-- dump date 20111121_014923 -- class Genbank::misc_feature -- table misc_feature_note -- id note 378806000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 378806000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806000003 Walker A motif; other site 378806000004 ATP binding site [chemical binding]; other site 378806000005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806000006 Walker B motif; other site 378806000007 arginine finger; other site 378806000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 378806000009 DnaA box-binding interface [nucleotide binding]; other site 378806000010 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806000011 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 378806000012 active site 378806000013 catalytic tetrad [active] 378806000014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806000015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806000016 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 378806000017 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378806000018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000019 active site 378806000020 phosphorylation site [posttranslational modification] 378806000021 intermolecular recognition site; other site 378806000022 dimerization interface [polypeptide binding]; other site 378806000023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806000024 DNA binding site [nucleotide binding] 378806000025 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806000026 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000028 ATP binding site [chemical binding]; other site 378806000029 Mg2+ binding site [ion binding]; other site 378806000030 G-X-G motif; other site 378806000031 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 378806000032 putative active site [active] 378806000033 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 378806000034 FOG: CBS domain [General function prediction only]; Region: COG0517 378806000035 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 378806000036 Secretin and TonB N terminus short domain; Region: STN; pfam07660 378806000037 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 378806000038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000039 binding surface 378806000040 TPR motif; other site 378806000041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000042 binding surface 378806000043 TPR motif; other site 378806000044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000045 binding surface 378806000046 TPR motif; other site 378806000047 CHAT domain; Region: CHAT; cl02083 378806000048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806000049 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 378806000050 putative effector binding pocket; other site 378806000051 putative dimerization interface [polypeptide binding]; other site 378806000052 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806000053 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806000054 active site 378806000055 catalytic tetrad [active] 378806000056 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 378806000057 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 378806000058 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 378806000059 active site 378806000060 nucleophile elbow; other site 378806000061 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806000062 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806000063 active site 378806000064 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806000065 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806000066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806000067 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806000068 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806000069 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 378806000070 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806000071 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806000072 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806000073 Condensation domain; Region: Condensation; cl09290 378806000074 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806000075 peptide synthase; Provisional; Region: PRK12316 378806000076 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 378806000077 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806000078 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806000079 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 378806000080 putative NADP binding site [chemical binding]; other site 378806000081 active site 378806000082 peptide synthase; Provisional; Region: PRK12467 378806000083 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806000084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806000085 S-adenosylmethionine binding site [chemical binding]; other site 378806000086 Cytochrome P450; Region: p450; cl12078 378806000087 Protein kinase; unclassified specificity; Region: STYKc; smart00221 378806000088 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806000089 active site 378806000090 ATP binding site [chemical binding]; other site 378806000091 substrate binding site [chemical binding]; other site 378806000092 activation loop (A-loop); other site 378806000093 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806000094 Predicted ATPase [General function prediction only]; Region: COG3899 378806000095 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806000096 GAF domain; Region: GAF; cl00853 378806000097 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806000098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000099 ATP binding site [chemical binding]; other site 378806000100 Mg2+ binding site [ion binding]; other site 378806000101 G-X-G motif; other site 378806000102 Protein kinase domain; Region: Pkinase; pfam00069 378806000103 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806000104 active site 378806000105 ATP binding site [chemical binding]; other site 378806000106 substrate binding site [chemical binding]; other site 378806000107 activation loop (A-loop); other site 378806000108 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000110 active site 378806000111 phosphorylation site [posttranslational modification] 378806000112 intermolecular recognition site; other site 378806000113 dimerization interface [polypeptide binding]; other site 378806000114 cyclase homology domain; Region: CHD; cd07302 378806000115 nucleotidyl binding site; other site 378806000116 metal binding site [ion binding]; metal-binding site 378806000117 dimer interface [polypeptide binding]; other site 378806000118 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806000119 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806000120 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806000121 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806000122 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806000123 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806000124 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806000125 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806000126 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806000127 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 378806000128 patatin-related protein; Region: TIGR03607 378806000129 active site 378806000130 nucleophile elbow; other site 378806000131 H+ Antiporter protein; Region: 2A0121; TIGR00900 378806000132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806000133 putative substrate translocation pore; other site 378806000134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000135 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000136 active site 378806000137 phosphorylation site [posttranslational modification] 378806000138 intermolecular recognition site; other site 378806000139 dimerization interface [polypeptide binding]; other site 378806000140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806000141 dimer interface [polypeptide binding]; other site 378806000142 phosphorylation site [posttranslational modification] 378806000143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000144 ATP binding site [chemical binding]; other site 378806000145 Mg2+ binding site [ion binding]; other site 378806000146 G-X-G motif; other site 378806000147 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806000148 active site 378806000149 ATP binding site [chemical binding]; other site 378806000150 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806000151 substrate binding site [chemical binding]; other site 378806000152 activation loop (A-loop); other site 378806000153 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 378806000154 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 378806000155 putative heme binding site [chemical binding]; other site 378806000156 putative substrate binding site [chemical binding]; other site 378806000157 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 378806000158 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806000159 active site 378806000160 ATP binding site [chemical binding]; other site 378806000161 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806000162 substrate binding site [chemical binding]; other site 378806000163 activation loop (A-loop); other site 378806000164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000165 TPR motif; other site 378806000166 binding surface 378806000167 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 378806000168 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 378806000169 putative active site [active] 378806000170 putative metal binding site [ion binding]; other site 378806000171 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 378806000172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806000173 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 378806000174 dimerization interface [polypeptide binding]; other site 378806000175 substrate binding pocket [chemical binding]; other site 378806000176 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 378806000177 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 378806000178 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806000179 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 378806000180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 378806000181 PYR/PP interface [polypeptide binding]; other site 378806000182 dimer interface [polypeptide binding]; other site 378806000183 TPP binding site [chemical binding]; other site 378806000184 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 378806000185 TPP-binding site [chemical binding]; other site 378806000186 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 378806000187 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 378806000188 DNA binding residues [nucleotide binding] 378806000189 dimer interface [polypeptide binding]; other site 378806000190 [2Fe-2S] cluster binding site [ion binding]; other site 378806000191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806000192 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 378806000193 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 378806000194 pyridoxal binding site [chemical binding]; other site 378806000195 dimer interface [polypeptide binding]; other site 378806000196 ATP binding site [chemical binding]; other site 378806000197 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 378806000198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806000199 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 378806000200 active site 378806000201 Zn binding site [ion binding]; other site 378806000202 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 378806000203 active site 378806000204 Zn binding site [ion binding]; other site 378806000205 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 378806000206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806000207 glutathione synthetase; Provisional; Region: PRK05246 378806000208 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 378806000209 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806000210 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806000211 Protein kinase domain; Region: Pkinase; pfam00069 378806000212 active site 378806000213 ATP binding site [chemical binding]; other site 378806000214 substrate binding site [chemical binding]; other site 378806000215 activation loop (A-loop); other site 378806000216 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806000217 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806000218 active site 378806000219 catalytic tetrad [active] 378806000220 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 378806000221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806000222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806000223 Proline dehydrogenase; Region: Pro_dh; cl03282 378806000224 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 378806000225 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 378806000226 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806000227 Protein kinase domain; Region: Pkinase; pfam00069 378806000228 active site 378806000229 ATP binding site [chemical binding]; other site 378806000230 substrate binding site [chemical binding]; other site 378806000231 activation loop (A-loop); other site 378806000232 PEGA domain; Region: PEGA; pfam08308 378806000233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806000234 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 378806000235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806000236 dimer interface [polypeptide binding]; other site 378806000237 conserved gate region; other site 378806000238 putative PBP binding loops; other site 378806000239 ABC-ATPase subunit interface; other site 378806000240 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 378806000241 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 378806000242 Walker A/P-loop; other site 378806000243 ATP binding site [chemical binding]; other site 378806000244 Q-loop/lid; other site 378806000245 ABC transporter signature motif; other site 378806000246 Walker B; other site 378806000247 D-loop; other site 378806000248 H-loop/switch region; other site 378806000249 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 378806000250 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 378806000251 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806000252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806000253 DNA-binding site [nucleotide binding]; DNA binding site 378806000254 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806000255 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 378806000256 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806000257 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 378806000258 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 378806000259 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 378806000260 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 378806000261 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 378806000262 Walker A/P-loop; other site 378806000263 ATP binding site [chemical binding]; other site 378806000264 Q-loop/lid; other site 378806000265 ABC transporter signature motif; other site 378806000266 Walker B; other site 378806000267 D-loop; other site 378806000268 H-loop/switch region; other site 378806000269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806000270 dimer interface [polypeptide binding]; other site 378806000271 conserved gate region; other site 378806000272 ABC-ATPase subunit interface; other site 378806000273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806000274 dimer interface [polypeptide binding]; other site 378806000275 conserved gate region; other site 378806000276 putative PBP binding loops; other site 378806000277 ABC-ATPase subunit interface; other site 378806000278 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 378806000279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806000280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806000281 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 378806000282 Walker A motif; other site 378806000283 ATP binding site [chemical binding]; other site 378806000284 Walker B motif; other site 378806000285 arginine finger; other site 378806000286 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 378806000287 Glucose dehydrogenase; Region: glucose_DH; cd08230 378806000288 NADP binding site [chemical binding]; other site 378806000289 catalytic Zn binding site [ion binding]; other site 378806000290 structural Zn binding site [ion binding]; other site 378806000291 dimer interface [polypeptide binding]; other site 378806000292 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806000293 GAF domain; Region: GAF; cl00853 378806000294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806000295 PAS fold; Region: PAS_3; pfam08447 378806000296 putative active site [active] 378806000297 heme pocket [chemical binding]; other site 378806000298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806000299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806000300 dimer interface [polypeptide binding]; other site 378806000301 phosphorylation site [posttranslational modification] 378806000302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000303 ATP binding site [chemical binding]; other site 378806000304 Mg2+ binding site [ion binding]; other site 378806000305 G-X-G motif; other site 378806000306 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000308 active site 378806000309 phosphorylation site [posttranslational modification] 378806000310 intermolecular recognition site; other site 378806000311 dimerization interface [polypeptide binding]; other site 378806000312 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl02012 378806000313 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806000314 Cupin domain; Region: Cupin_2; cl09118 378806000315 PilZ domain; Region: PilZ; cl01260 378806000316 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 378806000317 hypothetical protein; Reviewed; Region: PRK09588 378806000318 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 378806000319 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 378806000320 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 378806000321 putative NAD(P) binding site [chemical binding]; other site 378806000322 putative substrate binding site [chemical binding]; other site 378806000323 catalytic Zn binding site [ion binding]; other site 378806000324 structural Zn binding site [ion binding]; other site 378806000325 dimer interface [polypeptide binding]; other site 378806000326 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 378806000327 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 378806000328 putative active site [active] 378806000329 catalytic site [active] 378806000330 putative metal binding site [ion binding]; other site 378806000331 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 378806000332 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 378806000333 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806000334 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 378806000335 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 378806000336 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 378806000337 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806000338 active site 378806000339 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806000340 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238 378806000341 PA/protease or protease-like domain interface [polypeptide binding]; other site 378806000342 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 378806000343 metal binding site [ion binding]; metal-binding site 378806000344 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 378806000345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806000346 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 378806000347 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806000348 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 378806000349 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806000350 tetrameric interface [polypeptide binding]; other site 378806000351 NAD binding site [chemical binding]; other site 378806000352 catalytic residues [active] 378806000353 hypothetical protein; Validated; Region: PRK07198 378806000354 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 378806000355 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 378806000356 dimerization interface [polypeptide binding]; other site 378806000357 active site 378806000358 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 378806000359 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806000360 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 378806000361 active site flap/lid [active] 378806000362 nucleophilic elbow; other site 378806000363 catalytic triad [active] 378806000364 potential frameshift: common BLAST hit: gi|251799209|ref|YP_003013940.1| coagulation factor 5/8 type domain protein 378806000365 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 378806000366 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 378806000367 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 378806000368 putative active site [active] 378806000369 putative metal binding site [ion binding]; other site 378806000370 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 378806000371 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806000372 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 378806000373 active site 378806000374 8-oxo-dGMP binding site [chemical binding]; other site 378806000375 nudix motif; other site 378806000376 metal binding site [ion binding]; metal-binding site 378806000377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806000378 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 378806000379 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 378806000380 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 378806000381 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 378806000382 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 378806000383 Penicillin amidase; Region: Penicil_amidase; pfam01804 378806000384 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 378806000385 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_CA; cd01936 378806000386 active site 378806000387 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 378806000388 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 378806000389 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 378806000390 Cl- selectivity filter; other site 378806000391 Cl- binding residues [ion binding]; other site 378806000392 pore gating glutamate residue; other site 378806000393 dimer interface [polypeptide binding]; other site 378806000394 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 378806000395 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 378806000396 putative active site [active] 378806000397 putative NTP binding site [chemical binding]; other site 378806000398 putative nucleic acid binding site [nucleotide binding]; other site 378806000399 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806000400 structural tetrad; other site 378806000401 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 378806000402 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806000403 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 378806000404 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 378806000405 Predicted ATPase [General function prediction only]; Region: COG3899 378806000406 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806000407 active site 378806000408 ATP binding site [chemical binding]; other site 378806000409 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806000410 substrate binding site [chemical binding]; other site 378806000411 activation loop (A-loop); other site 378806000412 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 378806000413 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 378806000414 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 378806000415 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 378806000416 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806000417 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 378806000418 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806000419 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806000420 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 378806000421 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 378806000422 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 378806000423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806000424 motif II; other site 378806000425 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 378806000426 ligand binding site [chemical binding]; other site 378806000427 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806000428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806000429 DNA-binding site [nucleotide binding]; DNA binding site 378806000430 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 378806000431 acetoin reductases; Region: 23BDH; TIGR02415 378806000432 NADP binding site [chemical binding]; other site 378806000433 active site 378806000434 steroid binding site; other site 378806000435 Cupin domain; Region: Cupin_2; cl09118 378806000436 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 378806000437 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806000438 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_2; cd04821 378806000439 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 378806000440 PA/protease or protease-like domain interface [polypeptide binding]; other site 378806000441 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 378806000442 metal binding site [ion binding]; metal-binding site 378806000443 Protein of unknown function (DUF808); Region: DUF808; cl01002 378806000444 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 378806000445 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 378806000446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806000447 putative substrate translocation pore; other site 378806000448 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 378806000449 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 378806000450 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806000451 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 378806000452 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 378806000453 Walker A/P-loop; other site 378806000454 ATP binding site [chemical binding]; other site 378806000455 Q-loop/lid; other site 378806000456 ABC transporter signature motif; other site 378806000457 Walker B; other site 378806000458 D-loop; other site 378806000459 H-loop/switch region; other site 378806000460 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 378806000461 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 378806000462 TM-ABC transporter signature motif; other site 378806000463 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 378806000464 putative ligand binding site [chemical binding]; other site 378806000465 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 378806000466 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 378806000467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378806000468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806000469 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 378806000470 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806000471 structural tetrad; other site 378806000472 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806000473 structural tetrad; other site 378806000474 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806000475 structural tetrad; other site 378806000476 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806000477 structural tetrad; other site 378806000478 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806000479 structural tetrad; other site 378806000480 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806000481 structural tetrad; other site 378806000482 FOG: WD40 repeat [General function prediction only]; Region: COG2319 378806000483 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806000484 structural tetrad; other site 378806000485 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806000486 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806000487 active site 378806000488 metal binding site [ion binding]; metal-binding site 378806000489 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 378806000490 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378806000491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806000492 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 378806000493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806000494 S-adenosylmethionine binding site [chemical binding]; other site 378806000495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806000496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000497 ATP binding site [chemical binding]; other site 378806000498 Mg2+ binding site [ion binding]; other site 378806000499 G-X-G motif; other site 378806000500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806000501 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806000502 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 378806000503 Fic family protein [Function unknown]; Region: COG3177 378806000504 Fic/DOC family; Region: Fic; cl00960 378806000505 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 378806000506 active site 378806000507 phosphorylation site [posttranslational modification] 378806000508 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 378806000509 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 378806000510 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 378806000511 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 378806000512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806000513 K+-transporting ATPase, c chain; Region: KdpC; cl00944 378806000514 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 378806000515 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 378806000516 Ligand Binding Site [chemical binding]; other site 378806000517 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 378806000518 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806000519 dimerization interface [polypeptide binding]; other site 378806000520 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806000521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806000522 dimer interface [polypeptide binding]; other site 378806000523 phosphorylation site [posttranslational modification] 378806000524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000525 ATP binding site [chemical binding]; other site 378806000526 Mg2+ binding site [ion binding]; other site 378806000527 G-X-G motif; other site 378806000528 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806000529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000530 active site 378806000531 phosphorylation site [posttranslational modification] 378806000532 intermolecular recognition site; other site 378806000533 dimerization interface [polypeptide binding]; other site 378806000534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806000535 Walker A motif; other site 378806000536 ATP binding site [chemical binding]; other site 378806000537 Walker B motif; other site 378806000538 arginine finger; other site 378806000539 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806000540 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806000541 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806000542 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806000543 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 378806000544 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 378806000545 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 378806000546 active site 378806000547 zinc binding site [ion binding]; other site 378806000548 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806000549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806000550 DNA-binding site [nucleotide binding]; DNA binding site 378806000551 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 378806000552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806000553 Coenzyme A binding pocket [chemical binding]; other site 378806000554 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 378806000555 active site 378806000556 catalytic triad [active] 378806000557 oxyanion hole [active] 378806000558 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 378806000559 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 378806000560 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 378806000561 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 378806000562 cofactor binding site; other site 378806000563 DNA binding site [nucleotide binding] 378806000564 substrate interaction site [chemical binding]; other site 378806000565 potential frameshift: common BLAST hit: gi|108758771|ref|YP_628458.1| formate--tetrahydrofolate ligase 378806000566 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806000567 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 378806000568 Potassium binding sites [ion binding]; other site 378806000569 Cesium cation binding sites [ion binding]; other site 378806000570 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 378806000571 Erythromycin esterase; Region: Erythro_esteras; pfam05139 378806000572 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806000573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806000574 AsmA family; Region: AsmA; pfam05170 378806000575 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 378806000576 AsmA family; Region: AsmA; pfam05170 378806000577 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000578 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000579 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000580 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000581 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000582 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000583 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000584 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000585 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000586 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000587 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 378806000588 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000589 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806000590 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 378806000591 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 378806000592 CHAT domain; Region: CHAT; cl02083 378806000593 Domain of unknown function DUF11; Region: DUF11; cl03172 378806000594 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806000595 ligand binding site [chemical binding]; other site 378806000596 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 378806000597 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 378806000598 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 378806000599 putative NAD(P) binding site [chemical binding]; other site 378806000600 hypothetical protein; Provisional; Region: PRK06834 378806000601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806000602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806000603 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806000604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806000605 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 378806000606 Cytochrome P450; Region: p450; cl12078 378806000607 Cytochrome P450; Region: p450; cl12078 378806000608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000609 binding surface 378806000610 TPR motif; other site 378806000611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000612 binding surface 378806000613 TPR motif; other site 378806000614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000615 binding surface 378806000616 TPR motif; other site 378806000617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000618 binding surface 378806000619 TPR motif; other site 378806000620 CHAT domain; Region: CHAT; cl02083 378806000621 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806000622 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 378806000623 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 378806000624 substrate binding [chemical binding]; other site 378806000625 active site 378806000626 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 378806000627 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 378806000628 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806000629 Protein kinase domain; Region: Pkinase; pfam00069 378806000630 active site 378806000631 ATP binding site [chemical binding]; other site 378806000632 substrate binding site [chemical binding]; other site 378806000633 activation loop (A-loop); other site 378806000634 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 378806000635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000636 binding surface 378806000637 TPR motif; other site 378806000638 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806000639 metal ion-dependent adhesion site (MIDAS); other site 378806000640 PAS domain S-box; Region: sensory_box; TIGR00229 378806000641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806000642 putative active site [active] 378806000643 heme pocket [chemical binding]; other site 378806000644 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806000645 GAF domain; Region: GAF; cl00853 378806000646 PAS fold; Region: PAS_3; pfam08447 378806000647 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 378806000648 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806000649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806000650 dimer interface [polypeptide binding]; other site 378806000651 phosphorylation site [posttranslational modification] 378806000652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000653 ATP binding site [chemical binding]; other site 378806000654 Mg2+ binding site [ion binding]; other site 378806000655 G-X-G motif; other site 378806000656 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000658 active site 378806000659 phosphorylation site [posttranslational modification] 378806000660 intermolecular recognition site; other site 378806000661 dimerization interface [polypeptide binding]; other site 378806000662 GAF domain; Region: GAF; cl00853 378806000663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806000664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000665 ATP binding site [chemical binding]; other site 378806000666 Mg2+ binding site [ion binding]; other site 378806000667 G-X-G motif; other site 378806000668 C-term; Region: GreA_GreB; pfam01272 378806000669 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 378806000670 active site residue [active] 378806000671 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 378806000672 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 378806000673 active site 378806000674 catalytic residues [active] 378806000675 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 378806000676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806000677 NAD(P) binding site [chemical binding]; other site 378806000678 active site 378806000679 Beta-lactamase; Region: Beta-lactamase; cl01009 378806000680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806000681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806000682 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 378806000683 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 378806000684 dimer interface [polypeptide binding]; other site 378806000685 active site 378806000686 CoA binding pocket [chemical binding]; other site 378806000687 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806000688 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 378806000689 hypothetical protein; Region: PHA01818 378806000690 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806000691 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806000692 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806000693 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 378806000694 Cache domain; Region: Cache_2; pfam08269 378806000695 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806000696 dimerization interface [polypeptide binding]; other site 378806000697 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806000698 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806000699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 378806000700 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000702 active site 378806000703 phosphorylation site [posttranslational modification] 378806000704 intermolecular recognition site; other site 378806000705 dimerization interface [polypeptide binding]; other site 378806000706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806000707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806000708 dimer interface [polypeptide binding]; other site 378806000709 phosphorylation site [posttranslational modification] 378806000710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000711 ATP binding site [chemical binding]; other site 378806000712 Mg2+ binding site [ion binding]; other site 378806000713 G-X-G motif; other site 378806000714 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000716 active site 378806000717 phosphorylation site [posttranslational modification] 378806000718 intermolecular recognition site; other site 378806000719 dimerization interface [polypeptide binding]; other site 378806000720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806000721 dimer interface [polypeptide binding]; other site 378806000722 phosphorylation site [posttranslational modification] 378806000723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000724 ATP binding site [chemical binding]; other site 378806000725 Mg2+ binding site [ion binding]; other site 378806000726 G-X-G motif; other site 378806000727 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000729 active site 378806000730 phosphorylation site [posttranslational modification] 378806000731 intermolecular recognition site; other site 378806000732 dimerization interface [polypeptide binding]; other site 378806000733 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806000734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000735 active site 378806000736 phosphorylation site [posttranslational modification] 378806000737 intermolecular recognition site; other site 378806000738 dimerization interface [polypeptide binding]; other site 378806000739 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 378806000740 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 378806000741 B12 binding site [chemical binding]; other site 378806000742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806000743 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 378806000744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000745 ATP binding site [chemical binding]; other site 378806000746 Mg2+ binding site [ion binding]; other site 378806000747 G-X-G motif; other site 378806000748 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 378806000749 anchoring element; other site 378806000750 dimer interface [polypeptide binding]; other site 378806000751 ATP binding site [chemical binding]; other site 378806000752 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 378806000753 active site 378806000754 putative metal-binding site [ion binding]; other site 378806000755 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 378806000756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806000757 Walker A/P-loop; other site 378806000758 ATP binding site [chemical binding]; other site 378806000759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806000760 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 378806000761 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806000762 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 378806000763 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 378806000764 dimer interface [polypeptide binding]; other site 378806000765 putative functional site; other site 378806000766 putative MPT binding site; other site 378806000767 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 378806000768 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 378806000769 GTP binding site [chemical binding]; other site 378806000770 PAS fold; Region: PAS_4; pfam08448 378806000771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 378806000772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806000773 dimer interface [polypeptide binding]; other site 378806000774 phosphorylation site [posttranslational modification] 378806000775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000776 ATP binding site [chemical binding]; other site 378806000777 Mg2+ binding site [ion binding]; other site 378806000778 G-X-G motif; other site 378806000779 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000781 active site 378806000782 phosphorylation site [posttranslational modification] 378806000783 intermolecular recognition site; other site 378806000784 dimerization interface [polypeptide binding]; other site 378806000785 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806000786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806000787 Walker A motif; other site 378806000788 ATP binding site [chemical binding]; other site 378806000789 Walker B motif; other site 378806000790 arginine finger; other site 378806000791 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806000792 active site 378806000793 ATP binding site [chemical binding]; other site 378806000794 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806000795 substrate binding site [chemical binding]; other site 378806000796 activation loop (A-loop); other site 378806000797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000798 TPR motif; other site 378806000799 binding surface 378806000800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806000801 TPR motif; other site 378806000802 binding surface 378806000803 Proline dehydrogenase; Region: Pro_dh; cl03282 378806000804 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806000805 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 378806000806 putative acyl-acceptor binding pocket; other site 378806000807 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 378806000808 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806000809 ligand binding site [chemical binding]; other site 378806000810 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806000811 ligand binding site [chemical binding]; other site 378806000812 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 378806000813 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 378806000814 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000816 active site 378806000817 phosphorylation site [posttranslational modification] 378806000818 intermolecular recognition site; other site 378806000819 dimerization interface [polypeptide binding]; other site 378806000820 cyclase homology domain; Region: CHD; cd07302 378806000821 nucleotidyl binding site; other site 378806000822 metal binding site [ion binding]; metal-binding site 378806000823 dimer interface [polypeptide binding]; other site 378806000824 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 378806000825 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806000826 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 378806000827 putative ADP-ribose binding site [chemical binding]; other site 378806000828 putative active site [active] 378806000829 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 378806000830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806000831 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806000832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806000833 catalytic residue [active] 378806000834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806000835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806000836 homodimer interface [polypeptide binding]; other site 378806000837 catalytic residue [active] 378806000838 Cupin domain; Region: Cupin_2; cl09118 378806000839 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 378806000840 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 378806000841 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 378806000842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806000843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806000844 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806000845 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 378806000846 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000847 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000848 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806000849 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 378806000850 large tegument protein UL36; Provisional; Region: PHA03247 378806000851 Transposase domain (DUF772); Region: DUF772; cl12084 378806000852 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806000853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806000854 DNA-binding site [nucleotide binding]; DNA binding site 378806000855 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 378806000856 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806000857 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806000858 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 378806000859 Cu(I) binding site [ion binding]; other site 378806000860 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 378806000861 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 378806000862 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 378806000863 D-pathway; other site 378806000864 Low-spin heme binding site [chemical binding]; other site 378806000865 Putative water exit pathway; other site 378806000866 Binuclear center (active site) [active] 378806000867 K-pathway; other site 378806000868 Putative proton exit pathway; other site 378806000869 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806000870 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806000871 catalytic residue [active] 378806000872 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 378806000873 Protein kinase domain; Region: Pkinase; pfam00069 378806000874 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806000875 active site 378806000876 ATP binding site [chemical binding]; other site 378806000877 substrate binding site [chemical binding]; other site 378806000878 activation loop (A-loop); other site 378806000879 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 378806000880 putative hydrophobic ligand binding site [chemical binding]; other site 378806000881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378806000882 dimerization interface [polypeptide binding]; other site 378806000883 putative DNA binding site [nucleotide binding]; other site 378806000884 putative Zn2+ binding site [ion binding]; other site 378806000885 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 378806000886 dimer interface [polypeptide binding]; other site 378806000887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806000888 S-adenosylmethionine binding site [chemical binding]; other site 378806000889 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806000890 putative metal binding site [ion binding]; other site 378806000891 Domain of unknown function (DU1801); Region: DUF1801; cl01838 378806000892 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 378806000893 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 378806000894 substrate binding pocket [chemical binding]; other site 378806000895 membrane-bound complex binding site; other site 378806000896 hinge residues; other site 378806000897 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 378806000898 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 378806000899 Chromate transporter; Region: Chromate_transp; pfam02417 378806000900 Chromate transporter; Region: Chromate_transp; pfam02417 378806000901 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 378806000902 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806000903 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 378806000904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806000905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806000906 conserved gate region; other site 378806000907 putative PBP binding loops; other site 378806000908 ABC-ATPase subunit interface; other site 378806000909 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 378806000910 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 378806000911 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 378806000912 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 378806000913 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 378806000914 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 378806000915 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 378806000916 active site 378806000917 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 378806000918 dimer interface [polypeptide binding]; other site 378806000919 active site 378806000920 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 378806000921 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806000922 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806000923 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806000924 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 378806000925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806000926 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806000927 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 378806000928 Beta/Gamma crystallin; Region: Crystall; cl02528 378806000929 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 378806000930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806000931 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 378806000932 thioester formation/cholesterol transfer; other site 378806000933 protein-splicing catalytic site; other site 378806000934 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 378806000935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806000936 PAS fold; Region: PAS_4; pfam08448 378806000937 GAF domain; Region: GAF; cl00853 378806000938 PAS fold; Region: PAS_4; pfam08448 378806000939 PAS domain S-box; Region: sensory_box; TIGR00229 378806000940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806000941 putative active site [active] 378806000942 heme pocket [chemical binding]; other site 378806000943 GAF domain; Region: GAF; cl00853 378806000944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806000945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806000946 dimer interface [polypeptide binding]; other site 378806000947 phosphorylation site [posttranslational modification] 378806000948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806000949 ATP binding site [chemical binding]; other site 378806000950 Mg2+ binding site [ion binding]; other site 378806000951 G-X-G motif; other site 378806000952 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000954 active site 378806000955 phosphorylation site [posttranslational modification] 378806000956 intermolecular recognition site; other site 378806000957 dimerization interface [polypeptide binding]; other site 378806000958 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 378806000959 active site 378806000960 catalytic site [active] 378806000961 substrate binding site [chemical binding]; other site 378806000962 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic (...; Region: POLBc; cl10023 378806000963 active site 378806000964 metal-binding site 378806000965 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806000966 putative peptidoglycan binding site; other site 378806000967 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378806000968 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 378806000969 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806000970 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 378806000971 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 378806000972 dimer interface [polypeptide binding]; other site 378806000973 substrate binding site [chemical binding]; other site 378806000974 ATP binding site [chemical binding]; other site 378806000975 FOG: CBS domain [General function prediction only]; Region: COG0517 378806000976 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 378806000977 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806000978 Metal binding site [ion binding]; metal-binding site 378806000979 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806000980 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806000981 ATP binding site [chemical binding]; other site 378806000982 dimerization interface [polypeptide binding]; other site 378806000983 Metal binding site [ion binding]; metal-binding site 378806000984 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 378806000985 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 378806000986 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806000987 Cytochrome P450; Region: p450; cl12078 378806000988 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 378806000989 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000991 active site 378806000992 phosphorylation site [posttranslational modification] 378806000993 intermolecular recognition site; other site 378806000994 dimerization interface [polypeptide binding]; other site 378806000995 Response regulator receiver domain; Region: Response_reg; pfam00072 378806000996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806000997 active site 378806000998 phosphorylation site [posttranslational modification] 378806000999 intermolecular recognition site; other site 378806001000 dimerization interface [polypeptide binding]; other site 378806001001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806001002 Coenzyme A binding pocket [chemical binding]; other site 378806001003 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 378806001004 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 378806001005 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 378806001006 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 378806001007 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 378806001008 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 378806001009 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 378806001010 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 378806001011 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 378806001012 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 378806001013 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 378806001014 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 378806001015 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 378806001016 putative heme binding pocket [chemical binding]; other site 378806001017 OsmC-like protein; Region: OsmC; cl00767 378806001018 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378806001019 catalytic core [active] 378806001020 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 378806001021 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 378806001022 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 378806001023 Zn binding site [ion binding]; other site 378806001024 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806001025 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806001026 active site 378806001027 catalytic tetrad [active] 378806001028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806001029 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806001030 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_1; cd04820 378806001031 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 378806001032 PA/protease or protease-like domain interface [polypeptide binding]; other site 378806001033 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 378806001034 metal binding site [ion binding]; metal-binding site 378806001035 SOUL heme-binding protein; Region: SOUL; pfam04832 378806001036 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806001037 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 378806001038 putative metal binding site [ion binding]; other site 378806001039 CARDB; Region: CARDB; pfam07705 378806001040 CARDB; Region: CARDB; pfam07705 378806001041 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 378806001042 putative metal binding site [ion binding]; other site 378806001043 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 378806001044 Predicted ATPase [General function prediction only]; Region: COG4637 378806001045 transketolase; Reviewed; Region: PRK05899 378806001046 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 378806001047 TPP-binding site [chemical binding]; other site 378806001048 dimer interface [polypeptide binding]; other site 378806001049 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 378806001050 PYR/PP interface [polypeptide binding]; other site 378806001051 dimer interface [polypeptide binding]; other site 378806001052 TPP binding site [chemical binding]; other site 378806001053 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 378806001054 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 378806001055 Beta-lactamase; Region: Beta-lactamase; cl01009 378806001056 PilZ domain; Region: PilZ; cl01260 378806001057 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806001058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806001059 Walker A motif; other site 378806001060 ATP binding site [chemical binding]; other site 378806001061 Walker B motif; other site 378806001062 arginine finger; other site 378806001063 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806001064 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806001065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001066 active site 378806001067 phosphorylation site [posttranslational modification] 378806001068 intermolecular recognition site; other site 378806001069 dimerization interface [polypeptide binding]; other site 378806001070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001071 active site 378806001072 phosphorylation site [posttranslational modification] 378806001073 intermolecular recognition site; other site 378806001074 dimerization interface [polypeptide binding]; other site 378806001075 PAS domain S-box; Region: sensory_box; TIGR00229 378806001076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806001077 putative active site [active] 378806001078 heme pocket [chemical binding]; other site 378806001079 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806001080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001081 ATP binding site [chemical binding]; other site 378806001082 Mg2+ binding site [ion binding]; other site 378806001083 G-X-G motif; other site 378806001084 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001086 active site 378806001087 phosphorylation site [posttranslational modification] 378806001088 intermolecular recognition site; other site 378806001089 dimerization interface [polypeptide binding]; other site 378806001090 CARDB; Region: CARDB; pfam07705 378806001091 Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080 378806001092 putative catalytic site [active] 378806001093 putative metal binding site [ion binding]; other site 378806001094 putative phosphate binding site [ion binding]; other site 378806001095 hypothetical protein; Provisional; Region: PRK13679 378806001096 Poly(A) polymerase central domain; Region: PAP_central; pfam04928 378806001097 Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402 378806001098 active site 378806001099 putative primer-binding pocket; other site 378806001100 metal binding triad [ion binding]; metal-binding site 378806001101 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 378806001102 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806001103 Protein kinase domain; Region: Pkinase; pfam00069 378806001104 active site 378806001105 ATP binding site [chemical binding]; other site 378806001106 substrate binding site [chemical binding]; other site 378806001107 activation loop (A-loop); other site 378806001108 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 378806001109 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 378806001110 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 378806001111 Cu(I) binding site [ion binding]; other site 378806001112 Protein of unknown function (DUF461); Region: DUF461; cl01071 378806001113 Cytochrome c; Region: Cytochrom_C; cl11414 378806001114 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001116 active site 378806001117 phosphorylation site [posttranslational modification] 378806001118 intermolecular recognition site; other site 378806001119 dimerization interface [polypeptide binding]; other site 378806001120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001121 active site 378806001122 phosphorylation site [posttranslational modification] 378806001123 intermolecular recognition site; other site 378806001124 dimerization interface [polypeptide binding]; other site 378806001125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806001126 PAS fold; Region: PAS_3; pfam08447 378806001127 putative active site [active] 378806001128 heme pocket [chemical binding]; other site 378806001129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806001130 dimer interface [polypeptide binding]; other site 378806001131 phosphorylation site [posttranslational modification] 378806001132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001133 ATP binding site [chemical binding]; other site 378806001134 G-X-G motif; other site 378806001135 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 378806001136 active site 378806001137 catalytic residues [active] 378806001138 metal binding site [ion binding]; metal-binding site 378806001139 SlyX; Region: SlyX; cl01090 378806001140 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806001141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806001142 binding surface 378806001143 TPR motif; other site 378806001144 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 378806001145 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806001146 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806001147 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 378806001148 active site 378806001149 catalytic residues [active] 378806001150 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cd00538 378806001151 PA/protease or protease-like domain interface [polypeptide binding]; other site 378806001152 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 378806001153 catalytic residues [active] 378806001154 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806001155 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806001156 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 378806001157 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806001158 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 378806001159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806001160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806001161 TPR motif; other site 378806001162 binding surface 378806001163 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806001164 CHASE3 domain; Region: CHASE3; cl05000 378806001165 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806001166 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 378806001167 putative binding surface; other site 378806001168 active site 378806001169 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 378806001170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806001171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001172 active site 378806001173 phosphorylation site [posttranslational modification] 378806001174 intermolecular recognition site; other site 378806001175 dimerization interface [polypeptide binding]; other site 378806001176 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 378806001177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001178 active site 378806001179 phosphorylation site [posttranslational modification] 378806001180 intermolecular recognition site; other site 378806001181 dimerization interface [polypeptide binding]; other site 378806001182 CheB methylesterase; Region: CheB_methylest; pfam01339 378806001183 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001185 active site 378806001186 phosphorylation site [posttranslational modification] 378806001187 intermolecular recognition site; other site 378806001188 dimerization interface [polypeptide binding]; other site 378806001189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001190 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001191 active site 378806001192 phosphorylation site [posttranslational modification] 378806001193 intermolecular recognition site; other site 378806001194 dimerization interface [polypeptide binding]; other site 378806001195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806001196 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806001197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806001198 dimer interface [polypeptide binding]; other site 378806001199 phosphorylation site [posttranslational modification] 378806001200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001201 ATP binding site [chemical binding]; other site 378806001202 Mg2+ binding site [ion binding]; other site 378806001203 G-X-G motif; other site 378806001204 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001206 active site 378806001207 phosphorylation site [posttranslational modification] 378806001208 intermolecular recognition site; other site 378806001209 dimerization interface [polypeptide binding]; other site 378806001210 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 378806001211 cleavage site 378806001212 active site 378806001213 substrate binding sites [chemical binding]; other site 378806001214 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806001215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 378806001216 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 378806001217 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806001218 active site 378806001219 ATP binding site [chemical binding]; other site 378806001220 GAF domain; Region: GAF; cl00853 378806001221 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 378806001222 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806001223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806001224 dimer interface [polypeptide binding]; other site 378806001225 phosphorylation site [posttranslational modification] 378806001226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001227 ATP binding site [chemical binding]; other site 378806001228 Mg2+ binding site [ion binding]; other site 378806001229 G-X-G motif; other site 378806001230 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806001231 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 378806001232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806001233 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 378806001234 HipA-like N-terminal domain; Region: HipA_N; pfam07805 378806001235 HipA-like C-terminal domain; Region: HipA_C; pfam07804 378806001236 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 378806001237 EVE domain; Region: EVE; cl00728 378806001238 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 378806001239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806001240 Walker A motif; other site 378806001241 ATP binding site [chemical binding]; other site 378806001242 Walker B motif; other site 378806001243 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 378806001244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806001245 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378806001246 putative substrate translocation pore; other site 378806001247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806001248 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 378806001249 kelch-like protein; Provisional; Region: PHA03098 378806001250 Kelch motif; Region: Kelch_1; cl02701 378806001251 Kelch motif; Region: Kelch_1; cl02701 378806001252 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 378806001253 active site 378806001254 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001256 active site 378806001257 phosphorylation site [posttranslational modification] 378806001258 intermolecular recognition site; other site 378806001259 dimerization interface [polypeptide binding]; other site 378806001260 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 378806001261 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001262 Walker A motif; other site 378806001263 ATP binding site [chemical binding]; other site 378806001264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001265 Walker A motif; other site 378806001266 ATP binding site [chemical binding]; other site 378806001267 Walker B motif; other site 378806001268 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 378806001269 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 378806001270 homodimer interface [polypeptide binding]; other site 378806001271 substrate-cofactor binding pocket; other site 378806001272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806001273 catalytic residue [active] 378806001274 Predicted peptidase [General function prediction only]; Region: COG4099 378806001275 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806001276 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 378806001277 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806001278 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806001279 putative sugar binding sites [chemical binding]; other site 378806001280 Q-X-W motif; other site 378806001281 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 378806001282 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 378806001283 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 378806001284 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 378806001285 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 378806001286 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 378806001287 conserved cys residue [active] 378806001288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806001289 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 378806001290 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806001291 putative sugar binding sites [chemical binding]; other site 378806001292 Q-X-W motif; other site 378806001293 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 378806001294 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806001295 CARDB; Region: CARDB; pfam07705 378806001296 CARDB; Region: CARDB; pfam07705 378806001297 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 378806001298 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806001299 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 378806001300 UreF; Region: UreF; pfam01730 378806001301 urease subunit alpha; Reviewed; Region: ureC; PRK13207 378806001302 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 378806001303 subunit interactions [polypeptide binding]; other site 378806001304 active site 378806001305 flap region; other site 378806001306 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 378806001307 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 378806001308 alpha-gamma subunit interface [polypeptide binding]; other site 378806001309 beta-gamma subunit interface [polypeptide binding]; other site 378806001310 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 378806001311 gamma-beta subunit interface [polypeptide binding]; other site 378806001312 alpha-beta subunit interface [polypeptide binding]; other site 378806001313 UreD urease accessory protein; Region: UreD; cl00530 378806001314 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 378806001315 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806001316 active site 378806001317 HIGH motif; other site 378806001318 nucleotide binding site [chemical binding]; other site 378806001319 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 378806001320 active site 378806001321 KMSKS motif; other site 378806001322 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 378806001323 tRNA binding surface [nucleotide binding]; other site 378806001324 anticodon binding site; other site 378806001325 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 378806001326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806001327 putative substrate translocation pore; other site 378806001328 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 378806001329 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 378806001330 Cytochrome P450; Region: p450; cl12078 378806001331 Cupin superfamily protein; Region: Cupin_4; pfam08007 378806001332 JmjC domain; Region: JmjC; pfam02373 378806001333 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 378806001334 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 378806001335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806001336 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 378806001337 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 378806001338 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 378806001339 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806001340 catalytic residue [active] 378806001341 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806001342 Peptidase C26; Region: Peptidase_C26; pfam07722 378806001343 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 378806001344 catalytic triad [active] 378806001345 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 378806001346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806001347 FeS/SAM binding site; other site 378806001348 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806001349 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 378806001350 Radical SAM; Region: Elp3; smart00729 378806001351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806001352 FeS/SAM binding site; other site 378806001353 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 378806001354 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 378806001355 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 378806001356 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806001357 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 378806001358 active site 378806001359 catalytic triad [active] 378806001360 oxyanion hole [active] 378806001361 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 378806001362 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806001363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806001364 active site 378806001365 catalytic tetrad [active] 378806001366 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 378806001367 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 378806001368 catalytic residues [active] 378806001369 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 378806001370 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 378806001371 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 378806001372 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 378806001373 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 378806001374 active site 378806001375 catalytic residues [active] 378806001376 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cd00538 378806001377 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 378806001378 catalytic residues [active] 378806001379 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 378806001380 Protein kinase domain; Region: Pkinase; pfam00069 378806001381 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806001382 active site 378806001383 ATP binding site [chemical binding]; other site 378806001384 substrate binding site [chemical binding]; other site 378806001385 activation loop (A-loop); other site 378806001386 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 378806001387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001388 active site 378806001389 phosphorylation site [posttranslational modification] 378806001390 intermolecular recognition site; other site 378806001391 dimerization interface [polypeptide binding]; other site 378806001392 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806001393 phosphopeptide binding site; other site 378806001394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806001395 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 378806001396 Walker A motif; other site 378806001397 ATP binding site [chemical binding]; other site 378806001398 Walker B motif; other site 378806001399 arginine finger; other site 378806001400 Protein of unknown function (DUF541); Region: SIMPL; cl01077 378806001401 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806001402 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806001403 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 378806001404 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 378806001405 PEGA domain; Region: PEGA; pfam08308 378806001406 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 378806001407 nudix motif; other site 378806001408 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 378806001409 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 378806001410 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 378806001411 catalytic triad [active] 378806001412 conserved cis-peptide bond; other site 378806001413 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806001414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806001415 dimer interface [polypeptide binding]; other site 378806001416 phosphorylation site [posttranslational modification] 378806001417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001418 ATP binding site [chemical binding]; other site 378806001419 Mg2+ binding site [ion binding]; other site 378806001420 G-X-G motif; other site 378806001421 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 378806001422 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 378806001423 active site 378806001424 thioredoxin 2; Provisional; Region: PRK10996 378806001425 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 378806001426 catalytic residues [active] 378806001427 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 378806001428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378806001429 RNA binding surface [nucleotide binding]; other site 378806001430 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806001431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806001432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806001433 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 378806001434 DNA polymerase III subunit beta; Validated; Region: PRK05643 378806001435 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 378806001436 putative DNA binding surface [nucleotide binding]; other site 378806001437 dimer interface [polypeptide binding]; other site 378806001438 beta-clamp/clamp loader binding surface; other site 378806001439 beta-clamp/translesion DNA polymerase binding surface; other site 378806001440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 378806001441 recombination protein F; Reviewed; Region: recF; PRK00064 378806001442 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001443 Walker A/P-loop; other site 378806001444 ATP binding site [chemical binding]; other site 378806001445 Q-loop/lid; other site 378806001446 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001447 ABC transporter signature motif; other site 378806001448 Walker B; other site 378806001449 D-loop; other site 378806001450 H-loop/switch region; other site 378806001451 Domain of unknown function DUF140; Region: DUF140; cl00510 378806001452 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 378806001453 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 378806001454 Walker A/P-loop; other site 378806001455 ATP binding site [chemical binding]; other site 378806001456 Q-loop/lid; other site 378806001457 ABC transporter signature motif; other site 378806001458 Walker B; other site 378806001459 D-loop; other site 378806001460 H-loop/switch region; other site 378806001461 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 378806001462 mce related protein; Region: MCE; cl03606 378806001463 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 378806001464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806001465 DNA-binding site [nucleotide binding]; DNA binding site 378806001466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806001467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806001468 homodimer interface [polypeptide binding]; other site 378806001469 catalytic residue [active] 378806001470 Putative cyclase; Region: Cyclase; cl00814 378806001471 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806001472 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 378806001473 putative C-terminal domain interface [polypeptide binding]; other site 378806001474 putative GSH binding site (G-site) [chemical binding]; other site 378806001475 putative dimer interface [polypeptide binding]; other site 378806001476 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 378806001477 N-terminal domain interface [polypeptide binding]; other site 378806001478 dimer interface [polypeptide binding]; other site 378806001479 substrate binding pocket (H-site) [chemical binding]; other site 378806001480 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 378806001481 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 378806001482 potential frameshift: common BLAST hit: gi|108759312|ref|YP_629493.1| Ser/Thr kinase family protein 378806001483 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806001484 Protein kinase domain; Region: Pkinase; pfam00069 378806001485 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806001486 active site 378806001487 ATP binding site [chemical binding]; other site 378806001488 substrate binding site [chemical binding]; other site 378806001489 activation loop (A-loop); other site 378806001490 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806001491 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806001492 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 378806001493 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806001494 Cellulose binding domain; Region: CBM_3; pfam00942 378806001495 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 378806001496 active site 378806001497 catalytic residues [active] 378806001498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806001499 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806001500 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 378806001501 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806001502 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806001503 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 378806001504 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 378806001505 putative ADP-binding pocket [chemical binding]; other site 378806001506 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 378806001507 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806001508 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806001509 catalytic residue [active] 378806001510 circadian clock protein KaiC; Reviewed; Region: PRK09302 378806001511 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001512 Walker A motif; other site 378806001513 ATP binding site [chemical binding]; other site 378806001514 Walker B motif; other site 378806001515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001517 Walker A motif; other site 378806001518 Walker A motif; other site 378806001519 ATP binding site [chemical binding]; other site 378806001520 Walker B motif; other site 378806001521 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001523 active site 378806001524 phosphorylation site [posttranslational modification] 378806001525 intermolecular recognition site; other site 378806001526 dimerization interface [polypeptide binding]; other site 378806001527 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 378806001528 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 378806001529 active site 378806001530 metal binding site [ion binding]; metal-binding site 378806001531 alanine racemase; Reviewed; Region: alr; PRK00053 378806001532 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 378806001533 active site 378806001534 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 378806001535 dimer interface [polypeptide binding]; other site 378806001536 substrate binding site [chemical binding]; other site 378806001537 catalytic residues [active] 378806001538 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 378806001539 putative acyl-acceptor binding pocket; other site 378806001540 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 378806001541 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 378806001542 Zn binding site [ion binding]; other site 378806001543 enoyl-CoA hydratase; Provisional; Region: PRK06688 378806001544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806001545 substrate binding site [chemical binding]; other site 378806001546 oxyanion hole (OAH) forming residues; other site 378806001547 trimer interface [polypeptide binding]; other site 378806001548 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 378806001549 Cupin domain; Region: Cupin_2; cl09118 378806001550 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806001551 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 378806001552 putative active site [active] 378806001553 putative substrate binding site [chemical binding]; other site 378806001554 catalytic site [active] 378806001555 dimer interface [polypeptide binding]; other site 378806001556 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001558 active site 378806001559 phosphorylation site [posttranslational modification] 378806001560 intermolecular recognition site; other site 378806001561 dimerization interface [polypeptide binding]; other site 378806001562 circadian clock protein KaiC; Reviewed; Region: PRK09302 378806001563 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001564 Walker A motif; other site 378806001565 ATP binding site [chemical binding]; other site 378806001566 Walker B motif; other site 378806001567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001568 Walker A motif; other site 378806001569 ATP binding site [chemical binding]; other site 378806001570 Walker B motif; other site 378806001571 Myxococcus xanthus paralogous family TIGR02265; Region: Mxa_TIGR02265 378806001572 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001574 active site 378806001575 phosphorylation site [posttranslational modification] 378806001576 intermolecular recognition site; other site 378806001577 dimerization interface [polypeptide binding]; other site 378806001578 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806001579 GAF domain; Region: GAF; cl00853 378806001580 GAF domain; Region: GAF; cl00853 378806001581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806001582 dimer interface [polypeptide binding]; other site 378806001583 phosphorylation site [posttranslational modification] 378806001584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001585 ATP binding site [chemical binding]; other site 378806001586 Mg2+ binding site [ion binding]; other site 378806001587 G-X-G motif; other site 378806001588 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 378806001589 GRAS family transcription factor; Region: GRAS; pfam03514 378806001590 Competence-damaged protein; Region: CinA; cl00666 378806001591 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 378806001592 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806001593 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 378806001594 HipA N-terminal domain; Region: couple_hipA; TIGR03071 378806001595 HipA-like N-terminal domain; Region: HipA_N; pfam07805 378806001596 HipA-like C-terminal domain; Region: HipA_C; pfam07804 378806001597 Protein of unknown function DUF262; Region: DUF262; cl14890 378806001598 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 378806001599 Uncharacterized conserved protein [Function unknown]; Region: COG1572 378806001600 CARDB; Region: CARDB; pfam07705 378806001601 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 378806001602 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 378806001603 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 378806001604 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 378806001605 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806001606 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806001607 active site 378806001608 catalytic tetrad [active] 378806001609 Dienelactone hydrolase family; Region: DLH; pfam01738 378806001610 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 378806001611 GSH binding site [chemical binding]; other site 378806001612 catalytic residues [active] 378806001613 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-...; Region: SCP_PR-1_like; cd05381 378806001614 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 378806001615 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-...; Region: R3H; cl00297 378806001616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806001617 SEC-C motif; Region: SEC-C; cl12132 378806001618 methionine aminopeptidase; Provisional; Region: PRK12318 378806001619 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 378806001620 active site 378806001621 Isochorismatase family; Region: Isochorismatase; pfam00857 378806001622 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 378806001623 catalytic triad [active] 378806001624 dimer interface [polypeptide binding]; other site 378806001625 conserved cis-peptide bond; other site 378806001626 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 378806001627 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 378806001628 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 378806001629 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 378806001630 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806001631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806001632 NAD(P) binding site [chemical binding]; other site 378806001633 active site 378806001634 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 378806001635 putative active site [active] 378806001636 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806001637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806001638 DNA-binding site [nucleotide binding]; DNA binding site 378806001639 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806001640 active site 378806001641 ATP binding site [chemical binding]; other site 378806001642 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806001643 substrate binding site [chemical binding]; other site 378806001644 activation loop (A-loop); other site 378806001645 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 378806001646 MgtC family; Region: MgtC; cl12207 378806001647 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 378806001648 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 378806001649 TMP-binding site; other site 378806001650 ATP-binding site [chemical binding]; other site 378806001651 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 378806001652 putative active site; other site 378806001653 putative triphosphate binding site [ion binding]; other site 378806001654 putative metal binding residues [ion binding]; other site 378806001655 CotH protein; Region: CotH; pfam08757 378806001656 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 378806001657 Kelch motif; Region: Kelch_1; cl02701 378806001658 Kelch motif; Region: Kelch_1; cl02701 378806001659 Kelch motif; Region: Kelch_1; cl02701 378806001660 kelch-like protein; Provisional; Region: PHA03098 378806001661 Kelch motif; Region: Kelch_1; cl02701 378806001662 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 378806001663 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 378806001664 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806001665 extended (e) SDRs; Region: SDR_e; cd08946 378806001666 NAD(P) binding site [chemical binding]; other site 378806001667 active site 378806001668 substrate binding site [chemical binding]; other site 378806001669 phosphoenolpyruvate synthase; Validated; Region: PRK06241 378806001670 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 378806001671 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 378806001672 UbiA prenyltransferase family; Region: UbiA; cl00337 378806001673 multidrug efflux protein; Reviewed; Region: PRK09579 378806001674 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806001675 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 378806001676 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 378806001677 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 378806001678 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 378806001679 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 378806001680 hypothetical protein; Provisional; Region: PRK09133 378806001681 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 378806001682 putative metal binding site [ion binding]; other site 378806001683 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 378806001684 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 378806001685 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 378806001686 active site 378806001687 Protein of unknown function (DUF819); Region: DUF819; cl02317 378806001688 BB1 family; Region: BB1; pfam08185 378806001689 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 378806001690 active site 378806001691 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806001692 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806001693 active site 378806001694 catalytic tetrad [active] 378806001695 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 378806001696 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806001697 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806001698 catalytic residue [active] 378806001699 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378806001700 putative acyl-acceptor binding pocket; other site 378806001701 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 378806001702 homotrimer interaction site [polypeptide binding]; other site 378806001703 putative active site [active] 378806001704 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806001705 active site 378806001706 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 378806001707 RNA/DNA hybrid binding site [nucleotide binding]; other site 378806001708 active site 378806001709 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806001710 phosphopeptide binding site; other site 378806001711 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806001712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806001713 Walker A motif; other site 378806001714 ATP binding site [chemical binding]; other site 378806001715 Walker B motif; other site 378806001716 arginine finger; other site 378806001717 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806001718 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806001719 active site 378806001720 ATP binding site [chemical binding]; other site 378806001721 substrate binding site [chemical binding]; other site 378806001722 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806001723 activation loop (A-loop); other site 378806001724 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806001725 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806001726 active site 378806001727 ATP binding site [chemical binding]; other site 378806001728 substrate binding site [chemical binding]; other site 378806001729 activation loop (A-loop); other site 378806001730 Predicted ATPase [General function prediction only]; Region: COG3899 378806001731 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 378806001732 active site 378806001733 catalytic triad [active] 378806001734 oxyanion hole [active] 378806001735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806001736 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806001737 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806001738 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806001739 active site 378806001740 ATP binding site [chemical binding]; other site 378806001741 substrate binding site [chemical binding]; other site 378806001742 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806001743 activation loop (A-loop); other site 378806001744 Predicted ATPase [General function prediction only]; Region: COG4637 378806001745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001746 putative oligopeptide transporter, OPT family; Region: TIGR00733 378806001747 OPT oligopeptide transporter protein; Region: OPT; cl14607 378806001748 OPT oligopeptide transporter protein; Region: OPT; cl14607 378806001749 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 378806001750 cyclase homology domain; Region: CHD; cd07302 378806001751 nucleotidyl binding site; other site 378806001752 metal binding site [ion binding]; metal-binding site 378806001753 dimer interface [polypeptide binding]; other site 378806001754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806001755 TPR motif; other site 378806001756 binding surface 378806001757 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806001758 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806001759 metal binding site [ion binding]; metal-binding site 378806001760 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806001761 phosphopeptide binding site; other site 378806001762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806001763 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 378806001764 Walker A motif; other site 378806001765 ATP binding site [chemical binding]; other site 378806001766 Walker B motif; other site 378806001767 arginine finger; other site 378806001768 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806001769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806001770 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378806001771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001772 active site 378806001773 phosphorylation site [posttranslational modification] 378806001774 intermolecular recognition site; other site 378806001775 dimerization interface [polypeptide binding]; other site 378806001776 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806001777 DNA binding site [nucleotide binding] 378806001778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806001779 dimer interface [polypeptide binding]; other site 378806001780 phosphorylation site [posttranslational modification] 378806001781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001782 ATP binding site [chemical binding]; other site 378806001783 Mg2+ binding site [ion binding]; other site 378806001784 G-X-G motif; other site 378806001785 von Willebrand factor; Region: vWF_A; pfam12450 378806001786 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 378806001787 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_subgroup; cd01465 378806001788 metal ion-dependent adhesion site (MIDAS); other site 378806001789 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 378806001790 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 378806001791 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806001792 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 378806001793 Peptidase family M48; Region: Peptidase_M48; cl12018 378806001794 CHASE2 domain; Region: CHASE2; cl01732 378806001795 CHASE2 domain; Region: CHASE2; cl01732 378806001796 cyclase homology domain; Region: CHD; cd07302 378806001797 nucleotidyl binding site; other site 378806001798 metal binding site [ion binding]; metal-binding site 378806001799 dimer interface [polypeptide binding]; other site 378806001800 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806001801 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 378806001802 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806001803 Fatty acid desaturase; Region: FA_desaturase; pfam00487 378806001804 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 378806001805 putative di-iron ligands [ion binding]; other site 378806001806 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806001807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806001808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806001809 DNA binding residues [nucleotide binding] 378806001810 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 378806001811 dimer interface [polypeptide binding]; other site 378806001812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806001813 S-adenosylmethionine binding site [chemical binding]; other site 378806001814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806001815 binding surface 378806001816 TPR motif; other site 378806001817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806001818 binding surface 378806001819 TPR motif; other site 378806001820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806001821 binding surface 378806001822 TPR motif; other site 378806001823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806001824 binding surface 378806001825 TPR motif; other site 378806001826 CHAT domain; Region: CHAT; cl02083 378806001827 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 378806001828 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 378806001829 CutC family; Region: CutC; cl01218 378806001830 Protein of unknown function (DUF962); Region: DUF962; cl01879 378806001831 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 378806001832 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 378806001833 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 378806001834 active site 378806001835 metal binding site [ion binding]; metal-binding site 378806001836 GAF domain; Region: GAF; cl00853 378806001837 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806001838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806001839 dimer interface [polypeptide binding]; other site 378806001840 phosphorylation site [posttranslational modification] 378806001841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001842 ATP binding site [chemical binding]; other site 378806001843 Mg2+ binding site [ion binding]; other site 378806001844 G-X-G motif; other site 378806001845 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 378806001846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806001847 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 378806001848 NmrA-like family; Region: NmrA; pfam05368 378806001849 NADP binding site [chemical binding]; other site 378806001850 active site 378806001851 regulatory binding site [polypeptide binding]; other site 378806001852 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806001853 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 378806001854 SprT-like family; Region: SprT-like; pfam10263 378806001855 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 378806001856 