453	conserved cys residue [active]
378806001454	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806001455	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806001456	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
378806001457	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806001458	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806001459	putative sugar binding sites [chemical binding]; other site
378806001460	Q-X-W motif; other site
378806001461	Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983
378806001462	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
378806001463	CARDB; Region: CARDB; pfam07705
378806001464	CARDB; Region: CARDB; pfam07705
378806001465	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663
378806001466	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
378806001467	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
378806001468	UreF; Region: UreF; pfam01730
378806001469	urease subunit alpha; Reviewed; Region: ureC; PRK13207
378806001470	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
378806001471	subunit interactions [polypeptide binding]; other site
378806001472	active site
378806001473	flap region; other site
378806001474	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
378806001475	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
378806001476	alpha-gamma subunit interface [polypeptide binding]; other site
378806001477	beta-gamma subunit interface [polypeptide binding]; other site
378806001478	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
378806001479	alpha-beta subunit interface [polypeptide binding]; other site
378806001480	UreD urease accessory protein; Region: UreD; pfam01774
378806001481	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
378806001482	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806001483	active site
378806001484	HIGH motif; other site
378806001485	nucleotide binding site [chemical binding]; other site
378806001486	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
378806001487	active site
378806001488	KMSKS motif; other site
378806001489	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
378806001490	tRNA binding surface [nucleotide binding]; other site
378806001491	anticodon binding site; other site
378806001492	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
378806001493	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806001494	putative substrate translocation pore; other site
378806001495	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806001496	Cytochrome P450; Region: p450; pfam00067
378806001497	Cupin-like domain; Region: Cupin_8; pfam13621
378806001498	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
378806001499	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
378806001500	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
378806001501	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
378806001502	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806001503	catalytic residue [active]
378806001504	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
378806001505	GH3 auxin-responsive promoter; Region: GH3; pfam03321
378806001506	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
378806001507	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
378806001508	catalytic triad [active]
378806001509	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
378806001510	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806001511	FeS/SAM binding site; other site
378806001512	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
378806001513	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806001514	B12 binding domain; Region: B12-binding; pfam02310
378806001515	B12 binding site [chemical binding]; other site
378806001516	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
378806001517	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806001518	FeS/SAM binding site; other site
378806001519	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806001520	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806001521	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806001522	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
378806001523	active site
378806001524	catalytic triad [active]
378806001525	oxyanion hole [active]
378806001526	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
378806001527	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806001528	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806001529	active site
378806001530	catalytic tetrad [active]
378806001531	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
378806001532	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
378806001533	catalytic residues [active]
378806001534	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
378806001535	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
378806001536	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
378806001537	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
378806001538	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
378806001539	active site
378806001540	catalytic residues [active]
378806001541	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
378806001542	Subtilase family; Region: Peptidase_S8; pfam00082
378806001543	catalytic residues [active]
378806001544	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
378806001545	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806001546	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806001547	active site
378806001548	ATP binding site [chemical binding]; other site
378806001549	substrate binding site [chemical binding]; other site
378806001550	activation loop (A-loop); other site
378806001551	RDD family; Region: RDD; cl00746
378806001552	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806001553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001554	active site
378806001555	phosphorylation site [posttranslational modification]
378806001556	intermolecular recognition site; other site
378806001557	dimerization interface [polypeptide binding]; other site
378806001558	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806001559	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806001560	phosphopeptide binding site; other site
378806001561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806001562	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806001563	Walker A motif; other site
378806001564	ATP binding site [chemical binding]; other site
378806001565	Walker B motif; other site
378806001566	arginine finger; other site
378806001567	Uncharacterized conserved protein [Function unknown]; Region: COG2968
378806001568	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
378806001569	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806001570	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806001571	dimer interface [polypeptide binding]; other site
378806001572	putative CheW interface [polypeptide binding]; other site
378806001573	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
378806001574	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
378806001575	PEGA domain; Region: PEGA; pfam08308
378806001576	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
378806001577	nudix motif; other site
378806001578	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
378806001579	Protein phosphatase 2C; Region: PP2C_2; pfam13672
378806001580	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
378806001581	Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335
378806001582	catalytic triad [active]
378806001583	conserved cis-peptide bond; other site
378806001584	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432
378806001585	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806001586	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806001587	dimerization interface [polypeptide binding]; other site
378806001588	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806001589	dimer interface [polypeptide binding]; other site
378806001590	phosphorylation site [posttranslational modification]
378806001591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806001592	ATP binding site [chemical binding]; other site
378806001593	Mg2+ binding site [ion binding]; other site
378806001594	G-X-G motif; other site
378806001595	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
378806001596	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
378806001597	active site
378806001598	thioredoxin 2; Provisional; Region: PRK10996
378806001599	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
378806001600	catalytic residues [active]
378806001601	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
378806001602	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806001603	RNA binding surface [nucleotide binding]; other site
378806001604	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806001605	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806001606	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
378806001607	DNA binding residues [nucleotide binding]
378806001608	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
378806001609	DNA polymerase III subunit beta; Validated; Region: PRK05643
378806001610	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
378806001611	putative DNA binding surface [nucleotide binding]; other site
378806001612	dimer interface [polypeptide binding]; other site
378806001613	beta-clamp/clamp loader binding surface; other site
378806001614	beta-clamp/translesion DNA polymerase binding surface; other site
378806001615	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
378806001616	recombination protein F; Reviewed; Region: recF; PRK00064
378806001617	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806001618	Walker A/P-loop; other site
378806001619	ATP binding site [chemical binding]; other site
378806001620	Q-loop/lid; other site
378806001621	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806001622	ABC transporter signature motif; other site
378806001623	Walker B; other site
378806001624	D-loop; other site
378806001625	H-loop/switch region; other site
378806001626	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
378806001627	Permease; Region: Permease; pfam02405
378806001628	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
378806001629	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
378806001630	Walker A/P-loop; other site
378806001631	ATP binding site [chemical binding]; other site
378806001632	Q-loop/lid; other site
378806001633	ABC transporter signature motif; other site
378806001634	Walker B; other site
378806001635	D-loop; other site
378806001636	H-loop/switch region; other site
378806001637	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
378806001638	mce related protein; Region: MCE; pfam02470
378806001639	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
378806001640	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806001641	DNA-binding site [nucleotide binding]; DNA binding site
378806001642	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806001643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806001644	homodimer interface [polypeptide binding]; other site
378806001645	catalytic residue [active]
378806001646	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
378806001647	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806001648	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
378806001649	putative C-terminal domain interface [polypeptide binding]; other site
378806001650	putative GSH binding site (G-site) [chemical binding]; other site
378806001651	putative dimer interface [polypeptide binding]; other site
378806001652	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
378806001653	dimer interface [polypeptide binding]; other site
378806001654	N-terminal domain interface [polypeptide binding]; other site
378806001655	putative substrate binding pocket (H-site) [chemical binding]; other site
378806001656	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
378806001657	sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377
378806001658	hydroxyglutarate oxidase; Provisional; Region: PRK11728
378806001659	Winged helix-turn helix; Region: HTH_33; pfam13592
378806001660	potential frameshift: common BLAST hit: gi|108759312|ref|YP_629493.1| Ser/Thr kinase family protein
378806001661	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806001662	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806001663	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806001664	active site
378806001665	ATP binding site [chemical binding]; other site
378806001666	substrate binding site [chemical binding]; other site
378806001667	activation loop (A-loop); other site
378806001668	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806001669	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
378806001670	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806001671	Cellulose binding domain; Region: CBM_3; cl03026
378806001672	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
378806001673	active site
378806001674	catalytic residues [active]
378806001675	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806001676	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806001677	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806001678	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806001679	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806001680	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
378806001681	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
378806001682	putative ADP-binding pocket [chemical binding]; other site
378806001683	Uncharacterized conserved protein [Function unknown]; Region: COG3791
378806001684	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
378806001685	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806001686	catalytic residue [active]
378806001687	circadian clock protein KaiC; Reviewed; Region: PRK09302
378806001688	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806001689	Walker A motif; other site
378806001690	ATP binding site [chemical binding]; other site
378806001691	Walker B motif; other site
378806001692	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806001693	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806001694	Walker A motif; other site
378806001695	Walker A motif; other site
378806001696	ATP binding site [chemical binding]; other site
378806001697	Walker B motif; other site
378806001698	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001700	active site
378806001701	phosphorylation site [posttranslational modification]
378806001702	intermolecular recognition site; other site
378806001703	dimerization interface [polypeptide binding]; other site
378806001704	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
378806001705	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
378806001706	active site
378806001707	metal binding site [ion binding]; metal-binding site
378806001708	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
378806001709	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
378806001710	active site
378806001711	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
378806001712	dimer interface [polypeptide binding]; other site
378806001713	substrate binding site [chemical binding]; other site
378806001714	catalytic residues [active]
378806001715	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
378806001716	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
378806001717	putative acyl-acceptor binding pocket; other site
378806001718	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
378806001719	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
378806001720	Zn binding site [ion binding]; other site
378806001721	enoyl-CoA hydratase; Provisional; Region: PRK06688
378806001722	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806001723	substrate binding site [chemical binding]; other site
378806001724	oxyanion hole (OAH) forming residues; other site
378806001725	trimer interface [polypeptide binding]; other site
378806001726	Cupin domain; Region: Cupin_2; cl17218
378806001727	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
378806001728	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
378806001729	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
378806001730	catalytic site [active]
378806001731	putative active site [active]
378806001732	putative substrate binding site [chemical binding]; other site
378806001733	dimer interface [polypeptide binding]; other site
378806001734	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001736	active site
378806001737	phosphorylation site [posttranslational modification]
378806001738	intermolecular recognition site; other site
378806001739	dimerization interface [polypeptide binding]; other site
378806001740	circadian clock protein KaiC; Reviewed; Region: PRK09302
378806001741	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806001742	Walker A motif; other site
378806001743	ATP binding site [chemical binding]; other site
378806001744	Walker B motif; other site
378806001745	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806001746	Walker A motif; other site
378806001747	ATP binding site [chemical binding]; other site
378806001748	Walker B motif; other site
378806001749	Protein of unknown function (DUF2378); Region: DUF2378; cl15288
378806001750	Response regulator receiver domain; Region: Response_reg; pfam00072
378806001751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001752	active site
378806001753	phosphorylation site [posttranslational modification]
378806001754	intermolecular recognition site; other site
378806001755	dimerization interface [polypeptide binding]; other site
378806001756	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806001757	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806001758	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806001759	GAF domain; Region: GAF; pfam01590
378806001760	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806001761	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806001762	dimer interface [polypeptide binding]; other site
378806001763	phosphorylation site [posttranslational modification]
378806001764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806001765	ATP binding site [chemical binding]; other site
378806001766	Mg2+ binding site [ion binding]; other site
378806001767	G-X-G motif; other site
378806001768	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
378806001769	GRAS family transcription factor; Region: GRAS; pfam03514
378806001770	Competence-damaged protein; Region: CinA; pfam02464
378806001771	Family description; Region: UvrD_C_2; pfam13538
378806001772	EF-hand domain pair; Region: EF_hand_5; pfam13499
378806001773	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
378806001774	Ca2+ binding site [ion binding]; other site
378806001775	HipA N-terminal domain; Region: Couple_hipA; pfam13657
378806001776	HipA-like N-terminal domain; Region: HipA_N; pfam07805
378806001777	HipA-like C-terminal domain; Region: HipA_C; pfam07804
378806001778	Protein of unknown function DUF262; Region: DUF262; pfam03235
378806001779	Uncharacterized conserved protein [Function unknown]; Region: COG1479
378806001780	Uncharacterized conserved protein [Function unknown]; Region: COG3472
378806001781	CARDB; Region: CARDB; pfam07705
378806001782	CARDB; Region: CARDB; pfam07705
378806001783	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
378806001784	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
378806001785	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
378806001786	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
378806001787	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806001788	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806001789	active site
378806001790	catalytic tetrad [active]
378806001791	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
378806001792	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
378806001793	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
378806001794	GSH binding site [chemical binding]; other site
378806001795	catalytic residues [active]
378806001796	SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381
378806001797	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
378806001798	R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297
378806001799	RxxxH motif; other site
378806001800	5' nucleotidase family; Region: 5_nucleotid; pfam05761
378806001801	SEC-C motif; Region: SEC-C; pfam02810
378806001802	methionine aminopeptidase; Provisional; Region: PRK12318
378806001803	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
378806001804	active site
378806001805	Isochorismatase family; Region: Isochorismatase; pfam00857
378806001806	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
378806001807	catalytic triad [active]
378806001808	dimer interface [polypeptide binding]; other site
378806001809	conserved cis-peptide bond; other site
378806001810	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
378806001811	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
378806001812	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
378806001813	SIR2-like domain; Region: SIR2_2; pfam13289
378806001814	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806001815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806001816	NAD(P) binding site [chemical binding]; other site
378806001817	active site
378806001818	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
378806001819	putative active site [active]
378806001820	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806001821	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806001822	DNA-binding site [nucleotide binding]; DNA binding site
378806001823	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806001824	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806001825	active site
378806001826	ATP binding site [chemical binding]; other site
378806001827	substrate binding site [chemical binding]; other site
378806001828	activation loop (A-loop); other site
378806001829	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
378806001830	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
378806001831	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
378806001832	TMP-binding site; other site
378806001833	ATP-binding site [chemical binding]; other site
378806001834	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
378806001835	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
378806001836	putative active site; other site
378806001837	putative triphosphate binding site [ion binding]; other site
378806001838	putative metal binding residues [ion binding]; other site
378806001839	CotH protein; Region: CotH; pfam08757
378806001840	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806001841	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806001842	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806001843	Kelch domain; Region: Kelch; smart00612
378806001844	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806001845	Kelch domain; Region: Kelch; smart00612
378806001846	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806001847	Kelch domain; Region: Kelch; smart00612
378806001848	Kelch motif; Region: Kelch_1; pfam01344
378806001849	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806001850	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
378806001851	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
378806001852	Phospholipid methyltransferase; Region: PEMT; cl17370
378806001853	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806001854	extended (e) SDRs; Region: SDR_e; cd08946
378806001855	NAD(P) binding site [chemical binding]; other site
378806001856	active site
378806001857	substrate binding site [chemical binding]; other site
378806001858	phosphoenolpyruvate synthase; Validated; Region: PRK06241
378806001859	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
378806001860	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
378806001861	prenyltransferase; Provisional; Region: ubiA; PRK13592
378806001862	multidrug efflux protein; Reviewed; Region: PRK09579
378806001863	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806001864	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806001865	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806001866	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
378806001867	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
378806001868	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806001869	putative sugar binding sites [chemical binding]; other site
378806001870	Q-X-W motif; other site
378806001871	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806001872	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
378806001873	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
378806001874	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
378806001875	hypothetical protein; Provisional; Region: PRK09133
378806001876	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
378806001877	putative metal binding site [ion binding]; other site
378806001878	Patatin-like phospholipase; Region: Patatin; pfam01734
378806001879	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
378806001880	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
378806001881	active site
378806001882	Protein of unknown function (DUF819); Region: DUF819; cl02317
378806001883	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
378806001884	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
378806001885	active site
378806001886	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806001887	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806001888	active site
378806001889	catalytic tetrad [active]
378806001890	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
378806001891	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806001892	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806001893	catalytic residue [active]
378806001894	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
378806001895	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806001896	putative acyl-acceptor binding pocket; other site
378806001897	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
378806001898	homotrimer interaction site [polypeptide binding]; other site
378806001899	putative active site [active]
378806001900	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
378806001901	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806001902	active site
378806001903	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
378806001904	RNA/DNA hybrid binding site [nucleotide binding]; other site
378806001905	active site
378806001906	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806001907	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806001908	phosphopeptide binding site; other site
378806001909	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806001910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806001911	Walker A motif; other site
378806001912	ATP binding site [chemical binding]; other site
378806001913	Walker B motif; other site
378806001914	arginine finger; other site
378806001915	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
378806001916	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806001917	active site
378806001918	ATP binding site [chemical binding]; other site
378806001919	substrate binding site [chemical binding]; other site
378806001920	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806001921	activation loop (A-loop); other site
378806001922	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806001923	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806001924	active site
378806001925	ATP binding site [chemical binding]; other site
378806001926	substrate binding site [chemical binding]; other site
378806001927	activation loop (A-loop); other site
378806001928	AAA ATPase domain; Region: AAA_16; pfam13191
378806001929	AAA domain; Region: AAA_22; pfam13401
378806001930	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806001931	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
378806001932	active site
378806001933	catalytic triad [active]
378806001934	oxyanion hole [active]
378806001935	Predicted transcriptional regulators [Transcription]; Region: COG1695
378806001936	Transcriptional regulator PadR-like family; Region: PadR; cl17335
378806001937	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806001938	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806001939	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806001940	active site
378806001941	ATP binding site [chemical binding]; other site
378806001942	substrate binding site [chemical binding]; other site
378806001943	activation loop (A-loop); other site
378806001944	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806001945	Predicted ATPase [General function prediction only]; Region: COG4637
378806001946	Walker A/P-loop; other site
378806001947	ATP binding site [chemical binding]; other site
378806001948	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806001949	ABC transporter signature motif; other site
378806001950	Walker B; other site
378806001951	D-loop; other site
378806001952	H-loop/switch region; other site
378806001953	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
378806001954	oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728
378806001955	OPT oligopeptide transporter protein; Region: OPT; pfam03169
378806001956	OPT oligopeptide transporter protein; Region: OPT; cl14607
378806001957	Double zinc ribbon; Region: DZR; pfam12773
378806001958	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806001959	cyclase homology domain; Region: CHD; cd07302
378806001960	nucleotidyl binding site; other site
378806001961	metal binding site [ion binding]; metal-binding site
378806001962	dimer interface [polypeptide binding]; other site
378806001963	Predicted ATPase [General function prediction only]; Region: COG3899
378806001964	AAA ATPase domain; Region: AAA_16; pfam13191
378806001965	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806001966	TPR motif; other site
378806001967	binding surface
378806001968	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806001969	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806001970	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806001971	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806001972	metal binding site [ion binding]; metal-binding site
378806001973	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806001974	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806001975	phosphopeptide binding site; other site
378806001976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806001977	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806001978	Walker A motif; other site
378806001979	ATP binding site [chemical binding]; other site
378806001980	Walker B motif; other site
378806001981	arginine finger; other site
378806001982	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806001983	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
378806001984	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806001985	DNA binding residues [nucleotide binding]
378806001986	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806001987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806001988	active site
378806001989	phosphorylation site [posttranslational modification]
378806001990	intermolecular recognition site; other site
378806001991	dimerization interface [polypeptide binding]; other site
378806001992	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806001993	DNA binding site [nucleotide binding]
378806001994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806001995	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806001996	dimer interface [polypeptide binding]; other site
378806001997	phosphorylation site [posttranslational modification]
378806001998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806001999	ATP binding site [chemical binding]; other site
378806002000	Mg2+ binding site [ion binding]; other site
378806002001	G-X-G motif; other site
378806002002	von Willebrand factor; Region: vWF_A; pfam12450
378806002003	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
378806002004	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
378806002005	metal ion-dependent adhesion site (MIDAS); other site
378806002006	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
378806002007	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
378806002008	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806002009	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
378806002010	Peptidase family M48; Region: Peptidase_M48; cl12018
378806002011	CHASE2 domain; Region: CHASE2; pfam05226
378806002012	CHASE2 domain; Region: CHASE2; pfam05226
378806002013	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806002014	cyclase homology domain; Region: CHD; cd07302
378806002015	nucleotidyl binding site; other site
378806002016	metal binding site [ion binding]; metal-binding site
378806002017	dimer interface [polypeptide binding]; other site
378806002018	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
378806002019	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
378806002020	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806002021	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806002022	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
378806002023	putative di-iron ligands [ion binding]; other site
378806002024	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806002025	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806002026	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806002027	DNA binding residues [nucleotide binding]
378806002028	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
378806002029	dimer interface [polypeptide binding]; other site
378806002030	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806002031	S-adenosylmethionine binding site [chemical binding]; other site
378806002032	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002033	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806002034	binding surface
378806002035	TPR motif; other site
378806002036	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002037	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002038	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806002039	binding surface
378806002040	TPR motif; other site
378806002041	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002042	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002043	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806002044	binding surface
378806002045	TPR motif; other site
378806002046	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002047	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806002048	binding surface
378806002049	TPR motif; other site
378806002050	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002051	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002052	CHAT domain; Region: CHAT; pfam12770
378806002053	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
378806002054	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
378806002055	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
378806002056	Protein of unknown function (DUF962); Region: DUF962; pfam06127
378806002057	methionine sulfoxide reductase A; Provisional; Region: PRK00058
378806002058	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
378806002059	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
378806002060	active site
378806002061	metal binding site [ion binding]; metal-binding site
378806002062	GAF domain; Region: GAF; pfam01590
378806002063	GAF domain; Region: GAF_2; pfam13185
378806002064	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806002065	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002066	dimer interface [polypeptide binding]; other site
378806002067	phosphorylation site [posttranslational modification]
378806002068	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002069	ATP binding site [chemical binding]; other site
378806002070	Mg2+ binding site [ion binding]; other site
378806002071	G-X-G motif; other site
378806002072	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
378806002073	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
378806002074	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
378806002075	NmrA-like family; Region: NmrA; pfam05368
378806002076	NADP binding site [chemical binding]; other site
378806002077	active site
378806002078	regulatory binding site [polypeptide binding]; other site
378806002079	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
378806002080	Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969
378806002081	SprT-like family; Region: SprT-like; pfam10263
378806002082	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
378806002083	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
378806002084	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
378806002085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806002086	S-adenosylmethionine binding site [chemical binding]; other site
378806002087	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806002088	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806002089	ligand binding site [chemical binding]; other site
378806002090	flexible hinge region; other site
378806002091	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806002092	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806002093	ligand binding site [chemical binding]; other site
378806002094	flexible hinge region; other site
378806002095	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806002096	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806002097	ligand binding site [chemical binding]; other site
378806002098	flexible hinge region; other site
378806002099	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806002100	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806002101	active site
378806002102	catalytic tetrad [active]
378806002103	SEC-C motif; Region: SEC-C; pfam02810
378806002104	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
378806002105	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
378806002106	iron-sulfur cluster [ion binding]; other site
378806002107	[2Fe-2S] cluster binding site [ion binding]; other site
378806002108	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
378806002109	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806002110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002111	active site
378806002112	phosphorylation site [posttranslational modification]
378806002113	intermolecular recognition site; other site
378806002114	dimerization interface [polypeptide binding]; other site
378806002115	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806002116	Walker A motif; other site
378806002117	ATP binding site [chemical binding]; other site
378806002118	Walker B motif; other site
378806002119	arginine finger; other site
378806002120	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806002121	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806002122	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002123	dimer interface [polypeptide binding]; other site
378806002124	phosphorylation site [posttranslational modification]
378806002125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002126	ATP binding site [chemical binding]; other site
378806002127	Mg2+ binding site [ion binding]; other site
378806002128	G-X-G motif; other site
378806002129	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
378806002130	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806002131	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806002132	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
378806002133	Walker A/P-loop; other site
378806002134	ATP binding site [chemical binding]; other site
378806002135	Q-loop/lid; other site
378806002136	ABC transporter signature motif; other site
378806002137	Walker B; other site
378806002138	D-loop; other site
378806002139	H-loop/switch region; other site
378806002140	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
378806002141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806002142	Walker A/P-loop; other site
378806002143	ATP binding site [chemical binding]; other site
378806002144	Q-loop/lid; other site
378806002145	ABC transporter signature motif; other site
378806002146	Walker B; other site
378806002147	D-loop; other site
378806002148	H-loop/switch region; other site
378806002149	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
378806002150	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
378806002151	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
378806002152	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
378806002153	acyl-CoA synthetase; Validated; Region: PRK05850
378806002154	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806002155	acyl-activating enzyme (AAE) consensus motif; other site
378806002156	active site
378806002157	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806002158	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
378806002159	active site
378806002160	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
378806002161	Glutamine amidotransferase class-I; Region: GATase; pfam00117
378806002162	glutamine binding [chemical binding]; other site
378806002163	catalytic triad [active]
378806002164	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
378806002165	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
378806002166	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
378806002167	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
378806002168	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806002169	acyl-activating enzyme (AAE) consensus motif; other site
378806002170	AMP binding site [chemical binding]; other site
378806002171	active site
378806002172	CoA binding site [chemical binding]; other site
378806002173	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
378806002174	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
378806002175	homodimer interface [polypeptide binding]; other site
378806002176	substrate-cofactor binding pocket; other site
378806002177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806002178	catalytic residue [active]
378806002179	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
378806002180	hydrophobic ligand binding site; other site
378806002181	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
378806002182	Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262
378806002183	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
378806002184	active site
378806002185	nucleophile elbow; other site
378806002186	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
378806002187	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
378806002188	Ligand binding site; other site
378806002189	metal-binding site
378806002190	H+ Antiporter protein; Region: 2A0121; TIGR00900
378806002191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806002192	putative substrate translocation pore; other site
378806002193	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806002194	ligand binding site [chemical binding]; other site
378806002195	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
378806002196	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
378806002197	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
378806002198	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
378806002199	beta subunit interaction interface [polypeptide binding]; other site
378806002200	Walker A motif; other site
378806002201	ATP binding site [chemical binding]; other site
378806002202	Walker B motif; other site
378806002203	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
378806002204	PAS fold; Region: PAS_4; pfam08448
378806002205	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806002206	PAS domain; Region: PAS_9; pfam13426
378806002207	putative active site [active]
378806002208	heme pocket [chemical binding]; other site
378806002209	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806002210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002211	ATP binding site [chemical binding]; other site
378806002212	Mg2+ binding site [ion binding]; other site
378806002213	G-X-G motif; other site
378806002214	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
378806002215	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
378806002216	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
378806002217	nucleotide binding site [chemical binding]; other site
378806002218	putative NEF/HSP70 interaction site [polypeptide binding]; other site
378806002219	SBD interface [polypeptide binding]; other site
378806002220	Response regulator receiver domain; Region: Response_reg; pfam00072
378806002221	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002222	active site
378806002223	phosphorylation site [posttranslational modification]
378806002224	intermolecular recognition site; other site
378806002225	dimerization interface [polypeptide binding]; other site
378806002226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002227	active site
378806002228	phosphorylation site [posttranslational modification]
378806002229	intermolecular recognition site; other site
378806002230	PilZ domain; Region: PilZ; cl01260
378806002231	Beta propeller domain; Region: Beta_propel; pfam09826
378806002232	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
378806002233	multidrug efflux protein; Reviewed; Region: PRK01766
378806002234	cation binding site [ion binding]; other site
378806002235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
378806002236	Putative esterase; Region: Esterase; pfam00756
378806002237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806002238	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806002239	Walker A motif; other site
378806002240	ATP binding site [chemical binding]; other site
378806002241	Walker B motif; other site
378806002242	arginine finger; other site
378806002243	Tetratricopeptide repeat; Region: TPR_10; pfam13374
378806002244	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002245	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806002246	binding surface
378806002247	TPR motif; other site
378806002248	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002249	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002250	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806002251	binding surface
378806002252	TPR motif; other site
378806002253	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002254	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002255	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806002256	binding surface
378806002257	TPR motif; other site
378806002258	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002259	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806002260	CHAT domain; Region: CHAT; pfam12770
378806002261	Protein kinase domain; Region: Pkinase; pfam00069
378806002262	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806002263	active site
378806002264	ATP binding site [chemical binding]; other site
378806002265	substrate binding site [chemical binding]; other site
378806002266	activation loop (A-loop); other site
378806002267	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
378806002268	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
378806002269	NADP binding site [chemical binding]; other site
378806002270	active site
378806002271	steroid binding site; other site
378806002272	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
378806002273	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
378806002274	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806002275	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806002276	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806002277	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806002278	active site
378806002279	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806002280	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806002281	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806002282	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806002283	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
378806002284	inhibitor-cofactor binding pocket; inhibition site
378806002285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806002286	catalytic residue [active]
378806002287	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
378806002288	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
378806002289	Condensation domain; Region: Condensation; pfam00668
378806002290	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806002291	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806002292	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
378806002293	acyl-activating enzyme (AAE) consensus motif; other site
378806002294	AMP binding site [chemical binding]; other site
378806002295	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806002296	Thioesterase domain; Region: Thioesterase; pfam00975
378806002297	Cytochrome P450; Region: p450; cl12078
378806002298	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806002299	acyl-CoA synthetase; Validated; Region: PRK05850
378806002300	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806002301	acyl-activating enzyme (AAE) consensus motif; other site
378806002302	active site
378806002303	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806002304	short chain dehydrogenase; Provisional; Region: PRK06172
378806002305	classical (c) SDRs; Region: SDR_c; cd05233
378806002306	NAD(P) binding site [chemical binding]; other site
378806002307	active site
378806002308	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
378806002309	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
378806002310	active site
378806002311	Zn binding site [ion binding]; other site
378806002312	hypothetical protein; Provisional; Region: PRK12378
378806002313	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
378806002314	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806002315	Kelch motif; Region: Kelch_6; pfam13964
378806002316	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806002317	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806002318	NAD(P) binding site [chemical binding]; other site
378806002319	active site
378806002320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806002321	S-adenosylmethionine binding site [chemical binding]; other site
378806002322	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
378806002323	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806002324	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
378806002325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
378806002326	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806002327	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806002328	active site
378806002329	ATP binding site [chemical binding]; other site
378806002330	substrate binding site [chemical binding]; other site
378806002331	activation loop (A-loop); other site
378806002332	AAA ATPase domain; Region: AAA_16; pfam13191
378806002333	TPR repeat; Region: TPR_11; pfam13414
378806002334	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806002335	binding surface
378806002336	TPR motif; other site
378806002337	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
378806002338	Domain of unknown function (DUF4215); Region: DUF4215; pfam13948
378806002339	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806002340	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806002341	Response regulator receiver domain; Region: Response_reg; pfam00072
378806002342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002343	active site
378806002344	phosphorylation site [posttranslational modification]
378806002345	intermolecular recognition site; other site
378806002346	dimerization interface [polypeptide binding]; other site
378806002347	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806002348	PAS domain; Region: PAS_9; pfam13426
378806002349	putative active site [active]
378806002350	heme pocket [chemical binding]; other site
378806002351	PAS domain; Region: PAS_9; pfam13426
378806002352	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806002353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002354	dimer interface [polypeptide binding]; other site
378806002355	phosphorylation site [posttranslational modification]
378806002356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002357	ATP binding site [chemical binding]; other site
378806002358	Mg2+ binding site [ion binding]; other site
378806002359	G-X-G motif; other site
378806002360	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806002361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002362	active site
378806002363	phosphorylation site [posttranslational modification]
378806002364	intermolecular recognition site; other site
378806002365	dimerization interface [polypeptide binding]; other site
378806002366	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806002367	active site
378806002368	ATP binding site [chemical binding]; other site
378806002369	substrate binding site [chemical binding]; other site
378806002370	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806002371	substrate binding site [chemical binding]; other site
378806002372	activation loop (A-loop); other site
378806002373	activation loop (A-loop); other site
378806002374	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806002375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806002376	non-specific DNA binding site [nucleotide binding]; other site
378806002377	salt bridge; other site
378806002378	sequence-specific DNA binding site [nucleotide binding]; other site
378806002379	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
378806002380	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806002381	Cna protein B-type domain; Region: Cna_B_2; pfam13715
378806002382	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
378806002383	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806002384	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806002385	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002386	dimer interface [polypeptide binding]; other site
378806002387	phosphorylation site [posttranslational modification]
378806002388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002389	ATP binding site [chemical binding]; other site
378806002390	Mg2+ binding site [ion binding]; other site
378806002391	G-X-G motif; other site
378806002392	Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289
378806002393	Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535
378806002394	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806002395	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806002396	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
378806002397	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806002398	putative active site [active]
378806002399	putative metal binding site [ion binding]; other site
378806002400	TonB C terminal; Region: TonB_2; pfam13103
378806002401	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
378806002402	metal binding site 2 [ion binding]; metal-binding site
378806002403	putative DNA binding helix; other site
378806002404	metal binding site 1 [ion binding]; metal-binding site
378806002405	dimer interface [polypeptide binding]; other site
378806002406	structural Zn2+ binding site [ion binding]; other site
378806002407	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
378806002408	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
378806002409	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
378806002410	Response regulator receiver domain; Region: Response_reg; pfam00072
378806002411	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002412	active site
378806002413	phosphorylation site [posttranslational modification]
378806002414	intermolecular recognition site; other site
378806002415	dimerization interface [polypeptide binding]; other site
378806002416	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806002417	PAS fold; Region: PAS_3; pfam08447
378806002418	putative active site [active]
378806002419	heme pocket [chemical binding]; other site
378806002420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806002421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002422	dimer interface [polypeptide binding]; other site
378806002423	phosphorylation site [posttranslational modification]
378806002424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002425	ATP binding site [chemical binding]; other site
378806002426	Mg2+ binding site [ion binding]; other site
378806002427	G-X-G motif; other site
378806002428	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
378806002429	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
378806002430	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806002431	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806002432	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806002433	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806002434	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806002435	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806002436	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806002437	Response regulator receiver domain; Region: Response_reg; pfam00072
378806002438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002439	active site
378806002440	phosphorylation site [posttranslational modification]
378806002441	intermolecular recognition site; other site
378806002442	dimerization interface [polypeptide binding]; other site
378806002443	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806002444	putative binding surface; other site
378806002445	active site
378806002446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002447	ATP binding site [chemical binding]; other site
378806002448	Mg2+ binding site [ion binding]; other site
378806002449	G-X-G motif; other site
378806002450	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806002451	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806002452	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806002453	dimer interface [polypeptide binding]; other site
378806002454	putative CheW interface [polypeptide binding]; other site
378806002455	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806002456	HEAT repeats; Region: HEAT_2; pfam13646
378806002457	HEAT repeats; Region: HEAT_2; pfam13646
378806002458	HEAT repeats; Region: HEAT_2; pfam13646
378806002459	HEAT repeats; Region: HEAT_2; pfam13646
378806002460	HEAT repeats; Region: HEAT_2; pfam13646
378806002461	HEAT repeats; Region: HEAT_2; pfam13646
378806002462	HEAT repeats; Region: HEAT_2; pfam13646
378806002463	HEAT repeats; Region: HEAT_2; pfam13646
378806002464	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
378806002465	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
378806002466	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
378806002467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002468	active site
378806002469	phosphorylation site [posttranslational modification]
378806002470	intermolecular recognition site; other site
378806002471	CheB methylesterase; Region: CheB_methylest; pfam01339
378806002472	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806002473	PAS fold; Region: PAS_3; pfam08447
378806002474	putative active site [active]
378806002475	heme pocket [chemical binding]; other site
378806002476	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
378806002477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002478	dimer interface [polypeptide binding]; other site
378806002479	phosphorylation site [posttranslational modification]
378806002480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002481	ATP binding site [chemical binding]; other site
378806002482	Mg2+ binding site [ion binding]; other site
378806002483	G-X-G motif; other site
378806002484	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
378806002485	beta-galactosidase; Region: BGL; TIGR03356
378806002486	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806002487	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806002488	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002489	dimer interface [polypeptide binding]; other site
378806002490	phosphorylation site [posttranslational modification]
378806002491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002492	ATP binding site [chemical binding]; other site
378806002493	Mg2+ binding site [ion binding]; other site
378806002494	G-X-G motif; other site
378806002495	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
378806002496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002497	active site
378806002498	phosphorylation site [posttranslational modification]
378806002499	intermolecular recognition site; other site
378806002500	dimerization interface [polypeptide binding]; other site
378806002501	CheB methylesterase; Region: CheB_methylest; pfam01339
378806002502	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806002503	putative binding surface; other site
378806002504	active site
378806002505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002506	ATP binding site [chemical binding]; other site
378806002507	Mg2+ binding site [ion binding]; other site
378806002508	G-X-G motif; other site
378806002509	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806002510	Response regulator receiver domain; Region: Response_reg; pfam00072
378806002511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002512	active site
378806002513	phosphorylation site [posttranslational modification]
378806002514	intermolecular recognition site; other site
378806002515	dimerization interface [polypeptide binding]; other site
378806002516	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
378806002517	CHASE3 domain; Region: CHASE3; cl05000
378806002518	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806002519	dimerization interface [polypeptide binding]; other site
378806002520	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806002521	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806002522	dimer interface [polypeptide binding]; other site
378806002523	putative CheW interface [polypeptide binding]; other site
378806002524	CheW-like domain; Region: CheW; pfam01584
378806002525	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
378806002526	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
378806002527	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
378806002528	phytoene desaturase; Region: crtI_fam; TIGR02734
378806002529	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806002530	Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556
378806002531	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806002532	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806002533	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
378806002534	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806002535	active site
378806002536	ATP binding site [chemical binding]; other site
378806002537	substrate binding site [chemical binding]; other site
378806002538	activation loop (A-loop); other site
378806002539	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806002540	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806002541	active site
378806002542	ATP binding site [chemical binding]; other site
378806002543	substrate binding site [chemical binding]; other site
378806002544	activation loop (A-loop); other site
378806002545	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806002546	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806002547	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
378806002548	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806002549	Interdomain contacts; other site
378806002550	Cytokine receptor motif; other site
378806002551	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
378806002552	protein-splicing catalytic site; other site
378806002553	thioester formation/cholesterol transfer; other site
378806002554	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
378806002555	Phage major tail protein 2; Region: Phage_tail_2; cl11463
378806002556	Phage capsid family; Region: Phage_capsid; pfam05065
378806002557	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
378806002558	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
378806002559	Phage-related protein [Function unknown]; Region: COG4695; cl01923
378806002560	Uncharacterized conserved protein [Function unknown]; Region: COG5323
378806002561	Terminase-like family; Region: Terminase_6; pfam03237
378806002562	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
378806002563	Virulence-associated protein E; Region: VirE; pfam05272
378806002564	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
378806002565	DNA methylase; Region: N6_N4_Mtase; cl17433
378806002566	DNA methylase; Region: N6_N4_Mtase; pfam01555
378806002567	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
378806002568	Superinfection exclusion protein B; Region: SieB; pfam14163
378806002569	Superfamily II helicase [General function prediction only]; Region: COG1204
378806002570	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806002571	active site
378806002572	ATP binding site [chemical binding]; other site
378806002573	substrate binding site [chemical binding]; other site
378806002574	activation loop (A-loop); other site
378806002575	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
378806002576	active site
378806002577	DNA binding site [nucleotide binding]
378806002578	catalytic site [active]
378806002579	Helix-turn-helix domain; Region: HTH_17; pfam12728
378806002580	Phage integrase family; Region: Phage_integrase; pfam00589
378806002581	active site
378806002582	DNA binding site [nucleotide binding]
378806002583	Int/Topo IB signature motif; other site
378806002584	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806002585	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806002586	active site
378806002587	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
378806002588	CsbD-like; Region: CsbD; pfam05532
378806002589	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
378806002590	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806002591	Walker A/P-loop; other site
378806002592	ATP binding site [chemical binding]; other site
378806002593	Q-loop/lid; other site
378806002594	ABC transporter signature motif; other site
378806002595	Walker B; other site
378806002596	D-loop; other site
378806002597	H-loop/switch region; other site
378806002598	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806002599	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806002600	dimer interface [polypeptide binding]; other site
378806002601	putative CheW interface [polypeptide binding]; other site
378806002602	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
378806002603	catalytic residues [active]
378806002604	CotH protein; Region: CotH; pfam08757
378806002605	Lamin Tail Domain; Region: LTD; pfam00932
378806002606	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
378806002607	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
378806002608	putative active site [active]
378806002609	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
378806002610	core domain interface [polypeptide binding]; other site
378806002611	delta subunit interface [polypeptide binding]; other site
378806002612	epsilon subunit interface [polypeptide binding]; other site
378806002613	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806002614	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806002615	active site
378806002616	catalytic tetrad [active]
378806002617	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
378806002618	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
378806002619	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
378806002620	alpha subunit interaction interface [polypeptide binding]; other site
378806002621	Walker A motif; other site
378806002622	ATP binding site [chemical binding]; other site
378806002623	Walker B motif; other site
378806002624	inhibitor binding site; inhibition site
378806002625	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
378806002626	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
378806002627	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
378806002628	gamma subunit interface [polypeptide binding]; other site
378806002629	epsilon subunit interface [polypeptide binding]; other site
378806002630	LBP interface [polypeptide binding]; other site
378806002631	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
378806002632	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
378806002633	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
378806002634	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
378806002635	active site
378806002636	dimer interface [polypeptide binding]; other site
378806002637	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
378806002638	dimer interface [polypeptide binding]; other site
378806002639	active site
378806002640	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
378806002641	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
378806002642	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806002643	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806002644	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
378806002645	G1 box; other site
378806002646	GTP/Mg2+ binding site [chemical binding]; other site
378806002647	G2 box; other site
378806002648	Switch I region; other site
378806002649	G3 box; other site
378806002650	Switch II region; other site
378806002651	G4 box; other site
378806002652	G5 box; other site
378806002653	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
378806002654	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
378806002655	AlkA N-terminal domain; Region: AlkA_N; pfam06029
378806002656	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
378806002657	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
378806002658	minor groove reading motif; other site
378806002659	helix-hairpin-helix signature motif; other site
378806002660	substrate binding pocket [chemical binding]; other site
378806002661	active site
378806002662	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
378806002663	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
378806002664	DNA binding site [nucleotide binding]
378806002665	active site
378806002666	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
378806002667	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
378806002668	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806002669	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806002670	DNA binding residues [nucleotide binding]
378806002671	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806002672	S-adenosylmethionine binding site [chemical binding]; other site
378806002673	putative catalytic domain of glycoside hydrolase family 119 (GH119); Region: GH119_BcIgtZ-like; cd11663
378806002674	putative active site [active]
378806002675	catalytic site [active]
378806002676	Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423
378806002677	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806002678	Interdomain contacts; other site
378806002679	Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423
378806002680	Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808
378806002681	starch-binding site 2 [chemical binding]; other site
378806002682	starch-binding site 1 [chemical binding]; other site
378806002683	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806002684	Protein of unknown function, DUF393; Region: DUF393; pfam04134
378806002685	Lipase maturation factor; Region: LMF1; pfam06762
378806002686	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
378806002687	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806002688	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806002689	ligand binding site [chemical binding]; other site
378806002690	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806002691	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806002692	non-specific DNA binding site [nucleotide binding]; other site
378806002693	salt bridge; other site
378806002694	sequence-specific DNA binding site [nucleotide binding]; other site
378806002695	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806002696	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806002697	non-specific DNA binding site [nucleotide binding]; other site
378806002698	salt bridge; other site
378806002699	sequence-specific DNA binding site [nucleotide binding]; other site
378806002700	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806002701	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806002702	non-specific DNA binding site [nucleotide binding]; other site
378806002703	salt bridge; other site
378806002704	sequence-specific DNA binding site [nucleotide binding]; other site
378806002705	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806002706	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806002707	non-specific DNA binding site [nucleotide binding]; other site
378806002708	salt bridge; other site
378806002709	sequence-specific DNA binding site [nucleotide binding]; other site
378806002710	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
378806002711	G1 box; other site
378806002712	GTP/Mg2+ binding site [chemical binding]; other site
378806002713	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
378806002714	catalytic residues [active]
378806002715	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806002716	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806002717	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806002718	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806002719	DNA binding residues [nucleotide binding]
378806002720	dimerization interface [polypeptide binding]; other site
378806002721	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
378806002722	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
378806002723	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
378806002724	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
378806002725	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
378806002726	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806002727	pteridine reductase; Provisional; Region: PRK09135
378806002728	NAD(P) binding site [chemical binding]; other site
378806002729	active site
378806002730	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
378806002731	classical (c) SDRs; Region: SDR_c; cd05233
378806002732	NAD(P) binding site [chemical binding]; other site
378806002733	active site
378806002734	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
378806002735	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
378806002736	active site
378806002737	Right handed beta helix region; Region: Beta_helix; pfam13229
378806002738	Right handed beta helix region; Region: Beta_helix; pfam13229
378806002739	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806002740	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806002741	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806002742	PAS domain; Region: PAS_9; pfam13426
378806002743	putative active site [active]
378806002744	heme pocket [chemical binding]; other site
378806002745	PAS domain S-box; Region: sensory_box; TIGR00229
378806002746	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806002747	putative active site [active]
378806002748	heme pocket [chemical binding]; other site
378806002749	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806002750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002751	dimer interface [polypeptide binding]; other site
378806002752	phosphorylation site [posttranslational modification]
378806002753	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806002754	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806002755	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806002756	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806002757	putative active site [active]
378806002758	heme pocket [chemical binding]; other site
378806002759	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002760	dimer interface [polypeptide binding]; other site
378806002761	phosphorylation site [posttranslational modification]
378806002762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002763	ATP binding site [chemical binding]; other site
378806002764	Mg2+ binding site [ion binding]; other site
378806002765	G-X-G motif; other site
378806002766	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806002767	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
378806002768	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
378806002769	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
378806002770	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
378806002771	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
378806002772	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806002773	motif II; other site
378806002774	MASE1; Region: MASE1; pfam05231
378806002775	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806002776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806002777	putative active site [active]
378806002778	heme pocket [chemical binding]; other site
378806002779	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806002780	dimer interface [polypeptide binding]; other site
378806002781	phosphorylation site [posttranslational modification]
378806002782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002783	ATP binding site [chemical binding]; other site
378806002784	Mg2+ binding site [ion binding]; other site
378806002785	G-X-G motif; other site
378806002786	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806002787	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806002788	active site
378806002789	phosphorylation site [posttranslational modification]
378806002790	intermolecular recognition site; other site
378806002791	dimerization interface [polypeptide binding]; other site
378806002792	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
378806002793	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
378806002794	NAD synthetase; Provisional; Region: PRK13981
378806002795	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
378806002796	multimer interface [polypeptide binding]; other site
378806002797	active site
378806002798	catalytic triad [active]
378806002799	protein interface 1 [polypeptide binding]; other site
378806002800	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
378806002801	homodimer interface [polypeptide binding]; other site
378806002802	NAD binding pocket [chemical binding]; other site
378806002803	ATP binding pocket [chemical binding]; other site
378806002804	Mg binding site [ion binding]; other site
378806002805	active-site loop [active]
378806002806	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
378806002807	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
378806002808	Domain of unknown function DUF21; Region: DUF21; pfam01595
378806002809	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
378806002810	Transporter associated domain; Region: CorC_HlyC; smart01091
378806002811	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
378806002812	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
378806002813	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806002814	catalytic residues [active]
378806002815	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
378806002816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806002817	motif II; other site
378806002818	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
378806002819	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
378806002820	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806002821	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806002822	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
378806002823	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
378806002824	NAD(P) binding site [chemical binding]; other site
378806002825	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806002826	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806002827	active site
378806002828	ATP binding site [chemical binding]; other site
378806002829	substrate binding site [chemical binding]; other site
378806002830	activation loop (A-loop); other site
378806002831	AAA ATPase domain; Region: AAA_16; pfam13191
378806002832	Predicted ATPase [General function prediction only]; Region: COG3899
378806002833	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806002834	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806002835	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806002836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806002837	ATP binding site [chemical binding]; other site
378806002838	Mg2+ binding site [ion binding]; other site
378806002839	G-X-G motif; other site
378806002840	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
378806002841	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
378806002842	TAP-like protein; Region: Abhydrolase_4; pfam08386
378806002843	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
378806002844	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
378806002845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806002846	Walker A/P-loop; other site
378806002847	ATP binding site [chemical binding]; other site
378806002848	Q-loop/lid; other site
378806002849	ABC transporter signature motif; other site
378806002850	Walker B; other site
378806002851	D-loop; other site
378806002852	H-loop/switch region; other site
378806002853	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
378806002854	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
378806002855	Protein of unknown function (DUF2378); Region: DUF2378; cl15288
378806002856	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
378806002857	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
378806002858	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806002859	active site
378806002860	ATP binding site [chemical binding]; other site
378806002861	substrate binding site [chemical binding]; other site
378806002862	activation loop (A-loop); other site
378806002863	Uncharacterized conserved protein [Function unknown]; Region: COG3791
378806002864	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
378806002865	active site
378806002866	homotetramer interface [polypeptide binding]; other site
378806002867	putative OHCU decarboxylase; Provisional; Region: PRK13798
378806002868	allantoicase; Provisional; Region: PRK13257
378806002869	Allantoicase repeat; Region: Allantoicase; pfam03561
378806002870	Allantoicase repeat; Region: Allantoicase; pfam03561
378806002871	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
378806002872	allantoinase; Region: allantoinase; TIGR03178
378806002873	active site
378806002874	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
378806002875	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
378806002876	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806002877	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
378806002878	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
378806002879	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
378806002880	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806002881	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
378806002882	active site
378806002883	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
378806002884	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806002885	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
378806002886	ADP-ribose binding site [chemical binding]; other site
378806002887	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
378806002888	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
378806002889	TPR repeat; Region: TPR_11; pfam13414
378806002890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806002891	TPR motif; other site
378806002892	binding surface
378806002893	Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481
378806002894	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806002895	catalytic tetrad [active]
378806002896	Protein kinase domain; Region: Pkinase; pfam00069
378806002897	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806002898	active site
378806002899	ATP binding site [chemical binding]; other site
378806002900	substrate binding site [chemical binding]; other site
378806002901	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806002902	substrate binding site [chemical binding]; other site
378806002903	activation loop (A-loop); other site
378806002904	activation loop (A-loop); other site
378806002905	TPR repeat; Region: TPR_11; pfam13414
378806002906	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806002907	binding surface
378806002908	TPR motif; other site
378806002909	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
378806002910	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
378806002911	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
378806002912	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
378806002913	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
378806002914	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
378806002915	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
378806002916	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
378806002917	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
378806002918	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
378806002919	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
378806002920	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
378806002921	heme binding site [chemical binding]; other site
378806002922	ferroxidase pore; other site
378806002923	ferroxidase diiron center [ion binding]; other site
378806002924	Glyco_18 domain; Region: Glyco_18; smart00636
378806002925	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
378806002926	active site
378806002927	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
378806002928	aromatic chitin/cellulose binding site residues [chemical binding]; other site
378806002929	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806002930	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806002931	active site
378806002932	ATP binding site [chemical binding]; other site
378806002933	substrate binding site [chemical binding]; other site
378806002934	activation loop (A-loop); other site
378806002935	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
378806002936	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
378806002937	YceI-like domain; Region: YceI; smart00867
378806002938	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806002939	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806002940	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
378806002941	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
378806002942	Zn binding site [ion binding]; other site
378806002943	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
378806002944	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806002945	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806002946	active site
378806002947	metal binding site [ion binding]; metal-binding site
378806002948	Cytochrome c [Energy production and conversion]; Region: COG3258
378806002949	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
378806002950	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
378806002951	cleavage site
378806002952	active site
378806002953	substrate binding sites [chemical binding]; other site
378806002954	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
378806002955	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806002956	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
378806002957	FtsX-like permease family; Region: FtsX; pfam02687
378806002958	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806002959	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
378806002960	FtsX-like permease family; Region: FtsX; pfam02687
378806002961	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
378806002962	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
378806002963	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
378806002964	NAD(P) binding site [chemical binding]; other site
378806002965	catalytic residues [active]
378806002966	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
378806002967	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
378806002968	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806002969	catalytic residue [active]
378806002970	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
378806002971	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
378806002972	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
378806002973	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
378806002974	exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178
378806002975	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
378806002976	metal ion-dependent adhesion site (MIDAS); other site
378806002977	rod shape-determining protein MreB; Provisional; Region: PRK13927
378806002978	MreB and similar proteins; Region: MreB_like; cd10225
378806002979	nucleotide binding site [chemical binding]; other site
378806002980	Mg binding site [ion binding]; other site
378806002981	putative protofilament interaction site [polypeptide binding]; other site
378806002982	RodZ interaction site [polypeptide binding]; other site
378806002983	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
378806002984	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
378806002985	Ligand binding site; other site
378806002986	Putative Catalytic site; other site
378806002987	DXD motif; other site
378806002988	tyrosine decarboxylase; Region: PLN02880
378806002989	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806002990	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806002991	catalytic residue [active]
378806002992	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
378806002993	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
378806002994	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
378806002995	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
378806002996	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
378806002997	active site
378806002998	substrate binding site [chemical binding]; other site
378806002999	trimer interface [polypeptide binding]; other site
378806003000	CoA binding site [chemical binding]; other site
378806003001	Putative zinc-finger; Region: zf-HC2; pfam13490
378806003002	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
378806003003	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
378806003004	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
378806003005	metal binding site [ion binding]; metal-binding site
378806003006	putative dimer interface [polypeptide binding]; other site
378806003007	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
378806003008	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
378806003009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806003010	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
378806003011	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806003012	Predicted integral membrane protein [Function unknown]; Region: COG0392
378806003013	Uncharacterized conserved protein [Function unknown]; Region: COG2898
378806003014	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
378806003015	Response regulator receiver domain; Region: Response_reg; pfam00072
378806003016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806003017	active site
378806003018	phosphorylation site [posttranslational modification]
378806003019	intermolecular recognition site; other site
378806003020	dimerization interface [polypeptide binding]; other site
378806003021	Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687
378806003022	substrate binding pocket [chemical binding]; other site
378806003023	substrate-Mg2+ binding site; other site
378806003024	aspartate-rich region 1; other site
378806003025	active site lid residues [active]
378806003026	aspartate-rich region 2; other site
378806003027	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
378806003028	substrate binding pocket [chemical binding]; other site
378806003029	substrate-Mg2+ binding site; other site
378806003030	aspartate-rich region 1; other site
378806003031	aspartate-rich region 2; other site
378806003032	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806003033	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806003034	ligand binding site [chemical binding]; other site
378806003035	flexible hinge region; other site
378806003036	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806003037	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806003038	ligand binding site [chemical binding]; other site
378806003039	flexible hinge region; other site
378806003040	BNR repeat-like domain; Region: BNR_2; pfam13088
378806003041	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
378806003042	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806003043	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
378806003044	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806003045	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806003046	DNA binding residues [nucleotide binding]
378806003047	dimerization interface [polypeptide binding]; other site
378806003048	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
378806003049	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
378806003050	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
378806003051	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
378806003052	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
378806003053	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806003054	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806003055	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806003056	active site
378806003057	ATP binding site [chemical binding]; other site
378806003058	substrate binding site [chemical binding]; other site
378806003059	activation loop (A-loop); other site
378806003060	Deoxyhypusine synthase; Region: DS; cl00826
378806003061	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
378806003062	aromatic arch; other site
378806003063	DCoH dimer interaction site [polypeptide binding]; other site
378806003064	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
378806003065	DCoH tetramer interaction site [polypeptide binding]; other site
378806003066	substrate binding site [chemical binding]; other site
378806003067	glycerol kinase; Provisional; Region: glpK; PRK00047
378806003068	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
378806003069	N- and C-terminal domain interface [polypeptide binding]; other site
378806003070	active site
378806003071	MgATP binding site [chemical binding]; other site
378806003072	catalytic site [active]
378806003073	metal binding site [ion binding]; metal-binding site
378806003074	glycerol binding site [chemical binding]; other site
378806003075	homotetramer interface [polypeptide binding]; other site
378806003076	homodimer interface [polypeptide binding]; other site
378806003077	FBP binding site [chemical binding]; other site
378806003078	protein IIAGlc interface [polypeptide binding]; other site
378806003079	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806003080	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806003081	phosphopeptide binding site; other site
378806003082	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
378806003083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806003084	putative substrate translocation pore; other site
378806003085	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806003086	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806003087	non-specific DNA binding site [nucleotide binding]; other site
378806003088	salt bridge; other site
378806003089	sequence-specific DNA binding site [nucleotide binding]; other site
378806003090	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
378806003091	active site
378806003092	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
378806003093	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
378806003094	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
378806003095	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
378806003096	Ligand Binding Site [chemical binding]; other site
378806003097	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
378806003098	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806003099	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806003100	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
378806003101	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
378806003102	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
378806003103	Walker A/P-loop; other site
378806003104	ATP binding site [chemical binding]; other site
378806003105	Q-loop/lid; other site
378806003106	ABC transporter signature motif; other site
378806003107	Walker B; other site
378806003108	D-loop; other site
378806003109	H-loop/switch region; other site
378806003110	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806003111	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806003112	active site
378806003113	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806003114	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806003115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806003116	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
378806003117	Enoylreductase; Region: PKS_ER; smart00829
378806003118	NAD(P) binding site [chemical binding]; other site
378806003119	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806003120	KR domain; Region: KR; pfam08659
378806003121	putative NADP binding site [chemical binding]; other site
378806003122	active site
378806003123	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806003124	Condensation domain; Region: Condensation; pfam00668
378806003125	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806003126	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806003127	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806003128	acyl-activating enzyme (AAE) consensus motif; other site
378806003129	AMP binding site [chemical binding]; other site
378806003130	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806003131	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806003132	S-adenosylmethionine binding site [chemical binding]; other site
378806003133	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806003134	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806003135	Condensation domain; Region: Condensation; pfam00668
378806003136	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806003137	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806003138	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806003139	acyl-activating enzyme (AAE) consensus motif; other site
378806003140	AMP binding site [chemical binding]; other site
378806003141	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806003142	Condensation domain; Region: Condensation; pfam00668
378806003143	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806003144	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
378806003145	Condensation domain; Region: Condensation; pfam00668
378806003146	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806003147	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806003148	acyl-activating enzyme (AAE) consensus motif; other site
378806003149	AMP binding site [chemical binding]; other site
378806003150	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806003151	Condensation domain; Region: Condensation; pfam00668
378806003152	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806003153	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806003154	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806003155	acyl-activating enzyme (AAE) consensus motif; other site
378806003156	AMP binding site [chemical binding]; other site
378806003157	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806003158	Condensation domain; Region: Condensation; pfam00668
378806003159	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806003160	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806003161	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806003162	acyl-activating enzyme (AAE) consensus motif; other site
378806003163	AMP binding site [chemical binding]; other site
378806003164	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806003165	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
378806003166	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806003167	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806003168	acyl-activating enzyme (AAE) consensus motif; other site
378806003169	AMP binding site [chemical binding]; other site
378806003170	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806003171	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
378806003172	Esterase/lipase [General function prediction only]; Region: COG1647
378806003173	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
378806003174	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
378806003175	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
378806003176	cell division protein ZipA; Provisional; Region: PRK03427
378806003177	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
378806003178	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806003179	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806003180	DNA binding residues [nucleotide binding]
378806003181	Putative zinc-finger; Region: zf-HC2; pfam13490
378806003182	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
378806003183	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
378806003184	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
378806003185	putative active site [active]
378806003186	putative active site [active]
378806003187	catalytic site [active]
378806003188	catalytic site [active]
378806003189	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
378806003190	putative active site [active]
378806003191	catalytic site [active]
378806003192	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
378806003193	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806003194	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
378806003195	putative C-terminal domain interface [polypeptide binding]; other site
378806003196	putative GSH binding site (G-site) [chemical binding]; other site
378806003197	putative dimer interface [polypeptide binding]; other site
378806003198	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
378806003199	N-terminal domain interface [polypeptide binding]; other site
378806003200	dimer interface [polypeptide binding]; other site
378806003201	substrate binding pocket (H-site) [chemical binding]; other site
378806003202	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
378806003203	TrkA-N domain; Region: TrkA_N; pfam02254
378806003204	TrkA-C domain; Region: TrkA_C; pfam02080
378806003205	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806003206	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806003207	ligand binding site [chemical binding]; other site
378806003208	flexible hinge region; other site
378806003209	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
378806003210	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806003211	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806003212	calcium binding site 2 [ion binding]; other site
378806003213	active site
378806003214	catalytic triad [active]
378806003215	calcium binding site 1 [ion binding]; other site
378806003216	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806003217	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
378806003218	intracellular protease, PfpI family; Region: PfpI; TIGR01382
378806003219	proposed catalytic triad [active]
378806003220	conserved cys residue [active]
378806003221	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
378806003222	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003223	dimerization interface [polypeptide binding]; other site
378806003224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003225	dimer interface [polypeptide binding]; other site
378806003226	phosphorylation site [posttranslational modification]
378806003227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003228	ATP binding site [chemical binding]; other site
378806003229	Mg2+ binding site [ion binding]; other site
378806003230	G-X-G motif; other site
378806003231	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806003232	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003233	dimerization interface [polypeptide binding]; other site
378806003234	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003235	dimerization interface [polypeptide binding]; other site
378806003236	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003237	dimerization interface [polypeptide binding]; other site
378806003238	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003239	dimerization interface [polypeptide binding]; other site
378806003240	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003241	dimerization interface [polypeptide binding]; other site
378806003242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003243	dimerization interface [polypeptide binding]; other site
378806003244	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003245	dimerization interface [polypeptide binding]; other site
378806003246	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806003247	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003248	dimerization interface [polypeptide binding]; other site
378806003249	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003250	dimerization interface [polypeptide binding]; other site
378806003251	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806003252	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003253	dimerization interface [polypeptide binding]; other site
378806003254	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003255	dimerization interface [polypeptide binding]; other site
378806003256	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003257	dimerization interface [polypeptide binding]; other site
378806003258	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003259	dimerization interface [polypeptide binding]; other site
378806003260	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806003261	dimerization interface [polypeptide binding]; other site
378806003262	GAF domain; Region: GAF_2; pfam13185
378806003263	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003264	dimer interface [polypeptide binding]; other site
378806003265	phosphorylation site [posttranslational modification]
378806003266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003267	ATP binding site [chemical binding]; other site
378806003268	Mg2+ binding site [ion binding]; other site
378806003269	G-X-G motif; other site
378806003270	Response regulator receiver domain; Region: Response_reg; pfam00072
378806003271	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806003272	active site
378806003273	phosphorylation site [posttranslational modification]
378806003274	intermolecular recognition site; other site
378806003275	dimerization interface [polypeptide binding]; other site
378806003276	Response regulator receiver domain; Region: Response_reg; pfam00072
378806003277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806003278	active site
378806003279	phosphorylation site [posttranslational modification]
378806003280	intermolecular recognition site; other site
378806003281	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806003282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806003283	active site
378806003284	phosphorylation site [posttranslational modification]
378806003285	intermolecular recognition site; other site
378806003286	dimerization interface [polypeptide binding]; other site
378806003287	Response regulator receiver domain; Region: Response_reg; pfam00072
378806003288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806003289	active site
378806003290	phosphorylation site [posttranslational modification]
378806003291	intermolecular recognition site; other site
378806003292	dimerization interface [polypeptide binding]; other site
378806003293	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806003294	PAS fold; Region: PAS_3; pfam08447
378806003295	putative active site [active]
378806003296	heme pocket [chemical binding]; other site
378806003297	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806003298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806003299	putative active site [active]
378806003300	heme pocket [chemical binding]; other site
378806003301	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003302	dimer interface [polypeptide binding]; other site
378806003303	phosphorylation site [posttranslational modification]
378806003304	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003305	ATP binding site [chemical binding]; other site
378806003306	Mg2+ binding site [ion binding]; other site
378806003307	G-X-G motif; other site
378806003308	GAF domain; Region: GAF_3; pfam13492
378806003309	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806003310	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806003311	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003312	dimer interface [polypeptide binding]; other site
378806003313	phosphorylation site [posttranslational modification]
378806003314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003315	ATP binding site [chemical binding]; other site
378806003316	Mg2+ binding site [ion binding]; other site
378806003317	G-X-G motif; other site
378806003318	Response regulator receiver domain; Region: Response_reg; pfam00072
378806003319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806003320	active site
378806003321	phosphorylation site [posttranslational modification]
378806003322	intermolecular recognition site; other site
378806003323	dimerization interface [polypeptide binding]; other site
378806003324	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806003325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003326	dimer interface [polypeptide binding]; other site
378806003327	phosphorylation site [posttranslational modification]
378806003328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003329	ATP binding site [chemical binding]; other site
378806003330	Mg2+ binding site [ion binding]; other site
378806003331	G-X-G motif; other site
378806003332	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
378806003333	EamA-like transporter family; Region: EamA; pfam00892
378806003334	EamA-like transporter family; Region: EamA; pfam00892
378806003335	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
378806003336	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
378806003337	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
378806003338	active site
378806003339	catalytic residues [active]
378806003340	putative lipid kinase; Reviewed; Region: PRK13057
378806003341	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
378806003342	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806003343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806003344	NAD(P) binding site [chemical binding]; other site
378806003345	active site
378806003346	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
378806003347	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806003348	motif II; other site
378806003349	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
378806003350	active site
378806003351	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
378806003352	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
378806003353	putative substrate binding region [chemical binding]; other site
378806003354	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806003355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003356	phosphorylation site [posttranslational modification]
378806003357	dimer interface [polypeptide binding]; other site
378806003358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003359	ATP binding site [chemical binding]; other site
378806003360	Mg2+ binding site [ion binding]; other site
378806003361	G-X-G motif; other site
378806003362	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
378806003363	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806003364	active site
378806003365	phosphorylation site [posttranslational modification]
378806003366	intermolecular recognition site; other site
378806003367	dimerization interface [polypeptide binding]; other site
378806003368	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806003369	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
378806003370	DEAD/DEAH box helicase; Region: DEAD; pfam00270
378806003371	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
378806003372	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
378806003373	Ycf48-like protein; Provisional; Region: PRK13684
378806003374	Fusaric acid resistance protein family; Region: FUSC; pfam04632
378806003375	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
378806003376	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
378806003377	N-terminal plug; other site
378806003378	ligand-binding site [chemical binding]; other site
378806003379	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
378806003380	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806003381	inhibitor-cofactor binding pocket; inhibition site
378806003382	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806003383	catalytic residue [active]
378806003384	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806003385	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806003386	DNA-binding site [nucleotide binding]; DNA binding site
378806003387	Protein kinase domain; Region: Pkinase; pfam00069
378806003388	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806003389	active site
378806003390	ATP binding site [chemical binding]; other site
378806003391	substrate binding site [chemical binding]; other site
378806003392	activation loop (A-loop); other site
378806003393	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
378806003394	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806003395	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806003396	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
378806003397	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806003398	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806003399	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
378806003400	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806003401	catalytic residues [active]
378806003402	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
378806003403	Penicillinase repressor; Region: Pencillinase_R; pfam03965
378806003404	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
378806003405	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
378806003406	Helix-turn-helix domain; Region: HTH_17; pfam12728
378806003407	PBP superfamily domain; Region: PBP_like; pfam12727
378806003408	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
378806003409	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
378806003410	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806003411	Walker A motif; other site
378806003412	ATP binding site [chemical binding]; other site
378806003413	Walker B motif; other site
378806003414	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
378806003415	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806003416	Walker A motif; other site
378806003417	ATP binding site [chemical binding]; other site
378806003418	Walker B motif; other site
378806003419	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806003420	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
378806003421	Coenzyme A binding pocket [chemical binding]; other site
378806003422	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
378806003423	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
378806003424	G1 box; other site
378806003425	GTP/Mg2+ binding site [chemical binding]; other site
378806003426	G2 box; other site
378806003427	Switch I region; other site
378806003428	G3 box; other site
378806003429	Switch II region; other site
378806003430	G4 box; other site
378806003431	Sensory domain found in PocR; Region: PocR; pfam10114
378806003432	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806003433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003434	dimer interface [polypeptide binding]; other site
378806003435	phosphorylation site [posttranslational modification]
378806003436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003437	ATP binding site [chemical binding]; other site
378806003438	Mg2+ binding site [ion binding]; other site
378806003439	G-X-G motif; other site
378806003440	thiamine monophosphate kinase; Provisional; Region: PRK05731
378806003441	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
378806003442	ATP binding site [chemical binding]; other site
378806003443	dimerization interface [polypeptide binding]; other site
378806003444	HAMP domain; Region: HAMP; pfam00672
378806003445	dimerization interface [polypeptide binding]; other site
378806003446	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806003447	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806003448	dimer interface [polypeptide binding]; other site
378806003449	putative CheW interface [polypeptide binding]; other site
378806003450	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
378806003451	Response regulator receiver domain; Region: Response_reg; pfam00072
378806003452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806003453	active site
378806003454	phosphorylation site [posttranslational modification]
378806003455	intermolecular recognition site; other site
378806003456	dimerization interface [polypeptide binding]; other site
378806003457	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806003458	putative binding surface; other site
378806003459	active site
378806003460	P2 response regulator binding domain; Region: P2; pfam07194
378806003461	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
378806003462	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
378806003463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003464	ATP binding site [chemical binding]; other site
378806003465	Mg2+ binding site [ion binding]; other site
378806003466	G-X-G motif; other site
378806003467	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806003468	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
378806003469	CheC-like family; Region: CheC; pfam04509
378806003470	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
378806003471	AIR carboxylase; Region: AIRC; smart01001
378806003472	Protein of unknown function DUF111; Region: DUF111; pfam01969
378806003473	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
378806003474	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806003475	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806003476	putative catalytic site [active]
378806003477	putative metal binding site [ion binding]; other site
378806003478	putative phosphate binding site [ion binding]; other site
378806003479	GrpE; Region: GrpE; pfam01025
378806003480	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
378806003481	dimer interface [polypeptide binding]; other site
378806003482	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
378806003483	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
378806003484	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
378806003485	nucleotide binding site [chemical binding]; other site
378806003486	NEF interaction site [polypeptide binding]; other site
378806003487	SBD interface [polypeptide binding]; other site
378806003488	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806003489	Protein kinase domain; Region: Pkinase; pfam00069
378806003490	active site
378806003491	ATP binding site [chemical binding]; other site
378806003492	substrate binding site [chemical binding]; other site
378806003493	activation loop (A-loop); other site
378806003494	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806003495	metabolite-proton symporter; Region: 2A0106; TIGR00883
378806003496	putative substrate translocation pore; other site
378806003497	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
378806003498	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
378806003499	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
378806003500	putative ligand binding site [chemical binding]; other site
378806003501	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806003502	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
378806003503	TM-ABC transporter signature motif; other site
378806003504	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
378806003505	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
378806003506	TM-ABC transporter signature motif; other site
378806003507	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
378806003508	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
378806003509	Walker A/P-loop; other site
378806003510	ATP binding site [chemical binding]; other site
378806003511	Q-loop/lid; other site
378806003512	ABC transporter signature motif; other site
378806003513	Walker B; other site
378806003514	D-loop; other site
378806003515	H-loop/switch region; other site
378806003516	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
378806003517	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
378806003518	Walker A/P-loop; other site
378806003519	ATP binding site [chemical binding]; other site
378806003520	Q-loop/lid; other site
378806003521	ABC transporter signature motif; other site
378806003522	Walker B; other site
378806003523	D-loop; other site
378806003524	H-loop/switch region; other site
378806003525	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806003526	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806003527	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806003528	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
378806003529	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
378806003530	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
378806003531	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
378806003532	cyclase homology domain; Region: CHD; cd07302
378806003533	nucleotidyl binding site; other site
378806003534	metal binding site [ion binding]; metal-binding site
378806003535	dimer interface [polypeptide binding]; other site
378806003536	prolyl-tRNA synthetase; Provisional; Region: PRK08661
378806003537	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
378806003538	dimer interface [polypeptide binding]; other site
378806003539	motif 1; other site
378806003540	active site
378806003541	motif 2; other site
378806003542	motif 3; other site
378806003543	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
378806003544	anticodon binding site; other site
378806003545	zinc-binding site [ion binding]; other site
378806003546	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
378806003547	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
378806003548	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
378806003549	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
378806003550	Uncharacterized conserved protein [Function unknown]; Region: COG1434
378806003551	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
378806003552	putative active site [active]
378806003553	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
378806003554	MarR family; Region: MarR; pfam01047
378806003555	MarR family; Region: MarR_2; cl17246
378806003556	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
378806003557	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
378806003558	malonyl-CoA binding site [chemical binding]; other site
378806003559	dimer interface [polypeptide binding]; other site
378806003560	active site
378806003561	product binding site; other site
378806003562	Phospholipid methyltransferase; Region: PEMT; cl17370
378806003563	acyl-CoA synthetase; Validated; Region: PRK09192
378806003564	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806003565	acyl-activating enzyme (AAE) consensus motif; other site
378806003566	active site
378806003567	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806003568	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
378806003569	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
378806003570	Uncharacterized conserved protein [Function unknown]; Region: COG3410
378806003571	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806003572	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806003573	DNA-binding site [nucleotide binding]; DNA binding site
378806003574	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806003575	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
378806003576	short chain dehydrogenase; Provisional; Region: PRK07102
378806003577	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
378806003578	NAD(P) binding site [chemical binding]; other site
378806003579	active site
378806003580	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
378806003581	FAD binding domain; Region: FAD_binding_4; pfam01565
378806003582	hypothetical protein; Validated; Region: PRK08238
378806003583	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
378806003584	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
378806003585	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806003586	putative DNA binding site [nucleotide binding]; other site
378806003587	putative Zn2+ binding site [ion binding]; other site
378806003588	O-methyltransferase; Region: Methyltransf_2; pfam00891
378806003589	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806003590	Predicted membrane protein (DUF2069); Region: DUF2069; cl01299
378806003591	Response regulator receiver domain; Region: Response_reg; pfam00072
378806003592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806003593	active site
378806003594	phosphorylation site [posttranslational modification]
378806003595	intermolecular recognition site; other site
378806003596	dimerization interface [polypeptide binding]; other site
378806003597	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806003598	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
378806003599	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
378806003600	catalytic triad [active]
378806003601	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806003602	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806003603	active site
378806003604	ATP binding site [chemical binding]; other site
378806003605	substrate binding site [chemical binding]; other site
378806003606	activation loop (A-loop); other site
378806003607	AAA ATPase domain; Region: AAA_16; pfam13191
378806003608	Predicted ATPase [General function prediction only]; Region: COG3899
378806003609	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806003610	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806003611	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003612	dimer interface [polypeptide binding]; other site
378806003613	phosphorylation site [posttranslational modification]
378806003614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003615	ATP binding site [chemical binding]; other site
378806003616	Mg2+ binding site [ion binding]; other site
378806003617	G-X-G motif; other site
378806003618	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806003619	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806003620	ligand binding site [chemical binding]; other site
378806003621	flexible hinge region; other site
378806003622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003623	ATP binding site [chemical binding]; other site
378806003624	Mg2+ binding site [ion binding]; other site
378806003625	G-X-G motif; other site
378806003626	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
378806003627	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
378806003628	TPR repeat; Region: TPR_11; pfam13414
378806003629	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806003630	binding surface
378806003631	TPR motif; other site
378806003632	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806003633	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806003634	ligand binding site [chemical binding]; other site
378806003635	flexible hinge region; other site
378806003636	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806003637	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806003638	ligand binding site [chemical binding]; other site
378806003639	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806003640	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806003641	ligand binding site [chemical binding]; other site
378806003642	flexible hinge region; other site
378806003643	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
378806003644	putative switch regulator; other site
378806003645	non-specific DNA interactions [nucleotide binding]; other site
378806003646	DNA binding site [nucleotide binding]
378806003647	sequence specific DNA binding site [nucleotide binding]; other site
378806003648	putative cAMP binding site [chemical binding]; other site
378806003649	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
378806003650	ATP binding site [chemical binding]; other site
378806003651	PAS domain; Region: PAS_9; pfam13426
378806003652	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
378806003653	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806003654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806003655	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003656	dimer interface [polypeptide binding]; other site
378806003657	phosphorylation site [posttranslational modification]
378806003658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003659	ATP binding site [chemical binding]; other site
378806003660	Mg2+ binding site [ion binding]; other site
378806003661	G-X-G motif; other site
378806003662	N-terminal double-transmembrane domain; Region: two_anch; TIGR02226
378806003663	von Willebrand factor type A domain; Region: VWA_2; pfam13519
378806003664	metal ion-dependent adhesion site (MIDAS); other site
378806003665	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
378806003666	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
378806003667	Protein of unknown function DUF58; Region: DUF58; pfam01882
378806003668	von Willebrand factor type A domain; Region: VWA_2; pfam13519
378806003669	MoxR-like ATPases [General function prediction only]; Region: COG0714
378806003670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806003671	Walker A motif; other site
378806003672	ATP binding site [chemical binding]; other site
378806003673	Walker B motif; other site
378806003674	arginine finger; other site
378806003675	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
378806003676	Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266
378806003677	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
378806003678	nucleotide binding site [chemical binding]; other site
378806003679	putative NEF/HSP70 interaction site [polypeptide binding]; other site
378806003680	SBD interface [polypeptide binding]; other site
378806003681	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
378806003682	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806003683	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
378806003684	active site
378806003685	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
378806003686	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806003687	trehalose synthase; Region: treS_nterm; TIGR02456
378806003688	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
378806003689	Ca binding site [ion binding]; other site
378806003690	active site
378806003691	catalytic site [active]
378806003692	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
378806003693	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
378806003694	active site
378806003695	Zn binding site [ion binding]; other site
378806003696	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
378806003697	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
378806003698	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
378806003699	putative active site [active]
378806003700	metal binding site [ion binding]; metal-binding site
378806003701	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806003702	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806003703	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806003704	metal binding site [ion binding]; metal-binding site
378806003705	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
378806003706	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
378806003707	cofactor binding site; other site
378806003708	metal binding site [ion binding]; metal-binding site
378806003709	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806003710	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806003711	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
378806003712	dimerization interface [polypeptide binding]; other site
378806003713	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
378806003714	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
378806003715	substrate binding pocket [chemical binding]; other site
378806003716	membrane-bound complex binding site; other site
378806003717	hinge residues; other site
378806003718	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
378806003719	Cation efflux family; Region: Cation_efflux; pfam01545
378806003720	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
378806003721	intersubunit interface [polypeptide binding]; other site
378806003722	active site
378806003723	Zn2+ binding site [ion binding]; other site
378806003724	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
378806003725	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
378806003726	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
378806003727	muropeptide transporter; Validated; Region: ampG; cl17669
378806003728	muropeptide transporter; Reviewed; Region: ampG; PRK11902
378806003729	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
378806003730	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
378806003731	Walker A/P-loop; other site
378806003732	ATP binding site [chemical binding]; other site
378806003733	Q-loop/lid; other site
378806003734	ABC transporter signature motif; other site
378806003735	Walker B; other site
378806003736	D-loop; other site
378806003737	H-loop/switch region; other site
378806003738	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
378806003739	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
378806003740	Walker A/P-loop; other site
378806003741	ATP binding site [chemical binding]; other site
378806003742	Q-loop/lid; other site
378806003743	ABC transporter signature motif; other site
378806003744	Walker B; other site
378806003745	D-loop; other site
378806003746	H-loop/switch region; other site
378806003747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806003748	dimer interface [polypeptide binding]; other site
378806003749	conserved gate region; other site
378806003750	putative PBP binding loops; other site
378806003751	ABC-ATPase subunit interface; other site
378806003752	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
378806003753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806003754	dimer interface [polypeptide binding]; other site
378806003755	conserved gate region; other site
378806003756	putative PBP binding loops; other site
378806003757	ABC-ATPase subunit interface; other site
378806003758	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
378806003759	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
378806003760	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
378806003761	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806003762	active site
378806003763	DNA binding site [nucleotide binding]
378806003764	Int/Topo IB signature motif; other site
378806003765	Helix-turn-helix domain; Region: HTH_17; pfam12728
378806003766	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806003767	Protein kinase domain; Region: Pkinase; pfam00069
378806003768	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806003769	active site
378806003770	ATP binding site [chemical binding]; other site
378806003771	substrate binding site [chemical binding]; other site
378806003772	activation loop (A-loop); other site
378806003773	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806003774	active site
378806003775	ATP binding site [chemical binding]; other site
378806003776	substrate binding site [chemical binding]; other site
378806003777	activation loop (A-loop); other site
378806003778	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806003779	non-specific DNA binding site [nucleotide binding]; other site
378806003780	salt bridge; other site
378806003781	sequence-specific DNA binding site [nucleotide binding]; other site
378806003782	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806003783	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806003784	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806003785	DNA binding residues [nucleotide binding]
378806003786	Methyltransferase domain; Region: Methyltransf_32; pfam13679
378806003787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806003788	TPR motif; other site
378806003789	TPR repeat; Region: TPR_11; pfam13414
378806003790	binding surface
378806003791	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806003792	dimerization interface [polypeptide binding]; other site
378806003793	putative DNA binding site [nucleotide binding]; other site
378806003794	putative Zn2+ binding site [ion binding]; other site
378806003795	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
378806003796	putative hydrophobic ligand binding site [chemical binding]; other site
378806003797	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806003798	putative catalytic site [active]
378806003799	putative metal binding site [ion binding]; other site
378806003800	putative phosphate binding site [ion binding]; other site
378806003801	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806003802	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
378806003803	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
378806003804	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806003805	benzoate transport; Region: 2A0115; TIGR00895
378806003806	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806003807	putative substrate translocation pore; other site
378806003808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806003809	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
378806003810	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
378806003811	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
378806003812	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
378806003813	tetramer interface [polypeptide binding]; other site
378806003814	active site
378806003815	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
378806003816	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
378806003817	heterodimer interface [polypeptide binding]; other site
378806003818	active site
378806003819	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
378806003820	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
378806003821	active site
378806003822	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
378806003823	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
378806003824	dimer interface [polypeptide binding]; other site
378806003825	active site
378806003826	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
378806003827	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
378806003828	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
378806003829	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
378806003830	Bacterial transcriptional regulator; Region: IclR; pfam01614
378806003831	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
378806003832	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
378806003833	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
378806003834	active site
378806003835	FMN binding site [chemical binding]; other site
378806003836	substrate binding site [chemical binding]; other site
378806003837	homotetramer interface [polypeptide binding]; other site
378806003838	catalytic residue [active]
378806003839	Domain of unknown function DUF11; Region: DUF11; cl17728
378806003840	Domain of unknown function DUF11; Region: DUF11; pfam01345
378806003841	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806003842	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
378806003843	Right handed beta helix region; Region: Beta_helix; pfam13229
378806003844	Predicted membrane protein [Function unknown]; Region: COG2259
378806003845	potential frameshift: common BLAST hit: gi|186685728|ref|YP_001868924.1| multi-sensor hybrid multi-kinase
378806003846	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806003847	substrate binding site [chemical binding]; other site
378806003848	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806003849	activation loop (A-loop); other site
378806003850	AAA ATPase domain; Region: AAA_16; pfam13191
378806003851	Predicted ATPase [General function prediction only]; Region: COG3899
378806003852	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806003853	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806003854	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806003855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003856	ATP binding site [chemical binding]; other site
378806003857	Mg2+ binding site [ion binding]; other site
378806003858	G-X-G motif; other site
378806003859	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806003860	Uncharacterized conserved protein [Function unknown]; Region: COG2966
378806003861	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
378806003862	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
378806003863	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
378806003864	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
378806003865	putative catalytic residue [active]
378806003866	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806003867	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806003868	active site
378806003869	catalytic tetrad [active]
378806003870	Glycosyl hydrolase family 43; Region: GH43_4; cd08983
378806003871	active site
378806003872	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806003873	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
378806003874	active site
378806003875	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806003876	YceI-like domain; Region: YceI; pfam04264
378806003877	choice-of-anchor B domain; Region: choice_anch_B; TIGR04312
378806003878	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806003879	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806003880	active site
378806003881	ATP binding site [chemical binding]; other site
378806003882	substrate binding site [chemical binding]; other site
378806003883	activation loop (A-loop); other site
378806003884	Predicted ATPase [General function prediction only]; Region: COG3899
378806003885	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806003886	Walker A motif; other site
378806003887	ATP binding site [chemical binding]; other site
378806003888	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806003889	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806003890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003891	dimer interface [polypeptide binding]; other site
378806003892	phosphorylation site [posttranslational modification]
378806003893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003894	ATP binding site [chemical binding]; other site
378806003895	Mg2+ binding site [ion binding]; other site
378806003896	G-X-G motif; other site
378806003897	putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266
378806003898	YcaO-like family; Region: YcaO; pfam02624
378806003899	Uncharacterized conserved protein [Function unknown]; Region: COG3482
378806003900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
378806003901	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
378806003902	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806003903	catalytic residues [active]
378806003904	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
378806003905	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806003906	4-alpha-glucanotransferase; Provisional; Region: PRK14508
378806003907	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
378806003908	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
378806003909	substrate binding site [chemical binding]; other site
378806003910	ATP binding site [chemical binding]; other site
378806003911	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
378806003912	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
378806003913	nucleotide binding site [chemical binding]; other site
378806003914	glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
378806003915	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
378806003916	active site
378806003917	Substrate binding site; other site
378806003918	Mg++ binding site; other site
378806003919	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
378806003920	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806003921	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806003922	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806003923	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
378806003924	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806003925	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
378806003926	inhibitor-cofactor binding pocket; inhibition site
378806003927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806003928	catalytic residue [active]
378806003929	Cupin domain; Region: Cupin_2; pfam07883
378806003930	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
378806003931	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
378806003932	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
378806003933	Walker A/P-loop; other site
378806003934	ATP binding site [chemical binding]; other site
378806003935	Q-loop/lid; other site
378806003936	ABC transporter signature motif; other site
378806003937	Walker B; other site
378806003938	D-loop; other site
378806003939	H-loop/switch region; other site
378806003940	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
378806003941	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
378806003942	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
378806003943	Walker A/P-loop; other site
378806003944	ATP binding site [chemical binding]; other site
378806003945	Q-loop/lid; other site
378806003946	ABC transporter signature motif; other site
378806003947	Walker B; other site
378806003948	D-loop; other site
378806003949	H-loop/switch region; other site
378806003950	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
378806003951	active site
378806003952	substrate binding site [chemical binding]; other site
378806003953	ATP binding site [chemical binding]; other site
378806003954	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
378806003955	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
378806003956	NAD(P) binding site [chemical binding]; other site
378806003957	LDH/MDH dimer interface [polypeptide binding]; other site
378806003958	substrate binding site [chemical binding]; other site
378806003959	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
378806003960	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
378806003961	active site
378806003962	NAD binding site [chemical binding]; other site
378806003963	metal binding site [ion binding]; metal-binding site
378806003964	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
378806003965	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
378806003966	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
378806003967	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
378806003968	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
378806003969	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
378806003970	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
378806003971	malonic semialdehyde reductase; Provisional; Region: PRK10538
378806003972	putative NAD(P) binding site [chemical binding]; other site
378806003973	homodimer interface [polypeptide binding]; other site
378806003974	homotetramer interface [polypeptide binding]; other site
378806003975	active site
378806003976	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
378806003977	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
378806003978	Surface antigen; Region: Bac_surface_Ag; pfam01103
378806003979	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
378806003980	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
378806003981	Thioredoxin; Region: Thioredoxin_4; pfam13462
378806003982	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
378806003983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806003984	PAS fold; Region: PAS_3; pfam08447
378806003985	putative active site [active]
378806003986	heme pocket [chemical binding]; other site
378806003987	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
378806003988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806003989	putative active site [active]
378806003990	heme pocket [chemical binding]; other site
378806003991	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806003992	putative active site [active]
378806003993	heme pocket [chemical binding]; other site
378806003994	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806003995	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806003996	dimer interface [polypeptide binding]; other site
378806003997	phosphorylation site [posttranslational modification]
378806003998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806003999	ATP binding site [chemical binding]; other site
378806004000	Mg2+ binding site [ion binding]; other site
378806004001	G-X-G motif; other site
378806004002	Response regulator receiver domain; Region: Response_reg; pfam00072
378806004003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806004004	active site
378806004005	phosphorylation site [posttranslational modification]
378806004006	intermolecular recognition site; other site
378806004007	dimerization interface [polypeptide binding]; other site
378806004008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806004009	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806004010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806004011	S-adenosylmethionine binding site [chemical binding]; other site
378806004012	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
378806004013	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
378806004014	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
378806004015	TPR repeat; Region: TPR_11; pfam13414
378806004016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004017	binding surface
378806004018	TPR motif; other site
378806004019	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806004020	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806004021	active site
378806004022	ATP binding site [chemical binding]; other site
378806004023	substrate binding site [chemical binding]; other site
378806004024	activation loop (A-loop); other site
378806004025	AAA ATPase domain; Region: AAA_16; pfam13191
378806004026	ribonuclease R; Region: RNase_R; TIGR02063
378806004027	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
378806004028	RNB domain; Region: RNB; pfam00773
378806004029	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
378806004030	RNA binding site [nucleotide binding]; other site
378806004031	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806004032	sugar binding site [chemical binding]; other site
378806004033	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806004034	active site
378806004035	metal binding site [ion binding]; metal-binding site
378806004036	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806004037	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
378806004038	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
378806004039	XdhC Rossmann domain; Region: XdhC_C; pfam13478
378806004040	6-phosphofructokinase; Provisional; Region: PRK03202
378806004041	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
378806004042	active site
378806004043	ADP/pyrophosphate binding site [chemical binding]; other site
378806004044	dimerization interface [polypeptide binding]; other site
378806004045	allosteric effector site; other site
378806004046	fructose-1,6-bisphosphate binding site; other site
378806004047	Amidase; Region: Amidase; cl11426
378806004048	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
378806004049	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
378806004050	active site
378806004051	trimer interface [polypeptide binding]; other site
378806004052	allosteric site; other site
378806004053	active site lid [active]
378806004054	hexamer (dimer of trimers) interface [polypeptide binding]; other site
378806004055	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
378806004056	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806004057	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806004058	catalytic residue [active]
378806004059	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806004060	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806004061	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
378806004062	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
378806004063	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
378806004064	phage tail protein domain; Region: tail_TIGR02242
378806004065	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
378806004066	FAD binding domain; Region: FAD_binding_4; pfam01565
378806004067	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806004068	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
378806004069	putative acyl-acceptor binding pocket; other site
378806004070	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
378806004071	putative acyl-acceptor binding pocket; other site
378806004072	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
378806004073	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
378806004074	choline-sulfatase; Region: chol_sulfatase; TIGR03417
378806004075	Sulfatase; Region: Sulfatase; cl17466
378806004076	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
378806004077	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
378806004078	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806004079	Walker A/P-loop; other site
378806004080	ATP binding site [chemical binding]; other site
378806004081	Q-loop/lid; other site
378806004082	ABC transporter signature motif; other site
378806004083	Walker B; other site
378806004084	D-loop; other site
378806004085	H-loop/switch region; other site
378806004086	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
378806004087	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
378806004088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806004089	dimer interface [polypeptide binding]; other site
378806004090	conserved gate region; other site
378806004091	ABC-ATPase subunit interface; other site
378806004092	LysR family transcriptional regulator; Provisional; Region: PRK14997
378806004093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806004094	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
378806004095	putative effector binding pocket; other site
378806004096	dimerization interface [polypeptide binding]; other site
378806004097	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806004098	YhhN-like protein; Region: YhhN; pfam07947
378806004099	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004100	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004101	binding surface
378806004102	TPR motif; other site
378806004103	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004104	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004106	binding surface
378806004107	TPR motif; other site
378806004108	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004109	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004110	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004111	binding surface
378806004112	TPR motif; other site
378806004113	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004114	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004116	binding surface
378806004117	TPR motif; other site
378806004118	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004119	CHAT domain; Region: CHAT; pfam12770
378806004120	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
378806004121	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
378806004122	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
378806004123	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
378806004124	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806004125	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806004126	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806004127	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806004128	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
378806004129	dimerization interface [polypeptide binding]; other site
378806004130	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
378806004131	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
378806004132	FMN binding site [chemical binding]; other site
378806004133	substrate binding site [chemical binding]; other site
378806004134	putative catalytic residue [active]
378806004135	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
378806004136	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
378806004137	ligand binding site [chemical binding]; other site
378806004138	NAD binding site [chemical binding]; other site
378806004139	tetramer interface [polypeptide binding]; other site
378806004140	catalytic site [active]
378806004141	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
378806004142	L-serine binding site [chemical binding]; other site
378806004143	ACT domain interface; other site
378806004144	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806004145	active site
378806004146	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806004147	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
378806004148	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
378806004149	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
378806004150	catalytic site [active]
378806004151	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806004152	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806004153	active site
378806004154	ATP binding site [chemical binding]; other site
378806004155	substrate binding site [chemical binding]; other site
378806004156	activation loop (A-loop); other site
378806004157	Predicted ATPase [General function prediction only]; Region: COG3899
378806004158	AAA ATPase domain; Region: AAA_16; pfam13191
378806004159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004160	binding surface
378806004161	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004162	TPR motif; other site
378806004163	GAF domain; Region: GAF; pfam01590
378806004164	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806004165	dimer interface [polypeptide binding]; other site
378806004166	phosphorylation site [posttranslational modification]
378806004167	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
378806004168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806004169	ATP binding site [chemical binding]; other site
378806004170	Mg2+ binding site [ion binding]; other site
378806004171	G-X-G motif; other site
378806004172	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
378806004173	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
378806004174	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
378806004175	maleylacetoacetate isomerase; Region: maiA; TIGR01262
378806004176	C-terminal domain interface [polypeptide binding]; other site
378806004177	GSH binding site (G-site) [chemical binding]; other site
378806004178	putative dimer interface [polypeptide binding]; other site
378806004179	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
378806004180	dimer interface [polypeptide binding]; other site
378806004181	N-terminal domain interface [polypeptide binding]; other site
378806004182	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
378806004183	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
378806004184	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
378806004185	dimer interface [polypeptide binding]; other site
378806004186	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
378806004187	active site
378806004188	Fe binding site [ion binding]; other site
378806004189	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
378806004190	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819
378806004191	putative heme binding site [chemical binding]; other site
378806004192	putative substrate binding site [chemical binding]; other site
378806004193	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806004194	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
378806004195	Coenzyme A binding pocket [chemical binding]; other site
378806004196	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
378806004197	Coenzyme A binding pocket [chemical binding]; other site
378806004198	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
378806004199	PLD-like domain; Region: PLDc_2; pfam13091
378806004200	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
378806004201	putative active site [active]
378806004202	catalytic site [active]
378806004203	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806004204	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
378806004205	active site
378806004206	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
378806004207	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
378806004208	putative active site [active]
378806004209	putative NTP binding site [chemical binding]; other site
378806004210	putative nucleic acid binding site [nucleotide binding]; other site
378806004211	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
378806004212	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
378806004213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806004214	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806004215	active site
378806004216	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806004217	dimer interface [polypeptide binding]; other site
378806004218	phosphorylation site [posttranslational modification]
378806004219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806004220	ATP binding site [chemical binding]; other site
378806004221	Mg2+ binding site [ion binding]; other site
378806004222	G-X-G motif; other site
378806004223	Fatty-acid desaturase [Lipid metabolism]; Region: OLE1; cl17656
378806004224	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806004225	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806004226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806004227	dimer interface [polypeptide binding]; other site
378806004228	phosphorylation site [posttranslational modification]
378806004229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806004230	ATP binding site [chemical binding]; other site
378806004231	Mg2+ binding site [ion binding]; other site
378806004232	G-X-G motif; other site
378806004233	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
378806004234	putative active site [active]
378806004235	Zn binding site [ion binding]; other site
378806004236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806004237	Response regulator receiver domain; Region: Response_reg; pfam00072
378806004238	active site
378806004239	phosphorylation site [posttranslational modification]
378806004240	intermolecular recognition site; other site
378806004241	dimerization interface [polypeptide binding]; other site
378806004242	PAS fold; Region: PAS; pfam00989
378806004243	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806004244	putative active site [active]
378806004245	heme pocket [chemical binding]; other site
378806004246	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806004247	PAS fold; Region: PAS_3; pfam08447
378806004248	putative active site [active]
378806004249	heme pocket [chemical binding]; other site
378806004250	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806004251	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806004252	dimer interface [polypeptide binding]; other site
378806004253	phosphorylation site [posttranslational modification]
378806004254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806004255	ATP binding site [chemical binding]; other site
378806004256	Mg2+ binding site [ion binding]; other site
378806004257	G-X-G motif; other site
378806004258	Cupin; Region: Cupin_6; pfam12852
378806004259	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
378806004260	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806004261	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
378806004262	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
378806004263	FMN binding site [chemical binding]; other site
378806004264	active site
378806004265	substrate binding site [chemical binding]; other site
378806004266	catalytic residue [active]
378806004267	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
378806004268	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806004269	putative acyl-acceptor binding pocket; other site
378806004270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806004271	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
378806004272	dimer interface [polypeptide binding]; other site
378806004273	conserved gate region; other site
378806004274	putative PBP binding loops; other site
378806004275	ABC-ATPase subunit interface; other site
378806004276	spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187
378806004277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806004278	Q-loop/lid; other site
378806004279	ABC transporter signature motif; other site
378806004280	Walker B; other site
378806004281	D-loop; other site
378806004282	H-loop/switch region; other site
378806004283	TOBE domain; Region: TOBE; cl01440
378806004284	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
378806004285	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
378806004286	Walker A/P-loop; other site
378806004287	ATP binding site [chemical binding]; other site
378806004288	Q-loop/lid; other site
378806004289	ABC transporter signature motif; other site
378806004290	Walker B; other site
378806004291	D-loop; other site
378806004292	H-loop/switch region; other site
378806004293	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
378806004294	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806004295	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
378806004296	TM-ABC transporter signature motif; other site
378806004297	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
378806004298	TM-ABC transporter signature motif; other site
378806004299	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
378806004300	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
378806004301	putative ligand binding site [chemical binding]; other site
378806004302	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
378806004303	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806004304	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806004305	dimerization interface [polypeptide binding]; other site
378806004306	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806004307	dimer interface [polypeptide binding]; other site
378806004308	putative CheW interface [polypeptide binding]; other site
378806004309	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806004310	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806004311	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806004312	MAEBL; Provisional; Region: PTZ00121
378806004313	Protein kinase domain; Region: Pkinase; pfam00069
378806004314	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806004315	active site
378806004316	ATP binding site [chemical binding]; other site
378806004317	substrate binding site [chemical binding]; other site
378806004318	activation loop (A-loop); other site
378806004319	hypothetical protein; Provisional; Region: PRK06834
378806004320	hypothetical protein; Provisional; Region: PRK07236
378806004321	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
378806004322	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806004323	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806004324	putative sugar binding sites [chemical binding]; other site
378806004325	Q-X-W motif; other site
378806004326	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
378806004327	NADH(P)-binding; Region: NAD_binding_10; pfam13460
378806004328	putative NAD(P) binding site [chemical binding]; other site
378806004329	homodimer interface [polypeptide binding]; other site
378806004330	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004332	binding surface
378806004333	TPR motif; other site
378806004334	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004335	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004336	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004337	binding surface
378806004338	TPR motif; other site
378806004339	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004341	binding surface
378806004342	TPR motif; other site
378806004343	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004344	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004345	binding surface
378806004346	TPR motif; other site
378806004347	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004348	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004349	CHAT domain; Region: CHAT; pfam12770
378806004350	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806004351	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
378806004352	sugar binding site [chemical binding]; other site
378806004353	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
378806004354	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806004355	sugar binding site [chemical binding]; other site
378806004356	CARDB; Region: CARDB; pfam07705
378806004357	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
378806004358	putative metal binding site [ion binding]; other site
378806004359	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
378806004360	Right handed beta helix region; Region: Beta_helix; pfam13229
378806004361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806004362	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
378806004363	putative substrate translocation pore; other site
378806004364	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
378806004365	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806004366	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806004367	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806004368	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
378806004369	substrate binding pocket [chemical binding]; other site
378806004370	dimerization interface [polypeptide binding]; other site
378806004371	NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231
378806004372	NmrA-like family; Region: NmrA; pfam05368
378806004373	putative NADP binding site [chemical binding]; other site
378806004374	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
378806004375	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
378806004376	FMN binding site [chemical binding]; other site
378806004377	active site
378806004378	catalytic residues [active]
378806004379	substrate binding site [chemical binding]; other site
378806004380	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
378806004381	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
378806004382	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
378806004383	Cupin domain; Region: Cupin_2; pfam07883
378806004384	Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920
378806004385	putative active site [active]
378806004386	redox center [active]
378806004387	Thioredoxin; Region: Thioredoxin_4; cl17273
378806004388	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
378806004389	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
378806004390	putative rRNA binding site [nucleotide binding]; other site
378806004391	Amidinotransferase; Region: Amidinotransf; cl12043
378806004392	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
378806004393	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
378806004394	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
378806004395	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
378806004396	metal binding site [ion binding]; metal-binding site
378806004397	ligand binding site [chemical binding]; other site
378806004398	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
378806004399	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806004400	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806004401	Walker A motif; other site
378806004402	ATP binding site [chemical binding]; other site
378806004403	Walker B motif; other site
378806004404	arginine finger; other site
378806004405	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
378806004406	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
378806004407	PAAR motif; Region: PAAR_motif; pfam05488
378806004408	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
378806004409	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
378806004410	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
378806004411	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
378806004412	Phage protein D [General function prediction only]; Region: COG3500
378806004413	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
378806004414	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
378806004415	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
378806004416	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806004417	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806004418	active site
378806004419	catalytic tetrad [active]
378806004420	BNR repeat-like domain; Region: BNR_2; pfam13088
378806004421	PQQ-like domain; Region: PQQ_2; pfam13360
378806004422	PQQ-like domain; Region: PQQ_2; pfam13360
378806004423	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806004424	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
378806004425	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806004426	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
378806004427	substrate binding pocket [chemical binding]; other site
378806004428	dimerization interface [polypeptide binding]; other site
378806004429	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806004430	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806004431	active site
378806004432	short chain dehydrogenase; Provisional; Region: PRK05650
378806004433	classical (c) SDRs; Region: SDR_c; cd05233
378806004434	NAD(P) binding site [chemical binding]; other site
378806004435	active site
378806004436	Phosphotransferase enzyme family; Region: APH; pfam01636
378806004437	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
378806004438	putative active site [active]
378806004439	putative substrate binding site [chemical binding]; other site
378806004440	ATP binding site [chemical binding]; other site
378806004441	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806004442	Cytochrome P450; Region: p450; cl12078
378806004443	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
378806004444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806004445	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
378806004446	EamA-like transporter family; Region: EamA; pfam00892
378806004447	EamA-like transporter family; Region: EamA; pfam00892
378806004448	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
378806004449	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806004450	cyclase homology domain; Region: CHD; cd07302
378806004451	nucleotidyl binding site; other site
378806004452	metal binding site [ion binding]; metal-binding site
378806004453	dimer interface [polypeptide binding]; other site
378806004454	AAA ATPase domain; Region: AAA_16; pfam13191
378806004455	Predicted ATPase [General function prediction only]; Region: COG3903
378806004456	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004457	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004458	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004459	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
378806004460	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
378806004461	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806004462	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
378806004463	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
378806004464	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806004465	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
378806004466	Cytochrome c; Region: Cytochrom_C; cl11414
378806004467	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
378806004468	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
378806004469	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806004470	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806004471	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806004472	active site
378806004473	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806004474	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
378806004475	active site
378806004476	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806004477	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806004478	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
378806004479	putative NADP binding site [chemical binding]; other site
378806004480	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806004481	active site
378806004482	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806004483	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806004484	active site
378806004485	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806004486	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
378806004487	active site
378806004488	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806004489	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806004490	active site
378806004491	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806004492	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
378806004493	active site
378806004494	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806004495	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
378806004496	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
378806004497	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806004498	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
378806004499	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
378806004500	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
378806004501	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
378806004502	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
378806004503	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806004504	inhibitor-cofactor binding pocket; inhibition site
378806004505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806004506	catalytic residue [active]
378806004507	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
378806004508	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
378806004509	Glutamate binding site [chemical binding]; other site
378806004510	homodimer interface [polypeptide binding]; other site
378806004511	NAD binding site [chemical binding]; other site
378806004512	catalytic residues [active]
378806004513	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
378806004514	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806004515	inhibitor-cofactor binding pocket; inhibition site
378806004516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806004517	catalytic residue [active]
378806004518	PilZ domain; Region: PilZ; pfam07238
378806004519	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
378806004520	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
378806004521	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
378806004522	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
378806004523	Probable Catalytic site; other site
378806004524	metal-binding site
378806004525	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
378806004526	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
378806004527	active site
378806004528	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
378806004529	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806004530	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806004531	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
378806004532	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
378806004533	Mg++ binding site [ion binding]; other site
378806004534	putative catalytic motif [active]
378806004535	substrate binding site [chemical binding]; other site
378806004536	Predicted peptidase [General function prediction only]; Region: COG4099
378806004537	Family description; Region: VCBS; pfam13517
378806004538	Family description; Region: VCBS; pfam13517
378806004539	Family description; Region: VCBS; pfam13517
378806004540	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
378806004541	metal binding site [ion binding]; metal-binding site
378806004542	active site
378806004543	Family description; Region: VCBS; pfam13517
378806004544	Family description; Region: VCBS; pfam13517
378806004545	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
378806004546	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
378806004547	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
378806004548	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
378806004549	O-Antigen ligase; Region: Wzy_C; pfam04932
378806004550	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806004551	succinylarginine dihydrolase; Provisional; Region: PRK13281
378806004552	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
378806004553	putative acyl-acceptor binding pocket; other site
378806004554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
378806004555	OstA-like protein; Region: OstA; cl00844
378806004556	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
378806004557	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
378806004558	Walker A/P-loop; other site
378806004559	ATP binding site [chemical binding]; other site
378806004560	Q-loop/lid; other site
378806004561	ABC transporter signature motif; other site
378806004562	Walker B; other site
378806004563	D-loop; other site
378806004564	H-loop/switch region; other site
378806004565	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
378806004566	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
378806004567	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
378806004568	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
378806004569	exopolyphosphatase; Region: exo_poly_only; TIGR03706
378806004570	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
378806004571	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
378806004572	short chain dehydrogenase; Provisional; Region: PRK06701
378806004573	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
378806004574	NAD binding site [chemical binding]; other site
378806004575	metal binding site [ion binding]; metal-binding site
378806004576	active site
378806004577	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
378806004578	30S subunit binding site; other site
378806004579	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
378806004580	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
378806004581	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
378806004582	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
378806004583	active site
378806004584	phosphorylation site [posttranslational modification]
378806004585	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
378806004586	putative active site [active]
378806004587	dimerization interface [polypeptide binding]; other site
378806004588	putative tRNAtyr binding site [nucleotide binding]; other site
378806004589	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
378806004590	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
378806004591	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
378806004592	dimer interface [polypeptide binding]; other site
378806004593	ssDNA binding site [nucleotide binding]; other site
378806004594	tetramer (dimer of dimers) interface [polypeptide binding]; other site
378806004595	Ion transport protein; Region: Ion_trans; pfam00520
378806004596	Ion channel; Region: Ion_trans_2; pfam07885
378806004597	Double zinc ribbon; Region: DZR; pfam12773
378806004598	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
378806004599	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806004600	Cytochrome P450; Region: p450; cl12078
378806004601	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806004602	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806004603	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806004604	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806004605	active site
378806004606	ATP binding site [chemical binding]; other site
378806004607	substrate binding site [chemical binding]; other site
378806004608	activation loop (A-loop); other site
378806004609	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
378806004610	Iron-sulfur protein interface; other site
378806004611	proximal heme binding site [chemical binding]; other site
378806004612	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
378806004613	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
378806004614	dimerization interface [polypeptide binding]; other site
378806004615	domain crossover interface; other site
378806004616	redox-dependent activation switch; other site
378806004617	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
378806004618	active site
378806004619	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
378806004620	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
378806004621	G1 box; other site
378806004622	GTP/Mg2+ binding site [chemical binding]; other site
378806004623	G2 box; other site
378806004624	Switch I region; other site
378806004625	G3 box; other site
378806004626	Switch II region; other site
378806004627	G4 box; other site
378806004628	G5 box; other site
378806004629	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
378806004630	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
378806004631	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
378806004632	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
378806004633	PAS domain S-box; Region: sensory_box; TIGR00229
378806004634	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806004635	putative active site [active]
378806004636	heme pocket [chemical binding]; other site
378806004637	GAF domain; Region: GAF_3; pfam13492
378806004638	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806004639	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806004640	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806004641	dimer interface [polypeptide binding]; other site
378806004642	phosphorylation site [posttranslational modification]
378806004643	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806004644	ATP binding site [chemical binding]; other site
378806004645	Mg2+ binding site [ion binding]; other site
378806004646	G-X-G motif; other site
378806004647	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806004648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806004649	active site
378806004650	phosphorylation site [posttranslational modification]
378806004651	intermolecular recognition site; other site
378806004652	dimerization interface [polypeptide binding]; other site
378806004653	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806004654	Walker A motif; other site
378806004655	ATP binding site [chemical binding]; other site
378806004656	Walker B motif; other site
378806004657	arginine finger; other site
378806004658	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806004659	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
378806004660	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
378806004661	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
378806004662	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
378806004663	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
378806004664	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
378806004665	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
378806004666	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
378806004667	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
378806004668	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
378806004669	SLBB domain; Region: SLBB; pfam10531
378806004670	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
378806004671	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
378806004672	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
378806004673	putative dimer interface [polypeptide binding]; other site
378806004674	[2Fe-2S] cluster binding site [ion binding]; other site
378806004675	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806004676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806004677	active site
378806004678	phosphorylation site [posttranslational modification]
378806004679	intermolecular recognition site; other site
378806004680	dimerization interface [polypeptide binding]; other site
378806004681	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806004682	active site
378806004683	ATP binding site [chemical binding]; other site
378806004684	substrate binding site [chemical binding]; other site
378806004685	activation loop (A-loop); other site
378806004686	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806004687	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
378806004688	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
378806004689	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
378806004690	putative dimer interface [polypeptide binding]; other site
378806004691	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
378806004692	DNA binding residues [nucleotide binding]
378806004693	Response regulator receiver domain; Region: Response_reg; pfam00072
378806004694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806004695	active site
378806004696	phosphorylation site [posttranslational modification]
378806004697	intermolecular recognition site; other site
378806004698	dimerization interface [polypeptide binding]; other site
378806004699	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
378806004700	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
378806004701	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
378806004702	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
378806004703	CTP synthetase; Validated; Region: pyrG; PRK05380
378806004704	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
378806004705	Catalytic site [active]
378806004706	active site
378806004707	UTP binding site [chemical binding]; other site
378806004708	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
378806004709	active site
378806004710	putative oxyanion hole; other site
378806004711	catalytic triad [active]
378806004712	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
378806004713	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
378806004714	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
378806004715	Walker A/P-loop; other site
378806004716	ATP binding site [chemical binding]; other site
378806004717	Q-loop/lid; other site
378806004718	ABC transporter signature motif; other site
378806004719	Walker B; other site
378806004720	D-loop; other site
378806004721	H-loop/switch region; other site
378806004722	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806004723	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806004724	active site
378806004725	catalytic tetrad [active]
378806004726	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806004727	AAA domain; Region: AAA_23; pfam13476
378806004728	Walker A/P-loop; other site
378806004729	ATP binding site [chemical binding]; other site
378806004730	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806004731	Walker B; other site
378806004732	D-loop; other site
378806004733	H-loop/switch region; other site
378806004734	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
378806004735	Amidase; Region: Amidase; cl11426
378806004736	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806004737	active site
378806004738	ATP binding site [chemical binding]; other site
378806004739	substrate binding site [chemical binding]; other site
378806004740	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
378806004741	activation loop (A-loop); other site
378806004742	cyclase homology domain; Region: CHD; cd07302
378806004743	dimer interface [polypeptide binding]; other site
378806004744	nucleotidyl binding site; other site
378806004745	metal binding site [ion binding]; metal-binding site
378806004746	AAA ATPase domain; Region: AAA_16; pfam13191
378806004747	Amidohydrolase; Region: Amidohydro_2; pfam04909
378806004748	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
378806004749	YcaO-like family; Region: YcaO; pfam02624
378806004750	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
378806004751	Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848
378806004752	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806004753	Interdomain contacts; other site
378806004754	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
378806004755	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
378806004756	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
378806004757	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
378806004758	Ligand binding site; other site
378806004759	oligomer interface; other site
378806004760	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
378806004761	active site
378806004762	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
378806004763	homodimer interface [polypeptide binding]; other site
378806004764	GAF domain; Region: GAF_2; pfam13185
378806004765	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806004766	PAS fold; Region: PAS_3; pfam08447
378806004767	putative active site [active]
378806004768	heme pocket [chemical binding]; other site
378806004769	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806004770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806004771	ATP binding site [chemical binding]; other site
378806004772	Mg2+ binding site [ion binding]; other site
378806004773	G-X-G motif; other site
378806004774	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
378806004775	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806004776	RNA binding surface [nucleotide binding]; other site
378806004777	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806004778	active site
378806004779	amidophosphoribosyltransferase; Provisional; Region: PRK09123
378806004780	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
378806004781	active site
378806004782	tetramer interface [polypeptide binding]; other site
378806004783	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
378806004784	active site
378806004785	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
378806004786	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
378806004787	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806004788	HSP70 interaction site [polypeptide binding]; other site
378806004789	TPR repeat; Region: TPR_11; pfam13414
378806004790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004791	binding surface
378806004792	TPR motif; other site
378806004793	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
378806004794	hypothetical protein; Provisional; Region: PRK10621
378806004795	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
378806004796	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
378806004797	carboxyltransferase (CT) interaction site; other site
378806004798	biotinylation site [posttranslational modification]; other site
378806004799	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
378806004800	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
378806004801	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806004802	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
378806004803	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
378806004804	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
378806004805	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
378806004806	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
378806004807	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806004808	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
378806004809	acyl-activating enzyme (AAE) consensus motif; other site
378806004810	putative AMP binding site [chemical binding]; other site
378806004811	putative active site [active]
378806004812	putative CoA binding site [chemical binding]; other site
378806004813	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806004814	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806004815	active site
378806004816	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806004817	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806004818	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806004819	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
378806004820	Enoylreductase; Region: PKS_ER; smart00829
378806004821	NAD(P) binding site [chemical binding]; other site
378806004822	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806004823	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806004824	putative NADP binding site [chemical binding]; other site
378806004825	active site
378806004826	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806004827	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806004828	FcoT-like thioesterase domain; Region: FcoT; pfam10862
378806004829	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
378806004830	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
378806004831	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
378806004832	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
378806004833	[2Fe-2S] cluster binding site [ion binding]; other site
378806004834	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
378806004835	hydrophobic ligand binding site; other site
378806004836	MAEBL; Provisional; Region: PTZ00121
378806004837	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
378806004838	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
378806004839	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
378806004840	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
378806004841	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
378806004842	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
378806004843	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
378806004844	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
378806004845	active site
378806004846	Zn binding site [ion binding]; other site
378806004847	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
378806004848	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
378806004849	nucleotide binding site [chemical binding]; other site
378806004850	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806004851	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
378806004852	active site
378806004853	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
378806004854	Part of AAA domain; Region: AAA_19; pfam13245
378806004855	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806004856	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806004857	DNA-binding site [nucleotide binding]; DNA binding site
378806004858	Cupin domain; Region: Cupin_2; cl17218
378806004859	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806004860	S-adenosylmethionine binding site [chemical binding]; other site
378806004861	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
378806004862	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
378806004863	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
378806004864	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806004865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806004866	active site
378806004867	phosphorylation site [posttranslational modification]
378806004868	intermolecular recognition site; other site
378806004869	dimerization interface [polypeptide binding]; other site
378806004870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806004871	ATP binding site [chemical binding]; other site
378806004872	Walker A motif; other site
378806004873	Walker B motif; other site
378806004874	arginine finger; other site
378806004875	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806004876	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806004877	dimer interface [polypeptide binding]; other site
378806004878	phosphorylation site [posttranslational modification]
378806004879	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806004880	ATP binding site [chemical binding]; other site
378806004881	Mg2+ binding site [ion binding]; other site
378806004882	G-X-G motif; other site
378806004883	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806004884	HEAT repeats; Region: HEAT_2; pfam13646
378806004885	RDD family; Region: RDD; pfam06271
378806004886	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
378806004887	Protein of unknown function (DUF962); Region: DUF962; cl01879
378806004888	Penicillinase repressor; Region: Pencillinase_R; pfam03965
378806004889	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
378806004890	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
378806004891	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
378806004892	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806004893	S-adenosylmethionine binding site [chemical binding]; other site
378806004894	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806004895	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806004896	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806004897	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806004898	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806004899	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806004900	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
378806004901	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806004902	FeS/SAM binding site; other site
378806004903	HemN C-terminal domain; Region: HemN_C; pfam06969
378806004904	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
378806004905	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
378806004906	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
378806004907	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
378806004908	PKC phosphorylation site [posttranslational modification]; other site
378806004909	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
378806004910	active site
378806004911	catalytic residues [active]
378806004912	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
378806004913	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
378806004914	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806004915	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806004916	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
378806004917	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
378806004918	catalytic loop [active]
378806004919	iron binding site [ion binding]; other site
378806004920	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
378806004921	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
378806004922	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806004923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004924	TPR motif; other site
378806004925	binding surface
378806004926	HEAT repeats; Region: HEAT_2; pfam13646
378806004927	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806004928	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806004929	active site
378806004930	ATP binding site [chemical binding]; other site
378806004931	substrate binding site [chemical binding]; other site
378806004932	activation loop (A-loop); other site
378806004933	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004934	Tetratricopeptide repeat; Region: TPR_10; pfam13374
378806004935	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004937	binding surface
378806004938	TPR motif; other site
378806004939	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004940	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004941	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806004942	binding surface
378806004943	TPR motif; other site
378806004944	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004945	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806004946	RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001
378806004947	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
378806004948	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806004949	ATP binding site [chemical binding]; other site
378806004950	putative Mg++ binding site [ion binding]; other site
378806004951	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806004952	nucleotide binding region [chemical binding]; other site
378806004953	ATP-binding site [chemical binding]; other site
378806004954	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
378806004955	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
378806004956	putative NAD(P) binding site [chemical binding]; other site
378806004957	dimer interface [polypeptide binding]; other site
378806004958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806004959	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806004960	NAD(P) binding site [chemical binding]; other site
378806004961	active site
378806004962	short chain dehydrogenase; Provisional; Region: PRK06172
378806004963	classical (c) SDRs; Region: SDR_c; cd05233
378806004964	NAD(P) binding site [chemical binding]; other site
378806004965	active site
378806004966	H+ Antiporter protein; Region: 2A0121; TIGR00900
378806004967	MOSC domain; Region: MOSC; pfam03473
378806004968	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806004969	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806004970	active site
378806004971	ATP binding site [chemical binding]; other site
378806004972	substrate binding site [chemical binding]; other site
378806004973	activation loop (A-loop); other site
378806004974	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
378806004975	HTH domain; Region: HTH_11; pfam08279
378806004976	WYL domain; Region: WYL; pfam13280
378806004977	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
378806004978	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
378806004979	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
378806004980	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
378806004981	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
378806004982	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
378806004983	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
378806004984	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
378806004985	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
378806004986	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
378806004987	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
378806004988	Immunoglobulin domain; Region: Ig; cl11960
378806004989	Immunoglobulin I-set domain; Region: I-set; pfam07679
378806004990	Immunoglobulin domain; Region: Ig; cl11960
378806004991	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806004992	sugar binding site [chemical binding]; other site
378806004993	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
378806004994	Immunoglobulin domain; Region: Ig; cl11960
378806004995	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806004996	Interdomain contacts; other site
378806004997	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806004998	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806004999	Putative cyclase; Region: Cyclase; pfam04199
378806005000	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
378806005001	active site
378806005002	NTP binding site [chemical binding]; other site
378806005003	metal binding triad [ion binding]; metal-binding site
378806005004	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
378806005005	RibD C-terminal domain; Region: RibD_C; cl17279
378806005006	Kelch domain; Region: Kelch; smart00612
378806005007	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806005008	Kelch domain; Region: Kelch; smart00612
378806005009	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806005010	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806005011	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806005012	Kelch domain; Region: Kelch; smart00612
378806005013	Kelch domain; Region: Kelch; smart00612
378806005014	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806005015	Kelch domain; Region: Kelch; smart00612
378806005016	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
378806005017	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
378806005018	putative ligand binding site [chemical binding]; other site
378806005019	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
378806005020	Transcriptional regulator; Region: Rrf2; pfam02082
378806005021	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
378806005022	putative ABC transporter; Region: ycf24; CHL00085
378806005023	FeS assembly ATPase SufC; Region: sufC; TIGR01978
378806005024	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
378806005025	Walker A/P-loop; other site
378806005026	ATP binding site [chemical binding]; other site
378806005027	Q-loop/lid; other site
378806005028	ABC transporter signature motif; other site
378806005029	Walker B; other site
378806005030	D-loop; other site
378806005031	H-loop/switch region; other site
378806005032	FeS assembly protein SufD; Region: sufD; TIGR01981
378806005033	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
378806005034	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
378806005035	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
378806005036	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806005037	catalytic residue [active]
378806005038	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
378806005039	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
378806005040	trimerization site [polypeptide binding]; other site
378806005041	active site
378806005042	Domain of unknown function DUF59; Region: DUF59; cl00941
378806005043	Response regulator receiver domain; Region: Response_reg; pfam00072
378806005044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806005045	active site
378806005046	phosphorylation site [posttranslational modification]
378806005047	intermolecular recognition site; other site
378806005048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806005049	dimerization interface [polypeptide binding]; other site
378806005050	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806005051	dimer interface [polypeptide binding]; other site
378806005052	phosphorylation site [posttranslational modification]
378806005053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806005054	ATP binding site [chemical binding]; other site
378806005055	Mg2+ binding site [ion binding]; other site
378806005056	G-X-G motif; other site
378806005057	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
378806005058	intracellular protease, PfpI family; Region: PfpI; TIGR01382
378806005059	proposed catalytic triad [active]
378806005060	conserved cys residue [active]
378806005061	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
378806005062	catalytic nucleophile [active]
378806005063	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005064	binding surface
378806005065	TPR motif; other site
378806005066	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
378806005067	Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970
378806005068	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806005069	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005070	active site
378806005071	ATP binding site [chemical binding]; other site
378806005072	substrate binding site [chemical binding]; other site
378806005073	activation loop (A-loop); other site
378806005074	GAF domain; Region: GAF; cl17456
378806005075	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806005076	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806005077	dimer interface [polypeptide binding]; other site
378806005078	phosphorylation site [posttranslational modification]
378806005079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806005080	ATP binding site [chemical binding]; other site
378806005081	Mg2+ binding site [ion binding]; other site
378806005082	G-X-G motif; other site
378806005083	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806005084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806005085	active site
378806005086	phosphorylation site [posttranslational modification]
378806005087	intermolecular recognition site; other site
378806005088	dimerization interface [polypeptide binding]; other site
378806005089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806005090	Walker A motif; other site
378806005091	ATP binding site [chemical binding]; other site
378806005092	Walker B motif; other site
378806005093	arginine finger; other site
378806005094	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806005095	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806005096	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806005097	glutathione reductase; Validated; Region: PRK06116
378806005098	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
378806005099	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
378806005100	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
378806005101	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806005102	substrate binding site [chemical binding]; other site
378806005103	oxyanion hole (OAH) forming residues; other site
378806005104	trimer interface [polypeptide binding]; other site
378806005105	RDD family; Region: RDD; pfam06271
378806005106	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
378806005107	Predicted esterase [General function prediction only]; Region: COG0400
378806005108	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
378806005109	active site
378806005110	PGAP1-like protein; Region: PGAP1; pfam07819
378806005111	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
378806005112	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
378806005113	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
378806005114	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
378806005115	spermidine synthase; Provisional; Region: PRK03612
378806005116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806005117	S-adenosylmethionine binding site [chemical binding]; other site
378806005118	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806005119	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
378806005120	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806005121	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806005122	ligand binding site [chemical binding]; other site
378806005123	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
378806005124	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
378806005125	Protein of unknown function (DUF1305); Region: DUF1305; cl01404
378806005126	type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358
378806005127	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
378806005128	Protein of unknown function (DUF877); Region: DUF877; pfam05943
378806005129	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
378806005130	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
378806005131	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
378806005132	Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462
378806005133	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
378806005134	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
378806005135	hypothetical protein; Validated; Region: PRK09039
378806005136	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
378806005137	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
378806005138	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
378806005139	active site
378806005140	homotetramer interface [polypeptide binding]; other site
378806005141	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
378806005142	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
378806005143	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806005144	Domain of unknown function (DUF955); Region: DUF955; cl01076
378806005145	HerA helicase [Replication, recombination, and repair]; Region: COG0433
378806005146	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005147	binding surface
378806005148	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806005149	TPR motif; other site
378806005150	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
378806005151	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
378806005152	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806005153	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
378806005154	phosphoglyceromutase; Provisional; Region: PRK05434
378806005155	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
378806005156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806005157	dimer interface [polypeptide binding]; other site
378806005158	phosphorylation site [posttranslational modification]
378806005159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806005160	ATP binding site [chemical binding]; other site
378806005161	G-X-G motif; other site
378806005162	SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833
378806005163	active site
378806005164	catalytic triad [active]
378806005165	oxyanion hole [active]
378806005166	Family description; Region: VCBS; pfam13517
378806005167	Family description; Region: VCBS; pfam13517
378806005168	Family description; Region: VCBS; pfam13517
378806005169	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
378806005170	Pectinacetylesterase; Region: PAE; pfam03283
378806005171	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806005172	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806005173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
378806005174	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
378806005175	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
378806005176	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
378806005177	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
378806005178	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005179	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005180	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005181	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806005182	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005183	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005184	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806005185	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005186	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005187	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005188	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806005189	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005190	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005191	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806005192	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806005193	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
378806005194	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
378806005195	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
378806005196	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
378806005197	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806005198	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
378806005199	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806005200	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806005201	DNA-binding site [nucleotide binding]; DNA binding site
378806005202	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806005203	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
378806005204	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
378806005205	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
378806005206	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
378806005207	putative catalytic cysteine [active]
378806005208	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005209	TPR motif; other site
378806005210	TPR repeat; Region: TPR_11; pfam13414
378806005211	binding surface
378806005212	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
378806005213	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806005214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806005215	active site
378806005216	phosphorylation site [posttranslational modification]
378806005217	intermolecular recognition site; other site
378806005218	dimerization interface [polypeptide binding]; other site
378806005219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806005220	Walker A motif; other site
378806005221	ATP binding site [chemical binding]; other site
378806005222	Walker B motif; other site
378806005223	arginine finger; other site
378806005224	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806005225	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
378806005226	nudix motif; other site
378806005227	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
378806005228	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806005229	HAMP domain; Region: HAMP; pfam00672
378806005230	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806005231	dimer interface [polypeptide binding]; other site
378806005232	putative CheW interface [polypeptide binding]; other site
378806005233	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
378806005234	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806005235	motif II; other site
378806005236	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
378806005237	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
378806005238	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
378806005239	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
378806005240	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
378806005241	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
378806005242	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
378806005243	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
378806005244	Walker A/P-loop; other site
378806005245	ATP binding site [chemical binding]; other site
378806005246	Q-loop/lid; other site
378806005247	ABC transporter signature motif; other site
378806005248	Walker B; other site
378806005249	D-loop; other site
378806005250	H-loop/switch region; other site
378806005251	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
378806005252	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
378806005253	substrate binding pocket [chemical binding]; other site
378806005254	membrane-bound complex binding site; other site
378806005255	hinge residues; other site
378806005256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806005257	dimer interface [polypeptide binding]; other site
378806005258	conserved gate region; other site
378806005259	putative PBP binding loops; other site
378806005260	ABC-ATPase subunit interface; other site
378806005261	MbtH-like protein; Region: MbtH; cl01279
378806005262	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
378806005263	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
378806005264	DNA-binding site [nucleotide binding]; DNA binding site
378806005265	RNA-binding motif; other site
378806005266	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
378806005267	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806005268	Cytochrome P450; Region: p450; cl12078
378806005269	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806005270	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806005271	dimerization interface [polypeptide binding]; other site
378806005272	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806005273	dimer interface [polypeptide binding]; other site
378806005274	phosphorylation site [posttranslational modification]
378806005275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806005276	ATP binding site [chemical binding]; other site
378806005277	Mg2+ binding site [ion binding]; other site
378806005278	G-X-G motif; other site
378806005279	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
378806005280	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
378806005281	TrkA-N domain; Region: TrkA_N; pfam02254
378806005282	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
378806005283	potassium/proton antiporter; Reviewed; Region: PRK05326
378806005284	TrkA-C domain; Region: TrkA_C; pfam02080
378806005285	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
378806005286	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
378806005287	TrkA-C domain; Region: TrkA_C; pfam02080
378806005288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806005289	Response regulator receiver domain; Region: Response_reg; pfam00072
378806005290	active site
378806005291	phosphorylation site [posttranslational modification]
378806005292	intermolecular recognition site; other site
378806005293	dimerization interface [polypeptide binding]; other site
378806005294	PAS fold; Region: PAS; pfam00989
378806005295	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806005296	putative active site [active]
378806005297	heme pocket [chemical binding]; other site
378806005298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806005299	PAS fold; Region: PAS_3; pfam08447
378806005300	putative active site [active]
378806005301	heme pocket [chemical binding]; other site
378806005302	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806005303	PAS domain; Region: PAS_9; pfam13426
378806005304	putative active site [active]
378806005305	heme pocket [chemical binding]; other site
378806005306	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806005307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806005308	dimer interface [polypeptide binding]; other site
378806005309	phosphorylation site [posttranslational modification]
378806005310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806005311	ATP binding site [chemical binding]; other site
378806005312	Mg2+ binding site [ion binding]; other site
378806005313	G-X-G motif; other site
378806005314	DNA repair protein RadA; Provisional; Region: PRK11823
378806005315	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
378806005316	Walker A motif/ATP binding site; other site
378806005317	ATP binding site [chemical binding]; other site
378806005318	Walker B motif; other site
378806005319	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
378806005320	biotin synthase; Region: bioB; TIGR00433
378806005321	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806005322	FeS/SAM binding site; other site
378806005323	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
378806005324	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
378806005325	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
378806005326	substrate-cofactor binding pocket; other site
378806005327	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806005328	catalytic residue [active]
378806005329	AAA domain; Region: AAA_26; pfam13500
378806005330	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
378806005331	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
378806005332	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806005333	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806005334	homodimer interface [polypeptide binding]; other site
378806005335	catalytic residue [active]
378806005336	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
378806005337	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
378806005338	ligand binding site [chemical binding]; other site
378806005339	TPR repeat; Region: TPR_11; pfam13414
378806005340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005341	binding surface
378806005342	TPR motif; other site
378806005343	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
378806005344	active site
378806005345	substrate-binding site [chemical binding]; other site
378806005346	metal-binding site [ion binding]
378806005347	GTP binding site [chemical binding]; other site
378806005348	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
378806005349	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
378806005350	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
378806005351	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
378806005352	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
378806005353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
378806005354	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
378806005355	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
378806005356	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494
378806005357	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
378806005358	Na binding site [ion binding]; other site
378806005359	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
378806005360	active site
378806005361	dinuclear metal binding site [ion binding]; other site
378806005362	dimerization interface [polypeptide binding]; other site
378806005363	Predicted acetyltransferase [General function prediction only]; Region: COG3393
378806005364	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
378806005365	Predicted oxidoreductase [General function prediction only]; Region: COG3573
378806005366	PAS domain; Region: PAS_9; pfam13426
378806005367	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806005368	putative active site [active]
378806005369	heme pocket [chemical binding]; other site
378806005370	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806005371	dimer interface [polypeptide binding]; other site
378806005372	phosphorylation site [posttranslational modification]
378806005373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806005374	ATP binding site [chemical binding]; other site
378806005375	Mg2+ binding site [ion binding]; other site
378806005376	G-X-G motif; other site
378806005377	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
378806005378	active site
378806005379	HIGH motif; other site
378806005380	nucleotide binding site [chemical binding]; other site
378806005381	active site
378806005382	KMSKS motif; other site
378806005383	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005384	TPR repeat; Region: TPR_11; pfam13414
378806005385	TPR motif; other site
378806005386	binding surface
378806005387	PEGA domain; Region: PEGA; pfam08308
378806005388	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806005389	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
378806005390	active site
378806005391	metal binding site [ion binding]; metal-binding site
378806005392	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
378806005393	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806005394	FeS/SAM binding site; other site
378806005395	Chitin binding domain; Region: Chitin_bind_3; pfam03067
378806005396	cyclophilin_ABH_like: Cyclophilin  A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; Region: cyclophilin_ABH_like; cd01926
378806005397	active site
378806005398	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
378806005399	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806005400	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806005401	DNA binding residues [nucleotide binding]
378806005402	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
378806005403	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
378806005404	intersubunit interface [polypeptide binding]; other site
378806005405	active site
378806005406	Zn2+ binding site [ion binding]; other site
378806005407	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806005408	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
378806005409	TM-ABC transporter signature motif; other site
378806005410	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806005411	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
378806005412	TM-ABC transporter signature motif; other site
378806005413	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
378806005414	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
378806005415	Walker A/P-loop; other site
378806005416	ATP binding site [chemical binding]; other site
378806005417	Q-loop/lid; other site
378806005418	ABC transporter signature motif; other site
378806005419	Walker B; other site
378806005420	D-loop; other site
378806005421	H-loop/switch region; other site
378806005422	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
378806005423	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
378806005424	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
378806005425	putative ligand binding site [chemical binding]; other site
378806005426	L-arabinose isomerase; Provisional; Region: PRK02929
378806005427	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
378806005428	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
378806005429	trimer interface [polypeptide binding]; other site
378806005430	putative substrate binding site [chemical binding]; other site
378806005431	putative metal binding site [ion binding]; other site
378806005432	ribulokinase; Provisional; Region: PRK04123
378806005433	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806005434	nucleotide binding site [chemical binding]; other site
378806005435	Transcriptional regulators [Transcription]; Region: PurR; COG1609
378806005436	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
378806005437	DNA binding site [nucleotide binding]
378806005438	domain linker motif; other site
378806005439	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
378806005440	ligand binding site [chemical binding]; other site
378806005441	dimerization interface (open form) [polypeptide binding]; other site
378806005442	dimerization interface (closed form) [polypeptide binding]; other site
378806005443	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
378806005444	GIY-YIG motif/motif A; other site
378806005445	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
378806005446	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
378806005447	active site
378806005448	FMN binding site [chemical binding]; other site
378806005449	substrate binding site [chemical binding]; other site
378806005450	homotetramer interface [polypeptide binding]; other site
378806005451	catalytic residue [active]
378806005452	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806005453	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005454	active site
378806005455	ATP binding site [chemical binding]; other site
378806005456	substrate binding site [chemical binding]; other site
378806005457	activation loop (A-loop); other site
378806005458	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806005459	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
378806005460	C factor cell-cell signaling protein; Provisional; Region: PRK09009
378806005461	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
378806005462	NADP binding site [chemical binding]; other site
378806005463	homodimer interface [polypeptide binding]; other site
378806005464	active site
378806005465	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
378806005466	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
378806005467	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
378806005468	glycogen synthase; Provisional; Region: glgA; PRK00654
378806005469	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
378806005470	ADP-binding pocket [chemical binding]; other site
378806005471	homodimer interface [polypeptide binding]; other site
378806005472	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806005473	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005474	active site
378806005475	ATP binding site [chemical binding]; other site
378806005476	substrate binding site [chemical binding]; other site
378806005477	activation loop (A-loop); other site
378806005478	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806005479	Domain of unknown function DUF21; Region: DUF21; pfam01595
378806005480	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
378806005481	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
378806005482	Transporter associated domain; Region: CorC_HlyC; smart01091
378806005483	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
378806005484	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
378806005485	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
378806005486	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806005487	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806005488	DNA-binding site [nucleotide binding]; DNA binding site
378806005489	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806005490	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
378806005491	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
378806005492	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
378806005493	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
378806005494	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
378806005495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
378806005496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005497	TPR motif; other site
378806005498	binding surface
378806005499	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
378806005500	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005501	binding surface
378806005502	TPR motif; other site
378806005503	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005504	binding surface
378806005505	TPR motif; other site
378806005506	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005507	binding surface
378806005508	TPR motif; other site
378806005509	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806005510	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005511	binding surface
378806005512	TPR motif; other site
378806005513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005514	TPR motif; other site
378806005515	binding surface
378806005516	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806005517	phosphopeptide binding site; other site
378806005518	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
378806005519	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
378806005520	putative sugar binding sites [chemical binding]; other site
378806005521	Q-X-W motif; other site
378806005522	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
378806005523	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005524	active site
378806005525	ATP binding site [chemical binding]; other site
378806005526	substrate binding site [chemical binding]; other site
378806005527	activation loop (A-loop); other site
378806005528	Protein kinase domain; Region: Pkinase; pfam00069
378806005529	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005530	active site
378806005531	ATP binding site [chemical binding]; other site
378806005532	substrate binding site [chemical binding]; other site
378806005533	activation loop (A-loop); other site
378806005534	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806005535	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
378806005536	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806005537	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806005538	Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200
378806005539	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
378806005540	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806005541	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806005542	non-specific DNA binding site [nucleotide binding]; other site
378806005543	salt bridge; other site
378806005544	sequence-specific DNA binding site [nucleotide binding]; other site
378806005545	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005546	active site
378806005547	ATP binding site [chemical binding]; other site
378806005548	substrate binding site [chemical binding]; other site
378806005549	activation loop (A-loop); other site
378806005550	Protein kinase domain; Region: Pkinase; pfam00069
378806005551	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005552	active site
378806005553	ATP binding site [chemical binding]; other site
378806005554	substrate binding site [chemical binding]; other site
378806005555	activation loop (A-loop); other site
378806005556	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806005557	Helix-turn-helix domain; Region: HTH_17; pfam12728
378806005558	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806005559	active site
378806005560	DNA binding site [nucleotide binding]
378806005561	Int/Topo IB signature motif; other site
378806005562	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806005563	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005564	active site
378806005565	substrate binding site [chemical binding]; other site
378806005566	ATP binding site [chemical binding]; other site
378806005567	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806005568	substrate binding site [chemical binding]; other site
378806005569	activation loop (A-loop); other site
378806005570	activation loop (A-loop); other site
378806005571	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806005572	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005573	active site
378806005574	ATP binding site [chemical binding]; other site
378806005575	substrate binding site [chemical binding]; other site
378806005576	activation loop (A-loop); other site
378806005577	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806005578	Phage capsid family; Region: Phage_capsid; pfam05065
378806005579	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
378806005580	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
378806005581	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
378806005582	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806005583	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806005584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806005585	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806005586	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806005587	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806005588	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806005589	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
378806005590	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806005591	NAD(P) binding site [chemical binding]; other site
378806005592	active site
378806005593	oxidoreductase; Provisional; Region: PRK06196
378806005594	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806005595	NAD(P) binding site [chemical binding]; other site
378806005596	active site
378806005597	EamA-like transporter family; Region: EamA; pfam00892
378806005598	EamA-like transporter family; Region: EamA; pfam00892
378806005599	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806005600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005601	TPR motif; other site
378806005602	binding surface
378806005603	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806005604	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806005605	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005606	binding surface
378806005607	TPR motif; other site
378806005608	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806005609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005610	TPR motif; other site
378806005611	binding surface
378806005612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005613	TPR motif; other site
378806005614	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806005615	binding surface
378806005616	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806005617	CHAT domain; Region: CHAT; pfam12770
378806005618	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
378806005619	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806005620	TPR repeat; Region: TPR_11; pfam13414
378806005621	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806005622	binding surface
378806005623	TPR motif; other site
378806005624	TPR repeat; Region: TPR_11; pfam13414
378806005625	SnoaL-like domain; Region: SnoaL_2; pfam12680
378806005626	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
378806005627	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
378806005628	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
378806005629	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
378806005630	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806005631	active site
378806005632	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806005633	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
378806005634	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
378806005635	High-affinity nickel-transport protein; Region: NicO; cl00964
378806005636	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
378806005637	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806005638	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
378806005639	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
378806005640	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
378806005641	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
378806005642	putative substrate binding site [chemical binding]; other site
378806005643	active site
378806005644	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
378806005645	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806005646	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806005647	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806005648	aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429
378806005649	FAD binding domain; Region: FAD_binding_4; pfam01565
378806005650	Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265
378806005651	Cytochrome P450; Region: p450; cl12078
378806005652	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806005653	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
378806005654	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806005655	Bacterial SH3 domain; Region: SH3_3; cl17532
378806005656	Domain of unknown function (DUF932); Region: DUF932; cl12129
378806005657	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
378806005658	Putative transposase; Region: Y2_Tnp; pfam04986
378806005659	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806005660	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
378806005661	dimer interface [polypeptide binding]; other site
378806005662	Transposase domain (DUF772); Region: DUF772; pfam05598
378806005663	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
378806005664	putative active site [active]
378806005665	putative metal binding site [ion binding]; other site
378806005666	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806005667	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806005668	structural tetrad; other site
378806005669	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806005670	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806005671	structural tetrad; other site
378806005672	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806005673	structural tetrad; other site
378806005674	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806005675	AAA domain; Region: AAA_14; pfam13173
378806005676	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
378806005677	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
378806005678	metal ion-dependent adhesion site (MIDAS); other site
378806005679	von Willebrand factor type A domain; Region: VWA_2; pfam13519
378806005680	metal ion-dependent adhesion site (MIDAS); other site
378806005681	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
378806005682	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
378806005683	N- and C-terminal domain interface [polypeptide binding]; other site
378806005684	active site
378806005685	MgATP binding site [chemical binding]; other site
378806005686	catalytic site [active]
378806005687	metal binding site [ion binding]; metal-binding site
378806005688	xylulose binding site [chemical binding]; other site
378806005689	homodimer interface [polypeptide binding]; other site
378806005690	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
378806005691	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
378806005692	putative substrate binding site [chemical binding]; other site
378806005693	putative ATP binding site [chemical binding]; other site
378806005694	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
378806005695	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
378806005696	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
378806005697	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
378806005698	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
378806005699	Walker A/P-loop; other site
378806005700	ATP binding site [chemical binding]; other site
378806005701	Q-loop/lid; other site
378806005702	ABC transporter signature motif; other site
378806005703	Walker B; other site
378806005704	D-loop; other site
378806005705	H-loop/switch region; other site
378806005706	TOBE domain; Region: TOBE; pfam03459
378806005707	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
378806005708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806005709	dimer interface [polypeptide binding]; other site
378806005710	conserved gate region; other site
378806005711	putative PBP binding loops; other site
378806005712	ABC-ATPase subunit interface; other site
378806005713	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
378806005714	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806005715	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
378806005716	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
378806005717	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005718	active site
378806005719	ATP binding site [chemical binding]; other site
378806005720	substrate binding site [chemical binding]; other site
378806005721	activation loop (A-loop); other site
378806005722	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
378806005723	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
378806005724	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806005725	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
378806005726	FAD binding domain; Region: FAD_binding_4; pfam01565
378806005727	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
378806005728	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
378806005729	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
378806005730	catalytic loop [active]
378806005731	iron binding site [ion binding]; other site
378806005732	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
378806005733	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
378806005734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806005735	S-adenosylmethionine binding site [chemical binding]; other site
378806005736	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
378806005737	classical (c) SDRs; Region: SDR_c; cd05233
378806005738	active site
378806005739	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
378806005740	dimerization interface [polypeptide binding]; other site
378806005741	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806005742	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
378806005743	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806005744	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
378806005745	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
378806005746	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
378806005747	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
378806005748	active site
378806005749	Zn binding site [ion binding]; other site
378806005750	Uncharacterized conserved protein [Function unknown]; Region: COG3268
378806005751	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
378806005752	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
378806005753	dimer interface [polypeptide binding]; other site
378806005754	ADP-ribose binding site [chemical binding]; other site
378806005755	active site
378806005756	nudix motif; other site
378806005757	metal binding site [ion binding]; metal-binding site
378806005758	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806005759	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806005760	LysR substrate binding domain; Region: LysR_substrate; pfam03466
378806005761	dimerization interface [polypeptide binding]; other site
378806005762	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
378806005763	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
378806005764	dimer interface [polypeptide binding]; other site
378806005765	active site
378806005766	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806005767	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806005768	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806005769	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
378806005770	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
378806005771	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
378806005772	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
378806005773	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806005774	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806005775	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
378806005776	putative substrate binding pocket [chemical binding]; other site
378806005777	putative dimerization interface [polypeptide binding]; other site
378806005778	Methyltransferase domain; Region: Methyltransf_24; pfam13578
378806005779	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806005780	classical (c) SDRs; Region: SDR_c; cd05233
378806005781	NAD(P) binding site [chemical binding]; other site
378806005782	active site
378806005783	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
378806005784	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806005785	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005786	active site
378806005787	ATP binding site [chemical binding]; other site
378806005788	substrate binding site [chemical binding]; other site
378806005789	activation loop (A-loop); other site
378806005790	trimethyllysine dioxygenase; Region: carnitine_TMLD; TIGR02410
378806005791	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
378806005792	active site
378806005793	iron coordination sites [ion binding]; other site
378806005794	substrate binding pocket [chemical binding]; other site
378806005795	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
378806005796	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
378806005797	putative NAD(P) binding site [chemical binding]; other site
378806005798	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
378806005799	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
378806005800	DAK2 domain; Region: Dak2; cl03685
378806005801	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
378806005802	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
378806005803	active pocket/dimerization site; other site
378806005804	active site
378806005805	phosphorylation site [posttranslational modification]
378806005806	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
378806005807	dimerization domain swap beta strand [polypeptide binding]; other site
378806005808	regulatory protein interface [polypeptide binding]; other site
378806005809	active site
378806005810	regulatory phosphorylation site [posttranslational modification]; other site
378806005811	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
378806005812	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
378806005813	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
378806005814	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
378806005815	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
378806005816	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806005817	catalytic triad [active]
378806005818	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
378806005819	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806005820	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806005821	phosphopeptide binding site; other site
378806005822	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806005823	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806005824	Walker A motif; other site
378806005825	ATP binding site [chemical binding]; other site
378806005826	Walker B motif; other site
378806005827	arginine finger; other site
378806005828	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
378806005829	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
378806005830	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
378806005831	active site
378806005832	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
378806005833	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806005834	active site
378806005835	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
378806005836	Methyltransferase domain; Region: Methyltransf_18; pfam12847
378806005837	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806005838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806005839	active site
378806005840	phosphorylation site [posttranslational modification]
378806005841	intermolecular recognition site; other site
378806005842	dimerization interface [polypeptide binding]; other site
378806005843	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806005844	DNA binding site [nucleotide binding]
378806005845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806005846	dimer interface [polypeptide binding]; other site
378806005847	phosphorylation site [posttranslational modification]
378806005848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806005849	ATP binding site [chemical binding]; other site
378806005850	Mg2+ binding site [ion binding]; other site
378806005851	G-X-G motif; other site
378806005852	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
378806005853	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
378806005854	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
378806005855	Cupin domain; Region: Cupin_2; cl17218
378806005856	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
378806005857	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
378806005858	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
378806005859	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
378806005860	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
378806005861	HflX GTPase family; Region: HflX; cd01878
378806005862	G1 box; other site
378806005863	GTP/Mg2+ binding site [chemical binding]; other site
378806005864	Switch I region; other site
378806005865	G2 box; other site
378806005866	G3 box; other site
378806005867	Switch II region; other site
378806005868	G4 box; other site
378806005869	G5 box; other site
378806005870	gamma-glutamyl kinase; Provisional; Region: PRK05429
378806005871	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
378806005872	nucleotide binding site [chemical binding]; other site
378806005873	homotetrameric interface [polypeptide binding]; other site
378806005874	putative phosphate binding site [ion binding]; other site
378806005875	putative allosteric binding site; other site
378806005876	PUA domain; Region: PUA; pfam01472
378806005877	Predicted transcriptional regulator [Transcription]; Region: COG2378
378806005878	WYL domain; Region: WYL; pfam13280
378806005879	WYL domain; Region: WYL; pfam13280
378806005880	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806005881	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806005882	phosphopeptide binding site; other site
378806005883	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
378806005884	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
378806005885	putative active site [active]
378806005886	catalytic site [active]
378806005887	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
378806005888	putative active site [active]
378806005889	catalytic site [active]
378806005890	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
378806005891	dinuclear metal binding motif [ion binding]; other site
378806005892	aconitate hydratase; Validated; Region: PRK09277
378806005893	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
378806005894	substrate binding site [chemical binding]; other site
378806005895	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
378806005896	ligand binding site [chemical binding]; other site
378806005897	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
378806005898	substrate binding site [chemical binding]; other site
378806005899	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
378806005900	Active site serine [active]
378806005901	HD domain; Region: HD_4; pfam13328
378806005902	hypothetical protein; Provisional; Region: PRK09256
378806005903	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
378806005904	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
378806005905	NAD binding site [chemical binding]; other site
378806005906	substrate binding site [chemical binding]; other site
378806005907	catalytic Zn binding site [ion binding]; other site
378806005908	structural Zn binding site [ion binding]; other site
378806005909	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
378806005910	active site
378806005911	catalytic residues [active]
378806005912	metal binding site [ion binding]; metal-binding site
378806005913	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806005914	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005915	active site
378806005916	ATP binding site [chemical binding]; other site
378806005917	substrate binding site [chemical binding]; other site
378806005918	activation loop (A-loop); other site
378806005919	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806005920	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806005921	structural tetrad; other site
378806005922	PQQ-like domain; Region: PQQ_2; pfam13360
378806005923	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806005924	structural tetrad; other site
378806005925	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806005926	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
378806005927	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
378806005928	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
378806005929	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806005930	active site
378806005931	HIGH motif; other site
378806005932	nucleotide binding site [chemical binding]; other site
378806005933	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
378806005934	KMSKS motif; other site
378806005935	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
378806005936	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
378806005937	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806005938	P-loop; other site
378806005939	Magnesium ion binding site [ion binding]; other site
378806005940	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806005941	Magnesium ion binding site [ion binding]; other site
378806005942	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
378806005943	PilZ domain; Region: PilZ; pfam07238
378806005944	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
378806005945	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
378806005946	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806005947	catalytic residue [active]
378806005948	Protein of unknown function (DUF819); Region: DUF819; cl02317
378806005949	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
378806005950	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806005951	Walker A/P-loop; other site
378806005952	ATP binding site [chemical binding]; other site
378806005953	Q-loop/lid; other site
378806005954	ABC transporter signature motif; other site
378806005955	Walker B; other site
378806005956	D-loop; other site
378806005957	H-loop/switch region; other site
378806005958	Response regulator receiver domain; Region: Response_reg; pfam00072
378806005959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806005960	active site
378806005961	phosphorylation site [posttranslational modification]
378806005962	intermolecular recognition site; other site
378806005963	dimerization interface [polypeptide binding]; other site
378806005964	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
378806005965	active site
378806005966	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
378806005967	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806005968	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
378806005969	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
378806005970	Substrate binding site; other site
378806005971	Mg++ binding site; other site
378806005972	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
378806005973	active site
378806005974	substrate binding site [chemical binding]; other site
378806005975	CoA binding site [chemical binding]; other site
378806005976	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
378806005977	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
378806005978	glutaminase active site [active]
378806005979	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
378806005980	dimer interface [polypeptide binding]; other site
378806005981	active site
378806005982	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
378806005983	dimer interface [polypeptide binding]; other site
378806005984	active site
378806005985	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806005986	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806005987	active site
378806005988	ATP binding site [chemical binding]; other site
378806005989	substrate binding site [chemical binding]; other site
378806005990	activation loop (A-loop); other site
378806005991	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
378806005992	Putative zinc-finger; Region: zf-HC2; pfam13490
378806005993	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
378806005994	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806005995	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806005996	DNA binding residues [nucleotide binding]
378806005997	recombinase A; Provisional; Region: recA; PRK09354
378806005998	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
378806005999	hexamer interface [polypeptide binding]; other site
378806006000	Walker A motif; other site
378806006001	ATP binding site [chemical binding]; other site
378806006002	Walker B motif; other site
378806006003	PhoD-like phosphatase; Region: PhoD; pfam09423
378806006004	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
378806006005	putative active site [active]
378806006006	putative metal binding site [ion binding]; other site
378806006007	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806006008	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
378806006009	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
378806006010	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
378806006011	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
378806006012	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
378806006013	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
378806006014	RNA binding site [nucleotide binding]; other site
378806006015	PAS fold; Region: PAS_4; pfam08448
378806006016	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806006017	PAS fold; Region: PAS_3; pfam08447
378806006018	putative active site [active]
378806006019	heme pocket [chemical binding]; other site
378806006020	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806006021	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806006022	dimer interface [polypeptide binding]; other site
378806006023	phosphorylation site [posttranslational modification]
378806006024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806006025	ATP binding site [chemical binding]; other site
378806006026	Mg2+ binding site [ion binding]; other site
378806006027	G-X-G motif; other site
378806006028	HSP90 family protein; Provisional; Region: PRK14083
378806006029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806006030	ATP binding site [chemical binding]; other site
378806006031	Mg2+ binding site [ion binding]; other site
378806006032	G-X-G motif; other site
378806006033	tellurium resistance terB-like protein; Region: terB_like; cl11965
378806006034	metal binding site [ion binding]; metal-binding site
378806006035	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
378806006036	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
378806006037	NAD(P) binding site [chemical binding]; other site
378806006038	catalytic residues [active]
378806006039	Protein of unknown function (DUF779); Region: DUF779; pfam05610
378806006040	HEAT repeats; Region: HEAT_2; pfam13646
378806006041	HEAT repeats; Region: HEAT_2; pfam13646
378806006042	HEAT repeats; Region: HEAT_2; pfam13646
378806006043	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
378806006044	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
378806006045	putative active site [active]
378806006046	substrate binding site [chemical binding]; other site
378806006047	putative cosubstrate binding site; other site
378806006048	catalytic site [active]
378806006049	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
378806006050	substrate binding site [chemical binding]; other site
378806006051	Dehydroquinase class II; Region: DHquinase_II; pfam01220
378806006052	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505
378806006053	trimer interface [polypeptide binding]; other site
378806006054	active site
378806006055	dimer interface [polypeptide binding]; other site
378806006056	16S rRNA methyltransferase B; Provisional; Region: PRK14902
378806006057	NusB family; Region: NusB; pfam01029
378806006058	putative RNA binding site [nucleotide binding]; other site
378806006059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806006060	S-adenosylmethionine binding site [chemical binding]; other site
378806006061	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
378806006062	iron-sulfur cluster [ion binding]; other site
378806006063	[2Fe-2S] cluster binding site [ion binding]; other site
378806006064	Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616
378806006065	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806006066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806006067	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
378806006068	dimerization interface [polypeptide binding]; other site
378806006069	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
378806006070	Dihydroneopterin aldolase; Region: FolB; pfam02152
378806006071	active site
378806006072	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
378806006073	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
378806006074	Sulfate transporter family; Region: Sulfate_transp; pfam00916
378806006075	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
378806006076	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
378806006077	active site clefts [active]
378806006078	zinc binding site [ion binding]; other site
378806006079	dimer interface [polypeptide binding]; other site
378806006080	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
378806006081	putative active site [active]
378806006082	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806006083	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806006084	active site
378806006085	ATP binding site [chemical binding]; other site
378806006086	substrate binding site [chemical binding]; other site
378806006087	activation loop (A-loop); other site
378806006088	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006089	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006091	binding surface
378806006092	TPR motif; other site
378806006093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006094	TPR motif; other site
378806006095	TPR repeat; Region: TPR_11; pfam13414
378806006096	binding surface
378806006097	XPC-binding domain; Region: XPC-binding; pfam09280
378806006098	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806006099	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
378806006100	NAD(P) binding site [chemical binding]; other site
378806006101	active site
378806006102	transaminase; Validated; Region: PRK07324
378806006103	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806006104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806006105	homodimer interface [polypeptide binding]; other site
378806006106	catalytic residue [active]
378806006107	DNA primase large subunit; Validated; Region: PRK02249
378806006108	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
378806006109	SnoaL-like domain; Region: SnoaL_2; pfam12680
378806006110	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806006111	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806006112	Domain of unknown function (DUF4215); Region: DUF4215; pfam13948
378806006113	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806006114	Domain of unknown function (DUF4215); Region: DUF4215; pfam13948
378806006115	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806006116	PA14 domain; Region: PA14; cl08459
378806006117	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806006118	dimerization interface [polypeptide binding]; other site
378806006119	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806006120	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806006121	dimer interface [polypeptide binding]; other site
378806006122	putative CheW interface [polypeptide binding]; other site
378806006123	FOG: WD40-like repeat [Function unknown]; Region: COG1520
378806006124	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806006125	classical (c) SDRs; Region: SDR_c; cd05233
378806006126	NAD(P) binding site [chemical binding]; other site
378806006127	active site
378806006128	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806006129	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806006130	active site
378806006131	Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258
378806006132	active site
378806006133	Zn binding site [ion binding]; other site
378806006134	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
378806006135	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806006136	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806006137	DNA binding residues [nucleotide binding]
378806006138	Putative zinc-finger; Region: zf-HC2; pfam13490
378806006139	CHAT domain; Region: CHAT; cl17868
378806006140	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
378806006141	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
378806006142	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
378806006143	putative active site [active]
378806006144	putative substrate binding site [chemical binding]; other site
378806006145	putative cosubstrate binding site; other site
378806006146	catalytic site [active]
378806006147	photolyase PhrII; Region: phr2; TIGR00591
378806006148	DNA photolyase; Region: DNA_photolyase; pfam00875
378806006149	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
378806006150	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806006151	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
378806006152	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
378806006153	active site
378806006154	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806006155	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
378806006156	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
378806006157	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
378806006158	Transcriptional regulators [Transcription]; Region: MarR; COG1846
378806006159	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
378806006160	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
378806006161	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806006162	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
378806006163	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806006164	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
378806006165	Transcriptional regulators [Transcription]; Region: MarR; COG1846
378806006166	MarR family; Region: MarR_2; pfam12802
378806006167	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806006168	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806006169	Domain of unknown function (DUF4215); Region: DUF4215; pfam13948
378806006170	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806006171	Domain of unknown function (DUF4215); Region: DUF4215; pfam13948
378806006172	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806006173	PA14 domain; Region: PA14; cl08459
378806006174	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806006175	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806006176	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
378806006177	putative effector binding pocket; other site
378806006178	dimerization interface [polypeptide binding]; other site
378806006179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806006180	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
378806006181	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806006182	active site
378806006183	tetratricopeptide repeat protein; Provisional; Region: PRK11788
378806006184	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
378806006185	ATP binding site [chemical binding]; other site
378806006186	G-X-G motif; other site
378806006187	primosome assembly protein PriA; Validated; Region: PRK05580
378806006188	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806006189	ATP binding site [chemical binding]; other site
378806006190	putative Mg++ binding site [ion binding]; other site
378806006191	helicase superfamily c-terminal domain; Region: HELICc; smart00490
378806006192	ATP-binding site [chemical binding]; other site
378806006193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806006194	active site
378806006195	phosphorylation site [posttranslational modification]
378806006196	intermolecular recognition site; other site
378806006197	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806006198	HSP70 interaction site [polypeptide binding]; other site
378806006199	Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719
378806006200	dimer interface [polypeptide binding]; other site
378806006201	metal binding sites [ion binding]; metal-binding site
378806006202	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
378806006203	active site
378806006204	catalytic residues [active]
378806006205	metal binding site [ion binding]; metal-binding site
378806006206	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
378806006207	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
378806006208	tetramer interface [polypeptide binding]; other site
378806006209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806006210	catalytic residue [active]
378806006211	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
378806006212	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806006213	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
378806006214	IHF dimer interface [polypeptide binding]; other site
378806006215	IHF - DNA interface [nucleotide binding]; other site
378806006216	Right handed beta helix region; Region: Beta_helix; pfam13229
378806006217	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
378806006218	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
378806006219	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
378806006220	competence damage-inducible protein A; Provisional; Region: PRK00549
378806006221	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
378806006222	putative MPT binding site; other site
378806006223	Competence-damaged protein; Region: CinA; pfam02464
378806006224	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
378806006225	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
378806006226	hexamer interface [polypeptide binding]; other site
378806006227	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
378806006228	Walker A motif; other site
378806006229	ATP binding site [chemical binding]; other site
378806006230	Walker B motif; other site
378806006231	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806006232	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
378806006233	putative acyl-acceptor binding pocket; other site
378806006234	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
378806006235	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
378806006236	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
378806006237	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
378806006238	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806006239	Walker A motif; other site
378806006240	ATP binding site [chemical binding]; other site
378806006241	Walker B motif; other site
378806006242	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
378806006243	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
378806006244	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
378806006245	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
378806006246	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806006247	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806006248	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806006249	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806006250	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
378806006251	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806006252	FeS/SAM binding site; other site
378806006253	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
378806006254	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
378806006255	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
378806006256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806006257	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
378806006258	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
378806006259	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
378806006260	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
378806006261	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
378806006262	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
378806006263	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
378806006264	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
378806006265	TPR repeat; Region: TPR_11; pfam13414
378806006266	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006267	binding surface
378806006268	TPR motif; other site
378806006269	TPR repeat; Region: TPR_11; pfam13414
378806006270	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
378806006271	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
378806006272	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
378806006273	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
378806006274	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
378806006275	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
378806006276	GatB domain; Region: GatB_Yqey; smart00845
378806006277	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
378806006278	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
378806006279	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
378806006280	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806006281	active site
378806006282	ATP binding site [chemical binding]; other site
378806006283	substrate binding site [chemical binding]; other site
378806006284	activation loop (A-loop); other site
378806006285	PilZ domain; Region: PilZ; pfam07238
378806006286	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
378806006287	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
378806006288	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
378806006289	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
378806006290	GTP1/OBG; Region: GTP1_OBG; pfam01018
378806006291	Obg GTPase; Region: Obg; cd01898
378806006292	G1 box; other site
378806006293	GTP/Mg2+ binding site [chemical binding]; other site
378806006294	Switch I region; other site
378806006295	G2 box; other site
378806006296	G3 box; other site
378806006297	Switch II region; other site
378806006298	G4 box; other site
378806006299	G5 box; other site
378806006300	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
378806006301	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
378806006302	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
378806006303	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806006304	putative catalytic site [active]
378806006305	putative metal binding site [ion binding]; other site
378806006306	putative phosphate binding site [ion binding]; other site
378806006307	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
378806006308	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
378806006309	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806006310	FeS/SAM binding site; other site
378806006311	TRAM domain; Region: TRAM; pfam01938
378806006312	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
378806006313	putative ligand binding site [chemical binding]; other site
378806006314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
378806006315	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
378806006316	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
378806006317	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806006318	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
378806006319	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
378806006320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806006321	Walker A motif; other site
378806006322	ATP binding site [chemical binding]; other site
378806006323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806006324	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806006325	Walker A motif; other site
378806006326	ATP binding site [chemical binding]; other site
378806006327	Walker B motif; other site
378806006328	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
378806006329	peptide chain release factor 2; Region: prfB; TIGR00020
378806006330	PCRF domain; Region: PCRF; cl17745
378806006331	Uncharacterized conserved protein [Function unknown]; Region: COG1359
378806006332	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
378806006333	Active_site [active]
378806006334	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
378806006335	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
378806006336	active site
378806006337	metal binding site [ion binding]; metal-binding site
378806006338	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806006339	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806006340	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
378806006341	CoenzymeA binding site [chemical binding]; other site
378806006342	subunit interaction site [polypeptide binding]; other site
378806006343	PHB binding site; other site
378806006344	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
378806006345	Part of AAA domain; Region: AAA_19; pfam13245
378806006346	Family description; Region: UvrD_C_2; pfam13538
378806006347	PQQ-like domain; Region: PQQ_2; pfam13360
378806006348	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
378806006349	Trp docking motif [polypeptide binding]; other site
378806006350	active site
378806006351	PQQ-like domain; Region: PQQ_2; pfam13360
378806006352	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
378806006353	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
378806006354	active site
378806006355	purine riboside binding site [chemical binding]; other site
378806006356	short chain dehydrogenase; Provisional; Region: PRK07062
378806006357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806006358	NAD(P) binding site [chemical binding]; other site
378806006359	active site
378806006360	MltA specific insert domain; Region: MltA; smart00925
378806006361	3D domain; Region: 3D; pfam06725
378806006362	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
378806006363	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806006364	dimerization interface [polypeptide binding]; other site
378806006365	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806006366	dimer interface [polypeptide binding]; other site
378806006367	phosphorylation site [posttranslational modification]
378806006368	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806006369	ATP binding site [chemical binding]; other site
378806006370	Mg2+ binding site [ion binding]; other site
378806006371	G-X-G motif; other site
378806006372	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
378806006373	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
378806006374	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
378806006375	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
378806006376	ligand binding site; other site
378806006377	oligomer interface; other site
378806006378	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
378806006379	dimer interface [polypeptide binding]; other site
378806006380	N-terminal domain interface [polypeptide binding]; other site
378806006381	sulfate 1 binding site; other site
378806006382	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806006383	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806006384	phosphopeptide binding site; other site
378806006385	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806006386	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806006387	metal binding site [ion binding]; metal-binding site
378806006388	active site
378806006389	I-site; other site
378806006390	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806006391	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
378806006392	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806006393	NAD(P) binding site [chemical binding]; other site
378806006394	active site
378806006395	fatty acyl-CoA reductase; Region: PLN02996
378806006396	Male sterility protein; Region: NAD_binding_4; pfam07993
378806006397	NAD(P) binding site [chemical binding]; other site
378806006398	active site
378806006399	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806006400	active site
378806006401	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071
378806006402	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
378806006403	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
378806006404	acyl-activating enzyme (AAE) consensus motif; other site
378806006405	putative AMP binding site [chemical binding]; other site
378806006406	putative active site [active]
378806006407	putative CoA binding site [chemical binding]; other site
378806006408	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
378806006409	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
378806006410	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806006411	putative acyl-acceptor binding pocket; other site
378806006412	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
378806006413	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
378806006414	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
378806006415	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806006416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806006417	NAD(P) binding site [chemical binding]; other site
378806006418	active site
378806006419	SWIB/MDM2 domain; Region: SWIB; pfam02201
378806006420	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
378806006421	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
378806006422	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
378806006423	active site
378806006424	catalytic site [active]
378806006425	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
378806006426	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
378806006427	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
378806006428	active site
378806006429	catalytic site [active]
378806006430	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
378806006431	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
378806006432	ferrochelatase; Reviewed; Region: hemH; PRK00035
378806006433	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
378806006434	C-terminal domain interface [polypeptide binding]; other site
378806006435	active site
378806006436	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
378806006437	active site
378806006438	N-terminal domain interface [polypeptide binding]; other site
378806006439	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
378806006440	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
378806006441	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
378806006442	putative hydrophobic ligand binding site [chemical binding]; other site
378806006443	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806006444	TIGR01777 family protein; Region: yfcH
378806006445	NAD(P) binding site [chemical binding]; other site
378806006446	active site
378806006447	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
378806006448	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806006449	Walker A/P-loop; other site
378806006450	ATP binding site [chemical binding]; other site
378806006451	Q-loop/lid; other site
378806006452	ABC transporter signature motif; other site
378806006453	Walker B; other site
378806006454	D-loop; other site
378806006455	H-loop/switch region; other site
378806006456	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
378806006457	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
378806006458	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
378806006459	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
378806006460	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
378806006461	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806006462	NlpC/P60 family; Region: NLPC_P60; cl17555
378806006463	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806006464	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806006465	non-specific DNA binding site [nucleotide binding]; other site
378806006466	salt bridge; other site
378806006467	sequence-specific DNA binding site [nucleotide binding]; other site
378806006468	enterobactin exporter EntS; Provisional; Region: PRK10489
378806006469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806006470	putative substrate translocation pore; other site
378806006471	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
378806006472	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806006473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806006474	active site
378806006475	phosphorylation site [posttranslational modification]
378806006476	intermolecular recognition site; other site
378806006477	dimerization interface [polypeptide binding]; other site
378806006478	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806006479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806006480	dimer interface [polypeptide binding]; other site
378806006481	phosphorylation site [posttranslational modification]
378806006482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806006483	ATP binding site [chemical binding]; other site
378806006484	Mg2+ binding site [ion binding]; other site
378806006485	G-X-G motif; other site
378806006486	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
378806006487	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
378806006488	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
378806006489	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
378806006490	[2Fe-2S] cluster binding site [ion binding]; other site
378806006491	Hemerythrin-like domain; Region: Hr-like; cd12108
378806006492	Fe binding site [ion binding]; other site
378806006493	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
378806006494	endonuclease III; Region: ENDO3c; smart00478
378806006495	minor groove reading motif; other site
378806006496	helix-hairpin-helix signature motif; other site
378806006497	substrate binding pocket [chemical binding]; other site
378806006498	active site
378806006499	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
378806006500	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
378806006501	NAD binding site [chemical binding]; other site
378806006502	catalytic Zn binding site [ion binding]; other site
378806006503	structural Zn binding site [ion binding]; other site
378806006504	muropeptide transporter; Reviewed; Region: ampG; PRK11902
378806006505	muropeptide transporter; Validated; Region: ampG; cl17669
378806006506	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
378806006507	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806006508	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806006509	homodimer interface [polypeptide binding]; other site
378806006510	catalytic residue [active]
378806006511	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
378806006512	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
378806006513	dimerization interface [polypeptide binding]; other site
378806006514	DPS ferroxidase diiron center [ion binding]; other site
378806006515	ion pore; other site
378806006516	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
378806006517	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
378806006518	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
378806006519	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
378806006520	dimer interface [polypeptide binding]; other site
378806006521	decamer (pentamer of dimers) interface [polypeptide binding]; other site
378806006522	catalytic triad [active]
378806006523	peroxidatic and resolving cysteines [active]
378806006524	GAF domain; Region: GAF_3; pfam13492
378806006525	GAF domain; Region: GAF_2; pfam13185
378806006526	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806006527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806006528	Walker A motif; other site
378806006529	ATP binding site [chemical binding]; other site
378806006530	Walker B motif; other site
378806006531	arginine finger; other site
378806006532	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
378806006533	SdiA-regulated; Region: SdiA-regulated; cd09971
378806006534	putative active site [active]
378806006535	PemK-like protein; Region: PemK; pfam02452
378806006536	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806006537	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806006538	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806006539	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806006540	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
378806006541	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806006542	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806006543	ligand binding site [chemical binding]; other site
378806006544	HYR domain; Region: HYR; pfam02494
378806006545	HYR domain; Region: HYR; pfam02494
378806006546	HYR domain; Region: HYR; pfam02494
378806006547	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
378806006548	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806006549	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806006550	catalytic residue [active]
378806006551	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
378806006552	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
378806006553	dimer interface [polypeptide binding]; other site
378806006554	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806006555	catalytic residue [active]
378806006556	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
378806006557	serine O-acetyltransferase; Region: cysE; TIGR01172
378806006558	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
378806006559	trimer interface [polypeptide binding]; other site
378806006560	active site
378806006561	substrate binding site [chemical binding]; other site
378806006562	CoA binding site [chemical binding]; other site
378806006563	AMP-binding domain protein; Validated; Region: PRK08315
378806006564	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
378806006565	acyl-activating enzyme (AAE) consensus motif; other site
378806006566	putative AMP binding site [chemical binding]; other site
378806006567	putative active site [active]
378806006568	putative CoA binding site [chemical binding]; other site
378806006569	Predicted membrane protein [Function unknown]; Region: COG1238
378806006570	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806006571	putative catalytic site [active]
378806006572	putative metal binding site [ion binding]; other site
378806006573	putative phosphate binding site [ion binding]; other site
378806006574	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
378806006575	Lamin Tail Domain; Region: LTD; pfam00932
378806006576	Peptidase family M49; Region: Peptidase_M49; pfam03571
378806006577	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
378806006578	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
378806006579	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
378806006580	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
378806006581	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
378806006582	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
378806006583	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
378806006584	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806006585	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
378806006586	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
378806006587	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
378806006588	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
378806006589	active site
378806006590	uracil binding [chemical binding]; other site
378806006591	Serine hydrolase; Region: Ser_hydrolase; cl17834
378806006592	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806006593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806006594	S-adenosylmethionine binding site [chemical binding]; other site
378806006595	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806006596	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
378806006597	putative NAD(P) binding site [chemical binding]; other site
378806006598	active site
378806006599	putative substrate binding site [chemical binding]; other site
378806006600	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806006601	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
378806006602	putative acyl-acceptor binding pocket; other site
378806006603	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
378806006604	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806006605	active site
378806006606	metal binding site [ion binding]; metal-binding site
378806006607	alpha-amylase; Region: PLN02361
378806006608	Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314
378806006609	active site
378806006610	Ca binding site [ion binding]; other site
378806006611	catalytic site [active]
378806006612	Alpha-amylase C-terminal beta-sheet domain; Region: Alpha-amyl_C2; pfam07821
378806006613	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
378806006614	Domain of unknown function DUF20; Region: UPF0118; pfam01594
378806006615	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806006616	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
378806006617	enoyl-CoA hydratase; Provisional; Region: PRK06563
378806006618	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806006619	substrate binding site [chemical binding]; other site
378806006620	oxyanion hole (OAH) forming residues; other site
378806006621	trimer interface [polypeptide binding]; other site
378806006622	MarR family; Region: MarR_2; pfam12802
378806006623	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
378806006624	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
378806006625	xylose isomerase; Provisional; Region: PRK05474
378806006626	xylose isomerase; Region: xylose_isom_A; TIGR02630
378806006627	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
378806006628	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806006629	putative NAD(P) binding site [chemical binding]; other site
378806006630	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806006631	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
378806006632	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806006633	sugar binding site [chemical binding]; other site
378806006634	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806006635	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806006636	active site
378806006637	ATP binding site [chemical binding]; other site
378806006638	substrate binding site [chemical binding]; other site
378806006639	activation loop (A-loop); other site
378806006640	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806006641	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
378806006642	putative C-terminal domain interface [polypeptide binding]; other site
378806006643	putative GSH binding site (G-site) [chemical binding]; other site
378806006644	putative dimer interface [polypeptide binding]; other site
378806006645	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
378806006646	N-terminal domain interface [polypeptide binding]; other site
378806006647	dimer interface [polypeptide binding]; other site
378806006648	substrate binding pocket (H-site) [chemical binding]; other site
378806006649	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806006650	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806006651	salt bridge; other site
378806006652	non-specific DNA binding site [nucleotide binding]; other site
378806006653	sequence-specific DNA binding site [nucleotide binding]; other site
378806006654	Family description; Region: VCBS; pfam13517
378806006655	Family description; Region: VCBS; pfam13517
378806006656	Family description; Region: VCBS; pfam13517
378806006657	Family description; Region: VCBS; pfam13517
378806006658	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806006659	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
378806006660	SnoaL-like domain; Region: SnoaL_2; pfam12680
378806006661	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806006662	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
378806006663	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
378806006664	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806006665	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806006666	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
378806006667	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
378806006668	putative NAD(P) binding site [chemical binding]; other site
378806006669	putative substrate binding site [chemical binding]; other site
378806006670	catalytic Zn binding site [ion binding]; other site
378806006671	structural Zn binding site [ion binding]; other site
378806006672	dimer interface [polypeptide binding]; other site
378806006673	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
378806006674	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
378806006675	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
378806006676	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806006677	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806006678	structural tetrad; other site
378806006679	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806006680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806006681	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806006682	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806006683	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806006684	hypothetical protein; Provisional; Region: PRK06834
378806006685	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806006686	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806006687	GAF domain; Region: GAF_2; pfam13185
378806006688	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806006689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806006690	dimer interface [polypeptide binding]; other site
378806006691	phosphorylation site [posttranslational modification]
378806006692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806006693	ATP binding site [chemical binding]; other site
378806006694	Mg2+ binding site [ion binding]; other site
378806006695	G-X-G motif; other site
378806006696	DDE superfamily endonuclease; Region: DDE_5; cl17874
378806006697	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
378806006698	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
378806006699	RibD C-terminal domain; Region: RibD_C; cl17279
378806006700	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806006701	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806006702	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
378806006703	putative effector binding pocket; other site
378806006704	putative dimerization interface [polypeptide binding]; other site
378806006705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806006706	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
378806006707	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
378806006708	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
378806006709	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
378806006710	catalytic residues [active]
378806006711	catalytic nucleophile [active]
378806006712	Recombinase; Region: Recombinase; pfam07508
378806006713	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
378806006714	active site
378806006715	NTP binding site [chemical binding]; other site
378806006716	metal binding triad [ion binding]; metal-binding site
378806006717	ThiF family; Region: ThiF; pfam00899
378806006718	ATP binding site [chemical binding]; other site
378806006719	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
378806006720	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
378806006721	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133
378806006722	PLD-like domain; Region: PLDc_2; pfam13091
378806006723	putative active site [active]
378806006724	putative catalytic site [active]
378806006725	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133
378806006726	PLD-like domain; Region: PLDc_2; pfam13091
378806006727	putative active site [active]
378806006728	putative catalytic site [active]
378806006729	AAA domain; Region: AAA_11; pfam13086
378806006730	Part of AAA domain; Region: AAA_19; pfam13245
378806006731	AAA domain; Region: AAA_12; pfam13087
378806006732	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806006733	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806006734	Transposase domain (DUF772); Region: DUF772; pfam05598
378806006735	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806006736	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
378806006737	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
378806006738	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806006739	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806006740	active site
378806006741	ATP binding site [chemical binding]; other site
378806006742	substrate binding site [chemical binding]; other site
378806006743	activation loop (A-loop); other site
378806006744	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806006745	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806006746	active site
378806006747	ATP binding site [chemical binding]; other site
378806006748	substrate binding site [chemical binding]; other site
378806006749	activation loop (A-loop); other site
378806006750	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806006751	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
378806006752	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
378806006753	DDE superfamily endonuclease; Region: DDE_5; pfam13546
378806006754	Domain of unknown function (DUF4417); Region: DUF4417; pfam14386
378806006755	amidase, hydantoinase/carbamoylase family; Region: hydantase; TIGR01879
378806006756	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
378806006757	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
378806006758	cofactor binding site; other site
378806006759	DNA binding site [nucleotide binding]
378806006760	substrate interaction site [chemical binding]; other site
378806006761	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
378806006762	Z1 domain; Region: Z1; pfam10593
378806006763	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
378806006764	ATP binding site [chemical binding]; other site
378806006765	Mg2+ binding site [ion binding]; other site
378806006766	G-X-G motif; other site
378806006767	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
378806006768	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
378806006769	Part of AAA domain; Region: AAA_19; pfam13245
378806006770	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
378806006771	AAA domain; Region: AAA_12; pfam13087
378806006772	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806006773	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806006774	active site
378806006775	ATP binding site [chemical binding]; other site
378806006776	substrate binding site [chemical binding]; other site
378806006777	activation loop (A-loop); other site
378806006778	Protein phosphatase 2C; Region: PP2C_2; pfam13672
378806006779	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
378806006780	metal ion-dependent adhesion site (MIDAS); other site
378806006781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806006782	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806006783	Walker A motif; other site
378806006784	ATP binding site [chemical binding]; other site
378806006785	Walker B motif; other site
378806006786	arginine finger; other site
378806006787	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
378806006788	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
378806006789	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
378806006790	catalytic residues [active]
378806006791	catalytic nucleophile [active]
378806006792	Presynaptic Site I dimer interface [polypeptide binding]; other site
378806006793	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
378806006794	Synaptic Flat tetramer interface [polypeptide binding]; other site
378806006795	Synaptic Site I dimer interface [polypeptide binding]; other site
378806006796	DNA binding site [nucleotide binding]
378806006797	Recombinase; Region: Recombinase; pfam07508
378806006798	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
378806006799	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806006800	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806006801	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806006802	active site
378806006803	ATP binding site [chemical binding]; other site
378806006804	substrate binding site [chemical binding]; other site
378806006805	activation loop (A-loop); other site
378806006806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806006807	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806006808	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806006809	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806006810	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
378806006811	Transposase domain (DUF772); Region: DUF772; pfam05598
378806006812	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006813	binding surface
378806006814	TPR motif; other site
378806006815	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006816	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006817	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006818	TPR motif; other site
378806006819	binding surface
378806006820	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006821	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006822	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006823	TPR motif; other site
378806006824	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006825	binding surface
378806006826	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006827	TPR motif; other site
378806006828	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006829	binding surface
378806006830	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006831	Tetratricopeptide repeat; Region: TPR_10; pfam13374
378806006832	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006834	binding surface
378806006835	TPR motif; other site
378806006836	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006837	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006839	TPR motif; other site
378806006840	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006841	binding surface
378806006842	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006844	binding surface
378806006845	TPR motif; other site
378806006846	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806006848	binding surface
378806006849	TPR motif; other site
378806006850	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806006851	CHAT domain; Region: CHAT; pfam12770
378806006852	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
378806006853	DDE superfamily endonuclease; Region: DDE_3; pfam13358
378806006854	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
378806006855	TIR domain; Region: TIR_2; pfam13676
378806006856	AAA ATPase domain; Region: AAA_16; pfam13191
378806006857	NACHT domain; Region: NACHT; pfam05729
378806006858	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
378806006859	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806006860	phage tail protein domain; Region: tail_TIGR02242
378806006861	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
378806006862	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
378806006863	DNA binding residues [nucleotide binding]
378806006864	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
378806006865	active site
378806006866	HNH endonuclease; Region: HNH_3; pfam13392
378806006867	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
378806006868	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
378806006869	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
378806006870	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
378806006871	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
378806006872	Protein of unknown function DUF262; Region: DUF262; pfam03235
378806006873	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
378806006874	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
378806006875	putative active site [active]
378806006876	putative NTP binding site [chemical binding]; other site
378806006877	putative nucleic acid binding site [nucleotide binding]; other site
378806006878	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
378806006879	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
378806006880	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
378806006881	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
378806006882	Phage capsid family; Region: Phage_capsid; pfam05065
378806006883	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
378806006884	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
378806006885	Phage-related protein [Function unknown]; Region: COG4695; cl01923
378806006886	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
378806006887	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
378806006888	active site
378806006889	catalytic triad [active]
378806006890	oxyanion hole [active]
378806006891	potential frameshift: common BLAST hit: gi|262194298|ref|YP_003265507.1| protein of unknown function DUF264
378806006892	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
378806006893	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
378806006894	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806006895	active site
378806006896	DNA binding site [nucleotide binding]
378806006897	Int/Topo IB signature motif; other site
378806006898	Src Homology 3 domain superfamily; Region: SH3; cl17036
378806006899	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
378806006900	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
378806006901	active site
378806006902	catalytic site [active]
378806006903	substrate binding site [chemical binding]; other site
378806006904	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
378806006905	DEAD-like helicases superfamily; Region: DEXDc; smart00487
378806006906	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806006907	ATP binding site [chemical binding]; other site
378806006908	putative Mg++ binding site [ion binding]; other site
378806006909	nucleotide binding region [chemical binding]; other site
378806006910	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
378806006911	ATP-binding site [chemical binding]; other site
378806006912	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
378806006913	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
378806006914	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
378806006915	catalytic residues [active]
378806006916	catalytic nucleophile [active]
378806006917	Presynaptic Site I dimer interface [polypeptide binding]; other site
378806006918	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
378806006919	Synaptic Flat tetramer interface [polypeptide binding]; other site
378806006920	Synaptic Site I dimer interface [polypeptide binding]; other site
378806006921	DNA binding site [nucleotide binding]
378806006922	Recombinase; Region: Recombinase; pfam07508
378806006923	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
378806006924	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806006925	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806006926	active site
378806006927	ATP binding site [chemical binding]; other site
378806006928	substrate binding site [chemical binding]; other site
378806006929	activation loop (A-loop); other site
378806006930	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806006931	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806006932	non-specific DNA binding site [nucleotide binding]; other site
378806006933	salt bridge; other site
378806006934	sequence-specific DNA binding site [nucleotide binding]; other site
378806006935	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806006936	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806006937	sequence-specific DNA binding site [nucleotide binding]; other site
378806006938	salt bridge; other site
378806006939	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806006940	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806006941	active site
378806006942	ATP binding site [chemical binding]; other site
378806006943	substrate binding site [chemical binding]; other site
378806006944	activation loop (A-loop); other site
378806006945	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806006946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806006947	Coenzyme A binding pocket [chemical binding]; other site
378806006948	AAA domain; Region: AAA_22; pfam13401
378806006949	HNH endonuclease; Region: HNH_5; pfam14279
378806006950	RDD family; Region: RDD; pfam06271
378806006951	HEAT repeats; Region: HEAT_2; pfam13646
378806006952	HEAT repeats; Region: HEAT_2; pfam13646
378806006953	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
378806006954	putative active site pocket [active]
378806006955	dimerization interface [polypeptide binding]; other site
378806006956	putative catalytic residue [active]
378806006957	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
378806006958	putative active site pocket [active]
378806006959	dimerization interface [polypeptide binding]; other site
378806006960	putative catalytic residue [active]
378806006961	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
378806006962	phage tail protein domain; Region: tail_TIGR02242
378806006963	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
378806006964	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
378806006965	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
378806006966	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
378806006967	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
378806006968	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
378806006969	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
378806006970	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
378806006971	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
378806006972	putative active site [active]
378806006973	putative NTP binding site [chemical binding]; other site
378806006974	putative nucleic acid binding site [nucleotide binding]; other site
378806006975	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
378806006976	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
378806006977	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
378806006978	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
378806006979	Phage capsid family; Region: Phage_capsid; pfam05065
378806006980	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
378806006981	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
378806006982	Phage-related protein [Function unknown]; Region: COG4695; cl01923
378806006983	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806006984	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806006985	non-specific DNA binding site [nucleotide binding]; other site
378806006986	salt bridge; other site
378806006987	sequence-specific DNA binding site [nucleotide binding]; other site
378806006988	Domain of unknown function (DUF955); Region: DUF955; cl01076
378806006989	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
378806006990	NADH dehydrogenase; Region: NADHdh; cl00469
378806006991	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
378806006992	large terminase protein; Provisional; Region: 17; PHA02533
378806006993	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806006994	active site
378806006995	DNA binding site [nucleotide binding]
378806006996	Int/Topo IB signature motif; other site
378806006997	HNH endonuclease; Region: HNH_3; pfam13392
378806006998	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
378806006999	DNA-binding interface [nucleotide binding]; DNA binding site
378806007000	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
378806007001	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
378806007002	active site
378806007003	catalytic site [active]
378806007004	substrate binding site [chemical binding]; other site
378806007005	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
378806007006	DEAD-like helicases superfamily; Region: DEXDc; smart00487
378806007007	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806007008	ATP binding site [chemical binding]; other site
378806007009	putative Mg++ binding site [ion binding]; other site
378806007010	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806007011	nucleotide binding region [chemical binding]; other site
378806007012	ATP-binding site [chemical binding]; other site
378806007013	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
378806007014	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
378806007015	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
378806007016	catalytic residues [active]
378806007017	catalytic nucleophile [active]
378806007018	Presynaptic Site I dimer interface [polypeptide binding]; other site
378806007019	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
378806007020	Synaptic Flat tetramer interface [polypeptide binding]; other site
378806007021	Synaptic Site I dimer interface [polypeptide binding]; other site
378806007022	DNA binding site [nucleotide binding]
378806007023	Recombinase; Region: Recombinase; pfam07508
378806007024	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
378806007025	DNA topoisomerase 2; Provisional; Region: PLN03237
378806007026	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806007027	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806007028	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806007029	active site
378806007030	ATP binding site [chemical binding]; other site
378806007031	substrate binding site [chemical binding]; other site
378806007032	activation loop (A-loop); other site
378806007033	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806007034	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806007035	non-specific DNA binding site [nucleotide binding]; other site
378806007036	salt bridge; other site
378806007037	sequence-specific DNA binding site [nucleotide binding]; other site
378806007038	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806007039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806007040	non-specific DNA binding site [nucleotide binding]; other site
378806007041	salt bridge; other site
378806007042	sequence-specific DNA binding site [nucleotide binding]; other site
378806007043	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806007044	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806007045	active site
378806007046	ATP binding site [chemical binding]; other site
378806007047	substrate binding site [chemical binding]; other site
378806007048	activation loop (A-loop); other site
378806007049	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806007050	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
378806007051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806007052	S-adenosylmethionine binding site [chemical binding]; other site
378806007053	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
378806007054	dimer interface [polypeptide binding]; other site
378806007055	catalytic triad [active]
378806007056	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806007057	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806007058	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
378806007059	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
378806007060	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
378806007061	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
378806007062	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
378806007063	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806007064	catalytic residues [active]
378806007065	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
378806007066	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
378806007067	active site
378806007068	dimerization interface [polypeptide binding]; other site
378806007069	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
378806007070	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
378806007071	SLBB domain; Region: SLBB; pfam10531
378806007072	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
378806007073	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806007074	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007075	binding surface
378806007076	TPR motif; other site
378806007077	TPR repeat; Region: TPR_11; pfam13414
378806007078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007079	TPR motif; other site
378806007080	binding surface
378806007081	TPR repeat; Region: TPR_11; pfam13414
378806007082	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
378806007083	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
378806007084	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007085	binding surface
378806007086	TPR motif; other site
378806007087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007088	binding surface
378806007089	TPR motif; other site
378806007090	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
378806007091	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
378806007092	G1 box; other site
378806007093	GTP/Mg2+ binding site [chemical binding]; other site
378806007094	G2 box; other site
378806007095	Switch I region; other site
378806007096	G3 box; other site
378806007097	Switch II region; other site
378806007098	G4 box; other site
378806007099	G5 box; other site
378806007100	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
378806007101	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
378806007102	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806007103	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806007104	FecR protein; Region: FecR; pfam04773
378806007105	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806007106	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806007107	active site
378806007108	ATP binding site [chemical binding]; other site
378806007109	substrate binding site [chemical binding]; other site
378806007110	activation loop (A-loop); other site
378806007111	recombination protein RecR; Reviewed; Region: recR; PRK00076
378806007112	RecR protein; Region: RecR; pfam02132
378806007113	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
378806007114	putative active site [active]
378806007115	putative metal-binding site [ion binding]; other site
378806007116	tetramer interface [polypeptide binding]; other site
378806007117	hypothetical protein; Validated; Region: PRK00153
378806007118	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