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 378806001857 Ycf48-like protein; Provisional; Region: PRK13684 378806001858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806001859 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806001860 ligand binding site [chemical binding]; other site 378806001861 flexible hinge region; other site 378806001862 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806001863 ligand binding site [chemical binding]; other site 378806001864 flexible hinge region; other site 378806001865 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806001866 ligand binding site [chemical binding]; other site 378806001867 flexible hinge region; other site 378806001868 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806001869 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806001870 active site 378806001871 catalytic tetrad [active] 378806001872 SEC-C motif; Region: SEC-C; cl12132 378806001873 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 378806001874 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 378806001875 iron-sulfur cluster [ion binding]; other site 378806001876 [2Fe-2S] cluster binding site [ion binding]; other site 378806001877 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 378806001878 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806001879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001880 active site 378806001881 phosphorylation site [posttranslational modification] 378806001882 intermolecular recognition site; other site 378806001883 dimerization interface [polypeptide binding]; other site 378806001884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806001885 Walker A motif; other site 378806001886 ATP binding site [chemical binding]; other site 378806001887 Walker B motif; other site 378806001888 arginine finger; other site 378806001889 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806001890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806001891 dimer interface [polypeptide binding]; other site 378806001892 phosphorylation site [posttranslational modification] 378806001893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001894 ATP binding site [chemical binding]; other site 378806001895 Mg2+ binding site [ion binding]; other site 378806001896 G-X-G motif; other site 378806001897 Outer membrane efflux protein; Region: OEP; pfam02321 378806001898 Outer membrane efflux protein; Region: OEP; pfam02321 378806001899 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806001900 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378806001901 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001902 Walker A/P-loop; other site 378806001903 ATP binding site [chemical binding]; other site 378806001904 Q-loop/lid; other site 378806001905 ABC transporter signature motif; other site 378806001906 Walker B; other site 378806001907 D-loop; other site 378806001908 H-loop/switch region; other site 378806001909 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806001910 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 378806001911 Walker A/P-loop; other site 378806001912 ATP binding site [chemical binding]; other site 378806001913 Q-loop/lid; other site 378806001914 ABC transporter signature motif; other site 378806001915 Walker B; other site 378806001916 D-loop; other site 378806001917 H-loop/switch region; other site 378806001918 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 378806001919 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806001920 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 378806001921 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806001922 peptide synthase; Validated; Region: PRK05691 378806001923 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806001924 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806001925 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806001926 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 378806001927 active site 378806001928 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 378806001929 Glutamine amidotransferase class-I; Region: GATase; pfam00117 378806001930 glutamine binding [chemical binding]; other site 378806001931 catalytic triad [active] 378806001932 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 378806001933 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 378806001934 chorismate binding enzyme; Region: Chorismate_bind; cl10555 378806001935 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806001936 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 378806001937 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 378806001938 homodimer interface [polypeptide binding]; other site 378806001939 substrate-cofactor binding pocket; other site 378806001940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806001941 catalytic residue [active] 378806001942 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 378806001943 hydrophobic ligand binding site; other site 378806001944 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 378806001945 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 378806001946 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 378806001947 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 378806001948 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 378806001949 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 378806001950 active site 378806001951 nucleophile elbow; other site 378806001952 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 378806001953 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 378806001954 Ligand binding site [chemical binding]; other site 378806001955 metal binding site [ion binding]; metal-binding site 378806001956 H+ Antiporter protein; Region: 2A0121; TIGR00900 378806001957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806001958 putative substrate translocation pore; other site 378806001959 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806001960 ligand binding site [chemical binding]; other site 378806001961 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 378806001962 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 378806001963 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 378806001964 beta subunit interaction interface [polypeptide binding]; other site 378806001965 Walker A motif; other site 378806001966 ATP binding site [chemical binding]; other site 378806001967 Walker B motif; other site 378806001968 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 378806001969 PAS fold; Region: PAS_4; pfam08448 378806001970 PAS domain S-box; Region: sensory_box; TIGR00229 378806001971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806001972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806001973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806001974 ATP binding site [chemical binding]; other site 378806001975 Mg2+ binding site [ion binding]; other site 378806001976 G-X-G motif; other site 378806001977 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 378806001978 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 378806001979 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 378806001980 Response regulator receiver domain; Region: Response_reg; pfam00072 378806001981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001982 active site 378806001983 phosphorylation site [posttranslational modification] 378806001984 intermolecular recognition site; other site 378806001985 dimerization interface [polypeptide binding]; other site 378806001986 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806001987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806001988 active site 378806001989 phosphorylation site [posttranslational modification] 378806001990 intermolecular recognition site; other site 378806001991 PilZ domain; Region: PilZ; cl01260 378806001992 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats [General function prediction only]; Region: COG4880 378806001993 Beta propeller domain; Region: Beta_propel; pfam09826 378806001994 multidrug efflux protein; Reviewed; Region: PRK01766 378806001995 MatE; Region: MatE; pfam01554 378806001996 MatE; Region: MatE; pfam01554 378806001997 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806001998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806001999 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 378806002000 Walker A motif; other site 378806002001 ATP binding site [chemical binding]; other site 378806002002 Walker B motif; other site 378806002003 arginine finger; other site 378806002004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806002005 binding surface 378806002006 TPR motif; other site 378806002007 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806002008 binding surface 378806002009 TPR motif; other site 378806002010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806002011 binding surface 378806002012 TPR motif; other site 378806002013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806002014 binding surface 378806002015 TPR motif; other site 378806002016 CHAT domain; Region: CHAT; cl02083 378806002017 Protein kinase domain; Region: Pkinase; pfam00069 378806002018 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002019 active site 378806002020 ATP binding site [chemical binding]; other site 378806002021 substrate binding site [chemical binding]; other site 378806002022 activation loop (A-loop); other site 378806002023 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 378806002024 NADP binding site [chemical binding]; other site 378806002025 active site 378806002026 steroid binding site; other site 378806002027 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 378806002028 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 378806002029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806002030 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806002031 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806002032 active site 378806002033 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806002034 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806002035 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002036 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806002037 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 378806002038 inhibitor-cofactor binding pocket; inhibition site 378806002039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806002040 catalytic residue [active] 378806002041 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 378806002042 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 378806002043 Condensation domain; Region: Condensation; cl09290 378806002044 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806002045 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 378806002046 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002047 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002048 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 378806002049 Thioesterase domain; Region: Thioesterase; pfam00975 378806002050 Cytochrome P450; Region: p450; cl12078 378806002051 acyl-CoA synthetase; Validated; Region: PRK05850 378806002052 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002053 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002054 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002055 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 378806002056 classical (c) SDRs; Region: SDR_c; cd05233 378806002057 NAD(P) binding site [chemical binding]; other site 378806002058 active site 378806002059 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 378806002060 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 378806002061 active site 378806002062 Zn binding site [ion binding]; other site 378806002063 Domain of unknown function DUF28; Region: DUF28; cl00361 378806002064 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 378806002065 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806002066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806002067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806002068 NAD(P) binding site [chemical binding]; other site 378806002069 active site 378806002070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806002071 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 378806002072 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378806002073 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 378806002074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002075 active site 378806002076 ATP binding site [chemical binding]; other site 378806002077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806002078 substrate binding site [chemical binding]; other site 378806002079 activation loop (A-loop); other site 378806002080 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 378806002081 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806002082 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002084 active site 378806002085 phosphorylation site [posttranslational modification] 378806002086 intermolecular recognition site; other site 378806002087 dimerization interface [polypeptide binding]; other site 378806002088 PAS domain S-box; Region: sensory_box; TIGR00229 378806002089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806002090 putative active site [active] 378806002091 heme pocket [chemical binding]; other site 378806002092 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806002093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002094 dimer interface [polypeptide binding]; other site 378806002095 phosphorylation site [posttranslational modification] 378806002096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002097 ATP binding site [chemical binding]; other site 378806002098 Mg2+ binding site [ion binding]; other site 378806002099 G-X-G motif; other site 378806002100 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002102 active site 378806002103 phosphorylation site [posttranslational modification] 378806002104 intermolecular recognition site; other site 378806002105 dimerization interface [polypeptide binding]; other site 378806002106 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806002107 active site 378806002108 ATP binding site [chemical binding]; other site 378806002109 substrate binding site [chemical binding]; other site 378806002110 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806002111 substrate binding site [chemical binding]; other site 378806002112 activation loop (A-loop); other site 378806002113 activation loop (A-loop); other site 378806002114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806002115 non-specific DNA binding site [nucleotide binding]; other site 378806002116 salt bridge; other site 378806002117 sequence-specific DNA binding site [nucleotide binding]; other site 378806002118 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806002119 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806002120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002121 dimer interface [polypeptide binding]; other site 378806002122 phosphorylation site [posttranslational modification] 378806002123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002124 ATP binding site [chemical binding]; other site 378806002125 Mg2+ binding site [ion binding]; other site 378806002126 G-X-G motif; other site 378806002127 Myxococcus xanthus paralogous lipoprotein family TIGR02269; Region: TIGR02269 378806002128 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 378806002129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806002130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806002131 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 378806002132 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806002133 putative active site [active] 378806002134 putative metal binding site [ion binding]; other site 378806002135 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 378806002136 metal binding site 2 [ion binding]; metal-binding site 378806002137 putative DNA binding helix; other site 378806002138 metal binding site 1 [ion binding]; metal-binding site 378806002139 dimer interface [polypeptide binding]; other site 378806002140 structural Zn2+ binding site [ion binding]; other site 378806002141 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 378806002142 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 378806002143 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 378806002144 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002146 active site 378806002147 phosphorylation site [posttranslational modification] 378806002148 intermolecular recognition site; other site 378806002149 dimerization interface [polypeptide binding]; other site 378806002150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806002151 PAS fold; Region: PAS_3; pfam08447 378806002152 putative active site [active] 378806002153 heme pocket [chemical binding]; other site 378806002154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002155 dimer interface [polypeptide binding]; other site 378806002156 phosphorylation site [posttranslational modification] 378806002157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002158 ATP binding site [chemical binding]; other site 378806002159 Mg2+ binding site [ion binding]; other site 378806002160 G-X-G motif; other site 378806002161 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 378806002162 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806002163 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806002164 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806002165 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806002166 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806002167 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002169 active site 378806002170 phosphorylation site [posttranslational modification] 378806002171 intermolecular recognition site; other site 378806002172 dimerization interface [polypeptide binding]; other site 378806002173 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 378806002174 putative binding surface; other site 378806002175 active site 378806002176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806002177 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 378806002178 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806002179 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806002180 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806002181 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806002182 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806002183 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 378806002184 Chromosome condensation complex Condensin, subunit G [Chromatin structure and dynamics / Cell division and chromosome partitioning]; Region: YCG1; COG5218 378806002185 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 378806002186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806002187 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 378806002188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002189 active site 378806002190 phosphorylation site [posttranslational modification] 378806002191 intermolecular recognition site; other site 378806002192 CheB methylesterase; Region: CheB_methylest; pfam01339 378806002193 putative diguanylate cyclase; Provisional; Region: PRK09776 378806002194 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 378806002195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806002196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002197 dimer interface [polypeptide binding]; other site 378806002198 phosphorylation site [posttranslational modification] 378806002199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002200 ATP binding site [chemical binding]; other site 378806002201 Mg2+ binding site [ion binding]; other site 378806002202 G-X-G motif; other site 378806002203 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 378806002204 GAF domain; Region: GAF; cl00853 378806002205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806002206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002207 dimer interface [polypeptide binding]; other site 378806002208 phosphorylation site [posttranslational modification] 378806002209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002210 ATP binding site [chemical binding]; other site 378806002211 Mg2+ binding site [ion binding]; other site 378806002212 G-X-G motif; other site 378806002213 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 378806002214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002215 active site 378806002216 phosphorylation site [posttranslational modification] 378806002217 intermolecular recognition site; other site 378806002218 dimerization interface [polypeptide binding]; other site 378806002219 CheB methylesterase; Region: CheB_methylest; pfam01339 378806002220 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 378806002221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 378806002222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002223 ATP binding site [chemical binding]; other site 378806002224 Mg2+ binding site [ion binding]; other site 378806002225 G-X-G motif; other site 378806002226 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806002227 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002229 active site 378806002230 phosphorylation site [posttranslational modification] 378806002231 intermolecular recognition site; other site 378806002232 dimerization interface [polypeptide binding]; other site 378806002233 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 378806002234 CHASE3 domain; Region: CHASE3; cl05000 378806002235 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806002236 dimerization interface [polypeptide binding]; other site 378806002237 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806002238 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806002239 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806002240 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 378806002241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806002242 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806002243 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 378806002244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806002245 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806002246 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806002247 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806002248 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002249 active site 378806002250 ATP binding site [chemical binding]; other site 378806002251 substrate binding site [chemical binding]; other site 378806002252 activation loop (A-loop); other site 378806002253 Protein kinase domain; Region: Pkinase; pfam00069 378806002254 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002255 active site 378806002256 ATP binding site [chemical binding]; other site 378806002257 substrate binding site [chemical binding]; other site 378806002258 activation loop (A-loop); other site 378806002259 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806002260 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806002261 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806002262 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 378806002263 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 378806002264 protein-splicing catalytic site; other site 378806002265 thioester formation/cholesterol transfer; other site 378806002266 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 378806002267 Phage capsid family; Region: Phage_capsid; pfam05065 378806002268 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 378806002269 Phage-related protein [Function unknown]; Region: COG4695; cl01923 378806002270 Uncharacterized conserved protein [Function unknown]; Region: COG5323 378806002271 Virulence-associated protein E; Region: VirE; pfam05272 378806002272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806002273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806002274 Superfamily II helicase [General function prediction only]; Region: COG1204 378806002275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806002276 nucleotide binding region [chemical binding]; other site 378806002277 ATP-binding site [chemical binding]; other site 378806002278 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002279 active site 378806002280 ATP binding site [chemical binding]; other site 378806002281 substrate binding site [chemical binding]; other site 378806002282 activation loop (A-loop); other site 378806002283 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 378806002284 active site 378806002285 DNA binding site [nucleotide binding] 378806002286 catalytic site [active] 378806002287 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378806002288 Phage integrase family; Region: Phage_integrase; pfam00589 378806002289 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806002290 DNA binding site [nucleotide binding] 378806002291 Int/Topo IB signature motif; other site 378806002292 active site 378806002293 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806002294 active site 378806002295 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 378806002296 CsbD-like; Region: CsbD; cl01272 378806002297 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 378806002298 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806002299 Walker A/P-loop; other site 378806002300 ATP binding site [chemical binding]; other site 378806002301 Q-loop/lid; other site 378806002302 ABC transporter signature motif; other site 378806002303 Walker B; other site 378806002304 D-loop; other site 378806002305 H-loop/switch region; other site 378806002306 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806002307 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806002308 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 378806002309 catalytic residues [active] 378806002310 CotH protein; Region: CotH; pfam08757 378806002311 Domain of unknown function DUF20; Region: UPF0118; cl00465 378806002312 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 378806002313 putative active site [active] 378806002314 ATP synthase; Region: ATP-synt; cl00365 378806002315 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806002316 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 378806002317 active site 378806002318 catalytic tetrad [active] 378806002319 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 378806002320 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 378806002321 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 378806002322 alpha subunit interaction interface [polypeptide binding]; other site 378806002323 Walker A motif; other site 378806002324 ATP binding site [chemical binding]; other site 378806002325 Walker B motif; other site 378806002326 inhibitor binding site; inhibition site 378806002327 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 378806002328 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 378806002329 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 378806002330 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 378806002331 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 378806002332 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 378806002333 active site 378806002334 dimer interface [polypeptide binding]; other site 378806002335 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 378806002336 dimer interface [polypeptide binding]; other site 378806002337 active site 378806002338 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 378806002339 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 378806002340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806002341 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 378806002342 G1 box; other site 378806002343 GTP/Mg2+ binding site [chemical binding]; other site 378806002344 Switch I region; other site 378806002345 G2 box; other site 378806002346 Switch II region; other site 378806002347 G3 box; other site 378806002348 G4 box; other site 378806002349 G5 box; other site 378806002350 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 378806002351 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 378806002352 AlkA N-terminal domain; Region: AlkA_N; pfam06029 378806002353 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 378806002354 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 378806002355 minor groove reading motif; other site 378806002356 helix-hairpin-helix signature motif; other site 378806002357 substrate binding pocket [chemical binding]; other site 378806002358 active site 378806002359 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 378806002360 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 378806002361 DNA binding site [nucleotide binding] 378806002362 active site 378806002363 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 378806002364 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 378806002365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806002366 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806002367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806002368 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 378806002369 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 378806002370 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 378806002371 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to...; Region: CBM20_alpha_amylase; cd05808 378806002372 starch-binding site 2 [chemical binding]; other site 378806002373 starch-binding site 1 [chemical binding]; other site 378806002374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806002375 Protein of unknown function, DUF393; Region: DUF393; cl01136 378806002376 Protein of unknown function (DUF1222); Region: DUF1222; pfam06762 378806002377 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 378806002378 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806002379 ligand binding site [chemical binding]; other site 378806002380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806002381 non-specific DNA binding site [nucleotide binding]; other site 378806002382 salt bridge; other site 378806002383 sequence-specific DNA binding site [nucleotide binding]; other site 378806002384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806002385 non-specific DNA binding site [nucleotide binding]; other site 378806002386 salt bridge; other site 378806002387 sequence-specific DNA binding site [nucleotide binding]; other site 378806002388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806002389 non-specific DNA binding site [nucleotide binding]; other site 378806002390 salt bridge; other site 378806002391 sequence-specific DNA binding site [nucleotide binding]; other site 378806002392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806002393 non-specific DNA binding site [nucleotide binding]; other site 378806002394 salt bridge; other site 378806002395 sequence-specific DNA binding site [nucleotide binding]; other site 378806002396 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806002397 G1 box; other site 378806002398 GTP/Mg2+ binding site [chemical binding]; other site 378806002399 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 378806002400 catalytic residues [active] 378806002401 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806002402 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806002403 transcriptional regulator NarL; Provisional; Region: PRK10651 378806002404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806002405 DNA binding residues [nucleotide binding] 378806002406 dimerization interface [polypeptide binding]; other site 378806002407 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806002408 Dienelactone hydrolase family; Region: DLH; pfam01738 378806002409 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 378806002410 C-term; Region: GreA_GreB; pfam01272 378806002411 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806002412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806002413 NAD(P) binding site [chemical binding]; other site 378806002414 active site 378806002415 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 378806002416 classical (c) SDRs; Region: SDR_c; cd05233 378806002417 NAD(P) binding site [chemical binding]; other site 378806002418 active site 378806002419 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 378806002420 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 378806002421 active site 378806002422 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 378806002423 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806002424 GAF domain; Region: GAF; cl00853 378806002425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806002426 PAS domain S-box; Region: sensory_box; TIGR00229 378806002427 PAS domain S-box; Region: sensory_box; TIGR00229 378806002428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806002429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806002430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002431 dimer interface [polypeptide binding]; other site 378806002432 phosphorylation site [posttranslational modification] 378806002433 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806002434 GAF domain; Region: GAF; cl00853 378806002435 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806002436 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806002437 putative active site [active] 378806002438 heme pocket [chemical binding]; other site 378806002439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002440 dimer interface [polypeptide binding]; other site 378806002441 phosphorylation site [posttranslational modification] 378806002442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002443 ATP binding site [chemical binding]; other site 378806002444 Mg2+ binding site [ion binding]; other site 378806002445 G-X-G motif; other site 378806002446 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806002447 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 378806002448 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806002449 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806002450 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 378806002451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806002452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806002453 motif II; other site 378806002454 MASE1; Region: MASE1; pfam05231 378806002455 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806002456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806002457 putative active site [active] 378806002458 heme pocket [chemical binding]; other site 378806002459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002460 dimer interface [polypeptide binding]; other site 378806002461 phosphorylation site [posttranslational modification] 378806002462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002463 ATP binding site [chemical binding]; other site 378806002464 Mg2+ binding site [ion binding]; other site 378806002465 G-X-G motif; other site 378806002466 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002468 active site 378806002469 phosphorylation site [posttranslational modification] 378806002470 intermolecular recognition site; other site 378806002471 dimerization interface [polypeptide binding]; other site 378806002472 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 378806002473 Found in ATP-dependent protease La (LON); Region: LON; cl01056 378806002474 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 378806002475 NAD synthetase; Provisional; Region: PRK13981 378806002476 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 378806002477 multimer interface [polypeptide binding]; other site 378806002478 active site 378806002479 catalytic triad [active] 378806002480 protein interface 1 [polypeptide binding]; other site 378806002481 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 378806002482 homodimer interface [polypeptide binding]; other site 378806002483 NAD binding pocket [chemical binding]; other site 378806002484 ATP binding pocket [chemical binding]; other site 378806002485 Mg binding site [ion binding]; other site 378806002486 active-site loop [active] 378806002487 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 378806002488 Domain of unknown function DUF21; Region: DUF21; pfam01595 378806002489 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 378806002490 Transporter associated domain; Region: CorC_HlyC; pfam03471 378806002491 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 378806002492 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 378806002493 catalytic residues [active] 378806002494 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 378806002495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806002496 motif II; other site 378806002497 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806002498 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806002499 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806002500 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 378806002501 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 378806002502 NAD(P) binding site [chemical binding]; other site 378806002503 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806002504 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806002505 active site 378806002506 ATP binding site [chemical binding]; other site 378806002507 substrate binding site [chemical binding]; other site 378806002508 activation loop (A-loop); other site 378806002509 Predicted ATPase [General function prediction only]; Region: COG3899 378806002510 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 378806002511 GAF domain; Region: GAF; cl00853 378806002512 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806002513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002514 ATP binding site [chemical binding]; other site 378806002515 Mg2+ binding site [ion binding]; other site 378806002516 G-X-G motif; other site 378806002517 Late embryogenesis abundant protein; Region: LEA_2; cl12118 378806002518 Late embryogenesis abundant protein; Region: LEA_2; cl12118 378806002519 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 378806002520 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806002521 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 378806002522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806002523 Walker A/P-loop; other site 378806002524 ATP binding site [chemical binding]; other site 378806002525 Q-loop/lid; other site 378806002526 ABC transporter signature motif; other site 378806002527 Walker B; other site 378806002528 D-loop; other site 378806002529 H-loop/switch region; other site 378806002530 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 378806002531 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806002532 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806002533 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 378806002534 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 378806002535 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002536 active site 378806002537 ATP binding site [chemical binding]; other site 378806002538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806002539 substrate binding site [chemical binding]; other site 378806002540 activation loop (A-loop); other site 378806002541 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 378806002542 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 378806002543 active site 378806002544 homotetramer interface [polypeptide binding]; other site 378806002545 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 378806002546 allantoicase; Provisional; Region: PRK13257 378806002547 Allantoicase repeat; Region: Allantoicase; pfam03561 378806002548 Allantoicase repeat; Region: Allantoicase; pfam03561 378806002549 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 378806002550 allantoinase; Region: allantoinase; TIGR03178 378806002551 active site 378806002552 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 378806002553 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806002554 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806002555 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806002556 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 378806002557 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806002558 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 378806002559 ADP-ribose binding site [chemical binding]; other site 378806002560 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 378806002561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806002562 binding surface 378806002563 TPR motif; other site 378806002564 Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481 378806002565 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806002566 catalytic tetrad [active] 378806002567 Protein kinase domain; Region: Pkinase; pfam00069 378806002568 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002569 active site 378806002570 ATP binding site [chemical binding]; other site 378806002571 substrate binding site [chemical binding]; other site 378806002572 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806002573 substrate binding site [chemical binding]; other site 378806002574 activation loop (A-loop); other site 378806002575 activation loop (A-loop); other site 378806002576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806002577 binding surface 378806002578 TPR motif; other site 378806002579 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 378806002580 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 378806002581 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 378806002582 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 378806002583 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 378806002584 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 378806002585 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 378806002586 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 378806002587 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 378806002588 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 378806002589 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 378806002590 Ferritin-like domain; Region: Ferritin; pfam00210 378806002591 heme binding site [chemical binding]; other site 378806002592 ferroxidase pore; other site 378806002593 ferroxidase diiron center [ion binding]; other site 378806002594 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 378806002595 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 378806002596 active site 378806002597 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 378806002598 chitin/cellulose binding site [chemical binding]; other site 378806002599 Protein kinase domain; Region: Pkinase; pfam00069 378806002600 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002601 active site 378806002602 ATP binding site [chemical binding]; other site 378806002603 substrate binding site [chemical binding]; other site 378806002604 activation loop (A-loop); other site 378806002605 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 378806002606 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 378806002607 YceI-like domain; Region: YceI; cl01001 378806002608 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806002609 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806002610 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 378806002611 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 378806002612 Zn binding site [ion binding]; other site 378806002613 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 378806002614 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 378806002615 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806002616 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806002617 active site 378806002618 metal binding site [ion binding]; metal-binding site 378806002619 Cytochrome c [Energy production and conversion]; Region: COG3258 378806002620 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 378806002621 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806002622 cleavage site 378806002623 active site 378806002624 substrate binding sites [chemical binding]; other site 378806002625 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 378806002626 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 378806002627 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 378806002628 FtsX-like permease family; Region: FtsX; pfam02687 378806002629 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 378806002630 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 378806002631 FtsX-like permease family; Region: FtsX; pfam02687 378806002632 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 378806002633 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806002634 NAD(P) binding site [chemical binding]; other site 378806002635 catalytic residues [active] 378806002636 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 378806002637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806002638 catalytic residue [active] 378806002639 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 378806002640 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 378806002641 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 378806002642 eight transmembrane protein EpsH (proposed exosortase); Region: 8TM_EpsH; cl10495 378806002643 PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921 378806002644 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806002645 rod shape-determining protein MreB; Provisional; Region: PRK13927 378806002646 Cell division protein FtsA; Region: FtsA; cl11496 378806002647 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 378806002648 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 378806002649 Ligand binding site [chemical binding]; other site 378806002650 Putative Catalytic site [active] 378806002651 DXD motif; other site 378806002652 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 378806002653 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806002654 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806002655 catalytic residue [active] 378806002656 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 378806002657 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806002658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806002659 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 378806002660 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 378806002661 active site 378806002662 substrate binding site [chemical binding]; other site 378806002663 trimer interface [polypeptide binding]; other site 378806002664 CoA binding site [chemical binding]; other site 378806002665 Cupin domain; Region: Cupin_2; cl09118 378806002666 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 378806002667 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 378806002668 metal binding site [ion binding]; metal-binding site 378806002669 putative dimer interface [polypeptide binding]; other site 378806002670 Cupin domain; Region: Cupin_2; cl09118 378806002671 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 378806002672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806002673 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 378806002674 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 378806002675 Predicted integral membrane protein [Function unknown]; Region: COG0392 378806002676 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 378806002677 Uncharacterized conserved protein [Function unknown]; Region: COG2898 378806002678 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 378806002679 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002681 active site 378806002682 phosphorylation site [posttranslational modification] 378806002683 intermolecular recognition site; other site 378806002684 dimerization interface [polypeptide binding]; other site 378806002685 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 378806002686 substrate binding pocket [chemical binding]; other site 378806002687 substrate-Mg2+ binding site; other site 378806002688 aspartate-rich region 1; other site 378806002689 active site lid residues [active] 378806002690 aspartate-rich region 2; other site 378806002691 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 378806002692 substrate binding pocket [chemical binding]; other site 378806002693 substrate-Mg2+ binding site; other site 378806002694 aspartate-rich region 1; other site 378806002695 aspartate-rich region 2; other site 378806002696 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806002697 ligand binding site [chemical binding]; other site 378806002698 flexible hinge region; other site 378806002699 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806002700 ligand binding site [chemical binding]; other site 378806002701 flexible hinge region; other site 378806002702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806002703 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 378806002704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806002705 DNA binding residues [nucleotide binding] 378806002706 dimerization interface [polypeptide binding]; other site 378806002707 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 378806002708 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 378806002709 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 378806002710 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 378806002711 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806002712 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806002713 Protein kinase domain; Region: Pkinase; pfam00069 378806002714 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002715 active site 378806002716 ATP binding site [chemical binding]; other site 378806002717 substrate binding site [chemical binding]; other site 378806002718 activation loop (A-loop); other site 378806002719 Deoxyhypusine synthase; Region: DS; cl00826 378806002720 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 378806002721 aromatic arch; other site 378806002722 DCoH dimer interaction site [polypeptide binding]; other site 378806002723 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 378806002724 DCoH tetramer interaction site [polypeptide binding]; other site 378806002725 substrate binding site [chemical binding]; other site 378806002726 glycerol kinase; Provisional; Region: glpK; PRK00047 378806002727 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806002728 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 378806002729 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806002730 phosphopeptide binding site; other site 378806002731 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 378806002732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806002733 putative substrate translocation pore; other site 378806002734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806002735 non-specific DNA binding site [nucleotide binding]; other site 378806002736 salt bridge; other site 378806002737 sequence-specific DNA binding site [nucleotide binding]; other site 378806002738 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 378806002739 active site 378806002740 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 378806002741 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 378806002742 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 378806002743 Ligand Binding Site [chemical binding]; other site 378806002744 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 378806002745 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 378806002746 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 378806002747 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378806002748 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 378806002749 Walker A/P-loop; other site 378806002750 ATP binding site [chemical binding]; other site 378806002751 Q-loop/lid; other site 378806002752 ABC transporter signature motif; other site 378806002753 Walker B; other site 378806002754 D-loop; other site 378806002755 H-loop/switch region; other site 378806002756 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806002757 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806002758 active site 378806002759 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806002760 PKS_DH; Region: PKS_DH; smart00826 378806002761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806002762 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 378806002763 Enoylreductase; Region: PKS_ER; smart00829 378806002764 NAD(P) binding site [chemical binding]; other site 378806002765 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806002766 putative NADP binding site [chemical binding]; other site 378806002767 active site 378806002768 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002769 Condensation domain; Region: Condensation; cl09290 378806002770 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002771 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806002772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806002773 S-adenosylmethionine binding site [chemical binding]; other site 378806002774 peptide synthase; Validated; Region: PRK05691 378806002775 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002776 Condensation domain; Region: Condensation; cl09290 378806002777 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806002778 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002779 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002780 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002781 Condensation domain; Region: Condensation; cl09290 378806002782 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 378806002783 Condensation domain; Region: Condensation; cl09290 378806002784 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002785 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806002786 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002787 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002788 Condensation domain; Region: Condensation; cl09290 378806002789 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806002790 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002791 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002792 Condensation domain; Region: Condensation; cl09290 378806002793 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806002794 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002795 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002796 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 378806002797 Condensation domain; Region: Condensation; cl09290 378806002798 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806002799 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806002800 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806002801 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 378806002802 Esterase/lipase [General function prediction only]; Region: COG1647 378806002803 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 378806002804 cell division protein ZipA; Provisional; Region: PRK03427 378806002805 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 378806002806 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806002807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806002808 DNA binding residues [nucleotide binding] 378806002809 Cupin domain; Region: Cupin_2; cl09118 378806002810 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 378806002811 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 378806002812 putative active site [active] 378806002813 putative active site [active] 378806002814 catalytic site [active] 378806002815 catalytic site [active] 378806002816 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 378806002817 putative active site [active] 378806002818 catalytic site [active] 378806002819 Cupin domain; Region: Cupin_2; cl09118 378806002820 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806002821 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 378806002822 putative C-terminal domain interface [polypeptide binding]; other site 378806002823 putative GSH binding site (G-site) [chemical binding]; other site 378806002824 putative dimer interface [polypeptide binding]; other site 378806002825 GST_C family, unknown subfamily 1; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_1; cd03179 378806002826 putative N-terminal domain interface [polypeptide binding]; other site 378806002827 putative dimer interface [polypeptide binding]; other site 378806002828 putative substrate binding pocket (H-site) [chemical binding]; other site 378806002829 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 378806002830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806002831 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 378806002832 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806002833 ligand binding site [chemical binding]; other site 378806002834 flexible hinge region; other site 378806002835 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 378806002836 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806002837 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806002838 calcium binding site 2 [ion binding]; other site 378806002839 active site 378806002840 catalytic triad [active] 378806002841 calcium binding site 1 [ion binding]; other site 378806002842 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 378806002843 proposed catalytic triad [active] 378806002844 conserved cys residue [active] 378806002845 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 378806002846 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806002847 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806002848 dimerization interface [polypeptide binding]; other site 378806002849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002850 dimer interface [polypeptide binding]; other site 378806002851 phosphorylation site [posttranslational modification] 378806002852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002853 ATP binding site [chemical binding]; other site 378806002854 Mg2+ binding site [ion binding]; other site 378806002855 G-X-G motif; other site 378806002856 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002857 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002858 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002859 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002860 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002861 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002862 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002863 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002864 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002865 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002866 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002867 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002868 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002869 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806002870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002871 dimer interface [polypeptide binding]; other site 378806002872 phosphorylation site [posttranslational modification] 378806002873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002874 ATP binding site [chemical binding]; other site 378806002875 Mg2+ binding site [ion binding]; other site 378806002876 G-X-G motif; other site 378806002877 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 378806002878 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002880 active site 378806002881 phosphorylation site [posttranslational modification] 378806002882 intermolecular recognition site; other site 378806002883 dimerization interface [polypeptide binding]; other site 378806002884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002885 active site 378806002886 phosphorylation site [posttranslational modification] 378806002887 intermolecular recognition site; other site 378806002888 dimerization interface [polypeptide binding]; other site 378806002889 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002891 active site 378806002892 phosphorylation site [posttranslational modification] 378806002893 intermolecular recognition site; other site 378806002894 dimerization interface [polypeptide binding]; other site 378806002895 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002897 active site 378806002898 phosphorylation site [posttranslational modification] 378806002899 intermolecular recognition site; other site 378806002900 dimerization interface [polypeptide binding]; other site 378806002901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806002902 PAS fold; Region: PAS_3; pfam08447 378806002903 putative active site [active] 378806002904 heme pocket [chemical binding]; other site 378806002905 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806002906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806002907 putative active site [active] 378806002908 heme pocket [chemical binding]; other site 378806002909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002910 dimer interface [polypeptide binding]; other site 378806002911 phosphorylation site [posttranslational modification] 378806002912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002913 ATP binding site [chemical binding]; other site 378806002914 Mg2+ binding site [ion binding]; other site 378806002915 G-X-G motif; other site 378806002916 GAF domain; Region: GAF; cl00853 378806002917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002918 dimer interface [polypeptide binding]; other site 378806002919 phosphorylation site [posttranslational modification] 378806002920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002921 ATP binding site [chemical binding]; other site 378806002922 Mg2+ binding site [ion binding]; other site 378806002923 G-X-G motif; other site 378806002924 Response regulator receiver domain; Region: Response_reg; pfam00072 378806002925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002926 active site 378806002927 phosphorylation site [posttranslational modification] 378806002928 intermolecular recognition site; other site 378806002929 dimerization interface [polypeptide binding]; other site 378806002930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806002931 dimer interface [polypeptide binding]; other site 378806002932 phosphorylation site [posttranslational modification] 378806002933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002934 ATP binding site [chemical binding]; other site 378806002935 Mg2+ binding site [ion binding]; other site 378806002936 G-X-G motif; other site 378806002937 EamA-like transporter family; Region: EamA; cl01037 378806002938 EamA-like transporter family; Region: EamA; cl01037 378806002939 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 378806002940 inter-subunit interface; other site 378806002941 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 378806002942 HrcA protein C terminal domain; Region: HrcA; pfam01628 378806002943 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 378806002944 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 378806002945 active site 378806002946 catalytic residues [active] 378806002947 putative lipid kinase; Reviewed; Region: PRK13057 378806002948 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 378806002949 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806002950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806002951 NAD(P) binding site [chemical binding]; other site 378806002952 active site 378806002953 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 378806002954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806002955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806002956 motif II; other site 378806002957 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 378806002958 active site 378806002959 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 378806002960 putative substrate binding region [chemical binding]; other site 378806002961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806002962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806002963 ATP binding site [chemical binding]; other site 378806002964 Mg2+ binding site [ion binding]; other site 378806002965 G-X-G motif; other site 378806002966 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 378806002967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806002968 active site 378806002969 phosphorylation site [posttranslational modification] 378806002970 intermolecular recognition site; other site 378806002971 dimerization interface [polypeptide binding]; other site 378806002972 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806002973 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 378806002974 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 378806002975 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 378806002976 Ycf48-like protein; Provisional; Region: PRK13684 378806002977 Fusaric acid resistance protein family; Region: FUSC; pfam04632 378806002978 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 378806002979 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806002980 N-terminal plug; other site 378806002981 ligand-binding site [chemical binding]; other site 378806002982 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 378806002983 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806002984 inhibitor-cofactor binding pocket; inhibition site 378806002985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806002986 catalytic residue [active] 378806002987 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806002988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806002989 DNA-binding site [nucleotide binding]; DNA binding site 378806002990 Protein kinase domain; Region: Pkinase; pfam00069 378806002991 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806002992 active site 378806002993 ATP binding site [chemical binding]; other site 378806002994 substrate binding site [chemical binding]; other site 378806002995 activation loop (A-loop); other site 378806002996 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806002997 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806002998 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 378806002999 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806003000 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 378806003001 catalytic residues [active] 378806003002 Peptidase family M48; Region: Peptidase_M48; cl12018 378806003003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806003004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806003005 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378806003006 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806003007 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 378806003008 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 378806003009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806003010 Walker A motif; other site 378806003011 ATP binding site [chemical binding]; other site 378806003012 Walker B motif; other site 378806003013 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 378806003014 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806003015 Walker A motif; other site 378806003016 ATP binding site [chemical binding]; other site 378806003017 Walker B motif; other site 378806003018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806003019 Coenzyme A binding pocket [chemical binding]; other site 378806003020 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 378806003021 G1 box; other site 378806003022 GTP/Mg2+ binding site [chemical binding]; other site 378806003023 G2 box; other site 378806003024 Switch I region; other site 378806003025 G3 box; other site 378806003026 Switch II region; other site 378806003027 G4 box; other site 378806003028 Predicted histidine kinase sensor domain; Region: Hist_Kin_Sens; pfam10114 378806003029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806003030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806003031 dimer interface [polypeptide binding]; other site 378806003032 phosphorylation site [posttranslational modification] 378806003033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003034 ATP binding site [chemical binding]; other site 378806003035 Mg2+ binding site [ion binding]; other site 378806003036 G-X-G motif; other site 378806003037 thiamine monophosphate kinase; Provisional; Region: PRK05731 378806003038 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 378806003039 ATP binding site [chemical binding]; other site 378806003040 dimerization interface [polypeptide binding]; other site 378806003041 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806003042 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806003043 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806003044 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806003045 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806003046 Response regulator receiver domain; Region: Response_reg; pfam00072 378806003047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806003048 active site 378806003049 phosphorylation site [posttranslational modification] 378806003050 intermolecular recognition site; other site 378806003051 dimerization interface [polypeptide binding]; other site 378806003052 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 378806003053 putative binding surface; other site 378806003054 active site 378806003055 P2 response regulator binding domain; Region: P2; pfam07194 378806003056 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 378806003057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003058 ATP binding site [chemical binding]; other site 378806003059 Mg2+ binding site [ion binding]; other site 378806003060 G-X-G motif; other site 378806003061 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806003062 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 378806003063 CheC-like family; Region: CheC; pfam04509 378806003064 AIR carboxylase; Region: AIRC; cl00310 378806003065 Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398 378806003066 Protein of unknown function DUF111; Region: DUF111; pfam01969 378806003067 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378806003068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806003069 Sec24-related protein; Provisional; Region: PTZ00395 378806003070 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806003071 putative catalytic site [active] 378806003072 putative metal binding site [ion binding]; other site 378806003073 putative phosphate binding site [ion binding]; other site 378806003074 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 378806003075 dimer interface [polypeptide binding]; other site 378806003076 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 378806003077 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 378806003078 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806003079 Protein kinase domain; Region: Pkinase; pfam00069 378806003080 active site 378806003081 ATP binding site [chemical binding]; other site 378806003082 substrate binding site [chemical binding]; other site 378806003083 activation loop (A-loop); other site 378806003084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806003085 metabolite-proton symporter; Region: 2A0106; TIGR00883 378806003086 putative substrate translocation pore; other site 378806003087 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 378806003088 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 378806003089 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 378806003090 putative ligand binding site [chemical binding]; other site 378806003091 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 378806003092 TM-ABC transporter signature motif; other site 378806003093 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 378806003094 TM-ABC transporter signature motif; other site 378806003095 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 378806003096 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 378806003097 Walker A/P-loop; other site 378806003098 ATP binding site [chemical binding]; other site 378806003099 Q-loop/lid; other site 378806003100 ABC transporter signature motif; other site 378806003101 Walker B; other site 378806003102 D-loop; other site 378806003103 H-loop/switch region; other site 378806003104 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 378806003105 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 378806003106 Walker A/P-loop; other site 378806003107 ATP binding site [chemical binding]; other site 378806003108 Q-loop/lid; other site 378806003109 ABC transporter signature motif; other site 378806003110 Walker B; other site 378806003111 D-loop; other site 378806003112 H-loop/switch region; other site 378806003113 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806003114 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806003115 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806003116 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 378806003117 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 378806003118 cyclase homology domain; Region: CHD; cd07302 378806003119 nucleotidyl binding site; other site 378806003120 metal binding site [ion binding]; metal-binding site 378806003121 dimer interface [polypeptide binding]; other site 378806003122 prolyl-tRNA synthetase; Provisional; Region: PRK08661 378806003123 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778 378806003124 dimer interface [polypeptide binding]; other site 378806003125 motif 1; other site 378806003126 active site 378806003127 motif 2; other site 378806003128 motif 3; other site 378806003129 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity...; Region: ProRS_anticodon_zinc; cd00862 378806003130 anticodon binding site; other site 378806003131 zinc-binding site [ion binding]; other site 378806003132 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 378806003133 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 378806003134 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 378806003135 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 378806003136 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 378806003137 putative active site [active] 378806003138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806003139 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 378806003140 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 378806003141 malonyl-CoA binding site [chemical binding]; other site 378806003142 dimer interface [polypeptide binding]; other site 378806003143 active site 378806003144 product binding site; other site 378806003145 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 378806003146 acyl-CoA synthetase; Validated; Region: PRK09192 378806003147 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806003148 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806003149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806003150 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 378806003151 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 378806003152 Uncharacterized conserved protein [Function unknown]; Region: COG3410 378806003153 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806003154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806003155 DNA-binding site [nucleotide binding]; DNA binding site 378806003156 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806003157 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 378806003158 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 378806003159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806003160 NAD(P) binding site [chemical binding]; other site 378806003161 active site 378806003162 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 378806003163 FAD binding domain; Region: FAD_binding_4; pfam01565 378806003164 hypothetical protein; Validated; Region: PRK08238 378806003165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806003166 UbiA prenyltransferase family; Region: UbiA; cl00337 378806003167 O-methyltransferase; Region: Methyltransf_2; pfam00891 378806003168 Response regulator receiver domain; Region: Response_reg; pfam00072 378806003169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806003170 active site 378806003171 phosphorylation site [posttranslational modification] 378806003172 intermolecular recognition site; other site 378806003173 dimerization interface [polypeptide binding]; other site 378806003174 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 378806003175 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 378806003176 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 378806003177 catalytic triad [active] 378806003178 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806003179 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806003180 substrate binding site [chemical binding]; other site 378806003181 activation loop (A-loop); other site 378806003182 Predicted ATPase [General function prediction only]; Region: COG3899 378806003183 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 378806003184 GAF domain; Region: GAF; cl00853 378806003185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806003186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003187 ATP binding site [chemical binding]; other site 378806003188 Mg2+ binding site [ion binding]; other site 378806003189 G-X-G motif; other site 378806003190 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806003191 ligand binding site [chemical binding]; other site 378806003192 flexible hinge region; other site 378806003193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806003194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003195 ATP binding site [chemical binding]; other site 378806003196 Mg2+ binding site [ion binding]; other site 378806003197 G-X-G motif; other site 378806003198 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 378806003199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003200 binding surface 378806003201 TPR motif; other site 378806003202 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806003203 ligand binding site [chemical binding]; other site 378806003204 flexible hinge region; other site 378806003205 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806003206 ligand binding site [chemical binding]; other site 378806003207 flexible hinge region; other site 378806003208 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 378806003209 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806003210 ligand binding site [chemical binding]; other site 378806003211 flexible hinge region; other site 378806003212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806003213 putative switch regulator; other site 378806003214 non-specific DNA interactions [nucleotide binding]; other site 378806003215 DNA binding site [nucleotide binding] 378806003216 sequence specific DNA binding site [nucleotide binding]; other site 378806003217 putative cAMP binding site [chemical binding]; other site 378806003218 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 378806003219 ATP binding site [chemical binding]; other site 378806003220 PAS fold; Region: PAS_4; pfam08448 378806003221 putative diguanylate cyclase; Provisional; Region: PRK09776 378806003222 GAF domain; Region: GAF; cl00853 378806003223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806003224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003225 ATP binding site [chemical binding]; other site 378806003226 Mg2+ binding site [ion binding]; other site 378806003227 G-X-G motif; other site 378806003228 Aerotolerance regulator N-terminal; Region: BatA; cl06567 378806003229 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 378806003230 Protein of unknown function DUF58; Region: DUF58; pfam01882 378806003231 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806003232 MoxR-like ATPases [General function prediction only]; Region: COG0714 378806003233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806003234 Walker A motif; other site 378806003235 ATP binding site [chemical binding]; other site 378806003236 Walker B motif; other site 378806003237 arginine finger; other site 378806003238 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 378806003239 PilZ domain; Region: PilZ; cl01260 378806003240 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 378806003241 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 378806003242 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806003243 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 378806003244 active site 378806003245 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806003246 trehalose synthase; Region: treS_nterm; TIGR02456 378806003247 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806003248 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 378806003249 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 378806003250 active site 378806003251 Zn binding site [ion binding]; other site 378806003252 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 378806003253 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 378806003254 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 378806003255 putative active site [active] 378806003256 metal binding site [ion binding]; metal-binding site 378806003257 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806003258 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806003259 metal binding site [ion binding]; metal-binding site 378806003260 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 378806003261 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 378806003262 cofactor binding site; other site 378806003263 metal binding site [ion binding]; metal-binding site 378806003264 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806003265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806003266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 378806003267 dimerization interface [polypeptide binding]; other site 378806003268 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 378806003269 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 378806003270 substrate binding pocket [chemical binding]; other site 378806003271 membrane-bound complex binding site; other site 378806003272 hinge residues; other site 378806003273 Cation efflux family; Region: Cation_efflux; cl00316 378806003274 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 378806003275 intersubunit interface [polypeptide binding]; other site 378806003276 active site 378806003277 Zn2+ binding site [ion binding]; other site 378806003278 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 378806003279 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 378806003280 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 378806003281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 378806003282 muropeptide transporter; Reviewed; Region: ampG; PRK11902 378806003283 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 378806003284 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 378806003285 Walker A/P-loop; other site 378806003286 ATP binding site [chemical binding]; other site 378806003287 Q-loop/lid; other site 378806003288 ABC transporter signature motif; other site 378806003289 Walker B; other site 378806003290 D-loop; other site 378806003291 H-loop/switch region; other site 378806003292 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 378806003293 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 378806003294 Walker A/P-loop; other site 378806003295 ATP binding site [chemical binding]; other site 378806003296 Q-loop/lid; other site 378806003297 ABC transporter signature motif; other site 378806003298 Walker B; other site 378806003299 D-loop; other site 378806003300 H-loop/switch region; other site 378806003301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806003302 dimer interface [polypeptide binding]; other site 378806003303 conserved gate region; other site 378806003304 putative PBP binding loops; other site 378806003305 ABC-ATPase subunit interface; other site 378806003306 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 378806003307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806003308 dimer interface [polypeptide binding]; other site 378806003309 conserved gate region; other site 378806003310 putative PBP binding loops; other site 378806003311 ABC-ATPase subunit interface; other site 378806003312 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 378806003313 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 378806003314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806003315 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806003316 Phage integrase family; Region: Phage_integrase; pfam00589 378806003317 DNA binding site [nucleotide binding] 378806003318 Int/Topo IB signature motif; other site 378806003319 active site 378806003320 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378806003321 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806003322 Protein kinase domain; Region: Pkinase; pfam00069 378806003323 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806003324 active site 378806003325 ATP binding site [chemical binding]; other site 378806003326 substrate binding site [chemical binding]; other site 378806003327 activation loop (A-loop); other site 378806003328 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806003329 active site 378806003330 ATP binding site [chemical binding]; other site 378806003331 substrate binding site [chemical binding]; other site 378806003332 activation loop (A-loop); other site 378806003333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 378806003334 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806003335 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806003336 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806003337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003338 TPR motif; other site 378806003339 binding surface 378806003340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378806003341 dimerization interface [polypeptide binding]; other site 378806003342 putative DNA binding site [nucleotide binding]; other site 378806003343 putative Zn2+ binding site [ion binding]; other site 378806003344 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 378806003345 putative hydrophobic ligand binding site [chemical binding]; other site 378806003346 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806003347 putative catalytic site [active] 378806003348 putative metal binding site [ion binding]; other site 378806003349 putative phosphate binding site [ion binding]; other site 378806003350 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 378806003351 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 378806003352 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806003353 benzoate transport; Region: 2A0115; TIGR00895 378806003354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806003355 putative substrate translocation pore; other site 378806003356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806003357 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 378806003358 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806003359 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 378806003360 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 378806003361 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 378806003362 tetramer interface [polypeptide binding]; other site 378806003363 active site 378806003364 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 378806003365 heterodimer interface [polypeptide binding]; other site 378806003366 active site 378806003367 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 378806003368 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 378806003369 Active site [active] 378806003370 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 378806003371 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 378806003372 dimer interface [polypeptide binding]; other site 378806003373 active site 378806003374 Coenzyme A transferase; Region: CoA_trans; cl00773 378806003375 Coenzyme A transferase; Region: CoA_trans; cl00773 378806003376 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 378806003377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806003378 Bacterial transcriptional regulator; Region: IclR; pfam01614 378806003379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806003380 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 378806003381 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 378806003382 active site 378806003383 FMN binding site [chemical binding]; other site 378806003384 substrate binding site [chemical binding]; other site 378806003385 homotetramer interface [polypeptide binding]; other site 378806003386 catalytic residue [active] 378806003387 Domain of unknown function DUF11; Region: DUF11; cl03172 378806003388 Domain of unknown function DUF11; Region: DUF11; cl03172 378806003389 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 378806003390 DoxX; Region: DoxX; cl00976 378806003391 potential frameshift: common BLAST hit: gi|186685728|ref|YP_001868924.1| multi-sensor hybrid multi-kinase 378806003392 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806003393 substrate binding site [chemical binding]; other site 378806003394 activation loop (A-loop); other site 378806003395 Predicted ATPase [General function prediction only]; Region: COG3899 378806003396 Predicted ATPase [General function prediction only]; Region: COG3899 378806003397 GAF domain; Region: GAF; cl00853 378806003398 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 378806003399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003400 ATP binding site [chemical binding]; other site 378806003401 Mg2+ binding site [ion binding]; other site 378806003402 G-X-G motif; other site 378806003403 Uncharacterized conserved protein [Function unknown]; Region: COG2966 378806003404 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 378806003405 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 378806003406 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 378806003407 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 378806003408 putative catalytic residue [active] 378806003409 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806003410 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806003411 active site 378806003412 catalytic tetrad [active] 378806003413 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 378806003414 active site 378806003415 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806003416 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 378806003417 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 378806003418 active site 378806003419 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806003420 YceI-like domain; Region: YceI; cl01001 378806003421 Uncharacterized conserved protein [Function unknown]; Region: COG5276 378806003422 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806003423 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806003424 active site 378806003425 ATP binding site [chemical binding]; other site 378806003426 substrate binding site [chemical binding]; other site 378806003427 activation loop (A-loop); other site 378806003428 Predicted ATPase [General function prediction only]; Region: COG3899 378806003429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806003430 Walker A motif; other site 378806003431 ATP binding site [chemical binding]; other site 378806003432 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806003433 GAF domain; Region: GAF; cl00853 378806003434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806003435 dimer interface [polypeptide binding]; other site 378806003436 phosphorylation site [posttranslational modification] 378806003437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003438 ATP binding site [chemical binding]; other site 378806003439 Mg2+ binding site [ion binding]; other site 378806003440 G-X-G motif; other site 378806003441 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 378806003442 YcaO-like family; Region: YcaO; cl09146 378806003443 Uncharacterized conserved protein [Function unknown]; Region: COG3482 378806003444 TfuA-like protein; Region: TfuA; pfam07812 378806003445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 378806003446 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 378806003447 catalytic residues [active] 378806003448 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 378806003449 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 378806003450 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 378806003451 substrate binding site [chemical binding]; other site 378806003452 ATP binding site [chemical binding]; other site 378806003453 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 378806003454 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806003455 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 378806003456 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 378806003457 active site 378806003458 Substrate binding site [chemical binding]; other site 378806003459 Mg++ binding site [ion binding]; other site 378806003460 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 378806003461 Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297 378806003462 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806003463 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806003464 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 378806003465 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 378806003466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806003467 inhibitor-cofactor binding pocket; inhibition site 378806003468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806003469 catalytic residue [active] 378806003470 Cupin domain; Region: Cupin_2; cl09118 378806003471 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 378806003472 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 378806003473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806003474 Walker A/P-loop; other site 378806003475 ATP binding site [chemical binding]; other site 378806003476 Q-loop/lid; other site 378806003477 ABC transporter signature motif; other site 378806003478 Walker B; other site 378806003479 D-loop; other site 378806003480 H-loop/switch region; other site 378806003481 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 378806003482 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 378806003483 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 378806003484 Walker A/P-loop; other site 378806003485 ATP binding site [chemical binding]; other site 378806003486 Q-loop/lid; other site 378806003487 ABC transporter signature motif; other site 378806003488 Walker B; other site 378806003489 D-loop; other site 378806003490 H-loop/switch region; other site 378806003491 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 378806003492 active site 378806003493 substrate binding site [chemical binding]; other site 378806003494 ATP binding site [chemical binding]; other site 378806003495 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 378806003496 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 378806003497 NAD(P) binding site [chemical binding]; other site 378806003498 LDH/MDH dimer interface [polypeptide binding]; other site 378806003499 substrate binding site [chemical binding]; other site 378806003500 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 378806003501 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 378806003502 active site 378806003503 NAD binding site [chemical binding]; other site 378806003504 metal binding site [ion binding]; metal-binding site 378806003505 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 378806003506 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 378806003507 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 378806003508 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 378806003509 flavanone-3-hydroxylase; Provisional; Region: PLN03176 378806003510 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 378806003511 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806003512 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 378806003513 putative NAD(P) binding site [chemical binding]; other site 378806003514 homodimer interface [polypeptide binding]; other site 378806003515 homotetramer interface [polypeptide binding]; other site 378806003516 active site 378806003517 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 378806003518 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 378806003519 Surface antigen; Region: Bac_surface_Ag; cl03097 378806003520 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806003521 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806003522 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 378806003523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806003524 PAS fold; Region: PAS_3; pfam08447 378806003525 putative active site [active] 378806003526 heme pocket [chemical binding]; other site 378806003527 PAS domain S-box; Region: sensory_box; TIGR00229 378806003528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806003529 PAS domain S-box; Region: sensory_box; TIGR00229 378806003530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806003531 putative active site [active] 378806003532 heme pocket [chemical binding]; other site 378806003533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806003534 dimer interface [polypeptide binding]; other site 378806003535 phosphorylation site [posttranslational modification] 378806003536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003537 ATP binding site [chemical binding]; other site 378806003538 Mg2+ binding site [ion binding]; other site 378806003539 G-X-G motif; other site 378806003540 Response regulator receiver domain; Region: Response_reg; pfam00072 378806003541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806003542 active site 378806003543 phosphorylation site [posttranslational modification] 378806003544 intermolecular recognition site; other site 378806003545 dimerization interface [polypeptide binding]; other site 378806003546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806003547 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 378806003548 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 378806003549 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 378806003550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003551 binding surface 378806003552 TPR motif; other site 378806003553 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806003554 active site 378806003555 ATP binding site [chemical binding]; other site 378806003556 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806003557 substrate binding site [chemical binding]; other site 378806003558 activation loop (A-loop); other site 378806003559 ribonuclease R; Region: RNase_R; TIGR02063 378806003560 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 378806003561 RNB domain; Region: RNB; pfam00773 378806003562 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 378806003563 RNA binding site [nucleotide binding]; other site 378806003564 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806003565 PhoD-like phosphatase; Region: PhoD; pfam09423 378806003566 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806003567 active site 378806003568 metal binding site [ion binding]; metal-binding site 378806003569 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 378806003570 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 378806003571 6-phosphofructokinase; Provisional; Region: PRK03202 378806003572 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 378806003573 active site 378806003574 ADP/pyrophosphate binding site [chemical binding]; other site 378806003575 dimerization interface [polypeptide binding]; other site 378806003576 allosteric effector site; other site 378806003577 fructose-1,6-bisphosphate binding site; other site 378806003578 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 378806003579 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 378806003580 active site 378806003581 trimer interface [polypeptide binding]; other site 378806003582 allosteric site; other site 378806003583 active site lid [active] 378806003584 hexamer (dimer of trimers) interface [polypeptide binding]; other site 378806003585 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806003586 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806003587 catalytic residue [active] 378806003588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806003589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806003590 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 378806003591 Baseplate J-like protein; Region: Baseplate_J; cl01294 378806003592 Baseplate J-like protein; Region: Baseplate_J; cl01294 378806003593 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 378806003594 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 378806003595 FAD binding domain; Region: FAD_binding_4; pfam01565 378806003596 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378806003597 putative acyl-acceptor binding pocket; other site 378806003598 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 378806003599 putative acyl-acceptor binding pocket; other site 378806003600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806003601 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 378806003602 choline-sulfatase; Region: chol_sulfatase; TIGR03417 378806003603 Sulfatase; Region: Sulfatase; cl10460 378806003604 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 378806003605 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 378806003606 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806003607 Walker A/P-loop; other site 378806003608 ATP binding site [chemical binding]; other site 378806003609 Q-loop/lid; other site 378806003610 ABC transporter signature motif; other site 378806003611 Walker B; other site 378806003612 D-loop; other site 378806003613 H-loop/switch region; other site 378806003614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806003615 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 378806003616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806003617 dimer interface [polypeptide binding]; other site 378806003618 conserved gate region; other site 378806003619 ABC-ATPase subunit interface; other site 378806003620 LysR family transcriptional regulator; Provisional; Region: PRK14997 378806003621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806003622 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 378806003623 putative effector binding pocket; other site 378806003624 dimerization interface [polypeptide binding]; other site 378806003625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806003626 YhhN-like protein; Region: YhhN; cl01505 378806003627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003628 binding surface 378806003629 TPR motif; other site 378806003630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003631 binding surface 378806003632 TPR motif; other site 378806003633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003634 binding surface 378806003635 TPR motif; other site 378806003636 CHAT domain; Region: CHAT; cl02083 378806003637 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 378806003638 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 378806003639 domain; Region: Glyco_hydro_2; pfam00703 378806003640 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 378806003641 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806003642 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806003643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806003644 LysR family transcriptional regulator; Provisional; Region: PRK14997 378806003645 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806003646 dimerization interface [polypeptide binding]; other site 378806003647 Nitronate monooxygenase; Region: NMO; pfam03060 378806003648 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 378806003649 FMN binding site [chemical binding]; other site 378806003650 substrate binding site [chemical binding]; other site 378806003651 putative catalytic residue [active] 378806003652 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 378806003653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806003654 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 378806003655 L-serine binding site [chemical binding]; other site 378806003656 ACT domain interface; other site 378806003657 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806003658 active site 378806003659 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806003660 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806003661 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806003662 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806003663 active site 378806003664 ATP binding site [chemical binding]; other site 378806003665 substrate binding site [chemical binding]; other site 378806003666 activation loop (A-loop); other site 378806003667 Predicted ATPase [General function prediction only]; Region: COG3899 378806003668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003669 TPR motif; other site 378806003670 binding surface 378806003671 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 378806003672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806003673 dimer interface [polypeptide binding]; other site 378806003674 phosphorylation site [posttranslational modification] 378806003675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003676 ATP binding site [chemical binding]; other site 378806003677 Mg2+ binding site [ion binding]; other site 378806003678 G-X-G motif; other site 378806003679 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 378806003680 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 378806003681 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 378806003682 maleylacetoacetate isomerase; Region: maiA; TIGR01262 378806003683 C-terminal domain interface [polypeptide binding]; other site 378806003684 GSH binding site (G-site) [chemical binding]; other site 378806003685 putative dimer interface [polypeptide binding]; other site 378806003686 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 378806003687 dimer interface [polypeptide binding]; other site 378806003688 N-terminal domain interface [polypeptide binding]; other site 378806003689 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 378806003690 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 378806003691 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 378806003692 dimer interface [polypeptide binding]; other site 378806003693 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 378806003694 active site 378806003695 Fe binding site [ion binding]; other site 378806003696 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 378806003697 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 378806003698 putative heme binding site [chemical binding]; other site 378806003699 putative substrate binding site [chemical binding]; other site 