378806007119	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
378806007120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806007121	Walker A motif; other site
378806007122	ATP binding site [chemical binding]; other site
378806007123	Walker B motif; other site
378806007124	arginine finger; other site
378806007125	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
378806007126	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
378806007127	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806007128	Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751
378806007129	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
378806007130	nucleoside/Zn binding site; other site
378806007131	dimer interface [polypeptide binding]; other site
378806007132	catalytic motif [active]
378806007133	seryl-tRNA synthetase; Provisional; Region: PRK05431
378806007134	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
378806007135	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
378806007136	dimer interface [polypeptide binding]; other site
378806007137	active site
378806007138	motif 1; other site
378806007139	motif 2; other site
378806007140	motif 3; other site
378806007141	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
378806007142	TPR repeat; Region: TPR_11; pfam13414
378806007143	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007144	binding surface
378806007145	TPR motif; other site
378806007146	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007147	binding surface
378806007148	TPR motif; other site
378806007149	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007150	TPR motif; other site
378806007151	binding surface
378806007152	TPR repeat; Region: TPR_11; pfam13414
378806007153	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007154	binding surface
378806007155	TPR motif; other site
378806007156	TPR repeat; Region: TPR_11; pfam13414
378806007157	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007158	TPR motif; other site
378806007159	binding surface
378806007160	TPR repeat; Region: TPR_11; pfam13414
378806007161	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
378806007162	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806007163	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
378806007164	Ligand binding site; other site
378806007165	Putative Catalytic site; other site
378806007166	DXD motif; other site
378806007167	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
378806007168	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806007169	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
378806007170	putative acyl-acceptor binding pocket; other site
378806007171	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
378806007172	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806007173	putative NAD(P) binding site [chemical binding]; other site
378806007174	active site
378806007175	putative substrate binding site [chemical binding]; other site
378806007176	TPR repeat; Region: TPR_11; pfam13414
378806007177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007178	binding surface
378806007179	TPR motif; other site
378806007180	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806007181	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007182	TPR motif; other site
378806007183	binding surface
378806007184	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
378806007185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007186	binding surface
378806007187	TPR motif; other site
378806007188	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007189	TPR repeat; Region: TPR_11; pfam13414
378806007190	binding surface
378806007191	TPR motif; other site
378806007192	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007193	TPR repeat; Region: TPR_11; pfam13414
378806007194	binding surface
378806007195	TPR motif; other site
378806007196	DEAD-like helicases superfamily; Region: DEXDc; smart00487
378806007197	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
378806007198	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806007199	ATP binding site [chemical binding]; other site
378806007200	putative Mg++ binding site [ion binding]; other site
378806007201	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
378806007202	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806007203	nucleotide binding region [chemical binding]; other site
378806007204	ATP-binding site [chemical binding]; other site
378806007205	HRDC domain; Region: HRDC; pfam00570
378806007206	hypothetical protein; Reviewed; Region: PRK00024
378806007207	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
378806007208	MPN+ (JAMM) motif; other site
378806007209	Zinc-binding site [ion binding]; other site
378806007210	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
378806007211	NAD-dependent deacetylase; Provisional; Region: PRK05333
378806007212	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
378806007213	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
378806007214	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
378806007215	NAD binding site [chemical binding]; other site
378806007216	catalytic residues [active]
378806007217	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
378806007218	homotrimer interaction site [polypeptide binding]; other site
378806007219	putative active site [active]
378806007220	3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399
378806007221	Amidohydrolase; Region: Amidohydro_2; pfam04909
378806007222	active site
378806007223	kynureninase; Region: kynureninase; TIGR01814
378806007224	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806007225	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806007226	catalytic residue [active]
378806007227	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
378806007228	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806007229	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
378806007230	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806007231	putative NAD(P) binding site [chemical binding]; other site
378806007232	putative active site [active]
378806007233	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
378806007234	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
378806007235	putative active site [active]
378806007236	putative active site [active]
378806007237	catalytic site [active]
378806007238	catalytic site [active]
378806007239	DEAD-like helicases superfamily; Region: DEXDc; smart00487
378806007240	DEAD/DEAH box helicase; Region: DEAD; pfam00270
378806007241	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
378806007242	putative Mg++ binding site [ion binding]; other site
378806007243	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806007244	ATP-binding site [chemical binding]; other site
378806007245	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
378806007246	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806007247	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806007248	DNA-binding site [nucleotide binding]; DNA binding site
378806007249	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806007250	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
378806007251	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
378806007252	putative NAD(P) binding site [chemical binding]; other site
378806007253	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
378806007254	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806007255	NAD(P) binding site [chemical binding]; other site
378806007256	active site
378806007257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806007258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806007259	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
378806007260	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
378806007261	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
378806007262	dimer interface [polypeptide binding]; other site
378806007263	active site
378806007264	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
378806007265	heme binding pocket [chemical binding]; other site
378806007266	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806007267	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
378806007268	Di-iron ligands [ion binding]; other site
378806007269	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
378806007270	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
378806007271	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
378806007272	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
378806007273	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
378806007274	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
378806007275	conserved cys residue [active]
378806007276	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
378806007277	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
378806007278	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806007279	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806007280	active site
378806007281	ATP binding site [chemical binding]; other site
378806007282	substrate binding site [chemical binding]; other site
378806007283	activation loop (A-loop); other site
378806007284	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
378806007285	PAS fold; Region: PAS_4; pfam08448
378806007286	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806007287	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806007288	putative active site [active]
378806007289	heme pocket [chemical binding]; other site
378806007290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806007291	dimer interface [polypeptide binding]; other site
378806007292	phosphorylation site [posttranslational modification]
378806007293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806007294	ATP binding site [chemical binding]; other site
378806007295	Mg2+ binding site [ion binding]; other site
378806007296	G-X-G motif; other site
378806007297	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
378806007298	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
378806007299	CAAX protease self-immunity; Region: Abi; pfam02517
378806007300	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
378806007301	putative deacylase active site [active]
378806007302	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
378806007303	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806007304	transaminase, acetylornithine/succinylornithine family; Region: argD; TIGR00707
378806007305	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806007306	catalytic residue [active]
378806007307	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
378806007308	active site
378806007309	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
378806007310	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
378806007311	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
378806007312	dimer interface [polypeptide binding]; other site
378806007313	active site
378806007314	AMP-binding enzyme; Region: AMP-binding; pfam00501
378806007315	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806007316	acyl-activating enzyme (AAE) consensus motif; other site
378806007317	active site
378806007318	AMP binding site [chemical binding]; other site
378806007319	CoA binding site [chemical binding]; other site
378806007320	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806007321	short chain dehydrogenase; Provisional; Region: PRK07577
378806007322	classical (c) SDRs; Region: SDR_c; cd05233
378806007323	NAD(P) binding site [chemical binding]; other site
378806007324	active site
378806007325	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806007326	Interdomain contacts; other site
378806007327	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806007328	sugar binding site [chemical binding]; other site
378806007329	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806007330	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806007331	calcium binding site 2 [ion binding]; other site
378806007332	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806007333	active site
378806007334	catalytic triad [active]
378806007335	calcium binding site 1 [ion binding]; other site
378806007336	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806007337	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806007338	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806007339	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806007340	ligand binding site [chemical binding]; other site
378806007341	flexible hinge region; other site
378806007342	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
378806007343	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
378806007344	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
378806007345	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
378806007346	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
378806007347	homodimer interface [polypeptide binding]; other site
378806007348	substrate-cofactor binding pocket; other site
378806007349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806007350	catalytic residue [active]
378806007351	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
378806007352	trimer interface [polypeptide binding]; other site
378806007353	dimer interface [polypeptide binding]; other site
378806007354	putative active site [active]
378806007355	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
378806007356	dimer interface [polypeptide binding]; other site
378806007357	ADP-ribose binding site [chemical binding]; other site
378806007358	active site
378806007359	nudix motif; other site
378806007360	metal binding site [ion binding]; metal-binding site
378806007361	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
378806007362	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
378806007363	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
378806007364	CoA binding domain; Region: CoA_binding; cl17356
378806007365	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
378806007366	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
378806007367	active site
378806007368	nucleophile elbow; other site
378806007369	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806007370	dimerization interface [polypeptide binding]; other site
378806007371	putative DNA binding site [nucleotide binding]; other site
378806007372	putative Zn2+ binding site [ion binding]; other site
378806007373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806007374	S-adenosylmethionine binding site [chemical binding]; other site
378806007375	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
378806007376	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
378806007377	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
378806007378	substrate binding pocket [chemical binding]; other site
378806007379	dimer interface [polypeptide binding]; other site
378806007380	inhibitor binding site; inhibition site
378806007381	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
378806007382	B12 binding site [chemical binding]; other site
378806007383	cobalt ligand [ion binding]; other site
378806007384	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
378806007385	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
378806007386	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
378806007387	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
378806007388	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
378806007389	minor groove reading motif; other site
378806007390	helix-hairpin-helix signature motif; other site
378806007391	substrate binding pocket [chemical binding]; other site
378806007392	active site
378806007393	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
378806007394	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
378806007395	DNA binding and oxoG recognition site [nucleotide binding]
378806007396	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806007397	Walker A/P-loop; other site
378806007398	ATP binding site [chemical binding]; other site
378806007399	AAA domain; Region: AAA_21; pfam13304
378806007400	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
378806007401	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
378806007402	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
378806007403	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
378806007404	putative ATP binding site [chemical binding]; other site
378806007405	putative substrate interface [chemical binding]; other site
378806007406	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
378806007407	active site
378806007408	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
378806007409	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
378806007410	Maf-like protein; Region: Maf; pfam02545
378806007411	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
378806007412	active site
378806007413	dimer interface [polypeptide binding]; other site
378806007414	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806007415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007416	TPR motif; other site
378806007417	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007418	TPR motif; other site
378806007419	binding surface
378806007420	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
378806007421	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
378806007422	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
378806007423	putative RNA binding site [nucleotide binding]; other site
378806007424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806007425	S-adenosylmethionine binding site [chemical binding]; other site
378806007426	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
378806007427	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
378806007428	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
378806007429	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
378806007430	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806007431	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
378806007432	Part of AAA domain; Region: AAA_19; pfam13245
378806007433	Family description; Region: UvrD_C_2; pfam13538
378806007434	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
378806007435	23S rRNA interface [nucleotide binding]; other site
378806007436	L3 interface [polypeptide binding]; other site
378806007437	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
378806007438	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
378806007439	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806007440	ATP binding site [chemical binding]; other site
378806007441	Walker B motif; other site
378806007442	recombination regulator RecX; Reviewed; Region: recX; PRK00117
378806007443	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
378806007444	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007445	binding surface
378806007446	TPR repeat; Region: TPR_11; pfam13414
378806007447	TPR motif; other site
378806007448	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806007449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007450	binding surface
378806007451	TPR motif; other site
378806007452	TPR repeat; Region: TPR_11; pfam13414
378806007453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806007454	binding surface
378806007455	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806007456	TPR motif; other site
378806007457	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806007458	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806007459	phosphopeptide binding site; other site
378806007460	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806007461	selenophosphate synthetase; Provisional; Region: PRK00943
378806007462	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
378806007463	dimerization interface [polypeptide binding]; other site
378806007464	putative ATP binding site [chemical binding]; other site
378806007465	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
378806007466	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
378806007467	active site
378806007468	metal binding site [ion binding]; metal-binding site
378806007469	ribonuclease PH; Reviewed; Region: rph; PRK00173
378806007470	Ribonuclease PH; Region: RNase_PH_bact; cd11362
378806007471	hexamer interface [polypeptide binding]; other site
378806007472	active site
378806007473	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
378806007474	active site
378806007475	dimerization interface [polypeptide binding]; other site
378806007476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806007477	PAS fold; Region: PAS_3; pfam08447
378806007478	putative active site [active]
378806007479	heme pocket [chemical binding]; other site
378806007480	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806007481	dimer interface [polypeptide binding]; other site
378806007482	phosphorylation site [posttranslational modification]
378806007483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806007484	ATP binding site [chemical binding]; other site
378806007485	Mg2+ binding site [ion binding]; other site
378806007486	G-X-G motif; other site
378806007487	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
378806007488	heme-binding residues [chemical binding]; other site
378806007489	Ceramidase; Region: Ceramidase; pfam05875
378806007490	RecT family; Region: RecT; pfam03837
378806007491	trigger factor; Region: tig; TIGR00115
378806007492	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
378806007493	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
378806007494	Clp protease; Region: CLP_protease; pfam00574
378806007495	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
378806007496	oligomer interface [polypeptide binding]; other site
378806007497	active site residues [active]
378806007498	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
378806007499	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
378806007500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806007501	Walker A motif; other site
378806007502	ATP binding site [chemical binding]; other site
378806007503	Walker B motif; other site
378806007504	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
378806007505	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
378806007506	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806007507	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
378806007508	Found in ATP-dependent protease La (LON); Region: LON; smart00464
378806007509	Found in ATP-dependent protease La (LON); Region: LON; smart00464
378806007510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806007511	Walker A motif; other site
378806007512	ATP binding site [chemical binding]; other site
378806007513	Walker B motif; other site
378806007514	arginine finger; other site
378806007515	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
378806007516	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
378806007517	peptide binding site [polypeptide binding]; other site
378806007518	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
378806007519	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
378806007520	dimer interface [polypeptide binding]; other site
378806007521	conserved gate region; other site
378806007522	putative PBP binding loops; other site
378806007523	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
378806007524	ABC-ATPase subunit interface; other site
378806007525	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
378806007526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806007527	dimer interface [polypeptide binding]; other site
378806007528	conserved gate region; other site
378806007529	putative PBP binding loops; other site
378806007530	ABC-ATPase subunit interface; other site
378806007531	Response regulator receiver domain; Region: Response_reg; pfam00072
378806007532	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806007533	active site
378806007534	phosphorylation site [posttranslational modification]
378806007535	intermolecular recognition site; other site
378806007536	dimerization interface [polypeptide binding]; other site
378806007537	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
378806007538	BolA-like protein; Region: BolA; pfam01722
378806007539	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
378806007540	putative GSH binding site [chemical binding]; other site
378806007541	catalytic residues [active]
378806007542	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
378806007543	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
378806007544	active site
378806007545	nucleophile elbow; other site
378806007546	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
378806007547	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
378806007548	MOSC domain; Region: MOSC; pfam03473
378806007549	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
378806007550	proline aminopeptidase P II; Provisional; Region: PRK10879
378806007551	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
378806007552	active site
378806007553	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
378806007554	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
378806007555	active site
378806007556	catalytic residues [active]
378806007557	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
378806007558	Phage Tail Collar Domain; Region: Collar; pfam07484
378806007559	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806007560	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806007561	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806007562	active site
378806007563	ATP binding site [chemical binding]; other site
378806007564	substrate binding site [chemical binding]; other site
378806007565	activation loop (A-loop); other site
378806007566	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806007567	active site
378806007568	ATP binding site [chemical binding]; other site
378806007569	substrate binding site [chemical binding]; other site
378806007570	activation loop (A-loop); other site
378806007571	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
378806007572	trimer interface [polypeptide binding]; other site
378806007573	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
378806007574	basic region leucin zipper; Region: BRLZ; smart00338
378806007575	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
378806007576	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
378806007577	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806007578	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806007579	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806007580	active site
378806007581	catalytic tetrad [active]
378806007582	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806007583	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806007584	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806007585	potential frameshift: common BLAST hit: gi|51893224|ref|YP_075915.1| transposase
378806007586	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
378806007587	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806007588	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
378806007589	Chitin binding domain; Region: Chitin_bind_3; pfam03067
378806007590	Cellulose binding domain; Region: CBM_2; cl17741
378806007591	Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297
378806007592	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
378806007593	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806007594	Interdomain contacts; other site
378806007595	Cytokine receptor motif; other site
378806007596	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806007597	Cellulose binding domain; Region: CBM_3; pfam00942
378806007598	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
378806007599	Beta/Gamma crystallin; Region: Crystall; cl02528
378806007600	Beta/Gamma crystallin; Region: Crystall; cl02528
378806007601	DTW domain; Region: DTW; cl01221
378806007602	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
378806007603	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574
378806007604	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
378806007605	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806007606	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806007607	putative active site [active]
378806007608	heme pocket [chemical binding]; other site
378806007609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806007610	dimer interface [polypeptide binding]; other site
378806007611	phosphorylation site [posttranslational modification]
378806007612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806007613	ATP binding site [chemical binding]; other site
378806007614	G-X-G motif; other site
378806007615	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806007616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806007617	active site
378806007618	phosphorylation site [posttranslational modification]
378806007619	intermolecular recognition site; other site
378806007620	dimerization interface [polypeptide binding]; other site
378806007621	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
378806007622	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806007623	RNA binding surface [nucleotide binding]; other site
378806007624	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806007625	active site
378806007626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806007627	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
378806007628	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806007629	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806007630	calcium binding site 2 [ion binding]; other site
378806007631	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806007632	active site
378806007633	catalytic triad [active]
378806007634	calcium binding site 1 [ion binding]; other site
378806007635	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806007636	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
378806007637	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
378806007638	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
378806007639	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
378806007640	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
378806007641	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
378806007642	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806007643	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806007644	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
378806007645	active site clefts [active]
378806007646	zinc binding site [ion binding]; other site
378806007647	dimer interface [polypeptide binding]; other site
378806007648	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
378806007649	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
378806007650	substrate binding pocket [chemical binding]; other site
378806007651	membrane-bound complex binding site; other site
378806007652	hinge residues; other site
378806007653	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
378806007654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806007655	dimer interface [polypeptide binding]; other site
378806007656	conserved gate region; other site
378806007657	ABC-ATPase subunit interface; other site
378806007658	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
378806007659	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806007660	Walker A/P-loop; other site
378806007661	ATP binding site [chemical binding]; other site
378806007662	Q-loop/lid; other site
378806007663	ABC transporter signature motif; other site
378806007664	Walker B; other site
378806007665	D-loop; other site
378806007666	H-loop/switch region; other site
378806007667	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
378806007668	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806007669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806007670	homodimer interface [polypeptide binding]; other site
378806007671	catalytic residue [active]
378806007672	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
378806007673	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806007674	putative DNA binding site [nucleotide binding]; other site
378806007675	putative Zn2+ binding site [ion binding]; other site
378806007676	AsnC family; Region: AsnC_trans_reg; pfam01037
378806007677	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
378806007678	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806007679	substrate binding site [chemical binding]; other site
378806007680	oxyanion hole (OAH) forming residues; other site
378806007681	trimer interface [polypeptide binding]; other site
378806007682	Pectinacetylesterase; Region: PAE; pfam03283
378806007683	outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049
378806007684	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
378806007685	Carbohydrate binding domain (family 25); Region: CBM_25; cl04060
378806007686	Carbohydrate binding domain; Region: CBM_25; smart01066
378806007687	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806007688	Interdomain contacts; other site
378806007689	Cytokine receptor motif; other site
378806007690	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
378806007691	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
378806007692	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
378806007693	active site
378806007694	catalytic site [active]
378806007695	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806007696	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806007697	active site
378806007698	ATP binding site [chemical binding]; other site
378806007699	substrate binding site [chemical binding]; other site
378806007700	activation loop (A-loop); other site
378806007701	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
378806007702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806007703	S-adenosylmethionine binding site [chemical binding]; other site
378806007704	classical (c) SDRs; Region: SDR_c; cd05233
378806007705	NAD(P) binding site [chemical binding]; other site
378806007706	active site
378806007707	Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897
378806007708	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806007709	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806007710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806007711	binding surface
378806007712	TPR motif; other site
378806007713	Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056
378806007714	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
378806007715	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
378806007716	hypothetical protein; Provisional; Region: PRK07907
378806007717	metal binding site [ion binding]; metal-binding site
378806007718	putative dimer interface [polypeptide binding]; other site
378806007719	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
378806007720	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
378806007721	dimer interface [polypeptide binding]; other site
378806007722	acyl-activating enzyme (AAE) consensus motif; other site
378806007723	putative active site [active]
378806007724	AMP binding site [chemical binding]; other site
378806007725	putative CoA binding site [chemical binding]; other site
378806007726	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
378806007727	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
378806007728	metal binding site [ion binding]; metal-binding site
378806007729	putative dimer interface [polypeptide binding]; other site
378806007730	phosphoglucomutase; Validated; Region: PRK07564
378806007731	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
378806007732	active site
378806007733	substrate binding site [chemical binding]; other site
378806007734	metal binding site [ion binding]; metal-binding site
378806007735	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806007736	Coenzyme A binding pocket [chemical binding]; other site
378806007737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806007738	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
378806007739	putative substrate translocation pore; other site
378806007740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
378806007741	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
378806007742	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
378806007743	Walker A/P-loop; other site
378806007744	ATP binding site [chemical binding]; other site
378806007745	Q-loop/lid; other site
378806007746	ABC transporter signature motif; other site
378806007747	Walker B; other site
378806007748	D-loop; other site
378806007749	H-loop/switch region; other site
378806007750	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
378806007751	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806007752	dimer interface [polypeptide binding]; other site
378806007753	conserved gate region; other site
378806007754	putative PBP binding loops; other site
378806007755	ABC-ATPase subunit interface; other site
378806007756	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
378806007757	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806007758	dimer interface [polypeptide binding]; other site
378806007759	conserved gate region; other site
378806007760	putative PBP binding loops; other site
378806007761	ABC-ATPase subunit interface; other site
378806007762	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
378806007763	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
378806007764	sulfite reductase subunit beta; Provisional; Region: PRK13504
378806007765	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
378806007766	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
378806007767	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
378806007768	Flavodoxin; Region: Flavodoxin_1; pfam00258
378806007769	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
378806007770	FAD binding pocket [chemical binding]; other site
378806007771	FAD binding motif [chemical binding]; other site
378806007772	catalytic residues [active]
378806007773	NAD binding pocket [chemical binding]; other site
378806007774	phosphate binding motif [ion binding]; other site
378806007775	beta-alpha-beta structure motif; other site
378806007776	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
378806007777	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
378806007778	CysD dimerization site [polypeptide binding]; other site
378806007779	G1 box; other site
378806007780	putative GEF interaction site [polypeptide binding]; other site
378806007781	GTP/Mg2+ binding site [chemical binding]; other site
378806007782	Switch I region; other site
378806007783	G2 box; other site
378806007784	G3 box; other site
378806007785	Switch II region; other site
378806007786	G4 box; other site
378806007787	G5 box; other site
378806007788	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
378806007789	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
378806007790	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
378806007791	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
378806007792	Active Sites [active]
378806007793	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
378806007794	active site
378806007795	SAM binding site [chemical binding]; other site
378806007796	homodimer interface [polypeptide binding]; other site
378806007797	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
378806007798	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
378806007799	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
378806007800	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
378806007801	Active Sites [active]
378806007802	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806007803	dimerization interface [polypeptide binding]; other site
378806007804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806007805	dimer interface [polypeptide binding]; other site
378806007806	phosphorylation site [posttranslational modification]
378806007807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806007808	ATP binding site [chemical binding]; other site
378806007809	Mg2+ binding site [ion binding]; other site
378806007810	G-X-G motif; other site
378806007811	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
378806007812	GSH binding site [chemical binding]; other site
378806007813	catalytic residues [active]
378806007814	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
378806007815	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
378806007816	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
378806007817	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
378806007818	catalytic site [active]
378806007819	active site
378806007820	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
378806007821	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
378806007822	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806007823	putative active site [active]
378806007824	heme pocket [chemical binding]; other site
378806007825	PAS domain; Region: PAS_8; pfam13188
378806007826	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806007827	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806007828	putative active site [active]
378806007829	heme pocket [chemical binding]; other site
378806007830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806007831	ATP binding site [chemical binding]; other site
378806007832	Mg2+ binding site [ion binding]; other site
378806007833	G-X-G motif; other site
378806007834	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806007835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806007836	active site
378806007837	phosphorylation site [posttranslational modification]
378806007838	intermolecular recognition site; other site
378806007839	dimerization interface [polypeptide binding]; other site
378806007840	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
378806007841	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
378806007842	Protein of unknown function (DUF423); Region: DUF423; pfam04241
378806007843	Proteins containing SET domain [General function prediction only]; Region: COG2940
378806007844	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
378806007845	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806007846	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
378806007847	FtsX-like permease family; Region: FtsX; pfam02687
378806007848	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806007849	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806007850	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
378806007851	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
378806007852	Walker A/P-loop; other site
378806007853	ATP binding site [chemical binding]; other site
378806007854	Q-loop/lid; other site
378806007855	ABC transporter signature motif; other site
378806007856	Walker B; other site
378806007857	D-loop; other site
378806007858	H-loop/switch region; other site
378806007859	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
378806007860	Acyl-CoA dehydrogenase, middle domain; Region: Acyl-CoA_dh_M; pfam02770
378806007861	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
378806007862	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
378806007863	active site
378806007864	metal binding site [ion binding]; metal-binding site
378806007865	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
378806007866	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806007867	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806007868	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
378806007869	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806007870	Walker A/P-loop; other site
378806007871	ATP binding site [chemical binding]; other site
378806007872	Q-loop/lid; other site
378806007873	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806007874	ABC transporter signature motif; other site
378806007875	Walker B; other site
378806007876	D-loop; other site
378806007877	H-loop/switch region; other site
378806007878	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806007879	Walker A/P-loop; other site
378806007880	ATP binding site [chemical binding]; other site
378806007881	Q-loop/lid; other site
378806007882	ABC transporter signature motif; other site
378806007883	Walker B; other site
378806007884	D-loop; other site
378806007885	H-loop/switch region; other site
378806007886	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806007887	Walker A/P-loop; other site
378806007888	ATP binding site [chemical binding]; other site
378806007889	Q-loop/lid; other site
378806007890	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
378806007891	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
378806007892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806007893	Walker A/P-loop; other site
378806007894	ATP binding site [chemical binding]; other site
378806007895	Q-loop/lid; other site
378806007896	ABC transporter signature motif; other site
378806007897	Walker B; other site
378806007898	D-loop; other site
378806007899	H-loop/switch region; other site
378806007900	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
378806007901	Amidase; Region: Amidase; cl11426
378806007902	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
378806007903	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806007904	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
378806007905	Protein of unknown function (DUF2378); Region: DUF2378; cl15288
378806007906	putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266
378806007907	YcaO-like family; Region: YcaO; pfam02624
378806007908	TfuA-like protein; Region: TfuA; pfam07812
378806007909	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
378806007910	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
378806007911	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
378806007912	minor groove reading motif; other site
378806007913	helix-hairpin-helix signature motif; other site
378806007914	substrate binding pocket [chemical binding]; other site
378806007915	active site
378806007916	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
378806007917	DNA methylase; Region: N6_N4_Mtase; pfam01555
378806007918	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
378806007919	substrate binding site [chemical binding]; other site
378806007920	multimerization interface [polypeptide binding]; other site
378806007921	ATP binding site [chemical binding]; other site
378806007922	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
378806007923	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
378806007924	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
378806007925	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
378806007926	oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728
378806007927	OPT oligopeptide transporter protein; Region: OPT; pfam03169
378806007928	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806007929	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806007930	active site
378806007931	ATP binding site [chemical binding]; other site
378806007932	substrate binding site [chemical binding]; other site
378806007933	activation loop (A-loop); other site
378806007934	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
378806007935	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806007936	Coenzyme A binding pocket [chemical binding]; other site
378806007937	Protein of unknown function (DUF2379); Region: DUF2379; cl15283
378806007938	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806007939	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
378806007940	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
378806007941	dimer interface [polypeptide binding]; other site
378806007942	N-terminal domain interface [polypeptide binding]; other site
378806007943	substrate binding pocket (H-site) [chemical binding]; other site
378806007944	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
378806007945	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
378806007946	active site
378806007947	catalytic triad [active]
378806007948	dimer interface [polypeptide binding]; other site
378806007949	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806007950	putative catalytic site [active]
378806007951	putative metal binding site [ion binding]; other site
378806007952	putative phosphate binding site [ion binding]; other site
378806007953	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806007954	putative catalytic site [active]
378806007955	putative phosphate binding site [ion binding]; other site
378806007956	putative metal binding site [ion binding]; other site
378806007957	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
378806007958	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
378806007959	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
378806007960	putative dimer interface [polypeptide binding]; other site
378806007961	N-terminal domain interface [polypeptide binding]; other site
378806007962	putative substrate binding pocket (H-site) [chemical binding]; other site
378806007963	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806007964	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
378806007965	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806007966	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806007967	active site
378806007968	ATP binding site [chemical binding]; other site
378806007969	substrate binding site [chemical binding]; other site
378806007970	activation loop (A-loop); other site
378806007971	PilZ domain; Region: PilZ; pfam07238
378806007972	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
378806007973	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806007974	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806007975	Walker A/P-loop; other site
378806007976	ATP binding site [chemical binding]; other site
378806007977	Q-loop/lid; other site
378806007978	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806007979	ABC transporter signature motif; other site
378806007980	Walker B; other site
378806007981	D-loop; other site
378806007982	ABC transporter; Region: ABC_tran_2; pfam12848
378806007983	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806007984	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
378806007985	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
378806007986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806007987	Walker A/P-loop; other site
378806007988	ATP binding site [chemical binding]; other site
378806007989	Q-loop/lid; other site
378806007990	ABC transporter signature motif; other site
378806007991	Walker B; other site
378806007992	D-loop; other site
378806007993	H-loop/switch region; other site
378806007994	ABC transporter; Region: ABC_tran_2; pfam12848
378806007995	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806007996	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
378806007997	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
378806007998	ATP binding site [chemical binding]; other site
378806007999	Mg++ binding site [ion binding]; other site
378806008000	motif III; other site
378806008001	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806008002	nucleotide binding region [chemical binding]; other site
378806008003	ATP-binding site [chemical binding]; other site
378806008004	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
378806008005	elongation factor G; Reviewed; Region: PRK12740
378806008006	G1 box; other site
378806008007	putative GEF interaction site [polypeptide binding]; other site
378806008008	GTP/Mg2+ binding site [chemical binding]; other site
378806008009	Switch I region; other site
378806008010	G2 box; other site
378806008011	G3 box; other site
378806008012	Switch II region; other site
378806008013	G4 box; other site
378806008014	G5 box; other site
378806008015	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
378806008016	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
378806008017	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097
378806008018	SnoaL-like domain; Region: SnoaL_2; pfam12680
378806008019	Bacterial SH3 domain; Region: SH3_4; pfam06347
378806008020	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806008021	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806008022	active site
378806008023	ATP binding site [chemical binding]; other site
378806008024	substrate binding site [chemical binding]; other site
378806008025	activation loop (A-loop); other site
378806008026	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806008027	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806008028	DNA binding residues [nucleotide binding]
378806008029	dimerization interface [polypeptide binding]; other site
378806008030	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
378806008031	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
378806008032	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806008033	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
378806008034	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
378806008035	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
378806008036	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806008037	RNA binding surface [nucleotide binding]; other site
378806008038	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
378806008039	active site
378806008040	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
378806008041	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
378806008042	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806008043	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
378806008044	MG2 domain; Region: A2M_N; pfam01835
378806008045	Alpha-2-macroglobulin family; Region: A2M; pfam00207
378806008046	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
378806008047	surface patch; other site
378806008048	thioester region; other site
378806008049	specificity defining residues; other site
378806008050	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
378806008051	Transglycosylase; Region: Transgly; pfam00912
378806008052	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
378806008053	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
378806008054	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806008055	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806008056	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806008057	DNA binding residues [nucleotide binding]
378806008058	TPR repeat; Region: TPR_11; pfam13414
378806008059	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008060	binding surface
378806008061	TPR motif; other site
378806008062	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
378806008063	CotH protein; Region: CotH; pfam08757
378806008064	CHASE3 domain; Region: CHASE3; pfam05227
378806008065	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806008066	GAF domain; Region: GAF_2; pfam13185
378806008067	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806008068	dimer interface [polypeptide binding]; other site
378806008069	phosphorylation site [posttranslational modification]
378806008070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806008071	ATP binding site [chemical binding]; other site
378806008072	Mg2+ binding site [ion binding]; other site
378806008073	G-X-G motif; other site
378806008074	Response regulator receiver domain; Region: Response_reg; pfam00072
378806008075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806008076	active site
378806008077	phosphorylation site [posttranslational modification]
378806008078	intermolecular recognition site; other site
378806008079	dimerization interface [polypeptide binding]; other site
378806008080	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806008081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806008082	active site
378806008083	phosphorylation site [posttranslational modification]
378806008084	intermolecular recognition site; other site
378806008085	dimerization interface [polypeptide binding]; other site
378806008086	Response regulator receiver domain; Region: Response_reg; pfam00072
378806008087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806008088	active site
378806008089	phosphorylation site [posttranslational modification]
378806008090	intermolecular recognition site; other site
378806008091	dimerization interface [polypeptide binding]; other site
378806008092	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
378806008093	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
378806008094	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
378806008095	CheB methylesterase; Region: CheB_methylest; pfam01339
378806008096	Response regulator receiver domain; Region: Response_reg; pfam00072
378806008097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806008098	active site
378806008099	phosphorylation site [posttranslational modification]
378806008100	intermolecular recognition site; other site
378806008101	dimerization interface [polypeptide binding]; other site
378806008102	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806008103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806008104	dimer interface [polypeptide binding]; other site
378806008105	phosphorylation site [posttranslational modification]
378806008106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806008107	ATP binding site [chemical binding]; other site
378806008108	Mg2+ binding site [ion binding]; other site
378806008109	G-X-G motif; other site
378806008110	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806008111	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806008112	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806008113	calcium binding site 2 [ion binding]; other site
378806008114	active site
378806008115	catalytic triad [active]
378806008116	calcium binding site 1 [ion binding]; other site
378806008117	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
378806008118	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
378806008119	dimerization interface [polypeptide binding]; other site
378806008120	mannose binding site [chemical binding]; other site
378806008121	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
378806008122	Surface antigen; Region: Bac_surface_Ag; pfam01103
378806008123	LVIVD repeat; Region: LVIVD; pfam08309
378806008124	Uncharacterized conserved protein [Function unknown]; Region: COG5276
378806008125	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
378806008126	Predicted transcriptional regulators [Transcription]; Region: COG1695
378806008127	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
378806008128	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806008129	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
378806008130	active site
378806008131	metal binding site [ion binding]; metal-binding site
378806008132	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008133	binding surface
378806008134	TPR motif; other site
378806008135	D-allose transporter ATP-binding protein; Provisional; Region: PRK09700
378806008136	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806008137	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
378806008138	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806008139	DNA binding residues [nucleotide binding]
378806008140	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
378806008141	type III secretion system protein; Reviewed; Region: PRK06937
378806008142	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
378806008143	Flagellar assembly protein FliH; Region: FliH; pfam02108
378806008144	type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546
378806008145	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
378806008146	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
378806008147	Walker A motif/ATP binding site; other site
378806008148	Walker B motif; other site
378806008149	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
378806008150	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
378806008151	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
378806008152	FliP family; Region: FliP; cl00593
378806008153	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
378806008154	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
378806008155	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
378806008156	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
378806008157	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
378806008158	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
378806008159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008160	TPR motif; other site
378806008161	binding surface
378806008162	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
378806008163	Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481
378806008164	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
378806008165	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008166	TPR motif; other site
378806008167	binding surface
378806008168	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008169	TPR motif; other site
378806008170	binding surface
378806008171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008172	TPR repeat; Region: TPR_11; pfam13414
378806008173	binding surface
378806008174	TPR motif; other site
378806008175	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
378806008176	active site
378806008177	substrate binding site [chemical binding]; other site
378806008178	cosubstrate binding site; other site
378806008179	catalytic site [active]
378806008180	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
378806008181	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
378806008182	FHIPEP family; Region: FHIPEP; pfam00771
378806008183	Methyltransferase domain; Region: Methyltransf_31; pfam13847
378806008184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806008185	S-adenosylmethionine binding site [chemical binding]; other site
378806008186	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806008187	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806008188	phosphopeptide binding site; other site
378806008189	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806008190	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806008191	phosphopeptide binding site; other site
378806008192	TPR repeat; Region: TPR_11; pfam13414
378806008193	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008194	TPR motif; other site
378806008195	TPR repeat; Region: TPR_11; pfam13414
378806008196	binding surface
378806008197	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008198	binding surface
378806008199	TPR motif; other site
378806008200	TPR repeat; Region: TPR_11; pfam13414
378806008201	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008202	binding surface
378806008203	TPR motif; other site
378806008204	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806008205	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806008206	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806008207	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806008208	RDD family; Region: RDD; pfam06271
378806008209	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
378806008210	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
378806008211	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806008212	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806008213	ligand binding site [chemical binding]; other site
378806008214	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
378806008215	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806008216	active site
378806008217	metal binding site [ion binding]; metal-binding site
378806008218	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
378806008219	Integral membrane protein DUF95; Region: DUF95; pfam01944
378806008220	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
378806008221	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
378806008222	N- and C-terminal domain interface [polypeptide binding]; other site
378806008223	active site
378806008224	MgATP binding site [chemical binding]; other site
378806008225	catalytic site [active]
378806008226	metal binding site [ion binding]; metal-binding site
378806008227	xylulose binding site [chemical binding]; other site
378806008228	putative homodimer interface [polypeptide binding]; other site
378806008229	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806008230	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806008231	catalytic residue [active]
378806008232	Predicted membrane protein [Function unknown]; Region: COG2259
378806008233	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
378806008234	active site
378806008235	catalytic triad [active]
378806008236	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
378806008237	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806008238	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
378806008239	Protein of unknown function (DUF1637); Region: DUF1637; pfam07847
378806008240	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
378806008241	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806008242	Methyltransferase domain; Region: Methyltransf_31; pfam13847
378806008243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806008244	S-adenosylmethionine binding site [chemical binding]; other site
378806008245	MarR family; Region: MarR_2; cl17246
378806008246	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
378806008247	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806008248	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806008249	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
378806008250	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
378806008251	NADP binding site [chemical binding]; other site
378806008252	dimer interface [polypeptide binding]; other site
378806008253	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
378806008254	dimer interface [polypeptide binding]; other site
378806008255	phosphorylation site [posttranslational modification]
378806008256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806008257	ATP binding site [chemical binding]; other site
378806008258	Mg2+ binding site [ion binding]; other site
378806008259	G-X-G motif; other site
378806008260	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806008261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806008262	active site
378806008263	phosphorylation site [posttranslational modification]
378806008264	intermolecular recognition site; other site
378806008265	dimerization interface [polypeptide binding]; other site
378806008266	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806008267	DNA binding site [nucleotide binding]
378806008268	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
378806008269	Amidase; Region: Amidase; cl11426
378806008270	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806008271	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806008272	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806008273	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
378806008274	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
378806008275	putative active site [active]
378806008276	putative NTP binding site [chemical binding]; other site
378806008277	putative nucleic acid binding site [nucleotide binding]; other site
378806008278	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806008279	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
378806008280	Cupin domain; Region: Cupin_2; pfam07883
378806008281	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
378806008282	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
378806008283	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806008284	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806008285	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
378806008286	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
378806008287	dimer interface [polypeptide binding]; other site
378806008288	catalytic residue [active]
378806008289	potential frameshift: common BLAST hit: gi|108759366|ref|YP_629996.1| GntR family transcriptional regulator
378806008290	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806008291	DNA-binding site [nucleotide binding]; DNA binding site
378806008292	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
378806008293	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806008294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806008295	homodimer interface [polypeptide binding]; other site
378806008296	catalytic residue [active]
378806008297	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
378806008298	Protein of unknown function DUF58; Region: DUF58; pfam01882
378806008299	MoxR-like ATPases [General function prediction only]; Region: COG0714
378806008300	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806008301	Walker A motif; other site
378806008302	ATP binding site [chemical binding]; other site
378806008303	Walker B motif; other site
378806008304	arginine finger; other site
378806008305	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
378806008306	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
378806008307	dimerization interface [polypeptide binding]; other site
378806008308	active site
378806008309	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
378806008310	Creatinine amidohydrolase; Region: Creatininase; pfam02633
378806008311	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
378806008312	Helix-turn-helix domain; Region: HTH_18; pfam12833
378806008313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806008314	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806008315	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
378806008316	NlpC/P60 family; Region: NLPC_P60; cl17555
378806008317	aminotransferase; Validated; Region: PRK07777
378806008318	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806008319	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806008320	homodimer interface [polypeptide binding]; other site
378806008321	catalytic residue [active]
378806008322	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
378806008323	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806008324	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806008325	MerC mercury resistance protein; Region: MerC; pfam03203
378806008326	Protein of unknown function (DUF418); Region: DUF418; pfam04235
378806008327	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
378806008328	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
378806008329	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
378806008330	NAD(P) binding site [chemical binding]; other site
378806008331	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806008332	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
378806008333	inhibitor-cofactor binding pocket; inhibition site
378806008334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806008335	catalytic residue [active]
378806008336	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
378806008337	Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982
378806008338	active site
378806008339	homotetramer interface [polypeptide binding]; other site
378806008340	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
378806008341	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806008342	NAD(P) binding site [chemical binding]; other site
378806008343	active site
378806008344	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
378806008345	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
378806008346	Metal-binding active site; metal-binding site
378806008347	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
378806008348	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
378806008349	active site
378806008350	dimer interface [polypeptide binding]; other site
378806008351	metal binding site [ion binding]; metal-binding site
378806008352	glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
378806008353	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
378806008354	active site
378806008355	Substrate binding site; other site
378806008356	Mg++ binding site; other site
378806008357	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
378806008358	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
378806008359	transcription termination factor Rho; Provisional; Region: PRK12608
378806008360	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806008361	Walker A motif; other site
378806008362	ATP binding site [chemical binding]; other site
378806008363	Walker B motif; other site
378806008364	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
378806008365	tandem repeat interface [polypeptide binding]; other site
378806008366	oligomer interface [polypeptide binding]; other site
378806008367	active site residues [active]
378806008368	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
378806008369	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
378806008370	tandem repeat interface [polypeptide binding]; other site
378806008371	oligomer interface [polypeptide binding]; other site
378806008372	active site residues [active]
378806008373	PEGA domain; Region: PEGA; pfam08308
378806008374	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008375	binding surface
378806008376	TPR motif; other site
378806008377	PEGA domain; Region: PEGA; pfam08308
378806008378	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
378806008379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806008380	Mg2+ binding site [ion binding]; other site
378806008381	G-X-G motif; other site
378806008382	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
378806008383	anchoring element; other site
378806008384	dimer interface [polypeptide binding]; other site
378806008385	ATP binding site [chemical binding]; other site
378806008386	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
378806008387	active site
378806008388	putative metal-binding site [ion binding]; other site
378806008389	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
378806008390	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
378806008391	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
378806008392	CAP-like domain; other site
378806008393	active site
378806008394	primary dimer interface [polypeptide binding]; other site
378806008395	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
378806008396	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806008397	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806008398	active site
378806008399	ATP binding site [chemical binding]; other site
378806008400	substrate binding site [chemical binding]; other site
378806008401	activation loop (A-loop); other site
378806008402	MG2 domain; Region: A2M_N; pfam01835
378806008403	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
378806008404	MG2 domain; Region: A2M_N; pfam01835
378806008405	Alpha-2-macroglobulin family; Region: A2M; pfam00207
378806008406	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
378806008407	surface patch; other site
378806008408	thioester region; other site
378806008409	A-macroglobulin complement component; Region: A2M_comp; pfam07678
378806008410	specificity defining residues; other site
378806008411	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
378806008412	Protein export membrane protein; Region: SecD_SecF; cl14618
378806008413	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
378806008414	Protein export membrane protein; Region: SecD_SecF; cl14618
378806008415	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806008416	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806008417	Tho complex subunit 7; Region: THOC7; pfam05615
378806008418	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806008419	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
378806008420	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806008421	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806008422	active site
378806008423	metal binding site [ion binding]; metal-binding site
378806008424	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806008425	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806008426	active site
378806008427	catalytic tetrad [active]
378806008428	GAF domain; Region: GAF_3; pfam13492
378806008429	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806008430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806008431	dimer interface [polypeptide binding]; other site
378806008432	phosphorylation site [posttranslational modification]
378806008433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806008434	ATP binding site [chemical binding]; other site
378806008435	Mg2+ binding site [ion binding]; other site
378806008436	G-X-G motif; other site
378806008437	Response regulator receiver domain; Region: Response_reg; pfam00072
378806008438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806008439	active site
378806008440	phosphorylation site [posttranslational modification]
378806008441	intermolecular recognition site; other site
378806008442	dimerization interface [polypeptide binding]; other site
378806008443	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806008444	dimer interface [polypeptide binding]; other site
378806008445	phosphorylation site [posttranslational modification]
378806008446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806008447	ATP binding site [chemical binding]; other site
378806008448	G-X-G motif; other site
378806008449	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
378806008450	Peptidase S46; Region: Peptidase_S46; pfam10459
378806008451	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806008452	High potential iron-sulfur protein; Region: HIPIP; pfam01355
378806008453	Ycf46; Provisional; Region: ycf46; CHL00195
378806008454	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806008455	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806008456	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
378806008457	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
378806008458	active site
378806008459	oxyanion hole [active]
378806008460	catalytic triad [active]
378806008461	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
378806008462	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
378806008463	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
378806008464	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
378806008465	POT family; Region: PTR2; cl17359
378806008466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806008467	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806008468	putative substrate translocation pore; other site
378806008469	glutathionine S-transferase; Provisional; Region: PRK10542
378806008470	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
378806008471	C-terminal domain interface [polypeptide binding]; other site
378806008472	GSH binding site (G-site) [chemical binding]; other site
378806008473	dimer interface [polypeptide binding]; other site
378806008474	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
378806008475	dimer interface [polypeptide binding]; other site
378806008476	N-terminal domain interface [polypeptide binding]; other site
378806008477	substrate binding pocket (H-site) [chemical binding]; other site
378806008478	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
378806008479	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806008480	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806008481	DNA binding residues [nucleotide binding]
378806008482	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806008483	phosphopeptide binding site; other site
378806008484	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806008485	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806008486	phosphopeptide binding site; other site
378806008487	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806008488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806008489	Walker A motif; other site
378806008490	ATP binding site [chemical binding]; other site
378806008491	Walker B motif; other site
378806008492	arginine finger; other site
378806008493	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806008494	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
378806008495	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
378806008496	Competence protein A; Region: Competence_A; pfam11104
378806008497	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
378806008498	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806008499	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
378806008500	PilX N-terminal; Region: PilX_N; pfam14341
378806008501	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
378806008502	type II secretion system protein J; Region: gspJ; TIGR01711
378806008503	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
378806008504	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
378806008505	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
378806008506	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
378806008507	type II secretion system protein F; Region: GspF; TIGR02120
378806008508	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
378806008509	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
378806008510	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806008511	type II secretion system protein E; Region: type_II_gspE; TIGR02533
378806008512	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
378806008513	Walker A motif; other site
378806008514	ATP binding site [chemical binding]; other site
378806008515	Walker B motif; other site
378806008516	type II secretion system protein D; Region: type_II_gspD; TIGR02517
378806008517	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
378806008518	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
378806008519	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
378806008520	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
378806008521	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
378806008522	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
378806008523	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
378806008524	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806008525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806008526	active site
378806008527	phosphorylation site [posttranslational modification]
378806008528	intermolecular recognition site; other site
378806008529	dimerization interface [polypeptide binding]; other site
378806008530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806008531	Walker A motif; other site
378806008532	ATP binding site [chemical binding]; other site
378806008533	Walker B motif; other site
378806008534	arginine finger; other site
378806008535	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806008536	Erythromycin esterase; Region: Erythro_esteras; pfam05139
378806008537	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
378806008538	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
378806008539	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806008540	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806008541	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
378806008542	substrate binding pocket [chemical binding]; other site
378806008543	dimerization interface [polypeptide binding]; other site
378806008544	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
378806008545	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
378806008546	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806008547	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
378806008548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806008549	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806008550	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
378806008551	putative active site [active]
378806008552	heme pocket [chemical binding]; other site
378806008553	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806008554	putative active site [active]
378806008555	heme pocket [chemical binding]; other site
378806008556	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806008557	GAF domain; Region: GAF; pfam01590
378806008558	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806008559	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806008560	dimer interface [polypeptide binding]; other site
378806008561	phosphorylation site [posttranslational modification]
378806008562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806008563	ATP binding site [chemical binding]; other site
378806008564	Mg2+ binding site [ion binding]; other site
378806008565	G-X-G motif; other site
378806008566	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
378806008567	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
378806008568	metal ion-dependent adhesion site (MIDAS); other site
378806008569	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
378806008570	MoxR-like ATPases [General function prediction only]; Region: COG0714
378806008571	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806008572	Walker A motif; other site
378806008573	ATP binding site [chemical binding]; other site
378806008574	Walker B motif; other site
378806008575	arginine finger; other site
378806008576	SWIM zinc finger; Region: SWIM; pfam04434
378806008577	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
378806008578	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
378806008579	Ligand Binding Site [chemical binding]; other site
378806008580	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
378806008581	Ligand Binding Site [chemical binding]; other site
378806008582	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
378806008583	Ligand Binding Site [chemical binding]; other site
378806008584	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806008585	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806008586	active site
378806008587	ATP binding site [chemical binding]; other site
378806008588	substrate binding site [chemical binding]; other site
378806008589	activation loop (A-loop); other site
378806008590	PEGA domain; Region: PEGA; pfam08308
378806008591	Transcriptional regulators [Transcription]; Region: MarR; COG1846
378806008592	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806008593	putative DNA binding site [nucleotide binding]; other site
378806008594	putative Zn2+ binding site [ion binding]; other site
378806008595	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806008596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806008597	putative substrate translocation pore; other site
378806008598	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
378806008599	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
378806008600	tetrameric interface [polypeptide binding]; other site
378806008601	activator binding site; other site
378806008602	NADP binding site [chemical binding]; other site
378806008603	substrate binding site [chemical binding]; other site
378806008604	catalytic residues [active]
378806008605	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
378806008606	Sulfatase; Region: Sulfatase; pfam00884
378806008607	Cupin domain; Region: Cupin_2; pfam07883
378806008608	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
378806008609	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806008610	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
378806008611	catalytic site [active]
378806008612	aspartate kinase; Reviewed; Region: PRK06635
378806008613	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
378806008614	putative nucleotide binding site [chemical binding]; other site
378806008615	putative catalytic residues [active]
378806008616	putative Mg ion binding site [ion binding]; other site
378806008617	putative aspartate binding site [chemical binding]; other site
378806008618	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
378806008619	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
378806008620	putative allosteric regulatory residue; other site
378806008621	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806008622	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
378806008623	acyl-activating enzyme (AAE) consensus motif; other site
378806008624	AMP binding site [chemical binding]; other site
378806008625	active site
378806008626	CoA binding site [chemical binding]; other site
378806008627	Class I aldolases; Region: Aldolase_Class_I; cl17187
378806008628	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
378806008629	catalytic residue [active]
378806008630	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806008631	FtsX-like permease family; Region: FtsX; pfam02687
378806008632	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806008633	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
378806008634	FtsX-like permease family; Region: FtsX; pfam02687
378806008635	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
378806008636	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
378806008637	Walker A/P-loop; other site
378806008638	ATP binding site [chemical binding]; other site
378806008639	Q-loop/lid; other site
378806008640	ABC transporter signature motif; other site
378806008641	Walker B; other site
378806008642	D-loop; other site
378806008643	H-loop/switch region; other site
378806008644	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806008645	AMP-binding enzyme; Region: AMP-binding; pfam00501
378806008646	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806008647	acyl-activating enzyme (AAE) consensus motif; other site
378806008648	acyl-activating enzyme (AAE) consensus motif; other site
378806008649	AMP binding site [chemical binding]; other site
378806008650	active site
378806008651	CoA binding site [chemical binding]; other site
378806008652	peptide synthase; Provisional; Region: PRK12316
378806008653	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806008654	Male sterility protein; Region: NAD_binding_4; pfam07993
378806008655	NAD(P) binding site [chemical binding]; other site
378806008656	active site
378806008657	3-dehydroquinate synthase; Provisional; Region: PRK02290
378806008658	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
378806008659	OPT oligopeptide transporter protein; Region: OPT; cl14607
378806008660	OPT oligopeptide transporter protein; Region: OPT; cl14607
378806008661	ParB-like nuclease domain; Region: ParB; smart00470
378806008662	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
378806008663	Tocopherol cyclase; Region: Tocopherol_cycl; cl14571
378806008664	protease TldD; Provisional; Region: tldD; PRK10735
378806008665	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806008666	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806008667	phosphopeptide binding site; other site
378806008668	TPR repeat; Region: TPR_11; pfam13414
378806008669	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008670	binding surface
378806008671	TPR motif; other site
378806008672	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806008673	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806008674	ligand binding site [chemical binding]; other site
378806008675	flexible hinge region; other site
378806008676	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806008677	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806008678	ligand binding site [chemical binding]; other site
378806008679	flexible hinge region; other site
378806008680	SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833
378806008681	active site
378806008682	catalytic triad [active]
378806008683	oxyanion hole [active]
378806008684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806008685	binding surface
378806008686	TPR motif; other site
378806008687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008688	binding surface
378806008689	TPR motif; other site
378806008690	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
378806008691	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
378806008692	putative active site [active]
378806008693	putative substrate binding site [chemical binding]; other site
378806008694	ATP binding site [chemical binding]; other site
378806008695	SnoaL-like domain; Region: SnoaL_3; pfam13474
378806008696	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
378806008697	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
378806008698	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008699	TPR motif; other site
378806008700	binding surface
378806008701	Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266
378806008702	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
378806008703	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
378806008704	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
378806008705	NADP binding site [chemical binding]; other site
378806008706	dimer interface [polypeptide binding]; other site
378806008707	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
378806008708	putative deacylase active site [active]
378806008709	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
378806008710	ATP-grasp domain; Region: ATP-grasp; pfam02222
378806008711	AIR carboxylase; Region: AIRC; pfam00731
378806008712	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
378806008713	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
378806008714	metal ion-dependent adhesion site (MIDAS); other site
378806008715	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806008716	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806008717	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806008718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806008719	putative phosphate acyltransferase; Provisional; Region: PRK05331
378806008720	Uncharacterized conserved protein [Function unknown]; Region: COG4850
378806008721	Predicted periplasmic protein [Function unknown]; Region: COG3698
378806008722	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
378806008723	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
378806008724	catalytic triad [active]
378806008725	putative active site [active]
378806008726	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
378806008727	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
378806008728	poly(A) polymerase; Region: pcnB; TIGR01942
378806008729	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
378806008730	active site
378806008731	NTP binding site [chemical binding]; other site
378806008732	metal binding triad [ion binding]; metal-binding site
378806008733	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
378806008734	type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898
378806008735	Peptidase C39 family; Region: Peptidase_C39; pfam03412
378806008736	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
378806008737	putative active site [active]
378806008738	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
378806008739	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806008740	Walker A/P-loop; other site
378806008741	ATP binding site [chemical binding]; other site
378806008742	Q-loop/lid; other site
378806008743	ABC transporter signature motif; other site
378806008744	Walker B; other site
378806008745	D-loop; other site
378806008746	H-loop/switch region; other site
378806008747	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806008748	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
378806008749	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806008750	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806008751	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806008752	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
378806008753	Mechanosensitive ion channel; Region: MS_channel; pfam00924
378806008754	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
378806008755	active site
378806008756	DNA polymerase IV; Validated; Region: PRK02406
378806008757	DNA binding site [nucleotide binding]
378806008758	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
378806008759	Uncharacterized conserved protein [Function unknown]; Region: COG0432
378806008760	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
378806008761	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
378806008762	acyl-activating enzyme (AAE) consensus motif; other site
378806008763	putative AMP binding site [chemical binding]; other site
378806008764	putative active site [active]
378806008765	putative CoA binding site [chemical binding]; other site
378806008766	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
378806008767	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806008768	RNA binding surface [nucleotide binding]; other site
378806008769	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806008770	active site
378806008771	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806008772	active site
378806008773	ATP binding site [chemical binding]; other site
378806008774	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806008775	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806008776	substrate binding site [chemical binding]; other site
378806008777	activation loop (A-loop); other site
378806008778	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
378806008779	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
378806008780	catalytic residue [active]
378806008781	putative FPP diphosphate  binding site; other site
378806008782	putative FPP binding hydrophobic cleft; other site
378806008783	dimer interface [polypeptide binding]; other site
378806008784	putative IPP diphosphate binding site; other site
378806008785	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
378806008786	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
378806008787	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
378806008788	active site
378806008789	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
378806008790	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806008791	protein binding site [polypeptide binding]; other site
378806008792	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
378806008793	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
378806008794	putative substrate binding region [chemical binding]; other site
378806008795	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
378806008796	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
378806008797	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
378806008798	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
378806008799	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
378806008800	PKD domain; Region: PKD; pfam00801
378806008801	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
378806008802	MoaE interaction surface [polypeptide binding]; other site
378806008803	MoeB interaction surface [polypeptide binding]; other site
378806008804	thiocarboxylated glycine; other site
378806008805	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
378806008806	MoaE homodimer interface [polypeptide binding]; other site
378806008807	MoaD interaction [polypeptide binding]; other site
378806008808	active site residues [active]
378806008809	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
378806008810	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
378806008811	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
378806008812	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
378806008813	putative substrate binding region [chemical binding]; other site
378806008814	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
378806008815	nudix motif; other site
378806008816	acetyl-CoA synthetase; Provisional; Region: PRK00174
378806008817	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
378806008818	active site
378806008819	CoA binding site [chemical binding]; other site
378806008820	acyl-activating enzyme (AAE) consensus motif; other site
378806008821	AMP binding site [chemical binding]; other site
378806008822	acetate binding site [chemical binding]; other site
378806008823	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
378806008824	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
378806008825	Probable Catalytic site; other site
378806008826	metal-binding site
378806008827	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
378806008828	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
378806008829	Probable Catalytic site; other site
378806008830	metal-binding site
378806008831	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806008832	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806008833	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
378806008834	RNA/DNA hybrid binding site [nucleotide binding]; other site
378806008835	active site
378806008836	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806008837	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
378806008838	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806008839	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806008840	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
378806008841	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
378806008842	Metal-binding active site; metal-binding site
378806008843	AP (apurinic/apyrimidinic) site pocket; other site
378806008844	YcaO-like family; Region: YcaO; pfam02624
378806008845	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
378806008846	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
378806008847	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
378806008848	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806008849	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
378806008850	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
378806008851	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139
378806008852	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
378806008853	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_3; cd11575
378806008854	putative ligand binding site [chemical binding]; other site
378806008855	putative catalytic site [active]
378806008856	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
378806008857	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
378806008858	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
378806008859	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
378806008860	protein binding site [polypeptide binding]; other site
378806008861	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
378806008862	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
378806008863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806008864	S-adenosylmethionine binding site [chemical binding]; other site
378806008865	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806008866	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806008867	active site
378806008868	metal binding site [ion binding]; metal-binding site
378806008869	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
378806008870	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
378806008871	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
378806008872	TMP-binding site; other site
378806008873	ATP-binding site [chemical binding]; other site
378806008874	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
378806008875	putative active site; other site
378806008876	putative metal binding residues [ion binding]; other site
378806008877	signature motif; other site
378806008878	putative triphosphate binding site [ion binding]; other site
378806008879	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806008880	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806008881	active site
378806008882	ATP binding site [chemical binding]; other site
378806008883	substrate binding site [chemical binding]; other site
378806008884	activation loop (A-loop); other site
378806008885	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
378806008886	active site residue [active]
378806008887	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
378806008888	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
378806008889	photoactive yellow protein; Region: photo_yellow; TIGR02373
378806008890	PAS fold; Region: PAS; pfam00989
378806008891	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
378806008892	AAA domain; Region: AAA_18; pfam13238
378806008893	Substrate-binding site [chemical binding]; other site
378806008894	Substrate specificity [chemical binding]; other site
378806008895	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
378806008896	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
378806008897	putative active site [active]
378806008898	catalytic site [active]
378806008899	putative metal binding site [ion binding]; other site
378806008900	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806008901	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806008902	active site
378806008903	ATP binding site [chemical binding]; other site
378806008904	substrate binding site [chemical binding]; other site
378806008905	activation loop (A-loop); other site
378806008906	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
378806008907	quinolinate synthetase; Provisional; Region: PRK09375
378806008908	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806008909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806008910	S-adenosylmethionine binding site [chemical binding]; other site
378806008911	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806008912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806008913	ATP binding site [chemical binding]; other site
378806008914	Mg2+ binding site [ion binding]; other site
378806008915	G-X-G motif; other site
378806008916	Response regulator receiver domain; Region: Response_reg; pfam00072
378806008917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806008918	active site
378806008919	phosphorylation site [posttranslational modification]
378806008920	intermolecular recognition site; other site
378806008921	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806008922	dimerization interface [polypeptide binding]; other site
378806008923	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806008924	dimer interface [polypeptide binding]; other site
378806008925	phosphorylation site [posttranslational modification]
378806008926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806008927	ATP binding site [chemical binding]; other site
378806008928	Mg2+ binding site [ion binding]; other site
378806008929	G-X-G motif; other site
378806008930	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
378806008931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806008932	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
378806008933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806008934	POT family; Region: PTR2; cl17359
378806008935	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
378806008936	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
378806008937	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
378806008938	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
378806008939	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
378806008940	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
378806008941	EamA-like transporter family; Region: EamA; pfam00892
378806008942	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806008943	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806008944	active site
378806008945	metal binding site [ion binding]; metal-binding site
378806008946	FOG: CBS domain [General function prediction only]; Region: COG0517
378806008947	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
378806008948	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
378806008949	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
378806008950	active site
378806008951	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
378806008952	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
378806008953	Family description; Region: UvrD_C_2; pfam13538
378806008954	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
378806008955	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
378806008956	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
378806008957	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
378806008958	TPR repeat; Region: TPR_11; pfam13414
378806008959	TPR repeat; Region: TPR_11; pfam13414
378806008960	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008961	binding surface
378806008962	TPR motif; other site
378806008963	TPR repeat; Region: TPR_11; pfam13414
378806008964	TPR repeat; Region: TPR_11; pfam13414
378806008965	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806008966	binding surface
378806008967	TPR motif; other site
378806008968	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806008969	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806008970	phosphopeptide binding site; other site
378806008971	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
378806008972	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
378806008973	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
378806008974	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
378806008975	NAD binding site [chemical binding]; other site
378806008976	ligand binding site [chemical binding]; other site
378806008977	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
378806008978	putative rRNA binding site [nucleotide binding]; other site
378806008979	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806008980	putative sugar binding sites [chemical binding]; other site
378806008981	Q-X-W motif; other site
378806008982	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
378806008983	putative ligand binding site [chemical binding]; other site
378806008984	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
378806008985	Competence protein; Region: Competence; pfam03772
378806008986	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
378806008987	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
378806008988	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806008989	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806008990	phosphopeptide binding site; other site
378806008991	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
378806008992	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806008993	active site
378806008994	HIGH motif; other site
378806008995	nucleotide binding site [chemical binding]; other site
378806008996	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
378806008997	KMSKS motif; other site
378806008998	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
378806008999	tRNA binding surface [nucleotide binding]; other site
378806009000	anticodon binding site; other site
378806009001	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806009002	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
378806009003	PA/protease or protease-like domain interface [polypeptide binding]; other site
378806009004	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
378806009005	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806009006	metal binding site [ion binding]; metal-binding site
378806009007	excinuclease ABC subunit B; Provisional; Region: PRK05298
378806009008	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806009009	ATP binding site [chemical binding]; other site
378806009010	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806009011	nucleotide binding region [chemical binding]; other site
378806009012	ATP-binding site [chemical binding]; other site
378806009013	Ultra-violet resistance protein B; Region: UvrB; pfam12344
378806009014	UvrB/uvrC motif; Region: UVR; pfam02151
378806009015	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
378806009016	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
378806009017	GIY-YIG motif/motif A; other site
378806009018	active site
378806009019	catalytic site [active]
378806009020	putative DNA binding site [nucleotide binding]; other site
378806009021	metal binding site [ion binding]; metal-binding site
378806009022	UvrB/uvrC motif; Region: UVR; pfam02151
378806009023	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
378806009024	Protein of unknown function (DUF507); Region: DUF507; pfam04368
378806009025	large tegument protein UL36; Provisional; Region: PHA03247
378806009026	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
378806009027	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
378806009028	Imelysin; Region: Peptidase_M75; pfam09375
378806009029	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
378806009030	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
378806009031	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
378806009032	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
378806009033	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
378806009034	catalytic residue [active]
378806009035	Maf-like protein; Region: Maf; pfam02545
378806009036	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
378806009037	active site
378806009038	dimer interface [polypeptide binding]; other site
378806009039	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806009040	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806009041	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806009042	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806009043	metal binding site [ion binding]; metal-binding site
378806009044	active site
378806009045	I-site; other site
378806009046	SurA N-terminal domain; Region: SurA_N_3; cl07813
378806009047	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
378806009048	rod shape-determining protein MreC; Provisional; Region: PRK13922
378806009049	Septum formation initiator; Region: DivIC; cl17659
378806009050	rod shape-determining protein MreC; Region: MreC; pfam04085
378806009051	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
378806009052	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
378806009053	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
378806009054	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
378806009055	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
378806009056	MgtE intracellular N domain; Region: MgtE_N; smart00924
378806009057	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
378806009058	Divalent cation transporter; Region: MgtE; pfam01769
378806009059	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
378806009060	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806009061	catalytic residues [active]
378806009062	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
378806009063	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
378806009064	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
378806009065	tRNA; other site
378806009066	putative tRNA binding site [nucleotide binding]; other site
378806009067	putative NADP binding site [chemical binding]; other site
378806009068	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
378806009069	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
378806009070	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
378806009071	domain interfaces; other site
378806009072	active site
378806009073	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
378806009074	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
378806009075	active site
378806009076	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
378806009077	active site
378806009078	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806009079	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
378806009080	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
378806009081	Walker A motif; other site
378806009082	ATP binding site [chemical binding]; other site
378806009083	Walker B motif; other site
378806009084	type III secretion system protein SpaO; Validated; Region: PRK08158
378806009085	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
378806009086	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
378806009087	active site
378806009088	metal binding site [ion binding]; metal-binding site
378806009089	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
378806009090	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
378806009091	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
378806009092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806009093	putative substrate translocation pore; other site
378806009094	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
378806009095	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
378806009096	tetramer interface [polypeptide binding]; other site
378806009097	TPP-binding site [chemical binding]; other site
378806009098	heterodimer interface [polypeptide binding]; other site
378806009099	phosphorylation loop region [posttranslational modification]
378806009100	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
378806009101	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
378806009102	alpha subunit interface [polypeptide binding]; other site
378806009103	TPP binding site [chemical binding]; other site
378806009104	heterodimer interface [polypeptide binding]; other site
378806009105	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
378806009106	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
378806009107	E3 interaction surface; other site
378806009108	lipoyl attachment site [posttranslational modification]; other site
378806009109	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
378806009110	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
378806009111	E3 interaction surface; other site
378806009112	lipoyl attachment site [posttranslational modification]; other site
378806009113	e3 binding domain; Region: E3_binding; pfam02817
378806009114	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
378806009115	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
378806009116	Response regulator receiver domain; Region: Response_reg; pfam00072
378806009117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806009118	active site
378806009119	phosphorylation site [posttranslational modification]
378806009120	intermolecular recognition site; other site
378806009121	dimerization interface [polypeptide binding]; other site
378806009122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806009123	ATP binding site [chemical binding]; other site
378806009124	Mg2+ binding site [ion binding]; other site
378806009125	G-X-G motif; other site
378806009126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806009127	active site
378806009128	phosphorylation site [posttranslational modification]
378806009129	intermolecular recognition site; other site
378806009130	dimerization interface [polypeptide binding]; other site
378806009131	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
378806009132	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
378806009133	HIGH motif; other site
378806009134	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
378806009135	active site
378806009136	KMSKS motif; other site
378806009137	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
378806009138	active site
378806009139	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
378806009140	active site
378806009141	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
378806009142	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
378806009143	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806009144	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806009145	active site
378806009146	ATP binding site [chemical binding]; other site
378806009147	substrate binding site [chemical binding]; other site
378806009148	activation loop (A-loop); other site
378806009149	PEGA domain; Region: PEGA; pfam08308
378806009150	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806009151	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
378806009152	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
378806009153	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
378806009154	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806009155	TPR motif; other site
378806009156	binding surface
378806009157	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806009158	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806009159	dimer interface [polypeptide binding]; other site
378806009160	putative CheW interface [polypeptide binding]; other site
378806009161	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806009162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806009163	active site
378806009164	phosphorylation site [posttranslational modification]
378806009165	intermolecular recognition site; other site
378806009166	dimerization interface [polypeptide binding]; other site
378806009167	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806009168	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
378806009169	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806009170	putative binding surface; other site
378806009171	active site
378806009172	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806009173	ATP binding site [chemical binding]; other site
378806009174	Mg2+ binding site [ion binding]; other site
378806009175	G-X-G motif; other site
378806009176	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806009177	Response regulator receiver domain; Region: Response_reg; pfam00072
378806009178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806009179	active site
378806009180	phosphorylation site [posttranslational modification]
378806009181	intermolecular recognition site; other site
378806009182	dimerization interface [polypeptide binding]; other site
378806009183	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806009184	dimer interface [polypeptide binding]; other site
378806009185	phosphorylation site [posttranslational modification]
378806009186	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
378806009187	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
378806009188	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
378806009189	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
378806009190	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
378806009191	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806009192	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806009193	putative sugar binding sites [chemical binding]; other site
378806009194	Q-X-W motif; other site
378806009195	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
378806009196	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
378806009197	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
378806009198	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806009199	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806009200	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806009201	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806009202	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806009203	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806009204	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806009205	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806009206	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806009207	Hemerythrin-like domain; Region: Hr-like; cd12108
378806009208	Fe binding site [ion binding]; other site
378806009209	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
378806009210	BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463
378806009211	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806009212	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
378806009213	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
378806009214	G1 box; other site
378806009215	GTP/Mg2+ binding site [chemical binding]; other site
378806009216	G2 box; other site
378806009217	Switch I region; other site
378806009218	G3 box; other site
378806009219	Switch II region; other site
378806009220	G4 box; other site
378806009221	G5 box; other site
378806009222	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
378806009223	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
378806009224	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
378806009225	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
378806009226	putative active site [active]
378806009227	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
378806009228	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
378806009229	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
378806009230	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
378806009231	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806009232	motif II; other site
378806009233	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
378806009234	UbiA prenyltransferase family; Region: UbiA; pfam01040
378806009235	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
378806009236	Major royal jelly protein; Region: MRJP; pfam03022
378806009237	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806009238	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806009239	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
378806009240	putative effector binding pocket; other site
378806009241	dimerization interface [polypeptide binding]; other site
378806009242	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
378806009243	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
378806009244	active site
378806009245	substrate binding site [chemical binding]; other site
378806009246	cosubstrate binding site; other site
378806009247	catalytic site [active]
378806009248	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
378806009249	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
378806009250	dimerization interface [polypeptide binding]; other site
378806009251	putative ATP binding site [chemical binding]; other site
378806009252	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806009253	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
378806009254	ligand binding site [chemical binding]; other site
378806009255	flexible hinge region; other site
378806009256	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
378806009257	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
378806009258	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
378806009259	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
378806009260	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
378806009261	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
378806009262	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
378806009263	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806009264	AMIN domain; Region: AMIN; pfam11741
378806009265	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
378806009266	Organic solvent tolerance protein; Region: OstA_C; pfam04453
378806009267	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806009268	non-specific DNA binding site [nucleotide binding]; other site
378806009269	salt bridge; other site
378806009270	sequence-specific DNA binding site [nucleotide binding]; other site
378806009271	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
378806009272	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806009273	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806009274	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
378806009275	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806009276	enoyl-CoA hydratase; Provisional; Region: PRK05995
378806009277	substrate binding site [chemical binding]; other site
378806009278	oxyanion hole (OAH) forming residues; other site
378806009279	trimer interface [polypeptide binding]; other site
378806009280	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
378806009281	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806009282	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806009283	putative catalytic site [active]
378806009284	putative metal binding site [ion binding]; other site
378806009285	putative phosphate binding site [ion binding]; other site
378806009286	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
378806009287	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
378806009288	CHASE2 domain; Region: CHASE2; cl01732
378806009289	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
378806009290	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
378806009291	cyclase homology domain; Region: CHD; cd07302
378806009292	nucleotidyl binding site; other site
378806009293	metal binding site [ion binding]; metal-binding site
378806009294	dimer interface [polypeptide binding]; other site
378806009295	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
378806009296	dimer interface [polypeptide binding]; other site
378806009297	[2Fe-2S] cluster binding site [ion binding]; other site
378806009298	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
378806009299	4Fe-4S binding domain; Region: Fer4; pfam00037
378806009300	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
378806009301	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
378806009302	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
378806009303	catalytic loop [active]
378806009304	iron binding site [ion binding]; other site
378806009305	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
378806009306	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
378806009307	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
378806009308	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
378806009309	NADH dehydrogenase subunit D; Validated; Region: PRK06075
378806009310	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
378806009311	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
378806009312	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
378806009313	cyclase homology domain; Region: CHD; cd07302
378806009314	nucleotidyl binding site; other site
378806009315	metal binding site [ion binding]; metal-binding site
378806009316	dimer interface [polypeptide binding]; other site
378806009317	Sulfatase; Region: Sulfatase; cl17466
378806009318	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
378806009319	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
378806009320	CoenzymeA binding site [chemical binding]; other site
378806009321	subunit interaction site [polypeptide binding]; other site
378806009322	PHB binding site; other site
378806009323	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
378806009324	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
378806009325	HAMP domain; Region: HAMP; pfam00672
378806009326	dimerization interface [polypeptide binding]; other site
378806009327	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806009328	dimer interface [polypeptide binding]; other site
378806009329	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
378806009330	putative CheW interface [polypeptide binding]; other site
378806009331	Response regulator receiver domain; Region: Response_reg; pfam00072
378806009332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806009333	active site
378806009334	phosphorylation site [posttranslational modification]
378806009335	intermolecular recognition site; other site
378806009336	dimerization interface [polypeptide binding]; other site
378806009337	circadian clock protein KaiC; Reviewed; Region: PRK09302
378806009338	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806009339	Walker A motif; other site
378806009340	ATP binding site [chemical binding]; other site
378806009341	Walker B motif; other site
378806009342	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806009343	ATP binding site [chemical binding]; other site
378806009344	Walker B motif; other site
378806009345	Response regulator receiver domain; Region: Response_reg; pfam00072
378806009346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806009347	active site
378806009348	phosphorylation site [posttranslational modification]
378806009349	intermolecular recognition site; other site
378806009350	dimerization interface [polypeptide binding]; other site
378806009351	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806009352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
378806009353	phosphorylation site [posttranslational modification]
378806009354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806009355	ATP binding site [chemical binding]; other site
378806009356	Mg2+ binding site [ion binding]; other site
378806009357	G-X-G motif; other site
378806009358	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
378806009359	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
378806009360	active site
378806009361	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
378806009362	Deoxyhypusine synthase; Region: DS; cl00826
378806009363	deoxyhypusine synthase; Region: dhys; TIGR00321
378806009364	OsmC-like protein; Region: OsmC; pfam02566
378806009365	Phosphoesterase family; Region: Phosphoesterase; pfam04185
378806009366	Phosphoesterase family; Region: Phosphoesterase; pfam04185
378806009367	arginine decarboxylase; Provisional; Region: PRK05354
378806009368	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
378806009369	active site
378806009370	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
378806009371	dimer interface [polypeptide binding]; other site
378806009372	catalytic residues [active]
378806009373	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
378806009374	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
378806009375	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806009376	Walker A motif; other site
378806009377	ATP binding site [chemical binding]; other site
378806009378	Walker B motif; other site
378806009379	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
378806009380	Colicin V production protein; Region: Colicin_V; pfam02674
378806009381	DnaJ domain; Region: DnaJ; pfam00226
378806009382	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806009383	MreB/Mbl protein; Region: MreB_Mbl; pfam06723
378806009384	nucleotide binding site [chemical binding]; other site
378806009385	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
378806009386	active site
378806009387	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806009388	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806009389	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806009390	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
378806009391	CAAX protease self-immunity; Region: Abi; pfam02517
378806009392	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
378806009393	Predicted flavoprotein [General function prediction only]; Region: COG0431
378806009394	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
378806009395	putative hydrophobic ligand binding site [chemical binding]; other site
378806009396	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806009397	dimerization interface [polypeptide binding]; other site
378806009398	putative DNA binding site [nucleotide binding]; other site
378806009399	putative Zn2+ binding site [ion binding]; other site
378806009400	hypothetical protein; Provisional; Region: PRK08609
378806009401	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
378806009402	active site
378806009403	primer binding site [nucleotide binding]; other site
378806009404	NTP  binding site [chemical binding]; other site
378806009405	metal binding triad [ion binding]; metal-binding site
378806009406	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
378806009407	active site
378806009408	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
378806009409	iron-sulfur cluster [ion binding]; other site
378806009410	[2Fe-2S] cluster binding site [ion binding]; other site
378806009411	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
378806009412	MPT binding site; other site
378806009413	trimer interface [polypeptide binding]; other site
378806009414	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
378806009415	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
378806009416	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
378806009417	heme-binding site [chemical binding]; other site
378806009418	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
378806009419	FAD binding pocket [chemical binding]; other site
378806009420	FAD binding motif [chemical binding]; other site
378806009421	phosphate binding motif [ion binding]; other site
378806009422	beta-alpha-beta structure motif; other site
378806009423	NAD binding pocket [chemical binding]; other site
378806009424	Heme binding  pocket [chemical binding]; other site
378806009425	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
378806009426	GAF domain; Region: GAF; pfam01590
378806009427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806009428	Walker A motif; other site
378806009429	ATP binding site [chemical binding]; other site
378806009430	Walker B motif; other site
378806009431	arginine finger; other site
378806009432	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806009433	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806009434	binding surface
378806009435	TPR motif; other site
378806009436	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806009437	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806009438	TPR motif; other site
378806009439	binding surface
378806009440	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806009441	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806009442	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806009443	binding surface
378806009444	TPR motif; other site
378806009445	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806009446	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806009447	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806009448	binding surface
378806009449	TPR motif; other site
378806009450	CHAT domain; Region: CHAT; pfam12770
378806009451	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
378806009452	dimer interface [polypeptide binding]; other site
378806009453	GSH binding site (G-site) [chemical binding]; other site
378806009454	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
378806009455	N-terminal domain interface [polypeptide binding]; other site
378806009456	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806009457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806009458	NAD(P) binding site [chemical binding]; other site
378806009459	active site
378806009460	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
378806009461	CoenzymeA binding site [chemical binding]; other site
378806009462	subunit interaction site [polypeptide binding]; other site
378806009463	PHB binding site; other site
378806009464	phosphodiesterase YaeI; Provisional; Region: PRK11340
378806009465	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
378806009466	putative active site [active]
378806009467	putative metal binding site [ion binding]; other site
378806009468	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
378806009469	catalytic site [active]
378806009470	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806009471	TPR motif; other site
378806009472	binding surface
378806009473	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
378806009474	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
378806009475	putative active site [active]
378806009476	putative catalytic site [active]
378806009477	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
378806009478	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
378806009479	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
378806009480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806009481	Walker A/P-loop; other site
378806009482	ATP binding site [chemical binding]; other site
378806009483	Q-loop/lid; other site
378806009484	ABC transporter signature motif; other site
378806009485	Walker B; other site
378806009486	D-loop; other site
378806009487	H-loop/switch region; other site
378806009488	TOBE domain; Region: TOBE_2; pfam08402
378806009489	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806009490	dimer interface [polypeptide binding]; other site
378806009491	conserved gate region; other site
378806009492	putative PBP binding loops; other site
378806009493	ABC-ATPase subunit interface; other site
378806009494	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
378806009495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806009496	dimer interface [polypeptide binding]; other site
378806009497	conserved gate region; other site
378806009498	putative PBP binding loops; other site
378806009499	ABC-ATPase subunit interface; other site
378806009500	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
378806009501	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
378806009502	tetrameric interface [polypeptide binding]; other site
378806009503	NAD binding site [chemical binding]; other site
378806009504	catalytic residues [active]
378806009505	substrate binding site [chemical binding]; other site
378806009506	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
378806009507	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806009508	inhibitor-cofactor binding pocket; inhibition site
378806009509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806009510	catalytic residue [active]
378806009511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
378806009512	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
378806009513	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
378806009514	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
378806009515	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
378806009516	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806009517	acyl-activating enzyme (AAE) consensus motif; other site
378806009518	active site
378806009519	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
378806009520	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
378806009521	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
378806009522	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
378806009523	Walker A/P-loop; other site
378806009524	ATP binding site [chemical binding]; other site
378806009525	Q-loop/lid; other site
378806009526	ABC transporter signature motif; other site
378806009527	Walker B; other site
378806009528	D-loop; other site
378806009529	H-loop/switch region; other site
378806009530	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
378806009531	putative carbohydrate binding site [chemical binding]; other site
378806009532	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
378806009533	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
378806009534	Probable Catalytic site; other site
378806009535	metal-binding site
378806009536	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
378806009537	active site
378806009538	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
378806009539	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
378806009540	Probable Catalytic site; other site
378806009541	metal-binding site
378806009542	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
378806009543	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
378806009544	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806009545	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806009546	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
378806009547	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
378806009548	NAD binding site [chemical binding]; other site
378806009549	substrate binding site [chemical binding]; other site
378806009550	homodimer interface [polypeptide binding]; other site
378806009551	active site
378806009552	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
378806009553	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
378806009554	NADP binding site [chemical binding]; other site
378806009555	active site
378806009556	putative substrate binding site [chemical binding]; other site
378806009557	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
378806009558	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
378806009559	substrate binding site; other site
378806009560	tetramer interface; other site
378806009561	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
378806009562	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
378806009563	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
378806009564	metal ion-dependent adhesion site (MIDAS); other site
378806009565	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806009566	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806009567	active site
378806009568	ATP binding site [chemical binding]; other site
378806009569	substrate binding site [chemical binding]; other site
378806009570	activation loop (A-loop); other site
378806009571	PEGA domain; Region: PEGA; pfam08308
378806009572	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
378806009573	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382
378806009574	UbiA prenyltransferase family; Region: UbiA; pfam01040
378806009575	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
378806009576	UbiA prenyltransferase family; Region: UbiA; pfam01040
378806009577	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
378806009578	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806009579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806009580	Walker A/P-loop; other site
378806009581	ATP binding site [chemical binding]; other site
378806009582	Q-loop/lid; other site
378806009583	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806009584	ABC transporter signature motif; other site
378806009585	Walker B; other site
378806009586	D-loop; other site
378806009587	ABC transporter; Region: ABC_tran_2; pfam12848
378806009588	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806009589	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
378806009590	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
378806009591	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
378806009592	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806009593	Predicted membrane protein [Function unknown]; Region: COG2311
378806009594	Protein of unknown function (DUF418); Region: DUF418; pfam04235
378806009595	Dihydroneopterin aldolase; Region: FolB; pfam02152
378806009596	active site
378806009597	Cupin domain; Region: Cupin_2; cl17218
378806009598	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
378806009599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806009600	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806009601	Walker A motif; other site
378806009602	ATP binding site [chemical binding]; other site
378806009603	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
378806009604	AAA-like domain; Region: AAA_10; pfam12846
378806009605	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806009606	Walker A motif; other site
378806009607	ATP binding site [chemical binding]; other site
378806009608	Walker B motif; other site
378806009609	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
378806009610	putative active site [active]
378806009611	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
378806009612	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
378806009613	Ligand binding site; other site
378806009614	DXD motif; other site
378806009615	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
378806009616	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
378806009617	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
378806009618	alanine dehydrogenase; Validated; Region: PRK06046
378806009619	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
378806009620	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
378806009621	short chain dehydrogenase; Provisional; Region: PRK06181
378806009622	NADP binding site [chemical binding]; other site
378806009623	homodimer interface [polypeptide binding]; other site
378806009624	substrate binding site [chemical binding]; other site
378806009625	active site
378806009626	DEAD-like helicases superfamily; Region: DEXDc; smart00487
378806009627	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
378806009628	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806009629	ATP binding site [chemical binding]; other site
378806009630	putative Mg++ binding site [ion binding]; other site
378806009631	helicase superfamily c-terminal domain; Region: HELICc; smart00490
378806009632	nucleotide binding region [chemical binding]; other site
378806009633	ATP-binding site [chemical binding]; other site
378806009634	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
378806009635	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806009636	Cytochrome P450; Region: p450; cl12078
378806009637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806009638	S-adenosylmethionine binding site [chemical binding]; other site
378806009639	tellurium resistance terB-like protein; Region: terB_like; cd07177
378806009640	metal binding site [ion binding]; metal-binding site
378806009641	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
378806009642	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
378806009643	intersubunit interface [polypeptide binding]; other site
378806009644	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
378806009645	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
378806009646	ABC-ATPase subunit  interface; other site
378806009647	dimer interface [polypeptide binding]; other site
378806009648	putative PBP binding regions; other site
378806009649	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
378806009650	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
378806009651	Walker A/P-loop; other site
378806009652	ATP binding site [chemical binding]; other site
378806009653	Q-loop/lid; other site
378806009654	ABC transporter signature motif; other site
378806009655	Walker B; other site
378806009656	D-loop; other site
378806009657	H-loop/switch region; other site
378806009658	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
378806009659	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806009660	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806009661	catalytic residue [active]
378806009662	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
378806009663	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806009664	putative substrate translocation pore; other site
378806009665	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806009666	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
378806009667	N-terminal plug; other site
378806009668	ligand-binding site [chemical binding]; other site
378806009669	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
378806009670	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
378806009671	Condensation domain; Region: Condensation; pfam00668
378806009672	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806009673	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
378806009674	acyl-activating enzyme (AAE) consensus motif; other site
378806009675	AMP binding site [chemical binding]; other site
378806009676	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806009677	thioester reductase domain; Region: Thioester-redct; TIGR01746
378806009678	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
378806009679	putative NAD(P) binding site [chemical binding]; other site
378806009680	active site
378806009681	putative substrate binding site [chemical binding]; other site
378806009682	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
378806009683	Isochorismatase family; Region: Isochorismatase; pfam00857
378806009684	catalytic triad [active]
378806009685	conserved cis-peptide bond; other site
378806009686	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
378806009687	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
378806009688	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
378806009689	acyl-activating enzyme (AAE) consensus motif; other site
378806009690	active site
378806009691	AMP binding site [chemical binding]; other site
378806009692	substrate binding site [chemical binding]; other site
378806009693	isochorismate synthase DhbC; Validated; Region: PRK06923
378806009694	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
378806009695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806009696	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316
378806009697	NAD(P) binding site [chemical binding]; other site
378806009698	active site
378806009699	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
378806009700	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
378806009701	FAD binding pocket [chemical binding]; other site
378806009702	FAD binding motif [chemical binding]; other site
378806009703	phosphate binding motif [ion binding]; other site
378806009704	NAD binding pocket [chemical binding]; other site
378806009705	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806009706	active site
378806009707	catalytic tetrad [active]
378806009708	methionine sulfoxide reductase B; Provisional; Region: PRK00222
378806009709	SelR domain; Region: SelR; pfam01641
378806009710	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806009711	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
378806009712	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
378806009713	tartrate dehydrogenase; Region: TTC; TIGR02089
378806009714	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
378806009715	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
378806009716	substrate binding site [chemical binding]; other site
378806009717	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
378806009718	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
378806009719	substrate binding site [chemical binding]; other site
378806009720	ligand binding site [chemical binding]; other site
378806009721	2-isopropylmalate synthase; Validated; Region: PRK00915
378806009722	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
378806009723	active site
378806009724	catalytic residues [active]
378806009725	metal binding site [ion binding]; metal-binding site
378806009726	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
378806009727	cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662
378806009728	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
378806009729	NADP binding site [chemical binding]; other site
378806009730	putative substrate binding site [chemical binding]; other site
378806009731	active site
378806009732	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
378806009733	Trp docking motif [polypeptide binding]; other site
378806009734	active site
378806009735	PQQ-like domain; Region: PQQ_2; pfam13360
378806009736	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
378806009737	AAA domain; Region: AAA_28; pfam13521
378806009738	Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655
378806009739	glycine cleavage system protein H; Provisional; Region: PRK13380
378806009740	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
378806009741	lipoyl attachment site [posttranslational modification]; other site
378806009742	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
378806009743	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806009744	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
378806009745	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
378806009746	DNA binding residues [nucleotide binding]
378806009747	putative dimer interface [polypeptide binding]; other site
378806009748	Amidase; Region: Amidase; cl11426
378806009749	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
378806009750	Zn binding site [ion binding]; other site
378806009751	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
378806009752	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806009753	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806009754	Trichodiene synthase (TRI5); Region: TRI5; pfam06330
378806009755	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
378806009756	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
378806009757	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
378806009758	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
378806009759	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
378806009760	putative active site [active]
378806009761	PhoH-like protein; Region: PhoH; pfam02562
378806009762	Protein of unknown function (DUF493); Region: DUF493; pfam04359
378806009763	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806009764	S-adenosylmethionine binding site [chemical binding]; other site
378806009765	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
378806009766	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
378806009767	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
378806009768	nucleotide binding site [chemical binding]; other site
378806009769	NEF interaction site [polypeptide binding]; other site
378806009770	SBD interface [polypeptide binding]; other site
378806009771	MoxR-like ATPases [General function prediction only]; Region: COG0714
378806009772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
378806009773	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
378806009774	metal ion-dependent adhesion site (MIDAS); other site
378806009775	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
378806009776	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
378806009777	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
378806009778	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
378806009779	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806009780	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
378806009781	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806009782	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806009783	phosphopeptide binding site; other site
378806009784	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806009785	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806009786	active site
378806009787	ATP binding site [chemical binding]; other site
378806009788	substrate binding site [chemical binding]; other site
378806009789	activation loop (A-loop); other site
378806009790	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806009791	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
378806009792	FHA domain; Region: FHA; pfam00498
378806009793	phosphopeptide binding site; other site
378806009794	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
378806009795	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806009796	Zn2+ binding site [ion binding]; other site
378806009797	Mg2+ binding site [ion binding]; other site
378806009798	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
378806009799	synthetase active site [active]
378806009800	NTP binding site [chemical binding]; other site
378806009801	metal binding site [ion binding]; metal-binding site
378806009802	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
378806009803	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
378806009804	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
378806009805	homotrimer interaction site [polypeptide binding]; other site
378806009806	putative active site [active]
378806009807	Thioredoxin; Region: Thioredoxin_4; pfam13462
378806009808	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
378806009809	Thioredoxin; Region: Thioredoxin_4; pfam13462
378806009810	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
378806009811	Thioredoxin; Region: Thioredoxin_4; pfam13462
378806009812	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
378806009813	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
378806009814	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806009815	Walker A/P-loop; other site
378806009816	ATP binding site [chemical binding]; other site
378806009817	Q-loop/lid; other site
378806009818	ABC transporter signature motif; other site
378806009819	Walker B; other site
378806009820	D-loop; other site
378806009821	H-loop/switch region; other site
378806009822	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
378806009823	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806009824	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
378806009825	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806009826	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806009827	metal binding site [ion binding]; metal-binding site
378806009828	active site
378806009829	I-site; other site
378806009830	Response regulator receiver domain; Region: Response_reg; pfam00072
378806009831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806009832	active site
378806009833	phosphorylation site [posttranslational modification]
378806009834	intermolecular recognition site; other site
378806009835	dimerization interface [polypeptide binding]; other site
378806009836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806009837	Walker A motif; other site
378806009838	ATP binding site [chemical binding]; other site
378806009839	Walker B motif; other site
378806009840	arginine finger; other site
378806009841	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806009842	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806009843	NAD(P) binding site [chemical binding]; other site
378806009844	active site
378806009845	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806009846	binding surface
378806009847	TPR repeat; Region: TPR_11; pfam13414
378806009848	TPR motif; other site
378806009849	TPR repeat; Region: TPR_11; pfam13414
378806009850	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
378806009851	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
378806009852	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
378806009853	Prephenate dehydratase; Region: PDT; pfam00800
378806009854	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
378806009855	putative L-Phe binding site [chemical binding]; other site
378806009856	Chorismate mutase type II; Region: CM_2; smart00830
378806009857	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
378806009858	Prephenate dehydratase; Region: PDT; pfam00800
378806009859	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
378806009860	putative L-Phe binding site [chemical binding]; other site
378806009861	EVE domain; Region: EVE; pfam01878
378806009862	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
378806009863	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
378806009864	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
378806009865	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
378806009866	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
378806009867	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
378806009868	catalytic site [active]
378806009869	active site
378806009870	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
378806009871	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
378806009872	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
378806009873	SLBB domain; Region: SLBB; pfam10531
378806009874	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
378806009875	AAA domain; Region: AAA_31; pfam13614
378806009876	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
378806009877	Bacterial sugar transferase; Region: Bac_transf; pfam02397
378806009878	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
378806009879	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
378806009880	phosphate binding site [ion binding]; other site
378806009881	putative substrate binding pocket [chemical binding]; other site
378806009882	dimer interface [polypeptide binding]; other site
378806009883	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
378806009884	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806009885	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
378806009886	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806009887	catalytic residue [active]
378806009888	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806009889	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
378806009890	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
378806009891	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
378806009892	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806009893	sugar binding site [chemical binding]; other site
378806009894	Predicted membrane protein [Function unknown]; Region: COG4267
378806009895	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
378806009896	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806009897	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
378806009898	GAF domain; Region: GAF_3; pfam13492
378806009899	Tetratricopeptide repeat; Region: TPR_15; pfam13429
378806009900	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
378806009901	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
378806009902	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
378806009903	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
378806009904	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
378806009905	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
378806009906	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806009907	Kelch motif; Region: Kelch_1; pfam01344
378806009908	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806009909	Kelch domain; Region: Kelch; smart00612
378806009910	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806009911	Kelch domain; Region: Kelch; smart00612
378806009912	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806009913	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806009914	Kelch domain; Region: Kelch; smart00612
378806009915	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806009916	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806009917	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806009918	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
378806009919	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
378806009920	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806009921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806009922	DNA-binding site [nucleotide binding]; DNA binding site
378806009923	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806009924	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
378806009925	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806009926	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806009927	TPR motif; other site
378806009928	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806009929	binding surface
378806009930	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
378806009931	Zn-ribbon containing protein [General function prediction only]; Region: COG3364
378806009932	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
378806009933	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806009934	catalytic residues [active]
378806009935	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
378806009936	CcmE; Region: CcmE; pfam03100
378806009937	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
378806009938	CcmB protein; Region: CcmB; cl17444
378806009939	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806009940	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
378806009941	Walker A/P-loop; other site
378806009942	ATP binding site [chemical binding]; other site
378806009943	Q-loop/lid; other site
378806009944	ABC transporter signature motif; other site
378806009945	Walker B; other site
378806009946	D-loop; other site
378806009947	H-loop/switch region; other site
378806009948	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
378806009949	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
378806009950	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
378806009951	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
378806009952	trimer interface [polypeptide binding]; other site
378806009953	active site
378806009954	substrate binding site [chemical binding]; other site
378806009955	CoA binding site [chemical binding]; other site
378806009956	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806009957	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806009958	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
378806009959	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806009960	putative homodimer interface [polypeptide binding]; other site
378806009961	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
378806009962	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
378806009963	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806009964	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806009965	active site
378806009966	ATP binding site [chemical binding]; other site
378806009967	substrate binding site [chemical binding]; other site
378806009968	activation loop (A-loop); other site
378806009969	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
378806009970	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
378806009971	active site
378806009972	dimer interface [polypeptide binding]; other site
378806009973	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
378806009974	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
378806009975	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
378806009976	oligomer interface [polypeptide binding]; other site
378806009977	metal binding site [ion binding]; metal-binding site
378806009978	metal binding site [ion binding]; metal-binding site
378806009979	putative Cl binding site [ion binding]; other site
378806009980	aspartate ring; other site
378806009981	basic sphincter; other site
378806009982	hydrophobic gate; other site
378806009983	periplasmic entrance; other site
378806009984	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
378806009985	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806009986	active site
378806009987	motif I; other site
378806009988	motif II; other site
378806009989	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
378806009990	PUA domain; Region: PUA; cl00607
378806009991	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
378806009992	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
378806009993	putative RNA binding site [nucleotide binding]; other site
378806009994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806009995	S-adenosylmethionine binding site [chemical binding]; other site
378806009996	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
378806009997	active site
378806009998	catalytic triad [active]
378806009999	CAAX protease self-immunity; Region: Abi; pfam02517
378806010000	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
378806010001	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806010002	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
378806010003	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
378806010004	putative acyl-acceptor binding pocket; other site
378806010005	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806010006	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806010007	dimer interface [polypeptide binding]; other site
378806010008	phosphorylation site [posttranslational modification]
378806010009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806010010	ATP binding site [chemical binding]; other site
378806010011	Mg2+ binding site [ion binding]; other site
378806010012	G-X-G motif; other site
378806010013	Response regulator receiver domain; Region: Response_reg; pfam00072
378806010014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806010015	active site
378806010016	phosphorylation site [posttranslational modification]
378806010017	intermolecular recognition site; other site
378806010018	dimerization interface [polypeptide binding]; other site
378806010019	HEAT repeats; Region: HEAT_2; pfam13646
378806010020	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
378806010021	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806010022	HSP70 interaction site [polypeptide binding]; other site
378806010023	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
378806010024	Zn binding sites [ion binding]; other site
378806010025	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
378806010026	dimer interface [polypeptide binding]; other site
378806010027	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
378806010028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806010029	Coenzyme A binding pocket [chemical binding]; other site
378806010030	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
378806010031	S17 interaction site [polypeptide binding]; other site
378806010032	S8 interaction site; other site
378806010033	16S rRNA interaction site [nucleotide binding]; other site
378806010034	streptomycin interaction site [chemical binding]; other site
378806010035	23S rRNA interaction site [nucleotide binding]; other site
378806010036	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
378806010037	30S ribosomal protein S7; Validated; Region: PRK05302
378806010038	elongation factor G; Reviewed; Region: PRK00007
378806010039	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
378806010040	G1 box; other site
378806010041	putative GEF interaction site [polypeptide binding]; other site
378806010042	GTP/Mg2+ binding site [chemical binding]; other site
378806010043	Switch I region; other site
378806010044	G2 box; other site
378806010045	G3 box; other site
378806010046	Switch II region; other site
378806010047	G4 box; other site
378806010048	G5 box; other site
378806010049	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
378806010050	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
378806010051	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
378806010052	elongation factor Tu; Reviewed; Region: PRK00049
378806010053	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
378806010054	G1 box; other site
378806010055	GEF interaction site [polypeptide binding]; other site
378806010056	GTP/Mg2+ binding site [chemical binding]; other site
378806010057	Switch I region; other site
378806010058	G2 box; other site
378806010059	G3 box; other site
378806010060	Switch II region; other site
378806010061	G4 box; other site
378806010062	G5 box; other site
378806010063	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
378806010064	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
378806010065	Antibiotic Binding Site [chemical binding]; other site
378806010066	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
378806010067	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
378806010068	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
378806010069	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
378806010070	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
378806010071	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
378806010072	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
378806010073	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
378806010074	putative translocon binding site; other site
378806010075	protein-rRNA interface [nucleotide binding]; other site
378806010076	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
378806010077	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
378806010078	G-X-X-G motif; other site
378806010079	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
378806010080	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
378806010081	23S rRNA interface [nucleotide binding]; other site
378806010082	5S rRNA interface [nucleotide binding]; other site
378806010083	putative antibiotic binding site [chemical binding]; other site
378806010084	L25 interface [polypeptide binding]; other site
378806010085	L27 interface [polypeptide binding]; other site
378806010086	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
378806010087	putative translocon interaction site; other site
378806010088	23S rRNA interface [nucleotide binding]; other site
378806010089	signal recognition particle (SRP54) interaction site; other site
378806010090	L23 interface [polypeptide binding]; other site
378806010091	trigger factor interaction site; other site
378806010092	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
378806010093	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
378806010094	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
378806010095	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
378806010096	RNA binding site [nucleotide binding]; other site
378806010097	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
378806010098	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
378806010099	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
378806010100	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
378806010101	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
378806010102	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
378806010103	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
378806010104	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
378806010105	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
378806010106	23S rRNA interface [nucleotide binding]; other site
378806010107	5S rRNA interface [nucleotide binding]; other site
378806010108	L27 interface [polypeptide binding]; other site
378806010109	L5 interface [polypeptide binding]; other site
378806010110	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
378806010111	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
378806010112	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
378806010113	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
378806010114	23S rRNA binding site [nucleotide binding]; other site
378806010115	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
378806010116	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
378806010117	SecY translocase; Region: SecY; pfam00344
378806010118	adenylate kinase; Reviewed; Region: adk; PRK00279
378806010119	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
378806010120	AMP-binding site [chemical binding]; other site
378806010121	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
378806010122	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
378806010123	active site
378806010124	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
378806010125	rRNA binding site [nucleotide binding]; other site
378806010126	predicted 30S ribosome binding site; other site
378806010127	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
378806010128	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
378806010129	30S ribosomal protein S13; Region: bact_S13; TIGR03631
378806010130	30S ribosomal protein S11; Validated; Region: PRK05309
378806010131	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
378806010132	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
378806010133	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806010134	RNA binding surface [nucleotide binding]; other site
378806010135	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
378806010136	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
378806010137	alphaNTD homodimer interface [polypeptide binding]; other site
378806010138	alphaNTD - beta interaction site [polypeptide binding]; other site
378806010139	alphaNTD - beta' interaction site [polypeptide binding]; other site
378806010140	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
378806010141	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
378806010142	TPR repeat; Region: TPR_11; pfam13414
378806010143	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010144	TPR motif; other site
378806010145	TPR repeat; Region: TPR_11; pfam13414
378806010146	binding surface
378806010147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010148	binding surface
378806010149	TPR motif; other site
378806010150	TPR repeat; Region: TPR_11; pfam13414
378806010151	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010152	binding surface
378806010153	TPR motif; other site
378806010154	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806010155	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
378806010156	putative acyl-acceptor binding pocket; other site
378806010157	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
378806010158	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
378806010159	Substrate-binding site [chemical binding]; other site
378806010160	Substrate specificity [chemical binding]; other site
378806010161	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
378806010162	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
378806010163	Peptidase family C69; Region: Peptidase_C69; cl17793
378806010164	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
378806010165	dimer interface [polypeptide binding]; other site
378806010166	ADP-ribose binding site [chemical binding]; other site
378806010167	active site
378806010168	nudix motif; other site
378806010169	metal binding site [ion binding]; metal-binding site
378806010170	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
378806010171	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
378806010172	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806010173	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
378806010174	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806010175	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806010176	active site
378806010177	ATP binding site [chemical binding]; other site
378806010178	substrate binding site [chemical binding]; other site
378806010179	activation loop (A-loop); other site
378806010180	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
378806010181	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806010182	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806010183	ABC transporter; Region: ABC_tran_2; pfam12848
378806010184	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806010185	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
378806010186	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
378806010187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806010188	dimer interface [polypeptide binding]; other site
378806010189	conserved gate region; other site
378806010190	ABC-ATPase subunit interface; other site
378806010191	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
378806010192	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806010193	Walker A/P-loop; other site
378806010194	ATP binding site [chemical binding]; other site
378806010195	Q-loop/lid; other site
378806010196	ABC transporter signature motif; other site
378806010197	Walker B; other site
378806010198	D-loop; other site
378806010199	H-loop/switch region; other site
378806010200	Right handed beta helix region; Region: Beta_helix; pfam13229
378806010201	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
378806010202	Integrase core domain; Region: rve; pfam00665
378806010203	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806010204	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806010205	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806010206	Phage capsid family; Region: Phage_capsid; pfam05065
378806010207	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806010208	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
378806010209	active site
378806010210	metal binding site [ion binding]; metal-binding site
378806010211	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806010212	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
378806010213	tandem repeat interface [polypeptide binding]; other site
378806010214	oligomer interface [polypeptide binding]; other site
378806010215	active site residues [active]
378806010216	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
378806010217	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
378806010218	tandem repeat interface [polypeptide binding]; other site
378806010219	oligomer interface [polypeptide binding]; other site
378806010220	active site residues [active]
378806010221	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
378806010222	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806010223	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
378806010224	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
378806010225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806010226	active site
378806010227	phosphorylation site [posttranslational modification]
378806010228	intermolecular recognition site; other site
378806010229	dimerization interface [polypeptide binding]; other site
378806010230	CheB methylesterase; Region: CheB_methylest; pfam01339
378806010231	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806010232	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806010233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806010234	phosphorylation site [posttranslational modification]
378806010235	dimer interface [polypeptide binding]; other site
378806010236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806010237	ATP binding site [chemical binding]; other site
378806010238	Mg2+ binding site [ion binding]; other site
378806010239	G-X-G motif; other site
378806010240	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
378806010241	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806010242	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806010243	catalytic residue [active]
378806010244	seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474
378806010245	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
378806010246	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
378806010247	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
378806010248	active site
378806010249	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
378806010250	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
378806010251	DnaJ domain; Region: DnaJ; pfam00226
378806010252	HSP70 interaction site [polypeptide binding]; other site
378806010253	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806010254	non-specific DNA binding site [nucleotide binding]; other site
378806010255	salt bridge; other site
378806010256	sequence-specific DNA binding site [nucleotide binding]; other site
378806010257	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
378806010258	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806010259	active site
378806010260	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
378806010261	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
378806010262	Ca binding site [ion binding]; other site
378806010263	active site
378806010264	catalytic site [active]
378806010265	hypothetical protein; Provisional; Region: PRK02237
378806010266	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
378806010267	active site
378806010268	catalytic triad [active]
378806010269	oxyanion hole [active]
378806010270	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
378806010271	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806010272	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806010273	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
378806010274	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
378806010275	OPT oligopeptide transporter protein; Region: OPT; cl14607
378806010276	OPT oligopeptide transporter protein; Region: OPT; cl14607
378806010277	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
378806010278	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
378806010279	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806010280	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
378806010281	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806010282	DNA binding residues [nucleotide binding]
378806010283	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
378806010284	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
378806010285	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
378806010286	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
378806010287	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
378806010288	Protein of unknown function DUF58; Region: DUF58; pfam01882
378806010289	MoxR-like ATPases [General function prediction only]; Region: COG0714
378806010290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806010291	Walker A motif; other site
378806010292	ATP binding site [chemical binding]; other site
378806010293	Walker B motif; other site
378806010294	arginine finger; other site
378806010295	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
378806010296	anti sigma factor interaction site; other site
378806010297	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
378806010298	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806010299	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806010300	catalytic residue [active]
378806010301	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
378806010302	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
378806010303	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
378806010304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010305	binding surface
378806010306	TPR motif; other site
378806010307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010308	TPR motif; other site
378806010309	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806010310	binding surface
378806010311	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806010312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010313	binding surface
378806010314	TPR motif; other site
378806010315	TPR repeat; Region: TPR_11; pfam13414
378806010316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010317	binding surface
378806010318	TPR motif; other site
378806010319	TPR repeat; Region: TPR_11; pfam13414
378806010320	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010321	binding surface
378806010322	TPR motif; other site
378806010323	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806010324	phosphopeptide binding site; other site
378806010325	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
378806010326	Response regulator receiver domain; Region: Response_reg; pfam00072
378806010327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806010328	active site
378806010329	phosphorylation site [posttranslational modification]
378806010330	intermolecular recognition site; other site
378806010331	dimerization interface [polypeptide binding]; other site
378806010332	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
378806010333	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
378806010334	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
378806010335	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
378806010336	Phosphotransferase enzyme family; Region: APH; pfam01636
378806010337	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010338	TPR motif; other site
378806010339	binding surface
378806010340	TPR repeat; Region: TPR_11; pfam13414
378806010341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010342	binding surface
378806010343	TPR motif; other site
378806010344	TPR repeat; Region: TPR_11; pfam13414
378806010345	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010346	binding surface
378806010347	TPR motif; other site
378806010348	TPR repeat; Region: TPR_11; pfam13414
378806010349	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010350	binding surface
378806010351	TPR motif; other site
378806010352	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
378806010353	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
378806010354	G1 box; other site
378806010355	putative GEF interaction site [polypeptide binding]; other site
378806010356	GTP/Mg2+ binding site [chemical binding]; other site
378806010357	Switch I region; other site
378806010358	G2 box; other site
378806010359	G3 box; other site
378806010360	Switch II region; other site
378806010361	G4 box; other site
378806010362	G5 box; other site
378806010363	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
378806010364	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
378806010365	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806010366	TAP-like protein; Region: Abhydrolase_4; pfam08386
378806010367	Sensory domain found in PocR; Region: PocR; pfam10114
378806010368	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806010369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806010370	Walker A motif; other site
378806010371	ATP binding site [chemical binding]; other site
378806010372	Walker B motif; other site
378806010373	arginine finger; other site
378806010374	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806010375	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
378806010376	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
378806010377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806010378	S-adenosylmethionine binding site [chemical binding]; other site
378806010379	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
378806010380	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
378806010381	active site
378806010382	(T/H)XGH motif; other site
378806010383	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
378806010384	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
378806010385	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
378806010386	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
378806010387	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
378806010388	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806010389	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
378806010390	IMP binding site; other site
378806010391	dimer interface [polypeptide binding]; other site
378806010392	interdomain contacts; other site
378806010393	partial ornithine binding site; other site
378806010394	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
378806010395	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
378806010396	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
378806010397	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
378806010398	Glyco_18 domain; Region: Glyco_18; smart00636
378806010399	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
378806010400	active site
378806010401	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
378806010402	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806010403	Helix-turn-helix domain; Region: HTH_18; pfam12833
378806010404	Prostaglandin dehydrogenases; Region: PGDH; cd05288
378806010405	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
378806010406	NAD(P) binding site [chemical binding]; other site
378806010407	substrate binding site [chemical binding]; other site
378806010408	dimer interface [polypeptide binding]; other site
378806010409	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
378806010410	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
378806010411	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
378806010412	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
378806010413	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
378806010414	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806010415	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806010416	putative sugar binding sites [chemical binding]; other site
378806010417	Q-X-W motif; other site
378806010418	Protein of unknown function (DUF466); Region: DUF466; pfam04328
378806010419	carbon starvation protein A; Provisional; Region: PRK15015
378806010420	Carbon starvation protein CstA; Region: CstA; pfam02554
378806010421	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
378806010422	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
378806010423	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806010424	ATP binding site [chemical binding]; other site
378806010425	putative Mg++ binding site [ion binding]; other site
378806010426	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806010427	nucleotide binding region [chemical binding]; other site
378806010428	ATP-binding site [chemical binding]; other site
378806010429	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806010430	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
378806010431	active site
378806010432	catalytic triad [active]
378806010433	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806010434	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
378806010435	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806010436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806010437	dimer interface [polypeptide binding]; other site
378806010438	phosphorylation site [posttranslational modification]
378806010439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806010440	ATP binding site [chemical binding]; other site
378806010441	Mg2+ binding site [ion binding]; other site
378806010442	G-X-G motif; other site
378806010443	Response regulator receiver domain; Region: Response_reg; pfam00072
378806010444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806010445	active site
378806010446	phosphorylation site [posttranslational modification]
378806010447	intermolecular recognition site; other site
378806010448	dimerization interface [polypeptide binding]; other site
378806010449	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806010450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806010451	dimer interface [polypeptide binding]; other site
378806010452	phosphorylation site [posttranslational modification]
378806010453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806010454	ATP binding site [chemical binding]; other site
378806010455	Mg2+ binding site [ion binding]; other site
378806010456	G-X-G motif; other site
378806010457	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
378806010458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806010459	S-adenosylmethionine binding site [chemical binding]; other site
378806010460	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
378806010461	AAA domain; Region: AAA_30; pfam13604
378806010462	Family description; Region: UvrD_C_2; pfam13538
378806010463	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
378806010464	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
378806010465	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
378806010466	Putative esterase; Region: Esterase; pfam00756
378806010467	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
378806010468	EamA-like transporter family; Region: EamA; pfam00892
378806010469	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010470	binding surface
378806010471	TPR motif; other site
378806010472	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806010473	binding surface
378806010474	TPR motif; other site
378806010475	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806010476	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
378806010477	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
378806010478	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
378806010479	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
378806010480	active site
378806010481	dimer interface [polypeptide binding]; other site
378806010482	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
378806010483	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
378806010484	active site
378806010485	FMN binding site [chemical binding]; other site
378806010486	substrate binding site [chemical binding]; other site
378806010487	3Fe-4S cluster binding site [ion binding]; other site
378806010488	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
378806010489	domain interface; other site
378806010490	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
378806010491	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
378806010492	haloalkane dehalogenase; Provisional; Region: PRK03592
378806010493	Predicted transporter component [General function prediction only]; Region: COG2391
378806010494	Sulphur transport; Region: Sulf_transp; pfam04143
378806010495	Predicted transporter component [General function prediction only]; Region: COG2391
378806010496	CsbD-like; Region: CsbD; pfam05532
378806010497	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806010498	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806010499	ligand binding site [chemical binding]; other site
378806010500	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806010501	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806010502	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
378806010503	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
378806010504	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806010505	active site
378806010506	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
378806010507	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
378806010508	active site
378806010509	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
378806010510	Ligand Binding Site [chemical binding]; other site
378806010511	Molecular Tunnel; other site
378806010512	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
378806010513	hypothetical protein; Provisional; Region: PRK06154
378806010514	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
378806010515	PYR/PP interface [polypeptide binding]; other site
378806010516	dimer interface [polypeptide binding]; other site
378806010517	TPP binding site [chemical binding]; other site
378806010518	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
378806010519	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
378806010520	TPP-binding site; other site
378806010521	dimer interface [polypeptide binding]; other site
378806010522	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806010523	PBP superfamily domain; Region: PBP_like_2; cl17296
378806010524	large tegument protein UL36; Provisional; Region: PHA03247
378806010525	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806010526	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806010527	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806010528	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806010529	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806010530	hypothetical protein; Provisional; Region: PRK07236
378806010531	FAD binding domain; Region: FAD_binding_3; pfam01494
378806010532	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806010533	tetracycline repressor protein TetR; Provisional; Region: PRK13756
378806010534	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806010535	hypothetical protein; Validated; Region: PRK05868
378806010536	hypothetical protein; Provisional; Region: PRK07236
378806010537	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806010538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806010539	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
378806010540	dimerization interface [polypeptide binding]; other site
378806010541	substrate binding pocket [chemical binding]; other site
378806010542	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806010543	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806010544	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806010545	Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional...; Region: EGF; cd00053
378806010546	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
378806010547	Lamin Tail Domain; Region: LTD; pfam00932
378806010548	hypothetical protein; Provisional; Region: PRK08317
378806010549	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806010550	S-adenosylmethionine binding site [chemical binding]; other site
378806010551	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
378806010552	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806010553	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806010554	non-specific DNA binding site [nucleotide binding]; other site
378806010555	salt bridge; other site
378806010556	sequence-specific DNA binding site [nucleotide binding]; other site
378806010557	Transposase domain (DUF772); Region: DUF772; pfam05598
378806010558	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806010559	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
378806010560	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806010561	active site
378806010562	ATP binding site [chemical binding]; other site
378806010563	substrate binding site [chemical binding]; other site
378806010564	activation loop (A-loop); other site
378806010565	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806010566	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806010567	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806010568	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806010569	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
378806010570	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
378806010571	putative active site [active]
378806010572	putative NTP binding site [chemical binding]; other site
378806010573	putative nucleic acid binding site [nucleotide binding]; other site
378806010574	Transposase domain (DUF772); Region: DUF772; pfam05598
378806010575	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806010576	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
378806010577	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806010578	nucleotide binding region [chemical binding]; other site
378806010579	ATP-binding site [chemical binding]; other site
378806010580	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
378806010581	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
378806010582	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
378806010583	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
378806010584	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
378806010585	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806010586	PGAP1-like protein; Region: PGAP1; pfam07819
378806010587	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806010588	Zn2+ binding site [ion binding]; other site
378806010589	Mg2+ binding site [ion binding]; other site
378806010590	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
378806010591	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
378806010592	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
378806010593	putative active site [active]
378806010594	putative metal binding site [ion binding]; other site
378806010595	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
378806010596	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806010597	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
378806010598	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806010599	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806010600	phosphopeptide binding site; other site
378806010601	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806010602	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806010603	phosphopeptide binding site; other site
378806010604	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
378806010605	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
378806010606	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
378806010607	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
378806010608	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
378806010609	ssDNA binding site; other site
378806010610	generic binding surface II; other site
378806010611	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806010612	ATP binding site [chemical binding]; other site
378806010613	putative Mg++ binding site [ion binding]; other site
378806010614	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806010615	nucleotide binding region [chemical binding]; other site
378806010616	ATP-binding site [chemical binding]; other site
378806010617	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
378806010618	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806010619	S-adenosylmethionine binding site [chemical binding]; other site
378806010620	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
378806010621	threonine synthase; Region: PLN02569
378806010622	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
378806010623	homodimer interface [polypeptide binding]; other site
378806010624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806010625	catalytic residue [active]
378806010626	thymidylate kinase; Region: DTMP_kinase; TIGR00041
378806010627	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
378806010628	TMP-binding site; other site
378806010629	ATP-binding site [chemical binding]; other site
378806010630	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
378806010631	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
378806010632	MPT binding site; other site
378806010633	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
378806010634	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
378806010635	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806010636	binding surface
378806010637	TPR motif; other site
378806010638	putative oxidoreductase; Provisional; Region: PRK11579
378806010639	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806010640	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
378806010641	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
378806010642	putative active site [active]
378806010643	nucleotide binding site [chemical binding]; other site
378806010644	nudix motif; other site
378806010645	putative metal binding site [ion binding]; other site
378806010646	Protein of unknown function (DUF3185); Region: DUF3185; pfam11381
378806010647	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806010648	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806010649	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806010650	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
378806010651	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
378806010652	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806010653	metal binding site [ion binding]; metal-binding site
378806010654	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806010655	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
378806010656	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239
378806010657	putative active site [active]
378806010658	Zn binding site [ion binding]; other site
378806010659	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
378806010660	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
378806010661	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
378806010662	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
378806010663	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806010664	active site
378806010665	ATP binding site [chemical binding]; other site
378806010666	substrate binding site [chemical binding]; other site
378806010667	activation loop (A-loop); other site
378806010668	Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535
378806010669	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806010670	active site
378806010671	ATP binding site [chemical binding]; other site
378806010672	substrate binding site [chemical binding]; other site
378806010673	activation loop (A-loop); other site
378806010674	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
378806010675	nucleotide binding site/active site [active]
378806010676	HIT family signature motif; other site
378806010677	catalytic residue [active]
378806010678	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
378806010679	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
378806010680	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
378806010681	classical (c) SDRs; Region: SDR_c; cd05233
378806010682	NAD(P) binding site [chemical binding]; other site
378806010683	active site
378806010684	tyramine oxidase; Provisional; Region: tynA; PRK11504
378806010685	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
378806010686	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
378806010687	potential frameshift: common BLAST hit: gi|220915455|ref|YP_002490759.1| transcriptional regulator, LysR family
378806010688	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
378806010689	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806010690	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
378806010691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
378806010692	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
378806010693	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
378806010694	putative metal binding site [ion binding]; other site
378806010695	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
378806010696	putative metal binding site [ion binding]; other site
378806010697	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
378806010698	putative metal binding site [ion binding]; other site
378806010699	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
378806010700	putative metal binding site [ion binding]; other site
378806010701	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
378806010702	Transposase domain (DUF772); Region: DUF772; pfam05598
378806010703	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806010704	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
378806010705	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806010706	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806010707	active site
378806010708	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010709	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806010710	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806010711	KR domain; Region: KR; pfam08659
378806010712	putative NADP binding site [chemical binding]; other site
378806010713	active site
378806010714	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010715	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
378806010716	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806010717	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806010718	active site
378806010719	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010720	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806010721	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806010722	KR domain; Region: KR; pfam08659
378806010723	putative NADP binding site [chemical binding]; other site
378806010724	active site
378806010725	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010726	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806010727	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806010728	active site
378806010729	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010730	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806010731	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806010732	KR domain; Region: KR; pfam08659
378806010733	putative NADP binding site [chemical binding]; other site
378806010734	active site
378806010735	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010736	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010737	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806010738	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806010739	active site
378806010740	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010741	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806010742	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010743	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806010744	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806010745	KR domain; Region: KR; pfam08659
378806010746	putative NADP binding site [chemical binding]; other site
378806010747	active site
378806010748	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010749	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
378806010750	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
378806010751	putative sugar binding site [chemical binding]; other site
378806010752	catalytic residues [active]
378806010753	GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323
378806010754	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
378806010755	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
378806010756	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
378806010757	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806010758	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806010759	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
378806010760	active sites [active]
378806010761	tetramer interface [polypeptide binding]; other site
378806010762	aspartate kinase; Reviewed; Region: PRK06635
378806010763	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
378806010764	putative nucleotide binding site [chemical binding]; other site
378806010765	putative catalytic residues [active]
378806010766	putative Mg ion binding site [ion binding]; other site
378806010767	putative aspartate binding site [chemical binding]; other site
378806010768	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
378806010769	putative allosteric regulatory site; other site
378806010770	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
378806010771	putative allosteric regulatory residue; other site
378806010772	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
378806010773	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
378806010774	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
378806010775	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
378806010776	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
378806010777	DXD motif; other site
378806010778	NlpC/P60 family; Region: NLPC_P60; cl17555
378806010779	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
378806010780	Part of AAA domain; Region: AAA_19; pfam13245
378806010781	Family description; Region: UvrD_C_2; pfam13538
378806010782	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806010783	rod shape-determining protein MreB; Provisional; Region: PRK13930
378806010784	nucleotide binding site [chemical binding]; other site
378806010785	SCP-2 sterol transfer family; Region: SCP2; cl01225
378806010786	Caspase domain; Region: Peptidase_C14; pfam00656
378806010787	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806010788	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806010789	putative sugar binding sites [chemical binding]; other site
378806010790	Q-X-W motif; other site
378806010791	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
378806010792	putative sugar binding site [chemical binding]; other site
378806010793	catalytic residues [active]
378806010794	Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474
378806010795	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806010796	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
378806010797	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
378806010798	iron-sulfur cluster [ion binding]; other site
378806010799	[2Fe-2S] cluster binding site [ion binding]; other site
378806010800	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
378806010801	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
378806010802	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
378806010803	DXD motif; other site
378806010804	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
378806010805	Kelch motif; Region: Kelch_6; pfam13964
378806010806	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806010807	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806010808	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
378806010809	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
378806010810	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
378806010811	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
378806010812	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010813	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806010814	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806010815	active site
378806010816	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806010817	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010818	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806010819	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010820	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806010821	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806010822	KR domain; Region: KR; pfam08659
378806010823	putative NADP binding site [chemical binding]; other site
378806010824	active site
378806010825	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010826	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806010827	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806010828	active site
378806010829	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806010830	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010831	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806010832	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806010833	putative NADP binding site [chemical binding]; other site
378806010834	KR domain; Region: KR; pfam08659
378806010835	active site
378806010836	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010837	Condensation domain; Region: Condensation; pfam00668
378806010838	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806010839	Nonribosomal peptide synthase; Region: NRPS; pfam08415
378806010840	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
378806010841	acyl-activating enzyme (AAE) consensus motif; other site
378806010842	AMP binding site [chemical binding]; other site
378806010843	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806010844	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
378806010845	putative FMN binding site [chemical binding]; other site
378806010846	NADPH bind site [chemical binding]; other site
378806010847	Condensation domain; Region: Condensation; pfam00668
378806010848	Nonribosomal peptide synthase; Region: NRPS; pfam08415
378806010849	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
378806010850	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
378806010851	acyl-activating enzyme (AAE) consensus motif; other site
378806010852	AMP binding site [chemical binding]; other site
378806010853	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
378806010854	putative FMN binding site [chemical binding]; other site
378806010855	NADPH bind site [chemical binding]; other site
378806010856	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806010857	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806010858	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806010859	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806010860	active site
378806010861	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010862	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806010863	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806010864	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806010865	putative NADP binding site [chemical binding]; other site
378806010866	active site
378806010867	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010868	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806010869	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806010870	active site
378806010871	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806010872	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010873	Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828
378806010874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806010875	S-adenosylmethionine binding site [chemical binding]; other site
378806010876	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806010877	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806010878	putative NADP binding site [chemical binding]; other site
378806010879	active site
378806010880	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010881	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806010882	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806010883	active site
378806010884	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806010885	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806010886	Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828
378806010887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806010888	S-adenosylmethionine binding site [chemical binding]; other site
378806010889	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806010890	Condensation domain; Region: Condensation; pfam00668
378806010891	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806010892	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806010893	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806010894	acyl-activating enzyme (AAE) consensus motif; other site
378806010895	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
378806010896	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
378806010897	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
378806010898	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806010899	AMP binding site [chemical binding]; other site
378806010900	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806010901	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
378806010902	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
378806010903	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
378806010904	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
378806010905	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
378806010906	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
378806010907	active site
378806010908	NTP binding site [chemical binding]; other site
378806010909	metal binding triad [ion binding]; metal-binding site
378806010910	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
378806010911	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
378806010912	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
378806010913	Ligand Binding Site [chemical binding]; other site
378806010914	Sporulation related domain; Region: SPOR; pfam05036
378806010915	Cupin domain; Region: Cupin_2; cl17218
378806010916	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
378806010917	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806010918	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
378806010919	NAD binding site [chemical binding]; other site
378806010920	putative substrate binding site 2 [chemical binding]; other site
378806010921	putative substrate binding site 1 [chemical binding]; other site
378806010922	active site
378806010923	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806010924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806010925	NAD(P) binding site [chemical binding]; other site
378806010926	active site
378806010927	GTP-binding protein LepA; Provisional; Region: PRK05433
378806010928	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
378806010929	G1 box; other site
378806010930	putative GEF interaction site [polypeptide binding]; other site
378806010931	GTP/Mg2+ binding site [chemical binding]; other site
378806010932	Switch I region; other site
378806010933	G2 box; other site
378806010934	G3 box; other site
378806010935	Switch II region; other site
378806010936	G4 box; other site
378806010937	G5 box; other site
378806010938	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
378806010939	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
378806010940	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
378806010941	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
378806010942	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
378806010943	Catalytic site [active]
378806010944	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
378806010945	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
378806010946	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
378806010947	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
378806010948	dihydroorotase; Validated; Region: pyrC; PRK09357
378806010949	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806010950	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
378806010951	active site
378806010952	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
378806010953	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
378806010954	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
378806010955	catalytic site [active]
378806010956	subunit interface [polypeptide binding]; other site
378806010957	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
378806010958	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
378806010959	domain interfaces; other site
378806010960	active site
378806010961	Bifunctional nuclease; Region: DNase-RNase; pfam02577
378806010962	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
378806010963	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806010964	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
378806010965	acyl-activating enzyme (AAE) consensus motif; other site
378806010966	putative AMP binding site [chemical binding]; other site
378806010967	putative active site [active]
378806010968	putative CoA binding site [chemical binding]; other site
378806010969	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
378806010970	Citrate synthase; Region: Citrate_synt; pfam00285
378806010971	oxalacetate binding site [chemical binding]; other site
378806010972	citrylCoA binding site [chemical binding]; other site
378806010973	coenzyme A binding site [chemical binding]; other site
378806010974	catalytic triad [active]
378806010975	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
378806010976	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
378806010977	putative active site [active]
378806010978	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
378806010979	active site
378806010980	NAD binding site [chemical binding]; other site
378806010981	metal binding site [ion binding]; metal-binding site
378806010982	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
378806010983	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
378806010984	Tetramer interface [polypeptide binding]; other site
378806010985	active site
378806010986	FMN-binding site [chemical binding]; other site
378806010987	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
378806010988	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
378806010989	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
378806010990	active site
378806010991	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
378806010992	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
378806010993	dimer interface [polypeptide binding]; other site
378806010994	tetramer interface [polypeptide binding]; other site
378806010995	PYR/PP interface [polypeptide binding]; other site
378806010996	TPP binding site [chemical binding]; other site
378806010997	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
378806010998	TPP-binding site; other site
378806010999	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
378806011000	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
378806011001	UbiA prenyltransferase family; Region: UbiA; pfam01040
378806011002	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
378806011003	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
378806011004	metal binding site [ion binding]; metal-binding site
378806011005	Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378
378806011006	substrate binding pocket [chemical binding]; other site
378806011007	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
378806011008	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
378806011009	acyl-activating enzyme (AAE) consensus motif; other site
378806011010	putative AMP binding site [chemical binding]; other site
378806011011	putative active site [active]
378806011012	putative CoA binding site [chemical binding]; other site
378806011013	isocitrate dehydrogenase; Validated; Region: PRK07362
378806011014	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
378806011015	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
378806011016	malate dehydrogenase; Reviewed; Region: PRK06223
378806011017	dimer interface [polypeptide binding]; other site
378806011018	NAD(P) binding site [chemical binding]; other site
378806011019	tetramer (dimer of dimers) interface [polypeptide binding]; other site
378806011020	substrate binding site [chemical binding]; other site
378806011021	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
378806011022	L-aspartate oxidase; Provisional; Region: PRK06175
378806011023	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
378806011024	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
378806011025	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
378806011026	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
378806011027	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
378806011028	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
378806011029	CoA-ligase; Region: Ligase_CoA; pfam00549
378806011030	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
378806011031	CoA binding domain; Region: CoA_binding; pfam02629
378806011032	CoA-ligase; Region: Ligase_CoA; pfam00549
378806011033	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
378806011034	active site
378806011035	multimer interface [polypeptide binding]; other site
378806011036	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806011037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806011038	LysR substrate binding domain; Region: LysR_substrate; pfam03466
378806011039	dimerization interface [polypeptide binding]; other site
378806011040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
378806011041	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
378806011042	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
378806011043	active site
378806011044	Isochorismatase family; Region: Isochorismatase; pfam00857
378806011045	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
378806011046	catalytic triad [active]
378806011047	dimer interface [polypeptide binding]; other site
378806011048	conserved cis-peptide bond; other site
378806011049	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
378806011050	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806011051	FeS/SAM binding site; other site
378806011052	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
378806011053	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
378806011054	KH domain; Region: KH_4; pfam13083
378806011055	G-X-X-G motif; other site
378806011056	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
378806011057	RimM N-terminal domain; Region: RimM; pfam01782
378806011058	PRC-barrel domain; Region: PRC; pfam05239
378806011059	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
378806011060	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
378806011061	AAA domain; Region: AAA_27; pfam13514
378806011062	hypothetical protein; Reviewed; Region: PRK12497
378806011063	Predicted methyltransferases [General function prediction only]; Region: COG0313
378806011064	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
378806011065	putative SAM binding site [chemical binding]; other site
378806011066	putative homodimer interface [polypeptide binding]; other site
378806011067	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
378806011068	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806011069	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806011070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806011071	active site
378806011072	phosphorylation site [posttranslational modification]
378806011073	intermolecular recognition site; other site
378806011074	dimerization interface [polypeptide binding]; other site
378806011075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806011076	Walker A motif; other site
378806011077	ATP binding site [chemical binding]; other site
378806011078	Walker B motif; other site
378806011079	arginine finger; other site
378806011080	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806011081	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
378806011082	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
378806011083	diiron binding motif [ion binding]; other site
378806011084	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
378806011085	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
378806011086	30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806
378806011087	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
378806011088	RNA binding site [nucleotide binding]; other site
378806011089	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
378806011090	RNA binding site [nucleotide binding]; other site
378806011091	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
378806011092	RNA binding site [nucleotide binding]; other site
378806011093	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
378806011094	RNA binding site [nucleotide binding]; other site
378806011095	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
378806011096	RNA binding site [nucleotide binding]; other site
378806011097	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
378806011098	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
378806011099	putative NAD(P) binding site [chemical binding]; other site
378806011100	active site
378806011101	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879
378806011102	polyphosphate kinase; Provisional; Region: PRK05443
378806011103	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
378806011104	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
378806011105	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
378806011106	putative domain interface [polypeptide binding]; other site
378806011107	putative active site [active]
378806011108	catalytic site [active]
378806011109	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
378806011110	putative domain interface [polypeptide binding]; other site
378806011111	putative active site [active]
378806011112	catalytic site [active]
378806011113	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806011114	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806011115	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
378806011116	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806011117	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
378806011118	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
378806011119	active site
378806011120	DNA binding site [nucleotide binding]
378806011121	Int/Topo IB signature motif; other site
378806011122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
378806011123	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
378806011124	ATPase involved in DNA repair; Region: DUF3686; pfam12458
378806011125	AAA domain; Region: AAA_22; pfam13401
378806011126	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806011127	Walker A motif; other site
378806011128	ATP binding site [chemical binding]; other site
378806011129	Walker B motif; other site
378806011130	arginine finger; other site
378806011131	Domain of unknown function (DUF336); Region: DUF336; cl01249
378806011132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806011133	ATP binding site [chemical binding]; other site
378806011134	Mg2+ binding site [ion binding]; other site
378806011135	G-X-G motif; other site
378806011136	Uncharacterized conserved protein [Function unknown]; Region: COG3287
378806011137	FIST N domain; Region: FIST; pfam08495
378806011138	FIST C domain; Region: FIST_C; pfam10442
378806011139	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
378806011140	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
378806011141	Isochorismatase family; Region: Isochorismatase; pfam00857
378806011142	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
378806011143	catalytic triad [active]
378806011144	conserved cis-peptide bond; other site
378806011145	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
378806011146	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
378806011147	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806011148	NAD(P) binding site [chemical binding]; other site
378806011149	active site
378806011150	metabolite-proton symporter; Region: 2A0106; TIGR00883
378806011151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806011152	putative substrate translocation pore; other site
378806011153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806011154	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806011155	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806011156	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806011157	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806011158	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806011159	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806011160	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
378806011161	adenylate kinase; Region: adk; TIGR01351
378806011162	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
378806011163	AMP-binding site [chemical binding]; other site
378806011164	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
378806011165	Phosphotransferase enzyme family; Region: APH; pfam01636
378806011166	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
378806011167	active site
378806011168	ATP binding site [chemical binding]; other site
378806011169	substrate binding site [chemical binding]; other site
378806011170	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806011171	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806011172	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806011173	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806011174	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806011175	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
378806011176	protein binding site [polypeptide binding]; other site
378806011177	RecX family; Region: RecX; pfam02631
378806011178	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
378806011179	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806011180	catalytic residues [active]
378806011181	LysR family transcriptional regulator; Provisional; Region: PRK14997
378806011182	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
378806011183	putative effector binding pocket; other site
378806011184	dimerization interface [polypeptide binding]; other site
378806011185	von Willebrand factor; Region: vWF_A; pfam12450
378806011186	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
378806011187	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
378806011188	metal ion-dependent adhesion site (MIDAS); other site
378806011189	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
378806011190	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
378806011191	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
378806011192	active site
378806011193	Zn binding site [ion binding]; other site
378806011194	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
378806011195	DNA-binding site [nucleotide binding]; DNA binding site
378806011196	RNA-binding motif; other site
378806011197	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806011198	Zn binding site [ion binding]; other site
378806011199	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
378806011200	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
378806011201	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
378806011202	PilZ domain; Region: PilZ; pfam07238
378806011203	LPP20 lipoprotein; Region: LPP20; pfam02169
378806011204	PEGA domain; Region: PEGA; pfam08308
378806011205	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
378806011206	Fe-S cluster binding site [ion binding]; other site
378806011207	DNA binding site [nucleotide binding]
378806011208	active site
378806011209	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
378806011210	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
378806011211	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
378806011212	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
378806011213	active site
378806011214	dimer interface [polypeptide binding]; other site
378806011215	motif 1; other site
378806011216	motif 2; other site
378806011217	motif 3; other site
378806011218	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
378806011219	anticodon binding site; other site
378806011220	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
378806011221	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
378806011222	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
378806011223	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
378806011224	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
378806011225	23S rRNA binding site [nucleotide binding]; other site
378806011226	L21 binding site [polypeptide binding]; other site
378806011227	L13 binding site [polypeptide binding]; other site
378806011228	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
378806011229	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
378806011230	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
378806011231	dimer interface [polypeptide binding]; other site
378806011232	motif 1; other site
378806011233	active site
378806011234	motif 2; other site
378806011235	motif 3; other site
378806011236	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
378806011237	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
378806011238	putative tRNA-binding site [nucleotide binding]; other site
378806011239	B3/4 domain; Region: B3_4; pfam03483
378806011240	tRNA synthetase B5 domain; Region: B5; smart00874
378806011241	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
378806011242	dimer interface [polypeptide binding]; other site
378806011243	motif 1; other site
378806011244	motif 3; other site
378806011245	motif 2; other site
378806011246	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
378806011247	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
378806011248	IHF dimer interface [polypeptide binding]; other site
378806011249	IHF - DNA interface [nucleotide binding]; other site
378806011250	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
378806011251	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
378806011252	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806011253	Walker A/P-loop; other site
378806011254	ATP binding site [chemical binding]; other site
378806011255	Q-loop/lid; other site
378806011256	ABC transporter signature motif; other site
378806011257	Walker B; other site
378806011258	D-loop; other site
378806011259	H-loop/switch region; other site
378806011260	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806011261	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806011262	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
378806011263	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
378806011264	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
378806011265	sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678
378806011266	FAD binding domain; Region: FAD_binding_4; pfam01565
378806011267	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
378806011268	Domain of unknown function (DUF697); Region: DUF697; cl12064
378806011269	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
378806011270	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
378806011271	Cupin superfamily protein; Region: Cupin_4; pfam08007
378806011272	Cupin superfamily protein; Region: Cupin_4; pfam08007
378806011273	Cupin-like domain; Region: Cupin_8; pfam13621
378806011274	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
378806011275	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
378806011276	active site
378806011277	zinc binding site [ion binding]; other site
378806011278	Peptidase family S41; Region: Peptidase_S41; pfam03572
378806011279	Active site serine [active]
378806011280	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
378806011281	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
378806011282	substrate binding pocket [chemical binding]; other site
378806011283	chain length determination region; other site
378806011284	substrate-Mg2+ binding site; other site
378806011285	catalytic residues [active]
378806011286	aspartate-rich region 1; other site
378806011287	active site lid residues [active]
378806011288	aspartate-rich region 2; other site
378806011289	bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975
378806011290	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
378806011291	B12 binding site [chemical binding]; other site
378806011292	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806011293	FeS/SAM binding site; other site
378806011294	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
378806011295	FtsX-like permease family; Region: FtsX; pfam02687
378806011296	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806011297	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806011298	NAD(P) binding site [chemical binding]; other site
378806011299	active site
378806011300	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806011301	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
378806011302	Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843
378806011303	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
378806011304	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806011305	FtsX-like permease family; Region: FtsX; pfam02687
378806011306	peptide synthase; Provisional; Region: PRK12316
378806011307	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806011308	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806011309	acyl-activating enzyme (AAE) consensus motif; other site
378806011310	AMP binding site [chemical binding]; other site
378806011311	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011312	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
378806011313	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806011314	acyl-activating enzyme (AAE) consensus motif; other site
378806011315	AMP binding site [chemical binding]; other site
378806011316	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011317	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806011318	acyl-activating enzyme (AAE) consensus motif; other site
378806011319	AMP binding site [chemical binding]; other site
378806011320	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011321	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
378806011322	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806011323	acyl-activating enzyme (AAE) consensus motif; other site
378806011324	AMP binding site [chemical binding]; other site
378806011325	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011326	Condensation domain; Region: Condensation; pfam00668
378806011327	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806011328	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806011329	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806011330	acyl-activating enzyme (AAE) consensus motif; other site
378806011331	AMP binding site [chemical binding]; other site
378806011332	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011333	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806011334	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806011335	active site
378806011336	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806011337	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806011338	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
378806011339	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806011340	putative NADP binding site [chemical binding]; other site
378806011341	active site
378806011342	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011343	Condensation domain; Region: Condensation; pfam00668
378806011344	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806011345	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806011346	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806011347	acyl-activating enzyme (AAE) consensus motif; other site
378806011348	AMP binding site [chemical binding]; other site
378806011349	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011350	Condensation domain; Region: Condensation; pfam00668
378806011351	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806011352	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806011353	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806011354	acyl-activating enzyme (AAE) consensus motif; other site
378806011355	AMP binding site [chemical binding]; other site
378806011356	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011357	Condensation domain; Region: Condensation; pfam00668
378806011358	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806011359	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806011360	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806011361	acyl-activating enzyme (AAE) consensus motif; other site
378806011362	AMP binding site [chemical binding]; other site
378806011363	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011364	Condensation domain; Region: Condensation; pfam00668
378806011365	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806011366	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806011367	H+ Antiporter protein; Region: 2A0121; TIGR00900
378806011368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806011369	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
378806011370	Amidase; Region: Amidase; cl11426
378806011371	Predicted membrane protein [Function unknown]; Region: COG1289
378806011372	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
378806011373	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806011374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806011375	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
378806011376	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
378806011377	substrate binding pocket [chemical binding]; other site
378806011378	chain length determination region; other site
378806011379	substrate-Mg2+ binding site; other site
378806011380	catalytic residues [active]
378806011381	aspartate-rich region 1; other site
378806011382	active site lid residues [active]
378806011383	aspartate-rich region 2; other site
378806011384	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806011385	dimerization interface [polypeptide binding]; other site
378806011386	putative Zn2+ binding site [ion binding]; other site
378806011387	putative DNA binding site [nucleotide binding]; other site
378806011388	dimerization interface [polypeptide binding]; other site
378806011389	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
378806011390	putative catalytic residue [active]
378806011391	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
378806011392	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
378806011393	active site
378806011394	metal binding site [ion binding]; metal-binding site
378806011395	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
378806011396	glycogen branching enzyme; Provisional; Region: PRK05402
378806011397	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
378806011398	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
378806011399	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
378806011400	active site
378806011401	catalytic site [active]
378806011402	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
378806011403	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
378806011404	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
378806011405	trehalose synthase; Region: treS_nterm; TIGR02456
378806011406	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
378806011407	active site
378806011408	catalytic site [active]
378806011409	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
378806011410	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
378806011411	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
378806011412	active site
378806011413	homodimer interface [polypeptide binding]; other site
378806011414	catalytic site [active]
378806011415	acceptor binding site [chemical binding]; other site
378806011416	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
378806011417	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806011418	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806011419	DNA binding residues [nucleotide binding]
378806011420	putative aminotransferase; Provisional; Region: PRK12414
378806011421	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806011422	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806011423	homodimer interface [polypeptide binding]; other site
378806011424	catalytic residue [active]
378806011425	PBP superfamily domain; Region: PBP_like_2; cl17296
378806011426	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
378806011427	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
378806011428	active site
378806011429	PHP-associated; Region: PHP_C; pfam13263
378806011430	methionine sulfoxide reductase B; Provisional; Region: PRK00222
378806011431	SelR domain; Region: SelR; pfam01641
378806011432	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
378806011433	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
378806011434	tetramer interface [polypeptide binding]; other site
378806011435	heme binding pocket [chemical binding]; other site
378806011436	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
378806011437	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
378806011438	domain interactions; other site
378806011439	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
378806011440	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
378806011441	metal binding site 2 [ion binding]; metal-binding site
378806011442	putative DNA binding helix; other site
378806011443	metal binding site 1 [ion binding]; metal-binding site
378806011444	dimer interface [polypeptide binding]; other site
378806011445	structural Zn2+ binding site [ion binding]; other site
378806011446	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
378806011447	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806011448	catalytic residues [active]
378806011449	Septum formation initiator; Region: DivIC; pfam04977
378806011450	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806011451	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806011452	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806011453	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806011454	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806011455	metal binding site [ion binding]; metal-binding site
378806011456	active site
378806011457	I-site; other site
378806011458	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
378806011459	Transcriptional regulators [Transcription]; Region: MarR; COG1846
378806011460	MarR family; Region: MarR_2; pfam12802
378806011461	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
378806011462	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806011463	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806011464	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806011465	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
378806011466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806011467	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806011468	acyl-CoA synthetase; Validated; Region: PRK05850
378806011469	acyl-activating enzyme (AAE) consensus motif; other site
378806011470	active site
378806011471	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806011472	Condensation domain; Region: Condensation; pfam00668
378806011473	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806011474	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806011475	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806011476	acyl-activating enzyme (AAE) consensus motif; other site
378806011477	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
378806011478	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
378806011479	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
378806011480	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806011481	AMP binding site [chemical binding]; other site
378806011482	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011483	Penicillin amidase; Region: Penicil_amidase; pfam01804
378806011484	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
378806011485	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
378806011486	active site
378806011487	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
378806011488	Cupin-like domain; Region: Cupin_8; pfam13621
378806011489	H+ Antiporter protein; Region: 2A0121; TIGR00900
378806011490	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
378806011491	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
378806011492	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806011493	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806011494	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806011495	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806011496	active site
378806011497	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806011498	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806011499	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011500	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806011501	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806011502	active site
378806011503	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806011504	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806011505	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
378806011506	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806011507	putative NADP binding site [chemical binding]; other site
378806011508	active site
378806011509	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806011510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806011511	S-adenosylmethionine binding site [chemical binding]; other site
378806011512	5' nucleotidase family; Region: 5_nucleotid; pfam05761
378806011513	Protein kinase domain; Region: Pkinase; pfam00069
378806011514	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806011515	active site
378806011516	ATP binding site [chemical binding]; other site
378806011517	substrate binding site [chemical binding]; other site
378806011518	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806011519	substrate binding site [chemical binding]; other site
378806011520	activation loop (A-loop); other site
378806011521	activation loop (A-loop); other site
378806011522	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806011523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806011524	active site
378806011525	phosphorylation site [posttranslational modification]
378806011526	intermolecular recognition site; other site
378806011527	dimerization interface [polypeptide binding]; other site
378806011528	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806011529	DNA binding residues [nucleotide binding]
378806011530	dimerization interface [polypeptide binding]; other site
378806011531	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806011532	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806011533	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806011534	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806011535	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806011536	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806011537	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
378806011538	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806011539	active site
378806011540	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
378806011541	Permease; Region: Permease; pfam02405
378806011542	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
378806011543	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
378806011544	Walker A/P-loop; other site
378806011545	ATP binding site [chemical binding]; other site
378806011546	Q-loop/lid; other site
378806011547	ABC transporter signature motif; other site
378806011548	Walker B; other site
378806011549	D-loop; other site
378806011550	H-loop/switch region; other site
378806011551	mce related protein; Region: MCE; pfam02470
378806011552	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
378806011553	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
378806011554	substrate binding site [chemical binding]; other site
378806011555	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
378806011556	ATP binding site [chemical binding]; other site
378806011557	PilZ domain; Region: PilZ; cl01260
378806011558	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806011559	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
378806011560	active site
378806011561	metal binding site [ion binding]; metal-binding site
378806011562	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
378806011563	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
378806011564	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
378806011565	dimer interface [polypeptide binding]; other site
378806011566	motif 1; other site
378806011567	active site
378806011568	motif 2; other site
378806011569	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
378806011570	anticodon binding site; other site
378806011571	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806011572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806011573	ATP binding site [chemical binding]; other site
378806011574	Mg2+ binding site [ion binding]; other site
378806011575	G-X-G motif; other site
378806011576	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806011577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806011578	active site
378806011579	phosphorylation site [posttranslational modification]
378806011580	intermolecular recognition site; other site
378806011581	dimerization interface [polypeptide binding]; other site
378806011582	metabolite-proton symporter; Region: 2A0106; TIGR00883
378806011583	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806011584	putative substrate translocation pore; other site
378806011585	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806011586	putative transporter; Provisional; Region: PRK10504
378806011587	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
378806011588	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
378806011589	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
378806011590	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806011591	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806011592	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806011593	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
378806011594	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
378806011595	Response regulator receiver domain; Region: Response_reg; pfam00072
378806011596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806011597	active site
378806011598	phosphorylation site [posttranslational modification]
378806011599	intermolecular recognition site; other site
378806011600	dimerization interface [polypeptide binding]; other site
378806011601	Response regulator receiver domain; Region: Response_reg; pfam00072
378806011602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806011603	active site
378806011604	phosphorylation site [posttranslational modification]
378806011605	intermolecular recognition site; other site
378806011606	dimerization interface [polypeptide binding]; other site
378806011607	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806011608	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806011609	metal binding site [ion binding]; metal-binding site
378806011610	active site
378806011611	I-site; other site
378806011612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806011613	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806011614	TPR motif; other site
378806011615	binding surface
378806011616	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806011617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806011618	active site
378806011619	phosphorylation site [posttranslational modification]
378806011620	intermolecular recognition site; other site
378806011621	dimerization interface [polypeptide binding]; other site
378806011622	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
378806011623	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
378806011624	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
378806011625	putative active site; other site
378806011626	catalytic residue [active]
378806011627	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
378806011628	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
378806011629	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806011630	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806011631	NAD(P) binding site [chemical binding]; other site
378806011632	active site
378806011633	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
378806011634	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
378806011635	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806011636	catalytic residue [active]
378806011637	aminotransferase; Validated; Region: PRK07777
378806011638	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806011639	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806011640	homodimer interface [polypeptide binding]; other site
378806011641	catalytic residue [active]
378806011642	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806011643	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806011644	S-adenosylmethionine binding site [chemical binding]; other site
378806011645	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
378806011646	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
378806011647	active site
378806011648	catalytic residues [active]
378806011649	metal binding site [ion binding]; metal-binding site
378806011650	NADH(P)-binding; Region: NAD_binding_10; pfam13460
378806011651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806011652	NAD(P) binding site [chemical binding]; other site
378806011653	active site
378806011654	potential frameshift: common BLAST hit: gi|220910734|ref|YP_002486044.1| transposase IS66
378806011655	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806011656	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
378806011657	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806011658	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806011659	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806011660	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806011661	active site
378806011662	ATP binding site [chemical binding]; other site
378806011663	substrate binding site [chemical binding]; other site
378806011664	activation loop (A-loop); other site
378806011665	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
378806011666	conserved hypothetical protein; Region: TIGR02231
378806011667	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
378806011668	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
378806011669	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
378806011670	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
378806011671	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
378806011672	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806011673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806011674	S-adenosylmethionine binding site [chemical binding]; other site
378806011675	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806011676	putative catalytic site [active]
378806011677	putative metal binding site [ion binding]; other site
378806011678	putative phosphate binding site [ion binding]; other site
378806011679	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
378806011680	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
378806011681	tRNA; other site
378806011682	putative tRNA binding site [nucleotide binding]; other site
378806011683	putative NADP binding site [chemical binding]; other site
378806011684	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
378806011685	DoxX; Region: DoxX; pfam07681
378806011686	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
378806011687	Response regulator receiver domain; Region: Response_reg; pfam00072
378806011688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806011689	active site
378806011690	phosphorylation site [posttranslational modification]
378806011691	intermolecular recognition site; other site
378806011692	dimerization interface [polypeptide binding]; other site
378806011693	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806011694	active site
378806011695	ATP binding site [chemical binding]; other site
378806011696	substrate binding site [chemical binding]; other site
378806011697	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
378806011698	activation loop (A-loop); other site
378806011699	cyclase homology domain; Region: CHD; cd07302
378806011700	nucleotidyl binding site; other site
378806011701	metal binding site [ion binding]; metal-binding site
378806011702	dimer interface [polypeptide binding]; other site
378806011703	AAA ATPase domain; Region: AAA_16; pfam13191
378806011704	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806011705	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806011706	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
378806011707	active site
378806011708	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
378806011709	dimer interface [polypeptide binding]; other site
378806011710	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
378806011711	Ligand Binding Site [chemical binding]; other site
378806011712	Molecular Tunnel; other site
378806011713	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806011714	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806011715	hypothetical protein; Provisional; Region: PRK05409
378806011716	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
378806011717	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806011718	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
378806011719	active site
378806011720	TDP-binding site; other site
378806011721	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
378806011722	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
378806011723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
378806011724	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806011725	putative sugar binding sites [chemical binding]; other site
378806011726	Q-X-W motif; other site
378806011727	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806011728	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806011729	putative sugar binding sites [chemical binding]; other site
378806011730	Q-X-W motif; other site
378806011731	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806011732	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
378806011733	tellurium resistance terB-like protein; Region: terB_like; cd07177
378806011734	metal binding site [ion binding]; metal-binding site
378806011735	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806011736	enoyl-CoA hydratase; Provisional; Region: PRK07657
378806011737	substrate binding site [chemical binding]; other site
378806011738	oxyanion hole (OAH) forming residues; other site
378806011739	trimer interface [polypeptide binding]; other site
378806011740	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
378806011741	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
378806011742	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
378806011743	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
378806011744	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
378806011745	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
378806011746	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
378806011747	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
378806011748	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
378806011749	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
378806011750	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
378806011751	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
378806011752	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
378806011753	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
378806011754	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
378806011755	N-terminal plug; other site
378806011756	ligand-binding site [chemical binding]; other site
378806011757	GAF domain; Region: GAF_3; pfam13492
378806011758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806011759	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806011760	dimer interface [polypeptide binding]; other site
378806011761	phosphorylation site [posttranslational modification]
378806011762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806011763	ATP binding site [chemical binding]; other site
378806011764	Mg2+ binding site [ion binding]; other site
378806011765	G-X-G motif; other site
378806011766	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806011767	Walker B motif; other site
378806011768	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
378806011769	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806011770	Walker A motif; other site
378806011771	ATP binding site [chemical binding]; other site
378806011772	Walker B motif; other site
378806011773	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806011774	Walker A motif; other site
378806011775	Response regulator receiver domain; Region: Response_reg; pfam00072
378806011776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806011777	active site
378806011778	phosphorylation site [posttranslational modification]
378806011779	intermolecular recognition site; other site
378806011780	dimerization interface [polypeptide binding]; other site
378806011781	Secretory lipase; Region: LIP; pfam03583
378806011782	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
378806011783	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
378806011784	putative dimer interface [polypeptide binding]; other site
378806011785	Epoxide hydrolase N terminus; Region: EHN; pfam06441
378806011786	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806011787	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
378806011788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806011789	putative substrate translocation pore; other site
378806011790	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
378806011791	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
378806011792	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
378806011793	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806011794	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806011795	active site
378806011796	ribonuclease III; Reviewed; Region: rnc; PRK00102
378806011797	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
378806011798	dimerization interface [polypeptide binding]; other site
378806011799	active site
378806011800	metal binding site [ion binding]; metal-binding site
378806011801	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
378806011802	dsRNA binding site [nucleotide binding]; other site
378806011803	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
378806011804	active site
378806011805	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
378806011806	active site
378806011807	GTPase Era; Reviewed; Region: era; PRK00089
378806011808	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
378806011809	G1 box; other site
378806011810	GTP/Mg2+ binding site [chemical binding]; other site
378806011811	Switch I region; other site
378806011812	G2 box; other site
378806011813	Switch II region; other site
378806011814	G3 box; other site
378806011815	G4 box; other site
378806011816	G5 box; other site
378806011817	KH domain; Region: KH_2; pfam07650
378806011818	GTP-binding protein Der; Reviewed; Region: PRK00093
378806011819	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
378806011820	G1 box; other site
378806011821	GTP/Mg2+ binding site [chemical binding]; other site
378806011822	Switch I region; other site
378806011823	G2 box; other site
378806011824	Switch II region; other site
378806011825	G3 box; other site
378806011826	G4 box; other site
378806011827	G5 box; other site
378806011828	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
378806011829	G1 box; other site
378806011830	GTP/Mg2+ binding site [chemical binding]; other site
378806011831	Switch I region; other site
378806011832	G2 box; other site
378806011833	G3 box; other site
378806011834	Switch II region; other site
378806011835	G4 box; other site
378806011836	G5 box; other site
378806011837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806011838	binding surface
378806011839	TPR motif; other site
378806011840	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
378806011841	PQQ-like domain; Region: PQQ_2; pfam13360
378806011842	Trp docking motif [polypeptide binding]; other site
378806011843	active site
378806011844	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
378806011845	active site
378806011846	8-oxo-dGMP binding site [chemical binding]; other site
378806011847	nudix motif; other site
378806011848	metal binding site [ion binding]; metal-binding site
378806011849	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
378806011850	RNase_H superfamily; Region: RNase_H_2; pfam13482
378806011851	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
378806011852	Peptidase S46; Region: Peptidase_S46; pfam10459
378806011853	Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949
378806011854	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
378806011855	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
378806011856	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806011857	substrate binding site [chemical binding]; other site
378806011858	oxyanion hole (OAH) forming residues; other site
378806011859	trimer interface [polypeptide binding]; other site
378806011860	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
378806011861	GMP synthase; Reviewed; Region: guaA; PRK00074
378806011862	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
378806011863	AMP/PPi binding site [chemical binding]; other site
378806011864	candidate oxyanion hole; other site
378806011865	catalytic triad [active]
378806011866	potential glutamine specificity residues [chemical binding]; other site
378806011867	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
378806011868	ATP Binding subdomain [chemical binding]; other site
378806011869	Ligand Binding sites [chemical binding]; other site
378806011870	Dimerization subdomain; other site
378806011871	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
378806011872	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
378806011873	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
378806011874	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
378806011875	active site
378806011876	PilZ domain; Region: PilZ; cl01260
378806011877	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806011878	nucleotide binding site [chemical binding]; other site
378806011879	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
378806011880	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
378806011881	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806011882	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806011883	ligand binding site [chemical binding]; other site
378806011884	flexible hinge region; other site
378806011885	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
378806011886	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
378806011887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806011888	FeS/SAM binding site; other site
378806011889	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
378806011890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
378806011891	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
378806011892	TRAM domain; Region: TRAM; cl01282
378806011893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806011894	S-adenosylmethionine binding site [chemical binding]; other site
378806011895	Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266
378806011896	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
378806011897	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
378806011898	putative acyltransferase; Provisional; Region: PRK05790
378806011899	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
378806011900	dimer interface [polypeptide binding]; other site
378806011901	active site
378806011902	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
378806011903	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
378806011904	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
378806011905	RNA binding site [nucleotide binding]; other site
378806011906	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
378806011907	RNA binding site [nucleotide binding]; other site
378806011908	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
378806011909	RNA binding site [nucleotide binding]; other site
378806011910	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
378806011911	RNA binding site [nucleotide binding]; other site
378806011912	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
378806011913	RNA binding site [nucleotide binding]; other site
378806011914	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
378806011915	RNA binding site [nucleotide binding]; other site
378806011916	domain interface; other site
378806011917	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806011918	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
378806011919	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
378806011920	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
378806011921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806011922	dimer interface [polypeptide binding]; other site
378806011923	conserved gate region; other site
378806011924	putative PBP binding loops; other site
378806011925	ABC-ATPase subunit interface; other site
378806011926	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
378806011927	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806011928	dimer interface [polypeptide binding]; other site
378806011929	conserved gate region; other site
378806011930	putative PBP binding loops; other site
378806011931	ABC-ATPase subunit interface; other site
378806011932	Protein kinase domain; Region: Pkinase; pfam00069
378806011933	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806011934	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806011935	active site
378806011936	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806011937	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
378806011938	FAD binding site [chemical binding]; other site
378806011939	homotetramer interface [polypeptide binding]; other site
378806011940	substrate binding pocket [chemical binding]; other site
378806011941	catalytic base [active]
378806011942	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
378806011943	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806011944	substrate binding site [chemical binding]; other site
378806011945	oxyanion hole (OAH) forming residues; other site
378806011946	trimer interface [polypeptide binding]; other site
378806011947	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
378806011948	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
378806011949	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
378806011950	Domain of unknown function DUF59; Region: DUF59; pfam01883
378806011951	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
378806011952	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
378806011953	Walker A motif; other site
378806011954	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
378806011955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806011956	S-adenosylmethionine binding site [chemical binding]; other site
378806011957	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
378806011958	chorismate binding enzyme; Region: Chorismate_bind; cl10555
378806011959	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
378806011960	oligomer interface [polypeptide binding]; other site
378806011961	tandem repeat interface [polypeptide binding]; other site
378806011962	active site residues [active]
378806011963	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
378806011964	tandem repeat interface [polypeptide binding]; other site
378806011965	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
378806011966	oligomer interface [polypeptide binding]; other site
378806011967	active site residues [active]
378806011968	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
378806011969	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
378806011970	putative active site [active]
378806011971	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
378806011972	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
378806011973	transmembrane helices; other site
378806011974	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
378806011975	putative hydrophobic ligand binding site [chemical binding]; other site
378806011976	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806011977	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806011978	TPR repeat; Region: TPR_11; pfam13414
378806011979	binding surface
378806011980	TPR motif; other site
378806011981	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806011982	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806011983	ligand binding site [chemical binding]; other site
378806011984	flexible hinge region; other site
378806011985	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806011986	ligand binding site [chemical binding]; other site
378806011987	flexible hinge region; other site
378806011988	HEAT repeats; Region: HEAT_2; pfam13646
378806011989	HEAT repeats; Region: HEAT_2; pfam13646
378806011990	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
378806011991	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806011992	RNA binding surface [nucleotide binding]; other site
378806011993	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
378806011994	active site
378806011995	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
378806011996	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
378806011997	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
378806011998	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
378806011999	active site
378806012000	HIGH motif; other site
378806012001	dimer interface [polypeptide binding]; other site
378806012002	KMSKS motif; other site
378806012003	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
378806012004	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806012005	active site
378806012006	metal binding site [ion binding]; metal-binding site
378806012007	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
378806012008	active site
378806012009	catalytic residues [active]
378806012010	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
378806012011	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
378806012012	metal binding site [ion binding]; metal-binding site
378806012013	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806012014	sugar binding site [chemical binding]; other site
378806012015	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806012016	sugar binding site [chemical binding]; other site
378806012017	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
378806012018	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
378806012019	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
378806012020	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806012021	Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789
378806012022	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
378806012023	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
378806012024	active site
378806012025	Int/Topo IB signature motif; other site
378806012026	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
378806012027	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
378806012028	Small hydrophilic plant seed protein; Region: LEA_5; pfam00477
378806012029	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
378806012030	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
378806012031	active site
378806012032	metal binding site [ion binding]; metal-binding site
378806012033	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806012034	active site
378806012035	ATP binding site [chemical binding]; other site
378806012036	substrate binding site [chemical binding]; other site
378806012037	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
378806012038	activation loop (A-loop); other site
378806012039	cyclase homology domain; Region: CHD; cd07302
378806012040	dimer interface [polypeptide binding]; other site
378806012041	nucleotidyl binding site; other site
378806012042	metal binding site [ion binding]; metal-binding site
378806012043	AAA ATPase domain; Region: AAA_16; pfam13191
378806012044	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
378806012045	MutS domain I; Region: MutS_I; pfam01624
378806012046	MutS domain II; Region: MutS_II; pfam05188
378806012047	MutS domain III; Region: MutS_III; pfam05192
378806012048	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
378806012049	Walker A/P-loop; other site
378806012050	ATP binding site [chemical binding]; other site
378806012051	Q-loop/lid; other site
378806012052	ABC transporter signature motif; other site
378806012053	Walker B; other site
378806012054	D-loop; other site
378806012055	H-loop/switch region; other site
378806012056	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
378806012057	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806012058	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806012059	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
378806012060	ABC1 family; Region: ABC1; pfam03109
378806012061	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
378806012062	active site
378806012063	ATP binding site [chemical binding]; other site
378806012064	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
378806012065	putative C-terminal domain interface [polypeptide binding]; other site
378806012066	putative GSH binding site (G-site) [chemical binding]; other site
378806012067	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806012068	putative dimer interface [polypeptide binding]; other site
378806012069	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
378806012070	dimer interface [polypeptide binding]; other site
378806012071	N-terminal domain interface [polypeptide binding]; other site
378806012072	putative substrate binding pocket (H-site) [chemical binding]; other site
378806012073	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806012074	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806012075	active site
378806012076	ATP binding site [chemical binding]; other site
378806012077	substrate binding site [chemical binding]; other site
378806012078	activation loop (A-loop); other site
378806012079	MutS domain III; Region: MutS_III; pfam05192
378806012080	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806012081	Walker A/P-loop; other site
378806012082	ATP binding site [chemical binding]; other site
378806012083	Q-loop/lid; other site
378806012084	ABC transporter signature motif; other site
378806012085	Walker B; other site
378806012086	D-loop; other site
378806012087	H-loop/switch region; other site
378806012088	GAF domain; Region: GAF; pfam01590
378806012089	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806012090	PAS fold; Region: PAS_4; pfam08448
378806012091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806012092	putative active site [active]
378806012093	heme pocket [chemical binding]; other site
378806012094	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806012095	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806012096	putative active site [active]
378806012097	heme pocket [chemical binding]; other site
378806012098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
378806012099	dimer interface [polypeptide binding]; other site
378806012100	phosphorylation site [posttranslational modification]
378806012101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012102	ATP binding site [chemical binding]; other site
378806012103	Mg2+ binding site [ion binding]; other site
378806012104	G-X-G motif; other site
378806012105	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
378806012106	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
378806012107	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
378806012108	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
378806012109	NYN domain; Region: NYN; pfam01936
378806012110	putative metal binding site [ion binding]; other site
378806012111	Uncharacterized conserved protein [Function unknown]; Region: COG1432
378806012112	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
378806012113	PilZ domain; Region: PilZ; pfam07238
378806012114	PilZ domain; Region: PilZ; cl01260
378806012115	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
378806012116	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806012117	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806012118	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806012119	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
378806012120	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806012121	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
378806012122	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
378806012123	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806012124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806012125	Walker A motif; other site
378806012126	ATP binding site [chemical binding]; other site
378806012127	Walker B motif; other site
378806012128	arginine finger; other site
378806012129	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806012130	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806012131	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
378806012132	TM-ABC transporter signature motif; other site
378806012133	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806012134	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
378806012135	TM-ABC transporter signature motif; other site
378806012136	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
378806012137	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
378806012138	Walker A/P-loop; other site
378806012139	ATP binding site [chemical binding]; other site
378806012140	Q-loop/lid; other site
378806012141	ABC transporter signature motif; other site
378806012142	Walker B; other site
378806012143	D-loop; other site
378806012144	H-loop/switch region; other site
378806012145	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
378806012146	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
378806012147	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
378806012148	putative ligand binding site [chemical binding]; other site
378806012149	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
378806012150	putative substrate binding site [chemical binding]; other site
378806012151	active site
378806012152	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
378806012153	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
378806012154	putative substrate binding site [chemical binding]; other site
378806012155	active site
378806012156	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
378806012157	mevalonate kinase; Region: mevalon_kin; TIGR00549
378806012158	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
378806012159	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
378806012160	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
378806012161	active site
378806012162	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
378806012163	active site
378806012164	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806012165	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806012166	active site
378806012167	ATP binding site [chemical binding]; other site
378806012168	substrate binding site [chemical binding]; other site
378806012169	activation loop (A-loop); other site
378806012170	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806012171	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806012172	phosphopeptide binding site; other site
378806012173	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806012174	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806012175	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806012176	cyclase homology domain; Region: CHD; cd07302
378806012177	nucleotidyl binding site; other site
378806012178	metal binding site [ion binding]; metal-binding site
378806012179	dimer interface [polypeptide binding]; other site
378806012180	Uncharacterized conserved protein [Function unknown]; Region: COG0585
378806012181	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
378806012182	active site
378806012183	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806012184	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806012185	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806012186	DNA binding residues [nucleotide binding]
378806012187	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
378806012188	Protein of unknown function (DUF342); Region: DUF342; pfam03961
378806012189	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
378806012190	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
378806012191	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
378806012192	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
378806012193	KR domain; Region: KR; pfam08659
378806012194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806012195	NAD(P) binding site [chemical binding]; other site
378806012196	active site
378806012197	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
378806012198	Ligand Binding Site [chemical binding]; other site
378806012199	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806012200	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
378806012201	putative acyl-acceptor binding pocket; other site
378806012202	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806012203	TAP-like protein; Region: Abhydrolase_4; pfam08386
378806012204	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806012205	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806012206	active site
378806012207	catalytic tetrad [active]
378806012208	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
378806012209	GAF domain; Region: GAF_2; pfam13185
378806012210	GAF domain; Region: GAF; pfam01590
378806012211	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
378806012212	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806012213	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806012214	putative active site [active]
378806012215	heme pocket [chemical binding]; other site
378806012216	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806012217	dimer interface [polypeptide binding]; other site
378806012218	phosphorylation site [posttranslational modification]
378806012219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012220	ATP binding site [chemical binding]; other site
378806012221	Mg2+ binding site [ion binding]; other site
378806012222	G-X-G motif; other site
378806012223	WbqC-like protein family; Region: WbqC; pfam08889
378806012224	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
378806012225	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806012226	active site
378806012227	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
378806012228	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
378806012229	putative active site [active]
378806012230	catalytic triad [active]
378806012231	putative dimer interface [polypeptide binding]; other site
378806012232	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
378806012233	active site
378806012234	oxyanion hole [active]
378806012235	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
378806012236	active site
378806012237	oxyanion hole [active]
378806012238	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
378806012239	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
378806012240	putative active site [active]
378806012241	putative PHP Thumb interface [polypeptide binding]; other site
378806012242	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
378806012243	generic binding surface I; other site
378806012244	generic binding surface II; other site
378806012245	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
378806012246	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
378806012247	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
378806012248	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
378806012249	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806012250	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806012251	DNA Polymerase Y-family; Region: PolY_like; cd03468
378806012252	active site
378806012253	DNA binding site [nucleotide binding]
378806012254	recA bacterial DNA recombination protein; Region: RecA; cl17211
378806012255	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
378806012256	metal ion-dependent adhesion site (MIDAS); other site
378806012257	Found in ATP-dependent protease La (LON); Region: LON; smart00464
378806012258	ATP-dependent protease La; Region: lon; TIGR00763
378806012259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806012260	Walker A motif; other site
378806012261	ATP binding site [chemical binding]; other site
378806012262	Walker B motif; other site
378806012263	arginine finger; other site
378806012264	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
378806012265	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806012266	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806012267	active site
378806012268	ATP binding site [chemical binding]; other site
378806012269	substrate binding site [chemical binding]; other site
378806012270	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806012271	substrate binding site [chemical binding]; other site
378806012272	activation loop (A-loop); other site
378806012273	activation loop (A-loop); other site
378806012274	Predicted ATPase [General function prediction only]; Region: COG3899
378806012275	AAA ATPase domain; Region: AAA_16; pfam13191
378806012276	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806012277	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806012278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806012279	dimer interface [polypeptide binding]; other site
378806012280	phosphorylation site [posttranslational modification]
378806012281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012282	ATP binding site [chemical binding]; other site
378806012283	Mg2+ binding site [ion binding]; other site
378806012284	G-X-G motif; other site
378806012285	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
378806012286	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
378806012287	heme binding pocket [chemical binding]; other site
378806012288	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806012289	active site
378806012290	ATP binding site [chemical binding]; other site
378806012291	substrate binding site [chemical binding]; other site
378806012292	activation loop (A-loop); other site
378806012293	Predicted membrane protein [Function unknown]; Region: COG4270
378806012294	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
378806012295	heme binding pocket [chemical binding]; other site
378806012296	heme ligand [chemical binding]; other site
378806012297	YceG-like family; Region: YceG; pfam02618
378806012298	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
378806012299	dimerization interface [polypeptide binding]; other site
378806012300	PAS fold; Region: PAS_4; pfam08448
378806012301	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806012302	putative active site [active]
378806012303	heme pocket [chemical binding]; other site
378806012304	PAS domain; Region: PAS_9; pfam13426
378806012305	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806012306	Heme NO binding associated; Region: HNOBA; pfam07701
378806012307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806012308	dimer interface [polypeptide binding]; other site
378806012309	phosphorylation site [posttranslational modification]
378806012310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012311	ATP binding site [chemical binding]; other site
378806012312	Mg2+ binding site [ion binding]; other site
378806012313	G-X-G motif; other site
378806012314	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806012315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012316	active site
378806012317	phosphorylation site [posttranslational modification]
378806012318	intermolecular recognition site; other site
378806012319	dimerization interface [polypeptide binding]; other site
378806012320	Response regulator receiver domain; Region: Response_reg; pfam00072
378806012321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012322	active site
378806012323	phosphorylation site [posttranslational modification]
378806012324	intermolecular recognition site; other site
378806012325	dimerization interface [polypeptide binding]; other site
378806012326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806012327	S-adenosylmethionine binding site [chemical binding]; other site
378806012328	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
378806012329	serpin-like protein; Provisional; Region: PHA02660
378806012330	reactive center loop; other site
378806012331	HYR domain; Region: HYR; pfam02494
378806012332	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806012333	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806012334	phosphopeptide binding site; other site
378806012335	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
378806012336	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806012337	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806012338	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806012339	active site
378806012340	ATP binding site [chemical binding]; other site
378806012341	substrate binding site [chemical binding]; other site
378806012342	activation loop (A-loop); other site
378806012343	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806012344	Response regulator receiver domain; Region: Response_reg; pfam00072
378806012345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012346	active site
378806012347	phosphorylation site [posttranslational modification]
378806012348	intermolecular recognition site; other site
378806012349	dimerization interface [polypeptide binding]; other site
378806012350	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
378806012351	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806012352	non-specific DNA binding site [nucleotide binding]; other site
378806012353	salt bridge; other site
378806012354	sequence-specific DNA binding site [nucleotide binding]; other site
378806012355	Cupin domain; Region: Cupin_2; pfam07883
378806012356	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806012357	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806012358	active site
378806012359	ATP binding site [chemical binding]; other site
378806012360	substrate binding site [chemical binding]; other site
378806012361	activation loop (A-loop); other site
378806012362	FHA domain; Region: FHA; pfam00498
378806012363	phosphopeptide binding site; other site
378806012364	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
378806012365	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806012366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806012367	Walker A motif; other site
378806012368	ATP binding site [chemical binding]; other site
378806012369	Walker B motif; other site
378806012370	arginine finger; other site
378806012371	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806012372	Cys-rich repeat, Myxococcales-type; Region: Myxo_Cys_RPT; TIGR04201
378806012373	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806012374	binding surface
378806012375	TPR motif; other site
378806012376	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
378806012377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012378	ATP binding site [chemical binding]; other site
378806012379	Mg2+ binding site [ion binding]; other site
378806012380	G-X-G motif; other site
378806012381	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
378806012382	ATP binding site [chemical binding]; other site
378806012383	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
378806012384	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806012385	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
378806012386	putative NAD(P) binding site [chemical binding]; other site
378806012387	active site
378806012388	putative substrate binding site [chemical binding]; other site
378806012389	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
378806012390	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806012391	putative acyl-acceptor binding pocket; other site
378806012392	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806012393	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806012394	phosphopeptide binding site; other site
378806012395	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806012396	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806012397	metal binding site [ion binding]; metal-binding site
378806012398	active site
378806012399	I-site; other site
378806012400	Protein of unknown function (DUF721); Region: DUF721; pfam05258
378806012401	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
378806012402	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
378806012403	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
378806012404	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
378806012405	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806012406	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806012407	catalytic residue [active]
378806012408	cytidylate kinase; Provisional; Region: cmk; PRK00023
378806012409	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
378806012410	CMP-binding site; other site
378806012411	The sites determining sugar specificity; other site
378806012412	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
378806012413	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
378806012414	TPR repeat; Region: TPR_11; pfam13414
378806012415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806012416	binding surface
378806012417	TPR motif; other site
378806012418	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
378806012419	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
378806012420	DTAP/Switch II; other site
378806012421	Switch I; other site
378806012422	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
378806012423	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
378806012424	P loop; other site
378806012425	Nucleotide binding site [chemical binding]; other site
378806012426	DTAP/Switch II; other site
378806012427	Switch I; other site
378806012428	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806012429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012430	active site
378806012431	phosphorylation site [posttranslational modification]
378806012432	intermolecular recognition site; other site
378806012433	dimerization interface [polypeptide binding]; other site
378806012434	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806012435	Walker A motif; other site
378806012436	ATP binding site [chemical binding]; other site
378806012437	Walker B motif; other site
378806012438	arginine finger; other site
378806012439	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806012440	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806012441	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806012442	phosphorylation site [posttranslational modification]
378806012443	dimer interface [polypeptide binding]; other site
378806012444	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
378806012445	catalytic motif [active]
378806012446	Zn binding site [ion binding]; other site
378806012447	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806012448	PrkA AAA domain; Region: AAA_PrkA; smart00763
378806012449	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
378806012450	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806012451	rod-share determining protein MreBH; Provisional; Region: PRK13929
378806012452	nucleotide binding site [chemical binding]; other site
378806012453	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
378806012454	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
378806012455	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
378806012456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806012457	Walker A motif; other site
378806012458	ATP binding site [chemical binding]; other site
378806012459	Walker B motif; other site
378806012460	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
378806012461	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
378806012462	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
378806012463	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
378806012464	active site
378806012465	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
378806012466	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
378806012467	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
378806012468	Ligand Binding Site [chemical binding]; other site
378806012469	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
378806012470	ligand-binding site [chemical binding]; other site
378806012471	Shikimate kinase; Region: SKI; pfam01202
378806012472	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
378806012473	MPN+ (JAMM) motif; other site
378806012474	Zinc-binding site [ion binding]; other site
378806012475	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
378806012476	MoaE interaction surface [polypeptide binding]; other site
378806012477	MoeB interaction surface [polypeptide binding]; other site
378806012478	thiocarboxylated glycine; other site
378806012479	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
378806012480	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
378806012481	ATP binding site [chemical binding]; other site
378806012482	substrate interface [chemical binding]; other site
378806012483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
378806012484	Histidine kinase; Region: HisKA_3; pfam07730
378806012485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012486	ATP binding site [chemical binding]; other site
378806012487	Mg2+ binding site [ion binding]; other site
378806012488	G-X-G motif; other site
378806012489	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806012490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012491	active site
378806012492	phosphorylation site [posttranslational modification]
378806012493	intermolecular recognition site; other site
378806012494	dimerization interface [polypeptide binding]; other site
378806012495	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806012496	DNA binding residues [nucleotide binding]
378806012497	dimerization interface [polypeptide binding]; other site
378806012498	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806012499	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806012500	DNA-binding site [nucleotide binding]; DNA binding site
378806012501	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806012502	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
378806012503	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
378806012504	active site
378806012505	phosphorylation site [posttranslational modification]
378806012506	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
378806012507	dimerization domain swap beta strand [polypeptide binding]; other site
378806012508	regulatory protein interface [polypeptide binding]; other site
378806012509	active site
378806012510	regulatory phosphorylation site [posttranslational modification]; other site
378806012511	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
378806012512	phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417
378806012513	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
378806012514	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
378806012515	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
378806012516	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
378806012517	putative substrate binding site [chemical binding]; other site
378806012518	putative ATP binding site [chemical binding]; other site
378806012519	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
378806012520	active site
378806012521	P-loop; other site
378806012522	phosphorylation site [posttranslational modification]
378806012523	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
378806012524	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
378806012525	active site
378806012526	P-loop; other site
378806012527	phosphorylation site [posttranslational modification]
378806012528	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
378806012529	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
378806012530	amidase catalytic site [active]
378806012531	Zn binding residues [ion binding]; other site
378806012532	substrate binding site [chemical binding]; other site
378806012533	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
378806012534	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
378806012535	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
378806012536	active site
378806012537	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
378806012538	catalytic triad [active]
378806012539	dimer interface [polypeptide binding]; other site
378806012540	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
378806012541	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
378806012542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806012543	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806012544	dimerization interface [polypeptide binding]; other site
378806012545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806012546	dimer interface [polypeptide binding]; other site
378806012547	phosphorylation site [posttranslational modification]
378806012548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012549	ATP binding site [chemical binding]; other site
378806012550	Mg2+ binding site [ion binding]; other site
378806012551	G-X-G motif; other site
378806012552	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806012553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012554	active site
378806012555	phosphorylation site [posttranslational modification]
378806012556	intermolecular recognition site; other site
378806012557	dimerization interface [polypeptide binding]; other site
378806012558	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806012559	Walker A motif; other site
378806012560	ATP binding site [chemical binding]; other site
378806012561	Walker B motif; other site
378806012562	arginine finger; other site
378806012563	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806012564	Response regulator receiver domain; Region: Response_reg; pfam00072
378806012565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012566	active site
378806012567	phosphorylation site [posttranslational modification]
378806012568	intermolecular recognition site; other site
378806012569	dimerization interface [polypeptide binding]; other site
378806012570	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
378806012571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
378806012572	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
378806012573	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
378806012574	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
378806012575	Sulfate transporter family; Region: Sulfate_transp; pfam00916
378806012576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806012577	binding surface
378806012578	TPR motif; other site
378806012579	TPR repeat; Region: TPR_11; pfam13414
378806012580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012581	active site
378806012582	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806012583	phosphorylation site [posttranslational modification]
378806012584	intermolecular recognition site; other site
378806012585	dimerization interface [polypeptide binding]; other site
378806012586	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806012587	dimer interface [polypeptide binding]; other site
378806012588	phosphorylation site [posttranslational modification]
378806012589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012590	ATP binding site [chemical binding]; other site
378806012591	Mg2+ binding site [ion binding]; other site
378806012592	G-X-G motif; other site
378806012593	circadian clock protein KaiC; Reviewed; Region: PRK09302
378806012594	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806012595	Walker A motif; other site
378806012596	ATP binding site [chemical binding]; other site
378806012597	Walker B motif; other site
378806012598	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806012599	Walker A motif; other site
378806012600	ATP binding site [chemical binding]; other site
378806012601	Walker B motif; other site
378806012602	Histone methylation protein DOT1; Region: DOT1; pfam08123
378806012603	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806012604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
378806012605	intermolecular recognition site; other site
378806012606	active site
378806012607	dimerization interface [polypeptide binding]; other site
378806012608	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
378806012609	G1 box; other site
378806012610	GTP/Mg2+ binding site [chemical binding]; other site
378806012611	Switch I region; other site
378806012612	G3 box; other site
378806012613	Switch II region; other site
378806012614	G4 box; other site
378806012615	G5 box; other site
378806012616	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
378806012617	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806012618	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806012619	dimer interface [polypeptide binding]; other site
378806012620	phosphorylation site [posttranslational modification]
378806012621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012622	ATP binding site [chemical binding]; other site
378806012623	G-X-G motif; other site
378806012624	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
378806012625	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
378806012626	homodimer interface [polypeptide binding]; other site
378806012627	homotetramer interface [polypeptide binding]; other site
378806012628	active site pocket [active]
378806012629	cleavage site
378806012630	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806012631	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806012632	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
378806012633	Protein export membrane protein; Region: SecD_SecF; cl14618
378806012634	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
378806012635	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
378806012636	MarR family; Region: MarR; pfam01047
378806012637	MarR family; Region: MarR_2; cl17246
378806012638	Outer membrane efflux protein; Region: OEP; pfam02321
378806012639	Outer membrane efflux protein; Region: OEP; pfam02321
378806012640	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806012641	Surface antigen; Region: Bac_surface_Ag; pfam01103
378806012642	Protein kinase domain; Region: Pkinase; pfam00069
378806012643	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806012644	active site
378806012645	ATP binding site [chemical binding]; other site
378806012646	substrate binding site [chemical binding]; other site
378806012647	activation loop (A-loop); other site
378806012648	Predicted ATPase [General function prediction only]; Region: COG3899
378806012649	AAA ATPase domain; Region: AAA_16; pfam13191
378806012650	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806012651	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806012652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012653	ATP binding site [chemical binding]; other site
378806012654	Mg2+ binding site [ion binding]; other site
378806012655	G-X-G motif; other site
378806012656	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806012657	Uncharacterized conserved protein [Function unknown]; Region: COG3349
378806012658	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806012659	Uncharacterized conserved protein [Function unknown]; Region: COG3349
378806012660	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
378806012661	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
378806012662	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806012663	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806012664	active site
378806012665	ATP binding site [chemical binding]; other site
378806012666	substrate binding site [chemical binding]; other site
378806012667	activation loop (A-loop); other site
378806012668	Response regulator receiver domain; Region: Response_reg; pfam00072
378806012669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012670	active site
378806012671	phosphorylation site [posttranslational modification]
378806012672	intermolecular recognition site; other site
378806012673	dimerization interface [polypeptide binding]; other site
378806012674	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806012675	cyclase homology domain; Region: CHD; cd07302
378806012676	nucleotidyl binding site; other site
378806012677	metal binding site [ion binding]; metal-binding site
378806012678	dimer interface [polypeptide binding]; other site
378806012679	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806012680	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
378806012681	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
378806012682	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806012683	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
378806012684	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
378806012685	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806012686	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
378806012687	dimer interface [polypeptide binding]; other site
378806012688	active site
378806012689	Schiff base residues; other site
378806012690	Response regulator receiver domain; Region: Response_reg; pfam00072
378806012691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012692	active site
378806012693	phosphorylation site [posttranslational modification]
378806012694	intermolecular recognition site; other site
378806012695	dimerization interface [polypeptide binding]; other site
378806012696	Response regulator receiver domain; Region: Response_reg; pfam00072
378806012697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012698	active site
378806012699	phosphorylation site [posttranslational modification]
378806012700	intermolecular recognition site; other site
378806012701	dimerization interface [polypeptide binding]; other site
378806012702	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
378806012703	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806012704	Walker A/P-loop; other site
378806012705	ATP binding site [chemical binding]; other site
378806012706	Q-loop/lid; other site
378806012707	ABC transporter signature motif; other site
378806012708	Walker B; other site
378806012709	D-loop; other site
378806012710	H-loop/switch region; other site
378806012711	Flagellin N-methylase; Region: FliB; pfam03692
378806012712	Predicted membrane protein [Function unknown]; Region: COG2855
378806012713	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
378806012714	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806012715	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
378806012716	putative dimerization interface [polypeptide binding]; other site
378806012717	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
378806012718	amidase catalytic site [active]
378806012719	Zn binding residues [ion binding]; other site
378806012720	substrate binding site [chemical binding]; other site
378806012721	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
378806012722	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
378806012723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806012724	S-adenosylmethionine binding site [chemical binding]; other site
378806012725	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
378806012726	Uncharacterized conserved protein [Function unknown]; Region: COG4198
378806012727	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
378806012728	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
378806012729	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
378806012730	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806012731	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806012732	binding surface
378806012733	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806012734	TPR motif; other site
378806012735	TPR repeat; Region: TPR_11; pfam13414
378806012736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012737	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
378806012738	active site
378806012739	phosphorylation site [posttranslational modification]
378806012740	dimerization interface [polypeptide binding]; other site
378806012741	CheB methylesterase; Region: CheB_methylest; pfam01339
378806012742	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806012743	putative binding surface; other site
378806012744	active site
378806012745	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012746	ATP binding site [chemical binding]; other site
378806012747	Mg2+ binding site [ion binding]; other site
378806012748	G-X-G motif; other site
378806012749	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
378806012750	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806012751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012752	active site
378806012753	phosphorylation site [posttranslational modification]
378806012754	intermolecular recognition site; other site
378806012755	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806012756	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806012757	dimer interface [polypeptide binding]; other site
378806012758	putative CheW interface [polypeptide binding]; other site
378806012759	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806012760	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806012761	Response regulator receiver domain; Region: Response_reg; pfam00072
378806012762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012763	active site
378806012764	phosphorylation site [posttranslational modification]
378806012765	intermolecular recognition site; other site
378806012766	dimerization interface [polypeptide binding]; other site
378806012767	Response regulator receiver domain; Region: Response_reg; pfam00072