378806003700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806003701 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 378806003702 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 378806003703 putative active site [active] 378806003704 catalytic site [active] 378806003705 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 378806003706 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 378806003707 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 378806003708 putative active site [active] 378806003709 putative NTP binding site [chemical binding]; other site 378806003710 putative nucleic acid binding site [nucleotide binding]; other site 378806003711 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 378806003712 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 378806003713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806003714 active site 378806003715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806003716 dimer interface [polypeptide binding]; other site 378806003717 phosphorylation site [posttranslational modification] 378806003718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003719 ATP binding site [chemical binding]; other site 378806003720 Mg2+ binding site [ion binding]; other site 378806003721 G-X-G motif; other site 378806003722 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 378806003723 putative di-iron ligands [ion binding]; other site 378806003724 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 378806003725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806003726 dimer interface [polypeptide binding]; other site 378806003727 phosphorylation site [posttranslational modification] 378806003728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003729 ATP binding site [chemical binding]; other site 378806003730 Mg2+ binding site [ion binding]; other site 378806003731 G-X-G motif; other site 378806003732 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_1_4; cd06241 378806003733 putative active site [active] 378806003734 Zn-binding site [ion binding]; other site 378806003735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806003736 Response regulator receiver domain; Region: Response_reg; pfam00072 378806003737 active site 378806003738 phosphorylation site [posttranslational modification] 378806003739 intermolecular recognition site; other site 378806003740 dimerization interface [polypeptide binding]; other site 378806003741 PAS fold; Region: PAS; pfam00989 378806003742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806003743 putative active site [active] 378806003744 heme pocket [chemical binding]; other site 378806003745 putative diguanylate cyclase; Provisional; Region: PRK09776 378806003746 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 378806003747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806003748 dimer interface [polypeptide binding]; other site 378806003749 phosphorylation site [posttranslational modification] 378806003750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806003751 ATP binding site [chemical binding]; other site 378806003752 Mg2+ binding site [ion binding]; other site 378806003753 G-X-G motif; other site 378806003754 Cupin domain; Region: Cupin_2; cl09118 378806003755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 378806003756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806003757 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 378806003758 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 378806003759 FMN binding site [chemical binding]; other site 378806003760 active site 378806003761 substrate binding site [chemical binding]; other site 378806003762 catalytic residue [active] 378806003763 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 378806003764 putative acyl-acceptor binding pocket; other site 378806003765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806003766 dimer interface [polypeptide binding]; other site 378806003767 conserved gate region; other site 378806003768 putative PBP binding loops; other site 378806003769 ABC-ATPase subunit interface; other site 378806003770 spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187 378806003771 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806003772 Q-loop/lid; other site 378806003773 ABC transporter signature motif; other site 378806003774 Walker B; other site 378806003775 D-loop; other site 378806003776 H-loop/switch region; other site 378806003777 TOBE domain; Region: TOBE_2; cl01440 378806003778 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 378806003779 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 378806003780 Walker A/P-loop; other site 378806003781 ATP binding site [chemical binding]; other site 378806003782 Q-loop/lid; other site 378806003783 ABC transporter signature motif; other site 378806003784 Walker B; other site 378806003785 D-loop; other site 378806003786 H-loop/switch region; other site 378806003787 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 378806003788 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 378806003789 TM-ABC transporter signature motif; other site 378806003790 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 378806003791 TM-ABC transporter signature motif; other site 378806003792 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 378806003793 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 378806003794 putative ligand binding site [chemical binding]; other site 378806003795 CHASE3 domain; Region: CHASE3; cl05000 378806003796 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806003797 dimerization interface [polypeptide binding]; other site 378806003798 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806003799 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806003800 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806003801 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 378806003802 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806003803 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 378806003804 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806003805 MAEBL; Provisional; Region: PTZ00121 378806003806 Protein kinase domain; Region: Pkinase; pfam00069 378806003807 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806003808 active site 378806003809 ATP binding site [chemical binding]; other site 378806003810 substrate binding site [chemical binding]; other site 378806003811 activation loop (A-loop); other site 378806003812 hypothetical protein; Provisional; Region: PRK06834 378806003813 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806003814 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 378806003815 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806003816 putative sugar binding sites [chemical binding]; other site 378806003817 Q-X-W motif; other site 378806003818 classical (c) SDRs; Region: SDR_c; cd05233 378806003819 NAD(P) binding site [chemical binding]; other site 378806003820 active site 378806003821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003822 binding surface 378806003823 TPR motif; other site 378806003824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003825 binding surface 378806003826 TPR motif; other site 378806003827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003828 binding surface 378806003829 TPR motif; other site 378806003830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806003831 binding surface 378806003832 TPR motif; other site 378806003833 CHAT domain; Region: CHAT; cl02083 378806003834 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cd00057 378806003835 sugar binding site [chemical binding]; other site 378806003836 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 378806003837 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806003838 CARDB; Region: CARDB; pfam07705 378806003839 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 378806003840 putative metal binding site [ion binding]; other site 378806003841 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 378806003842 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 378806003843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806003844 putative substrate translocation pore; other site 378806003845 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 378806003846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806003847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806003848 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 378806003849 substrate binding pocket [chemical binding]; other site 378806003850 dimerization interface [polypeptide binding]; other site 378806003851 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 378806003852 NmrA-like family; Region: NmrA; pfam05368 378806003853 putative NADP binding site [chemical binding]; other site 378806003854 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 378806003855 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 378806003856 FMN binding site [chemical binding]; other site 378806003857 active site 378806003858 catalytic residues [active] 378806003859 substrate binding site [chemical binding]; other site 378806003860 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 378806003861 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 378806003862 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 378806003863 Cupin domain; Region: Cupin_2; cl09118 378806003864 Vitamin K epoxide reductase family; Region: VKOR; cl01729 378806003865 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 378806003866 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806003867 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229 378806003868 Amidinotransferase; Region: Amidinotransf; cl12043 378806003869 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 378806003870 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 378806003871 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 378806003872 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 378806003873 metal binding site [ion binding]; metal-binding site 378806003874 ligand binding site [chemical binding]; other site 378806003875 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 378806003876 replication factor C subunit; Provisional; Region: PLN03025 378806003877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806003878 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 378806003879 Walker A motif; other site 378806003880 ATP binding site [chemical binding]; other site 378806003881 Walker B motif; other site 378806003882 arginine finger; other site 378806003883 Baseplate J-like protein; Region: Baseplate_J; cl01294 378806003884 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 378806003885 Uncharacterized conserved protein [Function unknown]; Region: COG4104 378806003886 PAAR motif; Region: PAAR_motif; pfam05488 378806003887 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 378806003888 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 378806003889 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 378806003890 Phage protein D [General function prediction only]; Region: COG3500; cl12180 378806003891 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 378806003892 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 378806003893 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806003894 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806003895 active site 378806003896 catalytic tetrad [active] 378806003897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806003898 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 378806003899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806003900 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 378806003901 substrate binding pocket [chemical binding]; other site 378806003902 dimerization interface [polypeptide binding]; other site 378806003903 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806003904 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806003905 active site 378806003906 short chain dehydrogenase; Provisional; Region: PRK05650 378806003907 classical (c) SDRs; Region: SDR_c; cd05233 378806003908 NAD(P) binding site [chemical binding]; other site 378806003909 active site 378806003910 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 378806003911 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 378806003912 putative active site [active] 378806003913 putative substrate binding site [chemical binding]; other site 378806003914 ATP binding site [chemical binding]; other site 378806003915 Cytochrome P450; Region: p450; cl12078 378806003916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806003917 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 378806003918 EamA-like transporter family; Region: EamA; cl01037 378806003919 EamA-like transporter family; Region: EamA; cl01037 378806003920 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 378806003921 cyclase homology domain; Region: CHD; cd07302 378806003922 nucleotidyl binding site; other site 378806003923 metal binding site [ion binding]; metal-binding site 378806003924 dimer interface [polypeptide binding]; other site 378806003925 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806003926 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 378806003927 MatE; Region: MatE; pfam01554 378806003928 MatE; Region: MatE; pfam01554 378806003929 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806003930 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 378806003931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806003932 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 378806003933 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 378806003934 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806003935 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806003936 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806003937 active site 378806003938 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806003939 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806003940 active site 378806003941 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806003942 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806003943 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 378806003944 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 378806003945 putative NADP binding site [chemical binding]; other site 378806003946 active site 378806003947 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 378806003948 active site 378806003949 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806003950 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806003951 active site 378806003952 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806003953 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806003954 active site 378806003955 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806003956 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806003957 active site 378806003958 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806003959 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806003960 active site 378806003961 PKS_DH; Region: PKS_DH; smart00826 378806003962 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 378806003963 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 378806003964 PKS_DH; Region: PKS_DH; smart00826 378806003965 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 378806003966 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 378806003967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806003968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806003969 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 378806003970 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806003971 inhibitor-cofactor binding pocket; inhibition site 378806003972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806003973 catalytic residue [active] 378806003974 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 378806003975 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806003976 Glutamate binding site [chemical binding]; other site 378806003977 homodimer interface [polypeptide binding]; other site 378806003978 NAD binding site [chemical binding]; other site 378806003979 catalytic residues [active] 378806003980 hypothetical protein; Provisional; Region: PRK06917 378806003981 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806003982 inhibitor-cofactor binding pocket; inhibition site 378806003983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806003984 catalytic residue [active] 378806003985 PilZ domain; Region: PilZ; cl01260 378806003986 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806003987 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 378806003988 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 378806003989 Probable Catalytic site [active] 378806003990 metal binding site [ion binding]; metal-binding site 378806003991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 378806003992 active site 378806003993 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 378806003994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806003995 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806003996 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 378806003997 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 378806003998 Mg++ binding site [ion binding]; other site 378806003999 putative catalytic motif [active] 378806004000 substrate binding site [chemical binding]; other site 378806004001 Predicted peptidase [General function prediction only]; Region: COG4099 378806004002 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 378806004003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806004004 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 378806004005 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 378806004006 O-Antigen ligase; Region: Wzy_C; cl04850 378806004007 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 378806004008 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806004009 Succinylarginine dihydrolase; Region: AstB; cl01511 378806004010 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 378806004011 putative acyl-acceptor binding pocket; other site 378806004012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 378806004013 OstA-like protein; Region: OstA; cl00844 378806004014 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 378806004015 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 378806004016 Walker A/P-loop; other site 378806004017 ATP binding site [chemical binding]; other site 378806004018 Q-loop/lid; other site 378806004019 ABC transporter signature motif; other site 378806004020 Walker B; other site 378806004021 D-loop; other site 378806004022 H-loop/switch region; other site 378806004023 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 378806004024 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 378806004025 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 378806004026 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 378806004027 exopolyphosphatase; Region: exo_poly_only; TIGR03706 378806004028 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 378806004029 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378806004030 short chain dehydrogenase; Provisional; Region: PRK06701 378806004031 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 378806004032 NAD binding site [chemical binding]; other site 378806004033 metal binding site [ion binding]; metal-binding site 378806004034 active site 378806004035 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 378806004036 30S subunit binding site; other site 378806004037 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 378806004038 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 378806004039 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 378806004040 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 378806004041 active site 378806004042 phosphorylation site [posttranslational modification] 378806004043 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 378806004044 putative active site [active] 378806004045 dimerization interface [polypeptide binding]; other site 378806004046 putative tRNAtyr binding site [nucleotide binding]; other site 378806004047 Beta-lactamase; Region: Beta-lactamase; cl01009 378806004048 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 378806004049 dimer interface [polypeptide binding]; other site 378806004050 ssDNA binding site [nucleotide binding]; other site 378806004051 tetramer (dimer of dimers) interface [polypeptide binding]; other site 378806004052 Ion transport protein; Region: Ion_trans; pfam00520 378806004053 Ion channel; Region: Ion_trans_2; cl11596 378806004054 Double zinc ribbon; Region: DZR; pfam12773 378806004055 Cytochrome P450; Region: p450; cl12078 378806004056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806004057 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004058 active site 378806004059 ATP binding site [chemical binding]; other site 378806004060 substrate binding site [chemical binding]; other site 378806004061 activation loop (A-loop); other site 378806004062 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR...; Region: SQR_QFR_TM; cl00881 378806004063 Iron-sulfur protein interface; other site 378806004064 proximal heme binding site [chemical binding]; other site 378806004065 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 378806004066 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 378806004067 dimerization interface [polypeptide binding]; other site 378806004068 domain crossover interface; other site 378806004069 redox-dependent activation switch; other site 378806004070 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806004071 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 378806004072 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 378806004073 G1 box; other site 378806004074 putative GEF interaction site [polypeptide binding]; other site 378806004075 GTP/Mg2+ binding site [chemical binding]; other site 378806004076 Switch I region; other site 378806004077 G2 box; other site 378806004078 G3 box; other site 378806004079 Switch II region; other site 378806004080 G4 box; other site 378806004081 G5 box; other site 378806004082 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696 378806004083 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 378806004084 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 378806004085 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 378806004086 PAS domain S-box; Region: sensory_box; TIGR00229 378806004087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806004088 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 378806004089 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806004090 GAF domain; Region: GAF; cl00853 378806004091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806004092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806004093 dimer interface [polypeptide binding]; other site 378806004094 phosphorylation site [posttranslational modification] 378806004095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806004096 ATP binding site [chemical binding]; other site 378806004097 Mg2+ binding site [ion binding]; other site 378806004098 G-X-G motif; other site 378806004099 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806004100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806004101 active site 378806004102 phosphorylation site [posttranslational modification] 378806004103 intermolecular recognition site; other site 378806004104 dimerization interface [polypeptide binding]; other site 378806004105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806004106 Walker A motif; other site 378806004107 ATP binding site [chemical binding]; other site 378806004108 Walker B motif; other site 378806004109 arginine finger; other site 378806004110 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806004111 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 378806004112 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 378806004113 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 378806004114 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 378806004115 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 378806004116 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 378806004117 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 378806004118 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 378806004119 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 378806004120 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 378806004121 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 378806004122 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 378806004123 SLBB domain; Region: SLBB; pfam10531 378806004124 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 378806004125 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 378806004126 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 378806004127 putative dimer interface [polypeptide binding]; other site 378806004128 [2Fe-2S] cluster binding site [ion binding]; other site 378806004129 Response regulator receiver domain; Region: Response_reg; pfam00072 378806004130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806004131 active site 378806004132 phosphorylation site [posttranslational modification] 378806004133 intermolecular recognition site; other site 378806004134 dimerization interface [polypeptide binding]; other site 378806004135 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 378806004136 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004137 active site 378806004138 ATP binding site [chemical binding]; other site 378806004139 substrate binding site [chemical binding]; other site 378806004140 activation loop (A-loop); other site 378806004141 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806004142 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 378806004143 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 378806004144 putative dimer interface [polypeptide binding]; other site 378806004145 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 378806004146 DNA binding residues [nucleotide binding] 378806004147 Response regulator receiver domain; Region: Response_reg; pfam00072 378806004148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806004149 active site 378806004150 phosphorylation site [posttranslational modification] 378806004151 intermolecular recognition site; other site 378806004152 dimerization interface [polypeptide binding]; other site 378806004153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806004154 NeuB family; Region: NeuB; cl00496 378806004155 CTP synthetase; Validated; Region: pyrG; PRK05380 378806004156 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 378806004157 Catalytic site [active] 378806004158 Active site [active] 378806004159 UTP binding site [chemical binding]; other site 378806004160 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 378806004161 active site 378806004162 putative oxyanion hole; other site 378806004163 catalytic triad [active] 378806004164 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 378806004165 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 378806004166 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 378806004167 Walker A/P-loop; other site 378806004168 ATP binding site [chemical binding]; other site 378806004169 Q-loop/lid; other site 378806004170 ABC transporter signature motif; other site 378806004171 Walker B; other site 378806004172 D-loop; other site 378806004173 H-loop/switch region; other site 378806004174 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806004175 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 378806004176 active site 378806004177 catalytic tetrad [active] 378806004178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806004179 Predicted ATPase [General function prediction only]; Region: COG4637 378806004180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806004181 Walker B; other site 378806004182 D-loop; other site 378806004183 H-loop/switch region; other site 378806004184 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 378806004185 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 378806004186 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004187 active site 378806004188 ATP binding site [chemical binding]; other site 378806004189 substrate binding site [chemical binding]; other site 378806004190 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 378806004191 activation loop (A-loop); other site 378806004192 cyclase homology domain; Region: CHD; cd07302 378806004193 dimer interface [polypeptide binding]; other site 378806004194 nucleotidyl binding site; other site 378806004195 metal binding site [ion binding]; metal-binding site 378806004196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806004197 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806004198 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 378806004199 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 378806004200 YcaO-like family; Region: YcaO; cl09146 378806004201 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 378806004202 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 378806004203 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 378806004204 Ligand binding site [chemical binding]; other site 378806004205 oligomer interface [polypeptide binding]; other site 378806004206 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 378806004207 active site 378806004208 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 378806004209 homodimer interface [polypeptide binding]; other site 378806004210 PAS fold; Region: PAS_3; pfam08447 378806004211 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 378806004212 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806004213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806004214 ATP binding site [chemical binding]; other site 378806004215 Mg2+ binding site [ion binding]; other site 378806004216 G-X-G motif; other site 378806004217 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 378806004218 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 378806004219 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806004220 active site 378806004221 amidophosphoribosyltransferase; Provisional; Region: PRK09123 378806004222 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 378806004223 active site 378806004224 tetramer interface [polypeptide binding]; other site 378806004225 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806004226 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 378806004227 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 378806004228 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 378806004229 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 378806004230 HSP70 interaction site [polypeptide binding]; other site 378806004231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004232 binding surface 378806004233 TPR motif; other site 378806004234 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 378806004235 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 378806004236 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 378806004237 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 378806004238 carboxyltransferase (CT) interaction site; other site 378806004239 biotinylation site [posttranslational modification]; other site 378806004240 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 378806004241 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378806004242 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806004243 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 378806004244 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 378806004245 Protein of unknown function, DUF393; Region: DUF393; cl01136 378806004246 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 378806004247 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806004248 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806004249 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806004250 active site 378806004251 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806004252 PKS_DH; Region: PKS_DH; smart00826 378806004253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806004254 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 378806004255 Enoylreductase; Region: PKS_ER; smart00829 378806004256 NAD(P) binding site [chemical binding]; other site 378806004257 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806004258 putative NADP binding site [chemical binding]; other site 378806004259 active site 378806004260 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806004261 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806004262 FcoT-like thioesterase domain; Region: FcoT; pfam10862 378806004263 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 378806004264 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 378806004265 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 378806004266 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 378806004267 [2Fe-2S] cluster binding site [ion binding]; other site 378806004268 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 378806004269 hydrophobic ligand binding site; other site 378806004270 MAEBL; Provisional; Region: PTZ00121 378806004271 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 378806004272 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 378806004273 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 378806004274 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 378806004275 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 378806004276 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 378806004277 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 378806004278 active site 378806004279 Zn binding site [ion binding]; other site 378806004280 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 378806004281 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806004282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806004283 methionine aminopeptidase; Reviewed; Region: PRK07281 378806004284 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 378806004285 active site 378806004286 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 378806004287 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806004288 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806004289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806004290 DNA-binding site [nucleotide binding]; DNA binding site 378806004291 Cupin domain; Region: Cupin_2; cl09118 378806004292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806004293 S-adenosylmethionine binding site [chemical binding]; other site 378806004294 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 378806004295 Condensation domain; Region: Condensation; cl09290 378806004296 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 378806004297 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806004298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806004299 active site 378806004300 phosphorylation site [posttranslational modification] 378806004301 intermolecular recognition site; other site 378806004302 dimerization interface [polypeptide binding]; other site 378806004303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806004304 ATP binding site [chemical binding]; other site 378806004305 Walker A motif; other site 378806004306 Walker B motif; other site 378806004307 arginine finger; other site 378806004308 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806004309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806004310 dimer interface [polypeptide binding]; other site 378806004311 phosphorylation site [posttranslational modification] 378806004312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806004313 ATP binding site [chemical binding]; other site 378806004314 Mg2+ binding site [ion binding]; other site 378806004315 G-X-G motif; other site 378806004316 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806004317 RDD family; Region: RDD; cl00746 378806004318 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 378806004319 Protein of unknown function (DUF962); Region: DUF962; cl01879 378806004320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806004321 Peptidase family M48; Region: Peptidase_M48; cl12018 378806004322 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 378806004323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806004324 S-adenosylmethionine binding site [chemical binding]; other site 378806004325 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806004326 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806004327 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806004328 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806004329 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806004330 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806004331 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 378806004332 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806004333 HemN C-terminal region; Region: HemN_C; pfam06969 378806004334 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 378806004335 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 378806004336 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 378806004337 PKC phosphorylation site [posttranslational modification]; other site 378806004338 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 378806004339 active site 378806004340 catalytic residues [active] 378806004341 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 378806004342 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806004343 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806004344 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 378806004345 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 378806004346 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 378806004347 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806004348 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 378806004349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004350 binding surface 378806004351 TPR motif; other site 378806004352 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 378806004353 Protein kinase; unclassified specificity; Region: STYKc; smart00221 378806004354 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004355 active site 378806004356 ATP binding site [chemical binding]; other site 378806004357 substrate binding site [chemical binding]; other site 378806004358 activation loop (A-loop); other site 378806004359 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806004360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004361 TPR motif; other site 378806004362 binding surface 378806004363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004364 binding surface 378806004365 TPR motif; other site 378806004366 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 378806004367 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378806004368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806004369 ATP binding site [chemical binding]; other site 378806004370 putative Mg++ binding site [ion binding]; other site 378806004371 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806004372 nucleotide binding region [chemical binding]; other site 378806004373 ATP-binding site [chemical binding]; other site 378806004374 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 378806004375 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 378806004376 putative NAD(P) binding site [chemical binding]; other site 378806004377 dimer interface [polypeptide binding]; other site 378806004378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806004379 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806004380 NAD(P) binding site [chemical binding]; other site 378806004381 active site 378806004382 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806004383 classical (c) SDRs; Region: SDR_c; cd05233 378806004384 NAD(P) binding site [chemical binding]; other site 378806004385 active site 378806004386 H+ Antiporter protein; Region: 2A0121; TIGR00900 378806004387 MOSC domain; Region: MOSC; pfam03473 378806004388 Protein kinase domain; Region: Pkinase; pfam00069 378806004389 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004390 active site 378806004391 ATP binding site [chemical binding]; other site 378806004392 substrate binding site [chemical binding]; other site 378806004393 activation loop (A-loop); other site 378806004394 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378806004395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806004396 Predicted transcriptional regulator [Transcription]; Region: COG2378 378806004397 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 378806004398 Dienelactone hydrolase family; Region: DLH; pfam01738 378806004399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806004400 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 378806004401 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 378806004402 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 378806004403 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 378806004404 domain; Region: Glyco_hydro_2; pfam00703 378806004405 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 378806004406 Immunoglobulin domain; Region: Ig; cl11960 378806004407 Immunoglobulin domain; Region: Ig; cl11960 378806004408 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806004409 sugar binding site [chemical binding]; other site 378806004410 Immunoglobulin domain; Region: Ig; cl11960 378806004411 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806004412 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806004413 Putative cyclase; Region: Cyclase; cl00814 378806004414 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 378806004415 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806004416 Kelch motif; Region: Kelch_1; cl02701 378806004417 Kelch motif; Region: Kelch_1; cl02701 378806004418 Kelch motif; Region: Kelch_1; cl02701 378806004419 Kelch motif; Region: Kelch_1; cl02701 378806004420 Kelch motif; Region: Kelch_1; cl02701 378806004421 Kelch motif; Region: Kelch_1; cl02701 378806004422 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 378806004423 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 378806004424 putative ligand binding site [chemical binding]; other site 378806004425 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 378806004426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806004427 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 378806004428 putative ABC transporter; Region: ycf24; CHL00085 378806004429 FeS assembly ATPase SufC; Region: sufC; TIGR01978 378806004430 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 378806004431 Walker A/P-loop; other site 378806004432 ATP binding site [chemical binding]; other site 378806004433 Q-loop/lid; other site 378806004434 ABC transporter signature motif; other site 378806004435 Walker B; other site 378806004436 D-loop; other site 378806004437 H-loop/switch region; other site 378806004438 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 378806004439 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 378806004440 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 378806004441 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 378806004442 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806004443 catalytic residue [active] 378806004444 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 378806004445 trimerization site [polypeptide binding]; other site 378806004446 active site 378806004447 Domain of unknown function DUF59; Region: DUF59; cl00941 378806004448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806004449 Response regulator receiver domain; Region: Response_reg; pfam00072 378806004450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806004451 active site 378806004452 phosphorylation site [posttranslational modification] 378806004453 intermolecular recognition site; other site 378806004454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806004455 dimerization interface [polypeptide binding]; other site 378806004456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806004457 dimer interface [polypeptide binding]; other site 378806004458 phosphorylation site [posttranslational modification] 378806004459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806004460 ATP binding site [chemical binding]; other site 378806004461 Mg2+ binding site [ion binding]; other site 378806004462 G-X-G motif; other site 378806004463 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 378806004464 proposed catalytic triad [active] 378806004465 conserved cys residue [active] 378806004466 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 378806004467 catalytic nucleophile [active] 378806004468 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806004469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004470 binding surface 378806004471 TPR motif; other site 378806004472 Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969 378806004473 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004474 active site 378806004475 ATP binding site [chemical binding]; other site 378806004476 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806004477 substrate binding site [chemical binding]; other site 378806004478 activation loop (A-loop); other site 378806004479 GAF domain; Region: GAF; cl00853 378806004480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806004481 dimer interface [polypeptide binding]; other site 378806004482 phosphorylation site [posttranslational modification] 378806004483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806004484 ATP binding site [chemical binding]; other site 378806004485 Mg2+ binding site [ion binding]; other site 378806004486 G-X-G motif; other site 378806004487 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806004488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806004489 active site 378806004490 phosphorylation site [posttranslational modification] 378806004491 intermolecular recognition site; other site 378806004492 dimerization interface [polypeptide binding]; other site 378806004493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806004494 Walker A motif; other site 378806004495 ATP binding site [chemical binding]; other site 378806004496 Walker B motif; other site 378806004497 arginine finger; other site 378806004498 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806004499 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806004500 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806004501 glutathione reductase; Validated; Region: PRK06116 378806004502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806004503 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 378806004504 naphthoate synthase; Validated; Region: PRK08321 378806004505 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806004506 substrate binding site [chemical binding]; other site 378806004507 oxyanion hole (OAH) forming residues; other site 378806004508 trimer interface [polypeptide binding]; other site 378806004509 RDD family; Region: RDD; cl00746 378806004510 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 378806004511 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 378806004512 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 378806004513 active site 378806004514 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 378806004515 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806004516 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806004517 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 378806004518 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 378806004519 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 378806004520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806004521 S-adenosylmethionine binding site [chemical binding]; other site 378806004522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806004523 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 378806004524 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806004525 ligand binding site [chemical binding]; other site 378806004526 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 378806004527 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 378806004528 Protein of unknown function (DUF770); Region: DUF770; cl01402 378806004529 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 378806004530 Protein of unknown function (DUF877); Region: DUF877; pfam05943 378806004531 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 378806004532 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 378806004533 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 378806004534 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 378806004535 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 378806004536 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 378806004537 hypothetical protein; Validated; Region: PRK09039 378806004538 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 378806004539 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 378806004540 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 378806004541 active site 378806004542 homotetramer interface [polypeptide binding]; other site 378806004543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806004544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806004545 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806004546 Domain of unknown function (DUF955); Region: DUF955; cl01076 378806004547 HerA helicase [Replication, recombination, and repair]; Region: COG0433 378806004548 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806004549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004550 TPR motif; other site 378806004551 binding surface 378806004552 Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969 378806004553 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 378806004554 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806004555 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 378806004556 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806004557 Sulfatase; Region: Sulfatase; cl10460 378806004558 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 378806004559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806004560 dimer interface [polypeptide binding]; other site 378806004561 phosphorylation site [posttranslational modification] 378806004562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806004563 ATP binding site [chemical binding]; other site 378806004564 G-X-G motif; other site 378806004565 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 378806004566 active site 378806004567 catalytic triad [active] 378806004568 oxyanion hole [active] 378806004569 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 378806004570 Pectinacetylesterase; Region: PAE; pfam03283 378806004571 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 378806004572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 378806004573 superoxide dismutase; Provisional; Region: PRK10543 378806004574 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 378806004575 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 378806004576 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004577 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004578 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004579 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004580 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004581 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004582 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004583 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004584 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004585 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004586 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004587 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004588 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806004589 Pilus assembly protein, PilP; Region: PilP; cl01235 378806004590 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 378806004591 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 378806004592 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 378806004593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806004594 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806004595 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806004596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806004597 DNA-binding site [nucleotide binding]; DNA binding site 378806004598 FCD domain; Region: FCD; cl11656 378806004599 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 378806004600 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 378806004601 valyl-tRNA synthetase; Provisional; Region: valS; PRK14900 378806004602 Domain of unknown function DUF143; Region: DUF143; cl00519 378806004603 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 378806004604 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 378806004605 putative catalytic cysteine [active] 378806004606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004607 TPR motif; other site 378806004608 binding surface 378806004609 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806004610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806004611 active site 378806004612 phosphorylation site [posttranslational modification] 378806004613 intermolecular recognition site; other site 378806004614 dimerization interface [polypeptide binding]; other site 378806004615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806004616 Walker A motif; other site 378806004617 ATP binding site [chemical binding]; other site 378806004618 Walker B motif; other site 378806004619 arginine finger; other site 378806004620 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806004621 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 378806004622 nudix motif; other site 378806004623 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 378806004624 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 378806004625 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806004626 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806004627 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 378806004628 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806004629 motif II; other site 378806004630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806004631 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 378806004632 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 378806004633 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 378806004634 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 378806004635 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 378806004636 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 378806004637 Walker A/P-loop; other site 378806004638 ATP binding site [chemical binding]; other site 378806004639 Q-loop/lid; other site 378806004640 ABC transporter signature motif; other site 378806004641 Walker B; other site 378806004642 D-loop; other site 378806004643 H-loop/switch region; other site 378806004644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 378806004645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 378806004646 substrate binding pocket [chemical binding]; other site 378806004647 membrane-bound complex binding site; other site 378806004648 hinge residues; other site 378806004649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806004650 dimer interface [polypeptide binding]; other site 378806004651 conserved gate region; other site 378806004652 putative PBP binding loops; other site 378806004653 ABC-ATPase subunit interface; other site 378806004654 MbtH-like protein; Region: MbtH; cl01279 378806004655 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 378806004656 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 378806004657 DNA-binding site [nucleotide binding]; DNA binding site 378806004658 RNA-binding motif; other site 378806004659 Cytochrome P450; Region: p450; cl12078 378806004660 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806004661 dimerization interface [polypeptide binding]; other site 378806004662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806004663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806004664 dimer interface [polypeptide binding]; other site 378806004665 phosphorylation site [posttranslational modification] 378806004666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806004667 ATP binding site [chemical binding]; other site 378806004668 Mg2+ binding site [ion binding]; other site 378806004669 G-X-G motif; other site 378806004670 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 378806004671 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 378806004672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806004673 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 378806004674 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 378806004675 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 378806004676 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 378806004677 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 378806004678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806004679 Response regulator receiver domain; Region: Response_reg; pfam00072 378806004680 active site 378806004681 phosphorylation site [posttranslational modification] 378806004682 intermolecular recognition site; other site 378806004683 dimerization interface [polypeptide binding]; other site 378806004684 PAS domain S-box; Region: sensory_box; TIGR00229 378806004685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806004686 putative active site [active] 378806004687 heme pocket [chemical binding]; other site 378806004688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806004689 PAS fold; Region: PAS_3; pfam08447 378806004690 putative active site [active] 378806004691 heme pocket [chemical binding]; other site 378806004692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806004693 PAS domain S-box; Region: sensory_box; TIGR00229 378806004694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806004695 dimer interface [polypeptide binding]; other site 378806004696 phosphorylation site [posttranslational modification] 378806004697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806004698 ATP binding site [chemical binding]; other site 378806004699 Mg2+ binding site [ion binding]; other site 378806004700 G-X-G motif; other site 378806004701 DNA repair protein RadA; Provisional; Region: PRK11823 378806004702 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 378806004703 Walker A motif/ATP binding site; other site 378806004704 ATP binding site [chemical binding]; other site 378806004705 Walker B motif; other site 378806004706 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 378806004707 biotin synthase; Provisional; Region: PRK15108 378806004708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806004709 FeS/SAM binding site; other site 378806004710 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 378806004711 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 378806004712 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 378806004713 substrate-cofactor binding pocket; other site 378806004714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806004715 catalytic residue [active] 378806004716 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806004717 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806004718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806004719 homodimer interface [polypeptide binding]; other site 378806004720 catalytic residue [active] 378806004721 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 378806004722 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 378806004723 ligand binding site [chemical binding]; other site 378806004724 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 378806004725 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 378806004726 active site 378806004727 substrate-binding site [chemical binding]; other site 378806004728 metal-binding site [ion binding] 378806004729 GTP binding site [chemical binding]; other site 378806004730 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 378806004731 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 378806004732 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_5; cd04962 378806004733 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 378806004734 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 378806004735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 378806004736 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 378806004737 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 378806004738 Sodium:solute symporter family; Region: SSF; cl00456 378806004739 Sodium:solute symporter family; Region: SSF; cl00456 378806004740 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 378806004741 active site 378806004742 dinuclear metal binding site [ion binding]; other site 378806004743 dimerization interface [polypeptide binding]; other site 378806004744 Predicted acetyltransferase [General function prediction only]; Region: COG3393 378806004745 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 378806004746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806004747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806004748 PAS domain S-box; Region: sensory_box; TIGR00229 378806004749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806004750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806004751 dimer interface [polypeptide binding]; other site 378806004752 phosphorylation site [posttranslational modification] 378806004753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806004754 ATP binding site [chemical binding]; other site 378806004755 Mg2+ binding site [ion binding]; other site 378806004756 G-X-G motif; other site 378806004757 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806004758 active site 378806004759 HIGH motif; other site 378806004760 nucleotide binding site [chemical binding]; other site 378806004761 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806004762 active site 378806004763 KMSKS motif; other site 378806004764 PEGA domain; Region: PEGA; pfam08308 378806004765 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806004766 active site 378806004767 metal binding site [ion binding]; metal-binding site 378806004768 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 378806004769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806004770 FeS/SAM binding site; other site 378806004771 Chitin binding domain; Region: Chitin_bind_3; cl03871 378806004772 cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; Region: cyclophilin_ABH_like; cd01926 378806004773 active site 378806004774 RNA polymerase sigma factor; Provisional; Region: PRK12513 378806004775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806004776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806004777 DNA binding residues [nucleotide binding] 378806004778 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 378806004779 intersubunit interface [polypeptide binding]; other site 378806004780 active site 378806004781 Zn2+ binding site [ion binding]; other site 378806004782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 378806004783 TM-ABC transporter signature motif; other site 378806004784 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 378806004785 TM-ABC transporter signature motif; other site 378806004786 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 378806004787 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 378806004788 Walker A/P-loop; other site 378806004789 ATP binding site [chemical binding]; other site 378806004790 Q-loop/lid; other site 378806004791 ABC transporter signature motif; other site 378806004792 Walker B; other site 378806004793 D-loop; other site 378806004794 H-loop/switch region; other site 378806004795 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 378806004796 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 378806004797 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 378806004798 putative ligand binding site [chemical binding]; other site 378806004799 L-arabinose isomerase; Provisional; Region: PRK02929 378806004800 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 378806004801 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 378806004802 trimer interface [polypeptide binding]; other site 378806004803 putative substrate binding site [chemical binding]; other site 378806004804 putative metal binding site [ion binding]; other site 378806004805 ribulokinase; Provisional; Region: PRK04123 378806004806 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806004807 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 378806004808 lac repressor; Reviewed; Region: lacI; PRK09526 378806004809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 378806004810 DNA binding site [nucleotide binding] 378806004811 domain linker motif; other site 378806004812 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 378806004813 ligand binding site [chemical binding]; other site 378806004814 dimerization interface (open form) [polypeptide binding]; other site 378806004815 dimerization interface (closed form) [polypeptide binding]; other site 378806004816 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 378806004817 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 378806004818 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 378806004819 active site 378806004820 FMN binding site [chemical binding]; other site 378806004821 substrate binding site [chemical binding]; other site 378806004822 homotetramer interface [polypeptide binding]; other site 378806004823 catalytic residue [active] 378806004824 Protein kinase domain; Region: Pkinase; pfam00069 378806004825 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004826 active site 378806004827 ATP binding site [chemical binding]; other site 378806004828 substrate binding site [chemical binding]; other site 378806004829 activation loop (A-loop); other site 378806004830 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806004831 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 378806004832 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 378806004833 short chain dehydrogenase; Provisional; Region: PRK07060 378806004834 NADP binding site [chemical binding]; other site 378806004835 homodimer interface [polypeptide binding]; other site 378806004836 active site 378806004837 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 378806004838 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 378806004839 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 378806004840 glycogen synthase; Provisional; Region: glgA; PRK00654 378806004841 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 378806004842 ADP-binding pocket [chemical binding]; other site 378806004843 homodimer interface [polypeptide binding]; other site 378806004844 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806004845 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004846 active site 378806004847 ATP binding site [chemical binding]; other site 378806004848 substrate binding site [chemical binding]; other site 378806004849 activation loop (A-loop); other site 378806004850 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806004851 Domain of unknown function DUF21; Region: DUF21; pfam01595 378806004852 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 378806004853 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 378806004854 Transporter associated domain; Region: CorC_HlyC; pfam03471 378806004855 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 378806004856 Late embryogenesis abundant protein; Region: LEA_2; cl12118 378806004857 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806004858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806004859 DNA-binding site [nucleotide binding]; DNA binding site 378806004860 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 378806004861 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 378806004862 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 378806004863 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 378806004864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806004865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806004866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004867 TPR motif; other site 378806004868 binding surface 378806004869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004870 binding surface 378806004871 TPR motif; other site 378806004872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004873 binding surface 378806004874 TPR motif; other site 378806004875 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 378806004876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004877 binding surface 378806004878 TPR motif; other site 378806004879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004880 binding surface 378806004881 TPR motif; other site 378806004882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004883 binding surface 378806004884 TPR motif; other site 378806004885 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 378806004886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004887 TPR motif; other site 378806004888 binding surface 378806004889 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806004890 phosphopeptide binding site; other site 378806004891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806004892 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 378806004893 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004894 active site 378806004895 ATP binding site [chemical binding]; other site 378806004896 substrate binding site [chemical binding]; other site 378806004897 activation loop (A-loop); other site 378806004898 Protein kinase domain; Region: Pkinase; pfam00069 378806004899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004900 active site 378806004901 ATP binding site [chemical binding]; other site 378806004902 substrate binding site [chemical binding]; other site 378806004903 activation loop (A-loop); other site 378806004904 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806004905 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806004906 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806004907 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806004908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806004909 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 378806004910 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 378806004911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806004912 non-specific DNA binding site [nucleotide binding]; other site 378806004913 salt bridge; other site 378806004914 sequence-specific DNA binding site [nucleotide binding]; other site 378806004915 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004916 active site 378806004917 ATP binding site [chemical binding]; other site 378806004918 substrate binding site [chemical binding]; other site 378806004919 activation loop (A-loop); other site 378806004920 chaperone protein HscA; Provisional; Region: hscA; PRK05183 378806004921 Protein kinase domain; Region: Pkinase; pfam00069 378806004922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004923 active site 378806004924 ATP binding site [chemical binding]; other site 378806004925 substrate binding site [chemical binding]; other site 378806004926 activation loop (A-loop); other site 378806004927 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806004928 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378806004929 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806004930 Phage integrase family; Region: Phage_integrase; pfam00589 378806004931 DNA binding site [nucleotide binding] 378806004932 Int/Topo IB signature motif; other site 378806004933 active site 378806004934 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004935 active site 378806004936 substrate binding site [chemical binding]; other site 378806004937 ATP binding site [chemical binding]; other site 378806004938 Protein kinase domain; Region: Pkinase; pfam00069 378806004939 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806004940 substrate binding site [chemical binding]; other site 378806004941 activation loop (A-loop); other site 378806004942 activation loop (A-loop); other site 378806004943 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806004944 active site 378806004945 ATP binding site [chemical binding]; other site 378806004946 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806004947 substrate binding site [chemical binding]; other site 378806004948 activation loop (A-loop); other site 378806004949 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806004950 Phage capsid family; Region: Phage_capsid; pfam05065 378806004951 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806004952 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 378806004953 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806004954 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806004955 Integrase core domain; Region: rve; cl01316 378806004956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806004957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806004958 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 378806004959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806004960 NAD(P) binding site [chemical binding]; other site 378806004961 active site 378806004962 oxidoreductase; Provisional; Region: PRK06196 378806004963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806004964 NAD(P) binding site [chemical binding]; other site 378806004965 active site 378806004966 EamA-like transporter family; Region: EamA; cl01037 378806004967 EamA-like transporter family; Region: EamA; cl01037 378806004968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004969 TPR motif; other site 378806004970 binding surface 378806004971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004972 binding surface 378806004973 TPR motif; other site 378806004974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004975 TPR motif; other site 378806004976 binding surface 378806004977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004978 TPR motif; other site 378806004979 binding surface 378806004980 CHAT domain; Region: CHAT; cl02083 378806004981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806004982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806004983 binding surface 378806004984 TPR motif; other site 378806004985 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806004986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806004987 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 378806004988 Dehydratase family; Region: ILVD_EDD; cl00340 378806004989 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 378806004990 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 378806004991 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806004992 active site 378806004993 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806004994 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 378806004995 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 378806004996 High-affinity nickel-transport protein; Region: NicO; cl00964 378806004997 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378806004998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806004999 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 378806005000 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 378806005001 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 378806005002 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 378806005003 putative substrate binding site [chemical binding]; other site 378806005004 active site 378806005005 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 378806005006 FAD binding domain; Region: FAD_binding_4; pfam01565 378806005007 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 378806005008 Cytochrome P450; Region: p450; cl12078 378806005009 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 378806005010 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 378806005011 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806005012 putative peptidoglycan binding site; other site 378806005013 Domain of unknown function (DUF932); Region: DUF932; cl12129 378806005014 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 378806005015 Putative transposase; Region: Y2_Tnp; pfam04986 378806005016 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 378806005017 dimer interface [polypeptide binding]; other site 378806005018 Transposase domain (DUF772); Region: DUF772; cl12084 378806005019 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 378806005020 putative active site [active] 378806005021 putative metal binding site [ion binding]; other site 378806005022 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806005023 FOG: WD40 repeat [General function prediction only]; Region: COG2319 378806005024 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806005025 structural tetrad; other site 378806005026 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 378806005027 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806005028 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806005029 structural tetrad; other site 378806005030 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806005031 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 378806005032 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 378806005033 metal ion-dependent adhesion site (MIDAS); other site 378806005034 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806005035 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 378806005036 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806005037 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 378806005038 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 378806005039 putative substrate binding site [chemical binding]; other site 378806005040 putative ATP binding site [chemical binding]; other site 378806005041 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 378806005042 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 378806005043 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 378806005044 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 378806005045 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 378806005046 Walker A/P-loop; other site 378806005047 ATP binding site [chemical binding]; other site 378806005048 Q-loop/lid; other site 378806005049 ABC transporter signature motif; other site 378806005050 Walker B; other site 378806005051 D-loop; other site 378806005052 H-loop/switch region; other site 378806005053 TOBE domain; Region: TOBE_2; cl01440 378806005054 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 378806005055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806005056 dimer interface [polypeptide binding]; other site 378806005057 conserved gate region; other site 378806005058 putative PBP binding loops; other site 378806005059 ABC-ATPase subunit interface; other site 378806005060 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 378806005061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806005062 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 378806005063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806005064 active site 378806005065 ATP binding site [chemical binding]; other site 378806005066 substrate binding site [chemical binding]; other site 378806005067 activation loop (A-loop); other site 378806005068 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 378806005069 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 378806005070 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806005071 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 378806005072 FAD binding domain; Region: FAD_binding_4; pfam01565 378806005073 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 378806005074 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 378806005075 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 378806005076 catalytic loop [active] 378806005077 iron binding site [ion binding]; other site 378806005078 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 378806005079 O-methyltransferase; Region: Methyltransf_2; pfam00891 378806005080 Peptidase family M48; Region: Peptidase_M48; cl12018 378806005081 classical (c) SDRs; Region: SDR_c; cd05233 378806005082 active site 378806005083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806005084 dimerization interface [polypeptide binding]; other site 378806005085 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 378806005086 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806005087 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806005088 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 378806005089 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 378806005090 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 378806005091 active site 378806005092 Zn binding site [ion binding]; other site 378806005093 Uncharacterized conserved protein [Function unknown]; Region: COG3268 378806005094 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 378806005095 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 378806005096 dimer interface [polypeptide binding]; other site 378806005097 ADP-ribose binding site [chemical binding]; other site 378806005098 active site 378806005099 nudix motif; other site 378806005100 metal binding site [ion binding]; metal-binding site 378806005101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806005102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806005104 dimerization interface [polypeptide binding]; other site 378806005105 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 378806005106 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 378806005107 dimer interface [polypeptide binding]; other site 378806005108 active site 378806005109 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806005110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806005111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806005112 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 378806005113 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 378806005114 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 378806005115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806005116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005117 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 378806005118 putative substrate binding pocket [chemical binding]; other site 378806005119 putative dimerization interface [polypeptide binding]; other site 378806005120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806005121 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806005122 classical (c) SDRs; Region: SDR_c; cd05233 378806005123 NAD(P) binding site [chemical binding]; other site 378806005124 active site 378806005125 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 378806005126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806005127 active site 378806005128 ATP binding site [chemical binding]; other site 378806005129 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806005130 substrate binding site [chemical binding]; other site 378806005131 activation loop (A-loop); other site 378806005132 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 378806005133 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cd00250 378806005134 active site 378806005135 iron coordination sites [ion binding]; other site 378806005136 substrate binding pocket [chemical binding]; other site 378806005137 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 378806005138 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 378806005139 putative NAD(P) binding site [chemical binding]; other site 378806005140 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 378806005141 Dak1 domain; Region: Dak1; pfam02733 378806005142 DAK2 domain; Region: Dak2; cl03685 378806005143 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 378806005144 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 378806005145 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 378806005146 dimerization domain swap beta strand [polypeptide binding]; other site 378806005147 regulatory protein interface [polypeptide binding]; other site 378806005148 active site 378806005149 regulatory phosphorylation site [posttranslational modification]; other site 378806005150 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 378806005151 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 378806005152 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 378806005153 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 378806005154 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 378806005155 catalytic triad [active] 378806005156 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 378806005157 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806005158 phosphopeptide binding site; other site 378806005159 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806005160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806005161 Walker A motif; other site 378806005162 ATP binding site [chemical binding]; other site 378806005163 Walker B motif; other site 378806005164 arginine finger; other site 378806005165 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 378806005166 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 378806005167 active site 378806005168 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 378806005169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806005170 active site 378806005171 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 378806005172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806005173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378806005174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806005175 active site 378806005176 phosphorylation site [posttranslational modification] 378806005177 intermolecular recognition site; other site 378806005178 dimerization interface [polypeptide binding]; other site 378806005179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806005180 DNA binding site [nucleotide binding] 378806005181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806005182 dimer interface [polypeptide binding]; other site 378806005183 phosphorylation site [posttranslational modification] 378806005184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806005185 ATP binding site [chemical binding]; other site 378806005186 Mg2+ binding site [ion binding]; other site 378806005187 G-X-G motif; other site 378806005188 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 378806005189 Uncharacterized conserved protein [Function unknown]; Region: COG3391 378806005190 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 378806005191 Cupin domain; Region: Cupin_2; cl09118 378806005192 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 378806005193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005194 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 378806005195 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 378806005196 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 378806005197 G1 box; other site 378806005198 GTP/Mg2+ binding site [chemical binding]; other site 378806005199 Switch I region; other site 378806005200 G2 box; other site 378806005201 G3 box; other site 378806005202 Switch II region; other site 378806005203 G4 box; other site 378806005204 G5 box; other site 378806005205 gamma-glutamyl kinase; Provisional; Region: PRK05429 378806005206 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 378806005207 nucleotide binding site [chemical binding]; other site 378806005208 homotetrameric interface [polypeptide binding]; other site 378806005209 putative phosphate binding site [ion binding]; other site 378806005210 putative allosteric binding site; other site 378806005211 PUA domain; Region: PUA; cl00607 378806005212 Predicted transcriptional regulator [Transcription]; Region: COG2378 378806005213 Predicted transcriptional regulator [Transcription]; Region: COG2378 378806005214 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 378806005215 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806005216 phosphopeptide binding site; other site 378806005217 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 378806005218 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 378806005219 putative active site [active] 378806005220 catalytic site [active] 378806005221 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 378806005222 putative active site [active] 378806005223 catalytic site [active] 378806005224 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 378806005225 dinuclear metal binding motif [ion binding]; other site 378806005226 aconitate hydratase; Validated; Region: PRK09277 378806005227 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 378806005228 substrate binding site [chemical binding]; other site 378806005229 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 378806005230 ligand binding site [chemical binding]; other site 378806005231 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 378806005232 substrate binding site [chemical binding]; other site 378806005233 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 378806005234 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 378806005235 RF-1 domain; Region: RF-1; cl02875 378806005236 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 378806005237 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 378806005238 NAD binding site [chemical binding]; other site 378806005239 substrate binding site [chemical binding]; other site 378806005240 catalytic Zn binding site [ion binding]; other site 378806005241 structural Zn binding site [ion binding]; other site 378806005242 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 378806005243 active site 378806005244 catalytic residues [active] 378806005245 metal binding site [ion binding]; metal-binding site 378806005246 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806005247 active site 378806005248 ATP binding site [chemical binding]; other site 378806005249 substrate binding site [chemical binding]; other site 378806005250 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806005251 activation loop (A-loop); other site 378806005252 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806005253 structural tetrad; other site 378806005254 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806005255 structural tetrad; other site 378806005256 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806005257 structural tetrad; other site 378806005258 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 378806005259 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806005260 active site 378806005261 HIGH motif; other site 378806005262 nucleotide binding site [chemical binding]; other site 378806005263 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 378806005264 KMSKS motif; other site 378806005265 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 378806005266 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 378806005267 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 378806005268 P-loop; other site 378806005269 Magnesium ion binding site [ion binding]; other site 378806005270 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 378806005271 Magnesium ion binding site [ion binding]; other site 378806005272 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 378806005273 PilZ domain; Region: PilZ; cl01260 378806005274 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 378806005275 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806005276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806005277 catalytic residue [active] 378806005278 Protein of unknown function (DUF819); Region: DUF819; cl02317 378806005279 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 378806005280 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 378806005281 Walker A/P-loop; other site 378806005282 ATP binding site [chemical binding]; other site 378806005283 Q-loop/lid; other site 378806005284 ABC transporter signature motif; other site 378806005285 Walker B; other site 378806005286 D-loop; other site 378806005287 H-loop/switch region; other site 378806005288 Response regulator receiver domain; Region: Response_reg; pfam00072 378806005289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806005290 active site 378806005291 phosphorylation site [posttranslational modification] 378806005292 intermolecular recognition site; other site 378806005293 dimerization interface [polypeptide binding]; other site 378806005294 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cd01292 378806005295 active site 378806005296 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806005297 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 378806005298 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 378806005299 Substrate binding site [chemical binding]; other site 378806005300 Mg++ binding site [ion binding]; other site 378806005301 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 378806005302 active site 378806005303 substrate binding site [chemical binding]; other site 378806005304 CoA binding site [chemical binding]; other site 378806005305 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 378806005306 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 378806005307 glutaminase active site [active] 378806005308 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 378806005309 dimer interface [polypeptide binding]; other site 378806005310 active site 378806005311 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 378806005312 dimer interface [polypeptide binding]; other site 378806005313 active site 378806005314 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806005315 active site 378806005316 ATP binding site [chemical binding]; other site 378806005317 substrate binding site [chemical binding]; other site 378806005318 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806005319 activation loop (A-loop); other site 378806005320 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 378806005321 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 378806005322 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 378806005323 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806005324 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806005325 recombinase A; Provisional; Region: recA; PRK09354 378806005326 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 378806005327 hexamer interface [polypeptide binding]; other site 378806005328 Walker A motif; other site 378806005329 ATP binding site [chemical binding]; other site 378806005330 Walker B motif; other site 378806005331 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 378806005332 putative active site [active] 378806005333 putative metal binding site [ion binding]; other site 378806005334 PhoD-like phosphatase; Region: PhoD; pfam09423 378806005335 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806005336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806005337 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 378806005338 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 378806005339 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 378806005340 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 378806005341 RNA binding site [nucleotide binding]; other site 378806005342 PAS fold; Region: PAS_4; pfam08448 378806005343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806005344 PAS fold; Region: PAS_3; pfam08447 378806005345 putative active site [active] 378806005346 heme pocket [chemical binding]; other site 378806005347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806005348 dimer interface [polypeptide binding]; other site 378806005349 phosphorylation site [posttranslational modification] 378806005350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806005351 ATP binding site [chemical binding]; other site 378806005352 Mg2+ binding site [ion binding]; other site 378806005353 G-X-G motif; other site 378806005354 HSP90 family protein; Provisional; Region: PRK14083 378806005355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806005356 ATP binding site [chemical binding]; other site 378806005357 Mg2+ binding site [ion binding]; other site 378806005358 G-X-G motif; other site 378806005359 tellurium resistance terB-like protein; Region: terB_like; cl11965 378806005360 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 378806005361 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806005362 NAD(P) binding site [chemical binding]; other site 378806005363 catalytic residues [active] 378806005364 Protein of unknown function (DUF779); Region: DUF779; cl01432 378806005365 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806005366 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 378806005367 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 378806005368 putative active site [active] 378806005369 substrate binding site [chemical binding]; other site 378806005370 putative cosubstrate binding site; other site 378806005371 catalytic site [active] 378806005372 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 378806005373 substrate binding site [chemical binding]; other site 378806005374 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 378806005375 trimer interface [polypeptide binding]; other site 378806005376 active site 378806005377 dimer interface [polypeptide binding]; other site 378806005378 16S rRNA methyltransferase B; Provisional; Region: PRK14902 378806005379 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 378806005380 putative RNA binding site [nucleotide binding]; other site 378806005381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806005382 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 378806005383 iron-sulfur cluster [ion binding]; other site 378806005384 [2Fe-2S] cluster binding site [ion binding]; other site 378806005385 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 378806005386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806005387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 378806005389 dimerization interface [polypeptide binding]; other site 378806005390 conserved hypothetical protein; Region: MJ1255; TIGR00661 378806005391 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 378806005392 active site 378806005393 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 378806005394 Sulfate transporter family; Region: Sulfate_transp; cl00967 378806005395 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 378806005396 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 378806005397 active site clefts [active] 378806005398 zinc binding site [ion binding]; other site 378806005399 dimer interface [polypeptide binding]; other site 378806005400 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 378806005401 putative active site [active] 378806005402 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806005403 active site 378806005404 ATP binding site [chemical binding]; other site 378806005405 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806005406 substrate binding site [chemical binding]; other site 378806005407 activation loop (A-loop); other site 378806005408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806005409 binding surface 378806005410 TPR motif; other site 378806005411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806005412 TPR motif; other site 378806005413 binding surface 378806005414 XPC-binding domain; Region: XPC-binding; pfam09280 378806005415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005416 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 378806005417 NAD(P) binding site [chemical binding]; other site 378806005418 active site 378806005419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806005420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806005421 homodimer interface [polypeptide binding]; other site 378806005422 catalytic residue [active] 378806005423 DNA primase large subunit; Validated; Region: PRK02249 378806005424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005425 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806005426 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806005427 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806005428 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806005429 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806005430 PA14 domain; Region: PA14; cl08459 378806005431 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806005432 dimerization interface [polypeptide binding]; other site 378806005433 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806005434 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806005435 FOG: WD40-like repeat [Function unknown]; Region: COG1520 378806005436 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806005437 classical (c) SDRs; Region: SDR_c; cd05233 378806005438 NAD(P) binding site [chemical binding]; other site 378806005439 active site 378806005440 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806005441 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806005442 active site 378806005443 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 378806005444 active site 378806005445 Zn binding site [ion binding]; other site 378806005446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806005447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806005448 DNA binding residues [nucleotide binding] 378806005449 CHAT domain; Region: CHAT; cl02083 378806005450 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 378806005451 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 378806005452 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 378806005453 putative active site [active] 378806005454 putative substrate binding site [chemical binding]; other site 378806005455 putative cosubstrate binding site; other site 378806005456 catalytic site [active] 378806005457 photolyase PhrII; Region: phr2; TIGR00591 378806005458 DNA photolyase; Region: DNA_photolyase; pfam00875 378806005459 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 378806005460 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806005461 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 378806005462 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 378806005463 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 378806005464 active site 378806005465 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 378806005466 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 378806005467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806005469 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 378806005470 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 378806005471 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 378806005472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005473 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806005474 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806005475 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806005476 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806005477 PA14 domain; Region: PA14; cl08459 378806005478 transcriptional regulator; Provisional; Region: PRK10632 378806005479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005480 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 378806005481 putative effector binding pocket; other site 378806005482 dimerization interface [polypeptide binding]; other site 378806005483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005484 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806005485 active site 378806005486 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806005487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806005488 primosome assembly protein PriA; Validated; Region: PRK05580 378806005489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806005490 ATP binding site [chemical binding]; other site 378806005491 putative Mg++ binding site [ion binding]; other site 378806005492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806005493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806005494 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 378806005495 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 378806005496 dimer interface [polypeptide binding]; other site 378806005497 substrate binding site [chemical binding]; other site 378806005498 metal binding sites [ion binding]; metal-binding site 378806005499 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 378806005500 active site 378806005501 catalytic residues [active] 378806005502 metal binding site [ion binding]; metal-binding site 378806005503 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 378806005504 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 378806005505 tetramer interface [polypeptide binding]; other site 378806005506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806005507 catalytic residue [active] 378806005508 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806005509 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 378806005510 IHF dimer interface [polypeptide binding]; other site 378806005511 IHF - DNA interface [nucleotide binding]; other site 378806005512 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806005513 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 378806005514 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 378806005515 competence damage-inducible protein A; Provisional; Region: PRK00549 378806005516 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 378806005517 putative MPT binding site; other site 378806005518 Competence-damaged protein; Region: CinA; cl00666 378806005519 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 378806005520 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 378806005521 hexamer interface [polypeptide binding]; other site 378806005522 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 378806005523 Walker A motif; other site 378806005524 ATP binding site [chemical binding]; other site 378806005525 Walker B motif; other site 378806005526 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 378806005527 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378806005528 putative acyl-acceptor binding pocket; other site 378806005529 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 378806005530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806005531 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 378806005532 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 378806005533 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806005534 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806005535 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806005536 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 378806005537 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 378806005538 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806005539 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806005540 