378806012768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012769	active site
378806012770	phosphorylation site [posttranslational modification]
378806012771	intermolecular recognition site; other site
378806012772	dimerization interface [polypeptide binding]; other site
378806012773	Radical SAM superfamily; Region: Radical_SAM; pfam04055
378806012774	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806012775	FeS/SAM binding site; other site
378806012776	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
378806012777	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
378806012778	hexamer interface [polypeptide binding]; other site
378806012779	ligand binding site [chemical binding]; other site
378806012780	putative active site [active]
378806012781	NAD(P) binding site [chemical binding]; other site
378806012782	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
378806012783	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806012784	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806012785	DNA binding residues [nucleotide binding]
378806012786	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
378806012787	Putative zinc-finger; Region: zf-HC2; pfam13490
378806012788	Response regulator receiver domain; Region: Response_reg; pfam00072
378806012789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012790	active site
378806012791	phosphorylation site [posttranslational modification]
378806012792	intermolecular recognition site; other site
378806012793	dimerization interface [polypeptide binding]; other site
378806012794	pantothenate kinase; Provisional; Region: PRK05439
378806012795	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
378806012796	ATP-binding site [chemical binding]; other site
378806012797	CoA-binding site [chemical binding]; other site
378806012798	Mg2+-binding site [ion binding]; other site
378806012799	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
378806012800	nucleotide binding site [chemical binding]; other site
378806012801	Biotin operon repressor [Transcription]; Region: BirA; COG1654
378806012802	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
378806012803	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
378806012804	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
378806012805	homoserine dehydrogenase; Provisional; Region: PRK06349
378806012806	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
378806012807	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
378806012808	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
378806012809	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
378806012810	HEAT repeats; Region: HEAT_2; pfam13646
378806012811	protein binding surface [polypeptide binding]; other site
378806012812	Restriction endonuclease; Region: Mrr_cat; pfam04471
378806012813	PQQ-like domain; Region: PQQ_2; pfam13360
378806012814	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
378806012815	Trp docking motif [polypeptide binding]; other site
378806012816	active site
378806012817	PQQ-like domain; Region: PQQ_2; pfam13360
378806012818	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806012819	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806012820	active site
378806012821	ATP binding site [chemical binding]; other site
378806012822	substrate binding site [chemical binding]; other site
378806012823	activation loop (A-loop); other site
378806012824	polycystin cation channel protein; Region: PCC; TIGR00864
378806012825	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
378806012826	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
378806012827	L-ascorbate oxidase, plant type; Region: ascorbase; TIGR03388
378806012828	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
378806012829	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
378806012830	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
378806012831	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
378806012832	Cu(I) binding site [ion binding]; other site
378806012833	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
378806012834	Cu(I) binding site [ion binding]; other site
378806012835	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
378806012836	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
378806012837	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806012838	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806012839	dimer interface [polypeptide binding]; other site
378806012840	phosphorylation site [posttranslational modification]
378806012841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012842	ATP binding site [chemical binding]; other site
378806012843	Mg2+ binding site [ion binding]; other site
378806012844	G-X-G motif; other site
378806012845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806012846	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806012847	active site
378806012848	phosphorylation site [posttranslational modification]
378806012849	intermolecular recognition site; other site
378806012850	dimerization interface [polypeptide binding]; other site
378806012851	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806012852	DNA binding site [nucleotide binding]
378806012853	O-methyltransferase; Region: Methyltransf_2; pfam00891
378806012854	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
378806012855	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
378806012856	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
378806012857	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
378806012858	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
378806012859	ATP-binding site [chemical binding]; other site
378806012860	Sugar specificity; other site
378806012861	Pyrimidine base specificity; other site
378806012862	Protein of unknown function (DUF692); Region: DUF692; cl01263
378806012863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806012864	S-adenosylmethionine binding site [chemical binding]; other site
378806012865	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806012866	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
378806012867	FtsX-like permease family; Region: FtsX; pfam02687
378806012868	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806012869	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
378806012870	FtsX-like permease family; Region: FtsX; pfam02687
378806012871	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
378806012872	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
378806012873	Walker A/P-loop; other site
378806012874	ATP binding site [chemical binding]; other site
378806012875	Q-loop/lid; other site
378806012876	ABC transporter signature motif; other site
378806012877	Walker B; other site
378806012878	D-loop; other site
378806012879	H-loop/switch region; other site
378806012880	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806012881	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806012882	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806012883	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
378806012884	Yip1 domain; Region: Yip1; pfam04893
378806012885	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806012886	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806012887	Walker A motif; other site
378806012888	ATP binding site [chemical binding]; other site
378806012889	Walker B motif; other site
378806012890	arginine finger; other site
378806012891	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
378806012892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806012893	Walker A motif; other site
378806012894	ATP binding site [chemical binding]; other site
378806012895	Walker B motif; other site
378806012896	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
378806012897	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
378806012898	Cna protein B-type domain; Region: Cna_B_2; pfam13715
378806012899	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
378806012900	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806012901	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806012902	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
378806012903	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806012904	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806012905	catalytic residue [active]
378806012906	Protein of unknown function (DUF1279); Region: DUF1279; pfam06916
378806012907	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
378806012908	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
378806012909	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
378806012910	Predicted peptidase [General function prediction only]; Region: COG4099
378806012911	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806012912	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806012913	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806012914	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806012915	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806012916	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806012917	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806012918	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806012919	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806012920	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806012921	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806012922	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806012923	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806012924	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806012925	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
378806012926	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
378806012927	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806012928	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806012929	active site
378806012930	ATP binding site [chemical binding]; other site
378806012931	substrate binding site [chemical binding]; other site
378806012932	activation loop (A-loop); other site
378806012933	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
378806012934	NAD binding site [chemical binding]; other site
378806012935	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
378806012936	active site
378806012937	GAF domain; Region: GAF_2; pfam13185
378806012938	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806012939	PAS domain; Region: PAS_9; pfam13426
378806012940	putative active site [active]
378806012941	heme pocket [chemical binding]; other site
378806012942	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806012943	PAS fold; Region: PAS_3; pfam08447
378806012944	putative active site [active]
378806012945	heme pocket [chemical binding]; other site
378806012946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806012947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806012948	ATP binding site [chemical binding]; other site
378806012949	Mg2+ binding site [ion binding]; other site
378806012950	G-X-G motif; other site
378806012951	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
378806012952	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
378806012953	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
378806012954	active site
378806012955	(T/H)XGH motif; other site
378806012956	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806012957	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
378806012958	cyclase homology domain; Region: CHD; cd07302
378806012959	dimer interface [polypeptide binding]; other site
378806012960	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806012961	TPR repeat; Region: TPR_11; pfam13414
378806012962	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806012963	binding surface
378806012964	TPR motif; other site
378806012965	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
378806012966	MutS domain III; Region: MutS_III; pfam05192
378806012967	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806012968	Walker A/P-loop; other site
378806012969	ATP binding site [chemical binding]; other site
378806012970	Q-loop/lid; other site
378806012971	ABC transporter signature motif; other site
378806012972	Walker B; other site
378806012973	D-loop; other site
378806012974	H-loop/switch region; other site
378806012975	Smr domain; Region: Smr; pfam01713
378806012976	LabA_like proteins; Region: LabA_like; cd06167
378806012977	putative metal binding site [ion binding]; other site
378806012978	cyclase homology domain; Region: CHD; cd07302
378806012979	nucleotidyl binding site; other site
378806012980	metal binding site [ion binding]; metal-binding site
378806012981	dimer interface [polypeptide binding]; other site
378806012982	Predicted ATPase [General function prediction only]; Region: COG3903
378806012983	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806012984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806012985	binding surface
378806012986	TPR motif; other site
378806012987	GLTT repeat (6 copies); Region: GLTT; pfam01744
378806012988	ribonuclease R; Region: RNase_R; TIGR02063
378806012989	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
378806012990	RNB domain; Region: RNB; pfam00773
378806012991	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
378806012992	RNA binding site [nucleotide binding]; other site
378806012993	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
378806012994	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
378806012995	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
378806012996	dimer interface [polypeptide binding]; other site
378806012997	putative functional site; other site
378806012998	putative MPT binding site; other site
378806012999	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
378806013000	dimerization interface [polypeptide binding]; other site
378806013001	active site
378806013002	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
378806013003	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
378806013004	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
378806013005	nudix motif; other site
378806013006	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
378806013007	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
378806013008	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
378806013009	E3 interaction surface; other site
378806013010	lipoyl attachment site [posttranslational modification]; other site
378806013011	e3 binding domain; Region: E3_binding; pfam02817
378806013012	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
378806013013	lipoyl synthase; Provisional; Region: PRK05481
378806013014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806013015	FeS/SAM binding site; other site
378806013016	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806013017	active site
378806013018	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
378806013019	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
378806013020	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
378806013021	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
378806013022	Uncharacterized conserved protein [Function unknown]; Region: COG1944
378806013023	YcaO-like family; Region: YcaO; pfam02624
378806013024	Methyltransferase domain; Region: Methyltransf_11; pfam08241
378806013025	Acyltransferase family; Region: Acyl_transf_3; pfam01757
378806013026	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
378806013027	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
378806013028	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
378806013029	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
378806013030	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
378806013031	metal binding site [ion binding]; metal-binding site
378806013032	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
378806013033	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
378806013034	substrate binding site [chemical binding]; other site
378806013035	glutamase interaction surface [polypeptide binding]; other site
378806013036	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341
378806013037	putative active site pocket [active]
378806013038	4-fold oligomerization interface [polypeptide binding]; other site
378806013039	metal binding residues [ion binding]; metal-binding site
378806013040	3-fold/trimer interface [polypeptide binding]; other site
378806013041	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
378806013042	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
378806013043	catalytic residues [active]
378806013044	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
378806013045	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
378806013046	putative active site [active]
378806013047	oxyanion strand; other site
378806013048	catalytic triad [active]
378806013049	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
378806013050	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806013051	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806013052	homodimer interface [polypeptide binding]; other site
378806013053	catalytic residue [active]
378806013054	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
378806013055	histidinol dehydrogenase; Region: hisD; TIGR00069
378806013056	NAD binding site [chemical binding]; other site
378806013057	dimerization interface [polypeptide binding]; other site
378806013058	product binding site; other site
378806013059	substrate binding site [chemical binding]; other site
378806013060	zinc binding site [ion binding]; other site
378806013061	catalytic residues [active]
378806013062	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
378806013063	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
378806013064	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
378806013065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013066	active site
378806013067	phosphorylation site [posttranslational modification]
378806013068	intermolecular recognition site; other site
378806013069	dimerization interface [polypeptide binding]; other site
378806013070	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806013071	Zn2+ binding site [ion binding]; other site
378806013072	Mg2+ binding site [ion binding]; other site
378806013073	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
378806013074	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806013075	FeS/SAM binding site; other site
378806013076	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
378806013077	Tic20-like protein; Region: Tic20; pfam09685
378806013078	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
378806013079	ThiC-associated domain; Region: ThiC-associated; pfam13667
378806013080	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
378806013081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806013082	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806013083	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806013084	active site
378806013085	ATP binding site [chemical binding]; other site
378806013086	substrate binding site [chemical binding]; other site
378806013087	activation loop (A-loop); other site
378806013088	AAA ATPase domain; Region: AAA_16; pfam13191
378806013089	Trm112p-like protein; Region: Trm112p; pfam03966
378806013090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806013091	S-adenosylmethionine binding site [chemical binding]; other site
378806013092	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
378806013093	classical (c) SDRs; Region: SDR_c; cd05233
378806013094	NAD(P) binding site [chemical binding]; other site
378806013095	active site
378806013096	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
378806013097	putative acyl-acceptor binding pocket; other site
378806013098	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
378806013099	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
378806013100	active site
378806013101	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
378806013102	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
378806013103	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
378806013104	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
378806013105	nucleophile elbow; other site
378806013106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806013107	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806013108	Walker A motif; other site
378806013109	ATP binding site [chemical binding]; other site
378806013110	Walker B motif; other site
378806013111	arginine finger; other site
378806013112	tetracycline repressor protein TetR; Provisional; Region: PRK13756
378806013113	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806013114	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
378806013115	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806013116	hypothetical protein; Provisional; Region: PRK06184
378806013117	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
378806013118	Pirin-related protein [General function prediction only]; Region: COG1741
378806013119	Pirin; Region: Pirin; pfam02678
378806013120	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
378806013121	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
378806013122	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
378806013123	NAD(P) binding site [chemical binding]; other site
378806013124	PilZ domain; Region: PilZ; pfam07238
378806013125	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
378806013126	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806013127	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806013128	protein binding site [polypeptide binding]; other site
378806013129	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806013130	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
378806013131	protein binding site [polypeptide binding]; other site
378806013132	GrpE; Region: GrpE; pfam01025
378806013133	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
378806013134	dimer interface [polypeptide binding]; other site
378806013135	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
378806013136	FtsH Extracellular; Region: FtsH_ext; pfam06480
378806013137	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
378806013138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806013139	Walker A motif; other site
378806013140	ATP binding site [chemical binding]; other site
378806013141	Walker B motif; other site
378806013142	arginine finger; other site
378806013143	Peptidase family M41; Region: Peptidase_M41; pfam01434
378806013144	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
378806013145	active site
378806013146	8-oxo-dGMP binding site [chemical binding]; other site
378806013147	nudix motif; other site
378806013148	metal binding site [ion binding]; metal-binding site
378806013149	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806013150	active site
378806013151	ATP binding site [chemical binding]; other site
378806013152	substrate binding site [chemical binding]; other site
378806013153	activation loop (A-loop); other site
378806013154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806013155	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806013156	non-specific DNA binding site [nucleotide binding]; other site
378806013157	sequence-specific DNA binding site [nucleotide binding]; other site
378806013158	salt bridge; other site
378806013159	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
378806013160	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
378806013161	putative molybdopterin cofactor binding site [chemical binding]; other site
378806013162	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
378806013163	putative molybdopterin cofactor binding site; other site
378806013164	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
378806013165	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
378806013166	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
378806013167	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
378806013168	putative CheA interaction surface; other site
378806013169	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806013170	putative binding surface; other site
378806013171	active site
378806013172	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
378806013173	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
378806013174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806013175	ATP binding site [chemical binding]; other site
378806013176	Mg2+ binding site [ion binding]; other site
378806013177	G-X-G motif; other site
378806013178	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
378806013179	GAF domain; Region: GAF_3; pfam13492
378806013180	CheD chemotactic sensory transduction; Region: CheD; cl00810
378806013181	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013183	active site
378806013184	phosphorylation site [posttranslational modification]
378806013185	intermolecular recognition site; other site
378806013186	dimerization interface [polypeptide binding]; other site
378806013187	urocanate hydratase; Provisional; Region: PRK05414
378806013188	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
378806013189	imidazolonepropionase; Region: hutI; TIGR01224
378806013190	active site
378806013191	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
378806013192	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
378806013193	putative active site [active]
378806013194	putative dimer interface [polypeptide binding]; other site
378806013195	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
378806013196	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
378806013197	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
378806013198	putative substrate binding site [chemical binding]; other site
378806013199	putative ATP binding site [chemical binding]; other site
378806013200	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
378806013201	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
378806013202	active site
378806013203	hydrophilic channel; other site
378806013204	dimerization interface [polypeptide binding]; other site
378806013205	catalytic residues [active]
378806013206	active site lid [active]
378806013207	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
378806013208	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
378806013209	active site
378806013210	substrate binding site [chemical binding]; other site
378806013211	metal binding site [ion binding]; metal-binding site
378806013212	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
378806013213	dihydropteroate synthase; Region: DHPS; TIGR01496
378806013214	substrate binding pocket [chemical binding]; other site
378806013215	dimer interface [polypeptide binding]; other site
378806013216	inhibitor binding site; inhibition site
378806013217	FtsH Extracellular; Region: FtsH_ext; pfam06480
378806013218	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
378806013219	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
378806013220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806013221	Walker A motif; other site
378806013222	ATP binding site [chemical binding]; other site
378806013223	Walker B motif; other site
378806013224	arginine finger; other site
378806013225	Peptidase family M41; Region: Peptidase_M41; pfam01434
378806013226	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
378806013227	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
378806013228	Ligand Binding Site [chemical binding]; other site
378806013229	TilS substrate C-terminal domain; Region: TilS_C; smart00977
378806013230	Protein of unknown function, DUF399; Region: DUF399; cl01139
378806013231	Protein of unknown function (DUF419); Region: DUF419; pfam04237
378806013232	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
378806013233	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
378806013234	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
378806013235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806013236	S-adenosylmethionine binding site [chemical binding]; other site
378806013237	Methyltransferase domain; Region: Methyltransf_31; pfam13847
378806013238	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806013239	classical (c) SDRs; Region: SDR_c; cd05233
378806013240	NAD(P) binding site [chemical binding]; other site
378806013241	active site
378806013242	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
378806013243	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
378806013244	active site 2 [active]
378806013245	active site 1 [active]
378806013246	B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067
378806013247	B12 binding site [chemical binding]; other site
378806013248	cobalt ligand [ion binding]; other site
378806013249	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
378806013250	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
378806013251	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
378806013252	tetramer interface [polypeptide binding]; other site
378806013253	heme binding pocket [chemical binding]; other site
378806013254	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
378806013255	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
378806013256	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
378806013257	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
378806013258	NAD(P) binding site [chemical binding]; other site
378806013259	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
378806013260	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
378806013261	Fe-S cluster binding site [ion binding]; other site
378806013262	active site
378806013263	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
378806013264	Flavoprotein; Region: Flavoprotein; pfam02441
378806013265	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
378806013266	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806013267	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806013268	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806013269	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806013270	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806013271	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806013272	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806013273	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806013274	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
378806013275	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
378806013276	FAD binding pocket [chemical binding]; other site
378806013277	FAD binding motif [chemical binding]; other site
378806013278	phosphate binding motif [ion binding]; other site
378806013279	NAD binding pocket [chemical binding]; other site
378806013280	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
378806013281	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
378806013282	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806013283	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
378806013284	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
378806013285	putative ligand binding site [chemical binding]; other site
378806013286	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
378806013287	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
378806013288	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806013289	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806013290	catalytic residue [active]
378806013291	Protein phosphatase 2C; Region: PP2C; pfam00481
378806013292	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
378806013293	active site
378806013294	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806013295	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806013296	ligand binding site [chemical binding]; other site
378806013297	flexible hinge region; other site
378806013298	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
378806013299	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806013300	putative active site [active]
378806013301	heme pocket [chemical binding]; other site
378806013302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806013303	dimer interface [polypeptide binding]; other site
378806013304	phosphorylation site [posttranslational modification]
378806013305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806013306	ATP binding site [chemical binding]; other site
378806013307	Mg2+ binding site [ion binding]; other site
378806013308	G-X-G motif; other site
378806013309	CAAX protease self-immunity; Region: Abi; pfam02517
378806013310	Sulfatase; Region: Sulfatase; cl17466
378806013311	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
378806013312	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806013313	Interdomain contacts; other site
378806013314	Cytokine receptor motif; other site
378806013315	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806013316	Interdomain contacts; other site
378806013317	Cytokine receptor motif; other site
378806013318	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
378806013319	Glyco_18 domain; Region: Glyco_18; smart00636
378806013320	active site
378806013321	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
378806013322	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
378806013323	catalytic residue [active]
378806013324	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
378806013325	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806013326	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806013327	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
378806013328	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
378806013329	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
378806013330	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
378806013331	Domain of unknown function (DUF329); Region: DUF329; pfam03884
378806013332	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
378806013333	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
378806013334	NAD(P) binding site [chemical binding]; other site
378806013335	agmatinase; Region: agmatinase; TIGR01230
378806013336	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
378806013337	putative active site [active]
378806013338	Mn binding site [ion binding]; other site
378806013339	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013341	active site
378806013342	phosphorylation site [posttranslational modification]
378806013343	intermolecular recognition site; other site
378806013344	dimerization interface [polypeptide binding]; other site
378806013345	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806013346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806013347	ATP binding site [chemical binding]; other site
378806013348	Mg2+ binding site [ion binding]; other site
378806013349	G-X-G motif; other site
378806013350	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
378806013351	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806013352	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806013353	protein binding site [polypeptide binding]; other site
378806013354	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806013355	protein binding site [polypeptide binding]; other site
378806013356	Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219
378806013357	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806013358	active site
378806013359	ATP binding site [chemical binding]; other site
378806013360	substrate binding site [chemical binding]; other site
378806013361	activation loop (A-loop); other site
378806013362	PEGA domain; Region: PEGA; pfam08308
378806013363	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806013364	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806013365	active site
378806013366	ATP binding site [chemical binding]; other site
378806013367	substrate binding site [chemical binding]; other site
378806013368	activation loop (A-loop); other site
378806013369	PEGA domain; Region: PEGA; pfam08308
378806013370	PEGA domain; Region: PEGA; pfam08308
378806013371	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
378806013372	GAF domain; Region: GAF; cl17456
378806013373	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806013374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806013375	Walker A motif; other site
378806013376	ATP binding site [chemical binding]; other site
378806013377	Walker B motif; other site
378806013378	arginine finger; other site
378806013379	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
378806013380	hypothetical protein; Provisional; Region: PRK11770
378806013381	Domain of unknown function (DUF307); Region: DUF307; pfam03733
378806013382	Domain of unknown function (DUF307); Region: DUF307; pfam03733
378806013383	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806013384	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806013385	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
378806013386	active site
378806013387	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013389	active site
378806013390	phosphorylation site [posttranslational modification]
378806013391	intermolecular recognition site; other site
378806013392	dimerization interface [polypeptide binding]; other site
378806013393	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
378806013394	FecR protein; Region: FecR; pfam04773
378806013395	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806013396	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806013397	dimerization interface [polypeptide binding]; other site
378806013398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806013399	phosphorylation site [posttranslational modification]
378806013400	dimer interface [polypeptide binding]; other site
378806013401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806013402	ATP binding site [chemical binding]; other site
378806013403	Mg2+ binding site [ion binding]; other site
378806013404	G-X-G motif; other site
378806013405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013406	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013407	active site
378806013408	phosphorylation site [posttranslational modification]
378806013409	intermolecular recognition site; other site
378806013410	dimerization interface [polypeptide binding]; other site
378806013411	GAF domain; Region: GAF_3; pfam13492
378806013412	GAF domain; Region: GAF_2; pfam13185
378806013413	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806013414	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806013415	putative active site [active]
378806013416	heme pocket [chemical binding]; other site
378806013417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806013418	dimer interface [polypeptide binding]; other site
378806013419	phosphorylation site [posttranslational modification]
378806013420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806013421	ATP binding site [chemical binding]; other site
378806013422	Mg2+ binding site [ion binding]; other site
378806013423	G-X-G motif; other site
378806013424	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013426	active site
378806013427	phosphorylation site [posttranslational modification]
378806013428	intermolecular recognition site; other site
378806013429	dimerization interface [polypeptide binding]; other site
378806013430	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013432	active site
378806013433	phosphorylation site [posttranslational modification]
378806013434	intermolecular recognition site; other site
378806013435	dimerization interface [polypeptide binding]; other site
378806013436	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806013437	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806013438	metal binding site [ion binding]; metal-binding site
378806013439	active site
378806013440	I-site; other site
378806013441	LexA repressor; Validated; Region: PRK00215
378806013442	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
378806013443	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
378806013444	Catalytic site [active]
378806013445	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806013446	TPR motif; other site
378806013447	binding surface
378806013448	TPR repeat; Region: TPR_11; pfam13414
378806013449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806013450	binding surface
378806013451	TPR motif; other site
378806013452	TPR repeat; Region: TPR_11; pfam13414
378806013453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806013454	binding surface
378806013455	TPR motif; other site
378806013456	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
378806013457	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806013458	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
378806013459	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806013460	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
378806013461	enolase; Provisional; Region: eno; PRK00077
378806013462	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
378806013463	dimer interface [polypeptide binding]; other site
378806013464	metal binding site [ion binding]; metal-binding site
378806013465	substrate binding pocket [chemical binding]; other site
378806013466	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
378806013467	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
378806013468	hydrophobic ligand binding site; other site
378806013469	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
378806013470	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
378806013471	putative active site [active]
378806013472	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
378806013473	active site
378806013474	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
378806013475	nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078
378806013476	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
378806013477	dimerization interface [polypeptide binding]; other site
378806013478	active site
378806013479	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
378806013480	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806013481	active site
378806013482	HIGH motif; other site
378806013483	nucleotide binding site [chemical binding]; other site
378806013484	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
378806013485	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
378806013486	active site
378806013487	KMSKS motif; other site
378806013488	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
378806013489	tRNA binding surface [nucleotide binding]; other site
378806013490	anticodon binding site; other site
378806013491	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
378806013492	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013494	active site
378806013495	phosphorylation site [posttranslational modification]
378806013496	intermolecular recognition site; other site
378806013497	dimerization interface [polypeptide binding]; other site
378806013498	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013500	active site
378806013501	phosphorylation site [posttranslational modification]
378806013502	intermolecular recognition site; other site
378806013503	dimerization interface [polypeptide binding]; other site
378806013504	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806013505	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806013506	metal binding site [ion binding]; metal-binding site
378806013507	active site
378806013508	I-site; other site
378806013509	Uncharacterized conserved protein [Function unknown]; Region: COG3461
378806013510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806013511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806013512	dimer interface [polypeptide binding]; other site
378806013513	phosphorylation site [posttranslational modification]
378806013514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806013515	ATP binding site [chemical binding]; other site
378806013516	G-X-G motif; other site
378806013517	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013519	active site
378806013520	phosphorylation site [posttranslational modification]
378806013521	intermolecular recognition site; other site
378806013522	dimerization interface [polypeptide binding]; other site
378806013523	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806013524	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
378806013525	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
378806013526	ring oligomerisation interface [polypeptide binding]; other site
378806013527	ATP/Mg binding site [chemical binding]; other site
378806013528	stacking interactions; other site
378806013529	hinge regions; other site
378806013530	Response regulator receiver domain; Region: Response_reg; pfam00072
378806013531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013532	active site
378806013533	phosphorylation site [posttranslational modification]
378806013534	intermolecular recognition site; other site
378806013535	dimerization interface [polypeptide binding]; other site
378806013536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806013537	binding surface
378806013538	TPR motif; other site
378806013539	TPR repeat; Region: TPR_11; pfam13414
378806013540	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
378806013541	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806013542	active site
378806013543	ATP binding site [chemical binding]; other site
378806013544	substrate binding site [chemical binding]; other site
378806013545	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806013546	activation loop (A-loop); other site
378806013547	activation loop (A-loop); other site
378806013548	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806013549	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806013550	non-specific DNA binding site [nucleotide binding]; other site
378806013551	salt bridge; other site
378806013552	sequence-specific DNA binding site [nucleotide binding]; other site
378806013553	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
378806013554	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
378806013555	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806013556	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806013557	active site
378806013558	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806013559	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806013560	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806013561	active site
378806013562	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806013563	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806013564	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806013565	KR domain; Region: KR; pfam08659
378806013566	putative NADP binding site [chemical binding]; other site
378806013567	active site
378806013568	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806013569	bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975
378806013570	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
378806013571	B12 binding site [chemical binding]; other site
378806013572	Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828
378806013573	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806013574	KR domain; Region: KR; pfam08659
378806013575	putative NADP binding site [chemical binding]; other site
378806013576	active site
378806013577	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806013578	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
378806013579	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
378806013580	DTAP/Switch II; other site
378806013581	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
378806013582	active site
378806013583	nucleophile elbow; other site
378806013584	Condensation domain; Region: Condensation; pfam00668
378806013585	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806013586	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806013587	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806013588	acyl-activating enzyme (AAE) consensus motif; other site
378806013589	AMP binding site [chemical binding]; other site
378806013590	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806013591	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
378806013592	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806013593	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806013594	active site
378806013595	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806013596	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806013597	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806013598	putative NADP binding site [chemical binding]; other site
378806013599	KR domain; Region: KR; pfam08659
378806013600	active site
378806013601	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806013602	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806013603	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806013604	active site
378806013605	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806013606	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806013607	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806013608	putative NADP binding site [chemical binding]; other site
378806013609	KR domain; Region: KR; pfam08659
378806013610	active site
378806013611	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806013612	Condensation domain; Region: Condensation; pfam00668
378806013613	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806013614	Nonribosomal peptide synthase; Region: NRPS; pfam08415
378806013615	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
378806013616	acyl-activating enzyme (AAE) consensus motif; other site
378806013617	AMP binding site [chemical binding]; other site
378806013618	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806013619	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806013620	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806013621	active site
378806013622	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806013623	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806013624	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806013625	putative NADP binding site [chemical binding]; other site
378806013626	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806013627	active site
378806013628	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806013629	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806013630	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806013631	active site
378806013632	Acyl transferase domain; Region: Acyl_transf_1; cl08282
378806013633	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806013634	putative NADP binding site [chemical binding]; other site
378806013635	KR domain; Region: KR; pfam08659
378806013636	active site
378806013637	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806013638	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806013639	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806013640	active site
378806013641	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806013642	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806013643	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806013644	active site
378806013645	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
378806013646	AMP-binding enzyme; Region: AMP-binding; pfam00501
378806013647	acyl-activating enzyme (AAE) consensus motif; other site
378806013648	AMP binding site [chemical binding]; other site
378806013649	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806013650	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
378806013651	Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843
378806013652	MbtH-like protein; Region: MbtH; cl01279
378806013653	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806013654	Coenzyme A binding pocket [chemical binding]; other site
378806013655	Condensation domain; Region: Condensation; pfam00668
378806013656	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806013657	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806013658	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
378806013659	acyl-activating enzyme (AAE) consensus motif; other site
378806013660	AMP binding site [chemical binding]; other site
378806013661	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806013662	Condensation domain; Region: Condensation; pfam00668
378806013663	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806013664	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806013665	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806013666	acyl-activating enzyme (AAE) consensus motif; other site
378806013667	AMP binding site [chemical binding]; other site
378806013668	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806013669	Condensation domain; Region: Condensation; pfam00668
378806013670	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806013671	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806013672	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806013673	acyl-activating enzyme (AAE) consensus motif; other site
378806013674	AMP binding site [chemical binding]; other site
378806013675	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806013676	acyl-CoA synthetase; Validated; Region: PRK05850
378806013677	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806013678	acyl-activating enzyme (AAE) consensus motif; other site
378806013679	active site
378806013680	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806013681	Condensation domain; Region: Condensation; pfam00668
378806013682	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806013683	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806013684	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
378806013685	acyl-activating enzyme (AAE) consensus motif; other site
378806013686	AMP binding site [chemical binding]; other site
378806013687	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806013688	Condensation domain; Region: Condensation; pfam00668
378806013689	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806013690	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806013691	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806013692	acyl-activating enzyme (AAE) consensus motif; other site
378806013693	AMP binding site [chemical binding]; other site
378806013694	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806013695	Condensation domain; Region: Condensation; pfam00668
378806013696	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806013697	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806013698	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806013699	acyl-activating enzyme (AAE) consensus motif; other site
378806013700	AMP binding site [chemical binding]; other site
378806013701	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806013702	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806013703	M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875
378806013704	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806013705	metal binding site [ion binding]; metal-binding site
378806013706	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
378806013707	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806013708	Walker A/P-loop; other site
378806013709	ATP binding site [chemical binding]; other site
378806013710	Q-loop/lid; other site
378806013711	ABC transporter signature motif; other site
378806013712	Walker B; other site
378806013713	D-loop; other site
378806013714	H-loop/switch region; other site
378806013715	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
378806013716	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
378806013717	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
378806013718	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
378806013719	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
378806013720	dimer interface [polypeptide binding]; other site
378806013721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806013722	catalytic residue [active]
378806013723	Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165
378806013724	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
378806013725	active sites [active]
378806013726	tetramer interface [polypeptide binding]; other site
378806013727	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
378806013728	putative deacylase active site [active]
378806013729	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
378806013730	helicase 45; Provisional; Region: PTZ00424
378806013731	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
378806013732	ATP binding site [chemical binding]; other site
378806013733	Mg++ binding site [ion binding]; other site
378806013734	motif III; other site
378806013735	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806013736	nucleotide binding region [chemical binding]; other site
378806013737	ATP-binding site [chemical binding]; other site
378806013738	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
378806013739	RNA binding site [nucleotide binding]; other site
378806013740	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
378806013741	catalytic core [active]
378806013742	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806013743	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806013744	ligand binding site [chemical binding]; other site
378806013745	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806013746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013747	active site
378806013748	phosphorylation site [posttranslational modification]
378806013749	intermolecular recognition site; other site
378806013750	dimerization interface [polypeptide binding]; other site
378806013751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806013752	Walker A motif; other site
378806013753	ATP binding site [chemical binding]; other site
378806013754	Walker B motif; other site
378806013755	arginine finger; other site
378806013756	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806013757	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806013758	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806013759	dimer interface [polypeptide binding]; other site
378806013760	phosphorylation site [posttranslational modification]
378806013761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806013762	ATP binding site [chemical binding]; other site
378806013763	G-X-G motif; other site
378806013764	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
378806013765	B12 binding site [chemical binding]; other site
378806013766	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
378806013767	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806013768	FeS/SAM binding site; other site
378806013769	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
378806013770	dinuclear metal binding motif [ion binding]; other site
378806013771	cyclase homology domain; Region: CHD; cd07302
378806013772	nucleotidyl binding site; other site
378806013773	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806013774	metal binding site [ion binding]; metal-binding site
378806013775	dimer interface [polypeptide binding]; other site
378806013776	cyclase homology domain; Region: CHD; cd07302
378806013777	nucleotidyl binding site; other site
378806013778	dimer interface [polypeptide binding]; other site
378806013779	metal binding site [ion binding]; metal-binding site
378806013780	AAA ATPase domain; Region: AAA_16; pfam13191
378806013781	MutS domain III; Region: MutS_III; cl17822
378806013782	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806013783	binding surface
378806013784	TPR motif; other site
378806013785	TPR repeat; Region: TPR_11; pfam13414
378806013786	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
378806013787	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
378806013788	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806013789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806013790	homodimer interface [polypeptide binding]; other site
378806013791	catalytic residue [active]
378806013792	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
378806013793	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
378806013794	alpha subunit interface [polypeptide binding]; other site
378806013795	TPP binding site [chemical binding]; other site
378806013796	heterodimer interface [polypeptide binding]; other site
378806013797	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
378806013798	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
378806013799	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
378806013800	TPP-binding site [chemical binding]; other site
378806013801	tetramer interface [polypeptide binding]; other site
378806013802	heterodimer interface [polypeptide binding]; other site
378806013803	phosphorylation loop region [posttranslational modification]
378806013804	3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065
378806013805	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
378806013806	substrate binding site [chemical binding]; other site
378806013807	ligand binding site [chemical binding]; other site
378806013808	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
378806013809	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
378806013810	substrate binding site [chemical binding]; other site
378806013811	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
378806013812	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174
378806013813	active site
378806013814	catalytic residues [active]
378806013815	metal binding site [ion binding]; metal-binding site
378806013816	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
378806013817	tartrate dehydrogenase; Region: TTC; TIGR02089
378806013818	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
378806013819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806013820	S-adenosylmethionine binding site [chemical binding]; other site
378806013821	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
378806013822	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806013823	active site
378806013824	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
378806013825	Cytochrome c; Region: Cytochrom_C; pfam00034
378806013826	Cytochrome c; Region: Cytochrom_C; pfam00034
378806013827	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806013828	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806013829	active site
378806013830	ATP binding site [chemical binding]; other site
378806013831	substrate binding site [chemical binding]; other site
378806013832	activation loop (A-loop); other site
378806013833	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
378806013834	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
378806013835	N-terminal plug; other site
378806013836	ligand-binding site [chemical binding]; other site
378806013837	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
378806013838	substrate binding pocket [chemical binding]; other site
378806013839	membrane-bound complex binding site; other site
378806013840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806013841	binding surface
378806013842	TPR motif; other site
378806013843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806013844	TPR motif; other site
378806013845	binding surface
378806013846	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806013847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806013848	binding surface
378806013849	TPR motif; other site
378806013850	TPR repeat; Region: TPR_11; pfam13414
378806013851	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806013852	dimerization interface [polypeptide binding]; other site
378806013853	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
378806013854	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
378806013855	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
378806013856	tetramer interface [polypeptide binding]; other site
378806013857	TPP-binding site [chemical binding]; other site
378806013858	heterodimer interface [polypeptide binding]; other site
378806013859	phosphorylation loop region [posttranslational modification]
378806013860	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
378806013861	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
378806013862	PYR/PP interface [polypeptide binding]; other site
378806013863	dimer interface [polypeptide binding]; other site
378806013864	TPP binding site [chemical binding]; other site
378806013865	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
378806013866	putative acetyltransferase; Provisional; Region: PRK03624
378806013867	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806013868	Coenzyme A binding pocket [chemical binding]; other site
378806013869	PilZ domain; Region: PilZ; cl01260
378806013870	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
378806013871	active site
378806013872	catalytic triad [active]
378806013873	oxyanion hole [active]
378806013874	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
378806013875	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
378806013876	Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250
378806013877	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806013878	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806013879	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
378806013880	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806013881	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806013882	active site
378806013883	metal binding site [ion binding]; metal-binding site
378806013884	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
378806013885	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
378806013886	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
378806013887	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
378806013888	active site
378806013889	Zn binding site [ion binding]; other site
378806013890	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806013891	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806013892	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
378806013893	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
378806013894	minor groove reading motif; other site
378806013895	helix-hairpin-helix signature motif; other site
378806013896	substrate binding pocket [chemical binding]; other site
378806013897	active site
378806013898	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
378806013899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806013900	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
378806013901	Walker A/P-loop; other site
378806013902	ATP binding site [chemical binding]; other site
378806013903	Q-loop/lid; other site
378806013904	ABC transporter signature motif; other site
378806013905	Walker B; other site
378806013906	D-loop; other site
378806013907	H-loop/switch region; other site
378806013908	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806013909	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
378806013910	TM-ABC transporter signature motif; other site
378806013911	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
378806013912	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
378806013913	putative ligand binding site [chemical binding]; other site
378806013914	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
378806013915	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
378806013916	substrate binding site [chemical binding]; other site
378806013917	ATP binding site [chemical binding]; other site
378806013918	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
378806013919	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
378806013920	arogenate dehydrogenase; Region: PLN02256
378806013921	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
378806013922	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
378806013923	Peptidase family U32; Region: Peptidase_U32; pfam01136
378806013924	Collagenase; Region: DUF3656; pfam12392
378806013925	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
378806013926	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806013927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806013928	dimer interface [polypeptide binding]; other site
378806013929	phosphorylation site [posttranslational modification]
378806013930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806013931	ATP binding site [chemical binding]; other site
378806013932	Mg2+ binding site [ion binding]; other site
378806013933	G-X-G motif; other site
378806013934	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806013935	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806013936	dimer interface [polypeptide binding]; other site
378806013937	phosphorylation site [posttranslational modification]
378806013938	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806013939	ATP binding site [chemical binding]; other site
378806013940	G-X-G motif; other site
378806013941	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806013942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806013943	active site
378806013944	phosphorylation site [posttranslational modification]
378806013945	intermolecular recognition site; other site
378806013946	dimerization interface [polypeptide binding]; other site
378806013947	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806013948	DNA binding site [nucleotide binding]
378806013949	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806013950	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
378806013951	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
378806013952	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806013953	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806013954	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806013955	active site
378806013956	ATP binding site [chemical binding]; other site
378806013957	substrate binding site [chemical binding]; other site
378806013958	activation loop (A-loop); other site
378806013959	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806013960	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
378806013961	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806013962	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806013963	DNA-binding site [nucleotide binding]; DNA binding site
378806013964	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
378806013965	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806013966	DDE superfamily endonuclease; Region: DDE_5; cl17874
378806013967	Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693
378806013968	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
378806013969	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
378806013970	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806013971	binding surface
378806013972	TPR motif; other site
378806013973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806013974	TPR motif; other site
378806013975	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806013976	binding surface
378806013977	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
378806013978	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
378806013979	putative hydrophobic ligand binding site [chemical binding]; other site
378806013980	protein interface [polypeptide binding]; other site
378806013981	gate; other site
378806013982	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806013983	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806013984	NAD(P) binding site [chemical binding]; other site
378806013985	active site
378806013986	Transcriptional regulators [Transcription]; Region: MarR; COG1846
378806013987	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
378806013988	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
378806013989	HflX GTPase family; Region: HflX; cd01878
378806013990	G1 box; other site
378806013991	GTP/Mg2+ binding site [chemical binding]; other site
378806013992	Switch I region; other site
378806013993	G2 box; other site
378806013994	G3 box; other site
378806013995	Switch II region; other site
378806013996	G4 box; other site
378806013997	G5 box; other site
378806013998	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806013999	Uncharacterized conserved protein [Function unknown]; Region: COG3349
378806014000	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
378806014001	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
378806014002	peptide synthase; Provisional; Region: PRK12316
378806014003	Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423
378806014004	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
378806014005	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
378806014006	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
378806014007	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806014008	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
378806014009	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
378806014010	ligand binding site; other site
378806014011	oligomer interface; other site
378806014012	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
378806014013	dimer interface [polypeptide binding]; other site
378806014014	N-terminal domain interface [polypeptide binding]; other site
378806014015	sulfate 1 binding site; other site
378806014016	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
378806014017	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
378806014018	Right handed beta helix region; Region: Beta_helix; pfam13229
378806014019	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
378806014020	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806014021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806014022	active site
378806014023	phosphorylation site [posttranslational modification]
378806014024	intermolecular recognition site; other site
378806014025	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806014026	DNA binding residues [nucleotide binding]
378806014027	dimerization interface [polypeptide binding]; other site
378806014028	RDD family; Region: RDD; pfam06271
378806014029	Integral membrane protein DUF95; Region: DUF95; pfam01944
378806014030	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806014031	HSP70 interaction site [polypeptide binding]; other site
378806014032	HEAT repeats; Region: HEAT_2; pfam13646
378806014033	PQQ-like domain; Region: PQQ_2; pfam13360
378806014034	Beta-propeller repeat; Region: SBBP; pfam06739
378806014035	von Willebrand factor (vWF) type D domain; Region: VWD; smart00216
378806014036	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806014037	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806014038	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806014039	calcium binding site 2 [ion binding]; other site
378806014040	active site
378806014041	catalytic triad [active]
378806014042	calcium binding site 1 [ion binding]; other site
378806014043	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806014044	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806014045	HEAT repeats; Region: HEAT_2; pfam13646
378806014046	HEAT repeats; Region: HEAT_2; pfam13646
378806014047	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
378806014048	protein-splicing catalytic site; other site
378806014049	thioester formation/cholesterol transfer; other site
378806014050	Beta-propeller repeat; Region: SBBP; pfam06739
378806014051	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
378806014052	protein-splicing catalytic site; other site
378806014053	thioester formation/cholesterol transfer; other site
378806014054	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
378806014055	pyrroline-5-carboxylate reductase; Region: PLN02688
378806014056	DivIVA protein; Region: DivIVA; pfam05103
378806014057	DivIVA domain; Region: DivI1A_domain; TIGR03544
378806014058	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
378806014059	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
378806014060	DNA polymerase I; Provisional; Region: PRK05755
378806014061	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
378806014062	active site
378806014063	metal binding site 1 [ion binding]; metal-binding site
378806014064	putative 5' ssDNA interaction site; other site
378806014065	metal binding site 3; metal-binding site
378806014066	metal binding site 2 [ion binding]; metal-binding site
378806014067	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
378806014068	putative DNA binding site [nucleotide binding]; other site
378806014069	putative metal binding site [ion binding]; other site
378806014070	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
378806014071	active site
378806014072	catalytic site [active]
378806014073	substrate binding site [chemical binding]; other site
378806014074	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
378806014075	active site
378806014076	DNA binding site [nucleotide binding]
378806014077	catalytic site [active]
378806014078	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
378806014079	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806014080	DDE superfamily endonuclease; Region: DDE_3; pfam13358
378806014081	Homeodomain-like domain; Region: HTH_23; cl17451
378806014082	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
378806014083	Winged helix-turn helix; Region: HTH_33; pfam13592
378806014084	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806014085	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806014086	active site
378806014087	ATP binding site [chemical binding]; other site
378806014088	substrate binding site [chemical binding]; other site
378806014089	activation loop (A-loop); other site
378806014090	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
378806014091	Part of AAA domain; Region: AAA_19; pfam13245
378806014092	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
378806014093	AAA domain; Region: AAA_12; pfam13087
378806014094	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
378806014095	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806014096	FeS/SAM binding site; other site
378806014097	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
378806014098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806014099	Walker A motif; other site
378806014100	ATP binding site [chemical binding]; other site
378806014101	Walker B motif; other site
378806014102	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
378806014103	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
378806014104	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
378806014105	Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848
378806014106	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
378806014107	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806014108	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806014109	phosphopeptide binding site; other site
378806014110	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806014111	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806014112	phosphopeptide binding site; other site
378806014113	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806014114	phosphopeptide binding site; other site
378806014115	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
378806014116	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
378806014117	ATP binding site [chemical binding]; other site
378806014118	Walker A motif; other site
378806014119	hexamer interface [polypeptide binding]; other site
378806014120	Walker B motif; other site
378806014121	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
378806014122	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
378806014123	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
378806014124	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
378806014125	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806014126	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806014127	phosphopeptide binding site; other site
378806014128	Uncharacterized conserved protein [Function unknown]; Region: COG3391
378806014129	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
378806014130	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
378806014131	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
378806014132	dimer interface [polypeptide binding]; other site
378806014133	motif 1; other site
378806014134	active site
378806014135	motif 2; other site
378806014136	motif 3; other site
378806014137	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806014138	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806014139	active site
378806014140	ATP binding site [chemical binding]; other site
378806014141	substrate binding site [chemical binding]; other site
378806014142	activation loop (A-loop); other site
378806014143	PEGA domain; Region: PEGA; pfam08308
378806014144	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
378806014145	active site
378806014146	Phosphopantetheine attachment site; Region: PP-binding; cl09936
378806014147	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806014148	AMP-binding enzyme; Region: AMP-binding; pfam00501
378806014149	acyl-activating enzyme (AAE) consensus motif; other site
378806014150	active site
378806014151	AMP binding site [chemical binding]; other site
378806014152	CoA binding site [chemical binding]; other site
378806014153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806014154	active site
378806014155	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806014156	acyl-CoA synthetase; Validated; Region: PRK05850
378806014157	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806014158	acyl-activating enzyme (AAE) consensus motif; other site
378806014159	active site
378806014160	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014161	Condensation domain; Region: Condensation; pfam00668
378806014162	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806014163	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806014164	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
378806014165	acyl-activating enzyme (AAE) consensus motif; other site
378806014166	AMP binding site [chemical binding]; other site
378806014167	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806014168	Condensation domain; Region: Condensation; pfam00668
378806014169	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806014170	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806014171	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806014172	Condensation domain; Region: Condensation; pfam00668
378806014173	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
378806014174	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806014175	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806014176	SCP-2 sterol transfer family; Region: SCP2; pfam02036
378806014177	Cupin-like domain; Region: Cupin_8; pfam13621
378806014178	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806014179	Coenzyme A binding pocket [chemical binding]; other site
378806014180	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806014181	classical (c) SDRs; Region: SDR_c; cd05233
378806014182	NAD(P) binding site [chemical binding]; other site
378806014183	active site
378806014184	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
378806014185	Cupin domain; Region: Cupin_2; pfam07883
378806014186	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806014187	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806014188	DNA binding residues [nucleotide binding]
378806014189	dimerization interface [polypeptide binding]; other site
378806014190	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
378806014191	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
378806014192	metal ion-dependent adhesion site (MIDAS); other site
378806014193	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
378806014194	Recombination protein O N terminal; Region: RecO_N; pfam11967
378806014195	Recombination protein O C terminal; Region: RecO_C; pfam02565
378806014196	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806014197	non-specific DNA binding site [nucleotide binding]; other site
378806014198	salt bridge; other site
378806014199	sequence-specific DNA binding site [nucleotide binding]; other site
378806014200	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806014201	TPR repeat; Region: TPR_11; pfam13414
378806014202	binding surface
378806014203	TPR motif; other site
378806014204	TPR repeat; Region: TPR_11; pfam13414
378806014205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806014206	binding surface
378806014207	TPR motif; other site
378806014208	TPR repeat; Region: TPR_11; pfam13414
378806014209	TPR repeat; Region: TPR_11; pfam13414
378806014210	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
378806014211	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806014212	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806014213	catalytic residue [active]
378806014214	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
378806014215	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
378806014216	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
378806014217	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
378806014218	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
378806014219	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
378806014220	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
378806014221	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
378806014222	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
378806014223	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
378806014224	DNA binding site [nucleotide binding]
378806014225	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
378806014226	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
378806014227	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
378806014228	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
378806014229	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
378806014230	RPB11 interaction site [polypeptide binding]; other site
378806014231	RPB12 interaction site [polypeptide binding]; other site
378806014232	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
378806014233	RPB3 interaction site [polypeptide binding]; other site
378806014234	RPB1 interaction site [polypeptide binding]; other site
378806014235	RPB11 interaction site [polypeptide binding]; other site
378806014236	RPB10 interaction site [polypeptide binding]; other site
378806014237	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
378806014238	core dimer interface [polypeptide binding]; other site
378806014239	peripheral dimer interface [polypeptide binding]; other site
378806014240	L10 interface [polypeptide binding]; other site
378806014241	L11 interface [polypeptide binding]; other site
378806014242	putative EF-Tu interaction site [polypeptide binding]; other site
378806014243	putative EF-G interaction site [polypeptide binding]; other site
378806014244	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
378806014245	23S rRNA interface [nucleotide binding]; other site
378806014246	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
378806014247	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
378806014248	mRNA/rRNA interface [nucleotide binding]; other site
378806014249	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
378806014250	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
378806014251	23S rRNA interface [nucleotide binding]; other site
378806014252	L7/L12 interface [polypeptide binding]; other site
378806014253	putative thiostrepton binding site; other site
378806014254	L25 interface [polypeptide binding]; other site
378806014255	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
378806014256	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
378806014257	putative homodimer interface [polypeptide binding]; other site
378806014258	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
378806014259	heterodimer interface [polypeptide binding]; other site
378806014260	homodimer interface [polypeptide binding]; other site
378806014261	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
378806014262	elongation factor Tu; Reviewed; Region: PRK00049
378806014263	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
378806014264	G1 box; other site
378806014265	GEF interaction site [polypeptide binding]; other site
378806014266	GTP/Mg2+ binding site [chemical binding]; other site
378806014267	Switch I region; other site
378806014268	G2 box; other site
378806014269	G3 box; other site
378806014270	Switch II region; other site
378806014271	G4 box; other site
378806014272	G5 box; other site
378806014273	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
378806014274	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
378806014275	Antibiotic Binding Site [chemical binding]; other site
378806014276	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
378806014277	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
378806014278	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
378806014279	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
378806014280	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
378806014281	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806014282	von Willebrand factor type A domain; Region: VWA_2; pfam13519
378806014283	metal ion-dependent adhesion site (MIDAS); other site
378806014284	HEAT repeats; Region: HEAT_2; pfam13646
378806014285	HEAT repeat; Region: HEAT; pfam02985
378806014286	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
378806014287	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806014288	motif II; other site
378806014289	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
378806014290	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806014291	ATP binding site [chemical binding]; other site
378806014292	putative Mg++ binding site [ion binding]; other site
378806014293	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806014294	nucleotide binding region [chemical binding]; other site
378806014295	Helicase associated domain (HA2); Region: HA2; pfam04408
378806014296	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
378806014297	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
378806014298	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
378806014299	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806014300	Coenzyme A binding pocket [chemical binding]; other site
378806014301	MFS_1 like family; Region: MFS_1_like; pfam12832
378806014302	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806014303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806014304	Ferredoxin [Energy production and conversion]; Region: COG1146
378806014305	4Fe-4S binding domain; Region: Fer4; pfam00037
378806014306	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
378806014307	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
378806014308	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
378806014309	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
378806014310	active site residue [active]
378806014311	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
378806014312	Right handed beta helix region; Region: Beta_helix; pfam13229
378806014313	Stage II sporulation protein; Region: SpoIID; pfam08486
378806014314	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
378806014315	TonB C terminal; Region: TonB_2; pfam13103
378806014316	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
378806014317	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
378806014318	glycine dehydrogenase; Provisional; Region: PRK05367
378806014319	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
378806014320	tetramer interface [polypeptide binding]; other site
378806014321	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806014322	catalytic residue [active]
378806014323	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
378806014324	tetramer interface [polypeptide binding]; other site
378806014325	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806014326	catalytic residue [active]
378806014327	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
378806014328	lipoyl attachment site [posttranslational modification]; other site
378806014329	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
378806014330	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
378806014331	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
378806014332	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
378806014333	FAD binding site [chemical binding]; other site
378806014334	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
378806014335	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
378806014336	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
378806014337	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
378806014338	homodimer interface [polypeptide binding]; other site
378806014339	NADP binding site [chemical binding]; other site
378806014340	substrate binding site [chemical binding]; other site
378806014341	Protein of unknown function (DUF456); Region: DUF456; pfam04306
378806014342	Tellurite resistance protein TerB; Region: TerB; cl17311
378806014343	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806014344	HSP70 interaction site [polypeptide binding]; other site
378806014345	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
378806014346	Smr domain; Region: Smr; pfam01713
378806014347	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806014348	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
378806014349	active site
378806014350	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
378806014351	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
378806014352	quinone interaction residues [chemical binding]; other site
378806014353	active site
378806014354	catalytic residues [active]
378806014355	FMN binding site [chemical binding]; other site
378806014356	substrate binding site [chemical binding]; other site
378806014357	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
378806014358	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
378806014359	putative ADP-binding pocket [chemical binding]; other site
378806014360	O-Antigen ligase; Region: Wzy_C; cl04850
378806014361	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
378806014362	G1 box; other site
378806014363	GTP/Mg2+ binding site [chemical binding]; other site
378806014364	Switch I region; other site
378806014365	G2 box; other site
378806014366	G3 box; other site
378806014367	Switch II region; other site
378806014368	G4 box; other site
378806014369	G5 box; other site
378806014370	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
378806014371	dephospho-CoA kinase; Region: TIGR00152
378806014372	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
378806014373	CoA-binding site [chemical binding]; other site
378806014374	thioester reductase domain; Region: Thioester-redct; TIGR01746
378806014375	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
378806014376	putative NAD(P) binding site [chemical binding]; other site
378806014377	active site
378806014378	putative substrate binding site [chemical binding]; other site
378806014379	REJ domain; Region: REJ; pfam02010
378806014380	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
378806014381	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
378806014382	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
378806014383	PA/protease or protease-like domain interface [polypeptide binding]; other site
378806014384	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
378806014385	Zn binding site [ion binding]; other site
378806014386	REJ domain; Region: REJ; pfam02010
378806014387	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
378806014388	active site 2 [active]
378806014389	active site 1 [active]
378806014390	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
378806014391	active site
378806014392	catalytic site [active]
378806014393	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806014394	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806014395	active site
378806014396	catalytic tetrad [active]
378806014397	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
378806014398	Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848
378806014399	Starch binding domain; Region: CBM_2; smart01065
378806014400	starch-binding site 2 [chemical binding]; other site
378806014401	starch-binding site 1 [chemical binding]; other site
378806014402	Putative esterase; Region: Esterase; pfam00756
378806014403	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
378806014404	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806014405	HSP70 interaction site [polypeptide binding]; other site
378806014406	TPR repeat; Region: TPR_11; pfam13414
378806014407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806014408	binding surface
378806014409	TPR repeat; Region: TPR_11; pfam13414
378806014410	TPR motif; other site
378806014411	acetylornithine aminotransferase; Provisional; Region: PRK02627
378806014412	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806014413	inhibitor-cofactor binding pocket; inhibition site
378806014414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806014415	catalytic residue [active]
378806014416	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
378806014417	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806014418	Walker A motif; other site
378806014419	ATP binding site [chemical binding]; other site
378806014420	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
378806014421	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
378806014422	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
378806014423	active site
378806014424	HslU subunit interaction site [polypeptide binding]; other site
378806014425	SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381
378806014426	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
378806014427	Protein kinase domain; Region: Pkinase; pfam00069
378806014428	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806014429	active site
378806014430	ATP binding site [chemical binding]; other site
378806014431	substrate binding site [chemical binding]; other site
378806014432	activation loop (A-loop); other site
378806014433	Protein kinase domain; Region: Pkinase; pfam00069
378806014434	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806014435	active site
378806014436	ATP binding site [chemical binding]; other site
378806014437	substrate binding site [chemical binding]; other site
378806014438	activation loop (A-loop); other site
378806014439	AAA ATPase domain; Region: AAA_16; pfam13191
378806014440	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
378806014441	RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001
378806014442	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806014443	DNA binding residues [nucleotide binding]
378806014444	Beta-propeller repeat; Region: SBBP; pfam06739
378806014445	Beta-propeller repeat; Region: SBBP; pfam06739
378806014446	Beta-propeller repeat; Region: SBBP; pfam06739
378806014447	active site
378806014448	Patatin-like phospholipase; Region: Patatin; pfam01734
378806014449	nucleophile elbow; other site
378806014450	DDE superfamily endonuclease; Region: DDE_3; pfam13358
378806014451	Protein kinase domain; Region: Pkinase; pfam00069
378806014452	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806014453	active site
378806014454	ATP binding site [chemical binding]; other site
378806014455	substrate binding site [chemical binding]; other site
378806014456	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806014457	substrate binding site [chemical binding]; other site
378806014458	activation loop (A-loop); other site
378806014459	activation loop (A-loop); other site
378806014460	AAA ATPase domain; Region: AAA_16; pfam13191
378806014461	Predicted ATPase [General function prediction only]; Region: COG3899
378806014462	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806014463	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806014464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806014465	ATP binding site [chemical binding]; other site
378806014466	Mg2+ binding site [ion binding]; other site
378806014467	G-X-G motif; other site
378806014468	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
378806014469	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806014470	active site
378806014471	DNA binding site [nucleotide binding]
378806014472	Int/Topo IB signature motif; other site
378806014473	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
378806014474	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
378806014475	Glucose inhibited division protein A; Region: GIDA; pfam01134
378806014476	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
378806014477	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
378806014478	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
378806014479	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
378806014480	DNA topoisomerase I; Validated; Region: PRK06599
378806014481	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
378806014482	active site
378806014483	interdomain interaction site; other site
378806014484	putative metal-binding site [ion binding]; other site
378806014485	nucleotide binding site [chemical binding]; other site
378806014486	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
378806014487	domain I; other site
378806014488	DNA binding groove [nucleotide binding]
378806014489	phosphate binding site [ion binding]; other site
378806014490	domain II; other site
378806014491	domain III; other site
378806014492	nucleotide binding site [chemical binding]; other site
378806014493	catalytic site [active]
378806014494	domain IV; other site
378806014495	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
378806014496	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
378806014497	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
378806014498	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
378806014499	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
378806014500	DNA protecting protein DprA; Region: dprA; TIGR00732
378806014501	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
378806014502	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806014503	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
378806014504	Tetratricopeptide repeat; Region: TPR_6; pfam13174
378806014505	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
378806014506	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
378806014507	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806014508	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806014509	dimerization interface [polypeptide binding]; other site
378806014510	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806014511	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806014512	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806014513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806014514	metal binding site [ion binding]; metal-binding site
378806014515	active site
378806014516	I-site; other site
378806014517	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
378806014518	oxyanion hole [active]
378806014519	active site
378806014520	catalytic triad [active]
378806014521	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
378806014522	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806014523	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806014524	protein binding site [polypeptide binding]; other site
378806014525	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806014526	protein binding site [polypeptide binding]; other site
378806014527	Uncharacterized conserved protein [Function unknown]; Region: COG1543
378806014528	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
378806014529	active site
378806014530	substrate binding site [chemical binding]; other site
378806014531	catalytic site [active]
378806014532	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
378806014533	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
378806014534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
378806014535	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806014536	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806014537	Response regulator receiver domain; Region: Response_reg; pfam00072
378806014538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806014539	active site
378806014540	phosphorylation site [posttranslational modification]
378806014541	intermolecular recognition site; other site
378806014542	dimerization interface [polypeptide binding]; other site
378806014543	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806014544	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806014545	Walker A motif; other site
378806014546	ATP binding site [chemical binding]; other site
378806014547	Walker B motif; other site
378806014548	arginine finger; other site
378806014549	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
378806014550	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
378806014551	homodimer interface [polypeptide binding]; other site
378806014552	substrate-cofactor binding pocket; other site
378806014553	catalytic residue [active]
378806014554	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806014555	Walker A motif; other site
378806014556	ATP binding site [chemical binding]; other site
378806014557	Fic/DOC family; Region: Fic; pfam02661
378806014558	endonuclease IV; Provisional; Region: PRK01060
378806014559	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
378806014560	AP (apurinic/apyrimidinic) site pocket; other site
378806014561	DNA interaction; other site
378806014562	Metal-binding active site; metal-binding site
378806014563	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
378806014564	DHH family; Region: DHH; pfam01368
378806014565	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
378806014566	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
378806014567	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806014568	catalytic residue [active]
378806014569	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806014570	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806014571	active site
378806014572	ATP binding site [chemical binding]; other site
378806014573	substrate binding site [chemical binding]; other site
378806014574	activation loop (A-loop); other site
378806014575	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806014576	binding surface
378806014577	TPR motif; other site
378806014578	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
378806014579	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
378806014580	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
378806014581	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
378806014582	active site
378806014583	HIGH motif; other site
378806014584	dimer interface [polypeptide binding]; other site
378806014585	KMSKS motif; other site
378806014586	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806014587	RNA binding surface [nucleotide binding]; other site
378806014588	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
378806014589	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806014590	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806014591	structural tetrad; other site
378806014592	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
378806014593	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
378806014594	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
378806014595	6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205
378806014596	active site
378806014597	ADP/pyrophosphate binding site [chemical binding]; other site
378806014598	dimerization interface [polypeptide binding]; other site
378806014599	allosteric effector site; other site
378806014600	fructose-1,6-bisphosphate binding site; other site
378806014601	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806014602	putative DNA binding site [nucleotide binding]; other site
378806014603	putative Zn2+ binding site [ion binding]; other site
378806014604	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
378806014605	active site triad [active]
378806014606	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806014607	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806014608	active site
378806014609	acyl-CoA synthetase; Validated; Region: PRK09192
378806014610	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806014611	acyl-activating enzyme (AAE) consensus motif; other site
378806014612	active site
378806014613	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
378806014614	active site
378806014615	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
378806014616	dinuclear metal binding motif [ion binding]; other site
378806014617	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
378806014618	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
378806014619	CoA-transferase family III; Region: CoA_transf_3; pfam02515
378806014620	SCP-2 sterol transfer family; Region: SCP2; pfam02036
378806014621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806014622	Response regulator receiver domain; Region: Response_reg; pfam00072
378806014623	active site
378806014624	phosphorylation site [posttranslational modification]
378806014625	intermolecular recognition site; other site
378806014626	dimerization interface [polypeptide binding]; other site
378806014627	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806014628	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
378806014629	dimer interface [polypeptide binding]; other site
378806014630	phosphorylation site [posttranslational modification]
378806014631	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
378806014632	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
378806014633	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806014634	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
378806014635	putative AMP binding site [chemical binding]; other site
378806014636	putative active site [active]
378806014637	acyl-activating enzyme (AAE) consensus motif; other site
378806014638	putative CoA binding site [chemical binding]; other site
378806014639	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
378806014640	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
378806014641	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806014642	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
378806014643	FAD binding domain; Region: FAD_binding_4; pfam01565
378806014644	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
378806014645	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
378806014646	active site
378806014647	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
378806014648	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
378806014649	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
378806014650	intersubunit interface [polypeptide binding]; other site
378806014651	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
378806014652	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
378806014653	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
378806014654	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
378806014655	putative PBP binding regions; other site
378806014656	ABC-ATPase subunit  interface; other site
378806014657	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
378806014658	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
378806014659	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
378806014660	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
378806014661	putative catalytic residue [active]
378806014662	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
378806014663	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
378806014664	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
378806014665	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
378806014666	dimer interface [polypeptide binding]; other site
378806014667	[2Fe-2S] cluster binding site [ion binding]; other site
378806014668	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
378806014669	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
378806014670	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
378806014671	active site
378806014672	dimer interface [polypeptide binding]; other site
378806014673	effector binding site; other site
378806014674	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
378806014675	TSCPD domain; Region: TSCPD; pfam12637
378806014676	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806014677	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
378806014678	CoA binding domain; Region: CoA_binding; cl17356
378806014679	Bacterial sugar transferase; Region: Bac_transf; pfam02397
378806014680	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806014681	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
378806014682	putative ADP-binding pocket [chemical binding]; other site
378806014683	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
378806014684	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806014685	O-Antigen ligase; Region: Wzy_C; pfam04932
378806014686	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
378806014687	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
378806014688	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
378806014689	Predicted permeases [General function prediction only]; Region: COG0795
378806014690	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
378806014691	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
378806014692	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
378806014693	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
378806014694	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
378806014695	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
378806014696	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806014697	TPR motif; other site
378806014698	binding surface
378806014699	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
378806014700	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
378806014701	purine monophosphate binding site [chemical binding]; other site
378806014702	dimer interface [polypeptide binding]; other site
378806014703	putative catalytic residues [active]
378806014704	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
378806014705	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
378806014706	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806014707	DNA binding residues [nucleotide binding]
378806014708	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
378806014709	DNA binding residues [nucleotide binding]
378806014710	Protein kinase domain; Region: Pkinase; pfam00069
378806014711	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806014712	active site
378806014713	ATP binding site [chemical binding]; other site
378806014714	substrate binding site [chemical binding]; other site
378806014715	activation loop (A-loop); other site
378806014716	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806014717	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806014718	active site
378806014719	ATP binding site [chemical binding]; other site
378806014720	substrate binding site [chemical binding]; other site
378806014721	activation loop (A-loop); other site
378806014722	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
378806014723	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
378806014724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806014725	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806014726	putative active site [active]
378806014727	heme pocket [chemical binding]; other site
378806014728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806014729	dimer interface [polypeptide binding]; other site
378806014730	phosphorylation site [posttranslational modification]
378806014731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806014732	ATP binding site [chemical binding]; other site
378806014733	Mg2+ binding site [ion binding]; other site
378806014734	G-X-G motif; other site
378806014735	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
378806014736	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
378806014737	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
378806014738	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806014739	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806014740	active site
378806014741	ATP binding site [chemical binding]; other site
378806014742	substrate binding site [chemical binding]; other site
378806014743	activation loop (A-loop); other site
378806014744	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
378806014745	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
378806014746	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
378806014747	active site
378806014748	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
378806014749	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
378806014750	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
378806014751	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
378806014752	DNA binding site [nucleotide binding]
378806014753	active site
378806014754	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
378806014755	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
378806014756	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
378806014757	FAD binding domain; Region: FAD_binding_4; pfam01565
378806014758	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806014759	Zn binding site [ion binding]; other site
378806014760	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
378806014761	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
378806014762	Predicted acyl esterases [General function prediction only]; Region: COG2936
378806014763	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
378806014764	PAS domain S-box; Region: sensory_box; TIGR00229
378806014765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806014766	ATP binding site [chemical binding]; other site
378806014767	Mg2+ binding site [ion binding]; other site
378806014768	G-X-G motif; other site
378806014769	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806014770	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
378806014771	active site
378806014772	acyl-CoA synthetase; Validated; Region: PRK05850
378806014773	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806014774	acyl-activating enzyme (AAE) consensus motif; other site
378806014775	active site
378806014776	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
378806014777	putative hydrophobic ligand binding site [chemical binding]; other site
378806014778	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806014779	Cytochrome P450; Region: p450; cl12078
378806014780	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806014781	Cytochrome P450; Region: p450; cl12078
378806014782	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806014783	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806014784	active site
378806014785	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806014786	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806014787	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806014788	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806014789	putative NADP binding site [chemical binding]; other site
378806014790	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806014791	active site
378806014792	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014793	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806014794	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806014795	active site
378806014796	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806014797	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806014798	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806014799	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806014800	KR domain; Region: KR; pfam08659
378806014801	putative NADP binding site [chemical binding]; other site
378806014802	active site
378806014803	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014804	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806014805	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806014806	active site
378806014807	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806014808	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806014809	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806014810	putative NADP binding site [chemical binding]; other site
378806014811	KR domain; Region: KR; pfam08659
378806014812	active site
378806014813	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014814	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806014815	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806014816	active site
378806014817	Acyl transferase domain; Region: Acyl_transf_1; cl08282
378806014818	Acyl transferase domain; Region: Acyl_transf_1; cl08282
378806014819	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806014820	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
378806014821	Enoylreductase; Region: PKS_ER; smart00829
378806014822	NAD(P) binding site [chemical binding]; other site
378806014823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806014824	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806014825	NAD(P) binding site [chemical binding]; other site
378806014826	active site
378806014827	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014828	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806014829	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806014830	active site
378806014831	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806014832	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806014833	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806014834	KR domain; Region: KR; pfam08659
378806014835	putative NADP binding site [chemical binding]; other site
378806014836	active site
378806014837	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014838	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806014839	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806014840	active site
378806014841	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806014842	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806014843	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
378806014844	NADP binding site [chemical binding]; other site
378806014845	active site
378806014846	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014847	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806014848	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806014849	active site
378806014850	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806014851	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806014852	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806014853	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
378806014854	Enoylreductase; Region: PKS_ER; smart00829
378806014855	NAD(P) binding site [chemical binding]; other site
378806014856	KR domain; Region: KR; pfam08659
378806014857	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806014858	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014859	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806014860	Cytochrome P450; Region: p450; cl12078
378806014861	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014862	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806014863	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
378806014864	active site
378806014865	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806014866	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806014867	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806014868	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806014869	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806014870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806014871	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
378806014872	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
378806014873	NAD(P) binding site [chemical binding]; other site
378806014874	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806014875	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
378806014876	putative NADP binding site [chemical binding]; other site
378806014877	active site
378806014878	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806014879	hypothetical protein; Provisional; Region: PRK06184
378806014880	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806014881	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806014882	Right handed beta helix region; Region: Beta_helix; pfam13229
378806014883	Integrase core domain; Region: rve; pfam00665
378806014884	DDE domain; Region: DDE_Tnp_IS240; pfam13610
378806014885	Integrase core domain; Region: rve_3; pfam13683
378806014886	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
378806014887	RibD C-terminal domain; Region: RibD_C; cl17279
378806014888	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806014889	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806014890	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
378806014891	Int/Topo IB signature motif; other site
378806014892	DNA binding site [nucleotide binding]
378806014893	Preprotein translocase SecG subunit; Region: SecG; pfam03840
378806014894	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
378806014895	triosephosphate isomerase; Provisional; Region: PRK14565
378806014896	substrate binding site [chemical binding]; other site
378806014897	dimer interface [polypeptide binding]; other site
378806014898	catalytic triad [active]
378806014899	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
378806014900	Phosphoglycerate kinase; Region: PGK; pfam00162
378806014901	substrate binding site [chemical binding]; other site
378806014902	hinge regions; other site
378806014903	ADP binding site [chemical binding]; other site
378806014904	catalytic site [active]
378806014905	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
378806014906	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
378806014907	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
378806014908	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
378806014909	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
378806014910	active site
378806014911	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806014912	Interdomain contacts; other site
378806014913	Cytokine receptor motif; other site
378806014914	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
378806014915	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
378806014916	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
378806014917	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
378806014918	putative RNA binding site [nucleotide binding]; other site
378806014919	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806014920	S-adenosylmethionine binding site [chemical binding]; other site
378806014921	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
378806014922	generic binding surface II; other site
378806014923	generic binding surface I; other site
378806014924	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
378806014925	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806014926	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806014927	Zn2+ binding site [ion binding]; other site
378806014928	Mg2+ binding site [ion binding]; other site
378806014929	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806014930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
378806014931	active site
378806014932	phosphorylation site [posttranslational modification]
378806014933	intermolecular recognition site; other site
378806014934	dimerization interface [polypeptide binding]; other site
378806014935	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806014936	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
378806014937	active site
378806014938	HEAT repeats; Region: HEAT_2; pfam13646
378806014939	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
378806014940	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
378806014941	active site
378806014942	HIGH motif; other site
378806014943	KMSKS motif; other site
378806014944	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
378806014945	anticodon binding site; other site
378806014946	tRNA binding surface [nucleotide binding]; other site
378806014947	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
378806014948	dimer interface [polypeptide binding]; other site
378806014949	putative tRNA-binding site [nucleotide binding]; other site
378806014950	NRDE protein; Region: NRDE; cl01315
378806014951	Response regulator receiver domain; Region: Response_reg; pfam00072
378806014952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806014953	active site
378806014954	phosphorylation site [posttranslational modification]
378806014955	intermolecular recognition site; other site
378806014956	dimerization interface [polypeptide binding]; other site
378806014957	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
378806014958	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
378806014959	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
378806014960	DNA polymerase III subunit delta'; Validated; Region: PRK08485
378806014961	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
378806014962	Mechanosensitive ion channel; Region: MS_channel; pfam00924
378806014963	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806014964	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806014965	ligand binding site [chemical binding]; other site
378806014966	flexible hinge region; other site
378806014967	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806014968	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
378806014969	active site
378806014970	metal binding site [ion binding]; metal-binding site
378806014971	Response regulator receiver domain; Region: Response_reg; pfam00072
378806014972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806014973	active site
378806014974	phosphorylation site [posttranslational modification]
378806014975	intermolecular recognition site; other site
378806014976	dimerization interface [polypeptide binding]; other site
378806014977	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806014978	ATP binding site [chemical binding]; other site
378806014979	Mg2+ binding site [ion binding]; other site
378806014980	G-X-G motif; other site
378806014981	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
378806014982	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806014983	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
378806014984	hydroxyglutarate oxidase; Provisional; Region: PRK11728
378806014985	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806014986	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
378806014987	putative C-terminal domain interface [polypeptide binding]; other site
378806014988	putative GSH binding site (G-site) [chemical binding]; other site
378806014989	putative dimer interface [polypeptide binding]; other site
378806014990	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
378806014991	putative N-terminal domain interface [polypeptide binding]; other site
378806014992	putative dimer interface [polypeptide binding]; other site
378806014993	putative substrate binding pocket (H-site) [chemical binding]; other site
378806014994	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
378806014995	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
378806014996	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
378806014997	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806014998	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806014999	active site
378806015000	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
378806015001	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806015002	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806015003	acyl-activating enzyme (AAE) consensus motif; other site
378806015004	acyl-activating enzyme (AAE) consensus motif; other site
378806015005	AMP binding site [chemical binding]; other site
378806015006	active site
378806015007	CoA binding site [chemical binding]; other site
378806015008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806015009	putative substrate translocation pore; other site
378806015010	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806015011	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
378806015012	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806015013	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806015014	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
378806015015	putative effector binding pocket; other site
378806015016	dimerization interface [polypeptide binding]; other site
378806015017	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
378806015018	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806015019	NAD(P) binding site [chemical binding]; other site
378806015020	active site
378806015021	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
378806015022	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
378806015023	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806015024	FtsX-like permease family; Region: FtsX; pfam02687
378806015025	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806015026	FtsX-like permease family; Region: FtsX; pfam02687
378806015027	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
378806015028	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
378806015029	Walker A/P-loop; other site
378806015030	ATP binding site [chemical binding]; other site
378806015031	Q-loop/lid; other site
378806015032	ABC transporter signature motif; other site
378806015033	Walker B; other site
378806015034	D-loop; other site
378806015035	H-loop/switch region; other site
378806015036	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
378806015037	MarR family; Region: MarR; pfam01047
378806015038	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
378806015039	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
378806015040	ATP binding site [chemical binding]; other site
378806015041	Mg++ binding site [ion binding]; other site
378806015042	motif III; other site
378806015043	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806015044	nucleotide binding region [chemical binding]; other site
378806015045	ATP-binding site [chemical binding]; other site
378806015046	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
378806015047	putative RNA binding site [nucleotide binding]; other site
378806015048	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
378806015049	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
378806015050	active site
378806015051	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
378806015052	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
378806015053	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806015054	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
378806015055	Enoylreductase; Region: PKS_ER; smart00829
378806015056	NAD(P) binding site [chemical binding]; other site
378806015057	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
378806015058	KR domain; Region: KR; pfam08659
378806015059	putative NADP binding site [chemical binding]; other site
378806015060	active site
378806015061	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
378806015062	Thioesterase domain; Region: Thioesterase; pfam00975
378806015063	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
378806015064	active site
378806015065	catalytic residues [active]
378806015066	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
378806015067	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
378806015068	metal binding site [ion binding]; metal-binding site
378806015069	ligand binding site [chemical binding]; other site
378806015070	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
378806015071	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
378806015072	dimer interface [polypeptide binding]; other site
378806015073	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806015074	catalytic residue [active]
378806015075	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806015076	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
378806015077	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806015078	active site
378806015079	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
378806015080	heme binding pocket [chemical binding]; other site
378806015081	GAF domain; Region: GAF; pfam01590
378806015082	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806015083	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806015084	DNA binding residues [nucleotide binding]
378806015085	dimerization interface [polypeptide binding]; other site
378806015086	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
378806015087	catalytic core [active]
378806015088	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
378806015089	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806015090	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
378806015091	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
378806015092	Ca2+ binding site [ion binding]; other site
378806015093	EF-hand domain pair; Region: EF_hand_6; pfam13833
378806015094	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806015095	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806015096	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
378806015097	active site
378806015098	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
378806015099	homodimer interface [polypeptide binding]; other site
378806015100	homotetramer interface [polypeptide binding]; other site
378806015101	active site pocket [active]
378806015102	cleavage site
378806015103	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
378806015104	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
378806015105	Predicted membrane protein [Function unknown]; Region: COG2119
378806015106	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
378806015107	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
378806015108	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806015109	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
378806015110	PA/protease or protease-like domain interface [polypeptide binding]; other site
378806015111	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
378806015112	Zn binding site [ion binding]; other site
378806015113	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
378806015114	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
378806015115	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
378806015116	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
378806015117	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
378806015118	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806015119	dimer interface [polypeptide binding]; other site
378806015120	conserved gate region; other site
378806015121	putative PBP binding loops; other site
378806015122	ABC-ATPase subunit interface; other site
378806015123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
378806015124	AAA domain; Region: AAA_11; pfam13086
378806015125	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806015126	ATP binding site [chemical binding]; other site
378806015127	AAA domain; Region: AAA_12; pfam13087
378806015128	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
378806015129	Family description; Region: UvrD_C_2; pfam13538
378806015130	Lysyl oxidase; Region: Lysyl_oxidase; pfam01186
378806015131	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806015132	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806015133	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806015134	substrate binding site [chemical binding]; other site
378806015135	activation loop (A-loop); other site
378806015136	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806015137	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
378806015138	active site
378806015139	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
378806015140	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
378806015141	dimer interface [polypeptide binding]; other site
378806015142	active site
378806015143	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
378806015144	dimer interface [polypeptide binding]; other site
378806015145	active site
378806015146	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
378806015147	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806015148	DNA-binding site [nucleotide binding]; DNA binding site
378806015149	UTRA domain; Region: UTRA; pfam07702
378806015150	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
378806015151	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
378806015152	putative active site [active]
378806015153	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
378806015154	HPr interaction site; other site
378806015155	glycerol kinase (GK) interaction site [polypeptide binding]; other site
378806015156	active site
378806015157	phosphorylation site [posttranslational modification]
378806015158	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
378806015159	dimerization domain swap beta strand [polypeptide binding]; other site
378806015160	regulatory protein interface [polypeptide binding]; other site
378806015161	active site
378806015162	regulatory phosphorylation site [posttranslational modification]; other site
378806015163	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
378806015164	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
378806015165	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
378806015166	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
378806015167	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
378806015168	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
378806015169	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
378806015170	active site turn [active]
378806015171	phosphorylation site [posttranslational modification]
378806015172	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
378806015173	active site turn [active]
378806015174	phosphorylation site [posttranslational modification]
378806015175	Putative carbohydrate binding domain; Region: CHB_HEX; cl03918
378806015176	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
378806015177	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569
378806015178	active site
378806015179	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
378806015180	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806015181	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806015182	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806015183	DNA binding residues [nucleotide binding]
378806015184	Cellulose binding domain; Region: CBM_2; pfam00553
378806015185	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cd00598
378806015186	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
378806015187	active site
378806015188	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
378806015189	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806015190	Interdomain contacts; other site
378806015191	Cytokine receptor motif; other site
378806015192	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806015193	Interdomain contacts; other site
378806015194	Cytokine receptor motif; other site
378806015195	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
378806015196	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
378806015197	putative active site [active]
378806015198	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
378806015199	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806015200	Interdomain contacts; other site
378806015201	putative alpha-glucosidase; Provisional; Region: PRK10658
378806015202	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
378806015203	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
378806015204	trimer interface [polypeptide binding]; other site
378806015205	active site
378806015206	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
378806015207	catalytic site [active]
378806015208	thiamine pyrophosphate protein; Provisional; Region: PRK08273
378806015209	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
378806015210	PYR/PP interface [polypeptide binding]; other site
378806015211	dimer interface [polypeptide binding]; other site
378806015212	tetramer interface [polypeptide binding]; other site
378806015213	TPP binding site [chemical binding]; other site
378806015214	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
378806015215	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
378806015216	TPP-binding site [chemical binding]; other site
378806015217	TonB C terminal; Region: TonB_2; pfam13103
378806015218	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806015219	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806015220	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806015221	Cytochrome P450; Region: p450; cl12078
378806015222	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
378806015223	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
378806015224	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
378806015225	putative active site [active]
378806015226	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806015227	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806015228	phosphopeptide binding site; other site
378806015229	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806015230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806015231	Walker A motif; other site
378806015232	ATP binding site [chemical binding]; other site
378806015233	Walker B motif; other site
378806015234	arginine finger; other site
378806015235	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
378806015236	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806015237	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806015238	active site
378806015239	ATP binding site [chemical binding]; other site
378806015240	substrate binding site [chemical binding]; other site
378806015241	activation loop (A-loop); other site
378806015242	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806015243	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015244	binding surface
378806015245	TPR motif; other site
378806015246	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806015247	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806015248	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
378806015249	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806015250	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806015251	catalytic residue [active]
378806015252	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
378806015253	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
378806015254	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806015255	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806015256	active site
378806015257	catalytic tetrad [active]
378806015258	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806015259	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806015260	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
378806015261	ArsC family; Region: ArsC; pfam03960
378806015262	putative ArsC-like catalytic residues; other site
378806015263	putative TRX-like catalytic residues [active]
378806015264	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
378806015265	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806015266	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806015267	catalytic residue [active]
378806015268	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806015269	active site
378806015270	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
378806015271	nudix motif; other site
378806015272	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
378806015273	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
378806015274	dimer interface [polypeptide binding]; other site
378806015275	active site
378806015276	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
378806015277	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806015278	ATP binding site [chemical binding]; other site
378806015279	putative Mg++ binding site [ion binding]; other site
378806015280	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806015281	nucleotide binding region [chemical binding]; other site
378806015282	ATP-binding site [chemical binding]; other site
378806015283	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
378806015284	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
378806015285	dimer interface [polypeptide binding]; other site
378806015286	NAD binding site [chemical binding]; other site
378806015287	substrate binding site [chemical binding]; other site
378806015288	tetramer (dimer of dimers) interface [polypeptide binding]; other site
378806015289	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806015290	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806015291	WHG domain; Region: WHG; pfam13305
378806015292	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806015293	atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229
378806015294	putative NAD(P) binding site [chemical binding]; other site
378806015295	putative active site [active]
378806015296	LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235
378806015297	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806015298	active site
378806015299	motif I; other site
378806015300	motif II; other site
378806015301	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
378806015302	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806015303	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
378806015304	dimerization interface [polypeptide binding]; other site
378806015305	acetolactate synthase; Reviewed; Region: PRK08322
378806015306	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
378806015307	PYR/PP interface [polypeptide binding]; other site
378806015308	dimer interface [polypeptide binding]; other site
378806015309	TPP binding site [chemical binding]; other site
378806015310	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
378806015311	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
378806015312	TPP-binding site [chemical binding]; other site
378806015313	dimer interface [polypeptide binding]; other site
378806015314	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
378806015315	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
378806015316	NAD(P) binding site [chemical binding]; other site
378806015317	catalytic residues [active]
378806015318	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
378806015319	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
378806015320	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806015321	short chain dehydrogenase; Provisional; Region: PRK06180
378806015322	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
378806015323	NADP binding site [chemical binding]; other site
378806015324	active site
378806015325	steroid binding site; other site
378806015326	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
378806015327	putative hydrophobic ligand binding site [chemical binding]; other site
378806015328	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806015329	dimerization interface [polypeptide binding]; other site
378806015330	putative DNA binding site [nucleotide binding]; other site
378806015331	putative Zn2+ binding site [ion binding]; other site
378806015332	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
378806015333	Domain interface; other site
378806015334	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
378806015335	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
378806015336	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806015337	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
378806015338	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
378806015339	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
378806015340	TPR repeat; Region: TPR_11; pfam13414
378806015341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015342	TPR motif; other site
378806015343	binding surface
378806015344	Bacterial SH3 domain; Region: SH3_3; pfam08239
378806015345	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806015346	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806015347	active site
378806015348	ATP binding site [chemical binding]; other site
378806015349	substrate binding site [chemical binding]; other site
378806015350	activation loop (A-loop); other site
378806015351	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806015352	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806015353	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806015354	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806015355	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806015356	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806015357	SEC-C motif; Region: SEC-C; pfam02810
378806015358	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806015359	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
378806015360	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
378806015361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
378806015362	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
378806015363	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
378806015364	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
378806015365	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
378806015366	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
378806015367	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
378806015368	beta-galactosidase; Region: BGL; TIGR03356
378806015369	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
378806015370	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
378806015371	Walker A/P-loop; other site
378806015372	ATP binding site [chemical binding]; other site
378806015373	Q-loop/lid; other site
378806015374	ABC transporter signature motif; other site
378806015375	Walker B; other site
378806015376	D-loop; other site
378806015377	H-loop/switch region; other site
378806015378	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
378806015379	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
378806015380	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
378806015381	Walker A/P-loop; other site
378806015382	ATP binding site [chemical binding]; other site
378806015383	Q-loop/lid; other site
378806015384	ABC transporter signature motif; other site
378806015385	Walker B; other site
378806015386	D-loop; other site
378806015387	H-loop/switch region; other site
378806015388	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
378806015389	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
378806015390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806015391	dimer interface [polypeptide binding]; other site
378806015392	conserved gate region; other site
378806015393	putative PBP binding loops; other site
378806015394	ABC-ATPase subunit interface; other site
378806015395	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
378806015396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806015397	dimer interface [polypeptide binding]; other site
378806015398	conserved gate region; other site
378806015399	putative PBP binding loops; other site
378806015400	ABC-ATPase subunit interface; other site
378806015401	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
378806015402	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
378806015403	substrate binding site [chemical binding]; other site
378806015404	SIR2-like domain; Region: SIR2_2; pfam13289
378806015405	CHAT domain; Region: CHAT; cl17868
378806015406	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806015407	TAP-like protein; Region: Abhydrolase_4; pfam08386
378806015408	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
378806015409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806015410	putative substrate translocation pore; other site
378806015411	Major Facilitator Superfamily; Region: MFS_1; pfam07690
378806015412	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
378806015413	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806015414	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806015415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806015416	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806015417	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806015418	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806015419	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
378806015420	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
378806015421	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806015422	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806015423	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806015424	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806015425	DNA binding site [nucleotide binding]
378806015426	active site
378806015427	Int/Topo IB signature motif; other site
378806015428	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
378806015429	TPR repeat; Region: TPR_11; pfam13414
378806015430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015431	TPR motif; other site
378806015432	binding surface
378806015433	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806015434	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
378806015435	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
378806015436	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
378806015437	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806015438	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806015439	catalytic residue [active]
378806015440	L-aspartate oxidase; Provisional; Region: PRK09077
378806015441	L-aspartate oxidase; Provisional; Region: PRK06175
378806015442	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
378806015443	Rhomboid family; Region: Rhomboid; pfam01694
378806015444	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
378806015445	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
378806015446	active site
378806015447	ParB-like nuclease domain; Region: ParBc; pfam02195
378806015448	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
378806015449	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
378806015450	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
378806015451	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
378806015452	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
378806015453	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
378806015454	TPR repeat; Region: TPR_11; pfam13414
378806015455	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015456	TPR motif; other site
378806015457	binding surface
378806015458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015459	binding surface
378806015460	TPR motif; other site
378806015461	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015462	TPR repeat; Region: TPR_11; pfam13414
378806015463	binding surface
378806015464	TPR motif; other site
378806015465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015466	binding surface
378806015467	TPR motif; other site
378806015468	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806015469	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015470	binding surface
378806015471	TPR motif; other site
378806015472	TPR repeat; Region: TPR_11; pfam13414
378806015473	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806015474	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806015475	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806015476	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
378806015477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806015478	ATP binding site [chemical binding]; other site
378806015479	Mg2+ binding site [ion binding]; other site
378806015480	G-X-G motif; other site
378806015481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806015482	active site
378806015483	phosphorylation site [posttranslational modification]
378806015484	intermolecular recognition site; other site
378806015485	dimerization interface [polypeptide binding]; other site
378806015486	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806015487	metal binding site [ion binding]; metal-binding site
378806015488	active site
378806015489	I-site; other site
378806015490	Cna protein B-type domain; Region: Cna_B_2; pfam13715
378806015491	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806015492	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806015493	ligand binding site [chemical binding]; other site
378806015494	MMPL family; Region: MMPL; pfam03176
378806015495	MMPL family; Region: MMPL; pfam03176
378806015496	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
378806015497	2,3-oxidosqualene cyclase; Region: osq_cycl; TIGR03463
378806015498	Active site cavity [active]
378806015499	catalytic acid [active]
378806015500	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
378806015501	active site lid residues [active]
378806015502	substrate binding pocket [chemical binding]; other site
378806015503	catalytic residues [active]
378806015504	substrate-Mg2+ binding site; other site
378806015505	aspartate-rich region 1; other site
378806015506	aspartate-rich region 2; other site
378806015507	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
378806015508	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806015509	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806015510	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
378806015511	TM-ABC transporter signature motif; other site
378806015512	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
378806015513	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
378806015514	Walker A/P-loop; other site
378806015515	ATP binding site [chemical binding]; other site
378806015516	Q-loop/lid; other site
378806015517	ABC transporter signature motif; other site
378806015518	Walker B; other site
378806015519	D-loop; other site
378806015520	H-loop/switch region; other site
378806015521	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
378806015522	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
378806015523	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
378806015524	ligand binding site [chemical binding]; other site
378806015525	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
378806015526	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806015527	RNA binding surface [nucleotide binding]; other site
378806015528	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
378806015529	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
378806015530	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
378806015531	TPP-binding site; other site
378806015532	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
378806015533	PYR/PP interface [polypeptide binding]; other site
378806015534	dimer interface [polypeptide binding]; other site
378806015535	TPP binding site [chemical binding]; other site
378806015536	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
378806015537	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
378806015538	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
378806015539	substrate binding pocket [chemical binding]; other site
378806015540	chain length determination region; other site
378806015541	substrate-Mg2+ binding site; other site
378806015542	catalytic residues [active]
378806015543	aspartate-rich region 1; other site
378806015544	active site lid residues [active]
378806015545	aspartate-rich region 2; other site
378806015546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806015547	Response regulator receiver domain; Region: Response_reg; pfam00072
378806015548	active site
378806015549	phosphorylation site [posttranslational modification]
378806015550	intermolecular recognition site; other site
378806015551	dimerization interface [polypeptide binding]; other site
378806015552	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
378806015553	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
378806015554	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
378806015555	generic binding surface II; other site
378806015556	generic binding surface I; other site
378806015557	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806015558	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806015559	phosphopeptide binding site; other site
378806015560	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806015561	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
378806015562	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
378806015563	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
378806015564	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
378806015565	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
378806015566	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
378806015567	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
378806015568	TadE-like protein; Region: TadE; pfam07811
378806015569	TadE-like protein; Region: TadE; pfam07811
378806015570	Putative zinc-finger; Region: zf-HC2; pfam13490
378806015571	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
378806015572	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806015573	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806015574	DNA binding residues [nucleotide binding]
378806015575	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
378806015576	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
378806015577	Walker A/P-loop; other site
378806015578	ATP binding site [chemical binding]; other site
378806015579	Q-loop/lid; other site
378806015580	ABC transporter signature motif; other site
378806015581	Walker B; other site
378806015582	D-loop; other site
378806015583	H-loop/switch region; other site
378806015584	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
378806015585	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
378806015586	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
378806015587	Walker A/P-loop; other site
378806015588	ATP binding site [chemical binding]; other site
378806015589	Q-loop/lid; other site
378806015590	ABC transporter signature motif; other site
378806015591	Walker B; other site
378806015592	D-loop; other site
378806015593	H-loop/switch region; other site
378806015594	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
378806015595	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806015596	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806015597	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
378806015598	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
378806015599	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
378806015600	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
378806015601	MgtE intracellular N domain; Region: MgtE_N; pfam03448
378806015602	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
378806015603	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
378806015604	Divalent cation transporter; Region: MgtE; pfam01769
378806015605	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
378806015606	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806015607	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806015608	dimer interface [polypeptide binding]; other site
378806015609	phosphorylation site [posttranslational modification]
378806015610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806015611	ATP binding site [chemical binding]; other site
378806015612	Mg2+ binding site [ion binding]; other site
378806015613	G-X-G motif; other site
378806015614	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806015615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806015616	active site
378806015617	phosphorylation site [posttranslational modification]
378806015618	intermolecular recognition site; other site
378806015619	dimerization interface [polypeptide binding]; other site
378806015620	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806015621	Walker A motif; other site
378806015622	ATP binding site [chemical binding]; other site
378806015623	Walker B motif; other site
378806015624	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806015625	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
378806015626	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806015627	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806015628	transcriptional activator TtdR; Provisional; Region: PRK09801
378806015629	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
378806015630	putative effector binding pocket; other site
378806015631	dimerization interface [polypeptide binding]; other site
378806015632	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
378806015633	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
378806015634	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
378806015635	Biofilm formation and stress response factor; Region: BsmA; pfam10014
378806015636	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
378806015637	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806015638	active site
378806015639	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
378806015640	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
378806015641	active site
378806015642	catalytic site [active]
378806015643	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
378806015644	active site
378806015645	catalytic site [active]
378806015646	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
378806015647	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
378806015648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806015649	active site
378806015650	phosphorylation site [posttranslational modification]
378806015651	intermolecular recognition site; other site
378806015652	dimerization interface [polypeptide binding]; other site
378806015653	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806015654	Zn2+ binding site [ion binding]; other site
378806015655	Mg2+ binding site [ion binding]; other site
378806015656	HEAT repeats; Region: HEAT_2; pfam13646
378806015657	HEAT repeats; Region: HEAT_2; pfam13646
378806015658	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
378806015659	active site
378806015660	MoxR-like ATPases [General function prediction only]; Region: COG0714
378806015661	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806015662	Walker A motif; other site
378806015663	ATP binding site [chemical binding]; other site
378806015664	Walker B motif; other site
378806015665	arginine finger; other site
378806015666	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
378806015667	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
378806015668	metal ion-dependent adhesion site (MIDAS); other site
378806015669	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
378806015670	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806015671	ATP binding site [chemical binding]; other site
378806015672	putative Mg++ binding site [ion binding]; other site
378806015673	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806015674	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
378806015675	nucleotide binding region [chemical binding]; other site
378806015676	ATP-binding site [chemical binding]; other site
378806015677	Smr domain; Region: Smr; pfam01713
378806015678	Protein of unknown function DUF72; Region: DUF72; pfam01904
378806015679	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
378806015680	SnoaL-like domain; Region: SnoaL_3; pfam13474
378806015681	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806015682	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806015683	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
378806015684	Surface antigen; Region: Bac_surface_Ag; pfam01103
378806015685	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
378806015686	substrate binding site [chemical binding]; other site
378806015687	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
378806015688	active site
378806015689	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
378806015690	dimer interface [polypeptide binding]; other site
378806015691	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
378806015692	Ligand Binding Site [chemical binding]; other site
378806015693	Molecular Tunnel; other site
378806015694	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
378806015695	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
378806015696	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
378806015697	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
378806015698	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806015699	DNA-binding site [nucleotide binding]; DNA binding site
378806015700	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806015701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806015702	homodimer interface [polypeptide binding]; other site
378806015703	catalytic residue [active]
378806015704	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
378806015705	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
378806015706	dimer interface [polypeptide binding]; other site
378806015707	anticodon binding site; other site
378806015708	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
378806015709	homodimer interface [polypeptide binding]; other site
378806015710	motif 1; other site
378806015711	active site
378806015712	motif 2; other site
378806015713	GAD domain; Region: GAD; pfam02938
378806015714	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
378806015715	active site
378806015716	motif 3; other site
378806015717	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806015718	Zn binding site [ion binding]; other site
378806015719	YHS domain; Region: YHS; pfam04945
378806015720	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
378806015721	DHH family; Region: DHH; pfam01368
378806015722	DHHA1 domain; Region: DHHA1; pfam02272
378806015723	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
378806015724	PLD-like domain; Region: PLDc_2; pfam13091
378806015725	putative active site [active]
378806015726	catalytic site [active]
378806015727	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
378806015728	PLD-like domain; Region: PLDc_2; pfam13091
378806015729	putative active site [active]
378806015730	catalytic site [active]
378806015731	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
378806015732	CoA binding domain; Region: CoA_binding_2; pfam13380
378806015733	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
378806015734	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
378806015735	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
378806015736	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806015737	Coenzyme A binding pocket [chemical binding]; other site
378806015738	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
378806015739	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806015740	active site
378806015741	DNA binding site [nucleotide binding]
378806015742	Int/Topo IB signature motif; other site
378806015743	Helix-turn-helix domain; Region: HTH_17; pfam12728
378806015744	DDE superfamily endonuclease; Region: DDE_3; pfam13358
378806015745	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806015746	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806015747	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806015748	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806015749	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806015750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806015751	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806015752	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806015753	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806015754	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806015755	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
378806015756	Transposase domain (DUF772); Region: DUF772; pfam05598
378806015757	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806015758	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
378806015759	DDE superfamily endonuclease; Region: DDE_3; pfam13358
378806015760	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806015761	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806015762	metal binding site [ion binding]; metal-binding site
378806015763	Nudix hydrolase homolog; Region: PLN02791
378806015764	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
378806015765	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
378806015766	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806015767	Coenzyme A binding pocket [chemical binding]; other site
378806015768	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806015769	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806015770	active site
378806015771	ATP binding site [chemical binding]; other site
378806015772	substrate binding site [chemical binding]; other site
378806015773	activation loop (A-loop); other site
378806015774	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015775	binding surface
378806015776	TPR motif; other site
378806015777	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015778	TPR motif; other site
378806015779	binding surface
378806015780	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
378806015781	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
378806015782	nucleophilic elbow; other site
378806015783	catalytic triad; other site
378806015784	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
378806015785	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806015786	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806015787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806015788	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
378806015789	NADP binding site [chemical binding]; other site
378806015790	active site
378806015791	regulatory binding site [polypeptide binding]; other site
378806015792	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
378806015793	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
378806015794	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
378806015795	active site residue [active]
378806015796	Rhodanese Homology Domain; Region: RHOD; smart00450
378806015797	active site residue [active]
378806015798	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
378806015799	active site residue [active]
378806015800	Uncharacterized conserved protein [Function unknown]; Region: COG3482
378806015801	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806015802	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806015803	phosphopeptide binding site; other site
378806015804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806015805	Walker A motif; other site
378806015806	ATP binding site [chemical binding]; other site
378806015807	Walker B motif; other site
378806015808	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806015809	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806015810	DNA-binding site [nucleotide binding]; DNA binding site
378806015811	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
378806015812	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
378806015813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806015814	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806015815	dimer interface [polypeptide binding]; other site
378806015816	phosphorylation site [posttranslational modification]
378806015817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806015818	ATP binding site [chemical binding]; other site
378806015819	Mg2+ binding site [ion binding]; other site
378806015820	G-X-G motif; other site
378806015821	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
378806015822	nucleotide binding site [chemical binding]; other site
378806015823	putative NEF/HSP70 interaction site [polypeptide binding]; other site
378806015824	SBD interface [polypeptide binding]; other site
378806015825	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
378806015826	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
378806015827	Protein export membrane protein; Region: SecD_SecF; pfam02355
378806015828	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
378806015829	protein-export membrane protein SecD; Region: secD; TIGR01129
378806015830	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
378806015831	Preprotein translocase subunit; Region: YajC; pfam02699
378806015832	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
378806015833	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
378806015834	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
378806015835	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
378806015836	Stage II sporulation protein; Region: SpoIID; pfam08486
378806015837	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
378806015838	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
378806015839	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806015840	FeS/SAM binding site; other site
378806015841	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
378806015842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
378806015843	Radical SAM superfamily; Region: Radical_SAM; pfam04055
378806015844	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806015845	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806015846	active site
378806015847	ATP binding site [chemical binding]; other site
378806015848	substrate binding site [chemical binding]; other site
378806015849	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806015850	substrate binding site [chemical binding]; other site
378806015851	activation loop (A-loop); other site
378806015852	activation loop (A-loop); other site
378806015853	PEGA domain; Region: PEGA; pfam08308
378806015854	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
378806015855	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
378806015856	catalytic site [active]
378806015857	G-X2-G-X-G-K; other site
378806015858	hypothetical protein; Provisional; Region: PRK11820
378806015859	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
378806015860	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
378806015861	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
378806015862	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
378806015863	putative active site [active]
378806015864	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806015865	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
378806015866	active site
378806015867	nucleotide binding site [chemical binding]; other site
378806015868	HIGH motif; other site
378806015869	KMSKS motif; other site
378806015870	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
378806015871	substrate binding site [chemical binding]; other site
378806015872	ATP binding site [chemical binding]; other site
378806015873	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
378806015874	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806015875	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806015876	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806015877	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
378806015878	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
378806015879	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806015880	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
378806015881	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
378806015882	active site
378806015883	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
378806015884	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
378806015885	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806015886	Walker A/P-loop; other site
378806015887	ATP binding site [chemical binding]; other site
378806015888	Q-loop/lid; other site
378806015889	ABC transporter signature motif; other site
378806015890	Walker B; other site
378806015891	D-loop; other site
378806015892	H-loop/switch region; other site
378806015893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
378806015894	active site
378806015895	phosphorylation site [posttranslational modification]
378806015896	intermolecular recognition site; other site
378806015897	dimerization interface [polypeptide binding]; other site
378806015898	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806015899	DnaJ domain; Region: DnaJ; pfam00226
378806015900	TPR repeat; Region: TPR_11; pfam13414
378806015901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806015902	binding surface
378806015903	TPR motif; other site
378806015904	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
378806015905	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
378806015906	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
378806015907	Ligand binding site; other site
378806015908	Putative Catalytic site; other site
378806015909	DXD motif; other site
378806015910	MarC family integral membrane protein; Region: MarC; cl00919
378806015911	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806015912	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806015913	ligand binding site [chemical binding]; other site
378806015914	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
378806015915	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
378806015916	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
378806015917	active site
378806015918	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
378806015919	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
378806015920	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
378806015921	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
378806015922	trimer interface [polypeptide binding]; other site
378806015923	active site
378806015924	UDP-GlcNAc binding site [chemical binding]; other site
378806015925	lipid binding site [chemical binding]; lipid-binding site
378806015926	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
378806015927	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806015928	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
378806015929	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806015930	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806015931	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806015932	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806015933	Surface antigen; Region: Bac_surface_Ag; pfam01103
378806015934	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
378806015935	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
378806015936	Walker A/P-loop; other site
378806015937	ATP binding site [chemical binding]; other site
378806015938	Q-loop/lid; other site
378806015939	ABC transporter signature motif; other site
378806015940	Walker B; other site
378806015941	D-loop; other site
378806015942	H-loop/switch region; other site
378806015943	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
378806015944	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
378806015945	FtsX-like permease family; Region: FtsX; pfam02687
378806015946	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
378806015947	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
378806015948	dimer interface [polypeptide binding]; other site
378806015949	putative anticodon binding site; other site
378806015950	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
378806015951	motif 1; other site
378806015952	active site
378806015953	motif 2; other site
378806015954	motif 3; other site
378806015955	Putative zinc-finger; Region: zf-HC2; pfam13490
378806015956	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
378806015957	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806015958	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806015959	DNA binding residues [nucleotide binding]
378806015960	peptide chain release factor 2; Validated; Region: prfB; PRK00578
378806015961	This domain is found in peptide chain release factors; Region: PCRF; smart00937
378806015962	RF-1 domain; Region: RF-1; pfam00472
378806015963	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
378806015964	Cupin domain; Region: Cupin_2; cl17218
378806015965	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
378806015966	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
378806015967	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806015968	Zn2+ binding site [ion binding]; other site
378806015969	Mg2+ binding site [ion binding]; other site
378806015970	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
378806015971	PhoH-like protein; Region: PhoH; pfam02562
378806015972	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806015973	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806015974	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
378806015975	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
378806015976	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
378806015977	homodimer interface [polypeptide binding]; other site
378806015978	metal binding site [ion binding]; metal-binding site
378806015979	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
378806015980	homodimer interface [polypeptide binding]; other site
378806015981	active site
378806015982	putative chemical substrate binding site [chemical binding]; other site
378806015983	metal binding site [ion binding]; metal-binding site
378806015984	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
378806015985	active site
378806015986	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
378806015987	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
378806015988	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
378806015989	HIGH motif; other site
378806015990	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
378806015991	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806015992	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806015993	active site
378806015994	KMSKS motif; other site
378806015995	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
378806015996	tRNA binding surface [nucleotide binding]; other site
378806015997	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
378806015998	hydroxyglutarate oxidase; Provisional; Region: PRK11728
378806015999	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
378806016000	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806016001	Walker A/P-loop; other site
378806016002	ATP binding site [chemical binding]; other site
378806016003	Q-loop/lid; other site
378806016004	ABC transporter signature motif; other site
378806016005	Walker B; other site
378806016006	D-loop; other site
378806016007	H-loop/switch region; other site
378806016008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016009	Response regulator receiver domain; Region: Response_reg; pfam00072
378806016010	active site
378806016011	phosphorylation site [posttranslational modification]
378806016012	intermolecular recognition site; other site
378806016013	dimerization interface [polypeptide binding]; other site
378806016014	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
378806016015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016016	active site
378806016017	phosphorylation site [posttranslational modification]
378806016018	intermolecular recognition site; other site
378806016019	dimerization interface [polypeptide binding]; other site
378806016020	CheB methylesterase; Region: CheB_methylest; pfam01339
378806016021	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
378806016022	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
378806016023	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806016024	S-adenosylmethionine binding site [chemical binding]; other site
378806016025	HEAT repeats; Region: HEAT_2; pfam13646
378806016026	HEAT repeats; Region: HEAT_2; pfam13646
378806016027	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
378806016028	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
378806016029	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
378806016030	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
378806016031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806016032	ATP binding site [chemical binding]; other site
378806016033	Mg2+ binding site [ion binding]; other site
378806016034	G-X-G motif; other site
378806016035	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
378806016036	Response regulator receiver domain; Region: Response_reg; pfam00072
378806016037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016038	active site
378806016039	phosphorylation site [posttranslational modification]
378806016040	intermolecular recognition site; other site
378806016041	dimerization interface [polypeptide binding]; other site
378806016042	Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789
378806016043	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
378806016044	putative RNA binding site [nucleotide binding]; other site
378806016045	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
378806016046	homopentamer interface [polypeptide binding]; other site
378806016047	active site
378806016048	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
378806016049	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
378806016050	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
378806016051	dimerization interface [polypeptide binding]; other site
378806016052	active site
378806016053	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
378806016054	Lumazine binding domain; Region: Lum_binding; pfam00677
378806016055	Lumazine binding domain; Region: Lum_binding; pfam00677
378806016056	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
378806016057	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
378806016058	catalytic motif [active]
378806016059	Zn binding site [ion binding]; other site
378806016060	RibD C-terminal domain; Region: RibD_C; cl17279
378806016061	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
378806016062	ATP cone domain; Region: ATP-cone; pfam03477
378806016063	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
378806016064	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
378806016065	dimer interface [polypeptide binding]; other site
378806016066	active site
378806016067	glycine-pyridoxal phosphate binding site [chemical binding]; other site
378806016068	folate binding site [chemical binding]; other site
378806016069	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
378806016070	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
378806016071	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
378806016072	dimer interface [polypeptide binding]; other site
378806016073	active site
378806016074	acyl carrier protein; Provisional; Region: acpP; PRK00982
378806016075	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
378806016076	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
378806016077	NAD(P) binding site [chemical binding]; other site
378806016078	homotetramer interface [polypeptide binding]; other site
378806016079	homodimer interface [polypeptide binding]; other site
378806016080	active site
378806016081	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
378806016082	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
378806016083	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
378806016084	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
378806016085	dimer interface [polypeptide binding]; other site
378806016086	active site
378806016087	CoA binding pocket [chemical binding]; other site
378806016088	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
378806016089	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
378806016090	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806016091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016092	active site
378806016093	phosphorylation site [posttranslational modification]
378806016094	intermolecular recognition site; other site
378806016095	dimerization interface [polypeptide binding]; other site
378806016096	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806016097	DNA binding site [nucleotide binding]
378806016098	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806016099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806016100	dimer interface [polypeptide binding]; other site
378806016101	phosphorylation site [posttranslational modification]
378806016102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806016103	ATP binding site [chemical binding]; other site
378806016104	Mg2+ binding site [ion binding]; other site
378806016105	G-X-G motif; other site
378806016106	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
378806016107	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806016108	active site
378806016109	metal binding site [ion binding]; metal-binding site
378806016110	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
378806016111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016112	active site
378806016113	phosphorylation site [posttranslational modification]
378806016114	intermolecular recognition site; other site
378806016115	dimerization interface [polypeptide binding]; other site
378806016116	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806016117	DNA binding site [nucleotide binding]
378806016118	PBP superfamily domain; Region: PBP_like_2; cl17296
378806016119	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
378806016120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806016121	dimer interface [polypeptide binding]; other site
378806016122	conserved gate region; other site
378806016123	putative PBP binding loops; other site
378806016124	ABC-ATPase subunit interface; other site
378806016125	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
378806016126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806016127	ABC-ATPase subunit interface; other site
378806016128	phosphate transporter ATP-binding protein; Provisional; Region: PRK14242
378806016129	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
378806016130	Walker A/P-loop; other site
378806016131	ATP binding site [chemical binding]; other site
378806016132	Q-loop/lid; other site
378806016133	ABC transporter signature motif; other site
378806016134	Walker B; other site
378806016135	D-loop; other site
378806016136	H-loop/switch region; other site
378806016137	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
378806016138	PhoU domain; Region: PhoU; pfam01895
378806016139	PhoU domain; Region: PhoU; pfam01895
378806016140	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
378806016141	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
378806016142	ligand binding site; other site
378806016143	Response regulator receiver domain; Region: Response_reg; pfam00072
378806016144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016145	active site
378806016146	phosphorylation site [posttranslational modification]
378806016147	intermolecular recognition site; other site
378806016148	dimerization interface [polypeptide binding]; other site
378806016149	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
378806016150	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
378806016151	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
378806016152	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
378806016153	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
378806016154	putative active site [active]
378806016155	putative metal binding site [ion binding]; other site
378806016156	signal recognition particle protein; Provisional; Region: PRK10867
378806016157	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
378806016158	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
378806016159	P loop; other site
378806016160	GTP binding site [chemical binding]; other site
378806016161	Signal peptide binding domain; Region: SRP_SPB; pfam02978
378806016162	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806016163	Bacterial Ig-like domain; Region: Big_5; pfam13205
378806016164	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806016165	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
378806016166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
378806016167	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
378806016168	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
378806016169	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
378806016170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016171	binding surface
378806016172	TPR motif; other site
378806016173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016174	TPR motif; other site
378806016175	binding surface
378806016176	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016177	binding surface
378806016178	TPR motif; other site
378806016179	tetratricopeptide repeat protein; Provisional; Region: PRK11788
378806016180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016181	binding surface
378806016182	TPR motif; other site
378806016183	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806016184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016185	binding surface
378806016186	TPR motif; other site
378806016187	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806016188	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806016189	phosphopeptide binding site; other site
378806016190	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
378806016191	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016192	binding surface
378806016193	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806016194	TPR motif; other site
378806016195	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806016196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016197	TPR motif; other site
378806016198	binding surface
378806016199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016200	TPR motif; other site
378806016201	binding surface
378806016202	TPR repeat; Region: TPR_11; pfam13414
378806016203	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016204	binding surface
378806016205	TPR motif; other site
378806016206	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
378806016207	hypothetical protein; Validated; Region: PRK08116
378806016208	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
378806016209	Walker A motif; other site
378806016210	ATP binding site [chemical binding]; other site
378806016211	Walker B motif; other site
378806016212	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806016213	putative binding surface; other site
378806016214	active site
378806016215	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
378806016216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016217	active site
378806016218	phosphorylation site [posttranslational modification]
378806016219	intermolecular recognition site; other site
378806016220	dimerization interface [polypeptide binding]; other site
378806016221	CheB methylesterase; Region: CheB_methylest; pfam01339
378806016222	Integral membrane protein TerC family; Region: TerC; cl10468
378806016223	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
378806016224	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
378806016225	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
378806016226	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
378806016227	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
378806016228	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
378806016229	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
378806016230	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806016231	NHL repeat; Region: NHL; pfam01436
378806016232	aspartate kinase; Reviewed; Region: PRK06635
378806016233	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
378806016234	putative catalytic residues [active]
378806016235	putative nucleotide binding site [chemical binding]; other site
378806016236	putative aspartate binding site [chemical binding]; other site
378806016237	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
378806016238	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806016239	Walker A/P-loop; other site
378806016240	ATP binding site [chemical binding]; other site
378806016241	Q-loop/lid; other site
378806016242	ABC transporter signature motif; other site
378806016243	Walker B; other site
378806016244	D-loop; other site
378806016245	H-loop/switch region; other site
378806016246	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
378806016247	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
378806016248	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
378806016249	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
378806016250	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
378806016251	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
378806016252	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806016253	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
378806016254	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806016255	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806016256	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806016257	DNA binding residues [nucleotide binding]
378806016258	Putative zinc-finger; Region: zf-HC2; pfam13490
378806016259	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
378806016260	Caspase domain; Region: Peptidase_C14; pfam00656
378806016261	CHRD domain; Region: CHRD; pfam07452
378806016262	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
378806016263	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
378806016264	active site
378806016265	Ap6A binding site [chemical binding]; other site
378806016266	nudix motif; other site
378806016267	metal binding site [ion binding]; metal-binding site
378806016268	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
378806016269	oligomerisation interface [polypeptide binding]; other site
378806016270	mobile loop; other site
378806016271	roof hairpin; other site
378806016272	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
378806016273	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
378806016274	ring oligomerisation interface [polypeptide binding]; other site
378806016275	ATP/Mg binding site [chemical binding]; other site
378806016276	stacking interactions; other site
378806016277	hinge regions; other site
378806016278	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
378806016279	GSH binding site [chemical binding]; other site
378806016280	catalytic residues [active]
378806016281	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806016282	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806016283	phosphopeptide binding site; other site
378806016284	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806016285	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806016286	Walker A motif; other site
378806016287	ATP binding site [chemical binding]; other site
378806016288	Walker B motif; other site
378806016289	arginine finger; other site
378806016290	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
378806016291	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
378806016292	Walker A/P-loop; other site
378806016293	ATP binding site [chemical binding]; other site
378806016294	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
378806016295	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
378806016296	Q-loop/lid; other site
378806016297	ABC transporter signature motif; other site
378806016298	Walker B; other site
378806016299	D-loop; other site
378806016300	H-loop/switch region; other site
378806016301	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
378806016302	Domain of unknown function DUF21; Region: DUF21; pfam01595
378806016303	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
378806016304	Transporter associated domain; Region: CorC_HlyC; smart01091
378806016305	TPR repeat; Region: TPR_11; pfam13414
378806016306	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016307	binding surface
378806016308	TPR motif; other site
378806016309	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016310	binding surface
378806016311	TPR motif; other site
378806016312	TPR repeat; Region: TPR_11; pfam13414
378806016313	TPR repeat; Region: TPR_11; pfam13414
378806016314	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016315	binding surface
378806016316	TPR motif; other site
378806016317	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
378806016318	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
378806016319	putative active site [active]
378806016320	putative metal binding site [ion binding]; other site
378806016321	peptide chain release factor 1; Validated; Region: prfA; PRK00591
378806016322	PCRF domain; Region: PCRF; pfam03462
378806016323	RF-1 domain; Region: RF-1; pfam00472
378806016324	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
378806016325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806016326	S-adenosylmethionine binding site [chemical binding]; other site
378806016327	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
378806016328	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
378806016329	hinge; other site
378806016330	active site
378806016331	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
378806016332	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
378806016333	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
378806016334	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
378806016335	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
378806016336	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
378806016337	active site
378806016338	catalytic residues [active]
378806016339	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
378806016340	dimer interface [polypeptide binding]; other site
378806016341	catalytic triad [active]
378806016342	peroxidatic and resolving cysteines [active]
378806016343	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806016344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806016345	S-adenosylmethionine binding site [chemical binding]; other site
378806016346	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806016347	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
378806016348	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806016349	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
378806016350	BNR repeat-like domain; Region: BNR_2; pfam13088
378806016351	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
378806016352	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
378806016353	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
378806016354	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806016355	catalytic residue [active]
378806016356	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
378806016357	hypothetical protein; Provisional; Region: PRK05409
378806016358	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
378806016359	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806016360	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806016361	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806016362	non-specific DNA binding site [nucleotide binding]; other site
378806016363	salt bridge; other site
378806016364	sequence-specific DNA binding site [nucleotide binding]; other site
378806016365	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
378806016366	Domain of unknown function (DUF955); Region: DUF955; pfam06114
378806016367	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
378806016368	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806016369	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806016370	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
378806016371	multifunctional aminopeptidase A; Provisional; Region: PRK00913
378806016372	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
378806016373	interface (dimer of trimers) [polypeptide binding]; other site
378806016374	Substrate-binding/catalytic site; other site
378806016375	Zn-binding sites [ion binding]; other site
378806016376	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
378806016377	active site
378806016378	dimer interface [polypeptide binding]; other site
378806016379	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806016380	Thioredoxin; Region: Thioredoxin_4; pfam13462
378806016381	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
378806016382	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
378806016383	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
378806016384	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
378806016385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806016386	Walker A motif; other site
378806016387	ATP binding site [chemical binding]; other site
378806016388	Walker B motif; other site
378806016389	arginine finger; other site
378806016390	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
378806016391	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
378806016392	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
378806016393	NAD(P) binding site [chemical binding]; other site
378806016394	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
378806016395	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806016396	sugar binding site [chemical binding]; other site
378806016397	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
378806016398	metal binding site [ion binding]; metal-binding site
378806016399	ligand binding site [chemical binding]; other site
378806016400	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576
378806016401	putative ligand binding site [chemical binding]; other site
378806016402	putative catalytic site [active]
378806016403	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
378806016404	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
378806016405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
378806016406	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
378806016407	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
378806016408	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
378806016409	Mechanosensitive ion channel; Region: MS_channel; pfam00924
378806016410	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806016411	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
378806016412	Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608
378806016413	PilZ domain; Region: PilZ; pfam07238
378806016414	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
378806016415	WHG domain; Region: WHG; pfam13305
378806016416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806016417	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806016418	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806016419	putative sugar binding sites [chemical binding]; other site
378806016420	Q-X-W motif; other site
378806016421	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806016422	Interdomain contacts; other site
378806016423	Cytokine receptor motif; other site
378806016424	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806016425	Interdomain contacts; other site
378806016426	Cytokine receptor motif; other site
378806016427	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
378806016428	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
378806016429	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806016430	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
378806016431	active site
378806016432	metal binding site [ion binding]; metal-binding site
378806016433	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806016434	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
378806016435	protein-splicing catalytic site; other site
378806016436	thioester formation/cholesterol transfer; other site
378806016437	intein N-terminal splicing region; Region: intein_Nterm; TIGR01445
378806016438	protein-splicing catalytic site; other site
378806016439	thioester formation/cholesterol transfer; other site
378806016440	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
378806016441	protein-splicing catalytic site; other site
378806016442	thioester formation/cholesterol transfer; other site
378806016443	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
378806016444	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806016445	NAD(P) binding site [chemical binding]; other site
378806016446	active site
378806016447	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806016448	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
378806016449	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806016450	Protein kinase domain; Region: Pkinase; pfam00069
378806016451	active site
378806016452	ATP binding site [chemical binding]; other site
378806016453	substrate binding site [chemical binding]; other site
378806016454	activation loop (A-loop); other site
378806016455	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
378806016456	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806016457	active site
378806016458	HIGH motif; other site
378806016459	nucleotide binding site [chemical binding]; other site
378806016460	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806016461	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806016462	active site
378806016463	KMSKS motif; other site
378806016464	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
378806016465	tRNA binding surface [nucleotide binding]; other site
378806016466	anticodon binding site; other site
378806016467	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
378806016468	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
378806016469	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806016470	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806016471	CotH protein; Region: CotH; pfam08757
378806016472	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
378806016473	RuvA N terminal domain; Region: RuvA_N; pfam01330
378806016474	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
378806016475	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
378806016476	active site
378806016477	putative DNA-binding cleft [nucleotide binding]; other site
378806016478	dimer interface [polypeptide binding]; other site
378806016479	hypothetical protein; Validated; Region: PRK00110
378806016480	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806016481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016482	active site
378806016483	phosphorylation site [posttranslational modification]
378806016484	intermolecular recognition site; other site
378806016485	dimerization interface [polypeptide binding]; other site
378806016486	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806016487	Glutamine amidotransferases class-II; Region: GATase_4; pfam13230
378806016488	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
378806016489	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
378806016490	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
378806016491	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
378806016492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
378806016493	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
378806016494	Uncharacterized conserved protein [Function unknown]; Region: COG2308
378806016495	HEAT repeats; Region: HEAT_2; pfam13646
378806016496	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
378806016497	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806016498	NMT1/THI5 like; Region: NMT1; pfam09084
378806016499	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
378806016500	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
378806016501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806016502	dimer interface [polypeptide binding]; other site
378806016503	conserved gate region; other site
378806016504	putative PBP binding loops; other site
378806016505	ABC-ATPase subunit interface; other site
378806016506	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
378806016507	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
378806016508	Walker A/P-loop; other site
378806016509	ATP binding site [chemical binding]; other site
378806016510	Q-loop/lid; other site
378806016511	ABC transporter signature motif; other site
378806016512	Walker B; other site
378806016513	D-loop; other site
378806016514	H-loop/switch region; other site
378806016515	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
378806016516	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
378806016517	active site
378806016518	putative substrate binding pocket [chemical binding]; other site
378806016519	Survival protein SurE; Region: SurE; pfam01975
378806016520	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
378806016521	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806016522	S-adenosylmethionine binding site [chemical binding]; other site
378806016523	Thymidylate synthase; Region: Thymidylat_synt; pfam00303
378806016524	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
378806016525	dimerization interface [polypeptide binding]; other site
378806016526	active site
378806016527	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806016528	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806016529	putative sugar binding sites [chemical binding]; other site
378806016530	Q-X-W motif; other site
378806016531	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
378806016532	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
378806016533	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
378806016534	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
378806016535	putative active site [active]
378806016536	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
378806016537	hypothetical protein; Reviewed; Region: PRK09588
378806016538	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
378806016539	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
378806016540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806016541	Walker A motif; other site
378806016542	ATP binding site [chemical binding]; other site
378806016543	Walker B motif; other site
378806016544	arginine finger; other site
378806016545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016546	active site
378806016547	phosphorylation site [posttranslational modification]
378806016548	intermolecular recognition site; other site
378806016549	dimerization interface [polypeptide binding]; other site
378806016550	Cache domain; Region: Cache_1; pfam02743
378806016551	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806016552	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806016553	dimerization interface [polypeptide binding]; other site
378806016554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806016555	ATP binding site [chemical binding]; other site
378806016556	Mg2+ binding site [ion binding]; other site
378806016557	G-X-G motif; other site
378806016558	Uncharacterized conserved protein [Function unknown]; Region: COG3391
378806016559	Uncharacterized conserved protein [Function unknown]; Region: COG3391
378806016560	DTW domain; Region: DTW; cl01221
378806016561	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
378806016562	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
378806016563	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
378806016564	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806016565	DsbD alpha interface [polypeptide binding]; other site
378806016566	catalytic residues [active]
378806016567	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cd02106
378806016568	cysteine desulfurase; Provisional; Region: PRK14012
378806016569	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
378806016570	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806016571	catalytic residue [active]
378806016572	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
378806016573	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
378806016574	trimerization site [polypeptide binding]; other site
378806016575	active site
378806016576	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
378806016577	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806016578	HSP70 interaction site [polypeptide binding]; other site
378806016579	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
378806016580	Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991
378806016581	nucleotide binding site [chemical binding]; other site
378806016582	putative NEF/HSP70 interaction site [polypeptide binding]; other site
378806016583	SBD interface [polypeptide binding]; other site
378806016584	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
378806016585	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
378806016586	catalytic loop [active]
378806016587	iron binding site [ion binding]; other site
378806016588	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
378806016589	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
378806016590	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
378806016591	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
378806016592	diphosphomevalonate decarboxylase; Region: PLN02407
378806016593	diphosphomevalonate decarboxylase; Region: PLN02407
378806016594	mevalonate kinase; Region: mevalon_kin; TIGR00549
378806016595	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
378806016596	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
378806016597	homodimer interface [polypeptide binding]; other site
378806016598	catalytic residues [active]
378806016599	NAD binding site [chemical binding]; other site
378806016600	substrate binding pocket [chemical binding]; other site
378806016601	flexible flap; other site
378806016602	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
378806016603	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
378806016604	homotetramer interface [polypeptide binding]; other site
378806016605	FMN binding site [chemical binding]; other site
378806016606	homodimer contacts [polypeptide binding]; other site
378806016607	putative active site [active]
378806016608	putative substrate binding site [chemical binding]; other site
378806016609	synthase/transferase; Region: PLN02316
378806016610	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806016611	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806016612	dimerization interface [polypeptide binding]; other site
378806016613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806016614	dimer interface [polypeptide binding]; other site
378806016615	phosphorylation site [posttranslational modification]
378806016616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806016617	ATP binding site [chemical binding]; other site
378806016618	Mg2+ binding site [ion binding]; other site
378806016619	G-X-G motif; other site
378806016620	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806016621	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806016622	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806016623	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
378806016624	active site
378806016625	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806016626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016627	active site
378806016628	phosphorylation site [posttranslational modification]
378806016629	intermolecular recognition site; other site
378806016630	dimerization interface [polypeptide binding]; other site
378806016631	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806016632	Response regulator receiver domain; Region: Response_reg; pfam00072
378806016633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016634	active site
378806016635	phosphorylation site [posttranslational modification]
378806016636	intermolecular recognition site; other site
378806016637	dimerization interface [polypeptide binding]; other site
378806016638	GAF domain; Region: GAF_3; pfam13492
378806016639	GAF domain; Region: GAF_2; pfam13185
378806016640	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806016641	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806016642	metal binding site [ion binding]; metal-binding site
378806016643	active site
378806016644	I-site; other site
378806016645	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
378806016646	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
378806016647	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
378806016648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806016649	ribonucleoside--diphosphate reductase large subunit; Region: PLN02437
378806016650	ATP cone domain; Region: ATP-cone; pfam03477
378806016651	Class I ribonucleotide reductase; Region: RNR_I; cd01679
378806016652	active site
378806016653	dimer interface [polypeptide binding]; other site
378806016654	catalytic residues [active]
378806016655	effector binding site; other site
378806016656	R2 peptide binding site; other site
378806016657	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
378806016658	dimer interface [polypeptide binding]; other site
378806016659	putative radical transfer pathway; other site
378806016660	diiron center [ion binding]; other site
378806016661	tyrosyl radical; other site
378806016662	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
378806016663	active site
378806016664	thymidine kinase; Provisional; Region: PRK04296
378806016665	regulatory protein SpoVG; Reviewed; Region: PRK13259
378806016666	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
378806016667	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
378806016668	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
378806016669	active site
378806016670	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
378806016671	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
378806016672	5S rRNA interface [nucleotide binding]; other site
378806016673	CTC domain interface [polypeptide binding]; other site
378806016674	L16 interface [polypeptide binding]; other site
378806016675	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
378806016676	putative active site [active]
378806016677	catalytic residue [active]
378806016678	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
378806016679	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
378806016680	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
378806016681	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
378806016682	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
378806016683	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
378806016684	replicative DNA helicase; Region: DnaB; TIGR00665
378806016685	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
378806016686	Walker A motif; other site
378806016687	ATP binding site [chemical binding]; other site
378806016688	Walker B motif; other site
378806016689	DNA binding loops [nucleotide binding]
378806016690	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
378806016691	substrate binding site [chemical binding]; other site
378806016692	ATP binding site [chemical binding]; other site
378806016693	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
378806016694	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
378806016695	catalytic triad [active]
378806016696	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
378806016697	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
378806016698	trimer interface [polypeptide binding]; other site
378806016699	active site
378806016700	substrate binding site [chemical binding]; other site
378806016701	CoA binding site [chemical binding]; other site
378806016702	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806016703	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806016704	phosphopeptide binding site; other site
378806016705	S-formylglutathione hydrolase; Region: PLN02442
378806016706	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
378806016707	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
378806016708	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
378806016709	substrate binding site [chemical binding]; other site
378806016710	catalytic Zn binding site [ion binding]; other site
378806016711	NAD binding site [chemical binding]; other site
378806016712	structural Zn binding site [ion binding]; other site
378806016713	dimer interface [polypeptide binding]; other site
378806016714	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
378806016715	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
378806016716	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
378806016717	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806016718	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
378806016719	Clp amino terminal domain; Region: Clp_N; pfam02861
378806016720	Clp amino terminal domain; Region: Clp_N; pfam02861
378806016721	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806016722	Walker A motif; other site
378806016723	ATP binding site [chemical binding]; other site
378806016724	Walker B motif; other site
378806016725	arginine finger; other site
378806016726	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806016727	Walker A motif; other site
378806016728	ATP binding site [chemical binding]; other site
378806016729	Walker B motif; other site
378806016730	arginine finger; other site
378806016731	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
378806016732	RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001
378806016733	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806016734	DNA binding residues [nucleotide binding]
378806016735	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806016736	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806016737	active site
378806016738	ATP binding site [chemical binding]; other site
378806016739	substrate binding site [chemical binding]; other site
378806016740	activation loop (A-loop); other site
378806016741	AAA ATPase domain; Region: AAA_16; pfam13191
378806016742	Uncharacterized conserved protein [Function unknown]; Region: COG1262
378806016743	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
378806016744	Arginine repressor [Transcription]; Region: ArgR; COG1438
378806016745	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
378806016746	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
378806016747	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
378806016748	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
378806016749	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
378806016750	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
378806016751	nucleotide binding site [chemical binding]; other site
378806016752	substrate binding site [chemical binding]; other site
378806016753	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
378806016754	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
378806016755	metal binding site [ion binding]; metal-binding site
378806016756	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
378806016757	active sites [active]
378806016758	Lyase; Region: Lyase_1; pfam00206
378806016759	tetramer interface [polypeptide binding]; other site
378806016760	argininosuccinate synthase; Provisional; Region: PRK13820
378806016761	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
378806016762	Ligand Binding Site [chemical binding]; other site
378806016763	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
378806016764	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
378806016765	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
378806016766	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
378806016767	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
378806016768	active site
378806016769	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
378806016770	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
378806016771	dimerization interface 3.5A [polypeptide binding]; other site
378806016772	active site
378806016773	HflC protein; Region: hflC; TIGR01932
378806016774	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
378806016775	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
378806016776	HflK protein; Region: hflK; TIGR01933
378806016777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806016778	putative substrate translocation pore; other site
378806016779	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
378806016780	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
378806016781	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
378806016782	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806016783	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806016784	active site
378806016785	ATP binding site [chemical binding]; other site
378806016786	substrate binding site [chemical binding]; other site
378806016787	activation loop (A-loop); other site
378806016788	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
378806016789	putative RNA binding site [nucleotide binding]; other site
378806016790	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
378806016791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806016792	S-adenosylmethionine binding site [chemical binding]; other site
378806016793	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
378806016794	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806016795	active site
378806016796	oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154
378806016797	oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154
378806016798	oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154
378806016799	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806016800	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806016801	dimer interface [polypeptide binding]; other site
378806016802	phosphorylation site [posttranslational modification]
378806016803	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806016804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016805	active site
378806016806	phosphorylation site [posttranslational modification]
378806016807	intermolecular recognition site; other site
378806016808	dimerization interface [polypeptide binding]; other site
378806016809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806016810	Walker A motif; other site
378806016811	ATP binding site [chemical binding]; other site
378806016812	Walker B motif; other site
378806016813	arginine finger; other site
378806016814	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806016815	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
378806016816	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806016817	ligand binding site [chemical binding]; other site
378806016818	flexible hinge region; other site
378806016819	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
378806016820	putative switch regulator; other site
378806016821	non-specific DNA interactions [nucleotide binding]; other site
378806016822	DNA binding site [nucleotide binding]
378806016823	sequence specific DNA binding site [nucleotide binding]; other site
378806016824	putative cAMP binding site [chemical binding]; other site
378806016825	MutS domain III; Region: MutS_III; pfam05192
378806016826	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806016827	Walker A/P-loop; other site
378806016828	ATP binding site [chemical binding]; other site
378806016829	Q-loop/lid; other site
378806016830	ABC transporter signature motif; other site
378806016831	Walker B; other site
378806016832	D-loop; other site
378806016833	H-loop/switch region; other site
378806016834	CHASE3 domain; Region: CHASE3; pfam05227
378806016835	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
378806016836	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806016837	dimer interface [polypeptide binding]; other site
378806016838	putative CheW interface [polypeptide binding]; other site
378806016839	methylthioribulose-1-phosphate dehydratase; Region: salvage_mtnB; TIGR03328
378806016840	intersubunit interface [polypeptide binding]; other site
378806016841	active site
378806016842	Zn2+ binding site [ion binding]; other site
378806016843	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
378806016844	Cupin domain; Region: Cupin_2; cl17218
378806016845	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
378806016846	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806016847	motif I; other site
378806016848	motif II; other site
378806016849	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
378806016850	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
378806016851	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
378806016852	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
378806016853	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
378806016854	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
378806016855	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806016856	Interdomain contacts; other site
378806016857	Cytokine receptor motif; other site
378806016858	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
378806016859	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
378806016860	putative active site [active]
378806016861	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
378806016862	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806016863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016864	active site
378806016865	phosphorylation site [posttranslational modification]
378806016866	intermolecular recognition site; other site
378806016867	dimerization interface [polypeptide binding]; other site
378806016868	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806016869	DNA binding site [nucleotide binding]
378806016870	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806016871	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806016872	dimerization interface [polypeptide binding]; other site
378806016873	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806016874	dimer interface [polypeptide binding]; other site
378806016875	phosphorylation site [posttranslational modification]
378806016876	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806016877	ATP binding site [chemical binding]; other site
378806016878	Mg2+ binding site [ion binding]; other site
378806016879	G-X-G motif; other site
378806016880	Plant protein of unknown function (DUF946); Region: DUF946; pfam06101
378806016881	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
378806016882	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
378806016883	dimer interface [polypeptide binding]; other site
378806016884	active site
378806016885	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
378806016886	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
378806016887	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
378806016888	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
378806016889	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
378806016890	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806016891	substrate binding site [chemical binding]; other site
378806016892	oxyanion hole (OAH) forming residues; other site
378806016893	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
378806016894	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
378806016895	active site
378806016896	Zn binding site [ion binding]; other site
378806016897	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
378806016898	Vault protein inter-alpha-trypsin domain; Region: VIT_2; pfam13757
378806016899	von Willebrand factor type A domain; Region: VWA_3; pfam13768
378806016900	metal ion-dependent adhesion site (MIDAS); other site
378806016901	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
378806016902	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
378806016903	DNA methylase; Region: N6_N4_Mtase; pfam01555
378806016904	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
378806016905	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806016906	active site
378806016907	metal binding site [ion binding]; metal-binding site
378806016908	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
378806016909	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
378806016910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806016911	S-adenosylmethionine binding site [chemical binding]; other site
378806016912	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806016913	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
378806016914	binding surface
378806016915	TPR motif; other site
378806016916	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
378806016917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016918	active site
378806016919	phosphorylation site [posttranslational modification]
378806016920	intermolecular recognition site; other site
378806016921	dimerization interface [polypeptide binding]; other site
378806016922	CheB methylesterase; Region: CheB_methylest; pfam01339
378806016923	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806016924	putative binding surface; other site
378806016925	active site
378806016926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806016927	ATP binding site [chemical binding]; other site
378806016928	Mg2+ binding site [ion binding]; other site
378806016929	G-X-G motif; other site
378806016930	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806016931	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806016932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016933	active site
378806016934	phosphorylation site [posttranslational modification]
378806016935	intermolecular recognition site; other site
378806016936	dimerization interface [polypeptide binding]; other site
378806016937	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806016938	dimerization interface [polypeptide binding]; other site
378806016939	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806016940	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806016941	dimer interface [polypeptide binding]; other site
378806016942	putative CheW interface [polypeptide binding]; other site
378806016943	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806016944	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806016945	dimer interface [polypeptide binding]; other site
378806016946	putative CheW interface [polypeptide binding]; other site
378806016947	CheW-like domain; Region: CheW; pfam01584
378806016948	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806016949	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806016950	ligand binding site [chemical binding]; other site
378806016951	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806016952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806016953	active site
378806016954	phosphorylation site [posttranslational modification]
378806016955	intermolecular recognition site; other site
378806016956	dimerization interface [polypeptide binding]; other site
378806016957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806016958	Walker A motif; other site
378806016959	ATP binding site [chemical binding]; other site
378806016960	Walker B motif; other site
378806016961	arginine finger; other site
378806016962	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806016963	Predicted membrane protein [Function unknown]; Region: COG2259
378806016964	Uncharacterized conserved protein [Function unknown]; Region: COG2135
378806016965	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806016966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806016967	dimer interface [polypeptide binding]; other site
378806016968	phosphorylation site [posttranslational modification]
378806016969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806016970	ATP binding site [chemical binding]; other site
378806016971	Mg2+ binding site [ion binding]; other site
378806016972	G-X-G motif; other site
378806016973	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806016974	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806016975	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806016976	calcium binding site 2 [ion binding]; other site
378806016977	active site
378806016978	catalytic triad [active]
378806016979	calcium binding site 1 [ion binding]; other site
378806016980	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806016981	ligand binding site [chemical binding]; other site
378806016982	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806016983	putative alpha-glucosidase; Provisional; Region: PRK10658
378806016984	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
378806016985	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
378806016986	trimer interface [polypeptide binding]; other site
378806016987	active site
378806016988	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
378806016989	catalytic site [active]
378806016990	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
378806016991	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806016992	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
378806016993	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
378806016994	putative catalytic site [active]
378806016995	putative phosphate binding site [ion binding]; other site
378806016996	active site
378806016997	metal binding site A [ion binding]; metal-binding site
378806016998	DNA binding site [nucleotide binding]
378806016999	putative AP binding site [nucleotide binding]; other site
378806017000	putative metal binding site B [ion binding]; other site
378806017001	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017002	TPR motif; other site
378806017003	binding surface
378806017004	TPR repeat; Region: TPR_11; pfam13414
378806017005	Transglycosylase; Region: Transgly; pfam00912
378806017006	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
378806017007	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
378806017008	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806017009	dimerization interface [polypeptide binding]; other site
378806017010	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806017011	dimer interface [polypeptide binding]; other site
378806017012	phosphorylation site [posttranslational modification]
378806017013	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806017014	ATP binding site [chemical binding]; other site
378806017015	Mg2+ binding site [ion binding]; other site
378806017016	G-X-G motif; other site
378806017017	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
378806017018	30S subunit binding site; other site
378806017019	Response regulator receiver domain; Region: Response_reg; pfam00072
378806017020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017021	active site
378806017022	phosphorylation site [posttranslational modification]
378806017023	intermolecular recognition site; other site
378806017024	dimerization interface [polypeptide binding]; other site
378806017025	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
378806017026	HEAT repeats; Region: HEAT_2; pfam13646
378806017027	HEAT repeats; Region: HEAT_2; pfam13646
378806017028	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
378806017029	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806017030	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806017031	ligand binding site [chemical binding]; other site
378806017032	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
378806017033	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
378806017034	Permutation of conserved domain; other site
378806017035	active site
378806017036	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
378806017037	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806017038	Thioredoxin; Region: Thioredoxin_4; pfam13462
378806017039	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
378806017040	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
378806017041	active site
378806017042	homodimer interface [polypeptide binding]; other site
378806017043	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806017044	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806017045	phosphopeptide binding site; other site
378806017046	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806017047	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806017048	metal binding site [ion binding]; metal-binding site
378806017049	active site
378806017050	I-site; other site
378806017051	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
378806017052	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
378806017053	Yqey-like protein; Region: YqeY; pfam09424
378806017054	DNA primase, catalytic core; Region: dnaG; TIGR01391
378806017055	CHC2 zinc finger; Region: zf-CHC2; pfam01807
378806017056	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
378806017057	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
378806017058	active site
378806017059	metal binding site [ion binding]; metal-binding site
378806017060	interdomain interaction site; other site
378806017061	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
378806017062	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
378806017063	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
378806017064	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
378806017065	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806017066	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
378806017067	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806017068	DNA binding residues [nucleotide binding]
378806017069	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
378806017070	DNA binding site [nucleotide binding]
378806017071	active site
378806017072	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806017073	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806017074	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017075	active site
378806017076	ATP binding site [chemical binding]; other site
378806017077	substrate binding site [chemical binding]; other site
378806017078	activation loop (A-loop); other site
378806017079	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017080	active site
378806017081	ATP binding site [chemical binding]; other site
378806017082	substrate binding site [chemical binding]; other site
378806017083	activation loop (A-loop); other site
378806017084	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806017085	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806017086	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806017087	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
378806017088	potential frameshift: common BLAST hit: gi|189501225|ref|YP_001960695.1| transposase family protein
378806017089	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
378806017090	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
378806017091	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
378806017092	putative metal binding site [ion binding]; other site
378806017093	TIR domain; Region: TIR_2; pfam13676
378806017094	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806017095	ssDNA binding protein; Region: Viral_DNA_bp; cl17757
378806017096	Domain of unknown function (DUF955); Region: DUF955; pfam06114
378806017097	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
378806017098	putative uracil binding site [chemical binding]; other site
378806017099	putative active site [active]
378806017100	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
378806017101	Phosphotransferase enzyme family; Region: APH; pfam01636
378806017102	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
378806017103	putative metal binding site [ion binding]; other site
378806017104	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
378806017105	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806017106	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
378806017107	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806017108	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806017109	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806017110	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806017111	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806017112	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806017113	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
378806017114	Helix-turn-helix domain; Region: HTH_17; pfam12728
378806017115	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806017116	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806017117	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017118	active site
378806017119	ATP binding site [chemical binding]; other site
378806017120	substrate binding site [chemical binding]; other site
378806017121	activation loop (A-loop); other site
378806017122	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017123	active site
378806017124	ATP binding site [chemical binding]; other site
378806017125	substrate binding site [chemical binding]; other site
378806017126	activation loop (A-loop); other site
378806017127	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806017128	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
378806017129	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
378806017130	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806017131	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
378806017132	active site clefts [active]
378806017133	zinc binding site [ion binding]; other site
378806017134	dimer interface [polypeptide binding]; other site
378806017135	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
378806017136	Sulfate transporter family; Region: Sulfate_transp; pfam00916
378806017137	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
378806017138	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806017139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017140	active site
378806017141	phosphorylation site [posttranslational modification]
378806017142	intermolecular recognition site; other site
378806017143	dimerization interface [polypeptide binding]; other site
378806017144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806017145	Walker A motif; other site
378806017146	ATP binding site [chemical binding]; other site
378806017147	Walker B motif; other site
378806017148	arginine finger; other site
378806017149	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806017150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806017151	dimer interface [polypeptide binding]; other site
378806017152	phosphorylation site [posttranslational modification]
378806017153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806017154	ATP binding site [chemical binding]; other site
378806017155	Mg2+ binding site [ion binding]; other site
378806017156	G-X-G motif; other site
378806017157	DDE superfamily endonuclease; Region: DDE_3; pfam13358
378806017158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
378806017159	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
378806017160	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806017161	Allene oxide cyclase; Region: Allene_ox_cyc; cl05704
378806017162	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806017163	active site
378806017164	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
378806017165	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
378806017166	conserved cys residue [active]
378806017167	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
378806017168	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
378806017169	conserved cys residue [active]
378806017170	Cellulose binding domain; Region: CBM_3; cl03026
378806017171	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
378806017172	beta-galactosidase; Region: BGL; TIGR03356
378806017173	Transcriptional regulators [Transcription]; Region: PurR; COG1609
378806017174	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
378806017175	DNA binding site [nucleotide binding]
378806017176	domain linker motif; other site
378806017177	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
378806017178	ligand binding site [chemical binding]; other site
378806017179	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
378806017180	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806017181	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806017182	catalytic residue [active]
378806017183	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
378806017184	Cupin domain; Region: Cupin_2; pfam07883
378806017185	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
378806017186	DNA-binding site [nucleotide binding]; DNA binding site
378806017187	RNA-binding motif; other site
378806017188	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
378806017189	dimer interface [polypeptide binding]; other site
378806017190	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806017191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017192	active site
378806017193	phosphorylation site [posttranslational modification]
378806017194	intermolecular recognition site; other site
378806017195	dimerization interface [polypeptide binding]; other site
378806017196	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806017197	DNA binding site [nucleotide binding]
378806017198	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806017199	dimerization interface [polypeptide binding]; other site
378806017200	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806017201	dimer interface [polypeptide binding]; other site
378806017202	phosphorylation site [posttranslational modification]
378806017203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806017204	ATP binding site [chemical binding]; other site
378806017205	Mg2+ binding site [ion binding]; other site
378806017206	G-X-G motif; other site
378806017207	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806017208	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
378806017209	UbiA prenyltransferase family; Region: UbiA; pfam01040
378806017210	TPR repeat; Region: TPR_11; pfam13414
378806017211	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017212	binding surface
378806017213	TPR motif; other site
378806017214	TPR repeat; Region: TPR_11; pfam13414
378806017215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017216	binding surface
378806017217	TPR motif; other site
378806017218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017219	binding surface
378806017220	TPR motif; other site
378806017221	TPR repeat; Region: TPR_11; pfam13414
378806017222	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017223	TPR motif; other site
378806017224	binding surface
378806017225	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806017226	TPR repeat; Region: TPR_11; pfam13414
378806017227	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
378806017228	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
378806017229	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
378806017230	nucleotide binding site [chemical binding]; other site
378806017231	putative NEF/HSP70 interaction site [polypeptide binding]; other site
378806017232	SBD interface [polypeptide binding]; other site
378806017233	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
378806017234	nucleotide binding site [chemical binding]; other site
378806017235	putative NEF/HSP70 interaction site [polypeptide binding]; other site
378806017236	SBD interface [polypeptide binding]; other site
378806017237	DNA-K related protein; Region: DUF3731; pfam12531
378806017238	Phytase; Region: Phytase; cl17685
378806017239	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
378806017240	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
378806017241	NADP-binding site; other site
378806017242	homotetramer interface [polypeptide binding]; other site
378806017243	substrate binding site [chemical binding]; other site
378806017244	homodimer interface [polypeptide binding]; other site
378806017245	active site
378806017246	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806017247	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
378806017248	NADP-binding site; other site
378806017249	homotetramer interface [polypeptide binding]; other site
378806017250	substrate binding site [chemical binding]; other site
378806017251	homodimer interface [polypeptide binding]; other site
378806017252	active site
378806017253	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806017254	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806017255	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806017256	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806017257	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762
378806017258	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
378806017259	active site residue [active]
378806017260	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
378806017261	ATP binding site [chemical binding]; other site
378806017262	substrate interface [chemical binding]; other site
378806017263	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806017264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806017265	S-adenosylmethionine binding site [chemical binding]; other site
378806017266	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567
378806017267	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
378806017268	FAD binding pocket [chemical binding]; other site
378806017269	FAD binding motif [chemical binding]; other site
378806017270	phosphate binding motif [ion binding]; other site
378806017271	beta-alpha-beta structure motif; other site
378806017272	NAD binding pocket [chemical binding]; other site
378806017273	Iron coordination center [ion binding]; other site
378806017274	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
378806017275	catalytic core [active]
378806017276	Response regulator receiver domain; Region: Response_reg; pfam00072
378806017277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017278	active site
378806017279	phosphorylation site [posttranslational modification]
378806017280	intermolecular recognition site; other site
378806017281	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806017282	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806017283	metal binding site [ion binding]; metal-binding site
378806017284	active site
378806017285	I-site; other site
378806017286	ribosome recycling factor; Reviewed; Region: frr; PRK00083
378806017287	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
378806017288	hinge region; other site
378806017289	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
378806017290	putative nucleotide binding site [chemical binding]; other site
378806017291	uridine monophosphate binding site [chemical binding]; other site
378806017292	homohexameric interface [polypeptide binding]; other site
378806017293	elongation factor Ts; Reviewed; Region: tsf; PRK12332
378806017294	UBA/TS-N domain; Region: UBA; pfam00627
378806017295	Elongation factor TS; Region: EF_TS; pfam00889
378806017296	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
378806017297	rRNA interaction site [nucleotide binding]; other site
378806017298	S8 interaction site; other site
378806017299	putative laminin-1 binding site; other site
378806017300	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
378806017301	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
378806017302	SEC-C motif; Region: SEC-C; pfam02810
378806017303	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
378806017304	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
378806017305	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806017306	metal binding site [ion binding]; metal-binding site
378806017307	active site
378806017308	I-site; other site
378806017309	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
378806017310	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
378806017311	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806017312	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
378806017313	active site
378806017314	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
378806017315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806017316	Walker A/P-loop; other site
378806017317	ATP binding site [chemical binding]; other site
378806017318	Q-loop/lid; other site
378806017319	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
378806017320	ABC transporter signature motif; other site
378806017321	Walker B; other site
378806017322	D-loop; other site
378806017323	H-loop/switch region; other site
378806017324	SWIM zinc finger; Region: SWIM; pfam04434
378806017325	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
378806017326	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
378806017327	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806017328	ATP binding site [chemical binding]; other site
378806017329	putative Mg++ binding site [ion binding]; other site
378806017330	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806017331	nucleotide binding region [chemical binding]; other site
378806017332	ATP-binding site [chemical binding]; other site
378806017333	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
378806017334	active site
378806017335	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806017336	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
378806017337	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
378806017338	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
378806017339	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
378806017340	threonine synthase; Validated; Region: PRK08197
378806017341	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
378806017342	homodimer interface [polypeptide binding]; other site
378806017343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806017344	catalytic residue [active]
378806017345	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
378806017346	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
378806017347	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806017348	Walker A/P-loop; other site
378806017349	ATP binding site [chemical binding]; other site
378806017350	Q-loop/lid; other site
378806017351	ABC transporter signature motif; other site
378806017352	Walker B; other site
378806017353	D-loop; other site
378806017354	H-loop/switch region; other site
378806017355	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
378806017356	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
378806017357	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
378806017358	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
378806017359	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806017360	active site
378806017361	metal binding site [ion binding]; metal-binding site
378806017362	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
378806017363	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
378806017364	Uncharacterized conserved protein [Function unknown]; Region: COG1434
378806017365	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
378806017366	putative active site [active]
378806017367	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806017368	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017369	active site
378806017370	ATP binding site [chemical binding]; other site
378806017371	substrate binding site [chemical binding]; other site
378806017372	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806017373	substrate binding site [chemical binding]; other site
378806017374	activation loop (A-loop); other site
378806017375	activation loop (A-loop); other site
378806017376	PEGA domain; Region: PEGA; pfam08308
378806017377	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017378	TPR motif; other site
378806017379	TPR repeat; Region: TPR_11; pfam13414
378806017380	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
378806017381	ATP-NAD kinase; Region: NAD_kinase; pfam01513
378806017382	recombination factor protein RarA; Reviewed; Region: PRK13342
378806017383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806017384	Walker A motif; other site
378806017385	ATP binding site [chemical binding]; other site
378806017386	Walker B motif; other site
378806017387	arginine finger; other site
378806017388	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
378806017389	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806017390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017391	active site
378806017392	phosphorylation site [posttranslational modification]
378806017393	intermolecular recognition site; other site
378806017394	dimerization interface [polypeptide binding]; other site
378806017395	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806017396	Walker A motif; other site
378806017397	ATP binding site [chemical binding]; other site
378806017398	Walker B motif; other site
378806017399	arginine finger; other site
378806017400	Response regulator receiver domain; Region: Response_reg; pfam00072
378806017401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017402	active site
378806017403	phosphorylation site [posttranslational modification]
378806017404	intermolecular recognition site; other site
378806017405	dimerization interface [polypeptide binding]; other site
378806017406	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806017407	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806017408	dimer interface [polypeptide binding]; other site
378806017409	phosphorylation site [posttranslational modification]
378806017410	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806017411	ATP binding site [chemical binding]; other site
378806017412	G-X-G motif; other site
378806017413	Response regulator receiver domain; Region: Response_reg; pfam00072
378806017414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017415	active site
378806017416	phosphorylation site [posttranslational modification]
378806017417	intermolecular recognition site; other site
378806017418	dimerization interface [polypeptide binding]; other site
378806017419	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806017420	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806017421	metal binding site [ion binding]; metal-binding site
378806017422	active site
378806017423	I-site; other site
378806017424	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
378806017425	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
378806017426	Ligand binding site; other site
378806017427	Putative Catalytic site; other site
378806017428	DXD motif; other site
378806017429	Escherichia coli YdjC-like family of  proteins; Region: YdjC; cd10808
378806017430	putative active site [active]
378806017431	YdjC motif; other site
378806017432	Mg binding site [ion binding]; other site
378806017433	putative homodimer interface [polypeptide binding]; other site
378806017434	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
378806017435	Cache domain; Region: Cache_1; pfam02743
378806017436	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806017437	HAMP domain; Region: HAMP; pfam00672
378806017438	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806017439	dimer interface [polypeptide binding]; other site
378806017440	phosphorylation site [posttranslational modification]
378806017441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806017442	ATP binding site [chemical binding]; other site
378806017443	Mg2+ binding site [ion binding]; other site
378806017444	G-X-G motif; other site
378806017445	Response regulator receiver domain; Region: Response_reg; pfam00072
378806017446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017447	active site
378806017448	phosphorylation site [posttranslational modification]
378806017449	intermolecular recognition site; other site
378806017450	dimerization interface [polypeptide binding]; other site
378806017451	Response regulator receiver domain; Region: Response_reg; pfam00072
378806017452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017453	active site
378806017454	phosphorylation site [posttranslational modification]
378806017455	intermolecular recognition site; other site
378806017456	dimerization interface [polypeptide binding]; other site
378806017457	Hpt domain; Region: Hpt; pfam01627
378806017458	putative binding surface; other site
378806017459	active site
378806017460	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
378806017461	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
378806017462	ligand binding site [chemical binding]; other site
378806017463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017464	active site
378806017465	phosphorylation site [posttranslational modification]
378806017466	intermolecular recognition site; other site
378806017467	dimerization interface [polypeptide binding]; other site
378806017468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806017469	ATP binding site [chemical binding]; other site
378806017470	Mg2+ binding site [ion binding]; other site
378806017471	G-X-G motif; other site
378806017472	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806017473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806017474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806017475	S-adenosylmethionine binding site [chemical binding]; other site
378806017476	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
378806017477	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806017478	substrate binding site [chemical binding]; other site
378806017479	oxyanion hole (OAH) forming residues; other site
378806017480	trimer interface [polypeptide binding]; other site
378806017481	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
378806017482	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
378806017483	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
378806017484	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
378806017485	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
378806017486	dimer interface [polypeptide binding]; other site
378806017487	active site
378806017488	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
378806017489	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
378806017490	substrate binding site [chemical binding]; other site
378806017491	active site
378806017492	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
378806017493	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
378806017494	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
378806017495	active site
378806017496	catalytic site [active]
378806017497	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
378806017498	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
378806017499	active site
378806017500	catalytic residues [active]
378806017501	DNA binding site [nucleotide binding]
378806017502	Int/Topo IB signature motif; other site
378806017503	Helix-turn-helix domain; Region: HTH_17; pfam12728
378806017504	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
378806017505	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
378806017506	tetramer interface [polypeptide binding]; other site
378806017507	active site
378806017508	Mg2+/Mn2+ binding site [ion binding]; other site
378806017509	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
378806017510	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806017511	acyl-activating enzyme (AAE) consensus motif; other site
378806017512	AMP binding site [chemical binding]; other site
378806017513	active site
378806017514	CoA binding site [chemical binding]; other site
378806017515	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
378806017516	Amidohydrolase; Region: Amidohydro_2; pfam04909
378806017517	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
378806017518	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
378806017519	acyl-activating enzyme (AAE) consensus motif; other site
378806017520	active site
378806017521	AMP binding site [chemical binding]; other site
378806017522	CoA binding site [chemical binding]; other site
378806017523	3-dehydroquinate synthase; Provisional; Region: PRK02290
378806017524	Class I aldolases; Region: Aldolase_Class_I; cl17187
378806017525	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
378806017526	catalytic residue [active]
378806017527	aspartate kinase; Reviewed; Region: PRK06635
378806017528	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
378806017529	putative nucleotide binding site [chemical binding]; other site
378806017530	putative catalytic residues [active]
378806017531	putative Mg ion binding site [ion binding]; other site
378806017532	putative aspartate binding site [chemical binding]; other site
378806017533	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
378806017534	putative allosteric regulatory site; other site
378806017535	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
378806017536	putative allosteric regulatory residue; other site
378806017537	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
378806017538	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
378806017539	Multicopper oxidase; Region: Cu-oxidase; pfam00394
378806017540	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
378806017541	Transferase family; Region: Transferase; pfam02458
378806017542	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806017543	Cytochrome P450; Region: p450; cl12078
378806017544	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806017545	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
378806017546	Di-iron ligands [ion binding]; other site
378806017547	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
378806017548	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
378806017549	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806017550	Di-iron ligands [ion binding]; other site
378806017551	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
378806017552	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806017553	acyl-CoA synthetase; Validated; Region: PRK05850
378806017554	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806017555	acyl-activating enzyme (AAE) consensus motif; other site
378806017556	active site
378806017557	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
378806017558	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806017559	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806017560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806017561	Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226
378806017562	putative active site [active]
378806017563	Zn binding site [ion binding]; other site
378806017564	FOG: PKD repeat [General function prediction only]; Region: COG3291
378806017565	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
378806017566	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806017567	Predicted transcriptional regulator [Transcription]; Region: COG2944
378806017568	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806017569	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806017570	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806017571	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806017572	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806017573	DDE superfamily endonuclease; Region: DDE_5; cl17874
378806017574	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806017575	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806017576	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806017577	Uncharacterized conserved protein [Function unknown]; Region: COG3791
378806017578	Methyltransferase domain; Region: Methyltransf_31; pfam13847
378806017579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806017580	S-adenosylmethionine binding site [chemical binding]; other site
378806017581	short chain dehydrogenase; Provisional; Region: PRK06179
378806017582	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
378806017583	NADP binding site [chemical binding]; other site
378806017584	active site
378806017585	steroid binding site; other site
378806017586	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806017587	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806017588	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
378806017589	dimerization interface [polypeptide binding]; other site
378806017590	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
378806017591	ATP binding site [chemical binding]; other site
378806017592	putative Mg++ binding site [ion binding]; other site
378806017593	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806017594	nucleotide binding region [chemical binding]; other site
378806017595	ATP-binding site [chemical binding]; other site
378806017596	putative oxidoreductase; Provisional; Region: PRK11579
378806017597	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806017598	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
378806017599	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
378806017600	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
378806017601	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
378806017602	putative substrate binding site [chemical binding]; other site
378806017603	active site
378806017604	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
378806017605	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
378806017606	substrate binding site [chemical binding]; other site
378806017607	active site
378806017608	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
378806017609	putative metal binding site [ion binding]; other site
378806017610	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576
378806017611	putative ligand binding site [chemical binding]; other site
378806017612	putative catalytic site [active]
378806017613	Uncharacterized conserved protein [Function unknown]; Region: COG3791
378806017614	Transposase; Region: DEDD_Tnp_IS110; pfam01548
378806017615	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
378806017616	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
378806017617	VanW like protein; Region: VanW; pfam04294
378806017618	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
378806017619	putative dimer interface [polypeptide binding]; other site
378806017620	catalytic triad [active]
378806017621	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
378806017622	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
378806017623	His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977
378806017624	His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978
378806017625	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806017626	FeS/SAM binding site; other site
378806017627	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
378806017628	His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976
378806017629	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
378806017630	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806017631	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
378806017632	putative NAD(P) binding site [chemical binding]; other site
378806017633	active site
378806017634	transcriptional activator TtdR; Provisional; Region: PRK09801
378806017635	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806017636	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
378806017637	putative effector binding pocket; other site
378806017638	dimerization interface [polypeptide binding]; other site
378806017639	classical (c) SDRs; Region: SDR_c; cd05233
378806017640	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806017641	NAD(P) binding site [chemical binding]; other site
378806017642	active site
378806017643	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806017644	DNA-binding site [nucleotide binding]; DNA binding site
378806017645	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
378806017646	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806017647	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806017648	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
378806017649	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017650	active site
378806017651	ATP binding site [chemical binding]; other site
378806017652	substrate binding site [chemical binding]; other site
378806017653	activation loop (A-loop); other site
378806017654	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806017655	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017656	active site
378806017657	ATP binding site [chemical binding]; other site
378806017658	substrate binding site [chemical binding]; other site
378806017659	activation loop (A-loop); other site
378806017660	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806017661	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806017662	Phage capsid family; Region: Phage_capsid; pfam05065
378806017663	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806017664	TIR domain; Region: TIR_2; pfam13676
378806017665	Virulence-associated protein E; Region: VirE; pfam05272
378806017666	Helix-turn-helix domain; Region: HTH_17; pfam12728
378806017667	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806017668	active site
378806017669	DNA binding site [nucleotide binding]
378806017670	Int/Topo IB signature motif; other site
378806017671	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806017672	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806017673	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806017674	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806017675	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806017676	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806017677	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806017678	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806017679	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806017680	calcium binding site 2 [ion binding]; other site
378806017681	active site
378806017682	catalytic triad [active]
378806017683	calcium binding site 1 [ion binding]; other site
378806017684	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
378806017685	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806017686	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806017687	ligand binding site [chemical binding]; other site
378806017688	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
378806017689	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806017690	catalytic residues [active]
378806017691	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806017692	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
378806017693	protein binding site [polypeptide binding]; other site
378806017694	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
378806017695	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
378806017696	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
378806017697	ATP binding site [chemical binding]; other site
378806017698	active site
378806017699	substrate binding site [chemical binding]; other site
378806017700	adenylosuccinate lyase; Provisional; Region: PRK07492
378806017701	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
378806017702	tetramer interface [polypeptide binding]; other site
378806017703	active site
378806017704	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806017705	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017706	active site
378806017707	ATP binding site [chemical binding]; other site
378806017708	substrate binding site [chemical binding]; other site
378806017709	activation loop (A-loop); other site
378806017710	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
378806017711	Uncharacterized conserved protein [Function unknown]; Region: COG1262
378806017712	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
378806017713	trimer interface [polypeptide binding]; other site
378806017714	active site
378806017715	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
378806017716	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806017717	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
378806017718	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
378806017719	RNase E interface [polypeptide binding]; other site
378806017720	trimer interface [polypeptide binding]; other site
378806017721	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
378806017722	RNase E interface [polypeptide binding]; other site
378806017723	trimer interface [polypeptide binding]; other site
378806017724	active site
378806017725	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
378806017726	putative nucleic acid binding region [nucleotide binding]; other site
378806017727	G-X-X-G motif; other site
378806017728	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
378806017729	RNA binding site [nucleotide binding]; other site
378806017730	domain interface; other site
378806017731	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
378806017732	16S/18S rRNA binding site [nucleotide binding]; other site
378806017733	S13e-L30e interaction site [polypeptide binding]; other site
378806017734	25S rRNA binding site [nucleotide binding]; other site
378806017735	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
378806017736	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
378806017737	RNA binding site [nucleotide binding]; other site
378806017738	active site
378806017739	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
378806017740	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
378806017741	Protein of unknown function (DUF503); Region: DUF503; pfam04456
378806017742	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
378806017743	translation initiation factor IF-2; Validated; Region: infB; PRK05306
378806017744	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
378806017745	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
378806017746	G1 box; other site
378806017747	putative GEF interaction site [polypeptide binding]; other site
378806017748	GTP/Mg2+ binding site [chemical binding]; other site
378806017749	Switch I region; other site
378806017750	G2 box; other site
378806017751	G3 box; other site
378806017752	Switch II region; other site
378806017753	G4 box; other site
378806017754	G5 box; other site
378806017755	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
378806017756	Translation-initiation factor 2; Region: IF-2; pfam11987
378806017757	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
378806017758	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
378806017759	putative RNA binding cleft [nucleotide binding]; other site
378806017760	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
378806017761	NusA N-terminal domain; Region: NusA_N; pfam08529
378806017762	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
378806017763	RNA binding site [nucleotide binding]; other site
378806017764	homodimer interface [polypeptide binding]; other site
378806017765	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
378806017766	G-X-X-G motif; other site
378806017767	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
378806017768	G-X-X-G motif; other site
378806017769	ribosome maturation protein RimP; Reviewed; Region: PRK00092
378806017770	hypothetical protein; Provisional; Region: PRK14641
378806017771	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
378806017772	putative oligomer interface [polypeptide binding]; other site
378806017773	putative RNA binding site [nucleotide binding]; other site
378806017774	nitrilase; Region: PLN02798
378806017775	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
378806017776	putative active site [active]
378806017777	catalytic triad [active]
378806017778	dimer interface [polypeptide binding]; other site
378806017779	FecR protein; Region: FecR; pfam04773
378806017780	LysM domain; Region: LysM; pfam01476
378806017781	Cache domain; Region: Cache_1; pfam02743
378806017782	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806017783	dimerization interface [polypeptide binding]; other site
378806017784	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
378806017785	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806017786	Zn2+ binding site [ion binding]; other site
378806017787	Mg2+ binding site [ion binding]; other site
378806017788	Protein of unknown function (DUF971); Region: DUF971; pfam06155
378806017789	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806017790	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017791	active site
378806017792	ATP binding site [chemical binding]; other site
378806017793	substrate binding site [chemical binding]; other site
378806017794	activation loop (A-loop); other site
378806017795	PEGA domain; Region: PEGA; pfam08308
378806017796	Stringent starvation protein B; Region: SspB; cl01120
378806017797	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
378806017798	SmpB-tmRNA interface; other site
378806017799	Pantoate-beta-alanine ligase; Region: PanC; cd00560
378806017800	pantoate--beta-alanine ligase; Region: panC; TIGR00018
378806017801	active site
378806017802	ATP-binding site [chemical binding]; other site
378806017803	pantoate-binding site; other site
378806017804	HXXH motif; other site
378806017805	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
378806017806	oligomerization interface [polypeptide binding]; other site
378806017807	active site
378806017808	metal binding site [ion binding]; metal-binding site
378806017809	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
378806017810	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
378806017811	Substrate-binding site [chemical binding]; other site
378806017812	Substrate specificity [chemical binding]; other site
378806017813	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
378806017814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806017815	S-adenosylmethionine binding site [chemical binding]; other site
378806017816	UGMP family protein; Validated; Region: PRK09604
378806017817	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
378806017818	Response regulator receiver domain; Region: Response_reg; pfam00072
378806017819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017820	active site
378806017821	phosphorylation site [posttranslational modification]
378806017822	intermolecular recognition site; other site
378806017823	dimerization interface [polypeptide binding]; other site
378806017824	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
378806017825	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017826	binding surface
378806017827	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806017828	TPR motif; other site
378806017829	TPR repeat; Region: TPR_11; pfam13414
378806017830	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806017831	HSP70 interaction site [polypeptide binding]; other site
378806017832	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017833	binding surface
378806017834	TPR motif; other site
378806017835	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
378806017836	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
378806017837	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
378806017838	Protein phosphatase 2C; Region: PP2C; pfam00481
378806017839	active site
378806017840	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
378806017841	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
378806017842	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
378806017843	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
378806017844	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
378806017845	Substrate binding site; other site
378806017846	metal-binding site
378806017847	Phosphotransferase enzyme family; Region: APH; pfam01636
378806017848	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
378806017849	substrate binding site [chemical binding]; other site
378806017850	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
378806017851	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
378806017852	dimer interface [polypeptide binding]; other site
378806017853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806017854	catalytic residue [active]
378806017855	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
378806017856	Protein kinase domain; Region: Pkinase; pfam00069
378806017857	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806017858	active site
378806017859	ATP binding site [chemical binding]; other site
378806017860	substrate binding site [chemical binding]; other site
378806017861	activation loop (A-loop); other site
378806017862	Family description; Region: VCBS; pfam13517
378806017863	Family description; Region: VCBS; pfam13517
378806017864	Family description; Region: VCBS; pfam13517
378806017865	FG-GAP repeat; Region: FG-GAP; pfam01839
378806017866	Family description; Region: VCBS; pfam13517
378806017867	Family description; Region: VCBS; pfam13517
378806017868	Family description; Region: VCBS; pfam13517
378806017869	Family description; Region: VCBS; pfam13517
378806017870	Family description; Region: VCBS; pfam13517
378806017871	Family description; Region: VCBS; pfam13517
378806017872	Family description; Region: VCBS; pfam13517
378806017873	Family description; Region: VCBS; pfam13517
378806017874	Family description; Region: VCBS; pfam13517
378806017875	Family description; Region: VCBS; pfam13517
378806017876	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
378806017877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806017878	S-adenosylmethionine binding site [chemical binding]; other site
378806017879	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
378806017880	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
378806017881	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
378806017882	putative RNA binding site [nucleotide binding]; other site
378806017883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806017884	S-adenosylmethionine binding site [chemical binding]; other site
378806017885	Flagellin N-methylase; Region: FliB; cl00497
378806017886	glycerate kinase; Region: TIGR00045
378806017887	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
378806017888	catalytic triad [active]
378806017889	conserved cis-peptide bond; other site
378806017890	nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484
378806017891	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
378806017892	active site
378806017893	CBD_II domain; Region: CBD_II; smart00637
378806017894	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
378806017895	Interdomain contacts; other site
378806017896	Cytokine receptor motif; other site
378806017897	Glyco_18 domain; Region: Glyco_18; smart00636
378806017898	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
378806017899	active site
378806017900	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
378806017901	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
378806017902	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
378806017903	dimer interface [polypeptide binding]; other site
378806017904	substrate binding site [chemical binding]; other site
378806017905	metal binding sites [ion binding]; metal-binding site
378806017906	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
378806017907	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
378806017908	motif 1; other site
378806017909	dimer interface [polypeptide binding]; other site
378806017910	active site
378806017911	motif 2; other site
378806017912	motif 3; other site
378806017913	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806017914	Zn binding site [ion binding]; other site
378806017915	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
378806017916	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806017917	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806017918	calcium binding site 2 [ion binding]; other site
378806017919	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806017920	active site
378806017921	catalytic triad [active]
378806017922	calcium binding site 1 [ion binding]; other site
378806017923	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
378806017924	Short C-terminal domain; Region: SHOCT; pfam09851
378806017925	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
378806017926	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
378806017927	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
378806017928	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806017929	Walker A/P-loop; other site
378806017930	ATP binding site [chemical binding]; other site
378806017931	Q-loop/lid; other site
378806017932	ABC transporter signature motif; other site
378806017933	Walker B; other site
378806017934	D-loop; other site
378806017935	H-loop/switch region; other site
378806017936	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
378806017937	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
378806017938	Rhomboid family; Region: Rhomboid; pfam01694
378806017939	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017940	TPR motif; other site
378806017941	binding surface
378806017942	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806017943	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806017944	phosphopeptide binding site; other site
378806017945	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806017946	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806017947	phosphopeptide binding site; other site
378806017948	TPR repeat; Region: TPR_11; pfam13414
378806017949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806017950	TPR motif; other site
378806017951	Response regulator receiver domain; Region: Response_reg; pfam00072
378806017952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806017953	active site
378806017954	phosphorylation site [posttranslational modification]
378806017955	intermolecular recognition site; other site
378806017956	dimerization interface [polypeptide binding]; other site
378806017957	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
378806017958	non-specific DNA binding site [nucleotide binding]; other site
378806017959	salt bridge; other site
378806017960	sequence-specific DNA binding site [nucleotide binding]; other site
378806017961	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
378806017962	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806017963	substrate binding site [chemical binding]; other site
378806017964	oxyanion hole (OAH) forming residues; other site
378806017965	trimer interface [polypeptide binding]; other site
378806017966	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
378806017967	carboxyltransferase (CT) interaction site; other site
378806017968	biotinylation site [posttranslational modification]; other site
378806017969	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
378806017970	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
378806017971	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806017972	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
378806017973	cell division protein FtsZ; Validated; Region: PRK09330
378806017974	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
378806017975	nucleotide binding site [chemical binding]; other site
378806017976	SulA interaction site; other site
378806017977	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806017978	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806017979	ligand binding site [chemical binding]; other site
378806017980	cell division protein FtsA; Region: ftsA; TIGR01174
378806017981	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
378806017982	nucleotide binding site [chemical binding]; other site
378806017983	Cell division protein FtsA; Region: FtsA; pfam14450
378806017984	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
378806017985	Cell division protein FtsQ; Region: FtsQ; pfam03799
378806017986	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
378806017987	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
378806017988	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806017989	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652
378806017990	FAD binding domain; Region: FAD_binding_4; pfam01565
378806017991	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
378806017992	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
378806017993	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
378806017994	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
378806017995	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
378806017996	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
378806017997	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
378806017998	active site
378806017999	homodimer interface [polypeptide binding]; other site
378806018000	cell division protein FtsW; Region: ftsW; TIGR02614
378806018001	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
378806018002	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
378806018003	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
378806018004	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
378806018005	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
378806018006	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
378806018007	Mg++ binding site [ion binding]; other site
378806018008	putative catalytic motif [active]
378806018009	putative substrate binding site [chemical binding]; other site
378806018010	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
378806018011	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
378806018012	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
378806018013	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
378806018014	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
378806018015	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
378806018016	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
378806018017	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
378806018018	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
378806018019	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
378806018020	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
378806018021	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
378806018022	Cell division protein FtsL; Region: FtsL; pfam04999
378806018023	MraW methylase family; Region: Methyltransf_5; cl17771
378806018024	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
378806018025	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
378806018026	anti sigma factor interaction site; other site
378806018027	regulatory phosphorylation site [posttranslational modification]; other site
378806018028	cell division protein MraZ; Reviewed; Region: PRK00326
378806018029	MraZ protein; Region: MraZ; pfam02381
378806018030	MraZ protein; Region: MraZ; pfam02381
378806018031	PilZ domain; Region: PilZ; cl01260
378806018032	PilZ domain; Region: PilZ; pfam07238
378806018033	Uncharacterized conserved protein [Function unknown]; Region: COG4850
378806018034	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
378806018035	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
378806018036	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349
378806018037	active site
378806018038	Zn binding site [ion binding]; other site
378806018039	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
378806018040	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
378806018041	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
378806018042	homotetramer interface [polypeptide binding]; other site
378806018043	ligand binding site [chemical binding]; other site
378806018044	catalytic site [active]
378806018045	NAD binding site [chemical binding]; other site
378806018046	Peptidase M35 domain of peptidyl-Lys metalloendopeptidases; Region: M35_peptidyl-Lys; cd11306
378806018047	active site
378806018048	Zn binding site [ion binding]; other site
378806018049	Peptidase M35 domain of peptidyl-Lys metalloendopeptidases; Region: M35_peptidyl-Lys; cd11306
378806018050	active site
378806018051	Zn binding site [ion binding]; other site
378806018052	Gryzun, putative trafficking through Golgi; Region: Gryzun; pfam07919
378806018053	Protein kinase domain; Region: Pkinase; pfam00069
378806018054	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806018055	active site
378806018056	ATP binding site [chemical binding]; other site
378806018057	substrate binding site [chemical binding]; other site
378806018058	activation loop (A-loop); other site
378806018059	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
378806018060	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806018061	dimerization interface [polypeptide binding]; other site
378806018062	putative DNA binding site [nucleotide binding]; other site
378806018063	putative Zn2+ binding site [ion binding]; other site
378806018064	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
378806018065	putative hydrophobic ligand binding site [chemical binding]; other site
378806018066	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
378806018067	repeat-companion domain TIGR02996; Region: rpt_mate_G_obs
378806018068	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
378806018069	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806018070	FeS/SAM binding site; other site
378806018071	coproporphyrinogen III oxidase; Validated; Region: PRK08208
378806018072	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806018073	FeS/SAM binding site; other site
378806018074	HemN C-terminal domain; Region: HemN_C; pfam06969
378806018075	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
378806018076	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
378806018077	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806018078	motif II; other site
378806018079	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
378806018080	cleavage site
378806018081	active site
378806018082	Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282
378806018083	Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282
378806018084	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
378806018085	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
378806018086	conserved cys residue [active]
378806018087	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806018088	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
378806018089	Isochorismatase family; Region: Isochorismatase; pfam00857
378806018090	catalytic triad [active]
378806018091	conserved cis-peptide bond; other site
378806018092	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
378806018093	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
378806018094	putative active site [active]
378806018095	metal binding site [ion binding]; metal-binding site
378806018096	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
378806018097	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
378806018098	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
378806018099	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
378806018100	catalytic triad [active]
378806018101	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
378806018102	Domain of unknown function DUF20; Region: UPF0118; pfam01594
378806018103	transcription termination factor Rho; Provisional; Region: rho; PRK09376
378806018104	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
378806018105	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
378806018106	RNA binding site [nucleotide binding]; other site
378806018107	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
378806018108	multimer interface [polypeptide binding]; other site
378806018109	Walker A motif; other site
378806018110	ATP binding site [chemical binding]; other site
378806018111	Walker B motif; other site
378806018112	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
378806018113	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
378806018114	nucleotide binding pocket [chemical binding]; other site
378806018115	K-X-D-G motif; other site
378806018116	catalytic site [active]
378806018117	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
378806018118	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
378806018119	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
378806018120	Dimer interface [polypeptide binding]; other site
378806018121	BRCT sequence motif; other site
378806018122	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
378806018123	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
378806018124	RNA binding site [nucleotide binding]; other site
378806018125	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
378806018126	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
378806018127	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
378806018128	Transcriptional regulator; Region: Rrf2; cl17282
378806018129	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
378806018130	IHF dimer interface [polypeptide binding]; other site
378806018131	IHF - DNA interface [nucleotide binding]; other site
378806018132	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
378806018133	FHIPEP family; Region: FHIPEP; pfam00771
378806018134	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
378806018135	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
378806018136	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
378806018137	Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313
378806018138	FliP family; Region: FliP; cl00593
378806018139	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
378806018140	flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397
378806018141	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
378806018142	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
378806018143	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
378806018144	PilZ domain; Region: PilZ; pfam07238
378806018145	Response regulator receiver domain; Region: Response_reg; pfam00072
378806018146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806018147	active site
378806018148	phosphorylation site [posttranslational modification]
378806018149	intermolecular recognition site; other site
378806018150	dimerization interface [polypeptide binding]; other site
378806018151	TPR repeat; Region: TPR_11; pfam13414
378806018152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018153	binding surface
378806018154	TPR motif; other site
378806018155	Oxygen tolerance; Region: BatD; pfam13584
378806018156	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018157	TPR motif; other site
378806018158	binding surface
378806018159	TPR repeat; Region: TPR_11; pfam13414
378806018160	von Willebrand factor type A domain; Region: VWA_2; pfam13519
378806018161	metal ion-dependent adhesion site (MIDAS); other site
378806018162	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
378806018163	metal ion-dependent adhesion site (MIDAS); other site
378806018164	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
378806018165	Protein of unknown function DUF58; Region: DUF58; pfam01882
378806018166	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
378806018167	metal ion-dependent adhesion site (MIDAS); other site
378806018168	MoxR-like ATPases [General function prediction only]; Region: COG0714
378806018169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806018170	Walker A motif; other site
378806018171	ATP binding site [chemical binding]; other site
378806018172	Walker B motif; other site
378806018173	arginine finger; other site
378806018174	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806018175	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
378806018176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806018177	Methyltransferase domain; Region: Methyltransf_31; pfam13847
378806018178	S-adenosylmethionine binding site [chemical binding]; other site
378806018179	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806018180	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806018181	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806018182	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
378806018183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
378806018184	uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722
378806018185	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
378806018186	Mechanosensitive ion channel; Region: MS_channel; pfam00924
378806018187	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806018188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806018189	active site
378806018190	phosphorylation site [posttranslational modification]
378806018191	intermolecular recognition site; other site
378806018192	dimerization interface [polypeptide binding]; other site
378806018193	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806018194	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806018195	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
378806018196	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
378806018197	heme-binding residues [chemical binding]; other site
378806018198	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
378806018199	N-acetyl-D-glucosamine binding site [chemical binding]; other site
378806018200	catalytic residue [active]
378806018201	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806018202	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806018203	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806018204	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
378806018205	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806018206	Walker A motif; other site
378806018207	ATP binding site [chemical binding]; other site
378806018208	Walker B motif; other site
378806018209	arginine finger; other site
378806018210	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806018211	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806018212	active site
378806018213	ATP binding site [chemical binding]; other site
378806018214	substrate binding site [chemical binding]; other site
378806018215	activation loop (A-loop); other site
378806018216	PEGA domain; Region: PEGA; pfam08308
378806018217	FtsX-like permease family; Region: FtsX; pfam02687
378806018218	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
378806018219	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
378806018220	Walker A/P-loop; other site
378806018221	ATP binding site [chemical binding]; other site
378806018222	Q-loop/lid; other site
378806018223	ABC transporter signature motif; other site
378806018224	Walker B; other site
378806018225	D-loop; other site
378806018226	H-loop/switch region; other site
378806018227	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
378806018228	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
378806018229	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
378806018230	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
378806018231	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
378806018232	active site
378806018233	putative substrate binding pocket [chemical binding]; other site
378806018234	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
378806018235	active site
378806018236	catalytic motif [active]
378806018237	Zn binding site [ion binding]; other site
378806018238	PilZ domain; Region: PilZ; cl01260
378806018239	purine nucleoside phosphorylase; Provisional; Region: PRK08202
378806018240	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
378806018241	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
378806018242	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
378806018243	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
378806018244	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
378806018245	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
378806018246	ligand binding site [chemical binding]; other site
378806018247	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
378806018248	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
378806018249	Walker A/P-loop; other site
378806018250	ATP binding site [chemical binding]; other site
378806018251	Q-loop/lid; other site
378806018252	ABC transporter signature motif; other site
378806018253	Walker B; other site
378806018254	D-loop; other site
378806018255	H-loop/switch region; other site
378806018256	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
378806018257	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
378806018258	TM-ABC transporter signature motif; other site
378806018259	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806018260	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
378806018261	TM-ABC transporter signature motif; other site
378806018262	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
378806018263	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
378806018264	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
378806018265	active site
378806018266	substrate binding site [chemical binding]; other site
378806018267	metal binding site [ion binding]; metal-binding site
378806018268	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
378806018269	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
378806018270	intersubunit interface [polypeptide binding]; other site
378806018271	active site
378806018272	catalytic residue [active]
378806018273	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
378806018274	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
378806018275	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
378806018276	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
378806018277	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
378806018278	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
378806018279	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
378806018280	TIGR02300 family protein; Region: FYDLN_acid
378806018281	Cna protein B-type domain; Region: Cna_B_2; pfam13715
378806018282	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
378806018283	Putative zinc ribbon domain; Region: DUF164; pfam02591
378806018284	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
378806018285	RNA/DNA hybrid binding site [nucleotide binding]; other site
378806018286	active site
378806018287	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
378806018288	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
378806018289	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
378806018290	GTP binding site [chemical binding]; other site
378806018291	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806018292	Zn binding site [ion binding]; other site
378806018293	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806018294	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
378806018295	active site
378806018296	catalytic site [active]
378806018297	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432
378806018298	ligand binding surface [chemical binding]; other site
378806018299	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806018300	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806018301	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
378806018302	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806018303	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
378806018304	NAD(P) binding site [chemical binding]; other site
378806018305	active site
378806018306	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
378806018307	active site 2 [active]
378806018308	active site 1 [active]
378806018309	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
378806018310	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
378806018311	Acyltransferase family; Region: Acyl_transf_3; pfam01757
378806018312	OpgC protein; Region: OpgC_C; pfam10129
378806018313	PEGA domain; Region: PEGA; pfam08308
378806018314	PEGA domain; Region: PEGA; pfam08308
378806018315	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
378806018316	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
378806018317	DXD motif; other site
378806018318	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
378806018319	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
378806018320	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806018321	PEGA domain; Region: PEGA; pfam08308
378806018322	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
378806018323	C-terminal peptidase (prc); Region: prc; TIGR00225
378806018324	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
378806018325	protein binding site [polypeptide binding]; other site
378806018326	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
378806018327	Catalytic dyad [active]
378806018328	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806018329	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806018330	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
378806018331	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
378806018332	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806018333	Walker A/P-loop; other site
378806018334	ATP binding site [chemical binding]; other site
378806018335	Q-loop/lid; other site
378806018336	ABC transporter signature motif; other site
378806018337	Walker B; other site
378806018338	D-loop; other site
378806018339	H-loop/switch region; other site
378806018340	photoactive yellow protein; Region: photo_yellow; TIGR02373
378806018341	Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520
378806018342	glutamate racemase; Provisional; Region: PRK00865
378806018343	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
378806018344	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
378806018345	TolR protein; Region: tolR; TIGR02801
378806018346	TolA protein; Region: tolA_full; TIGR02794
378806018347	TonB C terminal; Region: TonB_2; pfam13103
378806018348	TolB amino-terminal domain; Region: TolB_N; pfam04052
378806018349	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
378806018350	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806018351	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806018352	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806018353	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806018354	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806018355	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
378806018356	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806018357	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806018358	catalytic residue [active]
378806018359	exopolyphosphatase; Region: exo_poly_only; TIGR03706
378806018360	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
378806018361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806018362	D-galactonate transporter; Region: 2A0114; TIGR00893
378806018363	putative substrate translocation pore; other site
378806018364	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
378806018365	active site
378806018366	catalytic triad [active]
378806018367	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
378806018368	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
378806018369	Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [Inorganic ion transport and metabolism]; Region: NrfA; COG3303
378806018370	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806018371	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992
378806018372	putative acyl-acceptor binding pocket; other site
378806018373	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806018374	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
378806018375	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806018376	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806018377	Surface antigen; Region: Bac_surface_Ag; pfam01103
378806018378	Family of unknown function (DUF490); Region: DUF490; pfam04357
378806018379	Family of unknown function (DUF490); Region: DUF490; pfam04357
378806018380	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
378806018381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806018382	Walker A motif; other site
378806018383	ATP binding site [chemical binding]; other site
378806018384	Walker B motif; other site
378806018385	arginine finger; other site
378806018386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018387	binding surface
378806018388	TPR motif; other site
378806018389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018390	TPR motif; other site
378806018391	binding surface
378806018392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018393	binding surface
378806018394	TPR motif; other site
378806018395	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
378806018396	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
378806018397	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806018398	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
378806018399	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
378806018400	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
378806018401	carboxyltransferase (CT) interaction site; other site
378806018402	biotinylation site [posttranslational modification]; other site
378806018403	elongation factor P; Validated; Region: PRK00529
378806018404	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
378806018405	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
378806018406	RNA binding site [nucleotide binding]; other site
378806018407	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
378806018408	RNA binding site [nucleotide binding]; other site
378806018409	replicative DNA helicase; Validated; Region: PRK07773
378806018410	AMIN domain; Region: AMIN; pfam11741
378806018411	AMIN domain; Region: AMIN; pfam11741
378806018412	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
378806018413	Secretin and TonB N terminus short domain; Region: STN; pfam07660
378806018414	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
378806018415	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
378806018416	Pilus assembly protein, PilP; Region: PilP; pfam04351
378806018417	Pilus assembly protein, PilO; Region: PilO; pfam04350
378806018418	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
378806018419	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
378806018420	Competence protein A; Region: Competence_A; pfam11104
378806018421	Cell division protein FtsA; Region: FtsA; cl17206
378806018422	Cell division protein FtsA; Region: FtsA; pfam14450
378806018423	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806018424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806018425	active site
378806018426	phosphorylation site [posttranslational modification]
378806018427	intermolecular recognition site; other site
378806018428	dimerization interface [polypeptide binding]; other site
378806018429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806018430	Walker A motif; other site
378806018431	ATP binding site [chemical binding]; other site
378806018432	Walker B motif; other site
378806018433	arginine finger; other site
378806018434	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806018435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806018436	dimer interface [polypeptide binding]; other site