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806005541 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 378806005542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806005543 FeS/SAM binding site; other site 378806005544 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 378806005545 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 378806005546 THUMP domain; Region: THUMP; cl12076 378806005547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806005548 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 378806005549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806005550 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 378806005551 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806005552 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 378806005553 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 378806005554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806005555 binding surface 378806005556 TPR motif; other site 378806005557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 378806005558 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 378806005559 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 378806005560 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 378806005561 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 378806005562 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 378806005563 GatB domain; Region: GatB_Yqey; cl11497 378806005564 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 378806005565 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 378806005566 Protein kinase domain; Region: Pkinase; pfam00069 378806005567 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806005568 active site 378806005569 ATP binding site [chemical binding]; other site 378806005570 substrate binding site [chemical binding]; other site 378806005571 activation loop (A-loop); other site 378806005572 PilZ domain; Region: PilZ; cl01260 378806005573 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 378806005574 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 378806005575 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 378806005576 GTP1/OBG; Region: GTP1_OBG; pfam01018 378806005577 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 378806005578 G1 box; other site 378806005579 GTP/Mg2+ binding site [chemical binding]; other site 378806005580 Switch I region; other site 378806005581 G2 box; other site 378806005582 G3 box; other site 378806005583 Switch II region; other site 378806005584 G4 box; other site 378806005585 G5 box; other site 378806005586 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 378806005587 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 378806005588 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 378806005589 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806005590 putative catalytic site [active] 378806005591 putative metal binding site [ion binding]; other site 378806005592 putative phosphate binding site [ion binding]; other site 378806005593 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 378806005594 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 378806005595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806005596 FeS/SAM binding site; other site 378806005597 TRAM domain; Region: TRAM; cl01282 378806005598 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 378806005599 Protein of unknown function (DUF520); Region: DUF520; cl00723 378806005600 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 378806005601 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806005602 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 378806005603 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 378806005604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806005605 Walker A motif; other site 378806005606 ATP binding site [chemical binding]; other site 378806005607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806005608 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 378806005609 Walker A motif; other site 378806005610 ATP binding site [chemical binding]; other site 378806005611 Walker B motif; other site 378806005612 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378806005613 peptide chain release factor 2; Region: prfB; TIGR00020 378806005614 RF-1 domain; Region: RF-1; cl02875 378806005615 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 378806005616 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 378806005617 Active_site [active] 378806005618 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 378806005619 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 378806005620 active site 378806005621 metal binding site [ion binding]; metal-binding site 378806005622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806005623 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 378806005624 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 378806005625 CoenzymeA binding site [chemical binding]; other site 378806005626 subunit interaction site [polypeptide binding]; other site 378806005627 PHB binding site; other site 378806005628 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 378806005629 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806005630 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 378806005631 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 378806005632 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 378806005633 active site 378806005634 purine riboside binding site [chemical binding]; other site 378806005635 short chain dehydrogenase; Provisional; Region: PRK07062 378806005636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005637 NAD(P) binding site [chemical binding]; other site 378806005638 active site 378806005639 MltA specific insert domain; Region: MltA; pfam03562 378806005640 3D domain; Region: 3D; cl01439 378806005641 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806005642 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806005643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806005644 dimer interface [polypeptide binding]; other site 378806005645 phosphorylation site [posttranslational modification] 378806005646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806005647 ATP binding site [chemical binding]; other site 378806005648 Mg2+ binding site [ion binding]; other site 378806005649 G-X-G motif; other site 378806005650 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 378806005651 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 378806005652 ligand binding site [chemical binding]; other site 378806005653 oligomer interface [polypeptide binding]; other site 378806005654 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 378806005655 dimer interface [polypeptide binding]; other site 378806005656 N-terminal domain interface [polypeptide binding]; other site 378806005657 sulfate 1 binding site; other site 378806005658 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806005659 phosphopeptide binding site; other site 378806005660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806005661 metal binding site [ion binding]; metal-binding site 378806005662 active site 378806005663 I-site; other site 378806005664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806005665 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 378806005666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005667 NAD(P) binding site [chemical binding]; other site 378806005668 active site 378806005669 fatty acyl-CoA reductase; Region: PLN02996 378806005670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005671 NAD(P) binding site [chemical binding]; other site 378806005672 active site 378806005673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005674 active site 378806005675 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 378806005676 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806005677 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 378806005678 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806005679 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378806005680 putative acyl-acceptor binding pocket; other site 378806005681 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 378806005682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806005683 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 378806005684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005685 NAD(P) binding site [chemical binding]; other site 378806005686 active site 378806005687 SWIB/MDM2 domain; Region: SWIB; cl02489 378806005688 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507 378806005689 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806005690 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 378806005691 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 378806005692 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806005693 Integral membrane protein TerC family; Region: TerC; cl10468 378806005694 Protein of unknown function (DUF525); Region: DUF525; cl01119 378806005695 ferrochelatase; Reviewed; Region: hemH; PRK00035 378806005696 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 378806005697 C-terminal domain interface [polypeptide binding]; other site 378806005698 active site 378806005699 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 378806005700 active site 378806005701 N-terminal domain interface [polypeptide binding]; other site 378806005702 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 378806005703 SUA5 domain; Region: SUA5; pfam03481 378806005704 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 378806005705 putative hydrophobic ligand binding site [chemical binding]; other site 378806005706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005707 TIGR01777 family protein; Region: yfcH 378806005708 NAD(P) binding site [chemical binding]; other site 378806005709 active site 378806005710 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378806005711 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 378806005712 Walker A/P-loop; other site 378806005713 ATP binding site [chemical binding]; other site 378806005714 Q-loop/lid; other site 378806005715 ABC transporter signature motif; other site 378806005716 Walker B; other site 378806005717 D-loop; other site 378806005718 H-loop/switch region; other site 378806005719 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806005720 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 378806005721 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806005722 putative peptidoglycan binding site; other site 378806005723 NlpC/P60 family; Region: NLPC_P60; cl11438 378806005724 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 378806005725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806005726 non-specific DNA binding site [nucleotide binding]; other site 378806005727 salt bridge; other site 378806005728 sequence-specific DNA binding site [nucleotide binding]; other site 378806005729 enterobactin exporter EntS; Provisional; Region: PRK10489 378806005730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806005731 putative substrate translocation pore; other site 378806005732 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 378806005733 Response regulator receiver domain; Region: Response_reg; pfam00072 378806005734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806005735 active site 378806005736 phosphorylation site [posttranslational modification] 378806005737 intermolecular recognition site; other site 378806005738 dimerization interface [polypeptide binding]; other site 378806005739 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806005740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806005741 dimer interface [polypeptide binding]; other site 378806005742 phosphorylation site [posttranslational modification] 378806005743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806005744 ATP binding site [chemical binding]; other site 378806005745 Mg2+ binding site [ion binding]; other site 378806005746 G-X-G motif; other site 378806005747 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 378806005748 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 378806005749 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 378806005750 [2Fe-2S] cluster binding site [ion binding]; other site 378806005751 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 378806005752 endonuclease III; Region: ENDO3c; smart00478 378806005753 minor groove reading motif; other site 378806005754 helix-hairpin-helix signature motif; other site 378806005755 substrate binding pocket [chemical binding]; other site 378806005756 active site 378806005757 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 378806005758 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 378806005759 NAD binding site [chemical binding]; other site 378806005760 catalytic Zn binding site [ion binding]; other site 378806005761 structural Zn binding site [ion binding]; other site 378806005762 muropeptide transporter; Reviewed; Region: ampG; PRK11902 378806005763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 378806005764 hypothetical protein; Provisional; Region: PRK08912 378806005765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806005766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806005767 homodimer interface [polypeptide binding]; other site 378806005768 catalytic residue [active] 378806005769 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 378806005770 Ferritin-like domain; Region: Ferritin; pfam00210 378806005771 dimerization interface [polypeptide binding]; other site 378806005772 DPS ferroxidase diiron center [ion binding]; other site 378806005773 ion pore; other site 378806005774 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 378806005775 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 378806005776 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 378806005777 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 378806005778 dimer interface [polypeptide binding]; other site 378806005779 decamer (pentamer of dimers) interface [polypeptide binding]; other site 378806005780 catalytic triad [active] 378806005781 peroxidatic and resolving cysteines [active] 378806005782 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 378806005783 GAF domain; Region: GAF; cl00853 378806005784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806005785 Walker A motif; other site 378806005786 ATP binding site [chemical binding]; other site 378806005787 Walker B motif; other site 378806005788 arginine finger; other site 378806005789 SdiA-regulated; Region: SdiA-regulated; cl06158 378806005790 putative active site [active] 378806005791 PemK-like protein; Region: PemK; cl00995 378806005792 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806005793 ligand binding site [chemical binding]; other site 378806005794 HYR domain; Region: HYR; pfam02494 378806005795 HYR domain; Region: HYR; pfam02494 378806005796 HYR domain; Region: HYR; pfam02494 378806005797 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 378806005798 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806005799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806005800 catalytic residue [active] 378806005801 cysteine synthases; Region: cysKM; TIGR01136 378806005802 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 378806005803 dimer interface [polypeptide binding]; other site 378806005804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806005805 catalytic residue [active] 378806005806 serine O-acetyltransferase; Region: cysE; TIGR01172 378806005807 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 378806005808 trimer interface [polypeptide binding]; other site 378806005809 active site 378806005810 substrate binding site [chemical binding]; other site 378806005811 CoA binding site [chemical binding]; other site 378806005812 AMP-binding domain protein; Validated; Region: PRK08315 378806005813 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806005814 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 378806005815 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806005816 putative catalytic site [active] 378806005817 putative metal binding site [ion binding]; other site 378806005818 putative phosphate binding site [ion binding]; other site 378806005819 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 378806005820 Intermediate filament tail domain; Region: IF_tail; pfam00932 378806005821 Peptidase family M49; Region: Peptidase_M49; pfam03571 378806005822 Domain of unknown function DUF20; Region: UPF0118; cl00465 378806005823 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 378806005824 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 378806005825 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 378806005826 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 378806005827 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 378806005828 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 378806005829 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806005830 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378806005831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806005832 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 378806005833 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 378806005834 active site 378806005835 uracil binding [chemical binding]; other site 378806005836 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806005837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806005838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806005839 S-adenosylmethionine binding site [chemical binding]; other site 378806005840 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806005841 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 378806005842 putative NAD(P) binding site [chemical binding]; other site 378806005843 active site 378806005844 putative substrate binding site [chemical binding]; other site 378806005845 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 378806005846 putative acyl-acceptor binding pocket; other site 378806005847 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 378806005848 active site 378806005849 metal binding site [ion binding]; metal-binding site 378806005850 alpha-amylase; Region: PLN02361 378806005851 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806005852 Alpha-amylase C-terminal beta-sheet domain; Region: Alpha-amyl_C2; cl06726 378806005853 Domain of unknown function DUF20; Region: UPF0118; cl00465 378806005854 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806005855 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806005856 enoyl-CoA hydratase; Provisional; Region: PRK06563 378806005857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806005858 substrate binding site [chemical binding]; other site 378806005859 oxyanion hole (OAH) forming residues; other site 378806005860 trimer interface [polypeptide binding]; other site 378806005861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005862 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 378806005863 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806005864 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 378806005865 xylose isomerase; Region: PLN02923 378806005866 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 378806005867 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806005868 putative NAD(P) binding site [chemical binding]; other site 378806005869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806005870 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 378806005871 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806005872 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806005873 active site 378806005874 ATP binding site [chemical binding]; other site 378806005875 substrate binding site [chemical binding]; other site 378806005876 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806005877 activation loop (A-loop); other site 378806005878 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806005879 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 378806005880 putative C-terminal domain interface [polypeptide binding]; other site 378806005881 putative GSH binding site (G-site) [chemical binding]; other site 378806005882 putative dimer interface [polypeptide binding]; other site 378806005883 GST_C family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_C_GTT1_like; cd03189 378806005884 putative N-terminal domain interface [polypeptide binding]; other site 378806005885 putative dimer interface [polypeptide binding]; other site 378806005886 putative substrate binding pocket (H-site) [chemical binding]; other site 378806005887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 378806005888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005889 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806005890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005891 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 378806005892 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 378806005893 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 378806005894 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 378806005895 putative NAD(P) binding site [chemical binding]; other site 378806005896 putative substrate binding site [chemical binding]; other site 378806005897 catalytic Zn binding site [ion binding]; other site 378806005898 structural Zn binding site [ion binding]; other site 378806005899 dimer interface [polypeptide binding]; other site 378806005900 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 378806005901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005902 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 378806005903 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806005904 structural tetrad; other site 378806005905 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806005906 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806005907 Integrase core domain; Region: rve; cl01316 378806005908 hypothetical protein; Provisional; Region: PRK06834 378806005909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806005910 GAF domain; Region: GAF; cl00853 378806005911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806005912 dimer interface [polypeptide binding]; other site 378806005913 phosphorylation site [posttranslational modification] 378806005914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806005915 ATP binding site [chemical binding]; other site 378806005916 Mg2+ binding site [ion binding]; other site 378806005917 G-X-G motif; other site 378806005918 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 378806005919 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 378806005920 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806005921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806005922 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 378806005923 putative effector binding pocket; other site 378806005924 putative dimerization interface [polypeptide binding]; other site 378806005925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005926 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 378806005927 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 378806005928 catalytic residues [active] 378806005929 catalytic nucleophile [active] 378806005930 Recombinase; Region: Recombinase; pfam07508 378806005931 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 378806005932 active site 378806005933 NTP binding site [chemical binding]; other site 378806005934 metal binding triad [ion binding]; metal-binding site 378806005935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806005936 ATP binding site [chemical binding]; other site 378806005937 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 378806005938 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 378806005939 putative active site [active] 378806005940 putative catalytic site [active] 378806005941 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 378806005942 putative active site [active] 378806005943 putative catalytic site [active] 378806005944 DNA helicase, putative; Region: TIGR00376 378806005945 Integrase core domain; Region: rve; cl01316 378806005946 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806005947 Transposase domain (DUF772); Region: DUF772; cl12084 378806005948 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806005949 Protein kinase domain; Region: Pkinase; pfam00069 378806005950 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806005951 active site 378806005952 ATP binding site [chemical binding]; other site 378806005953 substrate binding site [chemical binding]; other site 378806005954 activation loop (A-loop); other site 378806005955 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806005956 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806005957 active site 378806005958 ATP binding site [chemical binding]; other site 378806005959 substrate binding site [chemical binding]; other site 378806005960 activation loop (A-loop); other site 378806005961 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806005962 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 378806005963 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 378806005964 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 378806005965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806005966 cofactor binding site; other site 378806005967 DNA binding site [nucleotide binding] 378806005968 substrate interaction site [chemical binding]; other site 378806005969 Z1 domain; Region: Z1; pfam10593 378806005970 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 378806005971 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 378806005972 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806005973 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 378806005974 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806005975 active site 378806005976 ATP binding site [chemical binding]; other site 378806005977 substrate binding site [chemical binding]; other site 378806005978 activation loop (A-loop); other site 378806005979 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 378806005980 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806005981 metal ion-dependent adhesion site (MIDAS); other site 378806005982 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806005983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806005984 Walker A motif; other site 378806005985 ATP binding site [chemical binding]; other site 378806005986 Walker B motif; other site 378806005987 arginine finger; other site 378806005988 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 378806005989 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 378806005990 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 378806005991 catalytic residues [active] 378806005992 catalytic nucleophile [active] 378806005993 Presynaptic Site I dimer interface [polypeptide binding]; other site 378806005994 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 378806005995 Synaptic Flat tetramer interface [polypeptide binding]; other site 378806005996 Synaptic Site I dimer interface [polypeptide binding]; other site 378806005997 DNA binding site [nucleotide binding] 378806005998 Recombinase; Region: Recombinase; pfam07508 378806005999 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806006000 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806006001 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006002 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806006003 active site 378806006004 ATP binding site [chemical binding]; other site 378806006005 substrate binding site [chemical binding]; other site 378806006006 activation loop (A-loop); other site 378806006007 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806006008 Integrase core domain; Region: rve; cl01316 378806006009 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806006010 Transposase domain (DUF772); Region: DUF772; cl12084 378806006011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006012 binding surface 378806006013 TPR motif; other site 378806006014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006015 TPR motif; other site 378806006016 binding surface 378806006017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006018 TPR motif; other site 378806006019 binding surface 378806006020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006021 binding surface 378806006022 TPR motif; other site 378806006023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006024 TPR motif; other site 378806006025 binding surface 378806006026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006027 binding surface 378806006028 TPR motif; other site 378806006029 CHAT domain; Region: CHAT; cl02083 378806006030 TIR domain; Region: TIR; cl02060 378806006031 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806006032 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 378806006033 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 378806006034 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 378806006035 Baseplate J-like protein; Region: Baseplate_J; cl01294 378806006036 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378806006037 DNA binding residues [nucleotide binding] 378806006038 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 378806006039 active site 378806006040 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 378806006041 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 378806006042 Phage protein D [General function prediction only]; Region: COG3500; cl12180 378806006043 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 378806006044 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 378806006045 Protein of unknown function DUF262; Region: DUF262; cl14890 378806006046 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 378806006047 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 378806006048 putative active site [active] 378806006049 putative NTP binding site [chemical binding]; other site 378806006050 putative nucleic acid binding site [nucleotide binding]; other site 378806006051 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 378806006052 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 378806006053 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 378806006054 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 378806006055 Phage capsid family; Region: Phage_capsid; pfam05065 378806006056 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 378806006057 ABC transporter C family member; Provisional; Region: PLN03130 378806006058 Phage-related protein [Function unknown]; Region: COG4695; cl01923 378806006059 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 378806006060 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 378806006061 active site 378806006062 catalytic triad [active] 378806006063 oxyanion hole [active] 378806006064 potential frameshift: common BLAST hit: gi|262194298|ref|YP_003265507.1| protein of unknown function DUF264 378806006065 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 378806006066 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806006067 Phage integrase family; Region: Phage_integrase; pfam00589 378806006068 DNA binding site [nucleotide binding] 378806006069 Int/Topo IB signature motif; other site 378806006070 active site 378806006071 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 378806006072 active site 378806006073 substrate binding site [chemical binding]; other site 378806006074 catalytic site [active] 378806006075 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 378806006076 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378806006077 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806006078 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 378806006079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806006080 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 378806006081 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 378806006082 catalytic residues [active] 378806006083 catalytic nucleophile [active] 378806006084 Presynaptic Site I dimer interface [polypeptide binding]; other site 378806006085 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 378806006086 Synaptic Flat tetramer interface [polypeptide binding]; other site 378806006087 Synaptic Site I dimer interface [polypeptide binding]; other site 378806006088 DNA binding site [nucleotide binding] 378806006089 Recombinase; Region: Recombinase; pfam07508 378806006090 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806006091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006092 active site 378806006093 ATP binding site [chemical binding]; other site 378806006094 substrate binding site [chemical binding]; other site 378806006095 activation loop (A-loop); other site 378806006096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806006097 non-specific DNA binding site [nucleotide binding]; other site 378806006098 salt bridge; other site 378806006099 sequence-specific DNA binding site [nucleotide binding]; other site 378806006100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 378806006101 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006102 active site 378806006103 ATP binding site [chemical binding]; other site 378806006104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806006105 substrate binding site [chemical binding]; other site 378806006106 activation loop (A-loop); other site 378806006107 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806006108 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806006109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806006110 Coenzyme A binding pocket [chemical binding]; other site 378806006111 RDD family; Region: RDD; cl00746 378806006112 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806006113 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806006114 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 378806006115 putative active site pocket [active] 378806006116 dimerization interface [polypeptide binding]; other site 378806006117 putative catalytic residue [active] 378806006118 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 378806006119 putative active site pocket [active] 378806006120 dimerization interface [polypeptide binding]; other site 378806006121 putative catalytic residue [active] 378806006122 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 378806006123 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 378806006124 Baseplate J-like protein; Region: Baseplate_J; cl01294 378806006125 Baseplate J-like protein; Region: Baseplate_J; cl01294 378806006126 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 378806006127 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 378806006128 Phage protein D [General function prediction only]; Region: COG3500; cl12180 378806006129 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 378806006130 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 378806006131 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 378806006132 putative active site [active] 378806006133 putative NTP binding site [chemical binding]; other site 378806006134 putative nucleic acid binding site [nucleotide binding]; other site 378806006135 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 378806006136 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 378806006137 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 378806006138 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 378806006139 Phage capsid family; Region: Phage_capsid; pfam05065 378806006140 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 378806006141 Phage-related protein [Function unknown]; Region: COG4695; cl01923 378806006142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806006143 non-specific DNA binding site [nucleotide binding]; other site 378806006144 salt bridge; other site 378806006145 sequence-specific DNA binding site [nucleotide binding]; other site 378806006146 Domain of unknown function (DUF955); Region: DUF955; cl01076 378806006147 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 378806006148 NADH dehydrogenase; Region: NADHdh; cl00469 378806006149 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 378806006150 large terminase protein; Provisional; Region: 17; PHA02533 378806006151 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806006152 Phage integrase family; Region: Phage_integrase; pfam00589 378806006153 DNA binding site [nucleotide binding] 378806006154 Int/Topo IB signature motif; other site 378806006155 active site 378806006156 putative NHN endonuclease; Region: PHA00280 378806006157 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 378806006158 DNA-binding interface [nucleotide binding]; DNA binding site 378806006159 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 378806006160 active site 378806006161 substrate binding site [chemical binding]; other site 378806006162 catalytic site [active] 378806006163 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 378806006164 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378806006165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806006166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806006167 nucleotide binding region [chemical binding]; other site 378806006168 ATP-binding site [chemical binding]; other site 378806006169 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 378806006170 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 378806006171 catalytic residues [active] 378806006172 catalytic nucleophile [active] 378806006173 Presynaptic Site I dimer interface [polypeptide binding]; other site 378806006174 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 378806006175 Synaptic Flat tetramer interface [polypeptide binding]; other site 378806006176 Synaptic Site I dimer interface [polypeptide binding]; other site 378806006177 DNA binding site [nucleotide binding] 378806006178 Recombinase; Region: Recombinase; pfam07508 378806006179 DNA topoisomerase 2; Provisional; Region: PLN03237 378806006180 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806006181 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006182 active site 378806006183 ATP binding site [chemical binding]; other site 378806006184 substrate binding site [chemical binding]; other site 378806006185 activation loop (A-loop); other site 378806006186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806006187 non-specific DNA binding site [nucleotide binding]; other site 378806006188 salt bridge; other site 378806006189 sequence-specific DNA binding site [nucleotide binding]; other site 378806006190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806006191 non-specific DNA binding site [nucleotide binding]; other site 378806006192 salt bridge; other site 378806006193 sequence-specific DNA binding site [nucleotide binding]; other site 378806006194 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006195 active site 378806006196 ATP binding site [chemical binding]; other site 378806006197 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806006198 substrate binding site [chemical binding]; other site 378806006199 activation loop (A-loop); other site 378806006200 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806006201 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806006202 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 378806006203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806006204 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 378806006205 dimer interface [polypeptide binding]; other site 378806006206 catalytic triad [active] 378806006207 Beta-lactamase; Region: Beta-lactamase; cl01009 378806006208 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 378806006209 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378806006210 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378806006211 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 378806006212 catalytic residues [active] 378806006213 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 378806006214 active site 378806006215 dimerization interface [polypeptide binding]; other site 378806006216 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 378806006217 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 378806006218 SLBB domain; Region: SLBB; pfam10531 378806006219 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 378806006220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006221 binding surface 378806006222 TPR motif; other site 378806006223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006224 TPR motif; other site 378806006225 binding surface 378806006226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 378806006227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 378806006228 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806006229 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 378806006230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006231 binding surface 378806006232 TPR motif; other site 378806006233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 378806006234 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806006235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006236 binding surface 378806006237 TPR motif; other site 378806006238 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 378806006239 G1 box; other site 378806006240 GTP/Mg2+ binding site [chemical binding]; other site 378806006241 G2 box; other site 378806006242 Switch I region; other site 378806006243 G3 box; other site 378806006244 Switch II region; other site 378806006245 G4 box; other site 378806006246 G5 box; other site 378806006247 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 378806006248 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 378806006249 FecR protein; Region: FecR; pfam04773 378806006250 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806006251 active site 378806006252 ATP binding site [chemical binding]; other site 378806006253 substrate binding site [chemical binding]; other site 378806006254 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806006255 activation loop (A-loop); other site 378806006256 recombination protein RecR; Reviewed; Region: recR; PRK00076 378806006257 RecR protein; Region: RecR; pfam02132 378806006258 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 378806006259 putative active site [active] 378806006260 putative metal-binding site [ion binding]; other site 378806006261 tetramer interface [polypeptide binding]; other site 378806006262 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 378806006263 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 378806006264 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 378806006265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806006266 Walker A motif; other site 378806006267 ATP binding site [chemical binding]; other site 378806006268 Walker B motif; other site 378806006269 arginine finger; other site 378806006270 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 378806006271 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 378806006272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806006273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806006274 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; pfam03901 378806006275 mannosyltransferase; Region: PLN02816 378806006276 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 378806006277 nucleoside/Zn binding site; other site 378806006278 dimer interface [polypeptide binding]; other site 378806006279 catalytic motif [active] 378806006280 seryl-tRNA synthetase; Provisional; Region: PRK05431 378806006281 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 378806006282 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 378806006283 dimer interface [polypeptide binding]; other site 378806006284 active site 378806006285 motif 1; other site 378806006286 motif 2; other site 378806006287 motif 3; other site 378806006288 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 378806006289 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806006290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 378806006291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006292 binding surface 378806006293 TPR motif; other site 378806006294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006295 TPR motif; other site 378806006296 binding surface 378806006297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006298 binding surface 378806006299 TPR motif; other site 378806006300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006301 TPR motif; other site 378806006302 binding surface 378806006303 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 378806006304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806006305 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 378806006306 Ligand binding site [chemical binding]; other site 378806006307 Putative Catalytic site [active] 378806006308 DXD motif; other site 378806006309 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 378806006310 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 378806006311 putative acyl-acceptor binding pocket; other site 378806006312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806006313 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 378806006314 putative NAD(P) binding site [chemical binding]; other site 378806006315 active site 378806006316 putative substrate binding site [chemical binding]; other site 378806006317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006318 binding surface 378806006319 TPR motif; other site 378806006320 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 378806006321 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806006322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006323 binding surface 378806006324 TPR motif; other site 378806006325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006326 binding surface 378806006327 TPR motif; other site 378806006328 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378806006329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806006330 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806006331 nucleotide binding region [chemical binding]; other site 378806006332 ATP-binding site [chemical binding]; other site 378806006333 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 378806006334 HRDC domain; Region: HRDC; cl02578 378806006335 hypothetical protein; Reviewed; Region: PRK00024 378806006336 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 378806006337 MPN+ (JAMM) motif; other site 378806006338 Zinc-binding site [ion binding]; other site 378806006339 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 378806006340 NAD-dependent deacetylase; Provisional; Region: PRK05333 378806006341 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 378806006342 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806006343 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 378806006344 NAD binding site [chemical binding]; other site 378806006345 catalytic residues [active] 378806006346 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 378806006347 homotrimer interaction site [polypeptide binding]; other site 378806006348 putative active site [active] 378806006349 Cupin domain; Region: Cupin_2; cl09118 378806006350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806006351 kynureninase; Region: kynureninase; TIGR01814 378806006352 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806006353 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 378806006354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806006355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806006356 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 378806006357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806006358 putative NAD(P) binding site [chemical binding]; other site 378806006359 putative active site [active] 378806006360 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 378806006361 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 378806006362 putative active site [active] 378806006363 catalytic site [active] 378806006364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806006365 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 378806006366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806006367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806006368 ATP-binding site [chemical binding]; other site 378806006369 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806006370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806006371 DNA-binding site [nucleotide binding]; DNA binding site 378806006372 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 378806006373 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 378806006374 putative NAD(P) binding site [chemical binding]; other site 378806006375 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 378806006376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806006377 NAD(P) binding site [chemical binding]; other site 378806006378 active site 378806006379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806006380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806006381 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 378806006382 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 378806006383 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 378806006384 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 378806006385 dimer interface [polypeptide binding]; other site 378806006386 active site 378806006387 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 378806006388 heme binding pocket [chemical binding]; other site 378806006389 Fatty acid desaturase; Region: FA_desaturase; pfam00487 378806006390 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 378806006391 Di-iron ligands [ion binding]; other site 378806006392 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 378806006393 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 378806006394 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 378806006395 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 378806006396 conserved cys residue [active] 378806006397 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 378806006398 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 378806006399 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006400 active site 378806006401 ATP binding site [chemical binding]; other site 378806006402 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806006403 substrate binding site [chemical binding]; other site 378806006404 activation loop (A-loop); other site 378806006405 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 378806006406 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 378806006407 PAS fold; Region: PAS_4; pfam08448 378806006408 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806006409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806006410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806006411 dimer interface [polypeptide binding]; other site 378806006412 phosphorylation site [posttranslational modification] 378806006413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806006414 ATP binding site [chemical binding]; other site 378806006415 Mg2+ binding site [ion binding]; other site 378806006416 G-X-G motif; other site 378806006417 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 378806006418 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 378806006419 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 378806006420 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 378806006421 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806006422 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806006423 acetylornithine and succinylornithine aminotransferases; Region: argD; TIGR00707 378806006424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806006425 catalytic residue [active] 378806006426 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 378806006427 active site 378806006428 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 378806006429 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 378806006430 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 378806006431 dimer interface [polypeptide binding]; other site 378806006432 active site 378806006433 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 378806006434 active site 378806006435 AMP-binding enzyme; Region: AMP-binding; pfam00501 378806006436 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806006437 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806006438 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 378806006439 Fatty acid desaturase; Region: FA_desaturase; pfam00487 378806006440 putative di-iron ligands [ion binding]; other site 378806006441 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806006442 classical (c) SDRs; Region: SDR_c; cd05233 378806006443 NAD(P) binding site [chemical binding]; other site 378806006444 active site 378806006445 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 378806006446 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806006447 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806006448 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806006449 calcium binding site 2 [ion binding]; other site 378806006450 active site 378806006451 catalytic triad [active] 378806006452 calcium binding site 1 [ion binding]; other site 378806006453 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 378806006454 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806006455 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806006456 ligand binding site [chemical binding]; other site 378806006457 flexible hinge region; other site 378806006458 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 378806006459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806006460 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 378806006461 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 378806006462 homodimer interface [polypeptide binding]; other site 378806006463 substrate-cofactor binding pocket; other site 378806006464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806006465 catalytic residue [active] 378806006466 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the...; Region: MoaC; cl00242 378806006467 trimer interface [polypeptide binding]; other site 378806006468 dimer interface [polypeptide binding]; other site 378806006469 putative active site [active] 378806006470 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 378806006471 dimer interface [polypeptide binding]; other site 378806006472 ADP-ribose binding site [chemical binding]; other site 378806006473 active site 378806006474 nudix motif; other site 378806006475 metal binding site [ion binding]; metal-binding site 378806006476 hypothetical protein; Provisional; Region: PRK10941 378806006477 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 378806006478 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 378806006479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806006480 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 378806006481 active site 378806006482 nucleophile elbow; other site 378806006483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378806006484 dimerization interface [polypeptide binding]; other site 378806006485 putative DNA binding site [nucleotide binding]; other site 378806006486 putative Zn2+ binding site [ion binding]; other site 378806006487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806006488 S-adenosylmethionine binding site [chemical binding]; other site 378806006489 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 378806006490 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 378806006491 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 378806006492 substrate binding pocket [chemical binding]; other site 378806006493 dimer interface [polypeptide binding]; other site 378806006494 inhibitor binding site; inhibition site 378806006495 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 378806006496 B12 binding site [chemical binding]; other site 378806006497 cobalt ligand [ion binding]; other site 378806006498 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 378806006499 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 378806006500 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 378806006501 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 378806006502 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 378806006503 minor groove reading motif; other site 378806006504 helix-hairpin-helix signature motif; other site 378806006505 substrate binding pocket [chemical binding]; other site 378806006506 active site 378806006507 FES domain; Region: FES; smart00525 378806006508 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 378806006509 DNA binding and oxoG recognition site [nucleotide binding] 378806006510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806006511 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 378806006512 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 378806006513 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 378806006514 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 378806006515 putative ATP binding site [chemical binding]; other site 378806006516 putative substrate interface [chemical binding]; other site 378806006517 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 378806006518 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 378806006519 active site 378806006520 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 378806006521 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 378806006522 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 378806006523 active site 378806006524 dimer interface [polypeptide binding]; other site 378806006525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006526 binding surface 378806006527 TPR motif; other site 378806006528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 378806006529 TPR motif; other site 378806006530 binding surface 378806006531 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 378806006532 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 378806006533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806006534 S-adenosylmethionine binding site [chemical binding]; other site 378806006535 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 378806006536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806006537 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 378806006538 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 378806006539 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806006540 structural tetrad; other site 378806006541 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806006542 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 378806006543 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806006544 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 378806006545 23S rRNA interface [nucleotide binding]; other site 378806006546 L3 interface [polypeptide binding]; other site 378806006547 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 378806006548 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 378806006549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806006550 ATP binding site [chemical binding]; other site 378806006551 Walker B motif; other site 378806006552 RecX family; Region: RecX; cl00936 378806006553 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 378806006554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006555 binding surface 378806006556 TPR motif; other site 378806006557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806006558 binding surface 378806006559 TPR motif; other site 378806006560 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806006561 phosphopeptide binding site; other site 378806006562 selenophosphate synthetase; Provisional; Region: PRK00943 378806006563 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 378806006564 dimerization interface [polypeptide binding]; other site 378806006565 putative ATP binding site [chemical binding]; other site 378806006566 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 378806006567 active site 378806006568 metal binding site [ion binding]; metal-binding site 378806006569 ribonuclease PH; Reviewed; Region: rph; PRK00173 378806006570 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 378806006571 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 378806006572 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 378806006573 active site 378806006574 dimerization interface [polypeptide binding]; other site 378806006575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806006576 PAS fold; Region: PAS_3; pfam08447 378806006577 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 378806006578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806006579 dimer interface [polypeptide binding]; other site 378806006580 phosphorylation site [posttranslational modification] 378806006581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806006582 ATP binding site [chemical binding]; other site 378806006583 Mg2+ binding site [ion binding]; other site 378806006584 G-X-G motif; other site 378806006585 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 378806006586 heme-binding residues [chemical binding]; other site 378806006587 Ceramidase; Region: Ceramidase; pfam05875 378806006588 RecT family; Region: RecT; cl04285 378806006589 trigger factor; Region: tig; TIGR00115 378806006590 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 378806006591 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 378806006592 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 378806006593 oligomer interface [polypeptide binding]; other site 378806006594 active site residues [active] 378806006595 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 378806006596 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 378806006597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806006598 Walker A motif; other site 378806006599 ATP binding site [chemical binding]; other site 378806006600 Walker B motif; other site 378806006601 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378806006602 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 378806006603 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806006604 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 378806006605 Found in ATP-dependent protease La (LON); Region: LON; cl01056 378806006606 Found in ATP-dependent protease La (LON); Region: LON; cl01056 378806006607 Tat binding protein 1(TBP-1)-interacting protein (TBPIP); Region: TBPIP; pfam07106 378806006608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806006609 Walker A motif; other site 378806006610 ATP binding site [chemical binding]; other site 378806006611 Walker B motif; other site 378806006612 arginine finger; other site 378806006613 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 378806006614 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 378806006615 peptide binding site [polypeptide binding]; other site 378806006616 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 378806006617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 378806006618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806006619 dimer interface [polypeptide binding]; other site 378806006620 conserved gate region; other site 378806006621 putative PBP binding loops; other site 378806006622 ABC-ATPase subunit interface; other site 378806006623 Response regulator receiver domain; Region: Response_reg; pfam00072 378806006624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806006625 active site 378806006626 phosphorylation site [posttranslational modification] 378806006627 intermolecular recognition site; other site 378806006628 dimerization interface [polypeptide binding]; other site 378806006629 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 378806006630 BolA-like protein; Region: BolA; cl00386 378806006631 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 378806006632 putative GSH binding site [chemical binding]; other site 378806006633 catalytic residues [active] 378806006634 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 378806006635 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 378806006636 active site 378806006637 nucleophile elbow; other site 378806006638 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 378806006639 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 378806006640 MOSC domain; Region: MOSC; pfam03473 378806006641 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 378806006642 proline aminopeptidase P II; Provisional; Region: PRK10879 378806006643 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 378806006644 active site 378806006645 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 378806006646 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 378806006647 active site 378806006648 catalytic residues [active] 378806006649 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 378806006650 Phage Tail Collar Domain; Region: Collar; pfam07484 378806006651 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806006652 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806006653 Protein kinase domain; Region: Pkinase; pfam00069 378806006654 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006655 active site 378806006656 ATP binding site [chemical binding]; other site 378806006657 substrate binding site [chemical binding]; other site 378806006658 activation loop (A-loop); other site 378806006659 Protein kinase; unclassified specificity; Region: STYKc; smart00221 378806006660 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006661 active site 378806006662 ATP binding site [chemical binding]; other site 378806006663 substrate binding site [chemical binding]; other site 378806006664 activation loop (A-loop); other site 378806006665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 378806006666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 378806006667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806006668 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806006669 active site 378806006670 catalytic tetrad [active] 378806006671 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806006672 Integrase core domain; Region: rve; cl01316 378806006673 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806006674 potential frameshift: common BLAST hit: gi|51893224|ref|YP_075915.1| transposase 378806006675 Transposase domain (DUF772); Region: DUF772; cl12084 378806006676 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806006677 Chitin binding domain; Region: Chitin_bind_3; cl03871 378806006678 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 378806006679 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 378806006680 Cellulose binding domain; Region: CBM_3; pfam00942 378806006681 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 378806006682 Beta/Gamma crystallin; Region: Crystall; cl02528 378806006683 Beta/Gamma crystallin; Region: Crystall; cl02528 378806006684 DTW domain; Region: DTW; cl01221 378806006685 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 378806006686 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 378806006687 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 378806006688 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806006689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806006690 putative active site [active] 378806006691 heme pocket [chemical binding]; other site 378806006692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806006693 dimer interface [polypeptide binding]; other site 378806006694 phosphorylation site [posttranslational modification] 378806006695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806006696 ATP binding site [chemical binding]; other site 378806006697 G-X-G motif; other site 378806006698 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806006699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806006700 active site 378806006701 phosphorylation site [posttranslational modification] 378806006702 intermolecular recognition site; other site 378806006703 dimerization interface [polypeptide binding]; other site 378806006704 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 378806006705 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 378806006706 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806006707 active site 378806006708 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806006709 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 378806006710 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806006711 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806006712 calcium binding site 2 [ion binding]; other site 378806006713 active site 378806006714 catalytic triad [active] 378806006715 calcium binding site 1 [ion binding]; other site 378806006716 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 378806006717 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 378806006718 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 378806006719 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 378806006720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806006721 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 378806006722 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 378806006723 Beta-lactamase; Region: Beta-lactamase; cl01009 378806006724 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 378806006725 active site clefts [active] 378806006726 zinc binding site [ion binding]; other site 378806006727 dimer interface [polypeptide binding]; other site 378806006728 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 378806006729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 378806006730 substrate binding pocket [chemical binding]; other site 378806006731 membrane-bound complex binding site; other site 378806006732 hinge residues; other site 378806006733 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 378806006734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806006735 dimer interface [polypeptide binding]; other site 378806006736 conserved gate region; other site 378806006737 ABC-ATPase subunit interface; other site 378806006738 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 378806006739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806006740 Walker A/P-loop; other site 378806006741 ATP binding site [chemical binding]; other site 378806006742 Q-loop/lid; other site 378806006743 ABC transporter signature motif; other site 378806006744 Walker B; other site 378806006745 D-loop; other site 378806006746 H-loop/switch region; other site 378806006747 aspartate aminotransferase; Provisional; Region: PRK08361 378806006748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806006749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806006750 homodimer interface [polypeptide binding]; other site 378806006751 catalytic residue [active] 378806006752 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 378806006753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806006754 enoyl-CoA hydratase; Provisional; Region: PRK08259 378806006755 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806006756 substrate binding site [chemical binding]; other site 378806006757 oxyanion hole (OAH) forming residues; other site 378806006758 trimer interface [polypeptide binding]; other site 378806006759 Pectinacetylesterase; Region: PAE; pfam03283 378806006760 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 378806006761 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 378806006762 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 378806006763 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806006764 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006765 active site 378806006766 ATP binding site [chemical binding]; other site 378806006767 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806006768 substrate binding site [chemical binding]; other site 378806006769 activation loop (A-loop); other site 378806006770 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 378806006771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806006772 S-adenosylmethionine binding site [chemical binding]; other site 378806006773 classical (c) SDRs; Region: SDR_c; cd05233 378806006774 NAD(P) binding site [chemical binding]; other site 378806006775 active site 378806006776 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 378806006777 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806006778 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806006779 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 378806006780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806006781 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 378806006782 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 378806006783 metal binding site [ion binding]; metal-binding site 378806006784 putative dimer interface [polypeptide binding]; other site 378806006785 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806006786 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 378806006787 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 378806006788 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 378806006789 metal binding site [ion binding]; metal-binding site 378806006790 putative dimer interface [polypeptide binding]; other site 378806006791 phosphoglucomutase; Validated; Region: PRK07564 378806006792 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 378806006793 active site 378806006794 substrate binding site [chemical binding]; other site 378806006795 metal binding site [ion binding]; metal-binding site 378806006796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806006797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806006798 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 378806006799 putative substrate translocation pore; other site 378806006800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806006801 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 378806006802 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 378806006803 Walker A/P-loop; other site 378806006804 ATP binding site [chemical binding]; other site 378806006805 Q-loop/lid; other site 378806006806 ABC transporter signature motif; other site 378806006807 Walker B; other site 378806006808 D-loop; other site 378806006809 H-loop/switch region; other site 378806006810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806006811 dimer interface [polypeptide binding]; other site 378806006812 conserved gate region; other site 378806006813 putative PBP binding loops; other site 378806006814 ABC-ATPase subunit interface; other site 378806006815 sulfate transport protein; Provisional; Region: cysT; CHL00187 378806006816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806006817 dimer interface [polypeptide binding]; other site 378806006818 conserved gate region; other site 378806006819 putative PBP binding loops; other site 378806006820 ABC-ATPase subunit interface; other site 378806006821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806006822 sulfite reductase subunit beta; Provisional; Region: PRK13504 378806006823 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 378806006824 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 378806006825 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 378806006826 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 378806006827 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 378806006828 FAD binding pocket [chemical binding]; other site 378806006829 FAD binding motif [chemical binding]; other site 378806006830 catalytic residues [active] 378806006831 NAD binding pocket [chemical binding]; other site 378806006832 phosphate binding motif [ion binding]; other site 378806006833 beta-alpha-beta structure motif; other site 378806006834 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 378806006835 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 378806006836 CysD dimerization site [polypeptide binding]; other site 378806006837 G1 box; other site 378806006838 putative GEF interaction site [polypeptide binding]; other site 378806006839 GTP/Mg2+ binding site [chemical binding]; other site 378806006840 Switch I region; other site 378806006841 G2 box; other site 378806006842 G3 box; other site 378806006843 Switch II region; other site 378806006844 G4 box; other site 378806006845 G5 box; other site 378806006846 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 378806006847 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 378806006848 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 378806006849 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 378806006850 Active Sites [active] 378806006851 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 378806006852 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 378806006853 precorrin-2 dehydrogenase; Validated; Region: PRK06719 378806006854 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 378806006855 Active Sites [active] 378806006856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806006857 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806006858 dimerization interface [polypeptide binding]; other site 378806006859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806006860 dimer interface [polypeptide binding]; other site 378806006861 phosphorylation site [posttranslational modification] 378806006862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806006863 ATP binding site [chemical binding]; other site 378806006864 Mg2+ binding site [ion binding]; other site 378806006865 G-X-G motif; other site 378806006866 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 378806006867 GSH binding site [chemical binding]; other site 378806006868 catalytic residues [active] 378806006869 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 378806006870 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 378806006871 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806006872 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 378806006873 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806006874 PAS domain S-box; Region: sensory_box; TIGR00229 378806006875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806006876 putative active site [active] 378806006877 heme pocket [chemical binding]; other site 378806006878 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806006879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806006880 ATP binding site [chemical binding]; other site 378806006881 Mg2+ binding site [ion binding]; other site 378806006882 G-X-G motif; other site 378806006883 Response regulator receiver domain; Region: Response_reg; pfam00072 378806006884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806006885 active site 378806006886 phosphorylation site [posttranslational modification] 378806006887 intermolecular recognition site; other site 378806006888 dimerization interface [polypeptide binding]; other site 378806006889 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806006890 Protein of unknown function (DUF423); Region: DUF423; cl01008 378806006891 SET domain; Region: SET; cl02566 378806006892 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 378806006893 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 378806006894 FtsX-like permease family; Region: FtsX; pfam02687 378806006895 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806006896 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378806006897 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 378806006898 Walker A/P-loop; other site 378806006899 ATP binding site [chemical binding]; other site 378806006900 Q-loop/lid; other site 378806006901 ABC transporter signature motif; other site 378806006902 Walker B; other site 378806006903 D-loop; other site 378806006904 H-loop/switch region; other site 378806006905 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 378806006906 Outer membrane efflux protein; Region: OEP; pfam02321 378806006907 Outer membrane efflux protein; Region: OEP; pfam02321 378806006908 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806006909 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 378806006910 active site 378806006911 metal binding site [ion binding]; metal-binding site 378806006912 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 378806006913 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806006914 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806006915 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 378806006916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806006917 Walker A/P-loop; other site 378806006918 ATP binding site [chemical binding]; other site 378806006919 Q-loop/lid; other site 378806006920 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806006921 ABC transporter signature motif; other site 378806006922 Walker B; other site 378806006923 D-loop; other site 378806006924 H-loop/switch region; other site 378806006925 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806006926 Walker A/P-loop; other site 378806006927 ATP binding site [chemical binding]; other site 378806006928 Q-loop/lid; other site 378806006929 ABC transporter signature motif; other site 378806006930 Walker B; other site 378806006931 D-loop; other site 378806006932 H-loop/switch region; other site 378806006933 excinuclease ABC, A subunit; Region: uvra; TIGR00630 378806006934 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806006935 Walker A/P-loop; other site 378806006936 ATP binding site [chemical binding]; other site 378806006937 Q-loop/lid; other site 378806006938 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 378806006939 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 378806006940 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 378806006941 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 378806006942 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806006943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806006944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806006945 Myxococcus xanthus paralogous family TIGR02265; Region: Mxa_TIGR02265 378806006946 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 378806006947 YcaO-like family; Region: YcaO; cl09146 378806006948 Uncharacterized conserved protein [Function unknown]; Region: COG3482 378806006949 TfuA-like protein; Region: TfuA; pfam07812 378806006950 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 378806006951 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 378806006952 minor groove reading motif; other site 378806006953 helix-hairpin-helix signature motif; other site 378806006954 substrate binding pocket [chemical binding]; other site 378806006955 active site 378806006956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806006957 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 378806006958 substrate binding site [chemical binding]; other site 378806006959 multimerization interface [polypeptide binding]; other site 378806006960 ATP binding site [chemical binding]; other site 378806006961 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 378806006962 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 378806006963 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 378806006964 putative oligopeptide transporter, OPT family; Region: TIGR00733 378806006965 OPT oligopeptide transporter protein; Region: OPT; cl14607 378806006966 Protein kinase domain; Region: Pkinase; pfam00069 378806006967 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006968 active site 378806006969 ATP binding site [chemical binding]; other site 378806006970 substrate binding site [chemical binding]; other site 378806006971 activation loop (A-loop); other site 378806006972 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 378806006973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806006974 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806006975 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806006976 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806006977 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 378806006978 N-terminal domain interface [polypeptide binding]; other site 378806006979 dimer interface [polypeptide binding]; other site 378806006980 substrate binding pocket (H-site) [chemical binding]; other site 378806006981 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 378806006982 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 378806006983 active site 378806006984 catalytic triad [active] 378806006985 dimer interface [polypeptide binding]; other site 378806006986 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806006987 putative catalytic site [active] 378806006988 putative metal binding site [ion binding]; other site 378806006989 putative phosphate binding site [ion binding]; other site 378806006990 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806006991 putative catalytic site [active] 378806006992 putative phosphate binding site [ion binding]; other site 378806006993 putative metal binding site [ion binding]; other site 378806006994 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 378806006995 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806006996 GST_C family, ECM4-like subfamily; composed of predominantly uncharacterized and taxonomically diverse proteins with similarity to the translation product of the Saccharomyces cerevisiae gene ECM4. ECM4, a gene of unknown function, is involved in cell...; Region: GST_C_ECM4_like; cd03190 378806006997 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 378806006998 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806006999 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806007000 active site 378806007001 ATP binding site [chemical binding]; other site 378806007002 substrate binding site [chemical binding]; other site 378806007003 activation loop (A-loop); other site 378806007004 PilZ domain; Region: PilZ; cl01260 378806007005 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 378806007006 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806007007 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806007008 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806007009 ABC transporter; Region: ABC_tran_2; pfam12848 378806007010 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806007011 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 378806007012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806007013 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 378806007014 Walker A/P-loop; other site 378806007015 ATP binding site [chemical binding]; other site 378806007016 Q-loop/lid; other site 378806007017 ABC transporter signature motif; other site 378806007018 Walker B; other site 378806007019 D-loop; other site 378806007020 H-loop/switch region; other site 378806007021 ABC transporter; Region: ABC_tran_2; pfam12848 378806007022 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806007023 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 378806007024 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 378806007025 ATP binding site [chemical binding]; other site 378806007026 Mg++ binding site [ion binding]; other site 378806007027 motif III; other site 378806007028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806007029 nucleotide binding region [chemical binding]; other site 378806007030 ATP-binding site [chemical binding]; other site 378806007031 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 378806007032 elongation factor G; Reviewed; Region: PRK12740 378806007033 G1 box; other site 378806007034 putative GEF interaction site [polypeptide binding]; other site 378806007035 GTP/Mg2+ binding site [chemical binding]; other site 378806007036 Switch I region; other site 378806007037 G2 box; other site 378806007038 G3 box; other site 378806007039 Switch II region; other site 378806007040 G4 box; other site 378806007041 G5 box; other site 378806007042 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 378806007043 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 378806007044 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 378806007045 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806007046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806007047 active site 378806007048 ATP binding site [chemical binding]; other site 378806007049 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806007050 substrate binding site [chemical binding]; other site 378806007051 activation loop (A-loop); other site 378806007052 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 378806007053 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 378806007054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806007055 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806007056 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 378806007057 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 378806007058 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 378806007059 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 378806007060 active site 378806007061 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 378806007062 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 378806007063 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 378806007064 MG2 domain; Region: A2M_N; pfam01835 378806007065 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 378806007066 Alpha-2-macroglobulin family; Region: A2M; pfam00207 378806007067 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 378806007068 surface patch; other site 378806007069 thioester region; other site 378806007070 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 378806007071 Transglycosylase; Region: Transgly; cl07896 378806007072 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 378806007073 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 378806007074 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806007075 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806007076 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806007077 DNA binding residues [nucleotide binding] 378806007078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007079 binding surface 378806007080 TPR motif; other site 378806007081 CotH protein; Region: CotH; pfam08757 378806007082 CHASE3 domain; Region: CHASE3; cl05000 378806007083 GAF domain; Region: GAF; cl00853 378806007084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806007085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806007086 ATP binding site [chemical binding]; other site 378806007087 Mg2+ binding site [ion binding]; other site 378806007088 G-X-G motif; other site 378806007089 Response regulator receiver domain; Region: Response_reg; pfam00072 378806007090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806007091 active site 378806007092 phosphorylation site [posttranslational modification] 378806007093 intermolecular recognition site; other site 378806007094 dimerization interface [polypeptide binding]; other site 378806007095 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806007096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806007097 active site 378806007098 phosphorylation site [posttranslational modification] 378806007099 intermolecular recognition site; other site 378806007100 dimerization interface [polypeptide binding]; other site 378806007101 Response regulator receiver domain; Region: Response_reg; pfam00072 378806007102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806007103 active site 378806007104 phosphorylation site [posttranslational modification] 378806007105 intermolecular recognition site; other site 378806007106 dimerization interface [polypeptide binding]; other site 378806007107 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 378806007108 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 378806007109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806007110 CheB methylesterase; Region: CheB_methylest; pfam01339 378806007111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806007112 active site 378806007113 phosphorylation site [posttranslational modification] 378806007114 intermolecular recognition site; other site 378806007115 dimerization interface [polypeptide binding]; other site 378806007116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806007117 dimer interface [polypeptide binding]; other site 378806007118 phosphorylation site [posttranslational modification] 378806007119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806007120 ATP binding site [chemical binding]; other site 378806007121 Mg2+ binding site [ion binding]; other site 378806007122 G-X-G motif; other site 378806007123 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806007124 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806007125 calcium binding site 2 [ion binding]; other site 378806007126 active site 378806007127 catalytic triad [active] 378806007128 calcium binding site 1 [ion binding]; other site 378806007129 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which...; Region: B_lectin; cd00028 378806007130 dimerization interface [polypeptide binding]; other site 378806007131 mannose binding site [chemical binding]; other site 378806007132 translocation protein TolB; Provisional; Region: tolB; PRK04922 378806007133 Surface antigen; Region: Bac_surface_Ag; cl03097 378806007134 LVIVD repeat; Region: LVIVD; pfam08309 378806007135 Uncharacterized conserved protein [Function unknown]; Region: COG5276 378806007136 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 378806007137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806007138 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 378806007139 active site 378806007140 metal binding site [ion binding]; metal-binding site 378806007141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007142 binding surface 378806007143 TPR motif; other site 378806007144 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 378806007145 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806007146 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 378806007147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806007148 DNA binding residues [nucleotide binding] 378806007149 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 378806007150 type III secretion system protein; Reviewed; Region: PRK06937 378806007151 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 378806007152 Flagellar assembly protein FliH; Region: FliH; pfam02108 378806007153 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 378806007154 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 378806007155 Walker A motif/ATP binding site; other site 378806007156 Walker B motif; other site 378806007157 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 378806007158 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 378806007159 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 378806007160 FliP family; Region: FliP; cl00593 378806007161 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 378806007162 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 378806007163 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 378806007164 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 378806007165 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 378806007166 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 378806007167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007168 TPR motif; other site 378806007169 binding surface 378806007170 Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481 378806007171 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 378806007172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007173 TPR motif; other site 378806007174 binding surface 378806007175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 378806007176 TPR motif; other site 378806007177 binding surface 378806007178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007179 binding surface 378806007180 TPR motif; other site 378806007181 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 378806007182 active site 378806007183 substrate binding site [chemical binding]; other site 378806007184 cosubstrate binding site; other site 378806007185 catalytic site [active] 378806007186 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 378806007187 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 378806007188 FHIPEP family; Region: FHIPEP; pfam00771 378806007189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806007190 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806007191 phosphopeptide binding site; other site 378806007192 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806007193 phosphopeptide binding site; other site 378806007194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007195 TPR motif; other site 378806007196 binding surface 378806007197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007198 binding surface 378806007199 TPR motif; other site 378806007200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007201 binding surface 378806007202 TPR motif; other site 378806007203 RDD family; Region: RDD; cl00746 378806007204 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806007205 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806007206 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806007207 ligand binding site [chemical binding]; other site 378806007208 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806007209 active site 378806007210 metal binding site [ion binding]; metal-binding site 378806007211 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 378806007212 Integral membrane protein DUF95; Region: DUF95; cl00572 378806007213 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 378806007214 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806007215 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 378806007216 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806007217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806007218 catalytic residue [active] 378806007219 DoxX; Region: DoxX; cl00976 378806007220 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 378806007221 active site 378806007222 catalytic triad [active] 378806007223 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 378806007224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 378806007225 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 378806007226 Protein of unknown function (DUF1637); Region: DUF1637; pfam07847 378806007227 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 378806007228 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806007229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806007230 S-adenosylmethionine binding site [chemical binding]; other site 378806007231 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378806007232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806007233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806007234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806007235 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 378806007236 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 378806007237 NADP binding site [chemical binding]; other site 378806007238 dimer interface [polypeptide binding]; other site 378806007239 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 378806007240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806007241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806007242 Mg2+ binding site [ion binding]; other site 378806007243 G-X-G motif; other site 378806007244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378806007245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806007246 active site 378806007247 phosphorylation site [posttranslational modification] 378806007248 intermolecular recognition site; other site 378806007249 dimerization interface [polypeptide binding]; other site 378806007250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806007251 DNA binding site [nucleotide binding] 378806007252 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 378806007253 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 378806007254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806007255 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806007256 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 378806007257 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 378806007258 putative active site [active] 378806007259 putative NTP binding site [chemical binding]; other site 378806007260 putative nucleic acid binding site [nucleotide binding]; other site 378806007261 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806007262 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 378806007263 Cupin domain; Region: Cupin_2; cl09118 378806007264 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 378806007265 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378806007266 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378806007267 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 378806007268 dimer interface [polypeptide binding]; other site 378806007269 catalytic residue [active] 378806007270 potential frameshift: common BLAST hit: gi|108759366|ref|YP_629996.1| GntR family transcriptional regulator 378806007271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806007272 DNA-binding site [nucleotide binding]; DNA binding site 378806007273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806007274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806007275 homodimer interface [polypeptide binding]; other site 378806007276 catalytic residue [active] 378806007277 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 378806007278 Protein of unknown function DUF58; Region: DUF58; pfam01882 378806007279 MoxR-like ATPases [General function prediction only]; Region: COG0714 378806007280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806007281 Walker A motif; other site 378806007282 ATP binding site [chemical binding]; other site 378806007283 Walker B motif; other site 378806007284 arginine finger; other site 378806007285 OsmC-like protein; Region: OsmC; cl00767 378806007286 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 378806007287 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 378806007288 dimerization interface [polypeptide binding]; other site 378806007289 active site 378806007290 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 378806007291 Creatinine amidohydrolase; Region: Creatininase; cl00618 378806007292 Helix-turn-helix domain; Region: HTH_18; pfam12833 378806007293 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806007294 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 378806007295 NlpC/P60 family; Region: NLPC_P60; cl11438 378806007296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806007297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806007298 homodimer interface [polypeptide binding]; other site 378806007299 catalytic residue [active] 378806007300 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 378806007301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806007302 MerC mercury resistance protein; Region: MerC; cl03934 378806007303 Predicted membrane protein [Function unknown]; Region: COG2311 378806007304 Protein of unknown function (DUF418); Region: DUF418; cl12135 378806007305 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806007306 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 378806007307 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 378806007308 NAD(P) binding site [chemical binding]; other site 378806007309 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 378806007310 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806007311 inhibitor-cofactor binding pocket; inhibition site 378806007312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806007313 catalytic residue [active] 378806007314 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 378806007315 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 378806007316 active site 378806007317 homotetramer interface [polypeptide binding]; other site 378806007318 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 378806007319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806007320 NAD(P) binding site [chemical binding]; other site 378806007321 active site 378806007322 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 378806007323 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 378806007324 Metal-binding active site; metal-binding site 378806007325 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 378806007326 active site 378806007327 dimer interface [polypeptide binding]; other site 378806007328 metal binding site [ion binding]; metal-binding site 378806007329 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 378806007330 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 378806007331 active site 378806007332 Substrate binding site [chemical binding]; other site 378806007333 Mg++ binding site [ion binding]; other site 378806007334 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 378806007335 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 378806007336 transcription termination factor Rho; Provisional; Region: PRK12608 378806007337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806007338 Walker A motif; other site 378806007339 ATP binding site [chemical binding]; other site 378806007340 Walker B motif; other site 378806007341 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 378806007342 tandem repeat interface [polypeptide binding]; other site 378806007343 oligomer interface [polypeptide binding]; other site 378806007344 active site residues [active] 378806007345 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 378806007346 tandem repeat interface [polypeptide binding]; other site 378806007347 oligomer interface [polypeptide binding]; other site 378806007348 active site residues [active] 378806007349 PEGA domain; Region: PEGA; pfam08308 378806007350 PEGA domain; Region: PEGA; pfam08308 378806007351 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 378806007352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806007353 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 378806007354 anchoring element; other site 378806007355 dimer interface [polypeptide binding]; other site 378806007356 ATP binding site [chemical binding]; other site 378806007357 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 378806007358 active site 378806007359 putative metal-binding site [ion binding]; other site 378806007360 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 378806007361 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 378806007362 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 378806007363 CAP-like domain; other site 378806007364 Active site [active] 378806007365 primary dimer interface [polypeptide binding]; other site 378806007366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806007367 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806007368 active site 378806007369 ATP binding site [chemical binding]; other site 378806007370 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806007371 substrate binding site [chemical binding]; other site 378806007372 activation loop (A-loop); other site 378806007373 MG2 domain; Region: A2M_N; pfam01835 378806007374 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 378806007375 Alpha-2-macroglobulin family; Region: A2M; pfam00207 378806007376 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 378806007377 surface patch; other site 378806007378 thioester region; other site 378806007379 A-macroglobulin complement component; Region: A2M_comp; pfam07678 378806007380 specificity defining residues; other site 378806007381 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 378806007382 Protein export membrane protein; Region: SecD_SecF; cl14618 378806007383 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 378806007384 Protein export membrane protein; Region: SecD_SecF; cl14618 378806007385 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 378806007386 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 378806007387 Outer membrane efflux protein; Region: OEP; pfam02321 378806007388 Outer membrane efflux protein; Region: OEP; pfam02321 378806007389 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806007390 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806007391 active site 378806007392 metal binding site [ion binding]; metal-binding site 378806007393 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806007394 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806007395 active site 378806007396 catalytic tetrad [active] 378806007397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806007398 dimer interface [polypeptide binding]; other site 378806007399 phosphorylation site [posttranslational modification] 378806007400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806007401 ATP binding site [chemical binding]; other site 378806007402 Mg2+ binding site [ion binding]; other site 378806007403 G-X-G motif; other site 378806007404 Response regulator receiver domain; Region: Response_reg; pfam00072 378806007405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806007406 active site 378806007407 phosphorylation site [posttranslational modification] 378806007408 intermolecular recognition site; other site 378806007409 dimerization interface [polypeptide binding]; other site 378806007410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806007411 dimer interface [polypeptide binding]; other site 378806007412 phosphorylation site [posttranslational modification] 378806007413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806007414 ATP binding site [chemical binding]; other site 378806007415 G-X-G motif; other site 378806007416 Peptidase S46; Region: Peptidase_S46; pfam10459 378806007417 Ycf46; Provisional; Region: ycf46; CHL00195 378806007418 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 378806007419 Beta-lactamase; Region: Beta-lactamase; cl01009 378806007420 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806007421 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 378806007422 active site 378806007423 oxyanion hole [active] 378806007424 catalytic triad [active] 378806007425 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 378806007426 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 378806007427 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 378806007428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 378806007429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806007430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378806007431 putative substrate translocation pore; other site 378806007432 glutathionine S-transferase; Provisional; Region: PRK10542 378806007433 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 378806007434 C-terminal domain interface [polypeptide binding]; other site 378806007435 GSH binding site (G-site) [chemical binding]; other site 378806007436 dimer interface [polypeptide binding]; other site 378806007437 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188 378806007438 dimer interface [polypeptide binding]; other site 378806007439 N-terminal domain interface [polypeptide binding]; other site 378806007440 substrate binding pocket (H-site) [chemical binding]; other site 378806007441 RNA polymerase sigma factor; Provisional; Region: PRK11924 378806007442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806007443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806007444 DNA binding residues [nucleotide binding] 378806007445 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806007446 phosphopeptide binding site; other site 378806007447 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 378806007448 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806007449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806007450 Walker A motif; other site 378806007451 ATP binding site [chemical binding]; other site 378806007452 Walker B motif; other site 378806007453 arginine finger; other site 378806007454 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806007455 General secretion pathway, M protein; Region: GspM; cl01222 378806007456 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 378806007457 GspL cytoplasmic actin-ATPase-like region; Region: GspL; pfam05134 378806007458 General secretion pathway protein K; Region: GspK; pfam03934 378806007459 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 378806007460 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 378806007461 Pseudopilin GspJ; Region: GspJ; pfam11612 378806007462 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 378806007463 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 378806007464 general secretion pathway protein F; Region: GspF; TIGR02120 378806007465 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 378806007466 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 378806007467 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 378806007468 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806007469 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 378806007470 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 378806007471 Walker A motif; other site 378806007472 ATP binding site [chemical binding]; other site 378806007473 Walker B motif; other site 378806007474 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 378806007475 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 378806007476 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 378806007477 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 378806007478 general secretion pathway protein C; Region: typeII_sec_gspC; TIGR01713 378806007479 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806007480 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806007481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806007482 active site 378806007483 phosphorylation site [posttranslational modification] 378806007484 intermolecular recognition site; other site 378806007485 dimerization interface [polypeptide binding]; other site 378806007486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806007487 Walker A motif; other site 378806007488 ATP binding site [chemical binding]; other site 378806007489 Walker B motif; other site 378806007490 arginine finger; other site 378806007491 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806007492 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 378806007493 Erythromycin esterase; Region: Erythro_esteras; pfam05139 378806007494 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 378806007495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806007496 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 378806007497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806007498 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 378806007499 substrate binding pocket [chemical binding]; other site 378806007500 dimerization interface [polypeptide binding]; other site 378806007501 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 378806007502 Cupin domain; Region: Cupin_2; cl09118 378806007503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806007504 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 378806007505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806007506 PAS fold; Region: PAS_3; pfam08447 378806007507 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 378806007508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806007509 putative active site [active] 378806007510 heme pocket [chemical binding]; other site 378806007511 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806007512 GAF domain; Region: GAF; cl00853 378806007513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806007514 dimer interface [polypeptide binding]; other site 378806007515 phosphorylation site [posttranslational modification] 378806007516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806007517 ATP binding site [chemical binding]; other site 378806007518 Mg2+ binding site [ion binding]; other site 378806007519 G-X-G motif; other site 378806007520 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: VWA_YIEM_type; cd01462 378806007521 metal ion-dependent adhesion site (MIDAS); other site 378806007522 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 378806007523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806007524 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 378806007525 Walker A motif; other site 378806007526 ATP binding site [chemical binding]; other site 378806007527 Walker B motif; other site 378806007528 arginine finger; other site 378806007529 SWIM zinc finger; Region: SWIM; cl11618 378806007530 Cupin domain; Region: Cupin_2; cl09118 378806007531 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 378806007532 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 378806007533 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378806007534 Ligand Binding Site [chemical binding]; other site 378806007535 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806007536 active site 378806007537 ATP binding site [chemical binding]; other site 378806007538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806007539 substrate binding site [chemical binding]; other site 378806007540 activation loop (A-loop); other site 378806007541 PEGA domain; Region: PEGA; pfam08308 378806007542 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378806007543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806007544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806007545 putative substrate translocation pore; other site 378806007546 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 378806007547 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806007548 tetrameric interface [polypeptide binding]; other site 378806007549 activator binding site; other site 378806007550 NADP binding site [chemical binding]; other site 378806007551 substrate binding site [chemical binding]; other site 378806007552 catalytic residues [active] 378806007553 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 378806007554 Sulfatase; Region: Sulfatase; cl10460 378806007555 Cupin domain; Region: Cupin_2; cl09118 378806007556 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 378806007557 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806007558 aspartate kinase; Reviewed; Region: PRK06635 378806007559 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 378806007560 putative nucleotide binding site [chemical binding]; other site 378806007561 putative catalytic residues [active] 378806007562 putative Mg ion binding site [ion binding]; other site 378806007563 putative aspartate binding site [chemical binding]; other site 378806007564 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 378806007565 putative allosteric regulatory residue; other site 378806007566 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 378806007567 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806007568 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 378806007569 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 378806007570 catalytic residue [active] 378806007571 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 378806007572 FtsX-like permease family; Region: FtsX; pfam02687 378806007573 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 378806007574 FtsX-like permease family; Region: FtsX; pfam02687 378806007575 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 378806007576 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378806007577 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 378806007578 Walker A/P-loop; other site 378806007579 ATP binding site [chemical binding]; other site 378806007580 Q-loop/lid; other site 378806007581 ABC transporter signature motif; other site 378806007582 Walker B; other site 378806007583 D-loop; other site 378806007584 H-loop/switch region; other site 378806007585 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 378806007586 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806007587 peptide synthase; Provisional; Region: PRK12316 378806007588 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 378806007589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806007590 NAD(P) binding site [chemical binding]; other site 378806007591 active site 378806007592 3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640 378806007593 OPT oligopeptide transporter protein; Region: OPT; cl14607 378806007594 OPT oligopeptide transporter protein; Region: OPT; cl14607 378806007595 ParB-like nuclease domain; Region: ParBc; cl02129 378806007596 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 378806007597 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 378806007598 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 378806007599 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 378806007600 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806007601 phosphopeptide binding site; other site 378806007602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007603 binding surface 378806007604 TPR motif; other site 378806007605 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806007606 ligand binding site [chemical binding]; other site 378806007607 flexible hinge region; other site 378806007608 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806007609 ligand binding site [chemical binding]; other site 378806007610 flexible hinge region; other site 378806007611 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 378806007612 active site 378806007613 catalytic triad [active] 378806007614 oxyanion hole [active] 378806007615 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 378806007616 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 378806007617 Phosphotransferase enzyme family; Region: APH; pfam01636 378806007618 putative active site [active] 378806007619 putative substrate binding site [chemical binding]; other site 378806007620 ATP binding site [chemical binding]; other site 378806007621 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 378806007622 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806007623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007624 TPR motif; other site 378806007625 binding surface 378806007626 PilZ domain; Region: PilZ; cl01260 378806007627 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 378806007628 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 378806007629 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 378806007630 NADP binding site [chemical binding]; other site 378806007631 dimer interface [polypeptide binding]; other site 378806007632 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 378806007633 putative deacylase active site [active] 378806007634 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 378806007635 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806007636 AIR carboxylase; Region: AIRC; cl00310 378806007637 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806007638 metal ion-dependent adhesion site (MIDAS); other site 378806007639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806007640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806007641 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 378806007642 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl02012 378806007643 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 378806007644 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 378806007645 putative active site [active] 378806007646 catalytic triad [active] 378806007647 poly(A) polymerase; Region: pcnB; TIGR01942 378806007648 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 378806007649 active site 378806007650 NTP binding site [chemical binding]; other site 378806007651 metal binding triad [ion binding]; metal-binding site 378806007652 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 378806007653 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 378806007654 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 378806007655 putative active site [active] 378806007656 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 378806007657 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806007658 Walker A/P-loop; other site 378806007659 ATP binding site [chemical binding]; other site 378806007660 Q-loop/lid; other site 378806007661 ABC transporter signature motif; other site 378806007662 Walker B; other site 378806007663 D-loop; other site 378806007664 H-loop/switch region; other site 378806007665 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806007666 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 378806007667 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806007668 Mechanosensitive ion channel; Region: MS_channel; pfam00924 378806007669 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 378806007670 active site 378806007671 DNA polymerase IV; Validated; Region: PRK02406 378806007672 DNA binding site [nucleotide binding] 378806007673 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 378806007674 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 378806007675 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806007676 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 378806007677 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378806007678 RNA binding surface [nucleotide binding]; other site 378806007679 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806007680 active site 378806007681 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806007682 active site 378806007683 ATP binding site [chemical binding]; other site 378806007684 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806007685 substrate binding site [chemical binding]; other site 378806007686 activation loop (A-loop); other site 378806007687 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 378806007688 catalytic residue [active] 378806007689 putative FPP diphosphate binding site; other site 378806007690 putative FPP binding hydrophobic cleft; other site 378806007691 dimer interface [polypeptide binding]; other site 378806007692 putative IPP diphosphate binding site; other site 378806007693 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 378806007694 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 378806007695 active site 378806007696 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 378806007697 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806007698 protein binding site [polypeptide binding]; other site 378806007699 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 378806007700 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 378806007701 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 378806007702 putative substrate binding region [chemical binding]; other site 378806007703 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 378806007704 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 378806007705 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 378806007706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806007707 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 378806007708 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 378806007709 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 378806007710 MoaE interaction surface [polypeptide binding]; other site 378806007711 MoeB interaction surface [polypeptide binding]; other site 378806007712 thiocarboxylated glycine; other site 378806007713 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 378806007714 MoaE homodimer interface [polypeptide binding]; other site 378806007715 MoaD interaction [polypeptide binding]; other site 378806007716 active site residues [active] 378806007717 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 378806007718 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 378806007719 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 378806007720 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 378806007721 putative substrate binding region [chemical binding]; other site 378806007722 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 378806007723 nudix motif; other site 378806007724 acetyl-CoA synthetase; Provisional; Region: PRK00174 378806007725 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 378806007726 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806007727 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 378806007728 Probable Catalytic site [active] 378806007729 metal binding site [ion binding]; metal-binding site 378806007730 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 378806007731 Probable Catalytic site [active] 378806007732 metal binding site [ion binding]; metal-binding site 378806007733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806007734 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806007735 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 378806007736 RNA/DNA hybrid binding site [nucleotide binding]; other site 378806007737 active site 378806007738 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 378806007739 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806007740 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806007741 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 378806007742 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 378806007743 Metal-binding active site; metal-binding site 378806007744 AP (apurinic/apyrimidinic) site pocket; other site 378806007745 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 378806007746 YcaO-like family; Region: YcaO; cl09146 378806007747 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806007748 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378806007749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806007750 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 378806007751 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 378806007752 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 378806007753 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 378806007754 MatE; Region: MatE; pfam01554 378806007755 MatE; Region: MatE; pfam01554 378806007756 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 378806007757 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 378806007758 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806007759 Zn binding site [ion binding]; other site 378806007760 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 378806007761 protein binding site [polypeptide binding]; other site 378806007762 16S rRNA methyltransferase B; Provisional; Region: PRK14902 378806007763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806007764 S-adenosylmethionine binding site [chemical binding]; other site 378806007765 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806007766 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806007767 active site 378806007768 metal binding site [ion binding]; metal-binding site 378806007769 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 378806007770 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 378806007771 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 378806007772 TMP-binding site; other site 378806007773 ATP-binding site [chemical binding]; other site 378806007774 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 378806007775 putative active site; other site 378806007776 putative metal binding residues [ion binding]; other site 378806007777 signature motif; other site 378806007778 putative triphosphate binding site [ion binding]; other site 378806007779 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 378806007780 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806007781 active site 378806007782 ATP binding site [chemical binding]; other site 378806007783 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806007784 substrate binding site [chemical binding]; other site 378806007785 activation loop (A-loop); other site 378806007786 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 378806007787 active site residue [active] 378806007788 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 378806007789 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 378806007790 photoactive yellow protein; Region: photo_yellow; TIGR02373 378806007791 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 378806007792 Substrate-binding site [chemical binding]; other site 378806007793 Substrate specificity [chemical binding]; other site 378806007794 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 378806007795 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 378806007796 putative active site [active] 378806007797 catalytic site [active] 378806007798 putative metal binding site [ion binding]; other site 378806007799 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806007800 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806007801 active site 378806007802 ATP binding site [chemical binding]; other site 378806007803 substrate binding site [chemical binding]; other site 378806007804 activation loop (A-loop); other site 378806007805 Quinolinate synthetase A protein; Region: NadA; cl00420 378806007806 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378806007807 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 378806007808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806007809 S-adenosylmethionine binding site [chemical binding]; other site 378806007810 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806007811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806007812 ATP binding site [chemical binding]; other site 378806007813 Mg2+ binding site [ion binding]; other site 378806007814 G-X-G motif; other site 378806007815 Response regulator receiver domain; Region: Response_reg; pfam00072 378806007816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806007817 active site 378806007818 phosphorylation site [posttranslational modification] 378806007819 intermolecular recognition site; other site 378806007820 dimerization interface [polypeptide binding]; other site 378806007821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806007822 dimer interface [polypeptide binding]; other site 378806007823 phosphorylation site [posttranslational modification] 378806007824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806007825 ATP binding site [chemical binding]; other site 378806007826 Mg2+ binding site [ion binding]; other site 378806007827 G-X-G motif; other site 378806007828 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 378806007829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806007830 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 378806007831 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 378806007832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806007833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 378806007834 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 378806007835 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 378806007836 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 378806007837 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 378806007838 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 378806007839 EamA-like transporter family; Region: EamA; cl01037 378806007840 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806007841 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806007842 active site 378806007843 metal binding site [ion binding]; metal-binding site 378806007844 FOG: CBS domain [General function prediction only]; Region: COG0517 378806007845 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 378806007846 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 378806007847 active site 378806007848 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 378806007849 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 378806007850 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 378806007851 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 378806007852 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 378806007853 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806007854 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806007855 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 378806007856 adenylosuccinate synthetase; Provisional; Region: PRK01117 378806007857 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 378806007858 GDP-binding site [chemical binding]; other site 378806007859 ACT binding site; other site 378806007860 IMP binding site; other site 378806007861 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806007862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007863 binding surface 378806007864 TPR motif; other site 378806007865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806007866 binding surface 378806007867 TPR motif; other site 378806007868 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806007869 phosphopeptide binding site; other site 378806007870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806007871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806007872 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229 378806007873 Predicted RNA interaction site [nucleotide binding]; other site 378806007874 putative binding site; other site 378806007875 Mutations affecting start-site selection; other site 378806007876 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 378806007877 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 378806007878 putative ligand binding site [chemical binding]; other site 378806007879 Competence protein; Region: Competence; cl00471 378806007880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806007881 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 378806007882 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806007883 phosphopeptide binding site; other site 378806007884 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 378806007885 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806007886 active site 378806007887 HIGH motif; other site 378806007888 nucleotide binding site [chemical binding]; other site 378806007889 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 378806007890 KMSKS motif; other site 378806007891 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 378806007892 tRNA binding surface [nucleotide binding]; other site 378806007893 anticodon binding site; other site 378806007894 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806007895 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238 378806007896 PA/protease or protease-like domain interface [polypeptide binding]; other site 378806007897 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 378806007898 metal binding site [ion binding]; metal-binding site 378806007899 excinuclease ABC subunit B; Provisional; Region: PRK05298 378806007900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806007901 ATP binding site [chemical binding]; other site 378806007902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806007903 nucleotide binding region [chemical binding]; other site 378806007904 ATP-binding site [chemical binding]; other site 378806007905 Ultra-violet resistance protein B; Region: UvrB; pfam12344 378806007906 UvrB/uvrC motif; Region: UVR; pfam02151 378806007907 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 378806007908 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 378806007909 UvrB/uvrC motif; Region: UVR; pfam02151 378806007910 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 378806007911 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 378806007912 Protein of unknown function (DUF507); Region: DUF507; cl01112 378806007913 large tegument protein UL36; Provisional; Region: PHA03247 378806007914 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 378806007915 Imelysin; Region: Peptidase_M75; cl09159 378806007916 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 378806007917 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 378806007918 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 378806007919 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 378806007920 catalytic residue [active] 378806007921 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 378806007922 active site 378806007923 dimer interface [polypeptide binding]; other site 378806007924 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806007925 GAF domain; Region: GAF; cl00853 378806007926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806007927 metal binding site [ion binding]; metal-binding site 378806007928 active site 378806007929 I-site; other site 378806007930 SurA N-terminal domain; Region: SurA_N; pfam09312 378806007931 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 378806007932 PPIC-type PPIASE domain; Region: Rotamase; cl08278 378806007933 rod shape-determining protein MreC; Region: MreC; pfam04085 378806007934 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 378806007935 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 378806007936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 378806007937 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 378806007938 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 378806007939 MgtE intracellular N domain; Region: MgtE_N; cl15244 378806007940 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 378806007941 Divalent cation transporter; Region: MgtE; cl00786 378806007942 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 378806007943 catalytic residues [active] 378806007944 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 378806007945 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 378806007946 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 378806007947 tRNA; other site 378806007948 putative tRNA binding site [nucleotide binding]; other site 378806007949 putative NADP binding site [chemical binding]; other site 378806007950 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 378806007951 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 378806007952 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 378806007953 domain interfaces; other site 378806007954 active site 378806007955 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 378806007956 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 378806007957 active site 378806007958 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 378806007959 active site 378806007960 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 378806007961 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806007962 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 378806007963 Walker A motif; other site 378806007964 ATP binding site [chemical binding]; other site 378806007965 Walker B motif; other site 378806007966 type III secretion system protein SpaO; Validated; Region: PRK08158 378806007967 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 378806007968 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 378806007969 active site 378806007970 metal binding site [ion binding]; metal-binding site 378806007971 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 378806007972 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 378806007973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806007974 putative substrate translocation pore; other site 378806007975 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 378806007976 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 378806007977 tetramer interface [polypeptide binding]; other site 378806007978 TPP-binding site [chemical binding]; other site 378806007979 heterodimer interface [polypeptide binding]; other site 378806007980 phosphorylation loop region [posttranslational modification] 378806007981 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 378806007982 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 378806007983 alpha subunit interface [polypeptide binding]; other site 378806007984 TPP binding site [chemical binding]; other site 378806007985 heterodimer interface [polypeptide binding]; other site 378806007986 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 378806007987 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 378806007988 E3 interaction surface; other site 378806007989 lipoyl attachment site [posttranslational modification]; other site 378806007990 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 378806007991 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 378806007992 E3 interaction surface; other site 378806007993 lipoyl attachment site [posttranslational modification]; other site 378806007994 e3 binding domain; Region: E3_binding; pfam02817 378806007995 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 378806007996 Response regulator receiver domain; Region: Response_reg; pfam00072 378806007997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806007998 active site 378806007999 phosphorylation site [posttranslational modification] 378806008000 intermolecular recognition site; other site 378806008001 dimerization interface [polypeptide binding]; other site 378806008002 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806008003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806008004 ATP binding site [chemical binding]; other site 378806008005 Mg2+ binding site [ion binding]; other site 378806008006 G-X-G motif; other site 378806008007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806008008 active site 378806008009 phosphorylation site [posttranslational modification] 378806008010 intermolecular recognition site; other site 378806008011 dimerization interface [polypeptide binding]; other site 378806008012 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 378806008013 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 378806008014 HIGH motif; other site 378806008015 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 378806008016 active site 378806008017 KMSKS motif; other site 378806008018 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806008019 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 378806008020 active site 378806008021 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 378806008022 active site 378806008023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806008024 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 378806008025 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806008026 active site 378806008027 ATP binding site [chemical binding]; other site 378806008028 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806008029 substrate binding site [chemical binding]; other site 378806008030 activation loop (A-loop); other site 378806008031 PEGA domain; Region: PEGA; pfam08308 378806008032 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806008033 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806008034 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 378806008035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806008036 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806008037 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806008038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806008039 active site 378806008040 phosphorylation site [posttranslational modification] 378806008041 intermolecular recognition site; other site 378806008042 dimerization interface [polypeptide binding]; other site 378806008043 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806008044 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 378806008045 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 378806008046 putative binding surface; other site 378806008047 active site 378806008048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806008049 ATP binding site [chemical binding]; other site 378806008050 Mg2+ binding site [ion binding]; other site 378806008051 G-X-G motif; other site 378806008052 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806008053 Response regulator receiver domain; Region: Response_reg; pfam00072 378806008054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806008055 active site 378806008056 phosphorylation site [posttranslational modification] 378806008057 intermolecular recognition site; other site 378806008058 dimerization interface [polypeptide binding]; other site 378806008059 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 378806008060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806008061 Heparinase II/III-like protein; Region: Hepar_II_III; cl02215 378806008062 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 378806008063 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 378806008064 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 378806008065 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 378806008066 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806008067 putative sugar binding sites [chemical binding]; other site 378806008068 Q-X-W motif; other site 378806008069 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 378806008070 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806008071 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806008072 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806008073 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806008074 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806008075 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806008076 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806008077 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806008078 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806008079 Uncharacterized conserved protein [Function unknown]; Region: COG3945 378806008080 Uncharacterized conserved protein [Function unknown]; Region: COG5592 378806008081 Sulfatase; Region: Sulfatase; cl10460 378806008082 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 378806008083 G1 box; other site 378806008084 GTP/Mg2+ binding site [chemical binding]; other site 378806008085 G2 box; other site 378806008086 Switch I region; other site 378806008087 G3 box; other site 378806008088 Switch II region; other site 378806008089 G4 box; other site 378806008090 G5 box; other site 378806008091 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 378806008092 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 378806008093 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 378806008094 putative active site [active] 378806008095 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 378806008096 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 378806008097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806008098 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 378806008099 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 378806008100 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 378806008101 UbiA prenyltransferase family; Region: UbiA; cl00337 378806008102 Major royal jelly protein; Region: MRJP; pfam03022 378806008103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806008104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806008105 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 378806008106 putative effector binding pocket; other site 378806008107 dimerization interface [polypeptide binding]; other site 378806008108 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 378806008109 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 378806008110 active site 378806008111 substrate binding site [chemical binding]; other site 378806008112 cosubstrate binding site; other site 378806008113 catalytic site [active] 378806008114 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 378806008115 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 378806008116 dimerization interface [polypeptide binding]; other site 378806008117 putative ATP binding site [chemical binding]; other site 378806008118 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806008119 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 378806008120 ligand binding site [chemical binding]; other site 378806008121 flexible hinge region; other site 378806008122 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806008123 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 378806008124 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 378806008125 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 378806008126 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378806008127 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378806008128 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 378806008129 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 378806008130 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 378806008131 Organic solvent tolerance protein; Region: OstA_C; pfam04453 378806008132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 378806008133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806008134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806008135 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806008136 enoyl-CoA hydratase; Provisional; Region: PRK05995 378806008137 substrate binding site [chemical binding]; other site 378806008138 oxyanion hole (OAH) forming residues; other site 378806008139 trimer interface [polypeptide binding]; other site 378806008140 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806008141 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806008142 putative catalytic site [active] 378806008143 putative metal binding site [ion binding]; other site 378806008144 putative phosphate binding site [ion binding]; other site 378806008145 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 378806008146 CHASE2 domain; Region: CHASE2; cl01732 378806008147 CHASE2 domain; Region: CHASE2; cl01732 378806008148 cyclase homology domain; Region: CHD; cd07302 378806008149 nucleotidyl binding site; other site 378806008150 metal binding site [ion binding]; metal-binding site 378806008151 dimer interface [polypeptide binding]; other site 378806008152 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 378806008153 dimer interface [polypeptide binding]; other site 378806008154 [2Fe-2S] cluster binding site [ion binding]; other site 378806008155 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 378806008156 4Fe-4S binding domain; Region: Fer4; cl02805 378806008157 NADH dehydrogenase; Region: NADHdh; cl00469 378806008158 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 378806008159 catalytic loop [active] 378806008160 iron binding site [ion binding]; other site 378806008161 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 378806008162 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 378806008163 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 378806008164 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 378806008165 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 378806008166 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 378806008167 cyclase homology domain; Region: CHD; cd07302 378806008168 nucleotidyl binding site; other site 378806008169 metal binding site [ion binding]; metal-binding site 378806008170 dimer interface [polypeptide binding]; other site 378806008171 Sulfatase; Region: Sulfatase; cl10460 378806008172 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 378806008173 CoenzymeA binding site [chemical binding]; other site 378806008174 subunit interaction site [polypeptide binding]; other site 378806008175 PHB binding site; other site 378806008176 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 378806008177 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 378806008178 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806008179 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806008180 Response regulator receiver domain; Region: Response_reg; pfam00072 378806008181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806008182 active site 378806008183 phosphorylation site [posttranslational modification] 378806008184 intermolecular recognition site; other site 378806008185 dimerization interface [polypeptide binding]; other site 378806008186 circadian clock protein KaiC; Reviewed; Region: PRK09302 378806008187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806008188 Walker A motif; other site 378806008189 ATP binding site [chemical binding]; other site 378806008190 Walker B motif; other site 378806008191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806008192 ATP binding site [chemical binding]; other site 378806008193 Walker B motif; other site 378806008194 Response regulator receiver domain; Region: Response_reg; pfam00072 378806008195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806008196 active site 378806008197 phosphorylation site [posttranslational modification] 378806008198 intermolecular recognition site; other site 378806008199 dimerization interface [polypeptide binding]; other site 378806008200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806008201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806008202 ATP binding site [chemical binding]; other site 378806008203 Mg2+ binding site [ion binding]; other site 378806008204 G-X-G motif; other site 378806008205 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 378806008206 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 378806008207 Deoxyhypusine synthase; Region: DS; cl00826 378806008208 OsmC-like protein; Region: OsmC; cl00767 378806008209 Phosphoesterase family; Region: Phosphoesterase; cl10627 378806008210 Phosphoesterase family; Region: Phosphoesterase; cl10627 378806008211 arginine decarboxylase; Provisional; Region: PRK05354 378806008212 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 378806008213 active site 378806008214 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 378806008215 dimer interface [polypeptide binding]; other site 378806008216 catalytic residues [active] 378806008217 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 378806008218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806008219 Walker A motif; other site 378806008220 ATP binding site [chemical binding]; other site 378806008221 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 378806008222 Walker B motif; other site 378806008223 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378806008224 Colicin V production protein; Region: Colicin_V; cl00567 378806008225 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 378806008226 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 378806008227 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 378806008228 active site 378806008229 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000 378806008230 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806008231 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806008232 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806008233 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 378806008234 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 378806008235 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 378806008236 putative hydrophobic ligand binding site [chemical binding]; other site 378806008237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378806008238 dimerization interface [polypeptide binding]; other site 378806008239 putative DNA binding site [nucleotide binding]; other site 378806008240 putative Zn2+ binding site [ion binding]; other site 378806008241 hypothetical protein; Provisional; Region: PRK08609 378806008242 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 378806008243 active site 378806008244 primer binding site [nucleotide binding]; other site 378806008245 NTP binding site [chemical binding]; other site 378806008246 metal binding triad [ion binding]; metal-binding site 378806008247 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 378806008248 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 378806008249 iron-sulfur cluster [ion binding]; other site 378806008250 [2Fe-2S] cluster binding site [ion binding]; other site 378806008251 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 378806008252 MPT binding site; other site 378806008253 trimer interface [polypeptide binding]; other site 378806008254 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 378806008255 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 378806008256 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 378806008257 heme-binding site [chemical binding]; other site 378806008258 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 378806008259 FAD binding pocket [chemical binding]; other site 378806008260 FAD binding motif [chemical binding]; other site 378806008261 phosphate binding motif [ion binding]; other site 378806008262 beta-alpha-beta structure motif; other site 378806008263 NAD binding pocket [chemical binding]; other site 378806008264 Heme binding pocket [chemical binding]; other site 378806008265 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 378806008266 GAF domain; Region: GAF; cl00853 378806008267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806008268 Walker A motif; other site 378806008269 ATP binding site [chemical binding]; other site 378806008270 Walker B motif; other site 378806008271 arginine finger; other site 378806008272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806008273 binding surface 378806008274 TPR motif; other site 378806008275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806008276 binding surface 378806008277 TPR motif; other site 378806008278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806008279 binding surface 378806008280 TPR motif; other site 378806008281 CHAT domain; Region: CHAT; cl02083 378806008282 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806008283 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806008284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806008285 NAD(P) binding site [chemical binding]; other site 378806008286 active site 378806008287 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 378806008288 CoenzymeA binding site [chemical binding]; other site 378806008289 subunit interaction site [polypeptide binding]; other site 378806008290 PHB binding site; other site 378806008291 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 378806008292 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806008293 putative active site [active] 378806008294 putative metal binding site [ion binding]; other site 378806008295 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 378806008296 catalytic site [active] 378806008297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806008298 binding surface 378806008299 TPR motif; other site 378806008300 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 378806008301 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 378806008302 putative active site [active] 378806008303 putative catalytic site [active] 378806008304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806008305 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 378806008306 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806008307 Walker A/P-loop; other site 378806008308 ATP binding site [chemical binding]; other site 378806008309 Q-loop/lid; other site 378806008310 ABC transporter signature motif; other site 378806008311 Walker B; other site 378806008312 D-loop; other site 378806008313 H-loop/switch region; other site 378806008314 TOBE domain; Region: TOBE_2; cl01440 378806008315 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 378806008316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806008317 dimer interface [polypeptide binding]; other site 378806008318 conserved gate region; other site 378806008319 putative PBP binding loops; other site 378806008320 ABC-ATPase subunit interface; other site 378806008321 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 378806008322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 378806008323 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806008324 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 378806008325 tetrameric interface [polypeptide binding]; other site 378806008326 NAD binding site [chemical binding]; other site 378806008327 catalytic residues [active] 378806008328 substrate binding site [chemical binding]; other site 378806008329 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 378806008330 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806008331 inhibitor-cofactor binding pocket; inhibition site 378806008332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806008333 catalytic residue [active] 378806008334 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl01543 378806008335 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 378806008336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806008337 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 378806008338 peptide synthase; Validated; Region: PRK05691 378806008339 Condensation domain; Region: Condensation; cl09290 378806008340 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806008341 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 378806008342 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 378806008343 Walker A/P-loop; other site 378806008344 ATP binding site [chemical binding]; other site 378806008345 Q-loop/lid; other site 378806008346 ABC transporter signature motif; other site 378806008347 Walker B; other site 378806008348 D-loop; other site 378806008349 H-loop/switch region; other site 378806008350 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 378806008351 Probable Catalytic site [active] 378806008352 metal binding site [ion binding]; metal-binding site 378806008353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 378806008354 active site 378806008355 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 378806008356 Probable Catalytic site [active] 378806008357 metal binding site [ion binding]; metal-binding site 378806008358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378806008359 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806008360 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 378806008361 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 378806008362 NAD binding site [chemical binding]; other site 378806008363 substrate binding site [chemical binding]; other site 378806008364 homodimer interface [polypeptide binding]; other site 378806008365 active site 378806008366 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 378806008367 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 378806008368 NADP binding site [chemical binding]; other site 378806008369 active site 378806008370 putative substrate binding site [chemical binding]; other site 378806008371 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 378806008372 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 378806008373 substrate binding site [chemical binding]; other site 378806008374 tetramer interface [polypeptide binding]; other site 378806008375 Cupin domain; Region: Cupin_2; cl09118 378806008376 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 378806008377 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 378806008378 metal ion-dependent adhesion site (MIDAS); other site 378806008379 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806008380 active site 378806008381 ATP binding site [chemical binding]; other site 378806008382 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806008383 substrate binding site [chemical binding]; other site 378806008384 activation loop (A-loop); other site 378806008385 PEGA domain; Region: PEGA; pfam08308 378806008386 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 378806008387 UbiA prenyltransferase family; Region: UbiA; cl00337 378806008388 UbiA prenyltransferase family; Region: UbiA; cl00337 378806008389 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 378806008390 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806008391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806008392 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806008393 ABC transporter; Region: ABC_tran_2; pfam12848 378806008394 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806008395 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 378806008396 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 378806008397 Predicted membrane protein [Function unknown]; Region: COG2311 378806008398 Protein of unknown function (DUF418); Region: DUF418; cl12135 378806008399 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 378806008400 active site 378806008401 Cupin domain; Region: Cupin_2; cl09118 378806008402 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 378806008403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806008404 Walker A motif; other site 378806008405 ATP binding site [chemical binding]; other site 378806008406 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 378806008407 AAA-like domain; Region: AAA_10; pfam12846 378806008408 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806008409 Walker A motif; other site 378806008410 ATP binding site [chemical binding]; other site 378806008411 Walker B motif; other site 378806008412 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 378806008413 putative active site [active] 378806008414 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 378806008415 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 378806008416 Ligand binding site [chemical binding]; other site 378806008417 DXD motif; other site 378806008418 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl01208 378806008419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806008420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806008421 alanine dehydrogenase, Archaeoglobus fulgidus type; Region: ala_DH_arch; TIGR02371 378806008422 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 378806008423 short chain dehydrogenase; Provisional; Region: PRK06181 378806008424 NADP binding site [chemical binding]; other site 378806008425 homodimer interface [polypeptide binding]; other site 378806008426 substrate binding site [chemical binding]; other site 378806008427 active site 378806008428 Superfamily II helicase [General function prediction only]; Region: COG1204 378806008429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806008430 ATP binding site [chemical binding]; other site 378806008431 putative Mg++ binding site [ion binding]; other site 378806008432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806008433 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 378806008434 Cytochrome P450; Region: p450; cl12078 378806008435 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 378806008436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806008437 tellurium resistance terB-like protein; Region: terB_like; cl11965 378806008438 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 378806008439 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 378806008440 intersubunit interface [polypeptide binding]; other site 378806008441 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 378806008442 ABC-ATPase subunit interface; other site 378806008443 dimer interface [polypeptide binding]; other site 378806008444 putative PBP binding regions; other site 378806008445 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 378806008446 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 378806008447 Walker A/P-loop; other site 378806008448 ATP binding site [chemical binding]; other site 378806008449 Q-loop/lid; other site 378806008450 ABC transporter signature motif; other site 378806008451 Walker B; other site 378806008452 D-loop; other site 378806008453 H-loop/switch region; other site 378806008454 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 378806008455 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806008456 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806008457 catalytic residue [active] 378806008458 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 378806008459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806008460 putative substrate translocation pore; other site 378806008461 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806008462 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806008463 N-terminal plug; other site 378806008464 ligand-binding site [chemical binding]; other site 378806008465 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 378806008466 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 378806008467 Condensation domain; Region: Condensation; cl09290 378806008468 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806008469 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806008470 thioester reductase domain; Region: Thioester-redct; TIGR01746 378806008471 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 378806008472 putative NAD(P) binding site [chemical binding]; other site 378806008473 active site 378806008474 putative substrate binding site [chemical binding]; other site 378806008475 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in...; Region: isochorismatase; cd01013 378806008476 hydrophobic substrate binding pocket; other site 378806008477 Isochorismatase family; Region: Isochorismatase; pfam00857 378806008478 active site 378806008479 conserved cis-peptide bond; other site 378806008480 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806008481 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 378806008482 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806008483 isochorismate synthase DhbC; Validated; Region: PRK06923 378806008484 chorismate binding enzyme; Region: Chorismate_bind; cl10555 378806008485 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806008486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806008487 NAD(P) binding site [chemical binding]; other site 378806008488 active site 378806008489 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 378806008490 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 378806008491 FAD binding pocket [chemical binding]; other site 378806008492 FAD binding motif [chemical binding]; other site 378806008493 phosphate binding motif [ion binding]; other site 378806008494 NAD binding pocket [chemical binding]; other site 378806008495 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806008496 active site 378806008497 catalytic tetrad [active] 378806008498 SelR domain; Region: SelR; cl00369 378806008499 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806008500 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 378806008501 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 378806008502 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 378806008503 substrate binding site [chemical binding]; other site 378806008504 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 378806008505 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 378806008506 substrate binding site [chemical binding]; other site 378806008507 ligand binding site [chemical binding]; other site 378806008508 2-isopropylmalate synthase; Validated; Region: PRK00915 378806008509 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 378806008510 active site 378806008511 catalytic residues [active] 378806008512 metal binding site [ion binding]; metal-binding site 378806008513 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 378806008514 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 378806008515 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 378806008516 NADP binding site [chemical binding]; other site 378806008517 putative substrate binding site [chemical binding]; other site 378806008518 active site 378806008519 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 378806008520 Trp docking motif; other site 378806008521 'Velcro' closure; other site 378806008522 active site 378806008523 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 378806008524 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 378806008525 lipoyl attachment site [posttranslational modification]; other site 378806008526 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806008527 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806008528 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 378806008529 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 378806008530 DNA binding residues [nucleotide binding] 378806008531 putative dimer interface [polypeptide binding]; other site 378806008532 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 378806008533 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 378806008534 Zn binding site [ion binding]; other site 378806008535 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cl03075 378806008536 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806008537 Integrase core domain; Region: rve; cl01316 378806008538 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 378806008539 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 378806008540 domain; Region: GreA_GreB_N; pfam03449 378806008541 C-term; Region: GreA_GreB; pfam01272 378806008542 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 378806008543 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 378806008544 putative active site [active] 378806008545 PhoH-like protein; Region: PhoH; cl12134 378806008546 Protein of unknown function (DUF493); Region: DUF493; cl01102 378806008547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806008548 S-adenosylmethionine binding site [chemical binding]; other site 378806008549 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 378806008550 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 378806008551 MoxR-like ATPases [General function prediction only]; Region: COG0714 378806008552 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 378806008553 metal ion-dependent adhesion site (MIDAS); other site 378806008554 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806008555 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 378806008556 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 378806008557 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 378806008558 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 378806008559 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806008560 phosphopeptide binding site; other site 378806008561 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806008562 active site 378806008563 ATP binding site [chemical binding]; other site 378806008564 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806008565 substrate binding site [chemical binding]; other site 378806008566 activation loop (A-loop); other site 378806008567 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 378806008568 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 378806008569 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 378806008570 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 378806008571 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 378806008572 synthetase active site [active] 378806008573 NTP binding site [chemical binding]; other site 378806008574 metal binding site [ion binding]; metal-binding site 378806008575 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 378806008576 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 378806008577 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 378806008578 homotrimer interaction site [polypeptide binding]; other site 378806008579 putative active site [active] 378806008580 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806008581 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 378806008582 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806008583 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 378806008584 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806008585 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 378806008586 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378806008587 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 378806008588 Walker A/P-loop; other site 378806008589 ATP binding site [chemical binding]; other site 378806008590 Q-loop/lid; other site 378806008591 ABC transporter signature motif; other site 378806008592 Walker B; other site 378806008593 D-loop; other site 378806008594 H-loop/switch region; other site 378806008595 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 378806008596 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 378806008597 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806008598 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 378806008599 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806008600 metal binding site [ion binding]; metal-binding site 378806008601 active site 378806008602 I-site; other site 378806008603 Response regulator receiver domain; Region: Response_reg; pfam00072 378806008604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806008605 active site 378806008606 phosphorylation site [posttranslational modification] 378806008607 intermolecular recognition site; other site 378806008608 dimerization interface [polypeptide binding]; other site 378806008609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806008610 Walker A motif; other site 378806008611 ATP binding site [chemical binding]; other site 378806008612 Walker B motif; other site 378806008613 arginine finger; other site 378806008614 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806008615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806008616 NAD(P) binding site [chemical binding]; other site 378806008617 active site 378806008618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806008619 binding surface 378806008620 TPR motif; other site 378806008621 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 378806008622 NeuB family; Region: NeuB; cl00496 378806008623 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 378806008624 Prephenate dehydratase; Region: PDT; pfam00800 378806008625 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 378806008626 putative L-Phe binding site [chemical binding]; other site 378806008627 Chorismate mutase type II; Region: CM_2; cl00693 378806008628 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 378806008629 Prephenate dehydratase; Region: PDT; pfam00800 378806008630 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 378806008631 putative L-Phe binding site [chemical binding]; other site 378806008632 EVE domain; Region: EVE; cl00728 378806008633 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 378806008634 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 378806008635 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 378806008636 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 378806008637 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 378806008638 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806008639 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 378806008640 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 378806008641 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 378806008642 SLBB domain; Region: SLBB; pfam10531 378806008643 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 378806008644 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 378806008645 Bacterial sugar transferase; Region: Bac_transf; cl00939 378806008646 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 378806008647 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 378806008648 phosphate binding site [ion binding]; other site 378806008649 putative substrate binding pocket [chemical binding]; other site 378806008650 dimer interface [polypeptide binding]; other site 378806008651 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 378806008652 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806008653 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806008654 catalytic residue [active] 378806008655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806008656 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 378806008657 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 378806008658 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806008659 sugar binding site [chemical binding]; other site 378806008660 Predicted membrane protein [Function unknown]; Region: COG4267 378806008661 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_3; cd03813 378806008662 TM1410 hypothetical-related protein; Region: DUF297; cl00997 378806008663 TM1410 hypothetical-related protein; Region: DUF297; cl00997 378806008664 Predicted outer membrane protein [Function unknown]; Region: COG3652 378806008665 Kelch motif; Region: Kelch_1; cl02701 378806008666 Kelch motif; Region: Kelch_1; cl02701 378806008667 Kelch motif; Region: Kelch_1; cl02701 378806008668 Kelch motif; Region: Kelch_1; cl02701 378806008669 kelch-like protein; Provisional; Region: PHA03098 378806008670 Kelch motif; Region: Kelch_1; cl02701 378806008671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806008672 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806008673 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 378806008674 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 378806008675 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806008676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806008677 DNA-binding site [nucleotide binding]; DNA binding site 378806008678 EBNA-3B; Provisional; Region: PHA03378 378806008679 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 378806008680 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806008681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806008682 TPR motif; other site 378806008683 binding surface 378806008684 Cytochrome C biogenesis protein; Region: CcmH; cl01179 378806008685 Zn-ribbon containing protein [General function prediction only]; Region: COG3364 378806008686 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 378806008687 catalytic residues [active] 378806008688 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 378806008689 CcmE; Region: CcmE; cl00994 378806008690 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 378806008691 CcmB protein; Region: CcmB; cl01016 378806008692 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 378806008693 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 378806008694 Walker A/P-loop; other site 378806008695 ATP binding site [chemical binding]; other site 378806008696 Q-loop/lid; other site 378806008697 ABC transporter signature motif; other site 378806008698 Walker B; other site 378806008699 D-loop; other site 378806008700 H-loop/switch region; other site 378806008701 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 378806008702 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 378806008703 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 378806008704 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 378806008705 trimer interface [polypeptide binding]; other site 378806008706 active site 378806008707 substrate binding site [chemical binding]; other site 378806008708 CoA binding site [chemical binding]; other site 378806008709 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806008710 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 378806008711 putative homodimer interface [polypeptide binding]; other site 378806008712 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 378806008713 Cytochrome c; Region: Cytochrom_C; cl11414 378806008714 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 378806008715 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806008716 active site 378806008717 ATP binding site [chemical binding]; other site 378806008718 substrate binding site [chemical binding]; other site 378806008719 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806008720 activation loop (A-loop); other site 378806008721 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 378806008722 active site 378806008723 dimer interface [polypeptide binding]; other site 378806008724 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 378806008725 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 378806008726 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 378806008727 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 378806008728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806008729 active site 378806008730 motif I; other site 378806008731 motif II; other site 378806008732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806008733 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 378806008734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806008735 S-adenosylmethionine binding site [chemical binding]; other site 378806008736 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 378806008737 active site 378806008738 catalytic triad [active] 378806008739 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 378806008740 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 378806008741 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 378806008742 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 378806008743 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 378806008744 putative acyl-acceptor binding pocket; other site 378806008745 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 378806008746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806008747 dimer interface [polypeptide binding]; other site 378806008748 phosphorylation site [posttranslational modification] 378806008749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806008750 ATP binding site [chemical binding]; other site 378806008751 Mg2+ binding site [ion binding]; other site 378806008752 G-X-G motif; other site 378806008753 Response regulator receiver domain; Region: Response_reg; pfam00072 378806008754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806008755 active site 378806008756 phosphorylation site [posttranslational modification] 378806008757 intermolecular recognition site; other site 378806008758 dimerization interface [polypeptide binding]; other site 378806008759 Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]; Region: SEC21; COG5240 378806008760 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 378806008761 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 378806008762 HSP70 interaction site [polypeptide binding]; other site 378806008763 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 378806008764 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 378806008765 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 378806008766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806008767 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 378806008768 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 378806008769 S17 interaction site [polypeptide binding]; other site 378806008770 S8 interaction site; other site 378806008771 16S rRNA interaction site [nucleotide binding]; other site 378806008772 streptomycin interaction site [chemical binding]; other site 378806008773 23S rRNA interaction site [nucleotide binding]; other site 378806008774 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 378806008775 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 378806008776 elongation factor G; Reviewed; Region: PRK00007 378806008777 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 378806008778 G1 box; other site 378806008779 putative GEF interaction site [polypeptide binding]; other site 378806008780 GTP/Mg2+ binding site [chemical binding]; other site 378806008781 Switch I region; other site 378806008782 G2 box; other site 378806008783 G3 box; other site 378806008784 Switch II region; other site 378806008785 G4 box; other site 378806008786 G5 box; other site 378806008787 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 378806008788 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 378806008789 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 378806008790 elongation factor Tu; Reviewed; Region: PRK00049 378806008791 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 378806008792 G1 box; other site 378806008793 GEF interaction site [polypeptide binding]; other site 378806008794 GTP/Mg2+ binding site [chemical binding]; other site 378806008795 Switch I region; other site 378806008796 G2 box; other site 378806008797 G3 box; other site 378806008798 Switch II region; other site 378806008799 G4 box; other site 378806008800 G5 box; other site 378806008801 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 378806008802 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 378806008803 Antibiotic Binding Site [chemical binding]; other site 378806008804 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 378806008805 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 378806008806 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 378806008807 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 378806008808 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 378806008809 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 378806008810 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 378806008811 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 378806008812 putative translocon binding site; other site 378806008813 protein-rRNA interface [nucleotide binding]; other site 378806008814 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 378806008815 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 378806008816 G-X-X-G motif; other site 378806008817 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 378806008818 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 378806008819 23S rRNA interface [nucleotide binding]; other site 378806008820 5S rRNA interface [nucleotide binding]; other site 378806008821 putative antibiotic binding site [chemical binding]; other site 378806008822 L25 interface [polypeptide binding]; other site 378806008823 L27 interface [polypeptide binding]; other site 378806008824 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 378806008825 putative translocon interaction site; other site 378806008826 23S rRNA interface [nucleotide binding]; other site 378806008827 signal recognition particle (SRP54) interaction site; other site 378806008828 L23 interface [polypeptide binding]; other site 378806008829 trigger factor interaction site; other site 378806008830 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 378806008831 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 378806008832 KOW motif; Region: KOW; cl00354 378806008833 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 378806008834 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 378806008835 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 378806008836 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 378806008837 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 378806008838 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 378806008839 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 378806008840 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 378806008841 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 378806008842 23S rRNA interface [nucleotide binding]; other site 378806008843 5S rRNA interface [nucleotide binding]; other site 378806008844 L27 interface [polypeptide binding]; other site 378806008845 L5 interface [polypeptide binding]; other site 378806008846 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 378806008847 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 378806008848 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 378806008849 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 378806008850 23S rRNA binding site [nucleotide binding]; other site 378806008851 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 378806008852 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 378806008853 SecY translocase; Region: SecY; pfam00344 378806008854 adenylate kinase; Reviewed; Region: adk; PRK00279 378806008855 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 378806008856 AMP-binding site [chemical binding]; other site 378806008857 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 378806008858 methionine aminopeptidase; Reviewed; Region: PRK07281 378806008859 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 378806008860 active site 378806008861 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 378806008862 rRNA binding site [nucleotide binding]; other site 378806008863 predicted 30S ribosome binding site; other site 378806008864 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 378806008865 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 378806008866 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 378806008867 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 378806008868 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 378806008869 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 378806008870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378806008871 RNA binding surface [nucleotide binding]; other site 378806008872 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 378806008873 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 378806008874 alphaNTD homodimer interface [polypeptide binding]; other site 378806008875 alphaNTD - beta interaction site [polypeptide binding]; other site 378806008876 alphaNTD - beta' interaction site [polypeptide binding]; other site 378806008877 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 378806008878 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 378806008879 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806008880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806008881 TPR motif; other site 378806008882 binding surface 378806008883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806008884 binding surface 378806008885 TPR motif; other site 378806008886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806008887 binding surface 378806008888 TPR motif; other site 378806008889 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 378806008890 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378806008891 putative acyl-acceptor binding pocket; other site 378806008892 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 378806008893 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 378806008894 Substrate-binding site [chemical binding]; other site 378806008895 Substrate specificity [chemical binding]; other site 378806008896 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 378806008897 Peptidase family C69; Region: Peptidase_C69; cl01920 378806008898 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 378806008899 dimer interface [polypeptide binding]; other site 378806008900 ADP-ribose binding site [chemical binding]; other site 378806008901 active site 378806008902 nudix motif; other site 378806008903 metal binding site [ion binding]; metal-binding site 378806008904 GAF domain; Region: GAF; cl00853 378806008905 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 378806008906 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806008907 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 378806008908 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806008909 active site 378806008910 ATP binding site [chemical binding]; other site 378806008911 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806008912 substrate binding site [chemical binding]; other site 378806008913 activation loop (A-loop); other site 378806008914 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 378806008915 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806008916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806008917 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806008918 ABC transporter; Region: ABC_tran_2; pfam12848 378806008919 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806008920 peptide chain release factor 2; Validated; Region: prfB; PRK00578 378806008921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806008922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806008923 dimer interface [polypeptide binding]; other site 378806008924 conserved gate region; other site 378806008925 ABC-ATPase subunit interface; other site 378806008926 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 378806008927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806008928 Walker A/P-loop; other site 378806008929 ATP binding site [chemical binding]; other site 378806008930 Q-loop/lid; other site 378806008931 ABC transporter signature motif; other site 378806008932 Walker B; other site 378806008933 D-loop; other site 378806008934 H-loop/switch region; other site 378806008935 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 378806008936 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 378806008937 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806008938 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806008939 Integrase core domain; Region: rve; cl01316 378806008940 Phage capsid family; Region: Phage_capsid; pfam05065 378806008941 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806008942 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806008943 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 378806008944 active site 378806008945 metal binding site [ion binding]; metal-binding site 378806008946 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 378806008947 tandem repeat interface [polypeptide binding]; other site 378806008948 oligomer interface [polypeptide binding]; other site 378806008949 active site residues [active] 378806008950 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 378806008951 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 378806008952 tandem repeat interface [polypeptide binding]; other site 378806008953 oligomer interface [polypeptide binding]; other site 378806008954 active site residues [active] 378806008955 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 378806008956 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 378806008957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 378806008958 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 378806008959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806008960 active site 378806008961 phosphorylation site [posttranslational modification] 378806008962 intermolecular recognition site; other site 378806008963 dimerization interface [polypeptide binding]; other site 378806008964 CheB methylesterase; Region: CheB_methylest; pfam01339 378806008965 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806008966 GAF domain; Region: GAF; cl00853 378806008967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806008968 phosphorylation site [posttranslational modification] 378806008969 dimer interface [polypeptide binding]; other site 378806008970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806008971 ATP binding site [chemical binding]; other site 378806008972 Mg2+ binding site [ion binding]; other site 378806008973 G-X-G motif; other site 378806008974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 378806008975 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 378806008976 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806008977 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806008978 catalytic residue [active] 378806008979 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 378806008980 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806008981 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 378806008982 active site 378806008983 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 378806008984 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806008985 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 378806008986 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 378806008987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 378806008988 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806008989 active site 378806008990 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 378806008991 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806008992 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 378806008993 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 378806008994 catalytic triad [active] 378806008995 active site 378806008996 oxyanion hole [active] 378806008997 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 378806008998 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806008999 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 378806009000 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806009001 OPT oligopeptide transporter protein; Region: OPT; cl14607 378806009002 OPT oligopeptide transporter protein; Region: OPT; cl14607 378806009003 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 378806009004 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 378806009005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806009006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806009007 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 378806009008 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 378806009009 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 378806009010 Protein of unknown function DUF58; Region: DUF58; pfam01882 378806009011 MoxR-like ATPases [General function prediction only]; Region: COG0714 378806009012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806009013 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 378806009014 anti sigma factor interaction site; other site 378806009015 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806009016 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806009017 catalytic residue [active] 378806009018 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 378806009019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806009020 binding surface 378806009021 TPR motif; other site 378806009022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806009023 TPR motif; other site 378806009024 binding surface 378806009025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806009026 binding surface 378806009027 TPR motif; other site 378806009028 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 378806009029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806009030 binding surface 378806009031 TPR motif; other site 378806009032 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806009033 phosphopeptide binding site; other site 378806009034 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806009035 Response regulator receiver domain; Region: Response_reg; pfam00072 378806009036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806009037 active site 378806009038 phosphorylation site [posttranslational modification] 378806009039 intermolecular recognition site; other site 378806009040 dimerization interface [polypeptide binding]; other site 378806009041 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 378806009042 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 378806009043 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 378806009044 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806009045 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806009046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806009047 TPR motif; other site 378806009048 binding surface 378806009049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806009050 binding surface 378806009051 TPR motif; other site 378806009052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806009053 binding surface 378806009054 TPR motif; other site 378806009055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806009056 binding surface 378806009057 TPR motif; other site 378806009058 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 378806009059 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 378806009060 G1 box; other site 378806009061 putative GEF interaction site [polypeptide binding]; other site 378806009062 GTP/Mg2+ binding site [chemical binding]; other site 378806009063 Switch I region; other site 378806009064 G2 box; other site 378806009065 G3 box; other site 378806009066 Switch II region; other site 378806009067 G4 box; other site 378806009068 G5 box; other site 378806009069 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 378806009070 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 378806009071 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806009072 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806009073 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 378806009074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806009075 Walker A motif; other site 378806009076 ATP binding site [chemical binding]; other site 378806009077 Walker B motif; other site 378806009078 arginine finger; other site 378806009079 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806009080 Cation efflux family; Region: Cation_efflux; cl00316 378806009081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806009082 S-adenosylmethionine binding site [chemical binding]; other site 378806009083 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 378806009084 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 378806009085 active site 378806009086 (T/H)XGH motif; other site 378806009087 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 378806009088 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378806009089 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806009090 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 378806009091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378806009092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806009093 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 378806009094 IMP binding site; other site 378806009095 dimer interface [polypeptide binding]; other site 378806009096 interdomain contacts; other site 378806009097 partial ornithine binding site; other site 378806009098 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 378806009099 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 378806009100 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 378806009101 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 378806009102 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 378806009103 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 378806009104 active site 378806009105 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 378806009106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806009107 Helix-turn-helix domain; Region: HTH_18; pfam12833 378806009108 Prostaglandin dehydrogenases; Region: PGDH; cd05288 378806009109 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 378806009110 NAD(P) binding site [chemical binding]; other site 378806009111 substrate binding site [chemical binding]; other site 378806009112 dimer interface [polypeptide binding]; other site 378806009113 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 378806009114 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 378806009115 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 378806009116 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 378806009117 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 378806009118 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806009119 putative sugar binding sites [chemical binding]; other site 378806009120 Q-X-W motif; other site 378806009121 Protein of unknown function (DUF466); Region: DUF466; cl01082 378806009122 Carbon starvation protein CstA; Region: CstA; cl00856 378806009123 Uncharacterized conserved protein [Function unknown]; Region: COG4715 378806009124 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378806009125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806009126 ATP binding site [chemical binding]; other site 378806009127 putative Mg++ binding site [ion binding]; other site 378806009128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806009129 nucleotide binding region [chemical binding]; other site 378806009130 ATP-binding site [chemical binding]; other site 378806009131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806009132 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 378806009133 active site 378806009134 catalytic triad [active] 378806009135 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806009136 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 378806009137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806009138 dimer interface [polypeptide binding]; other site 378806009139 phosphorylation site [posttranslational modification] 378806009140 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 378806009141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806009142 ATP binding site [chemical binding]; other site 378806009143 Mg2+ binding site [ion binding]; other site 378806009144 G-X-G motif; other site 378806009145 Response regulator receiver domain; Region: Response_reg; pfam00072 378806009146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806009147 active site 378806009148 phosphorylation site [posttranslational modification] 378806009149 intermolecular recognition site; other site 378806009150 dimerization interface [polypeptide binding]; other site 378806009151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806009152 dimer interface [polypeptide binding]; other site 378806009153 phosphorylation site [posttranslational modification] 378806009154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806009155 ATP binding site [chemical binding]; other site 378806009156 Mg2+ binding site [ion binding]; other site 378806009157 G-X-G motif; other site 378806009158 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 378806009159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806009160 S-adenosylmethionine binding site [chemical binding]; other site 378806009161 RecD/TraA family; Region: recD_rel; TIGR01448 378806009162 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 378806009163 MatE; Region: MatE; pfam01554 378806009164 MatE; Region: MatE; pfam01554 378806009165 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806009166 Putative esterase; Region: Esterase; pfam00756 378806009167 EamA-like transporter family; Region: EamA; cl01037 378806009168 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 378806009169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806009170 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 378806009171 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 378806009172 active site 378806009173 dimer interface [polypeptide binding]; other site 378806009174 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 378806009175 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 378806009176 active site 378806009177 FMN binding site [chemical binding]; other site 378806009178 substrate binding site [chemical binding]; other site 378806009179 3Fe-4S cluster binding site [ion binding]; other site 378806009180 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 378806009181 domain interface; other site 378806009182 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 378806009183 