378806018437	phosphorylation site [posttranslational modification]
378806018438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806018439	ATP binding site [chemical binding]; other site
378806018440	Mg2+ binding site [ion binding]; other site
378806018441	G-X-G motif; other site
378806018442	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
378806018443	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
378806018444	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
378806018445	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
378806018446	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
378806018447	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
378806018448	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
378806018449	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
378806018450	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
378806018451	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
378806018452	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806018453	Walker A/P-loop; other site
378806018454	ATP binding site [chemical binding]; other site
378806018455	Q-loop/lid; other site
378806018456	ABC transporter signature motif; other site
378806018457	Walker B; other site
378806018458	D-loop; other site
378806018459	H-loop/switch region; other site
378806018460	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
378806018461	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806018462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806018463	active site
378806018464	phosphorylation site [posttranslational modification]
378806018465	intermolecular recognition site; other site
378806018466	dimerization interface [polypeptide binding]; other site
378806018467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806018468	Walker A motif; other site
378806018469	ATP binding site [chemical binding]; other site
378806018470	Walker B motif; other site
378806018471	arginine finger; other site
378806018472	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806018473	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806018474	PAS domain; Region: PAS; smart00091
378806018475	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806018476	phosphorylation site [posttranslational modification]
378806018477	dimer interface [polypeptide binding]; other site
378806018478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806018479	ATP binding site [chemical binding]; other site
378806018480	G-X-G motif; other site
378806018481	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
378806018482	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
378806018483	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
378806018484	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
378806018485	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806018486	Walker A motif; other site
378806018487	ATP binding site [chemical binding]; other site
378806018488	Walker B motif; other site
378806018489	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
378806018490	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806018491	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
378806018492	Walker A motif; other site
378806018493	ATP binding site [chemical binding]; other site
378806018494	Walker B motif; other site
378806018495	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
378806018496	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
378806018497	active site
378806018498	Riboflavin kinase; Region: Flavokinase; pfam01687
378806018499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806018500	S-adenosylmethionine binding site [chemical binding]; other site
378806018501	Response regulator receiver domain; Region: Response_reg; pfam00072
378806018502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806018503	active site
378806018504	phosphorylation site [posttranslational modification]
378806018505	intermolecular recognition site; other site
378806018506	dimerization interface [polypeptide binding]; other site
378806018507	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
378806018508	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806018509	metal binding site [ion binding]; metal-binding site
378806018510	active site
378806018511	I-site; other site
378806018512	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
378806018513	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
378806018514	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
378806018515	active site
378806018516	catalytic site [active]
378806018517	substrate binding site [chemical binding]; other site
378806018518	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
378806018519	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
378806018520	HEAT repeats; Region: HEAT_2; pfam13646
378806018521	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
378806018522	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
378806018523	motif 1; other site
378806018524	active site
378806018525	motif 2; other site
378806018526	motif 3; other site
378806018527	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
378806018528	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
378806018529	Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266
378806018530	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
378806018531	nucleotide binding site [chemical binding]; other site
378806018532	putative NEF/HSP70 interaction site [polypeptide binding]; other site
378806018533	SBD interface [polypeptide binding]; other site
378806018534	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
378806018535	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
378806018536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806018537	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
378806018538	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
378806018539	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
378806018540	putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900
378806018541	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
378806018542	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
378806018543	protein binding site [polypeptide binding]; other site
378806018544	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
378806018545	Catalytic dyad [active]
378806018546	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
378806018547	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
378806018548	active site
378806018549	catalytic site [active]
378806018550	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
378806018551	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
378806018552	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
378806018553	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
378806018554	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806018555	P-loop; other site
378806018556	Magnesium ion binding site [ion binding]; other site
378806018557	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806018558	Magnesium ion binding site [ion binding]; other site
378806018559	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
378806018560	DTAP/Switch II; other site
378806018561	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
378806018562	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
378806018563	P loop; other site
378806018564	Nucleotide binding site [chemical binding]; other site
378806018565	DTAP/Switch II; other site
378806018566	Switch I; other site
378806018567	TraB family; Region: TraB; cl12050
378806018568	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
378806018569	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018570	binding surface
378806018571	TPR motif; other site
378806018572	Peptidase family M48; Region: Peptidase_M48; cl12018
378806018573	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018574	TPR motif; other site
378806018575	binding surface
378806018576	TPR repeat; Region: TPR_11; pfam13414
378806018577	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
378806018578	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806018579	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806018580	structural tetrad; other site
378806018581	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
378806018582	PrkA AAA domain; Region: AAA_PrkA; smart00763
378806018583	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
378806018584	hypothetical protein; Provisional; Region: PRK05325
378806018585	SpoVR like protein; Region: SpoVR; pfam04293
378806018586	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
378806018587	putative peptidase; Provisional; Region: PRK11649
378806018588	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806018589	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
378806018590	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
378806018591	homodimer interface [polypeptide binding]; other site
378806018592	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
378806018593	active site pocket [active]
378806018594	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
378806018595	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
378806018596	active site
378806018597	Zn binding site [ion binding]; other site
378806018598	short chain dehydrogenase; Provisional; Region: PRK07576
378806018599	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
378806018600	NAD(P) binding site [chemical binding]; other site
378806018601	substrate binding site [chemical binding]; other site
378806018602	homotetramer interface [polypeptide binding]; other site
378806018603	active site
378806018604	homodimer interface [polypeptide binding]; other site
378806018605	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
378806018606	dimer interface [polypeptide binding]; other site
378806018607	substrate binding site [chemical binding]; other site
378806018608	Galactose oxidase, central domain; Region: Kelch_3; cl02701
378806018609	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
378806018610	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
378806018611	Cu(I) binding site [ion binding]; other site
378806018612	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
378806018613	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
378806018614	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
378806018615	active site
378806018616	PHP Thumb interface [polypeptide binding]; other site
378806018617	metal binding site [ion binding]; metal-binding site
378806018618	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
378806018619	generic binding surface II; other site
378806018620	generic binding surface I; other site
378806018621	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
378806018622	Sulfatase; Region: Sulfatase; cl17466
378806018623	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
378806018624	dimer interface [polypeptide binding]; other site
378806018625	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
378806018626	active site
378806018627	Zn binding site [ion binding]; other site
378806018628	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
378806018629	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
378806018630	[2Fe-2S] cluster binding site [ion binding]; other site
378806018631	iron-sulfur cluster [ion binding]; other site
378806018632	Cupin domain; Region: Cupin_2; pfam07883
378806018633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806018634	S-adenosylmethionine binding site [chemical binding]; other site
378806018635	Homeodomain-like domain; Region: HTH_23; pfam13384
378806018636	putative transposase OrfB; Reviewed; Region: PHA02517
378806018637	Homeodomain-like domain; Region: HTH_32; pfam13565
378806018638	Integrase core domain; Region: rve; pfam00665
378806018639	Integrase core domain; Region: rve_3; pfam13683
378806018640	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
378806018641	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
378806018642	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
378806018643	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
378806018644	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806018645	NAD(P) binding site [chemical binding]; other site
378806018646	active site
378806018647	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
378806018648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806018649	Coenzyme A binding pocket [chemical binding]; other site
378806018650	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
378806018651	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806018652	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806018653	Walker A motif; other site
378806018654	ATP binding site [chemical binding]; other site
378806018655	Walker B motif; other site
378806018656	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
378806018657	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
378806018658	Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983
378806018659	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
378806018660	hypothetical protein; Provisional; Region: PRK08204
378806018661	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806018662	active site
378806018663	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
378806018664	active site
378806018665	von Willebrand factor type A domain; Region: VWA_2; pfam13519
378806018666	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
378806018667	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
378806018668	Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248
378806018669	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
378806018670	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
378806018671	active site
378806018672	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
378806018673	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
378806018674	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806018675	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
378806018676	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
378806018677	DNA binding residues [nucleotide binding]
378806018678	helicase 45; Provisional; Region: PTZ00424
378806018679	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
378806018680	ATP binding site [chemical binding]; other site
378806018681	Mg++ binding site [ion binding]; other site
378806018682	motif III; other site
378806018683	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806018684	nucleotide binding region [chemical binding]; other site
378806018685	ATP-binding site [chemical binding]; other site
378806018686	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
378806018687	RNA binding site [nucleotide binding]; other site
378806018688	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
378806018689	glutamate dehydrogenase; Region: PLN02477
378806018690	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
378806018691	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
378806018692	NAD(P) binding site [chemical binding]; other site
378806018693	threonine dehydratase; Provisional; Region: PRK08198
378806018694	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
378806018695	tetramer interface [polypeptide binding]; other site
378806018696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806018697	catalytic residue [active]
378806018698	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
378806018699	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
378806018700	Uncharacterized conserved protein [Function unknown]; Region: COG2353
378806018701	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
378806018702	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
378806018703	putative active site [active]
378806018704	metal binding site [ion binding]; metal-binding site
378806018705	Activator of aromatic catabolism; Region: XylR_N; pfam06505
378806018706	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
378806018707	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806018708	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806018709	Walker A motif; other site
378806018710	ATP binding site [chemical binding]; other site
378806018711	Walker B motif; other site
378806018712	arginine finger; other site
378806018713	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806018714	Eukaryotic integral membrane protein (DUF1751); Region: DUF1751; pfam08551
378806018715	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
378806018716	putative acyltransferase; Provisional; Region: PRK05790
378806018717	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
378806018718	dimer interface [polypeptide binding]; other site
378806018719	active site
378806018720	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806018721	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806018722	active site
378806018723	ATP binding site [chemical binding]; other site
378806018724	substrate binding site [chemical binding]; other site
378806018725	activation loop (A-loop); other site
378806018726	AAA ATPase domain; Region: AAA_16; pfam13191
378806018727	Predicted ATPase [General function prediction only]; Region: COG3899
378806018728	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
378806018729	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
378806018730	active site
378806018731	substrate binding sites [chemical binding]; other site
378806018732	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806018733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806018734	active site
378806018735	phosphorylation site [posttranslational modification]
378806018736	intermolecular recognition site; other site
378806018737	dimerization interface [polypeptide binding]; other site
378806018738	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
378806018739	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
378806018740	Glutamate binding site [chemical binding]; other site
378806018741	NAD binding site [chemical binding]; other site
378806018742	catalytic residues [active]
378806018743	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
378806018744	active site
378806018745	catalytic residues [active]
378806018746	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
378806018747	TrkA-N domain; Region: TrkA_N; pfam02254
378806018748	TrkA-C domain; Region: TrkA_C; pfam02080
378806018749	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
378806018750	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
378806018751	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
378806018752	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806018753	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806018754	dimerization interface [polypeptide binding]; other site
378806018755	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806018756	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806018757	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806018758	dimer interface [polypeptide binding]; other site
378806018759	putative CheW interface [polypeptide binding]; other site
378806018760	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
378806018761	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
378806018762	active site
378806018763	Zn binding site [ion binding]; other site
378806018764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806018765	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806018766	active site
378806018767	phosphorylation site [posttranslational modification]
378806018768	intermolecular recognition site; other site
378806018769	dimerization interface [polypeptide binding]; other site
378806018770	GAF domain; Region: GAF; pfam01590
378806018771	GAF domain; Region: GAF_2; pfam13185
378806018772	GAF domain; Region: GAF; pfam01590
378806018773	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806018774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806018775	dimer interface [polypeptide binding]; other site
378806018776	phosphorylation site [posttranslational modification]
378806018777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806018778	ATP binding site [chemical binding]; other site
378806018779	Mg2+ binding site [ion binding]; other site
378806018780	G-X-G motif; other site
378806018781	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806018782	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806018783	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806018784	DNA-binding site [nucleotide binding]; DNA binding site
378806018785	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
378806018786	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806018787	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806018788	active site
378806018789	ATP binding site [chemical binding]; other site
378806018790	substrate binding site [chemical binding]; other site
378806018791	activation loop (A-loop); other site
378806018792	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
378806018793	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
378806018794	putative NAD(P) binding site [chemical binding]; other site
378806018795	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
378806018796	Transglycosylase; Region: Transgly; pfam00912
378806018797	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
378806018798	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
378806018799	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
378806018800	RNA binding surface [nucleotide binding]; other site
378806018801	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806018802	active site
378806018803	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
378806018804	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
378806018805	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
378806018806	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
378806018807	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
378806018808	EamA-like transporter family; Region: EamA; pfam00892
378806018809	EamA-like transporter family; Region: EamA; pfam00892
378806018810	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806018811	Coenzyme A binding pocket [chemical binding]; other site
378806018812	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806018813	Walker A/P-loop; other site
378806018814	ATP binding site [chemical binding]; other site
378806018815	Family description; Region: VCBS; pfam13517
378806018816	FG-GAP repeat; Region: FG-GAP; pfam01839
378806018817	Family description; Region: VCBS; pfam13517
378806018818	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
378806018819	Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695
378806018820	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
378806018821	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
378806018822	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
378806018823	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
378806018824	Ligand binding site [chemical binding]; other site
378806018825	Electron transfer flavoprotein domain; Region: ETF; pfam01012
378806018826	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806018827	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806018828	active site
378806018829	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
378806018830	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
378806018831	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
378806018832	active site
378806018833	intersubunit interactions; other site
378806018834	catalytic residue [active]
378806018835	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
378806018836	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
378806018837	putative active site [active]
378806018838	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
378806018839	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018840	binding surface
378806018841	TPR motif; other site
378806018842	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018843	binding surface
378806018844	TPR motif; other site
378806018845	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
378806018846	catalytic center binding site [active]
378806018847	ATP binding site [chemical binding]; other site
378806018848	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
378806018849	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
378806018850	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
378806018851	dihydrodipicolinate reductase; Provisional; Region: PRK00048
378806018852	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
378806018853	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
378806018854	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
378806018855	dihydrodipicolinate synthase; Region: dapA; TIGR00674
378806018856	dimer interface [polypeptide binding]; other site
378806018857	active site
378806018858	catalytic residue [active]
378806018859	diaminopimelate decarboxylase; Region: lysA; TIGR01048
378806018860	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
378806018861	active site
378806018862	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
378806018863	substrate binding site [chemical binding]; other site
378806018864	catalytic residues [active]
378806018865	dimer interface [polypeptide binding]; other site
378806018866	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
378806018867	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
378806018868	DNA binding site [nucleotide binding]
378806018869	catalytic residue [active]
378806018870	H2TH interface [polypeptide binding]; other site
378806018871	putative catalytic residues [active]
378806018872	turnover-facilitating residue; other site
378806018873	intercalation triad [nucleotide binding]; other site
378806018874	8OG recognition residue [nucleotide binding]; other site
378806018875	putative reading head residues; other site
378806018876	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
378806018877	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
378806018878	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
378806018879	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
378806018880	Peptidase family M48; Region: Peptidase_M48; pfam01435
378806018881	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
378806018882	epoxyqueuosine reductase; Region: TIGR00276
378806018883	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
378806018884	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
378806018885	thymidylate synthase; Reviewed; Region: thyA; PRK01827
378806018886	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
378806018887	dimerization interface [polypeptide binding]; other site
378806018888	active site
378806018889	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
378806018890	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
378806018891	folate binding site [chemical binding]; other site
378806018892	NADP+ binding site [chemical binding]; other site
378806018893	Cytochrome c; Region: Cytochrom_C; pfam00034
378806018894	Iron permease FTR1 family; Region: FTR1; cl00475
378806018895	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
378806018896	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
378806018897	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806018898	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
378806018899	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806018900	DNA binding residues [nucleotide binding]
378806018901	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
378806018902	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806018903	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
378806018904	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806018905	Zn2+ binding site [ion binding]; other site
378806018906	Mg2+ binding site [ion binding]; other site
378806018907	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806018908	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806018909	Coenzyme A binding pocket [chemical binding]; other site
378806018910	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
378806018911	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
378806018912	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806018913	putative catalytic site [active]
378806018914	putative metal binding site [ion binding]; other site
378806018915	putative phosphate binding site [ion binding]; other site
378806018916	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
378806018917	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806018918	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
378806018919	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806018920	Histidine kinase; Region: HisKA_3; pfam07730
378806018921	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
378806018922	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806018923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806018924	active site
378806018925	phosphorylation site [posttranslational modification]
378806018926	intermolecular recognition site; other site
378806018927	dimerization interface [polypeptide binding]; other site
378806018928	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806018929	DNA binding residues [nucleotide binding]
378806018930	dimerization interface [polypeptide binding]; other site
378806018931	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806018932	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806018933	DNA-binding site [nucleotide binding]; DNA binding site
378806018934	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
378806018935	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
378806018936	active site
378806018937	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
378806018938	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
378806018939	homodimer interface [polypeptide binding]; other site
378806018940	substrate-cofactor binding pocket; other site
378806018941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806018942	catalytic residue [active]
378806018943	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806018944	dimer interface [polypeptide binding]; other site
378806018945	phosphorylation site [posttranslational modification]
378806018946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806018947	ATP binding site [chemical binding]; other site
378806018948	G-X-G motif; other site
378806018949	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806018950	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806018951	active site
378806018952	ATP binding site [chemical binding]; other site
378806018953	substrate binding site [chemical binding]; other site
378806018954	activation loop (A-loop); other site
378806018955	PEGA domain; Region: PEGA; pfam08308
378806018956	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806018957	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806018958	phosphopeptide binding site; other site
378806018959	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806018960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806018961	Walker A motif; other site
378806018962	ATP binding site [chemical binding]; other site
378806018963	Walker B motif; other site
378806018964	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806018965	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806018966	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
378806018967	Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243
378806018968	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
378806018969	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
378806018970	active site
378806018971	nucleophile elbow; other site
378806018972	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
378806018973	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
378806018974	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
378806018975	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
378806018976	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806018977	TPR repeat; Region: TPR_11; pfam13414
378806018978	TPR motif; other site
378806018979	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
378806018980	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806018981	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806018982	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
378806018983	FeS/SAM binding site; other site
378806018984	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
378806018985	Radical SAM superfamily; Region: Radical_SAM; pfam04055
378806018986	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806018987	FeS/SAM binding site; other site
378806018988	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806018989	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
378806018990	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; pfam02709
378806018991	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
378806018992	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
378806018993	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806018994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806018995	dimer interface [polypeptide binding]; other site
378806018996	phosphorylation site [posttranslational modification]
378806018997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806018998	ATP binding site [chemical binding]; other site
378806018999	Mg2+ binding site [ion binding]; other site
378806019000	G-X-G motif; other site
378806019001	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
378806019002	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
378806019003	Ligand binding site; other site
378806019004	Putative Catalytic site; other site
378806019005	DXD motif; other site
378806019006	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
378806019007	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
378806019008	catalytic residues [active]
378806019009	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
378806019010	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
378806019011	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
378806019012	Trehalase; Region: Trehalase; cl17346
378806019013	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806019014	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
378806019015	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
378806019016	Ca binding site [ion binding]; other site
378806019017	DNA helicase, putative; Region: TIGR00376
378806019018	Part of AAA domain; Region: AAA_19; pfam13245
378806019019	AAA domain; Region: AAA_12; pfam13087
378806019020	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
378806019021	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
378806019022	catalytic loop [active]
378806019023	iron binding site [ion binding]; other site
378806019024	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
378806019025	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
378806019026	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
378806019027	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
378806019028	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
378806019029	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806019030	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806019031	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806019032	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806019033	active site
378806019034	ATP binding site [chemical binding]; other site
378806019035	substrate binding site [chemical binding]; other site
378806019036	activation loop (A-loop); other site
378806019037	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
378806019038	tellurite resistance protein terB; Region: terB; cd07176
378806019039	putative metal binding site [ion binding]; other site
378806019040	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
378806019041	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
378806019042	Ligand Binding Site [chemical binding]; other site
378806019043	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
378806019044	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
378806019045	catalytic site [active]
378806019046	putative active site [active]
378806019047	putative substrate binding site [chemical binding]; other site
378806019048	HRDC domain; Region: HRDC; pfam00570
378806019049	HRDC domain; Region: HRDC; pfam00570
378806019050	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
378806019051	dimerization interface [polypeptide binding]; other site
378806019052	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
378806019053	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
378806019054	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
378806019055	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
378806019056	active site
378806019057	Zn binding site [ion binding]; other site
378806019058	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
378806019059	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
378806019060	G1 box; other site
378806019061	putative GEF interaction site [polypeptide binding]; other site
378806019062	GTP/Mg2+ binding site [chemical binding]; other site
378806019063	Switch I region; other site
378806019064	G2 box; other site
378806019065	G3 box; other site
378806019066	Switch II region; other site
378806019067	G4 box; other site
378806019068	G5 box; other site
378806019069	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
378806019070	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
378806019071	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
378806019072	PGAP1-like protein; Region: PGAP1; pfam07819
378806019073	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
378806019074	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
378806019075	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
378806019076	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
378806019077	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
378806019078	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806019079	Walker A/P-loop; other site
378806019080	ATP binding site [chemical binding]; other site
378806019081	Q-loop/lid; other site
378806019082	ABC transporter signature motif; other site
378806019083	Walker B; other site
378806019084	D-loop; other site
378806019085	H-loop/switch region; other site
378806019086	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806019087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806019088	S-adenosylmethionine binding site [chemical binding]; other site
378806019089	Uncharacterized conserved protein [Function unknown]; Region: COG4278
378806019090	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806019091	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806019092	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806019093	binding surface
378806019094	TPR motif; other site
378806019095	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806019096	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806019097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806019098	binding surface
378806019099	TPR motif; other site
378806019100	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806019101	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806019102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806019103	TPR motif; other site
378806019104	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806019105	binding surface
378806019106	CHAT domain; Region: CHAT; pfam12770
378806019107	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806019108	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806019109	active site
378806019110	catalytic tetrad [active]
378806019111	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806019112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806019113	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
378806019114	putative effector binding pocket; other site
378806019115	putative dimerization interface [polypeptide binding]; other site
378806019116	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806019117	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806019118	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806019119	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
378806019120	protein-splicing catalytic site; other site
378806019121	thioester formation/cholesterol transfer; other site
378806019122	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
378806019123	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
378806019124	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
378806019125	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
378806019126	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
378806019127	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
378806019128	active site
378806019129	dimer interface [polypeptide binding]; other site
378806019130	motif 1; other site
378806019131	motif 2; other site
378806019132	motif 3; other site
378806019133	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
378806019134	anticodon binding site; other site
378806019135	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349
378806019136	active site
378806019137	DEAD-like helicases superfamily; Region: DEXDc; smart00487
378806019138	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806019139	ATP binding site [chemical binding]; other site
378806019140	putative Mg++ binding site [ion binding]; other site
378806019141	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
378806019142	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806019143	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
378806019144	Response regulator receiver domain; Region: Response_reg; pfam00072
378806019145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019146	active site
378806019147	phosphorylation site [posttranslational modification]
378806019148	intermolecular recognition site; other site
378806019149	dimerization interface [polypeptide binding]; other site
378806019150	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
378806019151	HSP70 interaction site [polypeptide binding]; other site
378806019152	PilZ domain; Region: PilZ; cl01260
378806019153	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806019154	putative active site [active]
378806019155	heme pocket [chemical binding]; other site
378806019156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806019157	dimer interface [polypeptide binding]; other site
378806019158	phosphorylation site [posttranslational modification]
378806019159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019160	ATP binding site [chemical binding]; other site
378806019161	Mg2+ binding site [ion binding]; other site
378806019162	G-X-G motif; other site
378806019163	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
378806019164	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806019165	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
378806019166	FAD binding pocket [chemical binding]; other site
378806019167	FAD binding motif [chemical binding]; other site
378806019168	phosphate binding motif [ion binding]; other site
378806019169	beta-alpha-beta structure motif; other site
378806019170	NAD(p) ribose binding residues [chemical binding]; other site
378806019171	NAD binding pocket [chemical binding]; other site
378806019172	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
378806019173	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
378806019174	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
378806019175	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
378806019176	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
378806019177	Protein of unknown function, DUF482; Region: DUF482; pfam04339
378806019178	Uncharacterized conserved protein [Function unknown]; Region: COG2127
378806019179	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
378806019180	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806019181	Walker A motif; other site
378806019182	ATP binding site [chemical binding]; other site
378806019183	Walker B motif; other site
378806019184	arginine finger; other site
378806019185	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806019186	Walker A motif; other site
378806019187	ATP binding site [chemical binding]; other site
378806019188	Walker B motif; other site
378806019189	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
378806019190	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
378806019191	Citrate synthase; Region: Citrate_synt; pfam00285
378806019192	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
378806019193	dimer interface [polypeptide binding]; other site
378806019194	active site
378806019195	oxalacetate/citrate binding site [chemical binding]; other site
378806019196	citrylCoA binding site [chemical binding]; other site
378806019197	coenzyme A binding site [chemical binding]; other site
378806019198	catalytic triad [active]
378806019199	Cupin domain; Region: Cupin_2; cl17218
378806019200	GTPase RsgA; Reviewed; Region: PRK01889
378806019201	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
378806019202	RNA binding site [nucleotide binding]; other site
378806019203	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
378806019204	GTPase/Zn-binding domain interface [polypeptide binding]; other site
378806019205	GTP/Mg2+ binding site [chemical binding]; other site
378806019206	G4 box; other site
378806019207	G5 box; other site
378806019208	G1 box; other site
378806019209	Switch I region; other site
378806019210	G2 box; other site
378806019211	G3 box; other site
378806019212	Switch II region; other site
378806019213	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806019214	dimerization interface [polypeptide binding]; other site
378806019215	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806019216	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806019217	dimer interface [polypeptide binding]; other site
378806019218	putative CheW interface [polypeptide binding]; other site
378806019219	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
378806019220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019221	active site
378806019222	phosphorylation site [posttranslational modification]
378806019223	intermolecular recognition site; other site
378806019224	dimerization interface [polypeptide binding]; other site
378806019225	CheB methylesterase; Region: CheB_methylest; pfam01339
378806019226	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
378806019227	putative binding surface; other site
378806019228	active site
378806019229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019230	ATP binding site [chemical binding]; other site
378806019231	Mg2+ binding site [ion binding]; other site
378806019232	G-X-G motif; other site
378806019233	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
378806019234	Response regulator receiver domain; Region: Response_reg; pfam00072
378806019235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019236	active site
378806019237	phosphorylation site [posttranslational modification]
378806019238	intermolecular recognition site; other site
378806019239	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
378806019240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806019241	S-adenosylmethionine binding site [chemical binding]; other site
378806019242	Response regulator receiver domain; Region: Response_reg; pfam00072
378806019243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019244	active site
378806019245	phosphorylation site [posttranslational modification]
378806019246	intermolecular recognition site; other site
378806019247	dimerization interface [polypeptide binding]; other site
378806019248	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
378806019249	Response regulator receiver domain; Region: Response_reg; pfam00072
378806019250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019251	active site
378806019252	phosphorylation site [posttranslational modification]
378806019253	intermolecular recognition site; other site
378806019254	dimerization interface [polypeptide binding]; other site
378806019255	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
378806019256	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
378806019257	NAD binding site [chemical binding]; other site
378806019258	homotetramer interface [polypeptide binding]; other site
378806019259	homodimer interface [polypeptide binding]; other site
378806019260	substrate binding site [chemical binding]; other site
378806019261	active site
378806019262	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
378806019263	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
378806019264	TPP-binding site [chemical binding]; other site
378806019265	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
378806019266	dimer interface [polypeptide binding]; other site
378806019267	PYR/PP interface [polypeptide binding]; other site
378806019268	TPP binding site [chemical binding]; other site
378806019269	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
378806019270	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
378806019271	E3 interaction surface; other site
378806019272	lipoyl attachment site [posttranslational modification]; other site
378806019273	e3 binding domain; Region: E3_binding; pfam02817
378806019274	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
378806019275	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
378806019276	DNA-binding site [nucleotide binding]; DNA binding site
378806019277	RNA-binding motif; other site
378806019278	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
378806019279	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806019280	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806019281	UPF0489 domain; Region: UPF0489; pfam12640
378806019282	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806019283	active site
378806019284	ATP binding site [chemical binding]; other site
378806019285	substrate binding site [chemical binding]; other site
378806019286	activation loop (A-loop); other site
378806019287	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806019288	Transposase; Region: HTH_Tnp_1; cl17663
378806019289	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806019290	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806019291	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806019292	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806019293	active site
378806019294	catalytic tetrad [active]
378806019295	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
378806019296	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806019297	putative DNA binding site [nucleotide binding]; other site
378806019298	putative Zn2+ binding site [ion binding]; other site
378806019299	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
378806019300	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806019301	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806019302	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
378806019303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806019304	putative substrate translocation pore; other site
378806019305	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806019306	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806019307	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806019308	Predicted chitinase [General function prediction only]; Region: COG3179
378806019309	catalytic residue [active]
378806019310	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
378806019311	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
378806019312	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
378806019313	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
378806019314	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
378806019315	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
378806019316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806019317	NAD(P) binding site [chemical binding]; other site
378806019318	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
378806019319	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806019320	active site
378806019321	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
378806019322	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
378806019323	Kelch domain; Region: Kelch; smart00612
378806019324	Surface antigen; Region: Bac_surface_Ag; pfam01103
378806019325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019326	active site
378806019327	phosphorylation site [posttranslational modification]
378806019328	intermolecular recognition site; other site
378806019329	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
378806019330	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
378806019331	cobalamin binding residues [chemical binding]; other site
378806019332	putative BtuC binding residues; other site
378806019333	dimer interface [polypeptide binding]; other site
378806019334	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806019335	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806019336	active site
378806019337	ATP binding site [chemical binding]; other site
378806019338	substrate binding site [chemical binding]; other site
378806019339	activation loop (A-loop); other site
378806019340	TPR repeat; Region: TPR_11; pfam13414
378806019341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806019342	binding surface
378806019343	TPR motif; other site
378806019344	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
378806019345	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
378806019346	N-terminal plug; other site
378806019347	ligand-binding site [chemical binding]; other site
378806019348	Response regulator receiver domain; Region: Response_reg; pfam00072
378806019349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019350	active site
378806019351	phosphorylation site [posttranslational modification]
378806019352	intermolecular recognition site; other site
378806019353	dimerization interface [polypeptide binding]; other site
378806019354	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
378806019355	Transglycosylase; Region: Transgly; pfam00912
378806019356	Pirin-related protein [General function prediction only]; Region: COG1741
378806019357	Pirin; Region: Pirin; pfam02678
378806019358	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
378806019359	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806019360	Protein kinase domain; Region: Pkinase; pfam00069
378806019361	active site
378806019362	ATP binding site [chemical binding]; other site
378806019363	substrate binding site [chemical binding]; other site
378806019364	activation loop (A-loop); other site
378806019365	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
378806019366	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806019367	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806019368	dimerization interface [polypeptide binding]; other site
378806019369	putative DNA binding site [nucleotide binding]; other site
378806019370	putative Zn2+ binding site [ion binding]; other site
378806019371	Predicted membrane protein [Function unknown]; Region: COG2259
378806019372	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806019373	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806019374	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806019375	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
378806019376	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
378806019377	Beta/Gamma crystallin; Region: Crystall; cl02528
378806019378	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
378806019379	TMAO/DMSO reductase; Reviewed; Region: PRK05363
378806019380	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
378806019381	Moco binding site; other site
378806019382	metal coordination site [ion binding]; other site
378806019383	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
378806019384	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806019385	putative di-iron ligands [ion binding]; other site
378806019386	Nudix hydrolase homolog; Region: PLN02791
378806019387	heat shock protein 90; Provisional; Region: PRK05218
378806019388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019389	ATP binding site [chemical binding]; other site
378806019390	Mg2+ binding site [ion binding]; other site
378806019391	G-X-G motif; other site
378806019392	CAAX protease self-immunity; Region: Abi; cl00558
378806019393	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
378806019394	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
378806019395	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
378806019396	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
378806019397	active site
378806019398	ribulose/triose binding site [chemical binding]; other site
378806019399	phosphate binding site [ion binding]; other site
378806019400	substrate (anthranilate) binding pocket [chemical binding]; other site
378806019401	product (indole) binding pocket [chemical binding]; other site
378806019402	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
378806019403	active site
378806019404	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
378806019405	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
378806019406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806019407	catalytic residue [active]
378806019408	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
378806019409	substrate binding site [chemical binding]; other site
378806019410	active site
378806019411	catalytic residues [active]
378806019412	heterodimer interface [polypeptide binding]; other site
378806019413	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
378806019414	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
378806019415	glutamine binding [chemical binding]; other site
378806019416	catalytic triad [active]
378806019417	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
378806019418	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
378806019419	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
378806019420	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
378806019421	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806019422	ATP-dependent DNA ligase; Validated; Region: PRK09247
378806019423	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
378806019424	active site
378806019425	DNA binding site [nucleotide binding]
378806019426	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
378806019427	DNA binding site [nucleotide binding]
378806019428	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
378806019429	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806019430	ATP binding site [chemical binding]; other site
378806019431	putative Mg++ binding site [ion binding]; other site
378806019432	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806019433	nucleotide binding region [chemical binding]; other site
378806019434	ATP-binding site [chemical binding]; other site
378806019435	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
378806019436	DEAD/H associated; Region: DEAD_assoc; pfam08494
378806019437	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
378806019438	putative active site [active]
378806019439	putative metal binding site [ion binding]; other site
378806019440	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
378806019441	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
378806019442	active site
378806019443	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
378806019444	heme-binding residues [chemical binding]; other site
378806019445	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
378806019446	molybdopterin cofactor binding site; other site
378806019447	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
378806019448	4Fe-4S binding domain; Region: Fer4; cl02805
378806019449	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
378806019450	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
378806019451	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
378806019452	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
378806019453	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
378806019454	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
378806019455	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
378806019456	Cu(I) binding site [ion binding]; other site
378806019457	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
378806019458	Cytochrome c; Region: Cytochrom_C; pfam00034
378806019459	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
378806019460	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
378806019461	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
378806019462	Subunit I/III interface [polypeptide binding]; other site
378806019463	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
378806019464	Protein of unknown function, DUF481; Region: DUF481; pfam04338
378806019465	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
378806019466	Flagellin N-methylase; Region: FliB; pfam03692
378806019467	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
378806019468	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806019469	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806019470	DNA binding residues [nucleotide binding]
378806019471	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
378806019472	RmuC family; Region: RmuC; pfam02646
378806019473	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
378806019474	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806019475	ATP binding site [chemical binding]; other site
378806019476	putative Mg++ binding site [ion binding]; other site
378806019477	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806019478	nucleotide binding region [chemical binding]; other site
378806019479	ATP-binding site [chemical binding]; other site
378806019480	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
378806019481	Protein of unknown function (DUF790); Region: DUF790; pfam05626
378806019482	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806019483	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806019484	sequence-specific DNA binding site [nucleotide binding]; other site
378806019485	salt bridge; other site
378806019486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019487	active site
378806019488	phosphorylation site [posttranslational modification]
378806019489	intermolecular recognition site; other site
378806019490	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
378806019491	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
378806019492	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
378806019493	PYR/PP interface [polypeptide binding]; other site
378806019494	dimer interface [polypeptide binding]; other site
378806019495	TPP binding site [chemical binding]; other site
378806019496	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
378806019497	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
378806019498	TPP-binding site [chemical binding]; other site
378806019499	dimer interface [polypeptide binding]; other site
378806019500	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
378806019501	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
378806019502	putative valine binding site [chemical binding]; other site
378806019503	dimer interface [polypeptide binding]; other site
378806019504	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
378806019505	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
378806019506	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
378806019507	homodimer interface [polypeptide binding]; other site
378806019508	substrate-cofactor binding pocket; other site
378806019509	catalytic residue [active]
378806019510	ketol-acid reductoisomerase; Provisional; Region: PRK05479
378806019511	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
378806019512	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
378806019513	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
378806019514	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
378806019515	C-terminal domain interface [polypeptide binding]; other site
378806019516	GSH binding site (G-site) [chemical binding]; other site
378806019517	dimer interface [polypeptide binding]; other site
378806019518	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
378806019519	N-terminal domain interface [polypeptide binding]; other site
378806019520	dimer interface [polypeptide binding]; other site
378806019521	substrate binding pocket (H-site) [chemical binding]; other site
378806019522	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
378806019523	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806019524	Walker A motif; other site
378806019525	ATP binding site [chemical binding]; other site
378806019526	Walker B motif; other site
378806019527	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
378806019528	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
378806019529	active site
378806019530	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
378806019531	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
378806019532	catalytic site [active]
378806019533	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019534	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806019535	ATP binding site [chemical binding]; other site
378806019536	G-X-G motif; other site
378806019537	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806019538	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
378806019539	active site
378806019540	ATP binding site [chemical binding]; other site
378806019541	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
378806019542	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806019543	bile acid transporter; Region: bass; TIGR00841
378806019544	Sodium Bile acid symporter family; Region: SBF; cl17470
378806019545	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
378806019546	putative active site [active]
378806019547	putative metal binding site [ion binding]; other site
378806019548	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
378806019549	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
378806019550	heterodimer interface [polypeptide binding]; other site
378806019551	substrate interaction site [chemical binding]; other site
378806019552	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
378806019553	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
378806019554	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
378806019555	active site
378806019556	substrate binding site [chemical binding]; other site
378806019557	coenzyme B12 binding site [chemical binding]; other site
378806019558	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
378806019559	B12 binding site [chemical binding]; other site
378806019560	cobalt ligand [ion binding]; other site
378806019561	membrane ATPase/protein kinase; Provisional; Region: PRK09435
378806019562	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
378806019563	Walker A; other site
378806019564	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
378806019565	B12 binding site [chemical binding]; other site
378806019566	cobalt ligand [ion binding]; other site
378806019567	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
378806019568	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
378806019569	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
378806019570	N-formylglutamate amidohydrolase; Region: FGase; cl01522
378806019571	Isochorismatase family; Region: Isochorismatase; pfam00857
378806019572	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
378806019573	catalytic triad [active]
378806019574	conserved cis-peptide bond; other site
378806019575	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
378806019576	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
378806019577	Protein kinase domain; Region: Pkinase; pfam00069
378806019578	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806019579	active site
378806019580	ATP binding site [chemical binding]; other site
378806019581	substrate binding site [chemical binding]; other site
378806019582	activation loop (A-loop); other site
378806019583	Methyltransferase domain; Region: Methyltransf_31; pfam13847
378806019584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806019585	S-adenosylmethionine binding site [chemical binding]; other site
378806019586	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806019587	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
378806019588	active site
378806019589	metal binding site [ion binding]; metal-binding site
378806019590	MarR family; Region: MarR_2; pfam12802
378806019591	Transcriptional regulators [Transcription]; Region: MarR; COG1846
378806019592	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806019593	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806019594	active site
378806019595	ATP binding site [chemical binding]; other site
378806019596	substrate binding site [chemical binding]; other site
378806019597	activation loop (A-loop); other site
378806019598	Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791
378806019599	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
378806019600	active site
378806019601	zinc binding site [ion binding]; other site
378806019602	RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001
378806019603	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806019604	DNA binding residues [nucleotide binding]
378806019605	Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219
378806019606	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806019607	active site
378806019608	ATP binding site [chemical binding]; other site
378806019609	substrate binding site [chemical binding]; other site
378806019610	activation loop (A-loop); other site
378806019611	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806019612	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806019613	HEAT repeats; Region: HEAT_2; pfam13646
378806019614	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
378806019615	DNA binding site [nucleotide binding]
378806019616	active site
378806019617	Int/Topo IB signature motif; other site
378806019618	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
378806019619	helix-hairpin-helix signature motif; other site
378806019620	active site
378806019621	Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603
378806019622	Ligand Binding Site [chemical binding]; other site
378806019623	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
378806019624	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
378806019625	ATP binding site [chemical binding]; other site
378806019626	substrate binding site [chemical binding]; other site
378806019627	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
378806019628	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
378806019629	Putative addiction module component; Region: Unstab_antitox; cl09921
378806019630	Response regulator receiver domain; Region: Response_reg; pfam00072
378806019631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019632	active site
378806019633	phosphorylation site [posttranslational modification]
378806019634	intermolecular recognition site; other site
378806019635	dimerization interface [polypeptide binding]; other site
378806019636	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
378806019637	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
378806019638	substrate binding site [chemical binding]; other site
378806019639	hexamer interface [polypeptide binding]; other site
378806019640	metal binding site [ion binding]; metal-binding site
378806019641	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806019642	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806019643	Zn2+ binding site [ion binding]; other site
378806019644	Mg2+ binding site [ion binding]; other site
378806019645	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806019646	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
378806019647	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
378806019648	domain interfaces; other site
378806019649	active site
378806019650	Flagellin N-methylase; Region: FliB; cl00497
378806019651	Domain of unknown function (DUF814); Region: DUF814; pfam05670
378806019652	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
378806019653	beta-galactosidase; Region: BGL; TIGR03356
378806019654	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
378806019655	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
378806019656	FMN binding site [chemical binding]; other site
378806019657	active site
378806019658	catalytic residues [active]
378806019659	substrate binding site [chemical binding]; other site
378806019660	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
378806019661	active site
378806019662	Peptidase family M50; Region: Peptidase_M50; pfam02163
378806019663	putative substrate binding region [chemical binding]; other site
378806019664	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
378806019665	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806019666	Di-iron ligands [ion binding]; other site
378806019667	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806019668	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806019669	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
378806019670	DNA binding residues [nucleotide binding]
378806019671	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
378806019672	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
378806019673	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
378806019674	Outer membrane efflux protein; Region: OEP; pfam02321
378806019675	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
378806019676	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
378806019677	metal-binding site [ion binding]
378806019678	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
378806019679	Soluble P-type ATPase [General function prediction only]; Region: COG4087
378806019680	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
378806019681	Pirin; Region: Pirin; pfam02678
378806019682	Pirin-related protein [General function prediction only]; Region: COG1741
378806019683	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
378806019684	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824
378806019685	putative hydrophobic ligand binding site [chemical binding]; other site
378806019686	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
378806019687	putative hydrophobic ligand binding site [chemical binding]; other site
378806019688	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806019689	Cytochrome P450; Region: p450; cl12078
378806019690	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
378806019691	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
378806019692	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
378806019693	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
378806019694	catalytic triad [active]
378806019695	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806019696	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
378806019697	active site
378806019698	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806019699	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806019700	active site
378806019701	ATP binding site [chemical binding]; other site
378806019702	substrate binding site [chemical binding]; other site
378806019703	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806019704	substrate binding site [chemical binding]; other site
378806019705	activation loop (A-loop); other site
378806019706	activation loop (A-loop); other site
378806019707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806019708	TPR motif; other site
378806019709	binding surface
378806019710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
378806019711	TPR motif; other site
378806019712	binding surface
378806019713	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806019714	binding surface
378806019715	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
378806019716	GAF domain; Region: GAF_2; pfam13185
378806019717	GAF domain; Region: GAF_3; pfam13492
378806019718	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806019719	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
378806019720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019721	ATP binding site [chemical binding]; other site
378806019722	Mg2+ binding site [ion binding]; other site
378806019723	G-X-G motif; other site
378806019724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
378806019725	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
378806019726	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806019727	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806019728	DNA-binding site [nucleotide binding]; DNA binding site
378806019729	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
378806019730	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
378806019731	active site
378806019732	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806019733	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806019734	active site
378806019735	ATP binding site [chemical binding]; other site
378806019736	substrate binding site [chemical binding]; other site
378806019737	activation loop (A-loop); other site
378806019738	HAMP domain; Region: HAMP; pfam00672
378806019739	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806019740	cyclase homology domain; Region: CHD; cd07302
378806019741	nucleotidyl binding site; other site
378806019742	metal binding site [ion binding]; metal-binding site
378806019743	dimer interface [polypeptide binding]; other site
378806019744	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
378806019745	Protein of unknown function (DUF328); Region: DUF328; cl01143
378806019746	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
378806019747	DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172
378806019748	DGQHR domain; Region: DGQHR; TIGR03187
378806019749	Putative cyclase; Region: Cyclase; pfam04199
378806019750	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
378806019751	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806019752	Coenzyme A binding pocket [chemical binding]; other site
378806019753	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain; Region: NMT_C; pfam02799
378806019754	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806019755	S-adenosylmethionine binding site [chemical binding]; other site
378806019756	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
378806019757	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
378806019758	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
378806019759	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806019760	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806019761	active site
378806019762	ATP binding site [chemical binding]; other site
378806019763	substrate binding site [chemical binding]; other site
378806019764	activation loop (A-loop); other site
378806019765	short chain dehydrogenase; Provisional; Region: PRK06179
378806019766	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
378806019767	NADP binding site [chemical binding]; other site
378806019768	active site
378806019769	steroid binding site; other site
378806019770	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
378806019771	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
378806019772	active site
378806019773	putative substrate binding pocket [chemical binding]; other site
378806019774	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806019775	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
378806019776	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806019777	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
378806019778	C-terminal domain interface [polypeptide binding]; other site
378806019779	GSH binding site (G-site) [chemical binding]; other site
378806019780	dimer interface [polypeptide binding]; other site
378806019781	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
378806019782	N-terminal domain interface [polypeptide binding]; other site
378806019783	dimer interface [polypeptide binding]; other site
378806019784	substrate binding pocket (H-site) [chemical binding]; other site
378806019785	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806019786	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806019787	active site
378806019788	ATP binding site [chemical binding]; other site
378806019789	substrate binding site [chemical binding]; other site
378806019790	activation loop (A-loop); other site
378806019791	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806019792	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
378806019793	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
378806019794	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
378806019795	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
378806019796	putative domain interface [polypeptide binding]; other site
378806019797	putative active site [active]
378806019798	catalytic site [active]
378806019799	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
378806019800	putative domain interface [polypeptide binding]; other site
378806019801	putative active site [active]
378806019802	catalytic site [active]
378806019803	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
378806019804	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
378806019805	nucleotide binding site [chemical binding]; other site
378806019806	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
378806019807	Zn2+ binding site [ion binding]; other site
378806019808	Mg2+ binding site [ion binding]; other site
378806019809	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
378806019810	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
378806019811	NAD binding site [chemical binding]; other site
378806019812	catalytic Zn binding site [ion binding]; other site
378806019813	structural Zn binding site [ion binding]; other site
378806019814	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
378806019815	ATP adenylyltransferase; Region: ATP_transf; pfam09830
378806019816	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
378806019817	Protein of unknown function (DUF1444); Region: DUF1444; cl02011
378806019818	PAS domain; Region: PAS_9; pfam13426
378806019819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806019820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019821	ATP binding site [chemical binding]; other site
378806019822	G-X-G motif; other site
378806019823	Response regulator receiver domain; Region: Response_reg; pfam00072
378806019824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019825	active site
378806019826	phosphorylation site [posttranslational modification]
378806019827	intermolecular recognition site; other site
378806019828	dimerization interface [polypeptide binding]; other site
378806019829	Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028
378806019830	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
378806019831	tartrate dehydrogenase; Region: TTC; TIGR02089
378806019832	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
378806019833	catalytic residues [active]
378806019834	dimer interface [polypeptide binding]; other site
378806019835	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
378806019836	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806019837	catalytic residues [active]
378806019838	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
378806019839	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
378806019840	catalytic triad [active]
378806019841	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806019842	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806019843	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
378806019844	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806019845	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
378806019846	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
378806019847	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806019848	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806019849	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806019850	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806019851	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
378806019852	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806019853	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
378806019854	Transaldolase; Region: Transaldolase; pfam00923
378806019855	catalytic residue [active]
378806019856	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
378806019857	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
378806019858	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
378806019859	PYR/PP interface [polypeptide binding]; other site
378806019860	dimer interface [polypeptide binding]; other site
378806019861	TPP binding site [chemical binding]; other site
378806019862	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
378806019863	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
378806019864	TPP-binding site [chemical binding]; other site
378806019865	KduI/IolB family; Region: KduI; pfam04962
378806019866	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
378806019867	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
378806019868	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
378806019869	Thioredoxin; Region: Thioredoxin_4; cl17273
378806019870	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
378806019871	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
378806019872	Thioredoxin; Region: Thioredoxin_4; cl17273
378806019873	Thioredoxin; Region: Thioredoxin_4; pfam13462
378806019874	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
378806019875	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
378806019876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806019877	S-adenosylmethionine binding site [chemical binding]; other site
378806019878	enoyl-CoA hydratase; Provisional; Region: PRK06142
378806019879	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
378806019880	substrate binding site [chemical binding]; other site
378806019881	oxyanion hole (OAH) forming residues; other site
378806019882	trimer interface [polypeptide binding]; other site
378806019883	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
378806019884	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
378806019885	acyl-activating enzyme (AAE) consensus motif; other site
378806019886	active site
378806019887	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806019888	Condensation domain; Region: Condensation; pfam00668
378806019889	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
378806019890	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
378806019891	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
378806019892	acyl-activating enzyme (AAE) consensus motif; other site
378806019893	AMP binding site [chemical binding]; other site
378806019894	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806019895	Condensation domain; Region: Condensation; pfam00668
378806019896	Nonribosomal peptide synthase; Region: NRPS; pfam08415
378806019897	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
378806019898	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
378806019899	acyl-activating enzyme (AAE) consensus motif; other site
378806019900	AMP binding site [chemical binding]; other site
378806019901	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
378806019902	Condensation domain; Region: Condensation; pfam00668
378806019903	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
378806019904	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806019905	S-adenosylmethionine binding site [chemical binding]; other site
378806019906	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806019907	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806019908	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806019909	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
378806019910	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
378806019911	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806019912	motif II; other site
378806019913	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
378806019914	short chain dehydrogenase; Provisional; Region: PRK07454
378806019915	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
378806019916	NADP binding site [chemical binding]; other site
378806019917	substrate binding site [chemical binding]; other site
378806019918	active site
378806019919	GAF domain; Region: GAF_3; pfam13492
378806019920	GAF domain; Region: GAF_2; pfam13185
378806019921	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806019922	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806019923	dimer interface [polypeptide binding]; other site
378806019924	phosphorylation site [posttranslational modification]
378806019925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019926	ATP binding site [chemical binding]; other site
378806019927	Mg2+ binding site [ion binding]; other site
378806019928	G-X-G motif; other site
378806019929	Response regulator receiver domain; Region: Response_reg; pfam00072
378806019930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019931	active site
378806019932	phosphorylation site [posttranslational modification]
378806019933	intermolecular recognition site; other site
378806019934	dimerization interface [polypeptide binding]; other site
378806019935	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806019936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806019937	dimer interface [polypeptide binding]; other site
378806019938	phosphorylation site [posttranslational modification]
378806019939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019940	ATP binding site [chemical binding]; other site
378806019941	Mg2+ binding site [ion binding]; other site
378806019942	G-X-G motif; other site
378806019943	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806019944	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806019945	dimer interface [polypeptide binding]; other site
378806019946	phosphorylation site [posttranslational modification]
378806019947	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
378806019948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019949	ATP binding site [chemical binding]; other site
378806019950	Mg2+ binding site [ion binding]; other site
378806019951	G-X-G motif; other site
378806019952	Response regulator receiver domain; Region: Response_reg; pfam00072
378806019953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806019954	active site
378806019955	phosphorylation site [posttranslational modification]
378806019956	intermolecular recognition site; other site
378806019957	dimerization interface [polypeptide binding]; other site
378806019958	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806019959	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806019960	dimer interface [polypeptide binding]; other site
378806019961	phosphorylation site [posttranslational modification]
378806019962	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806019963	ATP binding site [chemical binding]; other site
378806019964	Mg2+ binding site [ion binding]; other site
378806019965	G-X-G motif; other site
378806019966	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
378806019967	TAP-like protein; Region: Abhydrolase_4; pfam08386
378806019968	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
378806019969	MoaE interaction surface [polypeptide binding]; other site
378806019970	MoeB interaction surface [polypeptide binding]; other site
378806019971	thiocarboxylated glycine; other site
378806019972	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
378806019973	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806019974	motif II; other site
378806019975	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
378806019976	phosphate binding site [ion binding]; other site
378806019977	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806019978	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
378806019979	putative C-terminal domain interface [polypeptide binding]; other site
378806019980	putative GSH binding site (G-site) [chemical binding]; other site
378806019981	putative dimer interface [polypeptide binding]; other site
378806019982	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
378806019983	dimer interface [polypeptide binding]; other site
378806019984	N-terminal domain interface [polypeptide binding]; other site
378806019985	putative substrate binding pocket (H-site) [chemical binding]; other site
378806019986	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
378806019987	Bacterial SH3 domain; Region: SH3_3; pfam08239
378806019988	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806019989	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806019990	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806019991	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806019992	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
378806019993	putative ADP-binding pocket [chemical binding]; other site
378806019994	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806019995	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
378806019996	Chain length determinant protein; Region: Wzz; pfam02706
378806019997	Chain length determinant protein; Region: Wzz; cl15801
378806019998	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806019999	Magnesium ion binding site [ion binding]; other site
378806020000	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
378806020001	Methyltransferase domain; Region: Methyltransf_31; pfam13847
378806020002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806020003	S-adenosylmethionine binding site [chemical binding]; other site
378806020004	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806020005	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
378806020006	putative acyl-acceptor binding pocket; other site
378806020007	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
378806020008	Family description; Region: VCBS; pfam13517
378806020009	Family description; Region: VCBS; pfam13517
378806020010	Family description; Region: VCBS; pfam13517
378806020011	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
378806020012	metal binding site [ion binding]; metal-binding site
378806020013	active site
378806020014	Family description; Region: VCBS; pfam13517
378806020015	Family description; Region: VCBS; pfam13517
378806020016	Family description; Region: VCBS; pfam13517
378806020017	CARDB; Region: CARDB; pfam07705
378806020018	HYR domain; Region: HYR; pfam02494
378806020019	HYR domain; Region: HYR; pfam02494
378806020020	HYR domain; Region: HYR; pfam02494
378806020021	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
378806020022	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806020023	FHA domain; Region: FHA; pfam00498
378806020024	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806020025	GAF domain; Region: GAF_2; pfam13185
378806020026	cyclase homology domain; Region: CHD; cd07302
378806020027	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806020028	nucleotidyl binding site; other site
378806020029	metal binding site [ion binding]; metal-binding site
378806020030	dimer interface [polypeptide binding]; other site
378806020031	PAS domain; Region: PAS; smart00091
378806020032	PAS fold; Region: PAS_4; pfam08448
378806020033	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806020034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020035	dimer interface [polypeptide binding]; other site
378806020036	phosphorylation site [posttranslational modification]
378806020037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020038	ATP binding site [chemical binding]; other site
378806020039	Mg2+ binding site [ion binding]; other site
378806020040	G-X-G motif; other site
378806020041	transcription-repair coupling factor (mfd); Region: mfd; TIGR00580
378806020042	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
378806020043	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806020044	ATP binding site [chemical binding]; other site
378806020045	putative Mg++ binding site [ion binding]; other site
378806020046	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806020047	nucleotide binding region [chemical binding]; other site
378806020048	ATP-binding site [chemical binding]; other site
378806020049	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
378806020050	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806020051	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
378806020052	PA/protease or protease-like domain interface [polypeptide binding]; other site
378806020053	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
378806020054	Zn binding site [ion binding]; other site
378806020055	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
378806020056	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
378806020057	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
378806020058	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
378806020059	Myxococcales GC_trans_RRR domain; Region: GC_trans_RRR; TIGR03382
378806020060	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
378806020061	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
378806020062	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
378806020063	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
378806020064	metal binding site [ion binding]; metal-binding site
378806020065	putative dimer interface [polypeptide binding]; other site
378806020066	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
378806020067	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806020068	active site
378806020069	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
378806020070	dinuclear metal binding motif [ion binding]; other site
378806020071	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
378806020072	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
378806020073	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
378806020074	active site
378806020075	DNA binding site [nucleotide binding]
378806020076	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
378806020077	DNA binding site [nucleotide binding]
378806020078	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
378806020079	nucleotide binding site [chemical binding]; other site
378806020080	FG-GAP repeat; Region: FG-GAP; cl15299
378806020081	Family description; Region: VCBS; pfam13517
378806020082	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
378806020083	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
378806020084	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
378806020085	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
378806020086	Protein of unknown function (DUF420); Region: DUF420; pfam04238
378806020087	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806020088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020089	active site
378806020090	phosphorylation site [posttranslational modification]
378806020091	intermolecular recognition site; other site
378806020092	dimerization interface [polypeptide binding]; other site
378806020093	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806020094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020095	ATP binding site [chemical binding]; other site
378806020096	Mg2+ binding site [ion binding]; other site
378806020097	G-X-G motif; other site
378806020098	Response regulator receiver domain; Region: Response_reg; pfam00072
378806020099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020100	active site
378806020101	phosphorylation site [posttranslational modification]
378806020102	intermolecular recognition site; other site
378806020103	dimerization interface [polypeptide binding]; other site
378806020104	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
378806020105	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806020106	Phytochrome region; Region: PHY; pfam00360
378806020107	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020108	dimer interface [polypeptide binding]; other site
378806020109	phosphorylation site [posttranslational modification]
378806020110	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020111	ATP binding site [chemical binding]; other site
378806020112	Mg2+ binding site [ion binding]; other site
378806020113	G-X-G motif; other site
378806020114	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
378806020115	heme binding pocket [chemical binding]; other site
378806020116	heme ligand [chemical binding]; other site
378806020117	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
378806020118	active site
378806020119	catalytic triad [active]
378806020120	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
378806020121	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806020122	ATP binding site [chemical binding]; other site
378806020123	putative Mg++ binding site [ion binding]; other site
378806020124	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806020125	nucleotide binding region [chemical binding]; other site
378806020126	ATP-binding site [chemical binding]; other site
378806020127	DEAD/H associated; Region: DEAD_assoc; pfam08494
378806020128	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
378806020129	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
378806020130	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
378806020131	dimer interface [polypeptide binding]; other site
378806020132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806020133	catalytic residue [active]
378806020134	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
378806020135	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
378806020136	iron-sulfur cluster [ion binding]; other site
378806020137	[2Fe-2S] cluster binding site [ion binding]; other site
378806020138	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
378806020139	hydrophobic ligand binding site; other site
378806020140	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
378806020141	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
378806020142	Ricin-type beta-trefoil; Region: RICIN; smart00458
378806020143	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806020144	putative sugar binding sites [chemical binding]; other site
378806020145	Q-X-W motif; other site
378806020146	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
378806020147	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806020148	putative active site [active]
378806020149	heme pocket [chemical binding]; other site
378806020150	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806020151	putative active site [active]
378806020152	heme pocket [chemical binding]; other site
378806020153	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806020154	GAF domain; Region: GAF; pfam01590
378806020155	PAS domain S-box; Region: sensory_box; TIGR00229
378806020156	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806020157	putative active site [active]
378806020158	heme pocket [chemical binding]; other site
378806020159	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806020160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020161	ATP binding site [chemical binding]; other site
378806020162	Mg2+ binding site [ion binding]; other site
378806020163	G-X-G motif; other site
378806020164	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806020165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020166	active site
378806020167	phosphorylation site [posttranslational modification]
378806020168	intermolecular recognition site; other site
378806020169	dimerization interface [polypeptide binding]; other site
378806020170	Response regulator receiver domain; Region: Response_reg; pfam00072
378806020171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020172	active site
378806020173	phosphorylation site [posttranslational modification]
378806020174	intermolecular recognition site; other site
378806020175	dimerization interface [polypeptide binding]; other site
378806020176	Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226
378806020177	putative active site [active]
378806020178	Zn binding site [ion binding]; other site
378806020179	Uncharacterized conserved protein [Function unknown]; Region: COG3350
378806020180	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
378806020181	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
378806020182	Soluble P-type ATPase [General function prediction only]; Region: COG4087
378806020183	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
378806020184	active site
378806020185	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806020186	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
378806020187	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
378806020188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806020189	active site
378806020190	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020191	active site
378806020192	ATP binding site [chemical binding]; other site
378806020193	substrate binding site [chemical binding]; other site
378806020194	activation loop (A-loop); other site
378806020195	Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282
378806020196	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
378806020197	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
378806020198	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
378806020199	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
378806020200	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
378806020201	putative active site [active]
378806020202	Zn binding site [ion binding]; other site
378806020203	PilZ domain; Region: PilZ; cl01260
378806020204	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
378806020205	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
378806020206	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806020207	Walker A/P-loop; other site
378806020208	ATP binding site [chemical binding]; other site
378806020209	Q-loop/lid; other site
378806020210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806020211	Q-loop/lid; other site
378806020212	ABC transporter signature motif; other site
378806020213	Walker B; other site
378806020214	D-loop; other site
378806020215	H-loop/switch region; other site
378806020216	exonuclease subunit SbcD; Provisional; Region: PRK10966
378806020217	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
378806020218	active site
378806020219	metal binding site [ion binding]; metal-binding site
378806020220	DNA binding site [nucleotide binding]
378806020221	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
378806020222	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806020223	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
378806020224	putative acyl-acceptor binding pocket; other site
378806020225	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
378806020226	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806020227	NAD(P) binding site [chemical binding]; other site
378806020228	active site
378806020229	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
378806020230	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
378806020231	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
378806020232	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
378806020233	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
378806020234	putative active site [active]
378806020235	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
378806020236	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
378806020237	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
378806020238	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
378806020239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020240	active site
378806020241	phosphorylation site [posttranslational modification]
378806020242	intermolecular recognition site; other site
378806020243	dimerization interface [polypeptide binding]; other site
378806020244	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
378806020245	DNA binding site [nucleotide binding]
378806020246	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806020247	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806020248	dimerization interface [polypeptide binding]; other site
378806020249	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020250	dimer interface [polypeptide binding]; other site
378806020251	phosphorylation site [posttranslational modification]
378806020252	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020253	ATP binding site [chemical binding]; other site
378806020254	G-X-G motif; other site
378806020255	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806020256	GAF domain; Region: GAF; pfam01590
378806020257	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806020258	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020259	dimer interface [polypeptide binding]; other site
378806020260	phosphorylation site [posttranslational modification]
378806020261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020262	ATP binding site [chemical binding]; other site
378806020263	Mg2+ binding site [ion binding]; other site
378806020264	G-X-G motif; other site
378806020265	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020266	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806020267	active site
378806020268	ATP binding site [chemical binding]; other site
378806020269	substrate binding site [chemical binding]; other site
378806020270	activation loop (A-loop); other site
378806020271	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806020272	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806020273	DNA-binding site [nucleotide binding]; DNA binding site
378806020274	Protein of unknown function (DUF2379); Region: DUF2379; cl15283
378806020275	Protein of unknown function (DUF2379); Region: DUF2379; cl15283
378806020276	Predicted transcriptional regulator [Transcription]; Region: COG2378
378806020277	HTH domain; Region: HTH_11; pfam08279
378806020278	WYL domain; Region: WYL; pfam13280
378806020279	RibD C-terminal domain; Region: RibD_C; cl17279
378806020280	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
378806020281	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
378806020282	active site
378806020283	acyl-activating enzyme (AAE) consensus motif; other site
378806020284	putative CoA binding site [chemical binding]; other site
378806020285	AMP binding site [chemical binding]; other site
378806020286	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
378806020287	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
378806020288	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806020289	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020290	active site
378806020291	ATP binding site [chemical binding]; other site
378806020292	substrate binding site [chemical binding]; other site
378806020293	activation loop (A-loop); other site
378806020294	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806020295	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
378806020296	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806020297	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806020298	phosphopeptide binding site; other site
378806020299	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806020300	PAS fold; Region: PAS_3; pfam08447
378806020301	putative active site [active]
378806020302	heme pocket [chemical binding]; other site
378806020303	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806020304	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806020305	putative active site [active]
378806020306	heme pocket [chemical binding]; other site
378806020307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020308	dimer interface [polypeptide binding]; other site
378806020309	phosphorylation site [posttranslational modification]
378806020310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020311	ATP binding site [chemical binding]; other site
378806020312	Mg2+ binding site [ion binding]; other site
378806020313	G-X-G motif; other site
378806020314	Response regulator receiver domain; Region: Response_reg; pfam00072
378806020315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020316	active site
378806020317	phosphorylation site [posttranslational modification]
378806020318	intermolecular recognition site; other site
378806020319	dimerization interface [polypeptide binding]; other site
378806020320	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806020321	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020322	active site
378806020323	ATP binding site [chemical binding]; other site
378806020324	substrate binding site [chemical binding]; other site
378806020325	activation loop (A-loop); other site
378806020326	benzoate transport; Region: 2A0115; TIGR00895
378806020327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806020328	putative substrate translocation pore; other site
378806020329	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
378806020330	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
378806020331	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
378806020332	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806020333	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806020334	calcium binding site 2 [ion binding]; other site
378806020335	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806020336	active site
378806020337	catalytic triad [active]
378806020338	calcium binding site 1 [ion binding]; other site
378806020339	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
378806020340	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
378806020341	DNA binding residues [nucleotide binding]
378806020342	B12 binding domain; Region: B12-binding_2; pfam02607
378806020343	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
378806020344	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
378806020345	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
378806020346	DNA binding residues [nucleotide binding]
378806020347	B12 binding domain; Region: B12-binding_2; pfam02607
378806020348	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
378806020349	B12 binding site [chemical binding]; other site
378806020350	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
378806020351	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
378806020352	putative acyl-acceptor binding pocket; other site
378806020353	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
378806020354	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
378806020355	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
378806020356	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
378806020357	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
378806020358	phytoene desaturase; Region: crtI_fam; TIGR02734
378806020359	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
378806020360	active site lid residues [active]
378806020361	substrate binding pocket [chemical binding]; other site
378806020362	catalytic residues [active]
378806020363	substrate-Mg2+ binding site; other site
378806020364	aspartate-rich region 1; other site
378806020365	aspartate-rich region 2; other site
378806020366	phytoene desaturase; Region: crtI_fam; TIGR02734
378806020367	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
378806020368	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
378806020369	substrate binding pocket [chemical binding]; other site
378806020370	chain length determination region; other site
378806020371	substrate-Mg2+ binding site; other site
378806020372	catalytic residues [active]
378806020373	aspartate-rich region 1; other site
378806020374	active site lid residues [active]
378806020375	aspartate-rich region 2; other site
378806020376	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
378806020377	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
378806020378	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
378806020379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020380	dimer interface [polypeptide binding]; other site
378806020381	phosphorylation site [posttranslational modification]
378806020382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020383	ATP binding site [chemical binding]; other site
378806020384	Mg2+ binding site [ion binding]; other site
378806020385	G-X-G motif; other site
378806020386	Response regulator receiver domain; Region: Response_reg; pfam00072
378806020387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020388	active site
378806020389	phosphorylation site [posttranslational modification]
378806020390	intermolecular recognition site; other site
378806020391	dimerization interface [polypeptide binding]; other site
378806020392	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806020393	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
378806020394	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
378806020395	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
378806020396	NADP binding site [chemical binding]; other site
378806020397	phosphodiesterase YaeI; Provisional; Region: PRK11340
378806020398	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
378806020399	putative active site [active]
378806020400	putative metal binding site [ion binding]; other site
378806020401	Bacterial SH3 domain; Region: SH3_3; pfam08239
378806020402	Domain of unknown function (DUF4215); Region: DUF4215; pfam13948
378806020403	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806020404	Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232
378806020405	Domain of unknown function (DUF4215); Region: DUF4215; pfam13948
378806020406	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
378806020407	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806020408	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806020409	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
378806020410	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
378806020411	generic binding surface I; other site
378806020412	generic binding surface II; other site
378806020413	Lamin Tail Domain; Region: LTD; pfam00932
378806020414	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806020415	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020416	active site
378806020417	ATP binding site [chemical binding]; other site
378806020418	substrate binding site [chemical binding]; other site
378806020419	activation loop (A-loop); other site
378806020420	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806020421	phosphopeptide binding site; other site
378806020422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806020423	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806020424	binding surface
378806020425	TPR motif; other site
378806020426	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806020427	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806020428	active site
378806020429	ATP binding site [chemical binding]; other site
378806020430	substrate binding site [chemical binding]; other site
378806020431	activation loop (A-loop); other site
378806020432	PEGA domain; Region: PEGA; pfam08308
378806020433	hypothetical protein; Provisional; Region: PRK07338
378806020434	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
378806020435	metal binding site [ion binding]; metal-binding site
378806020436	dimer interface [polypeptide binding]; other site
378806020437	Protein required for attachment to host cells; Region: Host_attach; pfam10116
378806020438	HAMP domain; Region: HAMP; pfam00672
378806020439	dimerization interface [polypeptide binding]; other site
378806020440	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806020441	dimer interface [polypeptide binding]; other site
378806020442	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
378806020443	putative CheW interface [polypeptide binding]; other site
378806020444	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
378806020445	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806020446	motif II; other site
378806020447	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
378806020448	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806020449	putative C-terminal domain interface [polypeptide binding]; other site
378806020450	putative GSH binding site (G-site) [chemical binding]; other site
378806020451	putative dimer interface [polypeptide binding]; other site
378806020452	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
378806020453	putative N-terminal domain interface [polypeptide binding]; other site
378806020454	putative dimer interface [polypeptide binding]; other site
378806020455	putative substrate binding pocket (H-site) [chemical binding]; other site
378806020456	cyclase homology domain; Region: CHD; cd07302
378806020457	dimer interface [polypeptide binding]; other site
378806020458	nucleotidyl binding site; other site
378806020459	metal binding site [ion binding]; metal-binding site
378806020460	PGAP1-like protein; Region: PGAP1; pfam07819
378806020461	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
378806020462	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
378806020463	dimerization interface [polypeptide binding]; other site
378806020464	DPS ferroxidase diiron center [ion binding]; other site
378806020465	ion pore; other site
378806020466	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
378806020467	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
378806020468	C-terminal domain interface [polypeptide binding]; other site
378806020469	GSH binding site (G-site) [chemical binding]; other site
378806020470	dimer interface [polypeptide binding]; other site
378806020471	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
378806020472	dimer interface [polypeptide binding]; other site
378806020473	N-terminal domain interface [polypeptide binding]; other site
378806020474	Uncharacterized conserved protein [Function unknown]; Region: COG0397
378806020475	hypothetical protein; Validated; Region: PRK00029
378806020476	Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719
378806020477	dimer interface [polypeptide binding]; other site
378806020478	substrate binding site [chemical binding]; other site
378806020479	metal binding sites [ion binding]; metal-binding site
378806020480	CHAD domain; Region: CHAD; pfam05235
378806020481	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
378806020482	putative chaperone; Provisional; Region: PRK11678
378806020483	nucleotide binding site [chemical binding]; other site
378806020484	putative NEF/HSP70 interaction site [polypeptide binding]; other site
378806020485	SBD interface [polypeptide binding]; other site
378806020486	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
378806020487	CheB methylesterase; Region: CheB_methylest; pfam01339
378806020488	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
378806020489	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
378806020490	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
378806020491	PAS domain; Region: PAS_10; pfam13596
378806020492	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806020493	putative active site [active]
378806020494	heme pocket [chemical binding]; other site
378806020495	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806020496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020497	dimer interface [polypeptide binding]; other site
378806020498	phosphorylation site [posttranslational modification]
378806020499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020500	ATP binding site [chemical binding]; other site
378806020501	Mg2+ binding site [ion binding]; other site
378806020502	G-X-G motif; other site
378806020503	Response regulator receiver domain; Region: Response_reg; pfam00072
378806020504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020505	active site
378806020506	phosphorylation site [posttranslational modification]
378806020507	intermolecular recognition site; other site
378806020508	dimerization interface [polypeptide binding]; other site
378806020509	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
378806020510	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020511	dimer interface [polypeptide binding]; other site
378806020512	phosphorylation site [posttranslational modification]
378806020513	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
378806020514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020515	ATP binding site [chemical binding]; other site
378806020516	Mg2+ binding site [ion binding]; other site
378806020517	G-X-G motif; other site
378806020518	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
378806020519	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
378806020520	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
378806020521	active site
378806020522	catalytic site [active]
378806020523	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
378806020524	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
378806020525	catalytic residues [active]
378806020526	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
378806020527	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020528	active site
378806020529	ATP binding site [chemical binding]; other site
378806020530	substrate binding site [chemical binding]; other site
378806020531	activation loop (A-loop); other site
378806020532	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
378806020533	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
378806020534	ATP binding site [chemical binding]; other site
378806020535	Mg++ binding site [ion binding]; other site
378806020536	motif III; other site
378806020537	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806020538	nucleotide binding region [chemical binding]; other site
378806020539	ATP-binding site [chemical binding]; other site
378806020540	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
378806020541	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
378806020542	putative dimer interface [polypeptide binding]; other site
378806020543	putative anticodon binding site; other site
378806020544	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
378806020545	homodimer interface [polypeptide binding]; other site
378806020546	motif 1; other site
378806020547	motif 2; other site
378806020548	active site
378806020549	motif 3; other site
378806020550	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
378806020551	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806020552	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806020553	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806020554	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806020555	ligand binding site [chemical binding]; other site
378806020556	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
378806020557	SnoaL-like domain; Region: SnoaL_3; pfam13474
378806020558	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806020559	Putative serine esterase (DUF676); Region: DUF676; pfam05057
378806020560	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
378806020561	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
378806020562	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
378806020563	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
378806020564	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
378806020565	Ca binding site [ion binding]; other site
378806020566	active site
378806020567	catalytic site [active]
378806020568	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
378806020569	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
378806020570	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
378806020571	active site
378806020572	catalytic site [active]
378806020573	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
378806020574	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
378806020575	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
378806020576	Walker A/P-loop; other site
378806020577	ATP binding site [chemical binding]; other site
378806020578	Q-loop/lid; other site
378806020579	ABC transporter signature motif; other site
378806020580	Walker B; other site
378806020581	D-loop; other site
378806020582	H-loop/switch region; other site
378806020583	TOBE domain; Region: TOBE_2; pfam08402
378806020584	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
378806020585	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
378806020586	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
378806020587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
378806020588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806020589	dimer interface [polypeptide binding]; other site
378806020590	conserved gate region; other site
378806020591	putative PBP binding loops; other site
378806020592	ABC-ATPase subunit interface; other site
378806020593	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
378806020594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806020595	dimer interface [polypeptide binding]; other site
378806020596	conserved gate region; other site
378806020597	putative PBP binding loops; other site
378806020598	ABC-ATPase subunit interface; other site
378806020599	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
378806020600	putative ligand binding site [chemical binding]; other site
378806020601	Endonuclease I; Region: Endonuclease_1; pfam04231
378806020602	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806020603	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806020604	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806020605	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806020606	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
378806020607	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
378806020608	Ligand Binding Site [chemical binding]; other site
378806020609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806020610	binding surface
378806020611	TPR motif; other site
378806020612	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806020613	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020614	active site
378806020615	ATP binding site [chemical binding]; other site
378806020616	substrate binding site [chemical binding]; other site
378806020617	activation loop (A-loop); other site
378806020618	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806020619	cyclase homology domain; Region: CHD; cd07302
378806020620	nucleotidyl binding site; other site
378806020621	metal binding site [ion binding]; metal-binding site
378806020622	dimer interface [polypeptide binding]; other site
378806020623	HEAT repeats; Region: HEAT_2; pfam13646
378806020624	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806020625	PAS domain; Region: PAS_9; pfam13426
378806020626	putative active site [active]
378806020627	heme pocket [chemical binding]; other site
378806020628	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020629	dimer interface [polypeptide binding]; other site
378806020630	phosphorylation site [posttranslational modification]
378806020631	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020632	ATP binding site [chemical binding]; other site
378806020633	Mg2+ binding site [ion binding]; other site
378806020634	G-X-G motif; other site
378806020635	Response regulator receiver domain; Region: Response_reg; pfam00072
378806020636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020637	active site
378806020638	phosphorylation site [posttranslational modification]
378806020639	intermolecular recognition site; other site
378806020640	dimerization interface [polypeptide binding]; other site
378806020641	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806020642	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
378806020643	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
378806020644	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
378806020645	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
378806020646	active site
378806020647	Zn binding site [ion binding]; other site
378806020648	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
378806020649	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
378806020650	potential catalytic triad [active]
378806020651	conserved cys residue [active]
378806020652	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806020653	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806020654	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
378806020655	dimerization interface [polypeptide binding]; other site
378806020656	short chain dehydrogenase; Provisional; Region: PRK08278
378806020657	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
378806020658	NAD(P) binding site [chemical binding]; other site
378806020659	homodimer interface [polypeptide binding]; other site
378806020660	active site
378806020661	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806020662	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020663	active site
378806020664	ATP binding site [chemical binding]; other site
378806020665	substrate binding site [chemical binding]; other site
378806020666	activation loop (A-loop); other site
378806020667	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
378806020668	Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791
378806020669	active site
378806020670	zinc binding site [ion binding]; other site
378806020671	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
378806020672	nucleotide binding site [chemical binding]; other site
378806020673	substrate binding site [chemical binding]; other site
378806020674	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
378806020675	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
378806020676	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
378806020677	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806020678	Coenzyme A binding pocket [chemical binding]; other site
378806020679	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
378806020680	endonuclease III; Region: ENDO3c; smart00478
378806020681	minor groove reading motif; other site
378806020682	helix-hairpin-helix signature motif; other site
378806020683	substrate binding pocket [chemical binding]; other site
378806020684	active site
378806020685	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
378806020686	PLD-like domain; Region: PLDc_2; pfam13091
378806020687	putative active site [active]
378806020688	catalytic site [active]
378806020689	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
378806020690	PLD-like domain; Region: PLDc_2; pfam13091
378806020691	putative active site [active]
378806020692	catalytic site [active]
378806020693	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806020694	acyl-coenzyme A oxidase; Region: PLN02636
378806020695	active site
378806020696	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
378806020697	Clp protease; Region: CLP_protease; pfam00574
378806020698	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
378806020699	oligomer interface [polypeptide binding]; other site
378806020700	active site residues [active]
378806020701	Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171
378806020702	PLD-like domain; Region: PLDc_2; pfam13091
378806020703	putative active site [active]
378806020704	catalytic site [active]
378806020705	fumarate hydratase; Reviewed; Region: fumC; PRK00485
378806020706	Class II fumarases; Region: Fumarase_classII; cd01362
378806020707	active site
378806020708	tetramer interface [polypeptide binding]; other site
378806020709	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
378806020710	heat shock protein HtpX; Provisional; Region: PRK05457
378806020711	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
378806020712	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
378806020713	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806020714	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
378806020715	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
378806020716	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
378806020717	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
378806020718	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806020719	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806020720	phosphopeptide binding site; other site
378806020721	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
378806020722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806020723	Walker A motif; other site
378806020724	ATP binding site [chemical binding]; other site
378806020725	Walker B motif; other site
378806020726	arginine finger; other site
378806020727	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806020728	Protein kinase domain; Region: Pkinase; pfam00069
378806020729	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020730	active site
378806020731	ATP binding site [chemical binding]; other site
378806020732	substrate binding site [chemical binding]; other site
378806020733	activation loop (A-loop); other site
378806020734	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
378806020735	putative active site [active]
378806020736	PspC domain; Region: PspC; pfam04024
378806020737	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
378806020738	malate synthase A; Region: malate_syn_A; TIGR01344
378806020739	active site
378806020740	isocitrate lyase; Provisional; Region: PRK15063
378806020741	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
378806020742	tetramer interface [polypeptide binding]; other site
378806020743	active site
378806020744	Mg2+/Mn2+ binding site [ion binding]; other site
378806020745	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
378806020746	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
378806020747	B12 binding site [chemical binding]; other site
378806020748	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806020749	FeS/SAM binding site; other site
378806020750	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
378806020751	putative active site [active]
378806020752	tyrosine decarboxylase; Region: PLN02880
378806020753	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806020754	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806020755	catalytic residue [active]
378806020756	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
378806020757	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
378806020758	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
378806020759	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806020760	dimer interface [polypeptide binding]; other site
378806020761	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806020762	putative CheW interface [polypeptide binding]; other site
378806020763	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806020764	dimer interface [polypeptide binding]; other site
378806020765	putative CheW interface [polypeptide binding]; other site
378806020766	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
378806020767	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
378806020768	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
378806020769	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020770	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806020771	active site
378806020772	ATP binding site [chemical binding]; other site
378806020773	substrate binding site [chemical binding]; other site
378806020774	activation loop (A-loop); other site
378806020775	Response regulator receiver domain; Region: Response_reg; pfam00072
378806020776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020777	active site
378806020778	phosphorylation site [posttranslational modification]
378806020779	intermolecular recognition site; other site
378806020780	dimerization interface [polypeptide binding]; other site
378806020781	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806020782	cyclase homology domain; Region: CHD; cd07302
378806020783	nucleotidyl binding site; other site
378806020784	metal binding site [ion binding]; metal-binding site
378806020785	dimer interface [polypeptide binding]; other site
378806020786	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806020787	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806020788	phosphopeptide binding site; other site
378806020789	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806020790	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806020791	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806020792	cyclase homology domain; Region: CHD; cd07302
378806020793	nucleotidyl binding site; other site
378806020794	metal binding site [ion binding]; metal-binding site
378806020795	dimer interface [polypeptide binding]; other site
378806020796	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806020797	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
378806020798	ligand binding site [chemical binding]; other site
378806020799	flexible hinge region; other site
378806020800	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
378806020801	putative switch regulator; other site
378806020802	non-specific DNA interactions [nucleotide binding]; other site
378806020803	DNA binding site [nucleotide binding]
378806020804	sequence specific DNA binding site [nucleotide binding]; other site
378806020805	putative cAMP binding site [chemical binding]; other site
378806020806	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806020807	binding surface
378806020808	TPR repeat; Region: TPR_11; pfam13414
378806020809	TPR motif; other site
378806020810	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806020811	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806020812	ligand binding site [chemical binding]; other site
378806020813	flexible hinge region; other site
378806020814	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
378806020815	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
378806020816	ligand binding site [chemical binding]; other site
378806020817	flexible hinge region; other site
378806020818	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
378806020819	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806020820	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
378806020821	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806020822	dimer interface [polypeptide binding]; other site
378806020823	phosphorylation site [posttranslational modification]
378806020824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020825	ATP binding site [chemical binding]; other site
378806020826	Mg2+ binding site [ion binding]; other site
378806020827	G-X-G motif; other site
378806020828	Response regulator receiver domain; Region: Response_reg; pfam00072
378806020829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020830	active site
378806020831	phosphorylation site [posttranslational modification]
378806020832	intermolecular recognition site; other site
378806020833	dimerization interface [polypeptide binding]; other site
378806020834	Response regulator receiver domain; Region: Response_reg; pfam00072
378806020835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806020836	active site
378806020837	phosphorylation site [posttranslational modification]
378806020838	intermolecular recognition site; other site
378806020839	dimerization interface [polypeptide binding]; other site
378806020840	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806020841	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806020842	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470
378806020843	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806020844	FeS/SAM binding site; other site
378806020845	Putative zinc-finger; Region: zf-HC2; pfam13490
378806020846	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806020847	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806020848	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806020849	DNA binding residues [nucleotide binding]
378806020850	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
378806020851	active site
378806020852	DNA binding site [nucleotide binding]
378806020853	hypothetical protein; Provisional; Region: PRK08244
378806020854	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806020855	tetracycline repressor protein TetR; Provisional; Region: PRK13756
378806020856	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806020857	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
378806020858	4-alpha-glucanotransferase; Provisional; Region: PRK14508
378806020859	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806020860	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
378806020861	Surface antigen; Region: Bac_surface_Ag; pfam01103
378806020862	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
378806020863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
378806020864	Family of unknown function (DUF490); Region: DUF490; pfam04357
378806020865	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
378806020866	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
378806020867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
378806020868	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
378806020869	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
378806020870	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
378806020871	metal ion-dependent adhesion site (MIDAS); other site
378806020872	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806020873	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806020874	active site
378806020875	ATP binding site [chemical binding]; other site
378806020876	substrate binding site [chemical binding]; other site
378806020877	activation loop (A-loop); other site
378806020878	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
378806020879	Protein of unknown function DUF58; Region: DUF58; pfam01882
378806020880	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
378806020881	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806020882	Walker A/P-loop; other site
378806020883	ATP binding site [chemical binding]; other site
378806020884	Q-loop/lid; other site
378806020885	ABC transporter signature motif; other site
378806020886	Walker B; other site
378806020887	D-loop; other site
378806020888	H-loop/switch region; other site
378806020889	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806020890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806020891	Walker A motif; other site
378806020892	ATP binding site [chemical binding]; other site
378806020893	Walker B motif; other site
378806020894	arginine finger; other site
378806020895	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
378806020896	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
378806020897	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
378806020898	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
378806020899	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806020900	Transcriptional regulators [Transcription]; Region: MarR; COG1846
378806020901	MarR family; Region: MarR; pfam01047
378806020902	Protein of unknown function, DUF547; Region: DUF547; pfam04784
378806020903	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
378806020904	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
378806020905	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
378806020906	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
378806020907	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
378806020908	TM-ABC transporter signature motif; other site
378806020909	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
378806020910	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806020911	Walker A/P-loop; other site
378806020912	ATP binding site [chemical binding]; other site
378806020913	Q-loop/lid; other site
378806020914	ABC transporter signature motif; other site
378806020915	Walker B; other site
378806020916	D-loop; other site
378806020917	H-loop/switch region; other site
378806020918	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
378806020919	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
378806020920	putative ligand binding site [chemical binding]; other site
378806020921	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
378806020922	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806020923	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806020924	NAD(P) binding site [chemical binding]; other site
378806020925	active site
378806020926	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806020927	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806020928	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
378806020929	putative effector binding pocket; other site
378806020930	dimerization interface [polypeptide binding]; other site
378806020931	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
378806020932	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806020933	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
378806020934	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
378806020935	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
378806020936	active site
378806020937	substrate binding site [chemical binding]; other site
378806020938	metal binding site [ion binding]; metal-binding site
378806020939	Glycine-rich protein domain (DUF2403); Region: DUF2403; pfam10290
378806020940	Putative TOS1-like glycosyl hydrolase (DUF2401); Region: DUF2401; pfam10287
378806020941	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806020942	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806020943	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806020944	putative active site [active]
378806020945	heme pocket [chemical binding]; other site
378806020946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806020947	ATP binding site [chemical binding]; other site
378806020948	Mg2+ binding site [ion binding]; other site
378806020949	G-X-G motif; other site
378806020950	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
378806020951	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
378806020952	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
378806020953	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
378806020954	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
378806020955	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
378806020956	homodimer interface [polypeptide binding]; other site
378806020957	substrate-cofactor binding pocket; other site
378806020958	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806020959	catalytic residue [active]
378806020960	CotH protein; Region: CotH; pfam08757
378806020961	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
378806020962	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
378806020963	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
378806020964	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
378806020965	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806020966	motif II; other site
378806020967	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
378806020968	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806020969	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806020970	active site
378806020971	ATP binding site [chemical binding]; other site
378806020972	substrate binding site [chemical binding]; other site
378806020973	activation loop (A-loop); other site
378806020974	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
378806020975	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
378806020976	Cytochrome P450; Region: p450; cl12078
378806020977	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
378806020978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806020979	dimer interface [polypeptide binding]; other site
378806020980	conserved gate region; other site
378806020981	putative PBP binding loops; other site
378806020982	ABC-ATPase subunit interface; other site
378806020983	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
378806020984	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806020985	Walker A/P-loop; other site
378806020986	ATP binding site [chemical binding]; other site
378806020987	Q-loop/lid; other site
378806020988	ABC transporter signature motif; other site
378806020989	Walker B; other site
378806020990	D-loop; other site
378806020991	H-loop/switch region; other site
378806020992	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
378806020993	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
378806020994	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
378806020995	ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185
378806020996	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806020997	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
378806020998	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806020999	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
378806021000	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
378806021001	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806021002	sugar binding site [chemical binding]; other site
378806021003	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806021004	sugar binding site [chemical binding]; other site
378806021005	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806021006	sugar binding site [chemical binding]; other site
378806021007	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
378806021008	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
378806021009	G1 box; other site
378806021010	GTP/Mg2+ binding site [chemical binding]; other site
378806021011	G2 box; other site
378806021012	Switch I region; other site
378806021013	G3 box; other site
378806021014	Switch II region; other site
378806021015	G4 box; other site
378806021016	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
378806021017	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
378806021018	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806021019	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021020	active site
378806021021	ATP binding site [chemical binding]; other site
378806021022	substrate binding site [chemical binding]; other site
378806021023	activation loop (A-loop); other site
378806021024	Putative exonuclease, RdgC; Region: RdgC; cl01122
378806021025	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
378806021026	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
378806021027	YCII-related domain; Region: YCII; cl00999
378806021028	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
378806021029	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806021030	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
378806021031	DNA binding residues [nucleotide binding]
378806021032	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
378806021033	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
378806021034	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
378806021035	active site
378806021036	HIGH motif; other site
378806021037	KMSK motif region; other site
378806021038	tRNA binding surface [nucleotide binding]; other site
378806021039	DALR anticodon binding domain; Region: DALR_1; smart00836
378806021040	anticodon binding site; other site
378806021041	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
378806021042	Putative esterase; Region: Esterase; pfam00756
378806021043	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
378806021044	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
378806021045	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
378806021046	Substrate binding site; other site
378806021047	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
378806021048	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
378806021049	active site
378806021050	oxyanion hole [active]
378806021051	catalytic triad [active]
378806021052	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
378806021053	active site
378806021054	catalytic triad [active]
378806021055	oxyanion hole [active]
378806021056	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
378806021057	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
378806021058	putative active site [active]
378806021059	putative CoA binding site [chemical binding]; other site
378806021060	nudix motif; other site
378806021061	metal binding site [ion binding]; metal-binding site
378806021062	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
378806021063	hypothetical protein; Provisional; Region: PRK01842
378806021064	SEC-C motif; Region: SEC-C; pfam02810
378806021065	S-adenosylmethionine synthetase; Validated; Region: PRK05250
378806021066	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
378806021067	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
378806021068	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
378806021069	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
378806021070	Site-specific recombinase; Region: SpecificRecomb; pfam10136
378806021071	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
378806021072	MgtC family; Region: MgtC; pfam02308
378806021073	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
378806021074	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
378806021075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806021076	Walker A/P-loop; other site
378806021077	ATP binding site [chemical binding]; other site
378806021078	Q-loop/lid; other site
378806021079	ABC transporter signature motif; other site
378806021080	Walker B; other site
378806021081	D-loop; other site
378806021082	H-loop/switch region; other site
378806021083	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
378806021084	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
378806021085	N-terminal plug; other site
378806021086	ligand-binding site [chemical binding]; other site
378806021087	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
378806021088	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
378806021089	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
378806021090	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
378806021091	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
378806021092	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
378806021093	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
378806021094	intersubunit interface [polypeptide binding]; other site
378806021095	FecCD transport family; Region: FecCD; pfam01032
378806021096	dimer interface [polypeptide binding]; other site
378806021097	putative PBP binding regions; other site
378806021098	ABC-ATPase subunit  interface; other site
378806021099	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
378806021100	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
378806021101	Walker A/P-loop; other site
378806021102	ATP binding site [chemical binding]; other site
378806021103	Q-loop/lid; other site
378806021104	ABC transporter signature motif; other site
378806021105	Walker B; other site
378806021106	D-loop; other site
378806021107	H-loop/switch region; other site
378806021108	Transcriptional regulators [Transcription]; Region: MarR; COG1846
378806021109	MarR family; Region: MarR; pfam01047
378806021110	CotH protein; Region: CotH; pfam08757
378806021111	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037
378806021112	ligand binding surface [chemical binding]; other site
378806021113	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
378806021114	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
378806021115	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
378806021116	homodimer interface [polypeptide binding]; other site
378806021117	NADP binding site [chemical binding]; other site
378806021118	substrate binding site [chemical binding]; other site
378806021119	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
378806021120	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
378806021121	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
378806021122	Putative ammonia monooxygenase; Region: AmoA; pfam05145
378806021123	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
378806021124	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806021125	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021126	active site
378806021127	ATP binding site [chemical binding]; other site
378806021128	substrate binding site [chemical binding]; other site
378806021129	activation loop (A-loop); other site
378806021130	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
378806021131	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
378806021132	substrate binding pocket [chemical binding]; other site
378806021133	catalytic triad [active]
378806021134	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806021135	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806021136	DNA-binding site [nucleotide binding]; DNA binding site
378806021137	TPR repeat; Region: TPR_11; pfam13414
378806021138	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806021139	binding surface
378806021140	TPR motif; other site
378806021141	TPR repeat; Region: TPR_11; pfam13414
378806021142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806021143	TPR motif; other site
378806021144	binding surface
378806021145	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
378806021146	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
378806021147	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806021148	potential frameshift: common BLAST hit: gi|108759376|ref|YP_631754.1| M36 family peptidase
378806021149	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
378806021150	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
378806021151	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
378806021152	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
378806021153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
378806021154	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
378806021155	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
378806021156	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
378806021157	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
378806021158	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
378806021159	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
378806021160	dimerization domain swap beta strand [polypeptide binding]; other site
378806021161	regulatory protein interface [polypeptide binding]; other site
378806021162	active site
378806021163	regulatory phosphorylation site [posttranslational modification]; other site
378806021164	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
378806021165	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
378806021166	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
378806021167	active site
378806021168	phosphorylation site [posttranslational modification]
378806021169	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
378806021170	active pocket/dimerization site; other site
378806021171	active site
378806021172	phosphorylation site [posttranslational modification]
378806021173	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021174	dimerization interface [polypeptide binding]; other site
378806021175	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
378806021176	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
378806021177	dimer interface [polypeptide binding]; other site
378806021178	putative CheW interface [polypeptide binding]; other site
378806021179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806021180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806021181	S-adenosylmethionine binding site [chemical binding]; other site
378806021182	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
378806021183	AAA domain; Region: AAA_18; pfam13238
378806021184	HPr kinase/phosphorylase; Provisional; Region: PRK05428
378806021185	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
378806021186	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
378806021187	Hpr binding site; other site
378806021188	active site
378806021189	homohexamer subunit interaction site [polypeptide binding]; other site
378806021190	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
378806021191	nucleotide binding site/active site [active]
378806021192	HIT family signature motif; other site
378806021193	catalytic residue [active]
378806021194	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
378806021195	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806021196	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
378806021197	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
378806021198	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
378806021199	Cl- selectivity filter; other site
378806021200	Cl- binding residues [ion binding]; other site
378806021201	pore gating glutamate residue; other site
378806021202	dimer interface [polypeptide binding]; other site
378806021203	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
378806021204	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
378806021205	Walker A/P-loop; other site
378806021206	ATP binding site [chemical binding]; other site
378806021207	Q-loop/lid; other site
378806021208	ABC transporter signature motif; other site
378806021209	Walker B; other site
378806021210	D-loop; other site
378806021211	H-loop/switch region; other site
378806021212	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806021213	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021214	active site
378806021215	ATP binding site [chemical binding]; other site
378806021216	substrate binding site [chemical binding]; other site
378806021217	activation loop (A-loop); other site
378806021218	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806021219	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806021220	phosphopeptide binding site; other site
378806021221	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806021222	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
378806021223	cyclase homology domain; Region: CHD; cd07302
378806021224	nucleotidyl binding site; other site
378806021225	metal binding site [ion binding]; metal-binding site
378806021226	dimer interface [polypeptide binding]; other site
378806021227	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
378806021228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
378806021229	Uncharacterized conserved protein [Function unknown]; Region: COG5649
378806021230	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806021231	dimerization interface [polypeptide binding]; other site
378806021232	putative DNA binding site [nucleotide binding]; other site
378806021233	putative Zn2+ binding site [ion binding]; other site
378806021234	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
378806021235	putative hydrophobic ligand binding site [chemical binding]; other site
378806021236	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806021237	Walker A/P-loop; other site
378806021238	ATP binding site [chemical binding]; other site
378806021239	Q-loop/lid; other site