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 378806009184 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 378806009185 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806009186 YeeE/YedE family (DUF395); Region: DUF395; cl01018 378806009187 YeeE/YedE family (DUF395); Region: DUF395; cl01018 378806009188 CsbD-like; Region: CsbD; cl01272 378806009189 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806009190 ligand binding site [chemical binding]; other site 378806009191 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 378806009192 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 378806009193 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806009194 active site 378806009195 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 378806009196 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 378806009197 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 378806009198 active site 378806009199 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 378806009200 Ligand Binding Site [chemical binding]; other site 378806009201 Molecular Tunnel; other site 378806009202 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 378806009203 hypothetical protein; Provisional; Region: PRK06154 378806009204 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 378806009205 PYR/PP interface [polypeptide binding]; other site 378806009206 dimer interface [polypeptide binding]; other site 378806009207 TPP binding site [chemical binding]; other site 378806009208 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378806009209 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 378806009210 TPP-binding site; other site 378806009211 dimer interface [polypeptide binding]; other site 378806009212 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 378806009213 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806009214 large tegument protein UL36; Provisional; Region: PHA03247 378806009215 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 378806009216 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806009217 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 378806009218 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 378806009219 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 378806009220 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 378806009221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806009222 FAD binding domain; Region: FAD_binding_3; pfam01494 378806009223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806009224 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 378806009225 hypothetical protein; Validated; Region: PRK05868 378806009226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806009227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806009228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806009229 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 378806009230 dimerization interface [polypeptide binding]; other site 378806009231 substrate binding pocket [chemical binding]; other site 378806009232 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 378806009233 Ca2+ binding site [ion binding]; other site 378806009234 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 378806009235 hypothetical protein; Provisional; Region: PRK08317 378806009236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806009237 S-adenosylmethionine binding site [chemical binding]; other site 378806009238 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 378806009239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806009240 non-specific DNA binding site [nucleotide binding]; other site 378806009241 salt bridge; other site 378806009242 sequence-specific DNA binding site [nucleotide binding]; other site 378806009243 Transposase domain (DUF772); Region: DUF772; cl12084 378806009244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806009245 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806009246 active site 378806009247 ATP binding site [chemical binding]; other site 378806009248 substrate binding site [chemical binding]; other site 378806009249 activation loop (A-loop); other site 378806009250 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806009251 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806009252 Integrase core domain; Region: rve; cl01316 378806009253 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 378806009254 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 378806009255 putative active site [active] 378806009256 putative NTP binding site [chemical binding]; other site 378806009257 putative nucleic acid binding site [nucleotide binding]; other site 378806009258 Transposase domain (DUF772); Region: DUF772; cl12084 378806009259 Superfamily II helicase [General function prediction only]; Region: COG1204 378806009260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806009261 nucleotide binding region [chemical binding]; other site 378806009262 ATP-binding site [chemical binding]; other site 378806009263 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 378806009264 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 378806009265 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 378806009266 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 378806009267 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806009268 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806009269 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 378806009270 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806009271 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 378806009272 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 378806009273 putative active site [active] 378806009274 putative metal binding site [ion binding]; other site 378806009275 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 378806009276 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806009277 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806009278 phosphopeptide binding site; other site 378806009279 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806009280 phosphopeptide binding site; other site 378806009281 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 378806009282 domain; Region: GreA_GreB_N; pfam03449 378806009283 C-term; Region: GreA_GreB; pfam01272 378806009284 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 378806009285 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 378806009286 ssDNA binding site; other site 378806009287 generic binding surface II; other site 378806009288 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806009289 ATP binding site [chemical binding]; other site 378806009290 putative Mg++ binding site [ion binding]; other site 378806009291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806009292 nucleotide binding region [chemical binding]; other site 378806009293 ATP-binding site [chemical binding]; other site 378806009294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806009295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806009296 S-adenosylmethionine binding site [chemical binding]; other site 378806009297 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 378806009298 threonine synthase; Region: PLN02569 378806009299 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 378806009300 homodimer interface [polypeptide binding]; other site 378806009301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806009302 catalytic residue [active] 378806009303 thymidylate kinase; Region: DTMP_kinase; TIGR00041 378806009304 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 378806009305 TMP-binding site; other site 378806009306 ATP-binding site [chemical binding]; other site 378806009307 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 378806009308 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 378806009309 MPT binding site; other site 378806009310 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806009311 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806009312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806009313 binding surface 378806009314 TPR motif; other site 378806009315 putative oxidoreductase; Provisional; Region: PRK11579 378806009316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806009317 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 378806009318 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 378806009319 putative active site [active] 378806009320 nucleotide binding site [chemical binding]; other site 378806009321 nudix motif; other site 378806009322 putative metal binding site [ion binding]; other site 378806009323 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 378806009324 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 378806009325 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 378806009326 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806009327 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806009328 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238 378806009329 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 378806009330 metal binding site [ion binding]; metal-binding site 378806009331 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806009332 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 378806009333 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_1_2; cd06239 378806009334 putative active site [active] 378806009335 Zn-binding site [ion binding]; other site 378806009336 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 378806009337 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 378806009338 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 378806009339 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806009340 active site 378806009341 ATP binding site [chemical binding]; other site 378806009342 substrate binding site [chemical binding]; other site 378806009343 activation loop (A-loop); other site 378806009344 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 378806009345 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806009346 active site 378806009347 ATP binding site [chemical binding]; other site 378806009348 substrate binding site [chemical binding]; other site 378806009349 activation loop (A-loop); other site 378806009350 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 378806009351 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 378806009352 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 378806009353 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 378806009354 classical (c) SDRs; Region: SDR_c; cd05233 378806009355 NAD(P) binding site [chemical binding]; other site 378806009356 active site 378806009357 tyramine oxidase; Provisional; Region: tynA; PRK11504 378806009358 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 378806009359 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 378806009360 potential frameshift: common BLAST hit: gi|220915455|ref|YP_002490759.1| transcriptional regulator, LysR family 378806009361 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806009362 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 378806009363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806009364 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 378806009365 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806009366 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 378806009367 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 378806009368 putative metal binding site [ion binding]; other site 378806009369 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 378806009370 putative metal binding site [ion binding]; other site 378806009371 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 378806009372 putative metal binding site [ion binding]; other site 378806009373 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 378806009374 putative metal binding site [ion binding]; other site 378806009375 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 378806009376 Transposase domain (DUF772); Region: DUF772; cl12084 378806009377 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806009378 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009379 active site 378806009380 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009381 PKS_DH; Region: PKS_DH; smart00826 378806009382 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806009383 putative NADP binding site [chemical binding]; other site 378806009384 active site 378806009385 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009386 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806009387 Thioesterase domain; Region: Thioesterase; pfam00975 378806009388 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806009389 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009390 active site 378806009391 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009392 PKS_DH; Region: PKS_DH; smart00826 378806009393 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806009394 putative NADP binding site [chemical binding]; other site 378806009395 active site 378806009396 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009397 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806009398 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009399 active site 378806009400 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009401 PKS_DH; Region: PKS_DH; smart00826 378806009402 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806009403 putative NADP binding site [chemical binding]; other site 378806009404 active site 378806009405 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009406 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009407 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806009408 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009409 active site 378806009410 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009411 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806009412 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009413 PKS_DH; Region: PKS_DH; smart00826 378806009414 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806009415 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806009416 putative NADP binding site [chemical binding]; other site 378806009417 active site 378806009418 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009419 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but...; Region: chitinase_glyco_hydro_19; cd00325 378806009420 putative sugar binding site [chemical binding]; other site 378806009421 catalytic residues [active] 378806009422 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 378806009423 domain; Region: Glyco_hydro_2; pfam00703 378806009424 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 378806009425 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806009426 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806009427 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 378806009428 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 378806009429 active sites [active] 378806009430 tetramer interface [polypeptide binding]; other site 378806009431 aspartate kinase; Reviewed; Region: PRK06635 378806009432 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 378806009433 putative nucleotide binding site [chemical binding]; other site 378806009434 putative catalytic residues [active] 378806009435 putative Mg ion binding site [ion binding]; other site 378806009436 putative aspartate binding site [chemical binding]; other site 378806009437 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 378806009438 putative allosteric regulatory site; other site 378806009439 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 378806009440 putative allosteric regulatory residue; other site 378806009441 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 378806009442 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 378806009443 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806009444 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 378806009445 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 378806009446 DXD motif; other site 378806009447 NlpC/P60 family; Region: NLPC_P60; cl11438 378806009448 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 378806009449 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806009450 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 378806009451 SCP-2 sterol transfer family; Region: SCP2; cl01225 378806009452 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 378806009453 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806009454 putative sugar binding sites [chemical binding]; other site 378806009455 Q-X-W motif; other site 378806009456 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but...; Region: chitinase_glyco_hydro_19; cd00325 378806009457 putative sugar binding site [chemical binding]; other site 378806009458 catalytic residues [active] 378806009459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806009460 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 378806009461 iron-sulfur cluster [ion binding]; other site 378806009462 [2Fe-2S] cluster binding site [ion binding]; other site 378806009463 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806009464 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 378806009465 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 378806009466 DXD motif; other site 378806009467 kelch-like protein; Provisional; Region: PHA03098 378806009468 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 378806009469 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 378806009470 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 378806009471 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 378806009472 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009473 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009474 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806009475 active site 378806009476 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806009477 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009478 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806009479 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009480 PKS_DH; Region: PKS_DH; smart00826 378806009481 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806009482 putative NADP binding site [chemical binding]; other site 378806009483 active site 378806009484 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009485 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009486 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806009487 active site 378806009488 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806009489 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009490 PKS_DH; Region: PKS_DH; smart00826 378806009491 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806009492 putative NADP binding site [chemical binding]; other site 378806009493 active site 378806009494 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009495 Condensation domain; Region: Condensation; cl09290 378806009496 Nonribosomal peptide synthase; Region: NRPS; pfam08415 378806009497 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806009498 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009499 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009500 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 378806009501 putative FMN binding site [chemical binding]; other site 378806009502 NADPH bind site [chemical binding]; other site 378806009503 Condensation domain; Region: Condensation; cl09290 378806009504 Nonribosomal peptide synthase; Region: NRPS; pfam08415 378806009505 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009506 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806009507 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009508 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 378806009509 NADPH bind site [chemical binding]; other site 378806009510 putative FMN binding site [chemical binding]; other site 378806009511 peptide synthase; Validated; Region: PRK05691 378806009512 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009513 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806009514 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009515 active site 378806009516 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009517 PKS_DH; Region: PKS_DH; smart00826 378806009518 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806009519 putative NADP binding site [chemical binding]; other site 378806009520 active site 378806009521 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009522 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009523 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806009524 active site 378806009525 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806009526 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009527 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 378806009528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806009529 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806009530 putative NADP binding site [chemical binding]; other site 378806009531 active site 378806009532 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009533 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009534 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806009535 active site 378806009536 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806009537 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009538 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 378806009539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806009540 S-adenosylmethionine binding site [chemical binding]; other site 378806009541 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009542 Condensation domain; Region: Condensation; cl09290 378806009543 peptide synthase; Provisional; Region: PRK12467 378806009544 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 378806009545 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 378806009546 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 378806009547 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009548 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009549 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806009550 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 378806009551 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 378806009552 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 378806009553 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 378806009554 active site 378806009555 NTP binding site [chemical binding]; other site 378806009556 metal binding triad [ion binding]; metal-binding site 378806009557 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 378806009558 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 378806009559 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 378806009560 Ligand Binding Site [chemical binding]; other site 378806009561 Sporulation related domain; Region: SPOR; cl10051 378806009562 Cupin domain; Region: Cupin_2; cl09118 378806009563 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 378806009564 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806009565 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 378806009566 NAD binding site [chemical binding]; other site 378806009567 putative substrate binding site 2 [chemical binding]; other site 378806009568 putative substrate binding site 1 [chemical binding]; other site 378806009569 active site 378806009570 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806009571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806009572 NAD(P) binding site [chemical binding]; other site 378806009573 active site 378806009574 GTP-binding protein LepA; Provisional; Region: PRK05433 378806009575 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 378806009576 G1 box; other site 378806009577 putative GEF interaction site [polypeptide binding]; other site 378806009578 GTP/Mg2+ binding site [chemical binding]; other site 378806009579 Switch I region; other site 378806009580 G2 box; other site 378806009581 G3 box; other site 378806009582 Switch II region; other site 378806009583 G4 box; other site 378806009584 G5 box; other site 378806009585 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 378806009586 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 378806009587 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 378806009588 signal peptidase I; Provisional; Region: PRK10861 378806009589 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 378806009590 Catalytic site [active] 378806009591 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 378806009592 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 378806009593 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 378806009594 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 378806009595 dihydroorotase; Validated; Region: pyrC; PRK09357 378806009596 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806009597 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 378806009598 active site 378806009599 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 378806009600 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 378806009601 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 378806009602 catalytic site [active] 378806009603 subunit interface [polypeptide binding]; other site 378806009604 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 378806009605 pyruvate kinase; Provisional; Region: PRK05826 378806009606 domain interfaces; other site 378806009607 active site 378806009608 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 378806009609 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 378806009610 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009611 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009612 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 378806009613 Citrate synthase; Region: Citrate_synt; pfam00285 378806009614 oxalacetate binding site [chemical binding]; other site 378806009615 citrylCoA binding site [chemical binding]; other site 378806009616 coenzyme A binding site [chemical binding]; other site 378806009617 catalytic triad [active] 378806009618 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 378806009619 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 378806009620 putative active site [active] 378806009621 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 378806009622 active site 378806009623 NAD binding site [chemical binding]; other site 378806009624 metal binding site [ion binding]; metal-binding site 378806009625 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 378806009626 Tetramer interface [polypeptide binding]; other site 378806009627 Active site [active] 378806009628 FMN-binding site [chemical binding]; other site 378806009629 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 378806009630 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 378806009631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806009632 Active site [active] 378806009633 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 378806009634 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 378806009635 dimer interface [polypeptide binding]; other site 378806009636 tetramer interface [polypeptide binding]; other site 378806009637 PYR/PP interface [polypeptide binding]; other site 378806009638 TPP binding site [chemical binding]; other site 378806009639 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 378806009640 TPP-binding site; other site 378806009641 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 378806009642 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 378806009643 UbiA prenyltransferase family; Region: UbiA; cl00337 378806009644 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 378806009645 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion...; Region: enolase_like; cl14814 378806009646 metal binding site [ion binding]; metal-binding site 378806009647 substrate binding pocket [chemical binding]; other site 378806009648 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 378806009649 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009650 isocitrate dehydrogenase; Validated; Region: PRK07362 378806009651 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 378806009652 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 378806009653 malate dehydrogenase; Reviewed; Region: PRK06223 378806009654 dimer interface [polypeptide binding]; other site 378806009655 NAD(P) binding site [chemical binding]; other site 378806009656 tetramer (dimer of dimers) interface [polypeptide binding]; other site 378806009657 substrate binding site [chemical binding]; other site 378806009658 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 378806009659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806009660 domain; Region: Succ_DH_flav_C; pfam02910 378806009661 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 378806009662 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 378806009663 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 378806009664 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806009665 CoA-ligase; Region: Ligase_CoA; pfam00549 378806009666 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 378806009667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806009668 CoA-ligase; Region: Ligase_CoA; pfam00549 378806009669 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 378806009670 active site 378806009671 multimer interface [polypeptide binding]; other site 378806009672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806009673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806009674 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806009675 dimerization interface [polypeptide binding]; other site 378806009676 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 378806009677 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 378806009678 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 378806009679 active site 378806009680 Isochorismatase family; Region: Isochorismatase; pfam00857 378806009681 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 378806009682 catalytic triad [active] 378806009683 dimer interface [polypeptide binding]; other site 378806009684 conserved cis-peptide bond; other site 378806009685 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 378806009686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806009687 FeS/SAM binding site; other site 378806009688 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 378806009689 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 378806009690 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 378806009691 RimM N-terminal domain; Region: RimM; pfam01782 378806009692 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 378806009693 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 378806009694 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 378806009695 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 378806009696 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 378806009697 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 378806009698 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806009699 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806009700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806009701 active site 378806009702 phosphorylation site [posttranslational modification] 378806009703 intermolecular recognition site; other site 378806009704 dimerization interface [polypeptide binding]; other site 378806009705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806009706 Walker A motif; other site 378806009707 ATP binding site [chemical binding]; other site 378806009708 Walker B motif; other site 378806009709 arginine finger; other site 378806009710 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806009711 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 378806009712 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 378806009713 diiron binding motif [ion binding]; other site 378806009714 MviN-like protein; Region: MVIN; pfam03023 378806009715 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 378806009716 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 378806009717 RNA binding site [nucleotide binding]; other site 378806009718 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 378806009719 RNA binding site [nucleotide binding]; other site 378806009720 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 378806009721 RNA binding site [nucleotide binding]; other site 378806009722 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 378806009723 RNA binding site [nucleotide binding]; other site 378806009724 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 378806009725 putative NAD(P) binding site [chemical binding]; other site 378806009726 active site 378806009727 polyphosphate kinase; Provisional; Region: PRK05443 378806009728 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 378806009729 putative domain interface [polypeptide binding]; other site 378806009730 putative active site [active] 378806009731 catalytic site [active] 378806009732 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 378806009733 putative domain interface [polypeptide binding]; other site 378806009734 putative active site [active] 378806009735 catalytic site [active] 378806009736 PEGA domain; Region: PEGA; pfam08308 378806009737 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806009738 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806009739 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 378806009740 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806009741 DNA binding site [nucleotide binding] 378806009742 Int/Topo IB signature motif; other site 378806009743 active site 378806009744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 378806009745 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 378806009746 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 378806009747 ATPase involved in DNA repair; Region: DUF3686; pfam12458 378806009748 MoxR-like ATPases [General function prediction only]; Region: COG0714 378806009749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806009750 Walker A motif; other site 378806009751 ATP binding site [chemical binding]; other site 378806009752 Walker B motif; other site 378806009753 arginine finger; other site 378806009754 Domain of unknown function (DUF336); Region: DUF336; cl01249 378806009755 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806009756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806009757 ATP binding site [chemical binding]; other site 378806009758 Mg2+ binding site [ion binding]; other site 378806009759 G-X-G motif; other site 378806009760 Uncharacterized conserved protein [Function unknown]; Region: COG3287 378806009761 FIST N domain; Region: FIST; pfam08495 378806009762 FIST C domain; Region: FIST_C; pfam10442 378806009763 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 378806009764 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 378806009765 Isochorismatase family; Region: Isochorismatase; pfam00857 378806009766 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 378806009767 catalytic triad [active] 378806009768 conserved cis-peptide bond; other site 378806009769 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 378806009770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806009771 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 378806009772 NAD(P) binding site [chemical binding]; other site 378806009773 active site 378806009774 metabolite-proton symporter; Region: 2A0106; TIGR00883 378806009775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806009776 putative substrate translocation pore; other site 378806009777 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806009778 Integrase core domain; Region: rve; cl01316 378806009779 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806009780 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806009781 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378806009782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806009783 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 378806009784 adenylate kinases; Region: adk; TIGR01351 378806009785 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 378806009786 AMP-binding site [chemical binding]; other site 378806009787 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 378806009788 Phosphotransferase enzyme family; Region: APH; pfam01636 378806009789 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806009790 active site 378806009791 ATP binding site [chemical binding]; other site 378806009792 substrate binding site [chemical binding]; other site 378806009793 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 378806009794 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 378806009795 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 378806009796 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 378806009797 protein binding site [polypeptide binding]; other site 378806009798 RecX family; Region: RecX; cl00936 378806009799 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 378806009800 catalytic residues [active] 378806009801 LysR family transcriptional regulator; Provisional; Region: PRK14997 378806009802 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 378806009803 putative effector binding pocket; other site 378806009804 dimerization interface [polypeptide binding]; other site 378806009805 von Willebrand factor; Region: vWF_A; pfam12450 378806009806 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 378806009807 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_subgroup; cd01465 378806009808 metal ion-dependent adhesion site (MIDAS); other site 378806009809 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 378806009810 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 378806009811 Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401 378806009812 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 378806009813 active site 378806009814 Zn binding site [ion binding]; other site 378806009815 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 378806009816 DNA-binding site [nucleotide binding]; DNA binding site 378806009817 RNA-binding motif; other site 378806009818 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806009819 Zn binding site [ion binding]; other site 378806009820 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 378806009821 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 378806009822 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 378806009823 PilZ domain; Region: PilZ; cl01260 378806009824 Protein of unknown function, DUF400; Region: DUF400; cl01141 378806009825 PEGA domain; Region: PEGA; pfam08308 378806009826 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 378806009827 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 378806009828 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 378806009829 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 378806009830 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 378806009831 active site 378806009832 dimer interface [polypeptide binding]; other site 378806009833 motif 1; other site 378806009834 motif 2; other site 378806009835 motif 3; other site 378806009836 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 378806009837 anticodon binding site; other site 378806009838 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 378806009839 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 378806009840 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 378806009841 23S rRNA binding site [nucleotide binding]; other site 378806009842 L21 binding site [polypeptide binding]; other site 378806009843 L13 binding site [polypeptide binding]; other site 378806009844 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 378806009845 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 378806009846 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 378806009847 dimer interface [polypeptide binding]; other site 378806009848 motif 1; other site 378806009849 active site 378806009850 motif 2; other site 378806009851 motif 3; other site 378806009852 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 378806009853 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 378806009854 putative tRNA-binding site [nucleotide binding]; other site 378806009855 B3/4 domain; Region: B3_4; cl11458 378806009856 tRNA synthetase B5 domain; Region: B5; cl08394 378806009857 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 378806009858 dimer interface [polypeptide binding]; other site 378806009859 motif 1; other site 378806009860 motif 3; other site 378806009861 motif 2; other site 378806009862 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 378806009863 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 378806009864 IHF dimer interface [polypeptide binding]; other site 378806009865 IHF - DNA interface [nucleotide binding]; other site 378806009866 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 378806009867 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 378806009868 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806009869 Walker A/P-loop; other site 378806009870 ATP binding site [chemical binding]; other site 378806009871 Q-loop/lid; other site 378806009872 ABC transporter signature motif; other site 378806009873 Walker B; other site 378806009874 D-loop; other site 378806009875 H-loop/switch region; other site 378806009876 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 378806009877 Beta-lactamase; Region: Beta-lactamase; cl01009 378806009878 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 378806009879 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 378806009880 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 378806009881 FAD binding domain; Region: FAD_binding_4; pfam01565 378806009882 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 378806009883 Domain of unknown function (DUF697); Region: DUF697; cl12064 378806009884 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 378806009885 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 378806009886 Cupin superfamily protein; Region: Cupin_4; pfam08007 378806009887 Cupin superfamily protein; Region: Cupin_4; pfam08007 378806009888 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 378806009889 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 378806009890 active site 378806009891 zinc binding site [ion binding]; other site 378806009892 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 378806009893 Active site serine [active] 378806009894 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 378806009895 substrate binding pocket [chemical binding]; other site 378806009896 chain length determination region; other site 378806009897 substrate-Mg2+ binding site; other site 378806009898 catalytic residues [active] 378806009899 aspartate-rich region 1; other site 378806009900 active site lid residues [active] 378806009901 aspartate-rich region 2; other site 378806009902 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 378806009903 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 378806009904 B12 binding site [chemical binding]; other site 378806009905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806009906 FtsX-like permease family; Region: FtsX; pfam02687 378806009907 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806009908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806009909 NAD(P) binding site [chemical binding]; other site 378806009910 active site 378806009911 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806009912 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806009913 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 378806009914 FtsX-like permease family; Region: FtsX; pfam02687 378806009915 Condensation domain; Region: Condensation; cl09290 378806009916 peptide synthase; Provisional; Region: PRK12316 378806009917 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009918 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009919 Condensation domain; Region: Condensation; cl09290 378806009920 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 378806009921 Condensation domain; Region: Condensation; cl09290 378806009922 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009923 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009924 Condensation domain; Region: Condensation; cl09290 378806009925 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009926 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009927 Condensation domain; Region: Condensation; cl09290 378806009928 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 378806009929 peptide synthase; Provisional; Region: PRK12467 378806009930 Condensation domain; Region: Condensation; cl09290 378806009931 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009932 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009933 Condensation domain; Region: Condensation; cl09290 378806009934 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009935 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009936 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806009937 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806009938 active site 378806009939 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806009940 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806009941 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 378806009942 putative NADP binding site [chemical binding]; other site 378806009943 active site 378806009944 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009945 Condensation domain; Region: Condensation; cl09290 378806009946 peptide synthase; Provisional; Region: PRK12316 378806009947 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009948 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009949 Condensation domain; Region: Condensation; cl09290 378806009950 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806009951 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009952 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009953 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009954 Condensation domain; Region: Condensation; cl09290 378806009955 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806009956 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009957 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806009958 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806009959 Condensation domain; Region: Condensation; cl09290 378806009960 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806009961 H+ Antiporter protein; Region: 2A0121; TIGR00900 378806009962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806009963 amidase; Provisional; Region: PRK06828 378806009964 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 378806009965 Predicted membrane protein [Function unknown]; Region: COG1289 378806009966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806009967 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 378806009968 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 378806009969 substrate binding pocket [chemical binding]; other site 378806009970 chain length determination region; other site 378806009971 substrate-Mg2+ binding site; other site 378806009972 catalytic residues [active] 378806009973 aspartate-rich region 1; other site 378806009974 active site lid residues [active] 378806009975 aspartate-rich region 2; other site 378806009976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806009977 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 378806009978 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 378806009979 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 378806009980 active site 378806009981 metal binding site [ion binding]; metal-binding site 378806009982 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 378806009983 glycogen branching enzyme; Provisional; Region: PRK05402 378806009984 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 378806009985 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 378806009986 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806009987 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 378806009988 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 378806009989 trehalose synthase; Region: treS_nterm; TIGR02456 378806009990 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806009991 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 378806009992 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806009993 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806009994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806009995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806009996 DNA binding residues [nucleotide binding] 378806009997 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806009998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806009999 homodimer interface [polypeptide binding]; other site 378806010000 catalytic residue [active] 378806010001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806010002 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 378806010003 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 378806010004 SelR domain; Region: SelR; cl00369 378806010005 catalase; Region: PLN02609 378806010006 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 378806010007 tetramer interface [polypeptide binding]; other site 378806010008 heme binding pocket [chemical binding]; other site 378806010009 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 378806010010 domain interactions; other site 378806010011 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 378806010012 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 378806010013 metal binding site 2 [ion binding]; metal-binding site 378806010014 putative DNA binding helix; other site 378806010015 metal binding site 1 [ion binding]; metal-binding site 378806010016 dimer interface [polypeptide binding]; other site 378806010017 structural Zn2+ binding site [ion binding]; other site 378806010018 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 378806010019 catalytic residues [active] 378806010020 Septum formation initiator; Region: DivIC; cl11433 378806010021 GAF domain; Region: GAF; cl00853 378806010022 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806010023 GAF domain; Region: GAF; cl00853 378806010024 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806010025 metal binding site [ion binding]; metal-binding site 378806010026 active site 378806010027 I-site; other site 378806010028 MBOAT family; Region: MBOAT; cl00738 378806010029 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378806010030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806010031 Outer membrane efflux protein; Region: OEP; pfam02321 378806010032 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 378806010033 Outer membrane efflux protein; Region: OEP; pfam02321 378806010034 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806010035 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 378806010036 hypothetical protein; Provisional; Region: PRK08317 378806010037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806010038 acyl-CoA synthetase; Validated; Region: PRK05850 378806010039 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806010040 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806010041 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806010042 Condensation domain; Region: Condensation; cl09290 378806010043 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806010044 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806010045 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 378806010046 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 378806010047 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 378806010048 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806010049 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806010050 Penicillin amidase; Region: Penicil_amidase; pfam01804 378806010051 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 378806010052 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_CA; cd01936 378806010053 active site 378806010054 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 378806010055 Cupin superfamily protein; Region: Cupin_4; pfam08007 378806010056 H+ Antiporter protein; Region: 2A0121; TIGR00900 378806010057 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806010058 Thioesterase domain; Region: Thioesterase; pfam00975 378806010059 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 378806010060 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806010061 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806010062 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806010063 active site 378806010064 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806010065 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806010066 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806010067 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806010068 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806010069 active site 378806010070 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806010071 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806010072 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 378806010073 putative NADP binding site [chemical binding]; other site 378806010074 active site 378806010075 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806010076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806010077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806010078 Protein kinase domain; Region: Pkinase; pfam00069 378806010079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806010080 active site 378806010081 ATP binding site [chemical binding]; other site 378806010082 substrate binding site [chemical binding]; other site 378806010083 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806010084 substrate binding site [chemical binding]; other site 378806010085 activation loop (A-loop); other site 378806010086 activation loop (A-loop); other site 378806010087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378806010088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010089 active site 378806010090 phosphorylation site [posttranslational modification] 378806010091 intermolecular recognition site; other site 378806010092 dimerization interface [polypeptide binding]; other site 378806010093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806010094 DNA binding residues [nucleotide binding] 378806010095 dimerization interface [polypeptide binding]; other site 378806010096 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806010097 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806010098 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806010099 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806010100 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806010101 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806010102 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806010103 active site 378806010104 Domain of unknown function DUF140; Region: DUF140; cl00510 378806010105 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 378806010106 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 378806010107 Walker A/P-loop; other site 378806010108 ATP binding site [chemical binding]; other site 378806010109 Q-loop/lid; other site 378806010110 ABC transporter signature motif; other site 378806010111 Walker B; other site 378806010112 D-loop; other site 378806010113 H-loop/switch region; other site 378806010114 mce related protein; Region: MCE; cl03606 378806010115 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 378806010116 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 378806010117 substrate binding site [chemical binding]; other site 378806010118 ATP binding site [chemical binding]; other site 378806010119 PilZ domain; Region: PilZ; cl01260 378806010120 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806010121 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 378806010122 active site 378806010123 metal binding site [ion binding]; metal-binding site 378806010124 chromosome segregation protein; Provisional; Region: PRK02224 378806010125 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 378806010126 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 378806010127 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 378806010128 dimer interface [polypeptide binding]; other site 378806010129 motif 1; other site 378806010130 active site 378806010131 motif 2; other site 378806010132 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 378806010133 anticodon binding site; other site 378806010134 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806010135 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806010136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806010137 ATP binding site [chemical binding]; other site 378806010138 Mg2+ binding site [ion binding]; other site 378806010139 G-X-G motif; other site 378806010140 Response regulator receiver domain; Region: Response_reg; pfam00072 378806010141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010142 active site 378806010143 phosphorylation site [posttranslational modification] 378806010144 intermolecular recognition site; other site 378806010145 dimerization interface [polypeptide binding]; other site 378806010146 metabolite-proton symporter; Region: 2A0106; TIGR00883 378806010147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806010148 putative substrate translocation pore; other site 378806010149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806010150 putative transporter; Provisional; Region: PRK10504 378806010151 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 378806010152 domain; Region: Glyco_hydro_2; pfam00703 378806010153 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 378806010154 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806010155 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806010156 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806010157 IPP transferase; Region: IPPT; cl00403 378806010158 Response regulator receiver domain; Region: Response_reg; pfam00072 378806010159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010160 active site 378806010161 phosphorylation site [posttranslational modification] 378806010162 intermolecular recognition site; other site 378806010163 dimerization interface [polypeptide binding]; other site 378806010164 Response regulator receiver domain; Region: Response_reg; pfam00072 378806010165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010166 active site 378806010167 phosphorylation site [posttranslational modification] 378806010168 intermolecular recognition site; other site 378806010169 dimerization interface [polypeptide binding]; other site 378806010170 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806010171 metal binding site [ion binding]; metal-binding site 378806010172 active site 378806010173 I-site; other site 378806010174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806010175 TPR motif; other site 378806010176 binding surface 378806010177 Response regulator receiver domain; Region: Response_reg; pfam00072 378806010178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010179 active site 378806010180 phosphorylation site [posttranslational modification] 378806010181 intermolecular recognition site; other site 378806010182 dimerization interface [polypeptide binding]; other site 378806010183 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 378806010184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806010185 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 378806010186 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 378806010187 putative active site; other site 378806010188 catalytic residue [active] 378806010189 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 378806010190 Outer membrane efflux protein; Region: OEP; pfam02321 378806010191 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 378806010192 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 378806010193 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 378806010194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806010195 NAD(P) binding site [chemical binding]; other site 378806010196 active site 378806010197 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 378806010198 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806010199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806010200 catalytic residue [active] 378806010201 hypothetical protein; Provisional; Region: PRK08912 378806010202 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806010203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806010204 homodimer interface [polypeptide binding]; other site 378806010205 catalytic residue [active] 378806010206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806010207 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 378806010208 active site 378806010209 catalytic residues [active] 378806010210 metal binding site [ion binding]; metal-binding site 378806010211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806010212 NAD(P) binding site [chemical binding]; other site 378806010213 active site 378806010214 potential frameshift: common BLAST hit: gi|220910734|ref|YP_002486044.1| transposase IS66 378806010215 Integrase core domain; Region: rve; cl01316 378806010216 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806010217 Integrase core domain; Region: rve; cl01316 378806010218 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806010219 active site 378806010220 ATP binding site [chemical binding]; other site 378806010221 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806010222 substrate binding site [chemical binding]; other site 378806010223 activation loop (A-loop); other site 378806010224 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806010225 conserved hypothetical protein; Region: TIGR02231 378806010226 conserved hypothetical protein; Region: TIGR02231 378806010227 conserved hypothetical protein; Region: TIGR02231 378806010228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806010229 S-adenosylmethionine binding site [chemical binding]; other site 378806010230 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806010231 putative catalytic site [active] 378806010232 putative metal binding site [ion binding]; other site 378806010233 putative phosphate binding site [ion binding]; other site 378806010234 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 378806010235 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 378806010236 tRNA; other site 378806010237 putative tRNA binding site [nucleotide binding]; other site 378806010238 putative NADP binding site [chemical binding]; other site 378806010239 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 378806010240 DoxX; Region: DoxX; cl00976 378806010241 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 378806010242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010243 active site 378806010244 phosphorylation site [posttranslational modification] 378806010245 intermolecular recognition site; other site 378806010246 dimerization interface [polypeptide binding]; other site 378806010247 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806010248 active site 378806010249 ATP binding site [chemical binding]; other site 378806010250 substrate binding site [chemical binding]; other site 378806010251 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 378806010252 activation loop (A-loop); other site 378806010253 cyclase homology domain; Region: CHD; cd07302 378806010254 nucleotidyl binding site; other site 378806010255 metal binding site [ion binding]; metal-binding site 378806010256 dimer interface [polypeptide binding]; other site 378806010257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010258 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806010259 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806010260 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 378806010261 active site 378806010262 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 378806010263 dimer interface [polypeptide binding]; other site 378806010264 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 378806010265 Ligand Binding Site [chemical binding]; other site 378806010266 Molecular Tunnel; other site 378806010267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806010268 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806010269 Protein of unknown function (DUF692); Region: DUF692; cl01263 378806010270 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806010271 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 378806010272 active site 378806010273 TDP-binding site; other site 378806010274 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 378806010275 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 378806010276 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806010277 putative sugar binding sites [chemical binding]; other site 378806010278 Q-X-W motif; other site 378806010279 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806010280 putative sugar binding sites [chemical binding]; other site 378806010281 Q-X-W motif; other site 378806010282 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806010283 Tim44-like domain; Region: Tim44; cl09208 378806010284 tellurium resistance terB-like protein; Region: terB_like; cd07177 378806010285 metal binding site [ion binding]; metal-binding site 378806010286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806010287 enoyl-CoA hydratase; Provisional; Region: PRK07657 378806010288 substrate binding site [chemical binding]; other site 378806010289 oxyanion hole (OAH) forming residues; other site 378806010290 trimer interface [polypeptide binding]; other site 378806010291 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 378806010292 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 378806010293 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 378806010294 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 378806010295 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 378806010296 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 378806010297 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 378806010298 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806010299 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 378806010300 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 378806010301 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 378806010302 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 378806010303 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806010304 N-terminal plug; other site 378806010305 ligand-binding site [chemical binding]; other site 378806010306 GAF domain; Region: GAF; cl00853 378806010307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806010308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806010309 dimer interface [polypeptide binding]; other site 378806010310 phosphorylation site [posttranslational modification] 378806010311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806010312 ATP binding site [chemical binding]; other site 378806010313 Mg2+ binding site [ion binding]; other site 378806010314 G-X-G motif; other site 378806010315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010316 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 378806010317 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010319 Walker A motif; other site 378806010320 ATP binding site [chemical binding]; other site 378806010321 Walker B motif; other site 378806010322 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010323 Walker A motif; other site 378806010324 Response regulator receiver domain; Region: Response_reg; pfam00072 378806010325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010326 active site 378806010327 phosphorylation site [posttranslational modification] 378806010328 intermolecular recognition site; other site 378806010329 dimerization interface [polypeptide binding]; other site 378806010330 Secretory lipase; Region: LIP; pfam03583 378806010331 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 378806010332 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 378806010333 putative dimer interface [polypeptide binding]; other site 378806010334 Epoxide hydrolase N terminus; Region: EHN; pfam06441 378806010335 haloalkane dehalogenase; Provisional; Region: PRK00870 378806010336 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 378806010337 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 378806010338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806010339 putative substrate translocation pore; other site 378806010340 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 378806010341 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 378806010342 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 378806010343 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806010344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806010345 active site 378806010346 ribonuclease III; Reviewed; Region: rnc; PRK00102 378806010347 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 378806010348 dimerization interface [polypeptide binding]; other site 378806010349 active site 378806010350 metal binding site [ion binding]; metal-binding site 378806010351 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 378806010352 dsRNA binding site [nucleotide binding]; other site 378806010353 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 378806010354 active site 378806010355 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 378806010356 active site 378806010357 GTPase Era; Reviewed; Region: era; PRK00089 378806010358 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 378806010359 G1 box; other site 378806010360 GTP/Mg2+ binding site [chemical binding]; other site 378806010361 Switch I region; other site 378806010362 G2 box; other site 378806010363 Switch II region; other site 378806010364 G3 box; other site 378806010365 G4 box; other site 378806010366 G5 box; other site 378806010367 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 378806010368 GTP-binding protein Der; Reviewed; Region: PRK00093 378806010369 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 378806010370 G1 box; other site 378806010371 GTP/Mg2+ binding site [chemical binding]; other site 378806010372 Switch I region; other site 378806010373 G2 box; other site 378806010374 Switch II region; other site 378806010375 G3 box; other site 378806010376 G4 box; other site 378806010377 G5 box; other site 378806010378 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 378806010379 G1 box; other site 378806010380 GTP/Mg2+ binding site [chemical binding]; other site 378806010381 Switch I region; other site 378806010382 G2 box; other site 378806010383 G3 box; other site 378806010384 Switch II region; other site 378806010385 G4 box; other site 378806010386 G5 box; other site 378806010387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 378806010388 binding surface 378806010389 TPR motif; other site 378806010390 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 378806010391 Trp docking motif; other site 378806010392 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 378806010393 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 378806010394 active site 378806010395 8-oxo-dGMP binding site [chemical binding]; other site 378806010396 nudix motif; other site 378806010397 metal binding site [ion binding]; metal-binding site 378806010398 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 378806010399 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 378806010400 Peptidase S46; Region: Peptidase_S46; pfam10459 378806010401 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 378806010402 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806010403 substrate binding site [chemical binding]; other site 378806010404 oxyanion hole (OAH) forming residues; other site 378806010405 trimer interface [polypeptide binding]; other site 378806010406 GMP synthase; Reviewed; Region: guaA; PRK00074 378806010407 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 378806010408 AMP/PPi binding site [chemical binding]; other site 378806010409 candidate oxyanion hole; other site 378806010410 catalytic triad [active] 378806010411 potential glutamine specificity residues [chemical binding]; other site 378806010412 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 378806010413 ATP Binding subdomain [chemical binding]; other site 378806010414 Ligand Binding sites [chemical binding]; other site 378806010415 Dimerization subdomain; other site 378806010416 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 378806010417 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 378806010418 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 378806010419 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 378806010420 active site 378806010421 PilZ domain; Region: PilZ; cl01260 378806010422 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 378806010423 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 378806010424 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 378806010425 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806010426 ligand binding site [chemical binding]; other site 378806010427 flexible hinge region; other site 378806010428 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 378806010429 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 378806010430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806010431 FeS/SAM binding site; other site 378806010432 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 378806010433 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806010434 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806010435 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 378806010436 TRAM domain; Region: TRAM; cl01282 378806010437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806010438 S-adenosylmethionine binding site [chemical binding]; other site 378806010439 PilZ domain; Region: PilZ; cl01260 378806010440 Coenzyme A transferase; Region: CoA_trans; cl00773 378806010441 Coenzyme A transferase; Region: CoA_trans; cl00773 378806010442 putative acyltransferase; Provisional; Region: PRK05790 378806010443 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 378806010444 dimer interface [polypeptide binding]; other site 378806010445 active site 378806010446 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 378806010447 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 378806010448 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 378806010449 RNA binding site [nucleotide binding]; other site 378806010450 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 378806010451 RNA binding site [nucleotide binding]; other site 378806010452 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 378806010453 RNA binding site [nucleotide binding]; other site 378806010454 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 378806010455 RNA binding site [nucleotide binding]; other site 378806010456 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 378806010457 RNA binding site [nucleotide binding]; other site 378806010458 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 378806010459 RNA binding site [nucleotide binding]; other site 378806010460 domain interface; other site 378806010461 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806010462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806010463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806010464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806010465 dimer interface [polypeptide binding]; other site 378806010466 conserved gate region; other site 378806010467 putative PBP binding loops; other site 378806010468 ABC-ATPase subunit interface; other site 378806010469 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 378806010470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806010471 dimer interface [polypeptide binding]; other site 378806010472 conserved gate region; other site 378806010473 putative PBP binding loops; other site 378806010474 ABC-ATPase subunit interface; other site 378806010475 Protein kinase domain; Region: Pkinase; pfam00069 378806010476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806010477 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806010478 active site 378806010479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806010480 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 378806010481 FAD binding site [chemical binding]; other site 378806010482 homotetramer interface [polypeptide binding]; other site 378806010483 substrate binding pocket [chemical binding]; other site 378806010484 catalytic base [active] 378806010485 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 378806010486 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806010487 substrate binding site [chemical binding]; other site 378806010488 oxyanion hole (OAH) forming residues; other site 378806010489 trimer interface [polypeptide binding]; other site 378806010490 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 378806010491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806010492 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 378806010493 Domain of unknown function DUF59; Region: DUF59; cl00941 378806010494 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 378806010495 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 378806010496 Walker A motif; other site 378806010497 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 378806010498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806010499 S-adenosylmethionine binding site [chemical binding]; other site 378806010500 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 378806010501 chorismate binding enzyme; Region: Chorismate_bind; cl10555 378806010502 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 378806010503 oligomer interface [polypeptide binding]; other site 378806010504 tandem repeat interface [polypeptide binding]; other site 378806010505 active site residues [active] 378806010506 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 378806010507 tandem repeat interface [polypeptide binding]; other site 378806010508 oligomer interface [polypeptide binding]; other site 378806010509 active site residues [active] 378806010510 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 378806010511 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 378806010512 putative active site [active] 378806010513 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 378806010514 transmembrane helices; other site 378806010515 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 378806010516 putative hydrophobic ligand binding site [chemical binding]; other site 378806010517 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 378806010518 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806010519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806010520 binding surface 378806010521 TPR motif; other site 378806010522 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 378806010523 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806010524 ligand binding site [chemical binding]; other site 378806010525 flexible hinge region; other site 378806010526 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806010527 ligand binding site [chemical binding]; other site 378806010528 flexible hinge region; other site 378806010529 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806010530 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 378806010531 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378806010532 RNA binding surface [nucleotide binding]; other site 378806010533 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 378806010534 active site 378806010535 transcription termination factor Rho; Provisional; Region: PRK12678 378806010536 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 378806010537 ScpA/B protein; Region: ScpA_ScpB; cl00598 378806010538 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 378806010539 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 378806010540 active site 378806010541 HIGH motif; other site 378806010542 dimer interface [polypeptide binding]; other site 378806010543 KMSKS motif; other site 378806010544 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 378806010545 active site 378806010546 metal binding site [ion binding]; metal-binding site 378806010547 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 378806010548 active site 378806010549 catalytic residues [active] 378806010550 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 378806010551 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 378806010552 metal binding site [ion binding]; metal-binding site 378806010553 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806010554 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806010555 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 378806010556 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 378806010557 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 378806010558 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806010559 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cl08294 378806010560 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 378806010561 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 378806010562 Int/Topo IB signature motif; other site 378806010563 active site 378806010564 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 378806010565 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 378806010566 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 378806010567 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 378806010568 active site 378806010569 metal binding site [ion binding]; metal-binding site 378806010570 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806010571 active site 378806010572 ATP binding site [chemical binding]; other site 378806010573 substrate binding site [chemical binding]; other site 378806010574 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 378806010575 activation loop (A-loop); other site 378806010576 cyclase homology domain; Region: CHD; cd07302 378806010577 dimer interface [polypeptide binding]; other site 378806010578 nucleotidyl binding site; other site 378806010579 metal binding site [ion binding]; metal-binding site 378806010580 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010581 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 378806010582 MutS domain I; Region: MutS_I; pfam01624 378806010583 MutS domain II; Region: MutS_II; pfam05188 378806010584 MutS family domain IV; Region: MutS_IV; pfam05190 378806010585 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 378806010586 Walker A/P-loop; other site 378806010587 ATP binding site [chemical binding]; other site 378806010588 Q-loop/lid; other site 378806010589 ABC transporter signature motif; other site 378806010590 Walker B; other site 378806010591 D-loop; other site 378806010592 H-loop/switch region; other site 378806010593 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 378806010594 Beta-lactamase; Region: Beta-lactamase; cl01009 378806010595 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 378806010596 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806010597 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 378806010598 active site 378806010599 ATP binding site [chemical binding]; other site 378806010600 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 378806010601 putative C-terminal domain interface [polypeptide binding]; other site 378806010602 putative GSH binding site (G-site) [chemical binding]; other site 378806010603 putative dimer interface [polypeptide binding]; other site 378806010604 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 378806010605 dimer interface [polypeptide binding]; other site 378806010606 substrate binding pocket (H-site) [chemical binding]; other site 378806010607 N-terminal domain interface [polypeptide binding]; other site 378806010608 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806010609 active site 378806010610 ATP binding site [chemical binding]; other site 378806010611 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806010612 substrate binding site [chemical binding]; other site 378806010613 activation loop (A-loop); other site 378806010614 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 378806010615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010616 Walker A/P-loop; other site 378806010617 ATP binding site [chemical binding]; other site 378806010618 Q-loop/lid; other site 378806010619 ABC transporter signature motif; other site 378806010620 Walker B; other site 378806010621 D-loop; other site 378806010622 H-loop/switch region; other site 378806010623 GAF domain; Region: GAF; cl00853 378806010624 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 378806010625 PAS fold; Region: PAS_4; pfam08448 378806010626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806010627 putative active site [active] 378806010628 heme pocket [chemical binding]; other site 378806010629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806010630 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806010631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806010632 ATP binding site [chemical binding]; other site 378806010633 Mg2+ binding site [ion binding]; other site 378806010634 G-X-G motif; other site 378806010635 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 378806010636 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 378806010637 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 378806010638 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 378806010639 putative metal binding site [ion binding]; other site 378806010640 LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879 378806010641 PilZ domain; Region: PilZ; cl01260 378806010642 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 378806010643 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806010644 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 378806010645 Outer membrane efflux protein; Region: OEP; pfam02321 378806010646 Outer membrane efflux protein; Region: OEP; pfam02321 378806010647 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806010648 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806010649 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 378806010650 GAF domain; Region: GAF; cl00853 378806010651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806010652 Walker A motif; other site 378806010653 ATP binding site [chemical binding]; other site 378806010654 Walker B motif; other site 378806010655 arginine finger; other site 378806010656 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806010657 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 378806010658 TM-ABC transporter signature motif; other site 378806010659 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 378806010660 TM-ABC transporter signature motif; other site 378806010661 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 378806010662 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 378806010663 Walker A/P-loop; other site 378806010664 ATP binding site [chemical binding]; other site 378806010665 Q-loop/lid; other site 378806010666 ABC transporter signature motif; other site 378806010667 Walker B; other site 378806010668 D-loop; other site 378806010669 H-loop/switch region; other site 378806010670 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 378806010671 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 378806010672 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 378806010673 putative ligand binding site [chemical binding]; other site 378806010674 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 378806010675 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 378806010676 putative substrate binding site [chemical binding]; other site 378806010677 active site 378806010678 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 378806010679 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 378806010680 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 378806010681 putative substrate binding site [chemical binding]; other site 378806010682 active site 378806010683 galactokinase; Provisional; Region: PRK05101 378806010684 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 378806010685 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 378806010686 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 378806010687 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 378806010688 active site 378806010689 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378806010690 active site 378806010691 Protein kinase domain; Region: Pkinase; pfam00069 378806010692 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806010693 active site 378806010694 ATP binding site [chemical binding]; other site 378806010695 substrate binding site [chemical binding]; other site 378806010696 activation loop (A-loop); other site 378806010697 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806010698 phosphopeptide binding site; other site 378806010699 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806010700 GAF domain; Region: GAF; cl00853 378806010701 cyclase homology domain; Region: CHD; cd07302 378806010702 nucleotidyl binding site; other site 378806010703 metal binding site [ion binding]; metal-binding site 378806010704 dimer interface [polypeptide binding]; other site 378806010705 Uncharacterized conserved protein [Function unknown]; Region: COG0585 378806010706 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 378806010707 active site 378806010708 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806010709 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806010710 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806010711 DNA binding residues [nucleotide binding] 378806010712 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 378806010713 Protein of unknown function (DUF342); Region: DUF342; pfam03961 378806010714 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 378806010715 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 378806010716 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 378806010717 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 378806010718 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 378806010719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806010720 NAD(P) binding site [chemical binding]; other site 378806010721 active site 378806010722 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378806010723 Ligand Binding Site [chemical binding]; other site 378806010724 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378806010725 putative acyl-acceptor binding pocket; other site 378806010726 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806010727 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806010728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806010729 active site 378806010730 catalytic tetrad [active] 378806010731 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 378806010732 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806010733 GAF domain; Region: GAF; cl00853 378806010734 PAS fold; Region: PAS_4; pfam08448 378806010735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806010736 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806010737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806010738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806010739 ATP binding site [chemical binding]; other site 378806010740 Mg2+ binding site [ion binding]; other site 378806010741 G-X-G motif; other site 378806010742 WbqC-like protein family; Region: WbqC; pfam08889 378806010743 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 378806010744 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806010745 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806010746 active site 378806010747 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 378806010748 putative active site [active] 378806010749 catalytic triad [active] 378806010750 putative dimer interface [polypeptide binding]; other site 378806010751 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 378806010752 active site 378806010753 oxyanion hole [active] 378806010754 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 378806010755 active site 378806010756 oxyanion hole [active] 378806010757 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 378806010758 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 378806010759 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 378806010760 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 378806010761 generic binding surface I; other site 378806010762 generic binding surface II; other site 378806010763 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 378806010764 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 378806010765 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 378806010766 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 378806010767 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806010768 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806010769 DNA Polymerase Y-family; Region: PolY_like; cd03468 378806010770 active site 378806010771 DNA binding site [nucleotide binding] 378806010772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010773 Walker A motif; other site 378806010774 ATP binding site [chemical binding]; other site 378806010775 Walker B motif; other site 378806010776 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806010777 Found in ATP-dependent protease La (LON); Region: LON; cl01056 378806010778 ATP-dependent protease La; Region: lon; TIGR00763 378806010779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806010780 Walker A motif; other site 378806010781 ATP binding site [chemical binding]; other site 378806010782 Walker B motif; other site 378806010783 arginine finger; other site 378806010784 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 378806010785 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806010786 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806010787 active site 378806010788 ATP binding site [chemical binding]; other site 378806010789 substrate binding site [chemical binding]; other site 378806010790 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806010791 substrate binding site [chemical binding]; other site 378806010792 activation loop (A-loop); other site 378806010793 activation loop (A-loop); other site 378806010794 Predicted ATPase [General function prediction only]; Region: COG3899 378806010795 GAF domain; Region: GAF; cl00853 378806010796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806010797 dimer interface [polypeptide binding]; other site 378806010798 phosphorylation site [posttranslational modification] 378806010799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806010800 ATP binding site [chemical binding]; other site 378806010801 Mg2+ binding site [ion binding]; other site 378806010802 G-X-G motif; other site 378806010803 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 378806010804 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 378806010805 heme binding pocket [chemical binding]; other site 378806010806 Protein kinase; unclassified specificity; Region: STYKc; smart00221 378806010807 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806010808 active site 378806010809 ATP binding site [chemical binding]; other site 378806010810 substrate binding site [chemical binding]; other site 378806010811 activation loop (A-loop); other site 378806010812 Predicted membrane protein [Function unknown]; Region: COG4270 378806010813 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 378806010814 heme binding pocket [chemical binding]; other site 378806010815 heme ligand [chemical binding]; other site 378806010816 YceG-like family; Region: YceG; pfam02618 378806010817 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 378806010818 dimerization interface [polypeptide binding]; other site 378806010819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806010820 PAS fold; Region: PAS_4; pfam08448 378806010821 PAS fold; Region: PAS_4; pfam08448 378806010822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806010823 Heme NO binding associated; Region: HNOBA; pfam07701 378806010824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806010825 dimer interface [polypeptide binding]; other site 378806010826 phosphorylation site [posttranslational modification] 378806010827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806010828 ATP binding site [chemical binding]; other site 378806010829 Mg2+ binding site [ion binding]; other site 378806010830 G-X-G motif; other site 378806010831 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806010832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010833 active site 378806010834 phosphorylation site [posttranslational modification] 378806010835 intermolecular recognition site; other site 378806010836 dimerization interface [polypeptide binding]; other site 378806010837 Response regulator receiver domain; Region: Response_reg; pfam00072 378806010838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010839 active site 378806010840 phosphorylation site [posttranslational modification] 378806010841 intermolecular recognition site; other site 378806010842 dimerization interface [polypeptide binding]; other site 378806010843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806010844 S-adenosylmethionine binding site [chemical binding]; other site 378806010845 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cd00172 378806010846 serpin-like protein; Provisional; Region: PHA02660 378806010847 reactive center loop; other site 378806010848 HYR domain; Region: HYR; pfam02494 378806010849 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806010850 phosphopeptide binding site; other site 378806010851 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806010852 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806010853 active site 378806010854 ATP binding site [chemical binding]; other site 378806010855 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806010856 substrate binding site [chemical binding]; other site 378806010857 activation loop (A-loop); other site 378806010858 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806010859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806010860 Response regulator receiver domain; Region: Response_reg; pfam00072 378806010861 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 378806010862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806010863 non-specific DNA binding site [nucleotide binding]; other site 378806010864 salt bridge; other site 378806010865 sequence-specific DNA binding site [nucleotide binding]; other site 378806010866 Cupin domain; Region: Cupin_2; cl09118 378806010867 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806010868 active site 378806010869 ATP binding site [chemical binding]; other site 378806010870 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806010871 substrate binding site [chemical binding]; other site 378806010872 activation loop (A-loop); other site 378806010873 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 378806010874 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 378806010875 GAF domain; Region: GAF; cl00853 378806010876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806010877 Walker A motif; other site 378806010878 ATP binding site [chemical binding]; other site 378806010879 Walker B motif; other site 378806010880 arginine finger; other site 378806010881 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806010882 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 378806010883 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 378806010884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806010885 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 378806010886 ATP binding site [chemical binding]; other site 378806010887 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 378806010888 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806010889 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 378806010890 putative NAD(P) binding site [chemical binding]; other site 378806010891 active site 378806010892 putative substrate binding site [chemical binding]; other site 378806010893 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 378806010894 putative acyl-acceptor binding pocket; other site 378806010895 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806010896 phosphopeptide binding site; other site 378806010897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806010898 metal binding site [ion binding]; metal-binding site 378806010899 active site 378806010900 I-site; other site 378806010901 Protein of unknown function (DUF721); Region: DUF721; cl02324 378806010902 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 378806010903 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 378806010904 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806010905 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806010906 catalytic residue [active] 378806010907 cytidylate kinase; Provisional; Region: cmk; PRK00023 378806010908 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 378806010909 CMP-binding site; other site 378806010910 The sites determining sugar specificity; other site 378806010911 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 378806010912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806010913 binding surface 378806010914 TPR motif; other site 378806010915 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 378806010916 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 378806010917 DTAP/Switch II; other site 378806010918 Switch I; other site 378806010919 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 378806010920 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806010921 ATP binding site [chemical binding]; other site 378806010922 dimerization interface [polypeptide binding]; other site 378806010923 Metal binding site [ion binding]; metal-binding site 378806010924 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806010925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010926 active site 378806010927 phosphorylation site [posttranslational modification] 378806010928 intermolecular recognition site; other site 378806010929 dimerization interface [polypeptide binding]; other site 378806010930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806010931 Walker A motif; other site 378806010932 ATP binding site [chemical binding]; other site 378806010933 Walker B motif; other site 378806010934 arginine finger; other site 378806010935 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806010936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806010937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806010938 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 378806010939 catalytic motif [active] 378806010940 Zn binding site [ion binding]; other site 378806010941 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 378806010942 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010943 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 378806010944 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 378806010945 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 378806010946 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 378806010947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806010948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806010949 Walker A motif; other site 378806010950 ATP binding site [chemical binding]; other site 378806010951 Walker B motif; other site 378806010952 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378806010953 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 378806010954 active site 378806010955 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 378806010956 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 378806010957 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 378806010958 Ligand Binding Site [chemical binding]; other site 378806010959 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 378806010960 ligand-binding site [chemical binding]; other site 378806010961 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 378806010962 MPN+ (JAMM) motif; other site 378806010963 Zinc-binding site [ion binding]; other site 378806010964 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 378806010965 MoaE interaction surface [polypeptide binding]; other site 378806010966 MoeB interaction surface [polypeptide binding]; other site 378806010967 thiocarboxylated glycine; other site 378806010968 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 378806010969 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 378806010970 ATP binding site [chemical binding]; other site 378806010971 substrate interface [chemical binding]; other site 378806010972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806010973 Histidine kinase; Region: HisKA_3; pfam07730 378806010974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806010975 ATP binding site [chemical binding]; other site 378806010976 Mg2+ binding site [ion binding]; other site 378806010977 G-X-G motif; other site 378806010978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378806010979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806010980 active site 378806010981 phosphorylation site [posttranslational modification] 378806010982 intermolecular recognition site; other site 378806010983 dimerization interface [polypeptide binding]; other site 378806010984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806010985 DNA binding residues [nucleotide binding] 378806010986 dimerization interface [polypeptide binding]; other site 378806010987 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806010988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806010989 DNA-binding site [nucleotide binding]; DNA binding site 378806010990 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 378806010991 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 378806010992 active site 378806010993 phosphorylation site [posttranslational modification] 378806010994 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 378806010995 dimerization domain swap beta strand [polypeptide binding]; other site 378806010996 regulatory protein interface [polypeptide binding]; other site 378806010997 active site 378806010998 regulatory phosphorylation site [posttranslational modification]; other site 378806010999 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 378806011000 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 378806011001 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 378806011002 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 378806011003 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 378806011004 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 378806011005 putative substrate binding site [chemical binding]; other site 378806011006 putative ATP binding site [chemical binding]; other site 378806011007 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 378806011008 P-loop; other site 378806011009 active site 378806011010 phosphorylation site [posttranslational modification] 378806011011 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 378806011012 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 378806011013 P-loop; other site 378806011014 active site 378806011015 phosphorylation site [posttranslational modification] 378806011016 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 378806011017 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 378806011018 amidase catalytic site [active] 378806011019 Zn binding residues [ion binding]; other site 378806011020 substrate binding site [chemical binding]; other site 378806011021 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 378806011022 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 378806011023 acyl-CoA thioesterase II; Provisional; Region: PRK10526 378806011024 active site 378806011025 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 378806011026 catalytic triad [active] 378806011027 dimer interface [polypeptide binding]; other site 378806011028 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 378806011029 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 378806011030 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806011031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806011032 dimer interface [polypeptide binding]; other site 378806011033 phosphorylation site [posttranslational modification] 378806011034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011035 ATP binding site [chemical binding]; other site 378806011036 Mg2+ binding site [ion binding]; other site 378806011037 G-X-G motif; other site 378806011038 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806011039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011040 active site 378806011041 phosphorylation site [posttranslational modification] 378806011042 intermolecular recognition site; other site 378806011043 dimerization interface [polypeptide binding]; other site 378806011044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806011045 Walker A motif; other site 378806011046 ATP binding site [chemical binding]; other site 378806011047 Walker B motif; other site 378806011048 arginine finger; other site 378806011049 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806011050 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011052 active site 378806011053 phosphorylation site [posttranslational modification] 378806011054 intermolecular recognition site; other site 378806011055 dimerization interface [polypeptide binding]; other site 378806011056 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 378806011057 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 378806011058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 378806011059 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 378806011060 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 378806011061 Sulfate transporter family; Region: Sulfate_transp; cl00967 378806011062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806011063 binding surface 378806011064 TPR motif; other site 378806011065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011066 active site 378806011067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806011068 phosphorylation site [posttranslational modification] 378806011069 intermolecular recognition site; other site 378806011070 dimerization interface [polypeptide binding]; other site 378806011071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806011072 dimer interface [polypeptide binding]; other site 378806011073 phosphorylation site [posttranslational modification] 378806011074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011075 ATP binding site [chemical binding]; other site 378806011076 Mg2+ binding site [ion binding]; other site 378806011077 G-X-G motif; other site 378806011078 circadian clock protein KaiC; Reviewed; Region: PRK09302 378806011079 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806011080 Walker A motif; other site 378806011081 ATP binding site [chemical binding]; other site 378806011082 Walker B motif; other site 378806011083 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806011084 Walker A motif; other site 378806011085 ATP binding site [chemical binding]; other site 378806011086 Walker B motif; other site 378806011087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806011088 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806011089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806011090 intermolecular recognition site; other site 378806011091 active site 378806011092 dimerization interface [polypeptide binding]; other site 378806011093 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806011094 G1 box; other site 378806011095 GTP/Mg2+ binding site [chemical binding]; other site 378806011096 G2 box; other site 378806011097 Switch I region; other site 378806011098 G3 box; other site 378806011099 Switch II region; other site 378806011100 G4 box; other site 378806011101 G5 box; other site 378806011102 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 378806011103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806011104 dimer interface [polypeptide binding]; other site 378806011105 phosphorylation site [posttranslational modification] 378806011106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011107 ATP binding site [chemical binding]; other site 378806011108 G-X-G motif; other site 378806011109 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 378806011110 Domain of unknown function DUF20; Region: UPF0118; cl00465 378806011111 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 378806011112 homodimer interface [polypeptide binding]; other site 378806011113 homotetramer interface [polypeptide binding]; other site 378806011114 active site pocket [active] 378806011115 cleavage site 378806011116 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806011117 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 378806011118 Protein export membrane protein; Region: SecD_SecF; cl14618 378806011119 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 378806011120 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378806011121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806011122 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 378806011123 Outer membrane efflux protein; Region: OEP; pfam02321 378806011124 Outer membrane efflux protein; Region: OEP; pfam02321 378806011125 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 378806011126 Surface antigen; Region: Bac_surface_Ag; cl03097 378806011127 Protein kinase domain; Region: Pkinase; pfam00069 378806011128 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806011129 active site 378806011130 ATP binding site [chemical binding]; other site 378806011131 substrate binding site [chemical binding]; other site 378806011132 activation loop (A-loop); other site 378806011133 Predicted ATPase [General function prediction only]; Region: COG3899 378806011134 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806011135 GAF domain; Region: GAF; cl00853 378806011136 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806011137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011138 ATP binding site [chemical binding]; other site 378806011139 Mg2+ binding site [ion binding]; other site 378806011140 G-X-G motif; other site 378806011141 Uncharacterized conserved protein [Function unknown]; Region: COG3349 378806011142 Uncharacterized conserved protein [Function unknown]; Region: COG3349 378806011143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806011144 Uncharacterized conserved protein [Function unknown]; Region: COG3349 378806011145 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 378806011146 Uncharacterized conserved protein [Function unknown]; Region: COG3349 378806011147 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 378806011148 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 378806011149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806011150 active site 378806011151 ATP binding site [chemical binding]; other site 378806011152 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806011153 substrate binding site [chemical binding]; other site 378806011154 activation loop (A-loop); other site 378806011155 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011157 active site 378806011158 phosphorylation site [posttranslational modification] 378806011159 intermolecular recognition site; other site 378806011160 dimerization interface [polypeptide binding]; other site 378806011161 cyclase homology domain; Region: CHD; cd07302 378806011162 nucleotidyl binding site; other site 378806011163 metal binding site [ion binding]; metal-binding site 378806011164 dimer interface [polypeptide binding]; other site 378806011165 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806011166 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 378806011167 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806011168 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 378806011169 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 378806011170 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806011171 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 378806011172 dimer interface [polypeptide binding]; other site 378806011173 active site 378806011174 Schiff base residues; other site 378806011175 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011177 active site 378806011178 phosphorylation site [posttranslational modification] 378806011179 intermolecular recognition site; other site 378806011180 dimerization interface [polypeptide binding]; other site 378806011181 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011183 active site 378806011184 phosphorylation site [posttranslational modification] 378806011185 intermolecular recognition site; other site 378806011186 dimerization interface [polypeptide binding]; other site 378806011187 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378806011188 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 378806011189 Walker A/P-loop; other site 378806011190 ATP binding site [chemical binding]; other site 378806011191 Q-loop/lid; other site 378806011192 ABC transporter signature motif; other site 378806011193 Walker B; other site 378806011194 D-loop; other site 378806011195 H-loop/switch region; other site 378806011196 Flagellin N-methylase; Region: FliB; cl00497 378806011197 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 378806011198 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 378806011199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806011200 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 378806011201 putative dimerization interface [polypeptide binding]; other site 378806011202 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 378806011203 amidase catalytic site [active] 378806011204 Zn binding residues [ion binding]; other site 378806011205 substrate binding site [chemical binding]; other site 378806011206 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 378806011207 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 378806011208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806011209 S-adenosylmethionine binding site [chemical binding]; other site 378806011210 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 378806011211 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 378806011212 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 378806011213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806011214 cell division protein ZipA; Provisional; Region: PRK03427 378806011215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806011216 binding surface 378806011217 TPR motif; other site 378806011218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806011219 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 378806011220 active site 378806011221 phosphorylation site [posttranslational modification] 378806011222 intermolecular recognition site; other site 378806011223 dimerization interface [polypeptide binding]; other site 378806011224 CheB methylesterase; Region: CheB_methylest; pfam01339 378806011225 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 378806011226 putative binding surface; other site 378806011227 active site 378806011228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 378806011229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011230 ATP binding site [chemical binding]; other site 378806011231 Mg2+ binding site [ion binding]; other site 378806011232 G-X-G motif; other site 378806011233 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 378806011234 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806011235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011236 active site 378806011237 phosphorylation site [posttranslational modification] 378806011238 intermolecular recognition site; other site 378806011239 dimerization interface [polypeptide binding]; other site 378806011240 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806011241 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806011242 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806011243 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806011244 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011246 active site 378806011247 phosphorylation site [posttranslational modification] 378806011248 intermolecular recognition site; other site 378806011249 dimerization interface [polypeptide binding]; other site 378806011250 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011252 active site 378806011253 phosphorylation site [posttranslational modification] 378806011254 intermolecular recognition site; other site 378806011255 dimerization interface [polypeptide binding]; other site 378806011256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806011257 FeS/SAM binding site; other site 378806011258 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 378806011259 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 378806011260 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 378806011261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806011262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806011263 DNA binding residues [nucleotide binding] 378806011264 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 378806011265 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 378806011266 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011268 active site 378806011269 phosphorylation site [posttranslational modification] 378806011270 intermolecular recognition site; other site 378806011271 dimerization interface [polypeptide binding]; other site 378806011272 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 378806011273 pantothenate kinase; Provisional; Region: PRK05439 378806011274 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 378806011275 ATP-binding site [chemical binding]; other site 378806011276 CoA-binding site [chemical binding]; other site 378806011277 Mg2+-binding site [ion binding]; other site 378806011278 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 378806011279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806011280 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 378806011281 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 378806011282 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 378806011283 homoserine dehydrogenase; Provisional; Region: PRK06349 378806011284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806011285 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 378806011286 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 378806011287 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806011288 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 378806011289 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 378806011290 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806011291 active site 378806011292 ATP binding site [chemical binding]; other site 378806011293 substrate binding site [chemical binding]; other site 378806011294 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806011295 activation loop (A-loop); other site 378806011296 polycystin cation channel protein; Region: PCC; TIGR00864 378806011297 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 378806011298 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 378806011299 L-ascorbate oxidase, plant type; Region: ascorbase; TIGR03388 378806011300 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 378806011301 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 378806011302 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 378806011303 Cu(I) binding site [ion binding]; other site 378806011304 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 378806011305 Cu(I) binding site [ion binding]; other site 378806011306 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 378806011307 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 378806011308 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 378806011309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806011310 dimer interface [polypeptide binding]; other site 378806011311 phosphorylation site [posttranslational modification] 378806011312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011313 ATP binding site [chemical binding]; other site 378806011314 Mg2+ binding site [ion binding]; other site 378806011315 G-X-G motif; other site 378806011316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011317 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378806011318 active site 378806011319 phosphorylation site [posttranslational modification] 378806011320 intermolecular recognition site; other site 378806011321 dimerization interface [polypeptide binding]; other site 378806011322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806011323 DNA binding site [nucleotide binding] 378806011324 O-methyltransferase; Region: Methyltransf_2; pfam00891 378806011325 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 378806011326 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806011327 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806011328 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 378806011329 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 378806011330 ATP-binding site [chemical binding]; other site 378806011331 Sugar specificity; other site 378806011332 Pyrimidine base specificity; other site 378806011333 Protein of unknown function (DUF692); Region: DUF692; cl01263 378806011334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806011335 S-adenosylmethionine binding site [chemical binding]; other site 378806011336 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 378806011337 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 378806011338 FtsX-like permease family; Region: FtsX; pfam02687 378806011339 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 378806011340 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 378806011341 FtsX-like permease family; Region: FtsX; pfam02687 378806011342 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378806011343 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 378806011344 Walker A/P-loop; other site 378806011345 ATP binding site [chemical binding]; other site 378806011346 Q-loop/lid; other site 378806011347 ABC transporter signature motif; other site 378806011348 Walker B; other site 378806011349 D-loop; other site 378806011350 H-loop/switch region; other site 378806011351 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806011352 Outer membrane efflux protein; Region: OEP; pfam02321 378806011353 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 378806011354 Outer membrane efflux protein; Region: OEP; pfam02321 378806011355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806011356 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 378806011357 Walker A motif; other site 378806011358 ATP binding site [chemical binding]; other site 378806011359 Walker B motif; other site 378806011360 arginine finger; other site 378806011361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806011362 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 378806011363 Walker A motif; other site 378806011364 ATP binding site [chemical binding]; other site 378806011365 Walker B motif; other site 378806011366 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378806011367 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 378806011368 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 378806011369 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 378806011370 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806011371 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806011372 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 378806011373 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806011374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806011375 catalytic residue [active] 378806011376 Protein of unknown function (DUF1279); Region: DUF1279; pfam06916 378806011377 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 378806011378 Predicted peptidase [General function prediction only]; Region: COG4099 378806011379 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806011380 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806011381 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806011382 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806011383 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806011384 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806011385 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806011386 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806011387 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806011388 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806011389 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 378806011390 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 378806011391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806011392 Protein kinase domain; Region: Pkinase; pfam00069 378806011393 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806011394 active site 378806011395 ATP binding site [chemical binding]; other site 378806011396 substrate binding site [chemical binding]; other site 378806011397 activation loop (A-loop); other site 378806011398 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 378806011399 NAD binding site [chemical binding]; other site 378806011400 active site 378806011401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806011402 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 378806011403 putative active site [active] 378806011404 heme pocket [chemical binding]; other site 378806011405 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 378806011406 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806011407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011408 ATP binding site [chemical binding]; other site 378806011409 Mg2+ binding site [ion binding]; other site 378806011410 G-X-G motif; other site 378806011411 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 378806011412 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 378806011413 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 378806011414 active site 378806011415 (T/H)XGH motif; other site 378806011416 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806011417 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 378806011418 cyclase homology domain; Region: CHD; cd07302 378806011419 dimer interface [polypeptide binding]; other site 378806011420 Carbon starvation protein CstA; Region: CstA; cl00856 378806011421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806011422 binding surface 378806011423 TPR motif; other site 378806011424 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 378806011425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806011426 Walker A/P-loop; other site 378806011427 ATP binding site [chemical binding]; other site 378806011428 Q-loop/lid; other site 378806011429 ABC transporter signature motif; other site 378806011430 Walker B; other site 378806011431 D-loop; other site 378806011432 H-loop/switch region; other site 378806011433 Smr domain; Region: Smr; cl02619 378806011434 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 378806011435 putative metal binding site [ion binding]; other site 378806011436 cyclase homology domain; Region: CHD; cd07302 378806011437 nucleotidyl binding site; other site 378806011438 metal binding site [ion binding]; metal-binding site 378806011439 dimer interface [polypeptide binding]; other site 378806011440 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806011441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806011442 binding surface 378806011443 TPR motif; other site 378806011444 ribonuclease R; Region: RNase_R; TIGR02063 378806011445 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 378806011446 RNB domain; Region: RNB; pfam00773 378806011447 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 378806011448 RNA binding site [nucleotide binding]; other site 378806011449 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 378806011450 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 378806011451 dimer interface [polypeptide binding]; other site 378806011452 putative functional site; other site 378806011453 putative MPT binding site; other site 378806011454 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 378806011455 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 378806011456 dimerization interface [polypeptide binding]; other site 378806011457 active site 378806011458 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806011459 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 378806011460 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 378806011461 nudix motif; other site 378806011462 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 378806011463 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 378806011464 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 378806011465 E3 interaction surface; other site 378806011466 lipoyl attachment site [posttranslational modification]; other site 378806011467 e3 binding domain; Region: E3_binding; pfam02817 378806011468 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 378806011469 lipoyl synthase; Provisional; Region: PRK05481 378806011470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806011471 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806011472 active site 378806011473 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 378806011474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806011475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806011476 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 378806011477 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 378806011478 YcaO-like family; Region: YcaO; cl09146 378806011479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806011480 Acyltransferase family; Region: Acyl_transf_3; pfam01757 378806011481 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 378806011482 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 378806011483 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 378806011484 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 378806011485 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 378806011486 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 378806011487 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 378806011488 substrate binding site [chemical binding]; other site 378806011489 glutamase interaction surface [polypeptide binding]; other site 378806011490 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 378806011491 putative active site pocket [active] 378806011492 4-fold oligomerization interface [polypeptide binding]; other site 378806011493 metal binding residues [ion binding]; metal-binding site 378806011494 3-fold/trimer interface [polypeptide binding]; other site 378806011495 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 378806011496 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 378806011497 catalytic residues [active] 378806011498 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 378806011499 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 378806011500 putative active site [active] 378806011501 oxyanion strand; other site 378806011502 catalytic triad [active] 378806011503 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 378806011504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806011505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806011506 homodimer interface [polypeptide binding]; other site 378806011507 catalytic residue [active] 378806011508 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 378806011509 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 378806011510 NAD binding site [chemical binding]; other site 378806011511 dimerization interface [polypeptide binding]; other site 378806011512 product binding site; other site 378806011513 substrate binding site [chemical binding]; other site 378806011514 zinc binding site [ion binding]; other site 378806011515 catalytic residues [active] 378806011516 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 378806011517 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806011518 HisG, C-terminal domain; Region: HisG_C; cl06867 378806011519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011520 active site 378806011521 phosphorylation site [posttranslational modification] 378806011522 intermolecular recognition site; other site 378806011523 dimerization interface [polypeptide binding]; other site 378806011524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 378806011525 Zn2+ binding site [ion binding]; other site 378806011526 Mg2+ binding site [ion binding]; other site 378806011527 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 378806011528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806011529 FeS/SAM binding site; other site 378806011530 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 378806011531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 378806011532 ThiC family; Region: ThiC; cl08031 378806011533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806011534 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806011535 active site 378806011536 ATP binding site [chemical binding]; other site 378806011537 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806011538 substrate binding site [chemical binding]; other site 378806011539 activation loop (A-loop); other site 378806011540 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 378806011541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806011542 S-adenosylmethionine binding site [chemical binding]; other site 378806011543 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 378806011544 classical (c) SDRs; Region: SDR_c; cd05233 378806011545 NAD(P) binding site [chemical binding]; other site 378806011546 active site 378806011547 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 378806011548 putative acyl-acceptor binding pocket; other site 378806011549 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 378806011550 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 378806011551 active site 378806011552 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 378806011553 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 378806011554 nucleophile elbow; other site 378806011555 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806011556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806011557 Walker A motif; other site 378806011558 ATP binding site [chemical binding]; other site 378806011559 Walker B motif; other site 378806011560 arginine finger; other site 378806011561 tetracycline repressor protein TetR; Provisional; Region: PRK13756 378806011562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806011563 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 378806011564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806011565 hypothetical protein; Provisional; Region: PRK06184 378806011566 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806011567 Cupin domain; Region: Cupin_2; cl09118 378806011568 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 378806011569 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 378806011570 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 378806011571 NAD(P) binding site [chemical binding]; other site 378806011572 PilZ domain; Region: PilZ; cl01260 378806011573 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 378806011574 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806011575 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806011576 protein binding site [polypeptide binding]; other site 378806011577 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806011578 protein binding site [polypeptide binding]; other site 378806011579 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 378806011580 dimer interface [polypeptide binding]; other site 378806011581 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 378806011582 FtsH Extracellular; Region: FtsH_ext; pfam06480 378806011583 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 378806011584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806011585 Walker A motif; other site 378806011586 ATP binding site [chemical binding]; other site 378806011587 Walker B motif; other site 378806011588 arginine finger; other site 378806011589 Peptidase family M41; Region: Peptidase_M41; pfam01434 378806011590 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 378806011591 active site 378806011592 8-oxo-dGMP binding site [chemical binding]; other site 378806011593 nudix motif; other site 378806011594 metal binding site [ion binding]; metal-binding site 378806011595 Protein kinase; unclassified specificity; Region: STYKc; smart00221 378806011596 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806011597 active site 378806011598 ATP binding site [chemical binding]; other site 378806011599 substrate binding site [chemical binding]; other site 378806011600 activation loop (A-loop); other site 378806011601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 378806011602 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 378806011603 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 378806011604 putative molybdopterin cofactor binding site [chemical binding]; other site 378806011605 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 378806011606 putative molybdopterin cofactor binding site; other site 378806011607 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 378806011608 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 378806011609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806011610 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 378806011611 putative CheA interaction surface; other site 378806011612 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 378806011613 putative binding surface; other site 378806011614 active site 378806011615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011616 ATP binding site [chemical binding]; other site 378806011617 Mg2+ binding site [ion binding]; other site 378806011618 G-X-G motif; other site 378806011619 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 378806011620 CheD chemotactic sensory transduction; Region: CheD; cl00810 378806011621 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011623 active site 378806011624 phosphorylation site [posttranslational modification] 378806011625 intermolecular recognition site; other site 378806011626 dimerization interface [polypeptide binding]; other site 378806011627 urocanate hydratase; Provisional; Region: PRK05414 378806011628 urocanate hydratase; Region: hutU; TIGR01228 378806011629 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 378806011630 active site 378806011631 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 378806011632 TIGR03442 family protein; Region: TIGR03442 378806011633 putative active site [active] 378806011634 putative dimer interface [polypeptide binding]; other site 378806011635 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 378806011636 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 378806011637 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 378806011638 putative substrate binding site [chemical binding]; other site 378806011639 putative ATP binding site [chemical binding]; other site 378806011640 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 378806011641 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 378806011642 active site 378806011643 hydrophilic channel; other site 378806011644 dimerization interface [polypeptide binding]; other site 378806011645 catalytic residues [active] 378806011646 active site lid [active] 378806011647 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 378806011648 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 378806011649 active site 378806011650 substrate binding site [chemical binding]; other site 378806011651 metal binding site [ion binding]; metal-binding site 378806011652 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 378806011653 dihydropteroate synthase; Region: DHPS; TIGR01496 378806011654 substrate binding pocket [chemical binding]; other site 378806011655 dimer interface [polypeptide binding]; other site 378806011656 inhibitor binding site; inhibition site 378806011657 FtsH Extracellular; Region: FtsH_ext; pfam06480 378806011658 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 378806011659 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806011660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806011661 Walker A motif; other site 378806011662 ATP binding site [chemical binding]; other site 378806011663 Walker B motif; other site 378806011664 arginine finger; other site 378806011665 Peptidase family M41; Region: Peptidase_M41; pfam01434 378806011666 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 378806011667 Ligand Binding Site [chemical binding]; other site 378806011668 B3/4 domain; Region: B3_4; cl11458 378806011669 Protein of unknown function, DUF399; Region: DUF399; cl01139 378806011670 Protein of unknown function (DUF419); Region: DUF419; cl09948 378806011671 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 378806011672 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 378806011673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806011674 S-adenosylmethionine binding site [chemical binding]; other site 378806011675 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806011676 classical (c) SDRs; Region: SDR_c; cd05233 378806011677 NAD(P) binding site [chemical binding]; other site 378806011678 active site 378806011679 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 378806011680 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 378806011681 active site 2 [active] 378806011682 active site 1 [active] 378806011683 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine...; Region: B12-binding; cd02067 378806011684 B12 binding site [chemical binding]; other site 378806011685 cobalt ligand [ion binding]; other site 378806011686 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 378806011687 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 378806011688 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 378806011689 tetramer interface [polypeptide binding]; other site 378806011690 heme binding pocket [chemical binding]; other site 378806011691 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 378806011692 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 378806011693 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 378806011694 NAD(P) binding site [chemical binding]; other site 378806011695 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806011696 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 378806011697 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 378806011698 Flavoprotein; Region: Flavoprotein; cl08021 378806011699 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 378806011700 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 378806011701 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 378806011702 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 378806011703 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 378806011704 FAD binding pocket [chemical binding]; other site 378806011705 FAD binding motif [chemical binding]; other site 378806011706 phosphate binding motif [ion binding]; other site 378806011707 NAD binding pocket [chemical binding]; other site 378806011708 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 378806011709 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 378806011710 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806011711 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 378806011712 putative ligand binding site [chemical binding]; other site 378806011713 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 378806011714 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 378806011715 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806011716 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806011717 catalytic residue [active] 378806011718 Protein phosphatase 2C; Region: PP2C; pfam00481 378806011719 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 378806011720 Active site [active] 378806011721 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806011722 ligand binding site [chemical binding]; other site 378806011723 flexible hinge region; other site 378806011724 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 378806011725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806011726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806011727 dimer interface [polypeptide binding]; other site 378806011728 phosphorylation site [posttranslational modification] 378806011729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011730 ATP binding site [chemical binding]; other site 378806011731 Mg2+ binding site [ion binding]; other site 378806011732 G-X-G motif; other site 378806011733 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 378806011734 Sulfatase; Region: Sulfatase; cl10460 378806011735 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 378806011736 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 378806011737 Interdomain contacts; other site 378806011738 Cytokine receptor motif; other site 378806011739 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 378806011740 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 378806011741 active site 378806011742 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 378806011743 catalytic residue [active] 378806011744 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378806011745 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378806011746 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 378806011747 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 378806011748 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 378806011749 Domain of unknown function (DUF329); Region: DUF329; cl01144 378806011750 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 378806011751 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 378806011752 NAD(P) binding site [chemical binding]; other site 378806011753 Arginase family; Region: Arginase; cl00306 378806011754 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011756 active site 378806011757 phosphorylation site [posttranslational modification] 378806011758 intermolecular recognition site; other site 378806011759 dimerization interface [polypeptide binding]; other site 378806011760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806011761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011762 ATP binding site [chemical binding]; other site 378806011763 Mg2+ binding site [ion binding]; other site 378806011764 G-X-G motif; other site 378806011765 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 378806011766 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806011767 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806011768 protein binding site [polypeptide binding]; other site 378806011769 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806011770 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806011771 active site 378806011772 ATP binding site [chemical binding]; other site 378806011773 substrate binding site [chemical binding]; other site 378806011774 activation loop (A-loop); other site 378806011775 PEGA domain; Region: PEGA; pfam08308 378806011776 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806011777 active site 378806011778 ATP binding site [chemical binding]; other site 378806011779 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806011780 substrate binding site [chemical binding]; other site 378806011781 activation loop (A-loop); other site 378806011782 GAF domain; Region: GAF; cl00853 378806011783 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806011784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806011785 Walker A motif; other site 378806011786 ATP binding site [chemical binding]; other site 378806011787 Walker B motif; other site 378806011788 arginine finger; other site 378806011789 hypothetical protein; Provisional; Region: PRK11770 378806011790 Domain of unknown function (DUF307); Region: DUF307; pfam03733 378806011791 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806011792 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 378806011793 active site 378806011794 metal binding site [ion binding]; metal-binding site 378806011795 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011797 active site 378806011798 phosphorylation site [posttranslational modification] 378806011799 intermolecular recognition site; other site 378806011800 dimerization interface [polypeptide binding]; other site 378806011801 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 378806011802 FecR protein; Region: FecR; pfam04773 378806011803 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806011804 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806011805 dimerization interface [polypeptide binding]; other site 378806011806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806011807 phosphorylation site [posttranslational modification] 378806011808 dimer interface [polypeptide binding]; other site 378806011809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011810 ATP binding site [chemical binding]; other site 378806011811 Mg2+ binding site [ion binding]; other site 378806011812 G-X-G motif; other site 378806011813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011814 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011815 active site 378806011816 phosphorylation site [posttranslational modification] 378806011817 intermolecular recognition site; other site 378806011818 dimerization interface [polypeptide binding]; other site 378806011819 GAF domain; Region: GAF; cl00853 378806011820 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806011821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806011822 dimer interface [polypeptide binding]; other site 378806011823 phosphorylation site [posttranslational modification] 378806011824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011825 ATP binding site [chemical binding]; other site 378806011826 Mg2+ binding site [ion binding]; other site 378806011827 G-X-G motif; other site 378806011828 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011830 active site 378806011831 phosphorylation site [posttranslational modification] 378806011832 intermolecular recognition site; other site 378806011833 dimerization interface [polypeptide binding]; other site 378806011834 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011836 active site 378806011837 phosphorylation site [posttranslational modification] 378806011838 intermolecular recognition site; other site 378806011839 dimerization interface [polypeptide binding]; other site 378806011840 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806011841 metal binding site [ion binding]; metal-binding site 378806011842 active site 378806011843 I-site; other site 378806011844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806011845 LexA repressor; Validated; Region: PRK00215 378806011846 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 378806011847 Catalytic site [active] 378806011848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806011849 binding surface 378806011850 TPR motif; other site 378806011851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806011852 binding surface 378806011853 TPR motif; other site 378806011854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806011855 binding surface 378806011856 TPR motif; other site 378806011857 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806011858 putative peptidoglycan binding site; other site 378806011859 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806011860 Survival protein SurE; Region: SurE; cl00448 378806011861 enolase; Provisional; Region: eno; PRK00077 378806011862 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 378806011863 dimer interface [polypeptide binding]; other site 378806011864 metal binding site [ion binding]; metal-binding site 378806011865 substrate binding pocket [chemical binding]; other site 378806011866 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 378806011867 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 378806011868 hydrophobic ligand binding site; other site 378806011869 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 378806011870 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 378806011871 putative active site [active] 378806011872 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 378806011873 active site 378806011874 Sulfatase; Region: Sulfatase; cl10460 378806011875 Sulfatase; Region: Sulfatase; cl10460 378806011876 Sulfatase; Region: Sulfatase; cl10460 378806011877 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 378806011878 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 378806011879 dimerization interface [polypeptide binding]; other site 378806011880 active site 378806011881 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 378806011882 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806011883 active site 378806011884 HIGH motif; other site 378806011885 nucleotide binding site [chemical binding]; other site 378806011886 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 378806011887 active site 378806011888 KMSKS motif; other site 378806011889 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 378806011890 tRNA binding surface [nucleotide binding]; other site 378806011891 anticodon binding site; other site 378806011892 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 378806011893 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011895 active site 378806011896 phosphorylation site [posttranslational modification] 378806011897 intermolecular recognition site; other site 378806011898 dimerization interface [polypeptide binding]; other site 378806011899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011900 active site 378806011901 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 378806011902 phosphorylation site [posttranslational modification] 378806011903 intermolecular recognition site; other site 378806011904 dimerization interface [polypeptide binding]; other site 378806011905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806011906 metal binding site [ion binding]; metal-binding site 378806011907 active site 378806011908 I-site; other site 378806011909 Uncharacterized conserved protein [Function unknown]; Region: COG3461 378806011910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806011911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806011912 ATP binding site [chemical binding]; other site 378806011913 G-X-G motif; other site 378806011914 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011916 active site 378806011917 phosphorylation site [posttranslational modification] 378806011918 intermolecular recognition site; other site 378806011919 dimerization interface [polypeptide binding]; other site 378806011920 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806011921 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 378806011922 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 378806011923 ring oligomerisation interface [polypeptide binding]; other site 378806011924 ATP/Mg binding site [chemical binding]; other site 378806011925 stacking interactions; other site 378806011926 hinge regions; other site 378806011927 Response regulator receiver domain; Region: Response_reg; pfam00072 378806011928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806011929 active site 378806011930 phosphorylation site [posttranslational modification] 378806011931 intermolecular recognition site; other site 378806011932 dimerization interface [polypeptide binding]; other site 378806011933 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806011934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806011935 binding surface 378806011936 TPR motif; other site 378806011937 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 378806011938 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806011939 active site 378806011940 ATP binding site [chemical binding]; other site 378806011941 substrate binding site [chemical binding]; other site 378806011942 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806011943 activation loop (A-loop); other site 378806011944 activation loop (A-loop); other site 378806011945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806011946 non-specific DNA binding site [nucleotide binding]; other site 378806011947 salt bridge; other site 378806011948 sequence-specific DNA binding site [nucleotide binding]; other site 378806011949 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806011950 Thioesterase domain; Region: Thioesterase; pfam00975 378806011951 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806011952 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806011953 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806011954 active site 378806011955 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806011956 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806011957 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806011958 active site 378806011959 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806011960 PKS_DH; Region: PKS_DH; smart00826 378806011961 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806011962 putative NADP binding site [chemical binding]; other site 378806011963 active site 378806011964 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806011965 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 378806011966 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 378806011967 B12 binding site [chemical binding]; other site 378806011968 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806011969 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 378806011970 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806011971 putative NADP binding site [chemical binding]; other site 378806011972 active site 378806011973 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806011974 arsenite-activated ATPase ArsA; Region: arsA; TIGR00345 378806011975 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806011976 dimerization interface [polypeptide binding]; other site 378806011977 Metal binding site [ion binding]; metal-binding site 378806011978 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 378806011979 active site 378806011980 nucleophile elbow; other site 378806011981 Condensation domain; Region: Condensation; cl09290 378806011982 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806011983 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806011984 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806011985 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806011986 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 378806011987 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806011988 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806011989 active site 378806011990 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806011991 PKS_DH; Region: PKS_DH; smart00826 378806011992 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806011993 putative NADP binding site [chemical binding]; other site 378806011994 active site 378806011995 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806011996 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806011997 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806011998 active site 378806011999 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806012000 PKS_DH; Region: PKS_DH; smart00826 378806012001 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806012002 putative NADP binding site [chemical binding]; other site 378806012003 active site 378806012004 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012005 Condensation domain; Region: Condensation; cl09290 378806012006 Nonribosomal peptide synthase; Region: NRPS; pfam08415 378806012007 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806012008 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012009 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012010 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806012011 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806012012 active site 378806012013 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806012014 PKS_DH; Region: PKS_DH; smart00826 378806012015 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806012016 putative NADP binding site [chemical binding]; other site 378806012017 active site 378806012018 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012019 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806012020 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806012021 active site 378806012022 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806012023 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806012024 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806012025 putative NADP binding site [chemical binding]; other site 378806012026 active site 378806012027 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012028 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806012029 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806012030 active site 378806012031 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806012033 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806012034 active site 378806012035 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012036 AMP-binding enzyme; Region: AMP-binding; pfam00501 378806012037 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012038 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806012040 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806012041 MbtH-like protein; Region: MbtH; cl01279 378806012042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806012043 Condensation domain; Region: Condensation; cl09290 378806012044 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012045 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806012046 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012047 Condensation domain; Region: Condensation; cl09290 378806012048 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806012049 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012050 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012051 Condensation domain; Region: Condensation; cl09290 378806012052 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806012053 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012054 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012055 acyl-CoA synthetase; Validated; Region: PRK05850 378806012056 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012057 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012058 Condensation domain; Region: Condensation; cl09290 378806012059 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012060 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806012061 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012062 Condensation domain; Region: Condensation; cl09290 378806012063 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806012064 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012065 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012066 Condensation domain; Region: Condensation; cl09290 378806012067 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806012068 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012069 peptide synthase; Provisional; Region: PRK12467 378806012070 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012071 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 378806012072 metal binding site [ion binding]; metal-binding site 378806012073 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378806012074 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 378806012075 Walker A/P-loop; other site 378806012076 ATP binding site [chemical binding]; other site 378806012077 Q-loop/lid; other site 378806012078 ABC transporter signature motif; other site 378806012079 Walker B; other site 378806012080 D-loop; other site 378806012081 H-loop/switch region; other site 378806012082 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806012083 argininosuccinate lyase; Provisional; Region: PRK02186 378806012084 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806012085 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 378806012086 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 378806012087 dimer interface [polypeptide binding]; other site 378806012088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806012089 catalytic residue [active] 378806012090 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 378806012091 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 378806012092 active sites [active] 378806012093 tetramer interface [polypeptide binding]; other site 378806012094 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 378806012095 putative deacylase active site [active] 378806012096 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 378806012097 helicase 45; Provisional; Region: PTZ00424 378806012098 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 378806012099 ATP binding site [chemical binding]; other site 378806012100 Mg++ binding site [ion binding]; other site 378806012101 motif III; other site 378806012102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806012103 nucleotide binding region [chemical binding]; other site 378806012104 ATP-binding site [chemical binding]; other site 378806012105 DbpA RNA binding domain; Region: DbpA; pfam03880 378806012106 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 378806012107 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 378806012108 catalytic core [active] 378806012109 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806012110 ligand binding site [chemical binding]; other site 378806012111 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806012112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806012113 active site 378806012114 phosphorylation site [posttranslational modification] 378806012115 intermolecular recognition site; other site 378806012116 dimerization interface [polypeptide binding]; other site 378806012117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806012118 Walker A motif; other site 378806012119 ATP binding site [chemical binding]; other site 378806012120 Walker B motif; other site 378806012121 arginine finger; other site 378806012122 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806012123 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806012124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806012125 dimer interface [polypeptide binding]; other site 378806012126 phosphorylation site [posttranslational modification] 378806012127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806012128 ATP binding site [chemical binding]; other site 378806012129 G-X-G motif; other site 378806012130 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 378806012131 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 378806012132 B12 binding site [chemical binding]; other site 378806012133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806012134 FeS/SAM binding site; other site 378806012135 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 378806012136 dinuclear metal binding motif [ion binding]; other site 378806012137 cyclase homology domain; Region: CHD; cd07302 378806012138 nucleotidyl binding site; other site 378806012139 metal binding site [ion binding]; metal-binding site 378806012140 dimer interface [polypeptide binding]; other site 378806012141 cyclase homology domain; Region: CHD; cd07302 378806012142 nucleotidyl binding site; other site 378806012143 dimer interface [polypeptide binding]; other site 378806012144 metal binding site [ion binding]; metal-binding site 378806012145 Predicted ATPase [General function prediction only]; Region: COG3899 378806012146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806012147 binding surface 378806012148 TPR motif; other site 378806012149 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 378806012150 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 378806012151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806012152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806012153 homodimer interface [polypeptide binding]; other site 378806012154 catalytic residue [active] 378806012155 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 378806012156 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 378806012157 alpha subunit interface [polypeptide binding]; other site 378806012158 TPP binding site [chemical binding]; other site 378806012159 heterodimer interface [polypeptide binding]; other site 378806012160 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 378806012161 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 378806012162 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 378806012163 TPP-binding site [chemical binding]; other site 378806012164 tetramer interface [polypeptide binding]; other site 378806012165 heterodimer interface [polypeptide binding]; other site 378806012166 phosphorylation loop region [posttranslational modification] 378806012167 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 378806012168 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 378806012169 substrate binding site [chemical binding]; other site 378806012170 ligand binding site [chemical binding]; other site 378806012171 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 378806012172 substrate binding site [chemical binding]; other site 378806012173 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 378806012174 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 378806012175 active site 378806012176 catalytic residues [active] 378806012177 metal binding site [ion binding]; metal-binding site 378806012178 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 378806012179 isocitrate dehydrogenase; Validated; Region: PRK06451 378806012180 O-methyltransferase; Region: Methyltransf_2; pfam00891 378806012181 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 378806012182 active site 378806012183 metal binding site [ion binding]; metal-binding site 378806012184 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 378806012185 Cytochrome c; Region: Cytochrom_C; cl11414 378806012186 Protein kinase domain; Region: Pkinase; pfam00069 378806012187 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806012188 active site 378806012189 ATP binding site [chemical binding]; other site 378806012190 substrate binding site [chemical binding]; other site 378806012191 activation loop (A-loop); other site 378806012192 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 378806012193 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806012194 N-terminal plug; other site 378806012195 ligand-binding site [chemical binding]; other site 378806012196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806012197 substrate binding pocket [chemical binding]; other site 378806012198 membrane-bound complex binding site; other site 378806012199 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806012200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806012201 TPR motif; other site 378806012202 binding surface 378806012203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806012204 binding surface 378806012205 TPR motif; other site 378806012206 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806012207 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 378806012208 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 378806012209 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 378806012210 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 378806012211 tetramer interface [polypeptide binding]; other site 378806012212 TPP-binding site [chemical binding]; other site 378806012213 heterodimer interface [polypeptide binding]; other site 378806012214 phosphorylation loop region [posttranslational modification] 378806012215 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 378806012216 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 378806012217 PYR/PP interface [polypeptide binding]; other site 378806012218 dimer interface [polypeptide binding]; other site 378806012219 TPP binding site [chemical binding]; other site 378806012220 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 378806012221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806012222 Coenzyme A binding pocket [chemical binding]; other site 378806012223 PilZ domain; Region: PilZ; cl01260 378806012224 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 378806012225 active site 378806012226 catalytic triad [active] 378806012227 oxyanion hole [active] 378806012228 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 378806012229 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 378806012230 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 378806012231 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 378806012232 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 378806012233 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 378806012234 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806012235 active site 378806012236 metal binding site [ion binding]; metal-binding site 378806012237 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 378806012238 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 378806012239 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 378806012240 active site 378806012241 Zn binding site [ion binding]; other site 378806012242 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806012243 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806012244 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 378806012245 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 378806012246 minor groove reading motif; other site 378806012247 helix-hairpin-helix signature motif; other site 378806012248 substrate binding pocket [chemical binding]; other site 378806012249 active site 378806012250 FES domain; Region: FES; smart00525 378806012251 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 378806012252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806012253 Walker A/P-loop; other site 378806012254 ATP binding site [chemical binding]; other site 378806012255 Q-loop/lid; other site 378806012256 ABC transporter signature motif; other site 378806012257 Walker B; other site 378806012258 D-loop; other site 378806012259 H-loop/switch region; other site 378806012260 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 378806012261 TM-ABC transporter signature motif; other site 378806012262 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 378806012263 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 378806012264 putative ligand binding site [chemical binding]; other site 378806012265 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 378806012266 substrate binding site [chemical binding]; other site 378806012267 ATP binding site [chemical binding]; other site 378806012268 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 378806012269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806012270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806012271 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 378806012272 Peptidase family U32; Region: Peptidase_U32; cl03113 378806012273 Collagenase; Region: DUF3656; pfam12392 378806012274 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806012275 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806012276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806012277 dimer interface [polypeptide binding]; other site 378806012278 phosphorylation site [posttranslational modification] 378806012279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806012280 ATP binding site [chemical binding]; other site 378806012281 Mg2+ binding site [ion binding]; other site 378806012282 G-X-G motif; other site 378806012283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806012284 dimer interface [polypeptide binding]; other site 378806012285 phosphorylation site [posttranslational modification] 378806012286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806012287 ATP binding site [chemical binding]; other site 378806012288 G-X-G motif; other site 378806012289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378806012290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806012291 active site 378806012292 phosphorylation site [posttranslational modification] 378806012293 intermolecular recognition site; other site 378806012294 dimerization interface [polypeptide binding]; other site 378806012295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806012296 DNA binding site [nucleotide binding] 378806012297 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806012298 Beta-lactamase; Region: Beta-lactamase; cl01009 378806012299 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 378806012300 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806012301 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806012302 active site 378806012303 ATP binding site [chemical binding]; other site 378806012304 substrate binding site [chemical binding]; other site 378806012305 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806012306 activation loop (A-loop); other site 378806012307 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806012308 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 378806012309 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806012310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806012311 DNA-binding site [nucleotide binding]; DNA binding site 378806012312 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 378806012313 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 378806012314 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 378806012315 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 378806012316 putative hydrophobic ligand binding site [chemical binding]; other site 378806012317 protein interface [polypeptide binding]; other site 378806012318 gate; other site 378806012319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806012320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806012321 NAD(P) binding site [chemical binding]; other site 378806012322 active site 378806012323 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378806012324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806012325 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 378806012326 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 378806012327 G1 box; other site 378806012328 GTP/Mg2+ binding site [chemical binding]; other site 378806012329 Switch I region; other site 378806012330 G2 box; other site 378806012331 G3 box; other site 378806012332 Switch II region; other site 378806012333 G4 box; other site 378806012334 G5 box; other site 378806012335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806012336 Uncharacterized conserved protein [Function unknown]; Region: COG3349 378806012337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806012338 Beta-lactamase; Region: Beta-lactamase; cl01009 378806012339 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 378806012340 Condensation domain; Region: Condensation; cl09290 378806012341 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 378806012342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806012343 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806012344 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa...; Region: ACD_sHsps_p23-like; cd00298 378806012345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806012346 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 378806012347 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 378806012348 ligand binding site [chemical binding]; other site 378806012349 oligomer interface [polypeptide binding]; other site 378806012350 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 378806012351 dimer interface [polypeptide binding]; other site 378806012352 N-terminal domain interface [polypeptide binding]; other site 378806012353 sulfate 1 binding site; other site 378806012354 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 378806012355 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 378806012356 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378806012357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806012358 active site 378806012359 phosphorylation site [posttranslational modification] 378806012360 intermolecular recognition site; other site 378806012361 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806012362 DNA binding residues [nucleotide binding] 378806012363 dimerization interface [polypeptide binding]; other site 378806012364 RDD family; Region: RDD; cl00746 378806012365 Integral membrane protein DUF95; Region: DUF95; cl00572 378806012366 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 378806012367 HSP70 interaction site [polypeptide binding]; other site 378806012368 Vesicle coat complex, various subunits [Intracellular trafficking and secretion]; Region: COG5096 378806012369 Beta-propeller repeat; Region: SBBP; pfam06739 378806012370 von Willebrand factor type D domain; Region: VWD; cl02516 378806012371 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806012372 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806012373 calcium binding site 2 [ion binding]; other site 378806012374 active site 378806012375 catalytic triad [active] 378806012376 calcium binding site 1 [ion binding]; other site 378806012377 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806012378 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806012379 Lipoprotein N-terminal Domain; Region: LPD_N; smart00638 378806012380 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 378806012381 thioester formation/cholesterol transfer; other site 378806012382 protein-splicing catalytic site; other site 378806012383 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 378806012384 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 378806012385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806012386 DivIVA protein; Region: DivIVA; pfam05103 378806012387 DivIVA domain; Region: DivI1A_domain; TIGR03544 378806012388 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 378806012389 Protein of unknown function (DUF1570); Region: DUF1570; pfam07607 378806012390 DNA polymerase I; Provisional; Region: PRK05755 378806012391 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 378806012392 active site 378806012393 metal binding site 1 [ion binding]; metal-binding site 378806012394 putative 5' ssDNA interaction site; other site 378806012395 metal binding site 3; metal-binding site 378806012396 metal binding site 2 [ion binding]; metal-binding site 378806012397 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 378806012398 putative DNA binding site [nucleotide binding]; other site 378806012399 putative metal binding site [ion binding]; other site 378806012400 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 378806012401 active site 378806012402 catalytic site [active] 378806012403 substrate binding site [chemical binding]; other site 378806012404 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 378806012405 active site 378806012406 DNA binding site [nucleotide binding] 378806012407 catalytic site [active] 378806012408 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 378806012409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806012410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 378806012411 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806012412 active site 378806012413 ATP binding site [chemical binding]; other site 378806012414 substrate binding site [chemical binding]; other site 378806012415 activation loop (A-loop); other site 378806012416 DNA helicase, putative; Region: TIGR00376 378806012417 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 378806012418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806012419 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 378806012420 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 378806012421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806012422 Walker A motif; other site 378806012423 ATP binding site [chemical binding]; other site 378806012424 Walker B motif; other site 378806012425 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 378806012426 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 378806012427 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 378806012428 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 378806012429 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 378806012430 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806012431 phosphopeptide binding site; other site 378806012432 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806012433 phosphopeptide binding site; other site 378806012434 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806012435 phosphopeptide binding site; other site 378806012436 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 378806012437 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 378806012438 ATP binding site [chemical binding]; other site 378806012439 Walker A motif; other site 378806012440 hexamer interface [polypeptide binding]; other site 378806012441 Walker B motif; other site 378806012442 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 378806012443 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 378806012444 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 378806012445 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 378806012446 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806012447 phosphopeptide binding site; other site 378806012448 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 378806012449 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 378806012450 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 378806012451 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 378806012452 dimer interface [polypeptide binding]; other site 378806012453 motif 1; other site 378806012454 active site 378806012455 motif 2; other site 378806012456 motif 3; other site 378806012457 Protein kinase domain; Region: Pkinase; pfam00069 378806012458 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806012459 active site 378806012460 ATP binding site [chemical binding]; other site 378806012461 substrate binding site [chemical binding]; other site 378806012462 activation loop (A-loop); other site 378806012463 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806012464 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 378806012465 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806012467 active site 378806012468 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806012469 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012470 acyl-CoA synthetase; Validated; Region: PRK05850 378806012471 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012472 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012473 Condensation domain; Region: Condensation; cl09290 378806012474 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 378806012475 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012476 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012477 Condensation domain; Region: Condensation; cl09290 378806012478 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 378806012479 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806012480 Condensation domain; Region: Condensation; cl09290 378806012481 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 378806012482 Beta-lactamase; Region: Beta-lactamase; cl01009 378806012483 SCP-2 sterol transfer family; Region: SCP2; cl01225 378806012484 JmjC domain; Region: JmjC; pfam02373 378806012485 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806012486 classical (c) SDRs; Region: SDR_c; cd05233 378806012487 NAD(P) binding site [chemical binding]; other site 378806012488 active site 378806012489 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 378806012490 Cupin domain; Region: Cupin_2; cl09118 378806012491 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806012492 DNA binding residues [nucleotide binding] 378806012493 dimerization interface [polypeptide binding]; other site 378806012494 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 378806012495 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 378806012496 metal ion-dependent adhesion site (MIDAS); other site 378806012497 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 378806012498 Recombination protein O N terminal; Region: RecO_N; pfam11967 378806012499 Recombination protein O C terminal; Region: RecO_C; pfam02565 378806012500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 378806012501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 378806012502 binding surface 378806012503 TPR motif; other site 378806012504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806012505 binding surface 378806012506 TPR motif; other site 378806012507 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806012508 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806012509 catalytic residue [active] 378806012510 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 378806012511 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 378806012512 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 378806012513 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 378806012514 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 378806012515 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 378806012516 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 378806012517 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 378806012518 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 378806012519 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 378806012520 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 378806012521 DNA binding site [nucleotide binding] 378806012522 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 378806012523 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 378806012524 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 378806012525 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 378806012526 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 378806012527 RPB12 interaction site [polypeptide binding]; other site 378806012528 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 378806012529 RPB11 interaction site [polypeptide binding]; other site 378806012530 RPB12 interaction site [polypeptide binding]; other site 378806012531 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 378806012532 RPB3 interaction site [polypeptide binding]; other site 378806012533 RPB1 interaction site [polypeptide binding]; other site 378806012534 RPB11 interaction site [polypeptide binding]; other site 378806012535 RPB10 interaction site [polypeptide binding]; other site 378806012536 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 378806012537 core dimer interface [polypeptide binding]; other site 378806012538 peripheral dimer interface [polypeptide binding]; other site 378806012539 L10 interface [polypeptide binding]; other site 378806012540 L11 interface [polypeptide binding]; other site 378806012541 putative EF-Tu interaction site [polypeptide binding]; other site 378806012542 putative EF-G interaction site [polypeptide binding]; other site 378806012543 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 378806012544 23S rRNA interface [nucleotide binding]; other site 378806012545 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 378806012546 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 378806012547 mRNA/rRNA interface [nucleotide binding]; other site 378806012548 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 378806012549 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 378806012550 23S rRNA interface [nucleotide binding]; other site 378806012551 L7/L12 interface [polypeptide binding]; other site 378806012552 putative thiostrepton binding site; other site 378806012553 L25 interface [polypeptide binding]; other site 378806012554 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 378806012555 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 378806012556 putative homodimer interface [polypeptide binding]; other site 378806012557 KOW motif; Region: KOW; cl00354 378806012558 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 378806012559 elongation factor Tu; Reviewed; Region: PRK00049 378806012560 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 378806012561 G1 box; other site 378806012562 GEF interaction site [polypeptide binding]; other site 378806012563 GTP/Mg2+ binding site [chemical binding]; other site 378806012564 Switch I region; other site 378806012565 G2 box; other site 378806012566 G3 box; other site 378806012567 Switch II region; other site 378806012568 G4 box; other site 378806012569 G5 box; other site 378806012570 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 378806012571 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 378806012572 Antibiotic Binding Site [chemical binding]; other site 378806012573 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 378806012574 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 378806012575 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 378806012576 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 378806012577 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 378806012578 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806012579 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806012580 metal ion-dependent adhesion site (MIDAS); other site 378806012581 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806012582 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 378806012583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806012584 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 378806012585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806012586 ATP binding site [chemical binding]; other site 378806012587 putative Mg++ binding site [ion binding]; other site 378806012588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806012589 Helicase associated domain (HA2); Region: HA2; cl04503 378806012590 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 378806012591 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 378806012592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806012593 MFS_1 like family; Region: MFS_1_like; pfam12832 378806012594 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378806012595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806012596 Ferredoxin [Energy production and conversion]; Region: COG1146 378806012597 4Fe-4S binding domain; Region: Fer4; cl02805 378806012598 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 378806012599 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 378806012600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806012601 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 378806012602 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 378806012603 active site residue [active] 378806012604 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 378806012605 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 378806012606 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 378806012607 Stage II sporulation protein; Region: SpoIID; cl07201 378806012608 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806012609 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 378806012610 Cation efflux family; Region: Cation_efflux; cl00316 378806012611 glycine dehydrogenase; Provisional; Region: PRK05367 378806012612 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 378806012613 tetramer interface [polypeptide binding]; other site 378806012614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806012615 catalytic residue [active] 378806012616 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 378806012617 tetramer interface [polypeptide binding]; other site 378806012618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806012619 catalytic residue [active] 378806012620 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 378806012621 lipoyl attachment site [posttranslational modification]; other site 378806012622 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 378806012623 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 378806012624 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 378806012625 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 378806012626 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 378806012627 FAD binding site [chemical binding]; other site 378806012628 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 378806012629 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 378806012630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 378806012631 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 378806012632 homodimer interface [polypeptide binding]; other site 378806012633 NADP binding site [chemical binding]; other site 378806012634 substrate binding site [chemical binding]; other site 378806012635 Protein of unknown function (DUF456); Region: DUF456; cl01069 378806012636 tellurium resistance terB-like protein; Region: terB_like; cl11965 378806012637 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 378806012638 HSP70 interaction site [polypeptide binding]; other site 378806012639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 378806012640 Smr domain; Region: Smr; cl02619 378806012641 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806012642 active site 378806012643 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 378806012644 quinone interaction residues [chemical binding]; other site 378806012645 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 378806012646 active site 378806012647 catalytic residues [active] 378806012648 FMN binding site [chemical binding]; other site 378806012649 substrate binding site [chemical binding]; other site 378806012650 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 378806012651 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 378806012652 putative ADP-binding pocket [chemical binding]; other site 378806012653 O-Antigen ligase; Region: Wzy_C; cl04850 378806012654 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 378806012655 G1 box; other site 378806012656 GTP/Mg2+ binding site [chemical binding]; other site 378806012657 Switch I region; other site 378806012658 G2 box; other site 378806012659 G3 box; other site 378806012660 Switch II region; other site 378806012661 G4 box; other site 378806012662 G5 box; other site 378806012663 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 378806012664 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 378806012665 CoA-binding site [chemical binding]; other site 378806012666 thioester reductase domain; Region: Thioester-redct; TIGR01746 378806012667 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 378806012668 putative NAD(P) binding site [chemical binding]; other site 378806012669 active site 378806012670 putative substrate binding site [chemical binding]; other site 378806012671 REJ domain; Region: REJ; pfam02010 378806012672 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 378806012673 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_subtilisin_1; cd04818 378806012674 PA/protease or protease-like domain interface [polypeptide binding]; other site 378806012675 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 378806012676 Zn binding site [ion binding]; other site 378806012677 REJ domain; Region: REJ; pfam02010 378806012678 REJ domain; Region: REJ; pfam02010 378806012679 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 378806012680 active site 2 [active] 378806012681 active site 1 [active] 378806012682 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 378806012683 active site 378806012684 catalytic site [active] 378806012685 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806012686 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 378806012687 active site 378806012688 catalytic tetrad [active] 378806012689 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806012690 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 378806012691 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20...; Region: CBM20; cl08281 378806012692 Putative esterase; Region: Esterase; pfam00756 378806012693 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806012694 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 378806012695 HSP70 interaction site [polypeptide binding]; other site 378806012696 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 378806012697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806012698 binding surface 378806012699 TPR motif; other site 378806012700 acetylornithine aminotransferase; Provisional; Region: PRK02627 378806012701 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806012702 inhibitor-cofactor binding pocket; inhibition site 378806012703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806012704 catalytic residue [active] 378806012705 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 378806012706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806012707 Walker A motif; other site 378806012708 ATP binding site [chemical binding]; other site 378806012709 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806012710 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 378806012711 active site 378806012712 HslU subunit interaction site [polypeptide binding]; other site 378806012713 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-...; Region: SCP_PR-1_like; cd05381 378806012714 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 378806012715 Protein kinase domain; Region: Pkinase; pfam00069 378806012716 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806012717 active site 378806012718 ATP binding site [chemical binding]; other site 378806012719 substrate binding site [chemical binding]; other site 378806012720 activation loop (A-loop); other site 378806012721 Protein kinase domain; Region: Pkinase; pfam00069 378806012722 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806012723 active site 378806012724 ATP binding site [chemical binding]; other site 378806012725 substrate binding site [chemical binding]; other site 378806012726 activation loop (A-loop); other site 378806012727 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 378806012728 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 378806012729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806012730 DNA binding residues [nucleotide binding] 378806012731 Beta-propeller repeat; Region: SBBP; pfam06739 378806012732 Beta-propeller repeat; Region: SBBP; pfam06739 378806012733 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 378806012734 Protein kinase domain; Region: Pkinase; pfam00069 378806012735 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806012736 active site 378806012737 ATP binding site [chemical binding]; other site 378806012738 substrate binding site [chemical binding]; other site 378806012739 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806012740 substrate binding site [chemical binding]; other site 378806012741 activation loop (A-loop); other site 378806012742 activation loop (A-loop); other site 378806012743 Predicted ATPase [General function prediction only]; Region: COG3899 378806012744 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806012745 GAF domain; Region: GAF; cl00853 378806012746 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806012747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806012748 ATP binding site [chemical binding]; other site 378806012749 Mg2+ binding site [ion binding]; other site 378806012750 G-X-G motif; other site 378806012751 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 378806012752 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806012753 DNA binding site [nucleotide binding] 378806012754 Int/Topo IB signature motif; other site 378806012755 active site 378806012756 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 378806012757 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 378806012758 Glucose inhibited division protein A; Region: GIDA; pfam01134 378806012759 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 378806012760 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806012761 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806012762 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 378806012763 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 378806012764 DNA topoisomerase I; Validated; Region: PRK06599 378806012765 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 378806012766 active site 378806012767 interdomain interaction site; other site 378806012768 putative metal-binding site [ion binding]; other site 378806012769 nucleotide binding site [chemical binding]; other site 378806012770 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 378806012771 domain I; other site 378806012772 DNA binding groove [nucleotide binding] 378806012773 phosphate binding site [ion binding]; other site 378806012774 domain II; other site 378806012775 domain III; other site 378806012776 nucleotide binding site [chemical binding]; other site 378806012777 catalytic site [active] 378806012778 domain IV; other site 378806012779 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 378806012780 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 378806012781 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 378806012782 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 378806012783 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 378806012784 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 378806012785 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 378806012786 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 378806012787 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 378806012788 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 378806012789 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806012790 dimerization interface [polypeptide binding]; other site 378806012791 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806012792 GAF domain; Region: GAF; cl00853 378806012793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806012794 metal binding site [ion binding]; metal-binding site 378806012795 active site 378806012796 I-site; other site 378806012797 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 378806012798 oxyanion hole [active] 378806012799 active site 378806012800 catalytic triad [active] 378806012801 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 378806012802 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806012803 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806012804 protein binding site [polypeptide binding]; other site 378806012805 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806012806 protein binding site [polypeptide binding]; other site 378806012807 Uncharacterized conserved protein [Function unknown]; Region: COG1543 378806012808 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 378806012809 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 378806012810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 378806012811 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806012812 Response regulator receiver domain; Region: Response_reg; pfam00072 378806012813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806012814 active site 378806012815 phosphorylation site [posttranslational modification] 378806012816 intermolecular recognition site; other site 378806012817 dimerization interface [polypeptide binding]; other site 378806012818 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806012819 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806012820 hypothetical protein; Validated; Region: PRK09039 378806012821 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806012822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806012823 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 378806012824 Walker A motif; other site 378806012825 ATP binding site [chemical binding]; other site 378806012826 Walker B motif; other site 378806012827 arginine finger; other site 378806012828 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 378806012829 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 378806012830 homodimer interface [polypeptide binding]; other site 378806012831 substrate-cofactor binding pocket; other site 378806012832 catalytic residue [active] 378806012833 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 378806012834 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806012835 Fic family protein [Function unknown]; Region: COG3177 378806012836 Fic/DOC family; Region: Fic; cl00960 378806012837 endonuclease IV; Provisional; Region: PRK01060 378806012838 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 378806012839 AP (apurinic/apyrimidinic) site pocket; other site 378806012840 DNA interaction; other site 378806012841 Metal-binding active site; metal-binding site 378806012842 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 378806012843 DHH family; Region: DHH; pfam01368 378806012844 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 378806012845 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806012846 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806012847 catalytic residue [active] 378806012848 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806012849 active site 378806012850 ATP binding site [chemical binding]; other site 378806012851 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806012852 substrate binding site [chemical binding]; other site 378806012853 activation loop (A-loop); other site 378806012854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806012855 binding surface 378806012856 TPR motif; other site 378806012857 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 378806012858 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 378806012859 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 