378806021240	ABC transporter signature motif; other site
378806021241	Walker B; other site
378806021242	D-loop; other site
378806021243	H-loop/switch region; other site
378806021244	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
378806021245	putative transposase OrfB; Reviewed; Region: PHA02517
378806021246	HTH-like domain; Region: HTH_21; pfam13276
378806021247	Integrase core domain; Region: rve; pfam00665
378806021248	Integrase core domain; Region: rve_3; pfam13683
378806021249	Transposase; Region: HTH_Tnp_1; pfam01527
378806021250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
378806021251	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
378806021252	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
378806021253	Transposase domain (DUF772); Region: DUF772; pfam05598
378806021254	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806021255	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
378806021256	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
378806021257	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
378806021258	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
378806021259	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806021260	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806021261	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
378806021262	Superfamily II helicase [General function prediction only]; Region: COG1204
378806021263	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806021264	ATP binding site [chemical binding]; other site
378806021265	putative Mg++ binding site [ion binding]; other site
378806021266	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806021267	nucleotide binding region [chemical binding]; other site
378806021268	ATP-binding site [chemical binding]; other site
378806021269	Bacterial SH3 domain homologues; Region: SH3b; smart00287
378806021270	Putative catalytic domain of chitin deacetylase-like proteins from insects and similar proteins; Region: CE4_CDA_like; cd10919
378806021271	NodB motif; other site
378806021272	putative active site [active]
378806021273	putative catalytic site [active]
378806021274	putative Zn binding site [ion binding]; other site
378806021275	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806021276	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
378806021277	putative C-terminal domain interface [polypeptide binding]; other site
378806021278	putative GSH binding site (G-site) [chemical binding]; other site
378806021279	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806021280	putative dimer interface [polypeptide binding]; other site
378806021281	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
378806021282	dimer interface [polypeptide binding]; other site
378806021283	N-terminal domain interface [polypeptide binding]; other site
378806021284	putative substrate binding pocket (H-site) [chemical binding]; other site
378806021285	Pectinacetylesterase; Region: PAE; pfam03283
378806021286	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
378806021287	Cadmium resistance transporter; Region: Cad; pfam03596
378806021288	cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779
378806021289	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
378806021290	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
378806021291	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
378806021292	metal ion-dependent adhesion site (MIDAS); other site
378806021293	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
378806021294	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
378806021295	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
378806021296	ABC-ATPase subunit  interface; other site
378806021297	dimer interface [polypeptide binding]; other site
378806021298	putative PBP binding regions; other site
378806021299	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
378806021300	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
378806021301	intersubunit interface [polypeptide binding]; other site
378806021302	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
378806021303	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
378806021304	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
378806021305	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806021306	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806021307	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806021308	phosphopeptide binding site; other site
378806021309	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
378806021310	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
378806021311	Helix-hairpin-helix motif; Region: HHH; pfam00633
378806021312	Transcriptional regulators [Transcription]; Region: MarR; COG1846
378806021313	MarR family; Region: MarR; pfam01047
378806021314	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
378806021315	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
378806021316	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
378806021317	Zn binding site [ion binding]; other site
378806021318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806021319	TPR motif; other site
378806021320	binding surface
378806021321	Tetratricopeptide repeat; Region: TPR_16; pfam13432
378806021322	TPR repeat; Region: TPR_11; pfam13414
378806021323	Membrane transport protein; Region: Mem_trans; cl09117
378806021324	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
378806021325	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
378806021326	catalytic residues [active]
378806021327	FRG domain; Region: FRG; pfam08867
378806021328	RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001
378806021329	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806021330	DNA binding residues [nucleotide binding]
378806021331	Bacterial PH domain; Region: DUF304; cl01348
378806021332	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
378806021333	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
378806021334	MOSC domain; Region: MOSC; pfam03473
378806021335	Protein kinase domain; Region: Pkinase; pfam00069
378806021336	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021337	active site
378806021338	ATP binding site [chemical binding]; other site
378806021339	substrate binding site [chemical binding]; other site
378806021340	activation loop (A-loop); other site
378806021341	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806021342	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
378806021343	TAP-like protein; Region: Abhydrolase_4; pfam08386
378806021344	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806021345	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806021346	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806021347	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
378806021348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021349	dimer interface [polypeptide binding]; other site
378806021350	phosphorylation site [posttranslational modification]
378806021351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021352	ATP binding site [chemical binding]; other site
378806021353	Mg2+ binding site [ion binding]; other site
378806021354	G-X-G motif; other site
378806021355	Predicted transcriptional regulators [Transcription]; Region: COG1695
378806021356	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
378806021357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806021358	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
378806021359	RibD C-terminal domain; Region: RibD_C; cl17279
378806021360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806021361	S-adenosylmethionine binding site [chemical binding]; other site
378806021362	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
378806021363	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
378806021364	DNA binding residues [nucleotide binding]
378806021365	putative dimer interface [polypeptide binding]; other site
378806021366	putative metal binding residues [ion binding]; other site
378806021367	tellurite resistance protein terB; Region: terB; cd07176
378806021368	putative metal binding site [ion binding]; other site
378806021369	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806021370	Disintegrin; Region: Disintegrin; cl10507
378806021371	Disintegrin; Region: Disintegrin; cl10507
378806021372	Disintegrin; Region: Disintegrin; cl10507
378806021373	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
378806021374	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
378806021375	active site
378806021376	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
378806021377	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
378806021378	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
378806021379	Protein kinase domain; Region: Pkinase; pfam00069
378806021380	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021381	active site
378806021382	ATP binding site [chemical binding]; other site
378806021383	substrate binding site [chemical binding]; other site
378806021384	activation loop (A-loop); other site
378806021385	AAA ATPase domain; Region: AAA_16; pfam13191
378806021386	Predicted ATPase [General function prediction only]; Region: COG3899
378806021387	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806021388	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806021389	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806021390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021391	ATP binding site [chemical binding]; other site
378806021392	Mg2+ binding site [ion binding]; other site
378806021393	G-X-G motif; other site
378806021394	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806021395	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
378806021396	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806021397	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
378806021398	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806021399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021400	active site
378806021401	phosphorylation site [posttranslational modification]
378806021402	intermolecular recognition site; other site
378806021403	dimerization interface [polypeptide binding]; other site
378806021404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021405	dimer interface [polypeptide binding]; other site
378806021406	phosphorylation site [posttranslational modification]
378806021407	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
378806021408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021409	ATP binding site [chemical binding]; other site
378806021410	Mg2+ binding site [ion binding]; other site
378806021411	G-X-G motif; other site
378806021412	Response regulator receiver domain; Region: Response_reg; pfam00072
378806021413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021414	active site
378806021415	phosphorylation site [posttranslational modification]
378806021416	intermolecular recognition site; other site
378806021417	dimerization interface [polypeptide binding]; other site
378806021418	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806021419	PAS fold; Region: PAS_3; pfam08447
378806021420	putative active site [active]
378806021421	heme pocket [chemical binding]; other site
378806021422	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806021423	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806021424	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806021425	putative active site [active]
378806021426	PAS fold; Region: PAS_3; pfam08447
378806021427	heme pocket [chemical binding]; other site
378806021428	GAF domain; Region: GAF_2; pfam13185
378806021429	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806021430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021431	dimer interface [polypeptide binding]; other site
378806021432	phosphorylation site [posttranslational modification]
378806021433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021434	ATP binding site [chemical binding]; other site
378806021435	Mg2+ binding site [ion binding]; other site
378806021436	G-X-G motif; other site
378806021437	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
378806021438	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
378806021439	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
378806021440	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806021441	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806021442	active site
378806021443	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
378806021444	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
378806021445	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
378806021446	putative hydrophobic ligand binding site [chemical binding]; other site
378806021447	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
378806021448	dimerization interface [polypeptide binding]; other site
378806021449	putative DNA binding site [nucleotide binding]; other site
378806021450	putative Zn2+ binding site [ion binding]; other site
378806021451	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
378806021452	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
378806021453	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
378806021454	active site
378806021455	Zn binding site [ion binding]; other site
378806021456	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806021457	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
378806021458	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
378806021459	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806021460	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806021461	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806021462	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806021463	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806021464	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806021465	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
378806021466	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
378806021467	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806021468	ATP binding site [chemical binding]; other site
378806021469	putative Mg++ binding site [ion binding]; other site
378806021470	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806021471	nucleotide binding region [chemical binding]; other site
378806021472	ATP-binding site [chemical binding]; other site
378806021473	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806021474	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
378806021475	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
378806021476	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
378806021477	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806021478	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
378806021479	putative dimerization interface [polypeptide binding]; other site
378806021480	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
378806021481	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
378806021482	active site
378806021483	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
378806021484	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
378806021485	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
378806021486	DNA binding residues [nucleotide binding]
378806021487	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
378806021488	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
378806021489	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
378806021490	metal ion-dependent adhesion site (MIDAS); other site
378806021491	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
378806021492	putative active site [active]
378806021493	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
378806021494	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
378806021495	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
378806021496	Walker A/P-loop; other site
378806021497	ATP binding site [chemical binding]; other site
378806021498	Q-loop/lid; other site
378806021499	ABC transporter signature motif; other site
378806021500	Walker B; other site
378806021501	D-loop; other site
378806021502	H-loop/switch region; other site
378806021503	TOBE domain; Region: TOBE_2; pfam08402
378806021504	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
378806021505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806021506	dimer interface [polypeptide binding]; other site
378806021507	conserved gate region; other site
378806021508	putative PBP binding loops; other site
378806021509	ABC-ATPase subunit interface; other site
378806021510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
378806021511	dimer interface [polypeptide binding]; other site
378806021512	conserved gate region; other site
378806021513	putative PBP binding loops; other site
378806021514	ABC-ATPase subunit interface; other site
378806021515	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
378806021516	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
378806021517	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806021518	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
378806021519	putative active site [active]
378806021520	heme pocket [chemical binding]; other site
378806021521	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021522	dimer interface [polypeptide binding]; other site
378806021523	phosphorylation site [posttranslational modification]
378806021524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021525	ATP binding site [chemical binding]; other site
378806021526	Mg2+ binding site [ion binding]; other site
378806021527	G-X-G motif; other site
378806021528	DNA gyrase subunit A; Validated; Region: PRK05560
378806021529	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
378806021530	CAP-like domain; other site
378806021531	active site
378806021532	primary dimer interface [polypeptide binding]; other site
378806021533	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
378806021534	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
378806021535	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
378806021536	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
378806021537	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
378806021538	TPR repeat; Region: TPR_11; pfam13414
378806021539	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806021540	TPR motif; other site
378806021541	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
378806021542	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
378806021543	active site 2 [active]
378806021544	active site 1 [active]
378806021545	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806021546	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806021547	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
378806021548	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
378806021549	active site
378806021550	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
378806021551	catalytic core [active]
378806021552	Protein of unknown function (DUF952); Region: DUF952; pfam06108
378806021553	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
378806021554	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
378806021555	active site
378806021556	potential frameshift: common BLAST hit: gi|166368847|ref|YP_001661120.1| hyalin repeat-containing protein
378806021557	short chain dehydrogenase; Provisional; Region: PRK06139
378806021558	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
378806021559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806021560	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806021561	Walker A motif; other site
378806021562	ATP binding site [chemical binding]; other site
378806021563	Walker B motif; other site
378806021564	arginine finger; other site
378806021565	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806021566	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
378806021567	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
378806021568	active site residue [active]
378806021569	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
378806021570	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
378806021571	Two component regulator propeller; Region: Reg_prop; pfam07494
378806021572	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
378806021573	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
378806021574	Histidine kinase; Region: HisKA_3; pfam07730
378806021575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021576	ATP binding site [chemical binding]; other site
378806021577	Mg2+ binding site [ion binding]; other site
378806021578	G-X-G motif; other site
378806021579	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806021580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021581	active site
378806021582	phosphorylation site [posttranslational modification]
378806021583	intermolecular recognition site; other site
378806021584	dimerization interface [polypeptide binding]; other site
378806021585	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806021586	DNA binding residues [nucleotide binding]
378806021587	dimerization interface [polypeptide binding]; other site
378806021588	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806021589	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806021590	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806021591	calcium binding site 2 [ion binding]; other site
378806021592	active site
378806021593	catalytic triad [active]
378806021594	calcium binding site 1 [ion binding]; other site
378806021595	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806021596	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
378806021597	NAD(P) binding site [chemical binding]; other site
378806021598	active site
378806021599	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
378806021600	DDE superfamily endonuclease; Region: DDE_3; pfam13358
378806021601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021602	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806021603	G-X-G motif; other site
378806021604	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
378806021605	homotrimer interaction site [polypeptide binding]; other site
378806021606	putative active site [active]
378806021607	MarR family; Region: MarR_2; cl17246
378806021608	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
378806021609	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806021610	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806021611	active site
378806021612	catalytic tetrad [active]
378806021613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
378806021614	dimerization interface [polypeptide binding]; other site
378806021615	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806021616	Kelch domain; Region: Kelch; smart00612
378806021617	Kelch motif; Region: Kelch_6; pfam13964
378806021618	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806021619	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806021620	TPR motif; other site
378806021621	binding surface
378806021622	TPR repeat; Region: TPR_11; pfam13414
378806021623	TPR repeat; Region: TPR_11; pfam13414
378806021624	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806021625	binding surface
378806021626	TPR motif; other site
378806021627	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
378806021628	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
378806021629	ligand binding site [chemical binding]; other site
378806021630	active site
378806021631	UGI interface [polypeptide binding]; other site
378806021632	catalytic site [active]
378806021633	Type II/IV secretion system protein; Region: T2SE; pfam00437
378806021634	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
378806021635	ATP binding site [chemical binding]; other site
378806021636	Walker A motif; other site
378806021637	hexamer interface [polypeptide binding]; other site
378806021638	Walker B motif; other site
378806021639	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806021640	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021641	active site
378806021642	ATP binding site [chemical binding]; other site
378806021643	substrate binding site [chemical binding]; other site
378806021644	activation loop (A-loop); other site
378806021645	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
378806021646	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
378806021647	FAD binding pocket [chemical binding]; other site
378806021648	conserved FAD binding motif [chemical binding]; other site
378806021649	phosphate binding motif [ion binding]; other site
378806021650	beta-alpha-beta structure motif; other site
378806021651	NAD binding pocket [chemical binding]; other site
378806021652	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806021653	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806021654	structural tetrad; other site
378806021655	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
378806021656	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806021657	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
378806021658	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
378806021659	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
378806021660	putative ligand binding site [chemical binding]; other site
378806021661	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806021662	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021663	active site
378806021664	ATP binding site [chemical binding]; other site
378806021665	substrate binding site [chemical binding]; other site
378806021666	activation loop (A-loop); other site
378806021667	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
378806021668	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806021669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021670	intermolecular recognition site; other site
378806021671	active site
378806021672	dimerization interface [polypeptide binding]; other site
378806021673	chaperone protein DnaJ; Provisional; Region: PRK10767
378806021674	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806021675	HSP70 interaction site [polypeptide binding]; other site
378806021676	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
378806021677	substrate binding site [polypeptide binding]; other site
378806021678	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
378806021679	Zn binding sites [ion binding]; other site
378806021680	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
378806021681	dimer interface [polypeptide binding]; other site
378806021682	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
378806021683	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
378806021684	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806021685	Walker A/P-loop; other site
378806021686	ATP binding site [chemical binding]; other site
378806021687	Q-loop/lid; other site
378806021688	ABC transporter signature motif; other site
378806021689	Walker B; other site
378806021690	D-loop; other site
378806021691	H-loop/switch region; other site
378806021692	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806021693	HAMP domain; Region: HAMP; pfam00672
378806021694	dimerization interface [polypeptide binding]; other site
378806021695	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021696	dimer interface [polypeptide binding]; other site
378806021697	phosphorylation site [posttranslational modification]
378806021698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021699	ATP binding site [chemical binding]; other site
378806021700	Mg2+ binding site [ion binding]; other site
378806021701	G-X-G motif; other site
378806021702	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
378806021703	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806021704	motif II; other site
378806021705	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
378806021706	Zn binding site [ion binding]; other site
378806021707	ATP-dependent helicase HepA; Validated; Region: PRK04914
378806021708	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806021709	ATP binding site [chemical binding]; other site
378806021710	putative Mg++ binding site [ion binding]; other site
378806021711	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806021712	nucleotide binding region [chemical binding]; other site
378806021713	ATP-binding site [chemical binding]; other site
378806021714	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806021715	GAF domain; Region: GAF; pfam01590
378806021716	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806021717	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
378806021718	dimer interface [polypeptide binding]; other site
378806021719	phosphorylation site [posttranslational modification]
378806021720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021721	ATP binding site [chemical binding]; other site
378806021722	Mg2+ binding site [ion binding]; other site
378806021723	G-X-G motif; other site
378806021724	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
378806021725	heme-binding residues [chemical binding]; other site
378806021726	Uncharacterized conserved protein [Function unknown]; Region: COG3287
378806021727	FIST N domain; Region: FIST; pfam08495
378806021728	FIST C domain; Region: FIST_C; pfam10442
378806021729	PAS fold; Region: PAS_4; pfam08448
378806021730	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806021731	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021732	dimer interface [polypeptide binding]; other site
378806021733	phosphorylation site [posttranslational modification]
378806021734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021735	ATP binding site [chemical binding]; other site
378806021736	Mg2+ binding site [ion binding]; other site
378806021737	G-X-G motif; other site
378806021738	Response regulator receiver domain; Region: Response_reg; pfam00072
378806021739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021740	active site
378806021741	phosphorylation site [posttranslational modification]
378806021742	intermolecular recognition site; other site
378806021743	dimerization interface [polypeptide binding]; other site
378806021744	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806021745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021746	active site
378806021747	phosphorylation site [posttranslational modification]
378806021748	intermolecular recognition site; other site
378806021749	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806021750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021751	active site
378806021752	phosphorylation site [posttranslational modification]
378806021753	intermolecular recognition site; other site
378806021754	dimerization interface [polypeptide binding]; other site
378806021755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021756	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806021757	active site
378806021758	phosphorylation site [posttranslational modification]
378806021759	intermolecular recognition site; other site
378806021760	dimerization interface [polypeptide binding]; other site
378806021761	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
378806021762	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
378806021763	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
378806021764	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
378806021765	catalytic residue [active]
378806021766	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
378806021767	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
378806021768	putative DNA binding site [nucleotide binding]; other site
378806021769	putative Zn2+ binding site [ion binding]; other site
378806021770	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806021771	S-adenosylmethionine binding site [chemical binding]; other site
378806021772	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806021773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021774	active site
378806021775	phosphorylation site [posttranslational modification]
378806021776	intermolecular recognition site; other site
378806021777	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806021778	DNA binding residues [nucleotide binding]
378806021779	dimerization interface [polypeptide binding]; other site
378806021780	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
378806021781	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
378806021782	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
378806021783	PAS fold; Region: PAS_4; pfam08448
378806021784	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806021785	putative active site [active]
378806021786	heme pocket [chemical binding]; other site
378806021787	PAS fold; Region: PAS; pfam00989
378806021788	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806021789	putative active site [active]
378806021790	heme pocket [chemical binding]; other site
378806021791	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021792	dimer interface [polypeptide binding]; other site
378806021793	phosphorylation site [posttranslational modification]
378806021794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021795	ATP binding site [chemical binding]; other site
378806021796	Mg2+ binding site [ion binding]; other site
378806021797	G-X-G motif; other site
378806021798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021799	active site
378806021800	phosphorylation site [posttranslational modification]
378806021801	intermolecular recognition site; other site
378806021802	CheB methylesterase; Region: CheB_methylest; pfam01339
378806021803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021804	Response regulator receiver domain; Region: Response_reg; pfam00072
378806021805	active site
378806021806	phosphorylation site [posttranslational modification]
378806021807	intermolecular recognition site; other site
378806021808	dimerization interface [polypeptide binding]; other site
378806021809	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
378806021810	ABC1 family; Region: ABC1; cl17513
378806021811	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806021812	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021813	active site
378806021814	ATP binding site [chemical binding]; other site
378806021815	substrate binding site [chemical binding]; other site
378806021816	activation loop (A-loop); other site
378806021817	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806021818	Tetratricopeptide repeat; Region: TPR_1; pfam00515
378806021819	Response regulator receiver domain; Region: Response_reg; pfam00072
378806021820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021821	active site
378806021822	phosphorylation site [posttranslational modification]
378806021823	intermolecular recognition site; other site
378806021824	dimerization interface [polypeptide binding]; other site
378806021825	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806021826	PAS domain; Region: PAS_9; pfam13426
378806021827	putative active site [active]
378806021828	heme pocket [chemical binding]; other site
378806021829	GAF domain; Region: GAF_2; pfam13185
378806021830	GAF domain; Region: GAF; cl17456
378806021831	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806021832	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021833	dimer interface [polypeptide binding]; other site
378806021834	phosphorylation site [posttranslational modification]
378806021835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021836	ATP binding site [chemical binding]; other site
378806021837	Mg2+ binding site [ion binding]; other site
378806021838	G-X-G motif; other site
378806021839	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806021840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021841	active site
378806021842	phosphorylation site [posttranslational modification]
378806021843	intermolecular recognition site; other site
378806021844	dimerization interface [polypeptide binding]; other site
378806021845	Response regulator receiver domain; Region: Response_reg; pfam00072
378806021846	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021847	active site
378806021848	phosphorylation site [posttranslational modification]
378806021849	intermolecular recognition site; other site
378806021850	dimerization interface [polypeptide binding]; other site
378806021851	CheB methylesterase; Region: CheB_methylest; pfam01339
378806021852	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
378806021853	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806021854	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021855	dimerization interface [polypeptide binding]; other site
378806021856	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806021857	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021858	dimerization interface [polypeptide binding]; other site
378806021859	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021860	dimerization interface [polypeptide binding]; other site
378806021861	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021862	dimerization interface [polypeptide binding]; other site
378806021863	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021864	dimerization interface [polypeptide binding]; other site
378806021865	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
378806021866	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021867	dimerization interface [polypeptide binding]; other site
378806021868	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021869	dimerization interface [polypeptide binding]; other site
378806021870	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021871	dimerization interface [polypeptide binding]; other site
378806021872	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021873	dimerization interface [polypeptide binding]; other site
378806021874	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021875	dimerization interface [polypeptide binding]; other site
378806021876	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806021877	dimerization interface [polypeptide binding]; other site
378806021878	GAF domain; Region: GAF_2; pfam13185
378806021879	GAF domain; Region: GAF; pfam01590
378806021880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021881	dimer interface [polypeptide binding]; other site
378806021882	phosphorylation site [posttranslational modification]
378806021883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021884	ATP binding site [chemical binding]; other site
378806021885	Mg2+ binding site [ion binding]; other site
378806021886	G-X-G motif; other site
378806021887	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806021888	Response regulator receiver domain; Region: Response_reg; pfam00072
378806021889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
378806021890	active site
378806021891	phosphorylation site [posttranslational modification]
378806021892	intermolecular recognition site; other site
378806021893	dimerization interface [polypeptide binding]; other site
378806021894	Response regulator receiver domain; Region: Response_reg; pfam00072
378806021895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806021896	active site
378806021897	phosphorylation site [posttranslational modification]
378806021898	intermolecular recognition site; other site
378806021899	dimerization interface [polypeptide binding]; other site
378806021900	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806021901	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806021902	DNA-binding site [nucleotide binding]; DNA binding site
378806021903	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806021904	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
378806021905	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
378806021906	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
378806021907	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
378806021908	Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357
378806021909	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
378806021910	DNA-binding site [nucleotide binding]; DNA binding site
378806021911	RNA-binding motif; other site
378806021912	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
378806021913	anti sigma factor interaction site; other site
378806021914	regulatory phosphorylation site [posttranslational modification]; other site
378806021915	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
378806021916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021917	ATP binding site [chemical binding]; other site
378806021918	Mg2+ binding site [ion binding]; other site
378806021919	G-X-G motif; other site
378806021920	conserved repeat domain; Region: B_ant_repeat; TIGR01451
378806021921	Domain of unknown function DUF11; Region: DUF11; pfam01345
378806021922	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806021923	Predicted transcriptional regulator [Transcription]; Region: COG1959
378806021924	Transcriptional regulator; Region: Rrf2; pfam02082
378806021925	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
378806021926	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
378806021927	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806021928	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021929	active site
378806021930	ATP binding site [chemical binding]; other site
378806021931	substrate binding site [chemical binding]; other site
378806021932	activation loop (A-loop); other site
378806021933	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806021934	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806021935	active site
378806021936	ATP binding site [chemical binding]; other site
378806021937	substrate binding site [chemical binding]; other site
378806021938	activation loop (A-loop); other site
378806021939	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806021940	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806021941	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806021942	PAS domain; Region: PAS_9; pfam13426
378806021943	putative active site [active]
378806021944	heme pocket [chemical binding]; other site
378806021945	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806021946	PAS fold; Region: PAS_3; pfam08447
378806021947	putative active site [active]
378806021948	heme pocket [chemical binding]; other site
378806021949	PAS fold; Region: PAS_4; pfam08448
378806021950	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806021951	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806021952	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806021953	dimer interface [polypeptide binding]; other site
378806021954	phosphorylation site [posttranslational modification]
378806021955	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
378806021956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806021957	ATP binding site [chemical binding]; other site
378806021958	Mg2+ binding site [ion binding]; other site
378806021959	G-X-G motif; other site
378806021960	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
378806021961	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
378806021962	dimerization interface [polypeptide binding]; other site
378806021963	ATP binding site [chemical binding]; other site
378806021964	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
378806021965	dimerization interface [polypeptide binding]; other site
378806021966	ATP binding site [chemical binding]; other site
378806021967	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
378806021968	putative active site [active]
378806021969	catalytic triad [active]
378806021970	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
378806021971	active site
378806021972	Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056
378806021973	ribonuclease Z; Region: RNase_Z; TIGR02651
378806021974	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
378806021975	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
378806021976	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
378806021977	active site
378806021978	PEGA domain; Region: PEGA; pfam08308
378806021979	Type II/IV secretion system protein; Region: T2SE; pfam00437
378806021980	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806021981	Walker A motif; other site
378806021982	ATP binding site [chemical binding]; other site
378806021983	Walker B motif; other site
378806021984	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
378806021985	cleavage site
378806021986	active site
378806021987	substrate binding sites [chemical binding]; other site
378806021988	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
378806021989	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
378806021990	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
378806021991	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
378806021992	active site
378806021993	catalytic triad [active]
378806021994	oxyanion hole [active]
378806021995	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
378806021996	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
378806021997	catalytic triad [active]
378806021998	putative active site [active]
378806021999	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
378806022000	catalytic core [active]
378806022001	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806022002	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806022003	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
378806022004	amphipathic channel; other site
378806022005	Asn-Pro-Ala signature motifs; other site
378806022006	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
378806022007	active site
378806022008	Double zinc ribbon; Region: DZR; pfam12773
378806022009	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
378806022010	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806022011	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
378806022012	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
378806022013	GON domain; Region: GON; pfam08685
378806022014	GON domain; Region: GON; pfam08685
378806022015	Protein kinase domain; Region: Pkinase; pfam00069
378806022016	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806022017	active site
378806022018	substrate binding site [chemical binding]; other site
378806022019	activation loop (A-loop); other site
378806022020	AAA ATPase domain; Region: AAA_16; pfam13191
378806022021	Predicted ATPase [General function prediction only]; Region: COG3899
378806022022	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806022023	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806022024	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806022025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022026	ATP binding site [chemical binding]; other site
378806022027	Mg2+ binding site [ion binding]; other site
378806022028	G-X-G motif; other site
378806022029	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806022030	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806022031	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806022032	TPR repeat; Region: TPR_11; pfam13414
378806022033	binding surface
378806022034	TPR motif; other site
378806022035	The Bacteroides thetaiotaomicron protein represented by pdb structure 3CO4 is an uncharacterized bacterial member of the family 18 glycosyl hydrolases with homologs found in Flavobacterium, Stigmatella, and Pseudomonas; Region: GH18_3CO4_chitinase; cd06545
378806022036	Glyco_18 domain; Region: Glyco_18; smart00636
378806022037	putative active site [active]
378806022038	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806022039	sugar binding site [chemical binding]; other site
378806022040	Alginate lyase; Region: Alginate_lyase2; pfam08787
378806022041	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806022042	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806022043	DNA-binding site [nucleotide binding]; DNA binding site
378806022044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806022045	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806022046	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
378806022047	FeS/SAM binding site; other site
378806022048	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
378806022049	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806022050	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
378806022051	DNA binding residues [nucleotide binding]
378806022052	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806022053	AAA domain; Region: AAA_21; pfam13304
378806022054	Walker A/P-loop; other site
378806022055	ATP binding site [chemical binding]; other site
378806022056	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022057	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022058	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022059	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022060	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022061	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022062	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022063	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022064	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022065	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022066	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022067	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022068	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022069	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022070	active site
378806022071	ATP binding site [chemical binding]; other site
378806022072	substrate binding site [chemical binding]; other site
378806022073	activation loop (A-loop); other site
378806022074	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
378806022075	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806022076	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806022077	phosphopeptide binding site; other site
378806022078	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
378806022079	I-site; other site
378806022080	active site
378806022081	metal binding site [ion binding]; metal-binding site
378806022082	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806022083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806022084	Walker A motif; other site
378806022085	ATP binding site [chemical binding]; other site
378806022086	Walker B motif; other site
378806022087	arginine finger; other site
378806022088	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806022089	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
378806022090	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806022091	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022092	active site
378806022093	ATP binding site [chemical binding]; other site
378806022094	substrate binding site [chemical binding]; other site
378806022095	activation loop (A-loop); other site
378806022096	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
378806022097	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
378806022098	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806022099	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806022100	Walker A motif; other site
378806022101	ATP binding site [chemical binding]; other site
378806022102	Walker B motif; other site
378806022103	arginine finger; other site
378806022104	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806022105	putative catalytic site [active]
378806022106	putative metal binding site [ion binding]; other site
378806022107	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806022108	putative catalytic site [active]
378806022109	putative phosphate binding site [ion binding]; other site
378806022110	putative phosphate binding site [ion binding]; other site
378806022111	putative metal binding site [ion binding]; other site
378806022112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806022113	PAS domain; Region: PAS_9; pfam13426
378806022114	putative active site [active]
378806022115	heme pocket [chemical binding]; other site
378806022116	PAS domain; Region: PAS_9; pfam13426
378806022117	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806022118	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022119	dimer interface [polypeptide binding]; other site
378806022120	phosphorylation site [posttranslational modification]
378806022121	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022122	ATP binding site [chemical binding]; other site
378806022123	Mg2+ binding site [ion binding]; other site
378806022124	G-X-G motif; other site
378806022125	TspO/MBR family; Region: TspO_MBR; pfam03073
378806022126	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
378806022127	dinuclear metal binding motif [ion binding]; other site
378806022128	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
378806022129	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
378806022130	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806022131	P-loop; other site
378806022132	Magnesium ion binding site [ion binding]; other site
378806022133	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806022134	Magnesium ion binding site [ion binding]; other site
378806022135	Rubredoxin [Energy production and conversion]; Region: COG1773
378806022136	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
378806022137	iron binding site [ion binding]; other site
378806022138	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
378806022139	Uncharacterized conserved protein [Function unknown]; Region: COG4748
378806022140	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
378806022141	DDE superfamily endonuclease; Region: DDE_5; cl17874
378806022142	Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693
378806022143	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
378806022144	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
378806022145	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
378806022146	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
378806022147	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
378806022148	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
378806022149	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
378806022150	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
378806022151	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806022152	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806022153	Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289
378806022154	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
378806022155	DNA-binding site [nucleotide binding]; DNA binding site
378806022156	RNA-binding motif; other site
378806022157	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
378806022158	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
378806022159	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022160	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022161	active site
378806022162	ATP binding site [chemical binding]; other site
378806022163	substrate binding site [chemical binding]; other site
378806022164	activation loop (A-loop); other site
378806022165	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806022166	AAA ATPase domain; Region: AAA_16; pfam13191
378806022167	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806022168	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
378806022169	Subtilase family; Region: Peptidase_S8; pfam00082
378806022170	catalytic residues [active]
378806022171	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
378806022172	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
378806022173	Predicted transcriptional regulators [Transcription]; Region: COG1733
378806022174	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
378806022175	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806022176	Matrixin; Region: Peptidase_M10; pfam00413
378806022177	active site
378806022178	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
378806022179	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
378806022180	putative active site [active]
378806022181	putative NTP binding site [chemical binding]; other site
378806022182	putative nucleic acid binding site [nucleotide binding]; other site
378806022183	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806022184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806022185	S-adenosylmethionine binding site [chemical binding]; other site
378806022186	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
378806022187	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
378806022188	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806022189	putative di-iron ligands [ion binding]; other site
378806022190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
378806022191	metabolite-proton symporter; Region: 2A0106; TIGR00883
378806022192	putative substrate translocation pore; other site
378806022193	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
378806022194	active sites [active]
378806022195	tetramer interface [polypeptide binding]; other site
378806022196	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806022197	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
378806022198	HSP70 interaction site [polypeptide binding]; other site
378806022199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
378806022200	SnoaL-like domain; Region: SnoaL_2; pfam12680
378806022201	Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226
378806022202	putative active site [active]
378806022203	Zn binding site [ion binding]; other site
378806022204	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806022205	Kelch domain; Region: Kelch; smart00612
378806022206	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806022207	Kelch domain; Region: Kelch; smart00612
378806022208	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806022209	Kelch motif; Region: Kelch_6; pfam13964
378806022210	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806022211	Kelch domain; Region: Kelch; smart00612
378806022212	REJ domain; Region: REJ; pfam02010
378806022213	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
378806022214	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806022215	Kelch domain; Region: Kelch; smart00612
378806022216	Kelch motif; Region: Kelch_1; pfam01344
378806022217	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806022218	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806022219	Kelch motif; Region: Kelch_6; pfam13964
378806022220	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806022221	Kelch domain; Region: Kelch; smart00612
378806022222	Kelch motif; Region: Kelch_1; pfam01344
378806022223	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
378806022224	Kelch domain; Region: Kelch; smart00612
378806022225	CHAT domain; Region: CHAT; pfam12770
378806022226	RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1
378806022227	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806022228	Peptidase family M23; Region: Peptidase_M23; pfam01551
378806022229	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806022230	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
378806022231	dimer interface [polypeptide binding]; other site
378806022232	N-terminal domain interface [polypeptide binding]; other site
378806022233	putative substrate binding pocket (H-site) [chemical binding]; other site
378806022234	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
378806022235	PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112
378806022236	PAN domain; Region: PAN_4; pfam14295
378806022237	putative binding site; other site
378806022238	malonyl-CoA synthase; Validated; Region: PRK07514
378806022239	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
378806022240	acyl-activating enzyme (AAE) consensus motif; other site
378806022241	active site
378806022242	AMP binding site [chemical binding]; other site
378806022243	CoA binding site [chemical binding]; other site
378806022244	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
378806022245	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806022246	DNA binding residues [nucleotide binding]
378806022247	dimerization interface [polypeptide binding]; other site
378806022248	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022249	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022250	active site
378806022251	ATP binding site [chemical binding]; other site
378806022252	substrate binding site [chemical binding]; other site
378806022253	activation loop (A-loop); other site
378806022254	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806022255	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806022256	TPR motif; other site
378806022257	binding surface
378806022258	Tetratricopeptide repeat; Region: TPR_12; pfam13424
378806022259	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806022260	phosphopeptide binding site; other site
378806022261	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806022262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806022263	Walker A motif; other site
378806022264	ATP binding site [chemical binding]; other site
378806022265	Walker B motif; other site
378806022266	arginine finger; other site
378806022267	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
378806022268	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
378806022269	putative active site [active]
378806022270	Isochorismatase family; Region: Isochorismatase; pfam00857
378806022271	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
378806022272	catalytic triad [active]
378806022273	dimer interface [polypeptide binding]; other site
378806022274	conserved cis-peptide bond; other site
378806022275	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
378806022276	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
378806022277	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806022278	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806022279	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
378806022280	Beta-lactamase; Region: Beta-lactamase; pfam00144
378806022281	Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317
378806022282	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
378806022283	active site
378806022284	Ca binding site [ion binding]; other site
378806022285	catalytic site [active]
378806022286	Aamy_C domain; Region: Aamy_C; smart00632
378806022287	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956
378806022288	starch binding site [chemical binding]; other site
378806022289	Glucan 1,4-alpha-maltotetraohydrolase (alpha-MTH), C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Alpha-MTH, also known as maltotetraose-forming exo-amylase or G4-amylase, is an exo-amylase found in bacteria that degrades starch from...; Region: CBM20_alpha_MTH; cd05810
378806022290	starch-binding site 2 [chemical binding]; other site
378806022291	starch-binding site 1 [chemical binding]; other site
378806022292	Pirin-related protein [General function prediction only]; Region: COG1741
378806022293	Pirin; Region: Pirin; pfam02678
378806022294	LysR family transcriptional regulator; Provisional; Region: PRK14997
378806022295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806022296	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
378806022297	putative effector binding pocket; other site
378806022298	dimerization interface [polypeptide binding]; other site
378806022299	Uncharacterized conserved protein [Function unknown]; Region: COG2353
378806022300	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022301	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022302	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022303	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022304	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022305	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022306	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022307	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022308	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022309	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022310	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806022311	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022312	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022313	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806022314	GAF domain; Region: GAF; cl17456
378806022315	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806022316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806022317	Walker A motif; other site
378806022318	ATP binding site [chemical binding]; other site
378806022319	Walker B motif; other site
378806022320	arginine finger; other site
378806022321	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806022322	Pirin-related protein [General function prediction only]; Region: COG1741
378806022323	Pirin; Region: Pirin; pfam02678
378806022324	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
378806022325	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806022326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806022327	non-specific DNA binding site [nucleotide binding]; other site
378806022328	salt bridge; other site
378806022329	sequence-specific DNA binding site [nucleotide binding]; other site
378806022330	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806022331	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
378806022332	putative di-iron ligands [ion binding]; other site
378806022333	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
378806022334	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
378806022335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806022336	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
378806022337	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
378806022338	putative C-terminal domain interface [polypeptide binding]; other site
378806022339	putative GSH binding site (G-site) [chemical binding]; other site
378806022340	putative dimer interface [polypeptide binding]; other site
378806022341	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
378806022342	dimer interface [polypeptide binding]; other site
378806022343	N-terminal domain interface [polypeptide binding]; other site
378806022344	putative substrate binding pocket (H-site) [chemical binding]; other site
378806022345	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
378806022346	PLD-like domain; Region: PLDc_2; pfam13091
378806022347	putative active site [active]
378806022348	catalytic site [active]
378806022349	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806022350	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
378806022351	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
378806022352	NAD(P) binding site [chemical binding]; other site
378806022353	catalytic residues [active]
378806022354	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
378806022355	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
378806022356	NAD(P) binding site [chemical binding]; other site
378806022357	catalytic residues [active]
378806022358	B3/4 domain; Region: B3_4; pfam03483
378806022359	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
378806022360	AAA domain; Region: AAA_33; pfam13671
378806022361	ATP-binding site [chemical binding]; other site
378806022362	Gluconate-6-phosphate binding site [chemical binding]; other site
378806022363	PAS domain S-box; Region: sensory_box; TIGR00229
378806022364	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806022365	putative active site [active]
378806022366	heme pocket [chemical binding]; other site
378806022367	GAF domain; Region: GAF; cl17456
378806022368	PAS domain; Region: PAS_8; pfam13188
378806022369	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806022370	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022371	dimer interface [polypeptide binding]; other site
378806022372	phosphorylation site [posttranslational modification]
378806022373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022374	ATP binding site [chemical binding]; other site
378806022375	Mg2+ binding site [ion binding]; other site
378806022376	G-X-G motif; other site
378806022377	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806022378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022379	active site
378806022380	phosphorylation site [posttranslational modification]
378806022381	intermolecular recognition site; other site
378806022382	dimerization interface [polypeptide binding]; other site
378806022383	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806022384	GAF domain; Region: GAF; pfam01590
378806022385	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806022386	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022387	dimer interface [polypeptide binding]; other site
378806022388	phosphorylation site [posttranslational modification]
378806022389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022390	ATP binding site [chemical binding]; other site
378806022391	Mg2+ binding site [ion binding]; other site
378806022392	G-X-G motif; other site
378806022393	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
378806022394	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
378806022395	active site
378806022396	metal binding site [ion binding]; metal-binding site
378806022397	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
378806022398	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
378806022399	active site
378806022400	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
378806022401	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
378806022402	NAD(P) binding site [chemical binding]; other site
378806022403	catalytic residues [active]
378806022404	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
378806022405	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
378806022406	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
378806022407	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
378806022408	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
378806022409	Mechanosensitive ion channel; Region: MS_channel; pfam00924
378806022410	CHASE domain; Region: CHASE; pfam03924
378806022411	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
378806022412	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806022413	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806022414	putative active site [active]
378806022415	heme pocket [chemical binding]; other site
378806022416	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022417	dimer interface [polypeptide binding]; other site
378806022418	phosphorylation site [posttranslational modification]
378806022419	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022420	ATP binding site [chemical binding]; other site
378806022421	Mg2+ binding site [ion binding]; other site
378806022422	G-X-G motif; other site
378806022423	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022424	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022425	active site
378806022426	ATP binding site [chemical binding]; other site
378806022427	substrate binding site [chemical binding]; other site
378806022428	activation loop (A-loop); other site
378806022429	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
378806022430	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
378806022431	translation initiation factor IF-3; Region: infC; TIGR00168
378806022432	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
378806022433	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
378806022434	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
378806022435	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
378806022436	NHL repeat; Region: NHL; pfam01436
378806022437	Uncharacterized conserved protein [Function unknown]; Region: COG3391
378806022438	Uncharacterized conserved protein [Function unknown]; Region: COG3391
378806022439	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
378806022440	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
378806022441	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
378806022442	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
378806022443	Stage II sporulation protein; Region: SpoIID; pfam08486
378806022444	MG2 domain; Region: A2M_N; pfam01835
378806022445	Alpha-2-macroglobulin family; Region: A2M; pfam00207
378806022446	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
378806022447	Protein of unknown function (DUF1175); Region: DUF1175; cl14898
378806022448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
378806022449	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
378806022450	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
378806022451	dimerization interface [polypeptide binding]; other site
378806022452	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806022453	PAS domain; Region: PAS_9; pfam13426
378806022454	putative active site [active]
378806022455	heme pocket [chemical binding]; other site
378806022456	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806022457	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806022458	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806022459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022460	dimer interface [polypeptide binding]; other site
378806022461	phosphorylation site [posttranslational modification]
378806022462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022463	ATP binding site [chemical binding]; other site
378806022464	Mg2+ binding site [ion binding]; other site
378806022465	G-X-G motif; other site
378806022466	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
378806022467	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
378806022468	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
378806022469	active site
378806022470	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
378806022471	Putative esterase; Region: Esterase; pfam00756
378806022472	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806022473	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
378806022474	Predicted ATPase [General function prediction only]; Region: COG4637
378806022475	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806022476	Walker A/P-loop; other site
378806022477	ATP binding site [chemical binding]; other site
378806022478	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806022479	ABC transporter signature motif; other site
378806022480	Walker B; other site
378806022481	D-loop; other site
378806022482	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
378806022483	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
378806022484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806022485	Walker A/P-loop; other site
378806022486	ATP binding site [chemical binding]; other site
378806022487	Q-loop/lid; other site
378806022488	ABC transporter signature motif; other site
378806022489	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806022490	ABC transporter; Region: ABC_tran_2; pfam12848
378806022491	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
378806022492	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
378806022493	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806022494	Walker A/P-loop; other site
378806022495	ATP binding site [chemical binding]; other site
378806022496	Q-loop/lid; other site
378806022497	ABC transporter signature motif; other site
378806022498	Walker B; other site
378806022499	D-loop; other site
378806022500	H-loop/switch region; other site
378806022501	ABC-2 type transporter; Region: ABC2_membrane; cl17235
378806022502	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
378806022503	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806022504	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022505	active site
378806022506	ATP binding site [chemical binding]; other site
378806022507	substrate binding site [chemical binding]; other site
378806022508	activation loop (A-loop); other site
378806022509	PEGA domain; Region: PEGA; pfam08308
378806022510	PAS domain; Region: PAS_9; pfam13426
378806022511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806022512	putative active site [active]
378806022513	heme pocket [chemical binding]; other site
378806022514	PAS fold; Region: PAS_4; pfam08448
378806022515	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806022516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022517	ATP binding site [chemical binding]; other site
378806022518	Mg2+ binding site [ion binding]; other site
378806022519	G-X-G motif; other site
378806022520	Response regulator receiver domain; Region: Response_reg; pfam00072
378806022521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022522	active site
378806022523	phosphorylation site [posttranslational modification]
378806022524	intermolecular recognition site; other site
378806022525	dimerization interface [polypeptide binding]; other site
378806022526	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
378806022527	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
378806022528	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
378806022529	catalytic site [active]
378806022530	active site
378806022531	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
378806022532	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806022533	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
378806022534	Walker A motif; other site
378806022535	ATP binding site [chemical binding]; other site
378806022536	Walker B motif; other site
378806022537	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
378806022538	YhhN-like protein; Region: YhhN; cl01505
378806022539	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
378806022540	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806022541	active site
378806022542	ATP binding site [chemical binding]; other site
378806022543	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806022544	substrate binding site [chemical binding]; other site
378806022545	activation loop (A-loop); other site
378806022546	AAA ATPase domain; Region: AAA_16; pfam13191
378806022547	Double zinc ribbon; Region: DZR; pfam12773
378806022548	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022549	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022550	active site
378806022551	ATP binding site [chemical binding]; other site
378806022552	substrate binding site [chemical binding]; other site
378806022553	activation loop (A-loop); other site
378806022554	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806022555	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806022556	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
378806022557	DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056
378806022558	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
378806022559	active site
378806022560	putative interdomain interaction site [polypeptide binding]; other site
378806022561	putative metal-binding site [ion binding]; other site
378806022562	putative nucleotide binding site [chemical binding]; other site
378806022563	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
378806022564	domain I; other site
378806022565	phosphate binding site [ion binding]; other site
378806022566	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
378806022567	domain II; other site
378806022568	domain III; other site
378806022569	nucleotide binding site [chemical binding]; other site
378806022570	DNA binding groove [nucleotide binding]
378806022571	catalytic site [active]
378806022572	domain IV; other site
378806022573	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
378806022574	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806022575	ATP binding site [chemical binding]; other site
378806022576	putative Mg++ binding site [ion binding]; other site
378806022577	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806022578	nucleotide binding region [chemical binding]; other site
378806022579	ATP-binding site [chemical binding]; other site
378806022580	HRDC domain; Region: HRDC; pfam00570
378806022581	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
378806022582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806022583	NAD(P) binding site [chemical binding]; other site
378806022584	active site
378806022585	TLC ATP/ADP transporter; Region: TLC; cl03940
378806022586	aspartate aminotransferase; Provisional; Region: PRK05764
378806022587	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
378806022588	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806022589	homodimer interface [polypeptide binding]; other site
378806022590	catalytic residue [active]
378806022591	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
378806022592	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
378806022593	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
378806022594	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022595	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022596	active site
378806022597	ATP binding site [chemical binding]; other site
378806022598	substrate binding site [chemical binding]; other site
378806022599	activation loop (A-loop); other site
378806022600	AAA ATPase domain; Region: AAA_16; pfam13191
378806022601	Uncharacterized conserved protein [Function unknown]; Region: COG1262
378806022602	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
378806022603	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806022604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022605	active site
378806022606	phosphorylation site [posttranslational modification]
378806022607	intermolecular recognition site; other site
378806022608	dimerization interface [polypeptide binding]; other site
378806022609	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
378806022610	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
378806022611	nucleotide binding site/active site [active]
378806022612	HIT family signature motif; other site
378806022613	catalytic residue [active]
378806022614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806022615	S-adenosylmethionine binding site [chemical binding]; other site
378806022616	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
378806022617	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
378806022618	NAD(P) binding site [chemical binding]; other site
378806022619	active site
378806022620	short chain dehydrogenase; Provisional; Region: PRK07454
378806022621	classical (c) SDRs; Region: SDR_c; cd05233
378806022622	NAD(P) binding site [chemical binding]; other site
378806022623	active site
378806022624	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
378806022625	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
378806022626	TPR repeat; Region: TPR_11; pfam13414
378806022627	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806022628	binding surface
378806022629	TPR motif; other site
378806022630	PEGA domain; Region: PEGA; pfam08308
378806022631	PEGA domain; Region: PEGA; pfam08308
378806022632	PEGA domain; Region: PEGA; pfam08308
378806022633	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
378806022634	N-terminal plug; other site
378806022635	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
378806022636	ligand-binding site [chemical binding]; other site
378806022637	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
378806022638	nudix motif; other site
378806022639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806022640	Coenzyme A binding pocket [chemical binding]; other site
378806022641	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
378806022642	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
378806022643	HD domain; Region: HD_3; pfam13023
378806022644	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
378806022645	nudix motif; other site
378806022646	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
378806022647	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
378806022648	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
378806022649	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
378806022650	Tubby C 2; Region: Tub_2; cl02043
378806022651	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
378806022652	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
378806022653	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
378806022654	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
378806022655	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022656	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022657	active site
378806022658	ATP binding site [chemical binding]; other site
378806022659	substrate binding site [chemical binding]; other site
378806022660	activation loop (A-loop); other site
378806022661	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
378806022662	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
378806022663	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
378806022664	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806022665	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806022666	DNA-binding site [nucleotide binding]; DNA binding site
378806022667	TIR domain; Region: TIR_2; pfam13676
378806022668	AAA ATPase domain; Region: AAA_16; pfam13191
378806022669	NACHT domain; Region: NACHT; pfam05729
378806022670	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806022671	structural tetrad; other site
378806022672	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806022673	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806022674	structural tetrad; other site
378806022675	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806022676	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
378806022677	structural tetrad; other site
378806022678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806022679	Methyltransferase domain; Region: Methyltransf_23; pfam13489
378806022680	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
378806022681	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
378806022682	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
378806022683	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
378806022684	active site
378806022685	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
378806022686	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
378806022687	DXD motif; other site
378806022688	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
378806022689	Response regulator receiver domain; Region: Response_reg; pfam00072
378806022690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022691	active site
378806022692	phosphorylation site [posttranslational modification]
378806022693	intermolecular recognition site; other site
378806022694	dimerization interface [polypeptide binding]; other site
378806022695	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
378806022696	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
378806022697	SLBB domain; Region: SLBB; pfam10531
378806022698	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
378806022699	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
378806022700	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
378806022701	Bacterial sugar transferase; Region: Bac_transf; pfam02397
378806022702	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806022703	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
378806022704	Response regulator receiver domain; Region: Response_reg; pfam00072
378806022705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022706	active site
378806022707	phosphorylation site [posttranslational modification]
378806022708	intermolecular recognition site; other site
378806022709	dimerization interface [polypeptide binding]; other site
378806022710	GAF domain; Region: GAF_3; pfam13492
378806022711	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806022712	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
378806022713	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
378806022714	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
378806022715	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
378806022716	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
378806022717	putative NADH binding site [chemical binding]; other site
378806022718	putative active site [active]
378806022719	nudix motif; other site
378806022720	putative metal binding site [ion binding]; other site
378806022721	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
378806022722	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806022723	FeS/SAM binding site; other site
378806022724	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
378806022725	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806022726	PAS fold; Region: PAS_3; pfam08447
378806022727	putative active site [active]
378806022728	heme pocket [chemical binding]; other site
378806022729	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022730	dimer interface [polypeptide binding]; other site
378806022731	phosphorylation site [posttranslational modification]
378806022732	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022733	ATP binding site [chemical binding]; other site
378806022734	Mg2+ binding site [ion binding]; other site
378806022735	G-X-G motif; other site
378806022736	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806022737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022738	active site
378806022739	phosphorylation site [posttranslational modification]
378806022740	intermolecular recognition site; other site
378806022741	dimerization interface [polypeptide binding]; other site
378806022742	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
378806022743	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
378806022744	active site
378806022745	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
378806022746	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
378806022747	tetramer interface [polypeptide binding]; other site
378806022748	heme binding pocket [chemical binding]; other site
378806022749	Double zinc ribbon; Region: DZR; pfam12773
378806022750	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806022751	TAP-like protein; Region: Abhydrolase_4; pfam08386
378806022752	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022753	dimer interface [polypeptide binding]; other site
378806022754	phosphorylation site [posttranslational modification]
378806022755	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022756	ATP binding site [chemical binding]; other site
378806022757	G-X-G motif; other site
378806022758	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
378806022759	GIY-YIG motif/motif A; other site
378806022760	putative active site [active]
378806022761	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
378806022762	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
378806022763	SurA N-terminal domain; Region: SurA_N_3; cl07813
378806022764	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
378806022765	SurA N-terminal domain; Region: SurA_N; pfam09312
378806022766	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
378806022767	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
378806022768	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
378806022769	FAD binding domain; Region: FAD_binding_4; pfam01565
378806022770	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
378806022771	intracellular protease, PfpI family; Region: PfpI; TIGR01382
378806022772	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
378806022773	conserved cys residue [active]
378806022774	FG-GAP repeat; Region: FG-GAP_2; pfam14312
378806022775	FG-GAP repeat; Region: FG-GAP_2; pfam14312
378806022776	FG-GAP repeat; Region: FG-GAP_2; pfam14312
378806022777	FG-GAP repeat; Region: FG-GAP_2; pfam14312
378806022778	FG-GAP repeat; Region: FG-GAP_2; pfam14312
378806022779	FG-GAP repeat; Region: FG-GAP_2; pfam14312
378806022780	FG-GAP repeat; Region: FG-GAP_2; pfam14312
378806022781	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806022782	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
378806022783	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
378806022784	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806022785	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806022786	DNA-binding site [nucleotide binding]; DNA binding site
378806022787	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
378806022788	EamA-like transporter family; Region: EamA; pfam00892
378806022789	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806022790	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
378806022791	active site
378806022792	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
378806022793	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806022794	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806022795	DNA-binding site [nucleotide binding]; DNA binding site
378806022796	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806022797	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022798	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022799	active site
378806022800	ATP binding site [chemical binding]; other site
378806022801	substrate binding site [chemical binding]; other site
378806022802	activation loop (A-loop); other site
378806022803	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806022804	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
378806022805	amidase catalytic site [active]
378806022806	Zn binding residues [ion binding]; other site
378806022807	substrate binding site [chemical binding]; other site
378806022808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
378806022809	Chitin binding domain; Region: Chitin_bind_3; pfam03067
378806022810	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
378806022811	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
378806022812	active site
378806022813	substrate binding site [chemical binding]; other site
378806022814	Mg2+ binding site [ion binding]; other site
378806022815	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
378806022816	potassium uptake protein; Region: kup; TIGR00794
378806022817	K+ potassium transporter; Region: K_trans; pfam02705
378806022818	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
378806022819	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806022820	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
378806022821	DNA binding residues [nucleotide binding]
378806022822	Antirepressor CarS; Region: CarS; cd12840
378806022823	putative repressor interaction site [polypeptide binding]; other site
378806022824	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
378806022825	SPFH domain / Band 7 family; Region: Band_7; pfam01145
378806022826	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806022827	activation loop (A-loop); other site
378806022828	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
378806022829	Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709
378806022830	adenylosuccinate synthetase; Provisional; Region: PRK13786
378806022831	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806022832	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806022833	phosphopeptide binding site; other site
378806022834	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
378806022835	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
378806022836	substrate binding pocket [chemical binding]; other site
378806022837	chain length determination region; other site
378806022838	substrate-Mg2+ binding site; other site
378806022839	catalytic residues [active]
378806022840	aspartate-rich region 1; other site
378806022841	active site lid residues [active]
378806022842	aspartate-rich region 2; other site
378806022843	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
378806022844	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
378806022845	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806022846	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022847	active site
378806022848	ATP binding site [chemical binding]; other site
378806022849	substrate binding site [chemical binding]; other site
378806022850	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806022851	substrate binding site [chemical binding]; other site
378806022852	activation loop (A-loop); other site
378806022853	activation loop (A-loop); other site
378806022854	AAA ATPase domain; Region: AAA_16; pfam13191
378806022855	Methyltransferase domain; Region: Methyltransf_31; pfam13847
378806022856	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806022857	S-adenosylmethionine binding site [chemical binding]; other site
378806022858	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
378806022859	active site
378806022860	Protein kinase domain; Region: Pkinase; pfam00069
378806022861	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022862	active site
378806022863	ATP binding site [chemical binding]; other site
378806022864	substrate binding site [chemical binding]; other site
378806022865	activation loop (A-loop); other site
378806022866	PLD-like domain; Region: PLDc_2; pfam13091
378806022867	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
378806022868	putative active site [active]
378806022869	catalytic site [active]
378806022870	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
378806022871	PLD-like domain; Region: PLDc_2; pfam13091
378806022872	putative active site [active]
378806022873	catalytic site [active]
378806022874	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
378806022875	classical (c) SDRs; Region: SDR_c; cd05233
378806022876	NAD(P) binding site [chemical binding]; other site
378806022877	active site
378806022878	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806022879	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022880	dimer interface [polypeptide binding]; other site
378806022881	phosphorylation site [posttranslational modification]
378806022882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022883	ATP binding site [chemical binding]; other site
378806022884	Mg2+ binding site [ion binding]; other site
378806022885	G-X-G motif; other site
378806022886	Response regulator receiver domain; Region: Response_reg; pfam00072
378806022887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022888	active site
378806022889	phosphorylation site [posttranslational modification]
378806022890	intermolecular recognition site; other site
378806022891	dimerization interface [polypeptide binding]; other site
378806022892	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806022893	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022894	dimer interface [polypeptide binding]; other site
378806022895	phosphorylation site [posttranslational modification]
378806022896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022897	ATP binding site [chemical binding]; other site
378806022898	Mg2+ binding site [ion binding]; other site
378806022899	G-X-G motif; other site
378806022900	Response regulator receiver domain; Region: Response_reg; pfam00072
378806022901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022902	active site
378806022903	phosphorylation site [posttranslational modification]
378806022904	intermolecular recognition site; other site
378806022905	dimerization interface [polypeptide binding]; other site
378806022906	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
378806022907	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806022908	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806022909	DNA-binding site [nucleotide binding]; DNA binding site
378806022910	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806022911	DDE superfamily endonuclease; Region: DDE_5; cl17874
378806022912	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806022913	Protein of unknown function (DUF2379); Region: DUF2379; pfam09543
378806022914	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806022915	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022916	active site
378806022917	ATP binding site [chemical binding]; other site
378806022918	substrate binding site [chemical binding]; other site
378806022919	activation loop (A-loop); other site
378806022920	AAA ATPase domain; Region: AAA_16; pfam13191
378806022921	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806022922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022923	active site
378806022924	phosphorylation site [posttranslational modification]
378806022925	intermolecular recognition site; other site
378806022926	dimerization interface [polypeptide binding]; other site
378806022927	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
378806022928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022929	ATP binding site [chemical binding]; other site
378806022930	Mg2+ binding site [ion binding]; other site
378806022931	G-X-G motif; other site
378806022932	Response regulator receiver domain; Region: Response_reg; pfam00072
378806022933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022934	active site
378806022935	phosphorylation site [posttranslational modification]
378806022936	intermolecular recognition site; other site
378806022937	dimerization interface [polypeptide binding]; other site
378806022938	Response regulator receiver domain; Region: Response_reg; pfam00072
378806022939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022940	active site
378806022941	phosphorylation site [posttranslational modification]
378806022942	intermolecular recognition site; other site
378806022943	dimerization interface [polypeptide binding]; other site
378806022944	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022945	dimer interface [polypeptide binding]; other site
378806022946	phosphorylation site [posttranslational modification]
378806022947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022948	ATP binding site [chemical binding]; other site
378806022949	Mg2+ binding site [ion binding]; other site
378806022950	G-X-G motif; other site
378806022951	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
378806022952	Response regulator receiver domain; Region: Response_reg; pfam00072
378806022953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806022954	active site
378806022955	phosphorylation site [posttranslational modification]
378806022956	intermolecular recognition site; other site
378806022957	dimerization interface [polypeptide binding]; other site
378806022958	Protein of unknown function DUF72; Region: DUF72; pfam01904
378806022959	CARDB; Region: CARDB; pfam07705
378806022960	CARDB; Region: CARDB; pfam07705
378806022961	CARDB; Region: CARDB; pfam07705
378806022962	CARDB; Region: CARDB; pfam07705
378806022963	Protein of unknown function (DUF2378); Region: DUF2378; cl15288
378806022964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806022965	AAA domain; Region: AAA_21; pfam13304
378806022966	Walker A/P-loop; other site
378806022967	ATP binding site [chemical binding]; other site
378806022968	Cation efflux family; Region: Cation_efflux; cl00316
378806022969	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
378806022970	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
378806022971	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
378806022972	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
378806022973	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
378806022974	active site
378806022975	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
378806022976	GtrA-like protein; Region: GtrA; pfam04138
378806022977	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
378806022978	active site
378806022979	catalytic residues [active]
378806022980	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
378806022981	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806022982	active site
378806022983	ATP binding site [chemical binding]; other site
378806022984	substrate binding site [chemical binding]; other site
378806022985	substrate binding site [chemical binding]; other site
378806022986	activation loop (A-loop); other site
378806022987	activation loop (A-loop); other site
378806022988	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806022989	AAA ATPase domain; Region: AAA_16; pfam13191
378806022990	Predicted ATPase [General function prediction only]; Region: COG3899
378806022991	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806022992	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806022993	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806022994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806022995	dimer interface [polypeptide binding]; other site
378806022996	phosphorylation site [posttranslational modification]
378806022997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806022998	ATP binding site [chemical binding]; other site
378806022999	Mg2+ binding site [ion binding]; other site
378806023000	G-X-G motif; other site
378806023001	OsmC-like protein; Region: OsmC; pfam02566
378806023002	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806023003	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023004	active site
378806023005	ATP binding site [chemical binding]; other site
378806023006	substrate binding site [chemical binding]; other site
378806023007	activation loop (A-loop); other site
378806023008	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806023009	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023010	active site
378806023011	ATP binding site [chemical binding]; other site
378806023012	substrate binding site [chemical binding]; other site
378806023013	activation loop (A-loop); other site
378806023014	Predicted exporter [General function prediction only]; Region: COG4258
378806023015	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
378806023016	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
378806023017	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
378806023018	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
378806023019	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
378806023020	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
378806023021	active site
378806023022	catalytic site [active]
378806023023	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023024	active site
378806023025	ATP binding site [chemical binding]; other site
378806023026	substrate binding site [chemical binding]; other site
378806023027	activation loop (A-loop); other site
378806023028	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806023029	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023030	active site
378806023031	ATP binding site [chemical binding]; other site
378806023032	substrate binding site [chemical binding]; other site
378806023033	activation loop (A-loop); other site
378806023034	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
378806023035	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
378806023036	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
378806023037	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
378806023038	active site
378806023039	Zn binding site [ion binding]; other site
378806023040	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
378806023041	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
378806023042	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
378806023043	active site
378806023044	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
378806023045	Sphingolipid Delta4-desaturase (DES); Region: Lipid_DES; pfam08557
378806023046	sphingolipid delta-4 desaturase; Region: PLN02579
378806023047	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
378806023048	putative di-iron ligands [ion binding]; other site
378806023049	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
378806023050	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
378806023051	catalytic loop [active]
378806023052	iron binding site [ion binding]; other site
378806023053	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
378806023054	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
378806023055	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806023056	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
378806023057	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806023058	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
378806023059	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
378806023060	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
378806023061	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806023062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806023063	active site
378806023064	phosphorylation site [posttranslational modification]
378806023065	intermolecular recognition site; other site
378806023066	dimerization interface [polypeptide binding]; other site
378806023067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806023068	PAS domain; Region: PAS_9; pfam13426
378806023069	putative active site [active]
378806023070	heme pocket [chemical binding]; other site
378806023071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806023072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023073	dimer interface [polypeptide binding]; other site
378806023074	phosphorylation site [posttranslational modification]
378806023075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023076	ATP binding site [chemical binding]; other site
378806023077	Mg2+ binding site [ion binding]; other site
378806023078	G-X-G motif; other site
378806023079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806023080	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806023081	active site
378806023082	phosphorylation site [posttranslational modification]
378806023083	intermolecular recognition site; other site
378806023084	dimerization interface [polypeptide binding]; other site
378806023085	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
378806023086	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806023087	Phytochrome region; Region: PHY; pfam00360
378806023088	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023089	dimer interface [polypeptide binding]; other site
378806023090	phosphorylation site [posttranslational modification]
378806023091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023092	ATP binding site [chemical binding]; other site
378806023093	Mg2+ binding site [ion binding]; other site
378806023094	G-X-G motif; other site
378806023095	Response regulator receiver domain; Region: Response_reg; pfam00072
378806023096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806023097	active site
378806023098	phosphorylation site [posttranslational modification]
378806023099	intermolecular recognition site; other site
378806023100	dimerization interface [polypeptide binding]; other site
378806023101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806023102	PAS fold; Region: PAS_3; pfam08447
378806023103	putative active site [active]
378806023104	heme pocket [chemical binding]; other site
378806023105	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806023106	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023107	dimer interface [polypeptide binding]; other site
378806023108	phosphorylation site [posttranslational modification]
378806023109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023110	ATP binding site [chemical binding]; other site
378806023111	Mg2+ binding site [ion binding]; other site
378806023112	G-X-G motif; other site
378806023113	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
378806023114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806023115	active site
378806023116	phosphorylation site [posttranslational modification]
378806023117	intermolecular recognition site; other site
378806023118	dimerization interface [polypeptide binding]; other site
378806023119	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023120	dimer interface [polypeptide binding]; other site
378806023121	phosphorylation site [posttranslational modification]
378806023122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023123	ATP binding site [chemical binding]; other site
378806023124	Mg2+ binding site [ion binding]; other site
378806023125	G-X-G motif; other site
378806023126	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
378806023127	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
378806023128	active site
378806023129	catalytic tetrad [active]
378806023130	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
378806023131	ligand-binding site [chemical binding]; other site
378806023132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806023133	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
378806023134	Walker A/P-loop; other site
378806023135	ATP binding site [chemical binding]; other site
378806023136	Q-loop/lid; other site
378806023137	ABC transporter signature motif; other site
378806023138	Walker B; other site
378806023139	D-loop; other site
378806023140	H-loop/switch region; other site
378806023141	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
378806023142	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
378806023143	metal binding triad [ion binding]; metal-binding site
378806023144	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
378806023145	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
378806023146	active site
378806023147	metal binding site [ion binding]; metal-binding site
378806023148	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
378806023149	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
378806023150	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
378806023151	acyl-activating enzyme (AAE) consensus motif; other site
378806023152	AMP binding site [chemical binding]; other site
378806023153	active site
378806023154	CoA binding site [chemical binding]; other site
378806023155	Phosphopantetheine attachment site; Region: PP-binding; cl09936
378806023156	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
378806023157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806023158	FeS/SAM binding site; other site
378806023159	HemN C-terminal domain; Region: HemN_C; pfam06969
378806023160	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
378806023161	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
378806023162	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
378806023163	NADP binding site [chemical binding]; other site
378806023164	substrate binding site [chemical binding]; other site
378806023165	active site
378806023166	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
378806023167	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
378806023168	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
378806023169	metal binding triad [ion binding]; metal-binding site
378806023170	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
378806023171	classical (c) SDRs; Region: SDR_c; cd05233
378806023172	NAD(P) binding site [chemical binding]; other site
378806023173	active site
378806023174	AAA-like domain; Region: AAA_10; pfam12846
378806023175	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
378806023176	putative active site [active]
378806023177	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
378806023178	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
378806023179	Imelysin; Region: Peptidase_M75; pfam09375
378806023180	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806023181	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806023182	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806023183	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806023184	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
378806023185	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
378806023186	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806023187	phenylhydantoinase; Validated; Region: PRK08323
378806023188	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
378806023189	tetramer interface [polypeptide binding]; other site
378806023190	active site
378806023191	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
378806023192	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
378806023193	active site
378806023194	catalytic triad [active]
378806023195	dimer interface [polypeptide binding]; other site
378806023196	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
378806023197	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806023198	inhibitor-cofactor binding pocket; inhibition site
378806023199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806023200	catalytic residue [active]
378806023201	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
378806023202	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
378806023203	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
378806023204	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
378806023205	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
378806023206	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
378806023207	homodimer interface [polypeptide binding]; other site
378806023208	active site
378806023209	FMN binding site [chemical binding]; other site
378806023210	substrate binding site [chemical binding]; other site
378806023211	4Fe-4S binding domain; Region: Fer4; pfam00037
378806023212	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
378806023213	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
378806023214	Na binding site [ion binding]; other site
378806023215	putative substrate binding site [chemical binding]; other site
378806023216	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806023217	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
378806023218	Amidohydrolase; Region: Amidohydro_4; pfam13147
378806023219	active site
378806023220	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
378806023221	catalytic residues [active]
378806023222	dimer interface [polypeptide binding]; other site
378806023223	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
378806023224	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
378806023225	Walker A motif; other site
378806023226	ATP binding site [chemical binding]; other site
378806023227	Walker B motif; other site
378806023228	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
378806023229	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806023230	putative active site [active]
378806023231	putative metal binding site [ion binding]; other site
378806023232	classical (c) SDRs; Region: SDR_c; cd05233
378806023233	short chain dehydrogenase; Provisional; Region: PRK07041
378806023234	NAD(P) binding site [chemical binding]; other site
378806023235	active site
378806023236	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
378806023237	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
378806023238	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
378806023239	calcium binding site 2 [ion binding]; other site
378806023240	active site
378806023241	catalytic triad [active]
378806023242	calcium binding site 1 [ion binding]; other site
378806023243	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806023244	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806023245	putative sugar binding sites [chemical binding]; other site
378806023246	Q-X-W motif; other site
378806023247	Transcriptional regulator [Transcription]; Region: LysR; COG0583
378806023248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
378806023249	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
378806023250	putative effector binding pocket; other site
378806023251	putative dimerization interface [polypeptide binding]; other site
378806023252	short chain dehydrogenase; Provisional; Region: PRK06180
378806023253	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
378806023254	NADP binding site [chemical binding]; other site
378806023255	active site
378806023256	steroid binding site; other site
378806023257	GTP-binding protein YchF; Reviewed; Region: PRK09601
378806023258	YchF GTPase; Region: YchF; cd01900
378806023259	G1 box; other site
378806023260	GTP/Mg2+ binding site [chemical binding]; other site
378806023261	Switch I region; other site
378806023262	G2 box; other site
378806023263	Switch II region; other site
378806023264	G3 box; other site
378806023265	G4 box; other site
378806023266	G5 box; other site
378806023267	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
378806023268	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
378806023269	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
378806023270	ATP synthase subunit C; Region: ATP-synt_C; cl00466
378806023271	ATP synthase A chain; Region: ATP-synt_A; cl00413
378806023272	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
378806023273	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
378806023274	PAS fold; Region: PAS; pfam00989
378806023275	PAS domain; Region: PAS; smart00091
378806023276	putative active site [active]
378806023277	heme pocket [chemical binding]; other site
378806023278	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806023279	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806023280	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
378806023281	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806023282	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023283	dimer interface [polypeptide binding]; other site
378806023284	phosphorylation site [posttranslational modification]
378806023285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023286	ATP binding site [chemical binding]; other site
378806023287	Mg2+ binding site [ion binding]; other site
378806023288	G-X-G motif; other site
378806023289	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
378806023290	hypothetical protein; Provisional; Region: PRK12378
378806023291	PEGA domain; Region: PEGA; pfam08308
378806023292	Haemolytic domain; Region: Haemolytic; pfam01809
378806023293	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
378806023294	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
378806023295	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
378806023296	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
378806023297	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
378806023298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
378806023299	S-adenosylmethionine binding site [chemical binding]; other site
378806023300	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
378806023301	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
378806023302	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806023303	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806023304	DNA-binding site [nucleotide binding]; DNA binding site
378806023305	FCD domain; Region: FCD; cl11656
378806023306	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806023307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023308	dimer interface [polypeptide binding]; other site
378806023309	phosphorylation site [posttranslational modification]
378806023310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023311	ATP binding site [chemical binding]; other site
378806023312	Mg2+ binding site [ion binding]; other site
378806023313	G-X-G motif; other site
378806023314	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806023315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806023316	active site
378806023317	phosphorylation site [posttranslational modification]
378806023318	intermolecular recognition site; other site
378806023319	dimerization interface [polypeptide binding]; other site
378806023320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806023321	Walker A motif; other site
378806023322	ATP binding site [chemical binding]; other site
378806023323	Walker B motif; other site
378806023324	arginine finger; other site
378806023325	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
378806023326	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
378806023327	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
378806023328	Protein kinase domain; Region: Pkinase; pfam00069
378806023329	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023330	active site
378806023331	ATP binding site [chemical binding]; other site
378806023332	substrate binding site [chemical binding]; other site
378806023333	activation loop (A-loop); other site
378806023334	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806023335	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
378806023336	Walker A motif; other site
378806023337	ATP binding site [chemical binding]; other site
378806023338	Walker B motif; other site
378806023339	arginine finger; other site
378806023340	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
378806023341	B12 binding domain; Region: B12-binding; pfam02310
378806023342	B12 binding site [chemical binding]; other site
378806023343	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
378806023344	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
378806023345	FeS/SAM binding site; other site
378806023346	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806023347	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023348	active site
378806023349	ATP binding site [chemical binding]; other site
378806023350	substrate binding site [chemical binding]; other site
378806023351	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806023352	substrate binding site [chemical binding]; other site
378806023353	activation loop (A-loop); other site
378806023354	activation loop (A-loop); other site
378806023355	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
378806023356	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806023357	inhibitor-cofactor binding pocket; inhibition site
378806023358	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806023359	catalytic residue [active]
378806023360	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
378806023361	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806023362	AAA domain; Region: AAA_31; pfam13614
378806023363	P-loop; other site
378806023364	Magnesium ion binding site [ion binding]; other site
378806023365	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
378806023366	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
378806023367	Transposase; Region: DDE_Tnp_ISL3; pfam01610
378806023368	Transposase; Region: DDE_Tnp_ISL3; pfam01610
378806023369	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
378806023370	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
378806023371	active site
378806023372	motif I; other site
378806023373	motif II; other site
378806023374	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
378806023375	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
378806023376	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
378806023377	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
378806023378	putative catalytic site [active]
378806023379	putative metal binding site [ion binding]; other site
378806023380	putative phosphate binding site [ion binding]; other site
378806023381	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
378806023382	Protein of unknown function DUF82; Region: DUF82; pfam01927
378806023383	Uncharacterized conserved protein [Function unknown]; Region: COG1656
378806023384	Methyltransferase domain; Region: Methyltransf_11; pfam08241
378806023385	S-adenosylmethionine binding site [chemical binding]; other site
378806023386	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
378806023387	DNA binding residues [nucleotide binding]
378806023388	dimerization interface [polypeptide binding]; other site
378806023389	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
378806023390	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
378806023391	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806023392	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
378806023393	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806023394	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806023395	phosphopeptide binding site; other site
378806023396	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806023397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806023398	Walker A motif; other site
378806023399	ATP binding site [chemical binding]; other site
378806023400	Walker B motif; other site
378806023401	arginine finger; other site
378806023402	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
378806023403	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
378806023404	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806023405	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
378806023406	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
378806023407	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
378806023408	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806023409	putative active site [active]
378806023410	heme pocket [chemical binding]; other site
378806023411	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023412	dimer interface [polypeptide binding]; other site
378806023413	phosphorylation site [posttranslational modification]
378806023414	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023415	ATP binding site [chemical binding]; other site
378806023416	Mg2+ binding site [ion binding]; other site
378806023417	G-X-G motif; other site
378806023418	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
378806023419	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806023420	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806023421	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
378806023422	NIL domain; Region: NIL; cl09633
378806023423	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
378806023424	amidase catalytic site [active]
378806023425	Zn binding residues [ion binding]; other site
378806023426	substrate binding site [chemical binding]; other site
378806023427	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
378806023428	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806023429	Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393
378806023430	putative active site [active]
378806023431	putative metal binding site [ion binding]; other site
378806023432	Predicted ATPase [General function prediction only]; Region: COG4637
378806023433	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806023434	Walker A/P-loop; other site
378806023435	ATP binding site [chemical binding]; other site
378806023436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
378806023437	ABC transporter signature motif; other site
378806023438	Walker B; other site
378806023439	D-loop; other site
378806023440	H-loop/switch region; other site
378806023441	ATP-grasp domain; Region: ATP-grasp_4; cl17255
378806023442	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806023443	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023444	dimer interface [polypeptide binding]; other site
378806023445	phosphorylation site [posttranslational modification]
378806023446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023447	ATP binding site [chemical binding]; other site
378806023448	Mg2+ binding site [ion binding]; other site
378806023449	G-X-G motif; other site
378806023450	Response regulator receiver domain; Region: Response_reg; pfam00072
378806023451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806023452	active site
378806023453	phosphorylation site [posttranslational modification]
378806023454	intermolecular recognition site; other site
378806023455	dimerization interface [polypeptide binding]; other site
378806023456	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806023457	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023458	dimer interface [polypeptide binding]; other site
378806023459	phosphorylation site [posttranslational modification]
378806023460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023461	ATP binding site [chemical binding]; other site
378806023462	Mg2+ binding site [ion binding]; other site
378806023463	G-X-G motif; other site
378806023464	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806023465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023466	dimer interface [polypeptide binding]; other site
378806023467	phosphorylation site [posttranslational modification]
378806023468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023469	ATP binding site [chemical binding]; other site
378806023470	Mg2+ binding site [ion binding]; other site
378806023471	G-X-G motif; other site
378806023472	Response regulator receiver domain; Region: Response_reg; pfam00072
378806023473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806023474	active site
378806023475	phosphorylation site [posttranslational modification]
378806023476	intermolecular recognition site; other site
378806023477	dimerization interface [polypeptide binding]; other site
378806023478	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
378806023479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023480	dimer interface [polypeptide binding]; other site
378806023481	phosphorylation site [posttranslational modification]
378806023482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023483	ATP binding site [chemical binding]; other site
378806023484	Mg2+ binding site [ion binding]; other site
378806023485	G-X-G motif; other site
378806023486	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
378806023487	potassium uptake protein; Region: kup; TIGR00794
378806023488	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
378806023489	heme-binding site [chemical binding]; other site
378806023490	5'-3' exonuclease; Region: 53EXOc; smart00475
378806023491	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
378806023492	active site
378806023493	metal binding site 1 [ion binding]; metal-binding site
378806023494	putative 5' ssDNA interaction site; other site
378806023495	metal binding site 3; metal-binding site
378806023496	metal binding site 2 [ion binding]; metal-binding site
378806023497	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
378806023498	putative DNA binding site [nucleotide binding]; other site
378806023499	putative metal binding site [ion binding]; other site
378806023500	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
378806023501	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
378806023502	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
378806023503	ligand binding site [chemical binding]; other site
378806023504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
378806023505	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
378806023506	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
378806023507	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
378806023508	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
378806023509	putative ADP-ribose binding site [chemical binding]; other site
378806023510	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
378806023511	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
378806023512	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
378806023513	Coenzyme A transferase; Region: CoA_trans; cl17247
378806023514	putative alcohol dehydrogenase; Provisional; Region: PRK13771
378806023515	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
378806023516	NAD(P) binding site [chemical binding]; other site
378806023517	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
378806023518	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
378806023519	dimer interface [polypeptide binding]; other site
378806023520	active site
378806023521	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806023522	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806023523	DNA-binding site [nucleotide binding]; DNA binding site
378806023524	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
378806023525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806023526	Coenzyme A binding pocket [chemical binding]; other site
378806023527	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
378806023528	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
378806023529	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
378806023530	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
378806023531	Cna protein B-type domain; Region: Cna_B_2; pfam13715
378806023532	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
378806023533	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806023534	starch binding outer membrane protein SusD; Region: SusD; cd08977
378806023535	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
378806023536	Peptidase family M28; Region: Peptidase_M28; pfam04389
378806023537	active site
378806023538	metal binding site [ion binding]; metal-binding site
378806023539	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023540	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806023541	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023542	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023543	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023544	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023545	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023546	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806023547	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
378806023548	metal binding triad [ion binding]; metal-binding site
378806023549	Archaeal ATPase; Region: Arch_ATPase; pfam01637
378806023550	AAA ATPase domain; Region: AAA_16; pfam13191
378806023551	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
378806023552	glycogen binding site [chemical binding]; other site
378806023553	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
378806023554	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
378806023555	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806023556	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023557	active site
378806023558	ATP binding site [chemical binding]; other site
378806023559	substrate binding site [chemical binding]; other site
378806023560	activation loop (A-loop); other site
378806023561	WD domain, G-beta repeat; Region: WD40; pfam00400
378806023562	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806023563	structural tetrad; other site
378806023564	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
378806023565	FOG: WD40 repeat [General function prediction only]; Region: COG2319
378806023566	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
378806023567	structural tetrad; other site
378806023568	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
378806023569	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806023570	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
378806023571	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
378806023572	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
378806023573	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
378806023574	ATP binding site [chemical binding]; other site
378806023575	Mg++ binding site [ion binding]; other site
378806023576	motif III; other site
378806023577	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806023578	nucleotide binding region [chemical binding]; other site
378806023579	ATP-binding site [chemical binding]; other site
378806023580	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
378806023581	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
378806023582	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
378806023583	putative NAD(P) binding site [chemical binding]; other site
378806023584	dimer interface [polypeptide binding]; other site
378806023585	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
378806023586	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
378806023587	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
378806023588	active site
378806023589	dimer interface [polypeptide binding]; other site
378806023590	P-loop containing region of AAA domain; Region: AAA_29; cl17516
378806023591	AAA domain; Region: AAA_21; pfam13304
378806023592	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
378806023593	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806023594	VanW like protein; Region: VanW; pfam04294
378806023595	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
378806023596	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
378806023597	putative [Fe4-S4] binding site [ion binding]; other site
378806023598	putative molybdopterin cofactor binding site [chemical binding]; other site
378806023599	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
378806023600	molybdopterin cofactor binding site; other site
378806023601	Right handed beta helix region; Region: Beta_helix; pfam13229
378806023602	Trehalase; Region: Trehalase; cl17346
378806023603	CBD_II domain; Region: CBD_II; smart00637
378806023604	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
378806023605	active site
378806023606	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
378806023607	XdhC Rossmann domain; Region: XdhC_C; pfam13478
378806023608	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
378806023609	Ligand binding site; other site
378806023610	metal-binding site
378806023611	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
378806023612	Phage Tail Collar Domain; Region: Collar; pfam07484
378806023613	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
378806023614	Domain of unknown function DUF20; Region: UPF0118; pfam01594
378806023615	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
378806023616	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
378806023617	Transposase; Region: DEDD_Tnp_IS110; pfam01548
378806023618	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806023619	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
378806023620	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
378806023621	amidase catalytic site [active]
378806023622	Zn binding residues [ion binding]; other site
378806023623	substrate binding site [chemical binding]; other site
378806023624	Outer membrane efflux protein; Region: OEP; pfam02321
378806023625	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
378806023626	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
378806023627	HlyD family secretion protein; Region: HlyD_3; pfam13437
378806023628	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
378806023629	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
378806023630	Malic enzyme, N-terminal domain; Region: malic; pfam00390
378806023631	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
378806023632	putative NAD(P) binding site [chemical binding]; other site
378806023633	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
378806023634	DEAD-like helicases superfamily; Region: DEXDc; smart00487
378806023635	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
378806023636	ATP binding site [chemical binding]; other site
378806023637	putative Mg++ binding site [ion binding]; other site
378806023638	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
378806023639	nucleotide binding region [chemical binding]; other site
378806023640	ATP-binding site [chemical binding]; other site
378806023641	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806023642	Coenzyme A binding pocket [chemical binding]; other site
378806023643	Beta-lactamase; Region: Beta-lactamase; cl17358
378806023644	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
378806023645	Predicted transcriptional regulator [Transcription]; Region: COG5340
378806023646	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
378806023647	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
378806023648	putative active site [active]
378806023649	putative metal binding site [ion binding]; other site
378806023650	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806023651	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
378806023652	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
378806023653	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
378806023654	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
378806023655	inhibitor-cofactor binding pocket; inhibition site
378806023656	pyridoxal 5'-phosphate binding site [chemical binding]; other site
378806023657	catalytic residue [active]
378806023658	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
378806023659	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
378806023660	Protein of unknown function, DUF482; Region: DUF482; pfam04339
378806023661	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
378806023662	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
378806023663	Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983
378806023664	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
378806023665	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
378806023666	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
378806023667	putative sugar binding sites [chemical binding]; other site
378806023668	Q-X-W motif; other site
378806023669	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
378806023670	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
378806023671	intermolecular salt bridges; other site
378806023672	calcium mediated ligand binding site; other site
378806023673	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023674	Protein kinase domain; Region: Pkinase; pfam00069
378806023675	active site
378806023676	ATP binding site [chemical binding]; other site
378806023677	substrate binding site [chemical binding]; other site
378806023678	activation loop (A-loop); other site
378806023679	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
378806023680	Rubrerythrin [Energy production and conversion]; Region: COG1592
378806023681	dinuclear metal binding motif [ion binding]; other site
378806023682	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806023683	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806023684	DNA-binding site [nucleotide binding]; DNA binding site
378806023685	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
378806023686	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
378806023687	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
378806023688	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
378806023689	Radical SAM superfamily; Region: Radical_SAM; pfam04055
378806023690	FeS/SAM binding site; other site
378806023691	O-methyltransferase; Region: Methyltransf_2; pfam00891
378806023692	putative phosphoketolase; Provisional; Region: PRK05261
378806023693	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
378806023694	TPP-binding site; other site
378806023695	XFP C-terminal domain; Region: XFP_C; pfam09363
378806023696	Acetokinase family; Region: Acetate_kinase; cl17229
378806023697	propionate/acetate kinase; Provisional; Region: PRK12379
378806023698	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
378806023699	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
378806023700	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
378806023701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
378806023702	active site
378806023703	phosphorylation site [posttranslational modification]
378806023704	intermolecular recognition site; other site
378806023705	dimerization interface [polypeptide binding]; other site
378806023706	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
378806023707	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
378806023708	active site
378806023709	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806023710	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
378806023711	Coenzyme A binding pocket [chemical binding]; other site
378806023712	Family description; Region: VCBS; pfam13517
378806023713	Family description; Region: VCBS; pfam13517
378806023714	Family description; Region: VCBS; pfam13517
378806023715	Family description; Region: VCBS; pfam13517
378806023716	CARDB; Region: CARDB; pfam07705
378806023717	CARDB; Region: CARDB; pfam07705
378806023718	CARDB; Region: CARDB; pfam07705
378806023719	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
378806023720	PIN domain; Region: PIN_3; pfam13470
378806023721	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
378806023722	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
378806023723	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
378806023724	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
378806023725	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
378806023726	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
378806023727	Family description; Region: VCBS; pfam13517
378806023728	Family description; Region: VCBS; pfam13517
378806023729	Family description; Region: VCBS; pfam13517
378806023730	Family description; Region: VCBS; pfam13517
378806023731	Family description; Region: VCBS; pfam13517
378806023732	Family description; Region: VCBS; pfam13517
378806023733	Family description; Region: VCBS; pfam13517
378806023734	Family description; Region: VCBS; pfam13517
378806023735	Family description; Region: VCBS; pfam13517
378806023736	Family description; Region: VCBS; pfam13517
378806023737	Family description; Region: VCBS; pfam13517
378806023738	Family description; Region: VCBS; pfam13517
378806023739	Family description; Region: VCBS; pfam13517
378806023740	Family description; Region: VCBS; pfam13517
378806023741	Family description; Region: VCBS; pfam13517
378806023742	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
378806023743	putative catalytic residue [active]
378806023744	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
378806023745	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
378806023746	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
378806023747	DsbD alpha interface [polypeptide binding]; other site
378806023748	catalytic residues [active]
378806023749	Predicted membrane protein (DUF2335); Region: DUF2335; cl02210
378806023750	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
378806023751	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
378806023752	metal ion-dependent adhesion site (MIDAS); other site
378806023753	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
378806023754	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
378806023755	Beta/Gamma crystallin; Region: Crystall; cl02528
378806023756	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
378806023757	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
378806023758	Cysteine-rich domain; Region: CCG; pfam02754
378806023759	Cysteine-rich domain; Region: CCG; pfam02754
378806023760	Replication protein C N-terminal domain; Region: RP-C; pfam03428
378806023761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806023762	non-specific DNA binding site [nucleotide binding]; other site
378806023763	salt bridge; other site
378806023764	sequence-specific DNA binding site [nucleotide binding]; other site
378806023765	RibD C-terminal domain; Region: RibD_C; cl17279
378806023766	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
378806023767	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
378806023768	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
378806023769	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
378806023770	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
378806023771	active site
378806023772	Zn binding site [ion binding]; other site
378806023773	Fic family protein [Function unknown]; Region: COG3177
378806023774	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
378806023775	Fic/DOC family; Region: Fic; pfam02661
378806023776	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
378806023777	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
378806023778	active site
378806023779	metal binding site [ion binding]; metal-binding site
378806023780	Protein kinase domain; Region: Pkinase; pfam00069
378806023781	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023782	active site
378806023783	ATP binding site [chemical binding]; other site
378806023784	substrate binding site [chemical binding]; other site
378806023785	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806023786	substrate binding site [chemical binding]; other site
378806023787	activation loop (A-loop); other site
378806023788	activation loop (A-loop); other site
378806023789	PEGA domain; Region: PEGA; pfam08308
378806023790	Fatty acid desaturase; Region: FA_desaturase; pfam00487
378806023791	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
378806023792	putative di-iron ligands [ion binding]; other site
378806023793	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
378806023794	DNA-binding site [nucleotide binding]; DNA binding site
378806023795	RNA-binding motif; other site
378806023796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806023797	binding surface
378806023798	TPR motif; other site
378806023799	TPR repeat; Region: TPR_11; pfam13414
378806023800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806023801	binding surface
378806023802	TPR motif; other site
378806023803	Uncharacterized conserved protein [Function unknown]; Region: COG3542
378806023804	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806023805	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023806	active site
378806023807	ATP binding site [chemical binding]; other site
378806023808	substrate binding site [chemical binding]; other site
378806023809	activation loop (A-loop); other site
378806023810	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
378806023811	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
378806023812	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
378806023813	non-specific DNA binding site [nucleotide binding]; other site
378806023814	salt bridge; other site
378806023815	sequence-specific DNA binding site [nucleotide binding]; other site
378806023816	putative alpha-glucosidase; Provisional; Region: PRK10658
378806023817	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
378806023818	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
378806023819	trimer interface [polypeptide binding]; other site
378806023820	active site
378806023821	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
378806023822	catalytic site [active]
378806023823	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
378806023824	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
378806023825	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
378806023826	homodimer interface [polypeptide binding]; other site
378806023827	glycosyltransferase, MGT family; Region: MGT; TIGR01426
378806023828	active site
378806023829	TDP-binding site; other site
378806023830	acceptor substrate-binding pocket; other site
378806023831	Histidine kinase; Region: His_kinase; pfam06580
378806023832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023833	ATP binding site [chemical binding]; other site
378806023834	Mg2+ binding site [ion binding]; other site
378806023835	G-X-G motif; other site
378806023836	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
378806023837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
378806023838	active site
378806023839	phosphorylation site [posttranslational modification]
378806023840	intermolecular recognition site; other site
378806023841	dimerization interface [polypeptide binding]; other site
378806023842	LytTr DNA-binding domain; Region: LytTR; smart00850
378806023843	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
378806023844	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806023845	Walker A motif; other site
378806023846	ATP binding site [chemical binding]; other site
378806023847	Walker B motif; other site
378806023848	arginine finger; other site
378806023849	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
378806023850	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806023851	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023852	active site
378806023853	ATP binding site [chemical binding]; other site
378806023854	substrate binding site [chemical binding]; other site
378806023855	activation loop (A-loop); other site
378806023856	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806023857	TPR motif; other site
378806023858	binding surface
378806023859	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
378806023860	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
378806023861	Coenzyme A binding pocket [chemical binding]; other site
378806023862	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806023863	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023864	active site
378806023865	ATP binding site [chemical binding]; other site
378806023866	substrate binding site [chemical binding]; other site
378806023867	activation loop (A-loop); other site
378806023868	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806023869	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
378806023870	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
378806023871	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
378806023872	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
378806023873	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
378806023874	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
378806023875	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
378806023876	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
378806023877	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
378806023878	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
378806023879	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
378806023880	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
378806023881	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
378806023882	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
378806023883	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
378806023884	Walker A/P-loop; other site
378806023885	ATP binding site [chemical binding]; other site
378806023886	Q-loop/lid; other site
378806023887	ABC transporter signature motif; other site
378806023888	Walker B; other site
378806023889	D-loop; other site
378806023890	H-loop/switch region; other site
378806023891	GAF domain; Region: GAF; pfam01590
378806023892	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
378806023893	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
378806023894	putative active site [active]
378806023895	heme pocket [chemical binding]; other site
378806023896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
378806023897	dimer interface [polypeptide binding]; other site
378806023898	phosphorylation site [posttranslational modification]
378806023899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
378806023900	ATP binding site [chemical binding]; other site
378806023901	Mg2+ binding site [ion binding]; other site
378806023902	G-X-G motif; other site
378806023903	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
378806023904	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
378806023905	FAD binding domain; Region: FAD_binding_4; pfam01565
378806023906	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
378806023907	RES domain; Region: RES; pfam08808
378806023908	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
378806023909	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
378806023910	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
378806023911	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
378806023912	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
378806023913	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
378806023914	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
378806023915	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
378806023916	ParB-like nuclease domain; Region: ParB; smart00470
378806023917	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
378806023918	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806023919	P-loop; other site
378806023920	Magnesium ion binding site [ion binding]; other site
378806023921	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
378806023922	Magnesium ion binding site [ion binding]; other site
378806023923	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
378806023924	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
378806023925	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806023926	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023927	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023928	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023929	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806023930	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023931	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023932	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
378806023933	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
378806023934	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
378806023935	GAF domain; Region: GAF; pfam01590
378806023936	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
378806023937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
378806023938	Walker A motif; other site
378806023939	ATP binding site [chemical binding]; other site
378806023940	Walker B motif; other site
378806023941	arginine finger; other site
378806023942	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806023943	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806023944	active site
378806023945	ATP binding site [chemical binding]; other site
378806023946	substrate binding site [chemical binding]; other site
378806023947	activation loop (A-loop); other site
378806023948	AAA ATPase domain; Region: AAA_16; pfam13191
378806023949	PEGA domain; Region: PEGA; pfam08308
378806023950	Uncharacterized conserved protein [Function unknown]; Region: COG1262
378806023951	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
378806023952	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
378806023953	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
378806023954	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
378806023955	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
378806023956	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
378806023957	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
378806023958	Peptidase family S48; Region: Peptidase_S48; cl11616
378806023959	Transcriptional regulators [Transcription]; Region: FadR; COG2186
378806023960	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
378806023961	DNA-binding site [nucleotide binding]; DNA binding site
378806023962	FCD domain; Region: FCD; pfam07729
378806023963	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
378806023964	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
378806023965	TPR motif; other site
378806023966	binding surface
378806023967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
378806023968	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
378806023969	Protein kinase domain; Region: Pkinase; pfam00069
378806023970	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806023971	active site
378806023972	ATP binding site [chemical binding]; other site
378806023973	substrate binding site [chemical binding]; other site
378806023974	activation loop (A-loop); other site
378806023975	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
378806023976	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
378806023977	phosphopeptide binding site; other site
378806023978	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
378806023979	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
378806023980	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
378806023981	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
378806023982	putative dimerization interface [polypeptide binding]; other site
378806023983	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
378806023984	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
378806023985	hydrophobic ligand binding site; other site
378806023986	PBP superfamily domain; Region: PBP_like_2; cl17296
378806023987	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
378806023988	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
378806023989	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
378806023990	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
378806023991	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
378806023992	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
378806023993	Phage Tail Collar Domain; Region: Collar; pfam07484
378806023994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
378806023995	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
378806023996	Moco binding site; other site
378806023997	metal coordination site [ion binding]; other site
378806023998	dimerization interface [polypeptide binding]; other site
378806023999	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
378806024000	Catalytic domain of Protein Kinases; Region: PKc; cd00180
378806024001	active site
378806024002	ATP binding site [chemical binding]; other site
378806024003	substrate binding site [chemical binding]; other site
378806024004	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
378806024005	substrate binding site [chemical binding]; other site
378806024006	activation loop (A-loop); other site
378806024007	activation loop (A-loop); other site
378806024008	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
378806024009	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806024010	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806024011	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806024012	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
378806024013	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
378806024014	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
378806024015	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
378806024016	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
378806024017	oligomer interface [polypeptide binding]; other site
378806024018	tandem repeat interface [polypeptide binding]; other site
378806024019	active site residues [active]
378806024020	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
378806024021	tandem repeat interface [polypeptide binding]; other site
378806024022	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
378806024023	oligomer interface [polypeptide binding]; other site
378806024024	active site residues [active]
378806024025	TadE-like protein; Region: TadE; pfam07811
378806024026	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
378806024027	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
378806024028	putative active site [active]
378806024029	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
378806024030	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
378806024031	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
378806024032	G1 box; other site
378806024033	GTP/Mg2+ binding site [chemical binding]; other site
378806024034	G2 box; other site
378806024035	Switch I region; other site
378806024036	G3 box; other site
378806024037	Switch II region; other site
378806024038	G4 box; other site
378806024039	G5 box; other site
378806024040	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
378806024041	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
378806024042	G-X-X-G motif; other site
378806024043	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
378806024044	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
378806024045	Haemolytic domain; Region: Haemolytic; pfam01809
378806024046	Ribonuclease P; Region: Ribonuclease_P; pfam00825
378806024047	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399