378806012860 active site 378806012861 HIGH motif; other site 378806012862 dimer interface [polypeptide binding]; other site 378806012863 KMSKS motif; other site 378806012864 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378806012865 RNA binding surface [nucleotide binding]; other site 378806012866 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 378806012867 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806012868 structural tetrad; other site 378806012869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806012870 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 378806012871 active site 378806012872 ADP/pyrophosphate binding site [chemical binding]; other site 378806012873 dimerization interface [polypeptide binding]; other site 378806012874 allosteric effector site; other site 378806012875 fructose-1,6-bisphosphate binding site; other site 378806012876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806012877 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 378806012878 active site triad [active] 378806012879 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806012880 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806012881 active site 378806012882 acyl-CoA synthetase; Validated; Region: PRK09192 378806012883 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012884 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 378806012885 active site 378806012886 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 378806012887 dinuclear metal binding motif [ion binding]; other site 378806012888 CoA-transferase family III; Region: CoA_transf_3; cl00778 378806012889 SCP-2 sterol transfer family; Region: SCP2; cl01225 378806012890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806012891 Response regulator receiver domain; Region: Response_reg; pfam00072 378806012892 active site 378806012893 phosphorylation site [posttranslational modification] 378806012894 intermolecular recognition site; other site 378806012895 dimerization interface [polypeptide binding]; other site 378806012896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806012897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806012898 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 378806012899 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 378806012900 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806012901 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 378806012902 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 378806012903 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806012904 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806012905 FAD binding domain; Region: FAD_binding_4; pfam01565 378806012906 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 378806012907 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 378806012908 active site 378806012909 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806012910 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 378806012911 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 378806012912 intersubunit interface [polypeptide binding]; other site 378806012913 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 378806012914 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 378806012915 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 378806012916 putative PBP binding regions; other site 378806012917 ABC-ATPase subunit interface; other site 378806012918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 378806012919 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 378806012920 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 378806012921 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 378806012922 putative catalytic residue [active] 378806012923 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 378806012924 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 378806012925 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 378806012926 dimer interface [polypeptide binding]; other site 378806012927 [2Fe-2S] cluster binding site [ion binding]; other site 378806012928 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 378806012929 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 378806012930 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 378806012931 active site 378806012932 dimer interface [polypeptide binding]; other site 378806012933 effector binding site; other site 378806012934 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 378806012935 TSCPD domain; Region: TSCPD; cl14834 378806012936 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806012937 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 378806012938 Bacterial sugar transferase; Region: Bac_transf; cl00939 378806012939 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 378806012940 putative ADP-binding pocket [chemical binding]; other site 378806012941 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 378806012942 O-Antigen ligase; Region: Wzy_C; cl04850 378806012943 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 378806012944 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 378806012945 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 378806012946 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 378806012947 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 378806012948 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806012949 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 378806012950 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 378806012951 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806012952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806012953 TPR motif; other site 378806012954 binding surface 378806012955 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 378806012956 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 378806012957 purine monophosphate binding site [chemical binding]; other site 378806012958 dimer interface [polypeptide binding]; other site 378806012959 putative catalytic residues [active] 378806012960 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 378806012961 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 378806012962 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806012963 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806012964 active site 378806012965 ATP binding site [chemical binding]; other site 378806012966 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806012967 substrate binding site [chemical binding]; other site 378806012968 activation loop (A-loop); other site 378806012969 transcriptional regulator ICP4; Provisional; Region: PHA03307 378806012970 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806012971 active site 378806012972 ATP binding site [chemical binding]; other site 378806012973 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806012974 substrate binding site [chemical binding]; other site 378806012975 activation loop (A-loop); other site 378806012976 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 378806012977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806012978 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806012979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806012980 dimer interface [polypeptide binding]; other site 378806012981 phosphorylation site [posttranslational modification] 378806012982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806012983 ATP binding site [chemical binding]; other site 378806012984 Mg2+ binding site [ion binding]; other site 378806012985 G-X-G motif; other site 378806012986 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 378806012987 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 378806012988 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 378806012989 Protein kinase domain; Region: Pkinase; pfam00069 378806012990 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806012991 active site 378806012992 ATP binding site [chemical binding]; other site 378806012993 substrate binding site [chemical binding]; other site 378806012994 activation loop (A-loop); other site 378806012995 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 378806012996 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806012997 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 378806012998 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 378806012999 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 378806013000 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 378806013001 DNA binding site [nucleotide binding] 378806013002 active site 378806013003 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 378806013004 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 378806013005 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 378806013006 FAD binding domain; Region: FAD_binding_4; pfam01565 378806013007 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806013008 Zn binding site [ion binding]; other site 378806013009 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 378806013010 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 378806013011 Predicted acyl esterases [General function prediction only]; Region: COG2936 378806013012 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 378806013013 PAS domain S-box; Region: sensory_box; TIGR00229 378806013014 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806013015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806013016 ATP binding site [chemical binding]; other site 378806013017 Mg2+ binding site [ion binding]; other site 378806013018 G-X-G motif; other site 378806013019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806013020 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 378806013021 active site 378806013022 peptide synthase; Validated; Region: PRK05691 378806013023 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806013024 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806013025 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 378806013026 putative hydrophobic ligand binding site [chemical binding]; other site 378806013027 Cytochrome P450; Region: p450; cl12078 378806013028 Cytochrome P450; Region: p450; cl12078 378806013029 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806013030 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806013031 active site 378806013032 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806013033 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013034 PKS_DH; Region: PKS_DH; smart00826 378806013035 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806013036 putative NADP binding site [chemical binding]; other site 378806013037 active site 378806013038 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013039 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806013040 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806013041 active site 378806013042 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013043 PKS_DH; Region: PKS_DH; smart00826 378806013044 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806013045 putative NADP binding site [chemical binding]; other site 378806013046 active site 378806013047 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013048 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806013049 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806013050 active site 378806013051 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806013052 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013053 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806013054 putative NADP binding site [chemical binding]; other site 378806013055 active site 378806013056 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013057 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806013058 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806013059 active site 378806013060 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013061 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013063 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 378806013064 Enoylreductase; Region: PKS_ER; smart00829 378806013065 NAD(P) binding site [chemical binding]; other site 378806013066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013067 NAD(P) binding site [chemical binding]; other site 378806013068 active site 378806013069 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013070 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806013071 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806013072 active site 378806013073 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013074 PKS_DH; Region: PKS_DH; smart00826 378806013075 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806013076 putative NADP binding site [chemical binding]; other site 378806013077 active site 378806013078 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013079 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806013080 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 378806013081 active site 378806013082 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806013083 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013084 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 378806013085 NADP binding site [chemical binding]; other site 378806013086 active site 378806013087 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013088 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806013089 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806013090 active site 378806013091 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013092 PKS_DH; Region: PKS_DH; smart00826 378806013093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013094 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 378806013095 Enoylreductase; Region: PKS_ER; smart00829 378806013096 NAD(P) binding site [chemical binding]; other site 378806013097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013098 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013099 Cytochrome P450; Region: p450; cl12078 378806013100 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013101 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806013102 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806013103 active site 378806013104 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013105 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806013106 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013107 PKS_DH; Region: PKS_DH; smart00826 378806013108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013109 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 378806013110 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 378806013111 NAD(P) binding site [chemical binding]; other site 378806013112 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806013113 putative NADP binding site [chemical binding]; other site 378806013114 active site 378806013115 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013116 hypothetical protein; Provisional; Region: PRK06184 378806013117 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806013118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806013119 Integrase core domain; Region: rve; cl01316 378806013120 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806013121 Integrase core domain; Region: rve; cl01316 378806013122 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806013123 Int/Topo IB signature motif; other site 378806013124 DNA binding site [nucleotide binding] 378806013125 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 378806013126 substrate binding site [chemical binding]; other site 378806013127 dimer interface [polypeptide binding]; other site 378806013128 catalytic triad [active] 378806013129 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 378806013130 substrate binding site [chemical binding]; other site 378806013131 hinge regions; other site 378806013132 ADP binding site [chemical binding]; other site 378806013133 catalytic site [active] 378806013134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013135 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 378806013136 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 378806013137 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 378806013138 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 378806013139 active site 378806013140 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 378806013141 Interdomain contacts; other site 378806013142 Cytokine receptor motif; other site 378806013143 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 378806013144 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 378806013145 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806013146 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 378806013147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806013148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806013149 S-adenosylmethionine binding site [chemical binding]; other site 378806013150 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 378806013151 generic binding surface II; other site 378806013152 generic binding surface I; other site 378806013153 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 378806013154 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806013155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 378806013156 Zn2+ binding site [ion binding]; other site 378806013157 Mg2+ binding site [ion binding]; other site 378806013158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806013159 active site 378806013160 phosphorylation site [posttranslational modification] 378806013161 intermolecular recognition site; other site 378806013162 dimerization interface [polypeptide binding]; other site 378806013163 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 378806013164 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 378806013165 active site 378806013166 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806013167 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 378806013168 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 378806013169 active site 378806013170 HIGH motif; other site 378806013171 KMSKS motif; other site 378806013172 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 378806013173 tRNA binding surface [nucleotide binding]; other site 378806013174 anticodon binding site; other site 378806013175 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 378806013176 dimer interface [polypeptide binding]; other site 378806013177 putative tRNA-binding site [nucleotide binding]; other site 378806013178 Protein of unknown function (DUF833); Region: DUF833; cl01315 378806013179 Response regulator receiver domain; Region: Response_reg; pfam00072 378806013180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806013181 active site 378806013182 phosphorylation site [posttranslational modification] 378806013183 intermolecular recognition site; other site 378806013184 dimerization interface [polypeptide binding]; other site 378806013185 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 378806013186 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 378806013187 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 378806013188 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 378806013189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806013190 Mechanosensitive ion channel; Region: MS_channel; pfam00924 378806013191 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806013192 ligand binding site [chemical binding]; other site 378806013193 flexible hinge region; other site 378806013194 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 378806013195 active site 378806013196 metal binding site [ion binding]; metal-binding site 378806013197 Response regulator receiver domain; Region: Response_reg; pfam00072 378806013198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806013199 active site 378806013200 phosphorylation site [posttranslational modification] 378806013201 intermolecular recognition site; other site 378806013202 dimerization interface [polypeptide binding]; other site 378806013203 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806013204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806013205 ATP binding site [chemical binding]; other site 378806013206 Mg2+ binding site [ion binding]; other site 378806013207 G-X-G motif; other site 378806013208 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 378806013209 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806013210 putative peptidoglycan binding site; other site 378806013211 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 378806013212 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 378806013213 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806013214 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 378806013215 putative C-terminal domain interface [polypeptide binding]; other site 378806013216 putative GSH binding site (G-site) [chemical binding]; other site 378806013217 putative dimer interface [polypeptide binding]; other site 378806013218 GST_C family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_C_GTT1_like; cd03189 378806013219 putative N-terminal domain interface [polypeptide binding]; other site 378806013220 putative dimer interface [polypeptide binding]; other site 378806013221 putative substrate binding pocket (H-site) [chemical binding]; other site 378806013222 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 378806013223 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 378806013224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806013225 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806013226 active site 378806013227 acyl-CoA ligase (AMP-forming), exosortase system type 1 associated; Region: ligase_PEP_1; TIGR03098 378806013228 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806013229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806013230 putative substrate translocation pore; other site 378806013231 Cupin domain; Region: Cupin_2; cl09118 378806013232 LysR family transcriptional regulator; Provisional; Region: PRK14997 378806013233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806013234 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 378806013235 putative effector binding pocket; other site 378806013236 dimerization interface [polypeptide binding]; other site 378806013237 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 378806013238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013239 NAD(P) binding site [chemical binding]; other site 378806013240 active site 378806013241 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 378806013242 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 378806013243 FtsX-like permease family; Region: FtsX; pfam02687 378806013244 FtsX-like permease family; Region: FtsX; pfam02687 378806013245 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378806013246 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 378806013247 Walker A/P-loop; other site 378806013248 ATP binding site [chemical binding]; other site 378806013249 Q-loop/lid; other site 378806013250 ABC transporter signature motif; other site 378806013251 Walker B; other site 378806013252 D-loop; other site 378806013253 H-loop/switch region; other site 378806013254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806013255 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 378806013256 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 378806013257 ATP binding site [chemical binding]; other site 378806013258 Mg++ binding site [ion binding]; other site 378806013259 motif III; other site 378806013260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806013261 nucleotide binding region [chemical binding]; other site 378806013262 ATP-binding site [chemical binding]; other site 378806013263 DbpA RNA binding domain; Region: DbpA; pfam03880 378806013264 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 378806013265 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 378806013266 active site 378806013267 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806013268 PKS_DH; Region: PKS_DH; smart00826 378806013269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013270 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 378806013271 Enoylreductase; Region: PKS_ER; smart00829 378806013272 NAD(P) binding site [chemical binding]; other site 378806013273 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 378806013274 putative NADP binding site [chemical binding]; other site 378806013275 active site 378806013276 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806013277 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806013278 Thioesterase domain; Region: Thioesterase; pfam00975 378806013279 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 378806013280 active site 378806013281 catalytic residues [active] 378806013282 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 378806013283 metal binding site [ion binding]; metal-binding site 378806013284 ligand binding site [chemical binding]; other site 378806013285 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 378806013286 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 378806013287 dimer interface [polypeptide binding]; other site 378806013288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806013289 catalytic residue [active] 378806013290 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 378806013291 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806013292 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806013293 active site 378806013294 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 378806013295 heme binding pocket [chemical binding]; other site 378806013296 GAF domain; Region: GAF; cl00853 378806013297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806013298 DNA binding residues [nucleotide binding] 378806013299 dimerization interface [polypeptide binding]; other site 378806013300 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378806013301 catalytic core [active] 378806013302 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 378806013303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806013304 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 378806013305 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 378806013306 Ca2+ binding site [ion binding]; other site 378806013307 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806013308 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 378806013309 active site 378806013310 metal binding site [ion binding]; metal-binding site 378806013311 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 378806013312 homodimer interface [polypeptide binding]; other site 378806013313 homotetramer interface [polypeptide binding]; other site 378806013314 active site pocket [active] 378806013315 cleavage site 378806013316 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 378806013317 Predicted membrane protein [Function unknown]; Region: COG2119 378806013318 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 378806013319 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 378806013320 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806013321 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_subtilisin_1; cd04818 378806013322 PA/protease or protease-like domain interface [polypeptide binding]; other site 378806013323 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 378806013324 Zn binding site [ion binding]; other site 378806013325 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 378806013326 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 378806013327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806013328 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 378806013329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 378806013330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 378806013331 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 378806013332 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806013333 UvrD/REP helicase; Region: UvrD-helicase; cl14126 378806013334 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 378806013335 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 378806013336 Protein kinase; unclassified specificity; Region: STYKc; smart00221 378806013337 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806013338 substrate binding site [chemical binding]; other site 378806013339 activation loop (A-loop); other site 378806013340 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 378806013341 active site 378806013342 dimer interface [polypeptide binding]; other site 378806013343 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 378806013344 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 378806013345 dimer interface [polypeptide binding]; other site 378806013346 active site 378806013347 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 378806013348 dimer interface [polypeptide binding]; other site 378806013349 active site 378806013350 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 378806013351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806013352 DNA-binding site [nucleotide binding]; DNA binding site 378806013353 UTRA domain; Region: UTRA; cl06649 378806013354 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 378806013355 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 378806013356 putative active site [active] 378806013357 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 378806013358 HPr interaction site; other site 378806013359 glycerol kinase (GK) interaction site [polypeptide binding]; other site 378806013360 active site 378806013361 phosphorylation site [posttranslational modification] 378806013362 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 378806013363 dimerization domain swap beta strand [polypeptide binding]; other site 378806013364 regulatory protein interface [polypeptide binding]; other site 378806013365 active site 378806013366 regulatory phosphorylation site [posttranslational modification]; other site 378806013367 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 378806013368 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 378806013369 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 378806013370 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 378806013371 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 378806013372 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 378806013373 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 378806013374 active site turn [active] 378806013375 phosphorylation site [posttranslational modification] 378806013376 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 378806013377 active site turn [active] 378806013378 phosphorylation site [posttranslational modification] 378806013379 Putative carbohydrate binding domain; Region: CHB_HEX; pfam03173 378806013380 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 378806013381 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 378806013382 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_Sm-chitobiase-like; cd06569 378806013383 active site 378806013384 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 378806013385 RNA polymerase sigma factor; Provisional; Region: PRK11922 378806013386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806013387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806013388 Cellulose binding domain; Region: CBM_2; cl02709 378806013389 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 378806013390 active site 378806013391 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 378806013392 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 378806013393 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 378806013394 putative active site [active] 378806013395 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 378806013396 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 378806013397 putative alpha-glucosidase; Provisional; Region: PRK10658 378806013398 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 378806013399 trimer interface [polypeptide binding]; other site 378806013400 active site 378806013401 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 378806013402 catalytic site [active] 378806013403 thiamine pyrophosphate protein; Provisional; Region: PRK08273 378806013404 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 378806013405 PYR/PP interface [polypeptide binding]; other site 378806013406 tetramer interface [polypeptide binding]; other site 378806013407 dimer interface [polypeptide binding]; other site 378806013408 TPP binding site [chemical binding]; other site 378806013409 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378806013410 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 378806013411 TPP-binding site [chemical binding]; other site 378806013412 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 378806013413 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806013414 Cytochrome P450; Region: p450; cl12078 378806013415 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 378806013416 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 378806013417 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 378806013418 putative active site [active] 378806013419 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806013420 phosphopeptide binding site; other site 378806013421 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806013422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806013423 Walker A motif; other site 378806013424 ATP binding site [chemical binding]; other site 378806013425 Walker B motif; other site 378806013426 arginine finger; other site 378806013427 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806013428 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806013429 active site 378806013430 ATP binding site [chemical binding]; other site 378806013431 substrate binding site [chemical binding]; other site 378806013432 activation loop (A-loop); other site 378806013433 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806013434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806013435 binding surface 378806013436 TPR motif; other site 378806013437 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806013438 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806013439 catalytic residue [active] 378806013440 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 378806013441 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 378806013442 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806013443 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806013444 active site 378806013445 catalytic tetrad [active] 378806013446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806013447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806013448 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 378806013449 putative ArsC-like catalytic residues; other site 378806013450 putative TRX-like catalytic residues [active] 378806013451 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806013452 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 378806013453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806013454 catalytic residue [active] 378806013455 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806013456 active site 378806013457 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 378806013458 nudix motif; other site 378806013459 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 378806013460 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 378806013461 dimer interface [polypeptide binding]; other site 378806013462 active site 378806013463 Uncharacterized conserved protein [Function unknown]; Region: COG4715 378806013464 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 378806013465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806013466 ATP binding site [chemical binding]; other site 378806013467 putative Mg++ binding site [ion binding]; other site 378806013468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806013469 nucleotide binding region [chemical binding]; other site 378806013470 ATP-binding site [chemical binding]; other site 378806013471 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 378806013472 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 378806013473 dimer interface [polypeptide binding]; other site 378806013474 NAD binding site [chemical binding]; other site 378806013475 substrate binding site [chemical binding]; other site 378806013476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 378806013477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806013478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806013479 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806013480 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 378806013481 putative NAD(P) binding site [chemical binding]; other site 378806013482 putative active site [active] 378806013483 LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235 378806013484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806013485 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 378806013486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806013487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 378806013488 dimerization interface [polypeptide binding]; other site 378806013489 acetolactate synthase; Reviewed; Region: PRK08322 378806013490 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 378806013491 PYR/PP interface [polypeptide binding]; other site 378806013492 dimer interface [polypeptide binding]; other site 378806013493 TPP binding site [chemical binding]; other site 378806013494 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378806013495 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 378806013496 TPP-binding site [chemical binding]; other site 378806013497 dimer interface [polypeptide binding]; other site 378806013498 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 378806013499 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806013500 NAD(P) binding site [chemical binding]; other site 378806013501 catalytic residues [active] 378806013502 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 378806013503 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 378806013504 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 378806013505 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 378806013506 NADP binding site [chemical binding]; other site 378806013507 active site 378806013508 steroid binding site; other site 378806013509 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 378806013510 putative hydrophobic ligand binding site [chemical binding]; other site 378806013511 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378806013512 dimerization interface [polypeptide binding]; other site 378806013513 putative DNA binding site [nucleotide binding]; other site 378806013514 putative Zn2+ binding site [ion binding]; other site 378806013515 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 378806013516 Domain interface; other site 378806013517 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 378806013518 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 378806013519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806013520 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 378806013521 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 378806013522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806013523 binding surface 378806013524 TPR motif; other site 378806013525 Bacterial SH3 domain; Region: SH3_3; cl02551 378806013526 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806013527 active site 378806013528 ATP binding site [chemical binding]; other site 378806013529 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806013530 substrate binding site [chemical binding]; other site 378806013531 activation loop (A-loop); other site 378806013532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806013533 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806013534 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806013535 hypothetical protein; Provisional; Region: PRK05590 378806013536 SEC-C motif; Region: SEC-C; cl12132 378806013537 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806013538 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 378806013539 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 378806013540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 378806013541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806013542 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 378806013543 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 378806013544 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 378806013545 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 378806013546 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 378806013547 Walker A/P-loop; other site 378806013548 ATP binding site [chemical binding]; other site 378806013549 Q-loop/lid; other site 378806013550 ABC transporter signature motif; other site 378806013551 Walker B; other site 378806013552 D-loop; other site 378806013553 H-loop/switch region; other site 378806013554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 378806013555 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 378806013556 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 378806013557 Walker A/P-loop; other site 378806013558 ATP binding site [chemical binding]; other site 378806013559 Q-loop/lid; other site 378806013560 ABC transporter signature motif; other site 378806013561 Walker B; other site 378806013562 D-loop; other site 378806013563 H-loop/switch region; other site 378806013564 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 378806013565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806013566 dimer interface [polypeptide binding]; other site 378806013567 conserved gate region; other site 378806013568 putative PBP binding loops; other site 378806013569 ABC-ATPase subunit interface; other site 378806013570 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 378806013571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806013572 dimer interface [polypeptide binding]; other site 378806013573 conserved gate region; other site 378806013574 putative PBP binding loops; other site 378806013575 ABC-ATPase subunit interface; other site 378806013576 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 378806013577 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 378806013578 substrate binding site [chemical binding]; other site 378806013579 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 378806013580 CHAT domain; Region: CHAT; cl02083 378806013581 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806013582 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806013583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806013584 putative substrate translocation pore; other site 378806013585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378806013586 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 378806013587 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806013588 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806013589 Integrase core domain; Region: rve; cl01316 378806013590 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 378806013591 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806013592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806013593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806013594 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806013595 DNA binding site [nucleotide binding] 378806013596 active site 378806013597 Int/Topo IB signature motif; other site 378806013598 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 378806013599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806013600 TPR motif; other site 378806013601 binding surface 378806013602 Protein of unknown function DUF124; Region: DUF124; cl00884 378806013603 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806013604 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806013605 catalytic residue [active] 378806013606 L-aspartate oxidase; Provisional; Region: PRK09077 378806013607 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806013608 domain; Region: Succ_DH_flav_C; pfam02910 378806013609 Rhomboid family; Region: Rhomboid; cl11446 378806013610 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 378806013611 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806013612 ParB-like nuclease domain; Region: ParBc; cl02129 378806013613 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 378806013614 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 378806013615 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 378806013616 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 378806013617 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806013618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806013619 TPR motif; other site 378806013620 binding surface 378806013621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806013622 binding surface 378806013623 TPR motif; other site 378806013624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806013625 binding surface 378806013626 TPR motif; other site 378806013627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806013628 binding surface 378806013629 TPR motif; other site 378806013630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806013631 binding surface 378806013632 TPR motif; other site 378806013633 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806013634 GAF domain; Region: GAF; cl00853 378806013635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806013636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806013637 ATP binding site [chemical binding]; other site 378806013638 Mg2+ binding site [ion binding]; other site 378806013639 G-X-G motif; other site 378806013640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806013641 active site 378806013642 phosphorylation site [posttranslational modification] 378806013643 intermolecular recognition site; other site 378806013644 dimerization interface [polypeptide binding]; other site 378806013645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806013646 metal binding site [ion binding]; metal-binding site 378806013647 active site 378806013648 I-site; other site 378806013649 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806013650 ligand binding site [chemical binding]; other site 378806013651 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 378806013652 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 378806013653 2,3-oxidosqualene cyclase; Region: osq_cycl; TIGR03463 378806013654 Active site cavity [active] 378806013655 catalytic acid [active] 378806013656 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 378806013657 active site lid residues [active] 378806013658 substrate binding pocket [chemical binding]; other site 378806013659 catalytic residues [active] 378806013660 substrate-Mg2+ binding site; other site 378806013661 aspartate-rich region 1; other site 378806013662 aspartate-rich region 2; other site 378806013663 squalene epoxidase; Provisional; Region: PTZ00367 378806013664 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806013665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 378806013666 TM-ABC transporter signature motif; other site 378806013667 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 378806013668 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 378806013669 Walker A/P-loop; other site 378806013670 ATP binding site [chemical binding]; other site 378806013671 Q-loop/lid; other site 378806013672 ABC transporter signature motif; other site 378806013673 Walker B; other site 378806013674 D-loop; other site 378806013675 H-loop/switch region; other site 378806013676 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 378806013677 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 378806013678 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 378806013679 ligand binding site [chemical binding]; other site 378806013680 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 378806013681 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378806013682 RNA binding surface [nucleotide binding]; other site 378806013683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806013684 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 378806013685 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 378806013686 TPP-binding site; other site 378806013687 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 378806013688 PYR/PP interface [polypeptide binding]; other site 378806013689 dimer interface [polypeptide binding]; other site 378806013690 TPP binding site [chemical binding]; other site 378806013691 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 378806013692 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 378806013693 substrate binding pocket [chemical binding]; other site 378806013694 chain length determination region; other site 378806013695 substrate-Mg2+ binding site; other site 378806013696 catalytic residues [active] 378806013697 aspartate-rich region 1; other site 378806013698 active site lid residues [active] 378806013699 aspartate-rich region 2; other site 378806013700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806013701 active site 378806013702 phosphorylation site [posttranslational modification] 378806013703 intermolecular recognition site; other site 378806013704 dimerization interface [polypeptide binding]; other site 378806013705 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 378806013706 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 378806013707 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 378806013708 generic binding surface II; other site 378806013709 generic binding surface I; other site 378806013710 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 378806013711 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806013712 phosphopeptide binding site; other site 378806013713 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806013714 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 378806013715 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 378806013716 SAF domain; Region: SAF; cl00555 378806013717 TadE-like protein; Region: TadE; pfam07811 378806013718 TadE-like protein; Region: TadE; pfam07811 378806013719 Cupin domain; Region: Cupin_2; cl09118 378806013720 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806013721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806013722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806013723 DNA binding residues [nucleotide binding] 378806013724 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 378806013725 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 378806013726 Walker A/P-loop; other site 378806013727 ATP binding site [chemical binding]; other site 378806013728 Q-loop/lid; other site 378806013729 ABC transporter signature motif; other site 378806013730 Walker B; other site 378806013731 D-loop; other site 378806013732 H-loop/switch region; other site 378806013733 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 378806013734 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 378806013735 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 378806013736 Walker A/P-loop; other site 378806013737 ATP binding site [chemical binding]; other site 378806013738 Q-loop/lid; other site 378806013739 ABC transporter signature motif; other site 378806013740 Walker B; other site 378806013741 D-loop; other site 378806013742 H-loop/switch region; other site 378806013743 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 378806013744 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806013745 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 378806013746 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806013747 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 378806013748 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806013749 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 378806013750 MgtE intracellular N domain; Region: MgtE_N; cl15244 378806013751 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 378806013752 Divalent cation transporter; Region: MgtE; cl00786 378806013753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806013754 dimer interface [polypeptide binding]; other site 378806013755 phosphorylation site [posttranslational modification] 378806013756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806013757 ATP binding site [chemical binding]; other site 378806013758 Mg2+ binding site [ion binding]; other site 378806013759 G-X-G motif; other site 378806013760 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806013761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806013762 active site 378806013763 phosphorylation site [posttranslational modification] 378806013764 intermolecular recognition site; other site 378806013765 dimerization interface [polypeptide binding]; other site 378806013766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806013767 Walker A motif; other site 378806013768 ATP binding site [chemical binding]; other site 378806013769 Walker B motif; other site 378806013770 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806013771 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 378806013772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806013773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806013774 transcriptional activator TtdR; Provisional; Region: PRK09801 378806013775 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 378806013776 putative effector binding pocket; other site 378806013777 dimerization interface [polypeptide binding]; other site 378806013778 NeuB family; Region: NeuB; cl00496 378806013779 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 378806013780 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 378806013781 Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794 378806013782 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 378806013783 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806013784 active site 378806013785 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 378806013786 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 378806013787 active site 378806013788 catalytic site [active] 378806013789 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 378806013790 active site 378806013791 catalytic site [active] 378806013792 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 378806013793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806013795 active site 378806013796 phosphorylation site [posttranslational modification] 378806013797 intermolecular recognition site; other site 378806013798 dimerization interface [polypeptide binding]; other site 378806013799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 378806013800 Zn2+ binding site [ion binding]; other site 378806013801 Mg2+ binding site [ion binding]; other site 378806013802 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806013803 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 378806013804 active site 378806013805 MoxR-like ATPases [General function prediction only]; Region: COG0714 378806013806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806013807 Walker A motif; other site 378806013808 ATP binding site [chemical binding]; other site 378806013809 Walker B motif; other site 378806013810 arginine finger; other site 378806013811 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 378806013812 Protein of unknown function DUF58; Region: DUF58; pfam01882 378806013813 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 378806013814 metal ion-dependent adhesion site (MIDAS); other site 378806013815 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378806013816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806013817 ATP binding site [chemical binding]; other site 378806013818 putative Mg++ binding site [ion binding]; other site 378806013819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806013820 nucleotide binding region [chemical binding]; other site 378806013821 ATP-binding site [chemical binding]; other site 378806013822 Smr domain; Region: Smr; cl02619 378806013823 Protein of unknown function DUF72; Region: DUF72; cl00777 378806013824 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806013825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806013826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806013827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806013828 Surface antigen; Region: Bac_surface_Ag; cl03097 378806013829 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 378806013830 substrate binding site [chemical binding]; other site 378806013831 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 378806013832 active site 378806013833 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 378806013834 dimer interface [polypeptide binding]; other site 378806013835 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 378806013836 Ligand Binding Site [chemical binding]; other site 378806013837 Molecular Tunnel; other site 378806013838 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 378806013839 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 378806013840 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 378806013841 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 378806013842 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 378806013843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806013844 DNA-binding site [nucleotide binding]; DNA binding site 378806013845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806013846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806013847 homodimer interface [polypeptide binding]; other site 378806013848 catalytic residue [active] 378806013849 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 378806013850 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 378806013851 dimer interface [polypeptide binding]; other site 378806013852 anticodon binding site; other site 378806013853 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 378806013854 homodimer interface [polypeptide binding]; other site 378806013855 motif 1; other site 378806013856 active site 378806013857 motif 2; other site 378806013858 GAD domain; Region: GAD; pfam02938 378806013859 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 378806013860 active site 378806013861 motif 3; other site 378806013862 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806013863 Zn binding site [ion binding]; other site 378806013864 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 378806013865 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 378806013866 DHH family; Region: DHH; pfam01368 378806013867 DHHA1 domain; Region: DHHA1; pfam02272 378806013868 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 378806013869 putative active site [active] 378806013870 catalytic site [active] 378806013871 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 378806013872 putative active site [active] 378806013873 catalytic site [active] 378806013874 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 378806013875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806013876 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 378806013877 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806013878 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378806013879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806013880 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 378806013881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806013882 Phage integrase family; Region: Phage_integrase; pfam00589 378806013883 DNA binding site [nucleotide binding] 378806013884 Int/Topo IB signature motif; other site 378806013885 active site 378806013886 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378806013887 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806013888 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806013889 Integrase core domain; Region: rve; cl01316 378806013890 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806013891 Integrase core domain; Region: rve; cl01316 378806013892 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806013893 Transposase domain (DUF772); Region: DUF772; cl12084 378806013894 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806013895 metal binding site [ion binding]; metal-binding site 378806013896 Nudix hydrolase homolog; Region: PLN02791 378806013897 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 378806013898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806013899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806013900 active site 378806013901 ATP binding site [chemical binding]; other site 378806013902 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806013903 substrate binding site [chemical binding]; other site 378806013904 activation loop (A-loop); other site 378806013905 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806013906 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 378806013907 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 378806013908 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 378806013909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806013910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806013911 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 378806013912 NADP binding site [chemical binding]; other site 378806013913 active site 378806013914 regulatory binding site [polypeptide binding]; other site 378806013915 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 378806013916 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 378806013917 active site residue [active] 378806013918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 378806013919 active site residue [active] 378806013920 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 378806013921 active site residue [active] 378806013922 Uncharacterized conserved protein [Function unknown]; Region: COG3482 378806013923 TfuA-like protein; Region: TfuA; pfam07812 378806013924 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806013925 phosphopeptide binding site; other site 378806013926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806013927 Walker A motif; other site 378806013928 ATP binding site [chemical binding]; other site 378806013929 Walker B motif; other site 378806013930 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806013931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806013932 DNA-binding site [nucleotide binding]; DNA binding site 378806013933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806013934 dimer interface [polypeptide binding]; other site 378806013935 phosphorylation site [posttranslational modification] 378806013936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806013937 ATP binding site [chemical binding]; other site 378806013938 Mg2+ binding site [ion binding]; other site 378806013939 G-X-G motif; other site 378806013940 Hsp70 protein; Region: HSP70; pfam00012 378806013941 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 378806013942 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 378806013943 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 378806013944 Protein export membrane protein; Region: SecD_SecF; cl14618 378806013945 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 378806013946 Protein export membrane protein; Region: SecD_SecF; cl14618 378806013947 Preprotein translocase subunit; Region: YajC; cl00806 378806013948 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 378806013949 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 378806013950 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 378806013951 Stage II sporulation protein; Region: SpoIID; cl07201 378806013952 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 378806013953 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 378806013954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806013955 FeS/SAM binding site; other site 378806013956 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 378806013957 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806013958 Protein kinase domain; Region: Pkinase; pfam00069 378806013959 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806013960 active site 378806013961 ATP binding site [chemical binding]; other site 378806013962 substrate binding site [chemical binding]; other site 378806013963 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806013964 substrate binding site [chemical binding]; other site 378806013965 activation loop (A-loop); other site 378806013966 activation loop (A-loop); other site 378806013967 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 378806013968 catalytic site [active] 378806013969 G-X2-G-X-G-K; other site 378806013970 hypothetical protein; Provisional; Region: PRK11820 378806013971 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 378806013972 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 378806013973 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 378806013974 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 378806013975 putative active site [active] 378806013976 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806013977 active site 378806013978 nucleotide binding site [chemical binding]; other site 378806013979 HIGH motif; other site 378806013980 KMSKS motif; other site 378806013981 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 378806013982 substrate binding site [chemical binding]; other site 378806013983 ATP binding site [chemical binding]; other site 378806013984 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 378806013985 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806013986 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806013987 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 378806013988 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 378806013989 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806013990 PHP domain; Region: PHP; pfam02811 378806013991 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 378806013992 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 378806013993 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 378806013994 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806013995 Walker A/P-loop; other site 378806013996 ATP binding site [chemical binding]; other site 378806013997 Q-loop/lid; other site 378806013998 ABC transporter signature motif; other site 378806013999 Walker B; other site 378806014000 D-loop; other site 378806014001 H-loop/switch region; other site 378806014002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806014003 active site 378806014004 phosphorylation site [posttranslational modification] 378806014005 intermolecular recognition site; other site 378806014006 dimerization interface [polypeptide binding]; other site 378806014007 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 378806014008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014009 binding surface 378806014010 TPR motif; other site 378806014011 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 378806014012 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 378806014013 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 378806014014 Ligand binding site [chemical binding]; other site 378806014015 Putative Catalytic site [active] 378806014016 DXD motif; other site 378806014017 MarC family integral membrane protein; Region: MarC; cl00919 378806014018 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806014019 ligand binding site [chemical binding]; other site 378806014020 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 378806014021 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 378806014022 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 378806014023 active site 378806014024 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 378806014025 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 378806014026 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 378806014027 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 378806014028 trimer interface [polypeptide binding]; other site 378806014029 active site 378806014030 UDP-GlcNAc binding site [chemical binding]; other site 378806014031 lipid binding site [chemical binding]; lipid-binding site 378806014032 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 378806014033 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806014034 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 378806014035 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806014036 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806014037 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806014038 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806014039 Surface antigen; Region: Bac_surface_Ag; cl03097 378806014040 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 378806014041 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 378806014042 Walker A/P-loop; other site 378806014043 ATP binding site [chemical binding]; other site 378806014044 Q-loop/lid; other site 378806014045 ABC transporter signature motif; other site 378806014046 Walker B; other site 378806014047 D-loop; other site 378806014048 H-loop/switch region; other site 378806014049 LolC/E family; Region: lolCE; TIGR02212 378806014050 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 378806014051 FtsX-like permease family; Region: FtsX; pfam02687 378806014052 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 378806014053 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 378806014054 dimer interface [polypeptide binding]; other site 378806014055 putative anticodon binding site; other site 378806014056 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 378806014057 motif 1; other site 378806014058 active site 378806014059 motif 2; other site 378806014060 motif 3; other site 378806014061 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 378806014062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806014063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806014064 DNA binding residues [nucleotide binding] 378806014065 peptide chain release factor 2; Validated; Region: prfB; PRK00578 378806014066 RF-1 domain; Region: RF-1; cl02875 378806014067 RF-1 domain; Region: RF-1; cl02875 378806014068 Cupin domain; Region: Cupin_2; cl09118 378806014069 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 378806014070 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 378806014071 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 378806014072 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 378806014073 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 378806014074 Zn2+ binding site [ion binding]; other site 378806014075 Mg2+ binding site [ion binding]; other site 378806014076 PhoH-like protein; Region: PhoH; cl12134 378806014077 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 378806014078 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 378806014079 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 378806014080 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 378806014081 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 378806014082 active site 378806014083 metal binding site [ion binding]; metal-binding site 378806014084 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 378806014085 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 378806014086 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 378806014087 HIGH motif; other site 378806014088 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806014089 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806014090 active site 378806014091 KMSKS motif; other site 378806014092 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 378806014093 tRNA binding surface [nucleotide binding]; other site 378806014094 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 378806014095 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 378806014096 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 378806014097 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 378806014098 Walker A/P-loop; other site 378806014099 ATP binding site [chemical binding]; other site 378806014100 Q-loop/lid; other site 378806014101 ABC transporter signature motif; other site 378806014102 Walker B; other site 378806014103 D-loop; other site 378806014104 H-loop/switch region; other site 378806014105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014106 Response regulator receiver domain; Region: Response_reg; pfam00072 378806014107 active site 378806014108 phosphorylation site [posttranslational modification] 378806014109 intermolecular recognition site; other site 378806014110 dimerization interface [polypeptide binding]; other site 378806014111 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 378806014112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014113 active site 378806014114 phosphorylation site [posttranslational modification] 378806014115 intermolecular recognition site; other site 378806014116 dimerization interface [polypeptide binding]; other site 378806014117 CheB methylesterase; Region: CheB_methylest; pfam01339 378806014118 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 378806014119 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 378806014120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806014121 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 378806014122 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 378806014123 putative CheA interaction surface; other site 378806014124 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806014125 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 378806014126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806014127 ATP binding site [chemical binding]; other site 378806014128 Mg2+ binding site [ion binding]; other site 378806014129 G-X-G motif; other site 378806014130 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 378806014131 Response regulator receiver domain; Region: Response_reg; pfam00072 378806014132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014133 active site 378806014134 phosphorylation site [posttranslational modification] 378806014135 intermolecular recognition site; other site 378806014136 dimerization interface [polypeptide binding]; other site 378806014137 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cl08294 378806014138 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 378806014139 putative RNA binding site [nucleotide binding]; other site 378806014140 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 378806014141 homopentamer interface [polypeptide binding]; other site 378806014142 active site 378806014143 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 378806014144 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 378806014145 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 378806014146 dimerization interface [polypeptide binding]; other site 378806014147 active site 378806014148 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 378806014149 Lumazine binding domain; Region: Lum_binding; pfam00677 378806014150 Lumazine binding domain; Region: Lum_binding; pfam00677 378806014151 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 378806014152 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 378806014153 catalytic motif [active] 378806014154 Zn binding site [ion binding]; other site 378806014155 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806014156 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 378806014157 ATP cone domain; Region: ATP-cone; pfam03477 378806014158 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 378806014159 dimer interface [polypeptide binding]; other site 378806014160 glycine-pyridoxal phosphate binding site [chemical binding]; other site 378806014161 active site 378806014162 folate binding site [chemical binding]; other site 378806014163 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 378806014164 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 378806014165 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 378806014166 dimer interface [polypeptide binding]; other site 378806014167 active site 378806014168 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806014169 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 378806014170 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 378806014171 NAD(P) binding site [chemical binding]; other site 378806014172 homotetramer interface [polypeptide binding]; other site 378806014173 homodimer interface [polypeptide binding]; other site 378806014174 active site 378806014175 Acyl transferase domain; Region: Acyl_transf_1; cl08282 378806014176 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378806014177 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 378806014178 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 378806014179 dimer interface [polypeptide binding]; other site 378806014180 active site 378806014181 CoA binding pocket [chemical binding]; other site 378806014182 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 378806014183 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 378806014184 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 378806014185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014186 active site 378806014187 phosphorylation site [posttranslational modification] 378806014188 intermolecular recognition site; other site 378806014189 dimerization interface [polypeptide binding]; other site 378806014190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806014191 DNA binding site [nucleotide binding] 378806014192 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806014193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806014194 dimer interface [polypeptide binding]; other site 378806014195 phosphorylation site [posttranslational modification] 378806014196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806014197 ATP binding site [chemical binding]; other site 378806014198 Mg2+ binding site [ion binding]; other site 378806014199 G-X-G motif; other site 378806014200 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806014201 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806014202 active site 378806014203 metal binding site [ion binding]; metal-binding site 378806014204 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 378806014205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014206 active site 378806014207 phosphorylation site [posttranslational modification] 378806014208 intermolecular recognition site; other site 378806014209 dimerization interface [polypeptide binding]; other site 378806014210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806014211 DNA binding site [nucleotide binding] 378806014212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806014213 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 378806014214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806014215 dimer interface [polypeptide binding]; other site 378806014216 conserved gate region; other site 378806014217 putative PBP binding loops; other site 378806014218 ABC-ATPase subunit interface; other site 378806014219 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 378806014220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806014221 ABC-ATPase subunit interface; other site 378806014222 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 378806014223 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 378806014224 Walker A/P-loop; other site 378806014225 ATP binding site [chemical binding]; other site 378806014226 Q-loop/lid; other site 378806014227 ABC transporter signature motif; other site 378806014228 Walker B; other site 378806014229 D-loop; other site 378806014230 H-loop/switch region; other site 378806014231 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 378806014232 PhoU domain; Region: PhoU; pfam01895 378806014233 PhoU domain; Region: PhoU; pfam01895 378806014234 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 378806014235 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 378806014236 ligand binding site [chemical binding]; other site 378806014237 Response regulator receiver domain; Region: Response_reg; pfam00072 378806014238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014239 active site 378806014240 phosphorylation site [posttranslational modification] 378806014241 intermolecular recognition site; other site 378806014242 dimerization interface [polypeptide binding]; other site 378806014243 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 378806014244 C-term; Region: GreA_GreB; pfam01272 378806014245 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 378806014246 signal recognition particle protein; Provisional; Region: PRK10867 378806014247 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 378806014248 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 378806014249 P loop; other site 378806014250 GTP binding site [chemical binding]; other site 378806014251 Signal peptide binding domain; Region: SRP_SPB; pfam02978 378806014252 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806014253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 378806014254 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 378806014255 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 378806014256 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806014257 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806014258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014259 TPR motif; other site 378806014260 binding surface 378806014261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014262 binding surface 378806014263 TPR motif; other site 378806014264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014265 binding surface 378806014266 TPR motif; other site 378806014267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014268 binding surface 378806014269 TPR motif; other site 378806014270 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806014271 phosphopeptide binding site; other site 378806014272 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806014273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014274 binding surface 378806014275 TPR motif; other site 378806014276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014277 TPR motif; other site 378806014278 binding surface 378806014279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014280 binding surface 378806014281 TPR motif; other site 378806014282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014283 binding surface 378806014284 TPR motif; other site 378806014285 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 378806014286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 378806014287 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 378806014288 hypothetical protein; Validated; Region: PRK08116 378806014289 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806014290 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 378806014291 putative binding surface; other site 378806014292 active site 378806014293 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 378806014294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014295 active site 378806014296 phosphorylation site [posttranslational modification] 378806014297 intermolecular recognition site; other site 378806014298 dimerization interface [polypeptide binding]; other site 378806014299 CheB methylesterase; Region: CheB_methylest; pfam01339 378806014300 Integral membrane protein TerC family; Region: TerC; cl10468 378806014301 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 378806014302 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 378806014303 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 378806014304 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 378806014305 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 378806014306 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 378806014307 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806014308 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 378806014309 NHL repeat; Region: NHL; pfam01436 378806014310 aspartate kinase; Reviewed; Region: PRK06635 378806014311 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli (...; Region: AAK_AK-DapG-like; cd04246 378806014312 putative catalytic residues [active] 378806014313 putative nucleotide binding site [chemical binding]; other site 378806014314 putative aspartate binding site [chemical binding]; other site 378806014315 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 378806014316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806014317 Walker A/P-loop; other site 378806014318 ATP binding site [chemical binding]; other site 378806014319 Q-loop/lid; other site 378806014320 ABC transporter signature motif; other site 378806014321 Walker B; other site 378806014322 D-loop; other site 378806014323 H-loop/switch region; other site 378806014324 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806014325 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 378806014326 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 378806014327 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806014328 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 378806014329 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806014330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806014331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806014332 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 378806014333 CHRD domain; Region: CHRD; cl06473 378806014334 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 378806014335 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 378806014336 active site 378806014337 Ap6A binding site [chemical binding]; other site 378806014338 nudix motif; other site 378806014339 metal binding site [ion binding]; metal-binding site 378806014340 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 378806014341 oligomerisation interface [polypeptide binding]; other site 378806014342 mobile loop; other site 378806014343 roof hairpin; other site 378806014344 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 378806014345 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 378806014346 ring oligomerisation interface [polypeptide binding]; other site 378806014347 ATP/Mg binding site [chemical binding]; other site 378806014348 stacking interactions; other site 378806014349 hinge regions; other site 378806014350 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 378806014351 GSH binding site [chemical binding]; other site 378806014352 catalytic residues [active] 378806014353 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806014354 phosphopeptide binding site; other site 378806014355 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806014356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806014357 Walker A motif; other site 378806014358 ATP binding site [chemical binding]; other site 378806014359 Walker B motif; other site 378806014360 arginine finger; other site 378806014361 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806014362 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 378806014363 Walker A/P-loop; other site 378806014364 ATP binding site [chemical binding]; other site 378806014365 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 378806014366 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 378806014367 Q-loop/lid; other site 378806014368 ABC transporter signature motif; other site 378806014369 Walker B; other site 378806014370 D-loop; other site 378806014371 H-loop/switch region; other site 378806014372 Domain of unknown function DUF21; Region: DUF21; pfam01595 378806014373 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 378806014374 Transporter associated domain; Region: CorC_HlyC; pfam03471 378806014375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014376 binding surface 378806014377 TPR motif; other site 378806014378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014379 binding surface 378806014380 TPR motif; other site 378806014381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014382 binding surface 378806014383 TPR motif; other site 378806014384 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 378806014385 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 378806014386 putative active site [active] 378806014387 putative metal binding site [ion binding]; other site 378806014388 peptide chain release factor 1; Validated; Region: prfA; PRK00591 378806014389 RF-1 domain; Region: RF-1; cl02875 378806014390 RF-1 domain; Region: RF-1; cl02875 378806014391 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 378806014392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806014393 S-adenosylmethionine binding site [chemical binding]; other site 378806014394 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 378806014395 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 378806014396 hinge; other site 378806014397 active site 378806014398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 378806014399 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806014400 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 378806014401 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 378806014402 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 378806014403 active site 378806014404 catalytic residues [active] 378806014405 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 378806014406 dimer interface [polypeptide binding]; other site 378806014407 catalytic triad [active] 378806014408 peroxidatic and resolving cysteines [active] 378806014409 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 378806014410 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806014411 O-methyltransferase; Region: Methyltransf_2; pfam00891 378806014412 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806014413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806014414 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 378806014415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806014416 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 378806014417 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806014418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806014419 catalytic residue [active] 378806014420 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 378806014421 peptide modification radical SAM enzyme, GSU_1560 family; Region: rSAM_for_selen; TIGR04082 378806014422 hypothetical protein; Provisional; Region: PRK05409 378806014423 Protein of unknown function (DUF692); Region: DUF692; cl01263 378806014424 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 378806014425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806014426 non-specific DNA binding site [nucleotide binding]; other site 378806014427 salt bridge; other site 378806014428 sequence-specific DNA binding site [nucleotide binding]; other site 378806014429 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 378806014430 Domain of unknown function (DUF955); Region: DUF955; cl01076 378806014431 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 378806014432 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 378806014433 multifunctional aminopeptidase A; Provisional; Region: PRK00913 378806014434 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 378806014435 interface (dimer of trimers) [polypeptide binding]; other site 378806014436 Substrate-binding/catalytic site; other site 378806014437 Zn-binding sites [ion binding]; other site 378806014438 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 378806014439 active site 378806014440 dimer interface [polypeptide binding]; other site 378806014441 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 378806014442 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806014443 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 378806014444 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 378806014445 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 378806014446 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 378806014447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806014448 Walker A motif; other site 378806014449 ATP binding site [chemical binding]; other site 378806014450 Walker B motif; other site 378806014451 arginine finger; other site 378806014452 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 378806014453 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 378806014454 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 378806014455 NAD(P) binding site [chemical binding]; other site 378806014456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806014457 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806014458 sugar binding site [chemical binding]; other site 378806014459 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 378806014460 metal binding site [ion binding]; metal-binding site 378806014461 ligand binding site [chemical binding]; other site 378806014462 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 378806014463 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 378806014464 MatE; Region: MatE; pfam01554 378806014465 MatE; Region: MatE; pfam01554 378806014466 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 378806014467 Mechanosensitive ion channel; Region: MS_channel; pfam00924 378806014468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806014469 Putative cyclase; Region: Cyclase; cl00814 378806014470 PilZ domain; Region: PilZ; cl01260 378806014471 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 378806014472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806014473 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806014474 putative sugar binding sites [chemical binding]; other site 378806014475 Q-X-W motif; other site 378806014476 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 378806014477 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 378806014478 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 378806014479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 378806014480 active site 378806014481 metal binding site [ion binding]; metal-binding site 378806014482 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 378806014483 thioester formation/cholesterol transfer; other site 378806014484 protein-splicing catalytic site; other site 378806014485 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 378806014486 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 378806014487 thioester formation/cholesterol transfer; other site 378806014488 protein-splicing catalytic site; other site 378806014489 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 378806014490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806014491 NAD(P) binding site [chemical binding]; other site 378806014492 active site 378806014493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806014494 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806014495 Protein kinase domain; Region: Pkinase; pfam00069 378806014496 active site 378806014497 ATP binding site [chemical binding]; other site 378806014498 substrate binding site [chemical binding]; other site 378806014499 activation loop (A-loop); other site 378806014500 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 378806014501 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806014502 active site 378806014503 HIGH motif; other site 378806014504 nucleotide binding site [chemical binding]; other site 378806014505 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806014506 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806014507 active site 378806014508 KMSKS motif; other site 378806014509 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 378806014510 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 378806014511 tRNA binding surface [nucleotide binding]; other site 378806014512 anticodon binding site; other site 378806014513 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 378806014514 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806014515 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806014516 CotH protein; Region: CotH; pfam08757 378806014517 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 378806014518 RuvA N terminal domain; Region: RuvA_N; pfam01330 378806014519 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 378806014520 active site 378806014521 putative DNA-binding cleft [nucleotide binding]; other site 378806014522 dimer interface [polypeptide binding]; other site 378806014523 Domain of unknown function DUF28; Region: DUF28; cl00361 378806014524 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806014525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014526 active site 378806014527 phosphorylation site [posttranslational modification] 378806014528 intermolecular recognition site; other site 378806014529 dimerization interface [polypeptide binding]; other site 378806014530 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 378806014531 putative dimer interface [polypeptide binding]; other site 378806014532 putative active site [active] 378806014533 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 378806014534 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 378806014535 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 378806014536 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 378806014537 Uncharacterized conserved protein [Function unknown]; Region: COG2308 378806014538 Domain of unknown function (DUF404); Region: DUF404; pfam04169 378806014539 Domain of unknown function (DUF407); Region: DUF407; pfam04174 378806014540 Lipoprotein N-terminal Domain; Region: LPD_N; smart00638 378806014541 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 378806014542 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 378806014543 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 378806014544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806014545 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 378806014546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806014547 dimer interface [polypeptide binding]; other site 378806014548 conserved gate region; other site 378806014549 putative PBP binding loops; other site 378806014550 ABC-ATPase subunit interface; other site 378806014551 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 378806014552 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 378806014553 Walker A/P-loop; other site 378806014554 ATP binding site [chemical binding]; other site 378806014555 Q-loop/lid; other site 378806014556 ABC transporter signature motif; other site 378806014557 Walker B; other site 378806014558 D-loop; other site 378806014559 H-loop/switch region; other site 378806014560 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 378806014561 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 378806014562 active site 378806014563 putative substrate binding pocket [chemical binding]; other site 378806014564 Survival protein SurE; Region: SurE; cl00448 378806014565 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 378806014566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806014567 S-adenosylmethionine binding site [chemical binding]; other site 378806014568 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 378806014569 dimerization interface [polypeptide binding]; other site 378806014570 active site 378806014571 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 378806014572 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806014573 putative sugar binding sites [chemical binding]; other site 378806014574 Q-X-W motif; other site 378806014575 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 378806014576 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 378806014577 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 378806014578 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 378806014579 putative active site [active] 378806014580 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 378806014581 hypothetical protein; Reviewed; Region: PRK09588 378806014582 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 378806014583 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 378806014584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806014585 Walker A motif; other site 378806014586 ATP binding site [chemical binding]; other site 378806014587 Walker B motif; other site 378806014588 arginine finger; other site 378806014589 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806014590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014591 active site 378806014592 phosphorylation site [posttranslational modification] 378806014593 intermolecular recognition site; other site 378806014594 dimerization interface [polypeptide binding]; other site 378806014595 two component system sensor kinase SsrA; Provisional; Region: PRK15347 378806014596 Cache domain; Region: Cache_1; pfam02743 378806014597 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806014598 dimerization interface [polypeptide binding]; other site 378806014599 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806014600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806014601 ATP binding site [chemical binding]; other site 378806014602 Mg2+ binding site [ion binding]; other site 378806014603 G-X-G motif; other site 378806014604 Uncharacterized conserved protein [Function unknown]; Region: COG3391 378806014605 Uncharacterized conserved protein [Function unknown]; Region: COG3391 378806014606 DTW domain; Region: DTW; cl01221 378806014607 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 378806014608 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 378806014609 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 378806014610 DsbD alpha interface [polypeptide binding]; other site 378806014611 catalytic residues [active] 378806014612 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 378806014613 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 378806014614 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806014615 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806014616 catalytic residue [active] 378806014617 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 378806014618 trimerization site [polypeptide binding]; other site 378806014619 active site 378806014620 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 378806014621 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 378806014622 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 378806014623 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 378806014624 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 378806014625 Sulfatase; Region: Sulfatase; cl10460 378806014626 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 378806014627 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 378806014628 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 378806014629 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 378806014630 mevalonate kinase; Region: mevalon_kin; TIGR00549 378806014631 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 378806014632 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 378806014633 homodimer interface [polypeptide binding]; other site 378806014634 NAD binding site [chemical binding]; other site 378806014635 catalytic residues [active] 378806014636 substrate binding pocket [chemical binding]; other site 378806014637 flexible flap; other site 378806014638 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 378806014639 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 378806014640 homotetramer interface [polypeptide binding]; other site 378806014641 FMN binding site [chemical binding]; other site 378806014642 homodimer contacts [polypeptide binding]; other site 378806014643 putative active site [active] 378806014644 putative substrate binding site [chemical binding]; other site 378806014645 synthase/transferase; Region: PLN02316 378806014646 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806014647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806014648 dimer interface [polypeptide binding]; other site 378806014649 phosphorylation site [posttranslational modification] 378806014650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806014651 ATP binding site [chemical binding]; other site 378806014652 Mg2+ binding site [ion binding]; other site 378806014653 G-X-G motif; other site 378806014654 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806014655 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806014656 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806014657 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 378806014658 active site 378806014659 Response regulator receiver domain; Region: Response_reg; pfam00072 378806014660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014661 active site 378806014662 phosphorylation site [posttranslational modification] 378806014663 intermolecular recognition site; other site 378806014664 dimerization interface [polypeptide binding]; other site 378806014665 Response regulator receiver domain; Region: Response_reg; pfam00072 378806014666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014667 active site 378806014668 phosphorylation site [posttranslational modification] 378806014669 intermolecular recognition site; other site 378806014670 dimerization interface [polypeptide binding]; other site 378806014671 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806014672 metal binding site [ion binding]; metal-binding site 378806014673 active site 378806014674 I-site; other site 378806014675 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 378806014676 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 378806014677 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 378806014678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806014679 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806014680 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806014681 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806014682 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 378806014683 ATP cone domain; Region: ATP-cone; pfam03477 378806014684 Class I ribonucleotide reductase; Region: RNR_I; cd01679 378806014685 active site 378806014686 dimer interface [polypeptide binding]; other site 378806014687 catalytic residues [active] 378806014688 effector binding site; other site 378806014689 R2 peptide binding site; other site 378806014690 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 378806014691 dimer interface [polypeptide binding]; other site 378806014692 putative radical transfer pathway; other site 378806014693 diiron center [ion binding]; other site 378806014694 tyrosyl radical; other site 378806014695 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806014696 Thymidine kinase; Region: TK; cl00631 378806014697 SpoVG; Region: SpoVG; cl00915 378806014698 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 378806014699 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806014700 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 378806014701 5S rRNA interface [nucleotide binding]; other site 378806014702 CTC domain interface; other site 378806014703 L16 interface [polypeptide binding]; other site 378806014704 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 378806014705 putative active site [active] 378806014706 catalytic residue [active] 378806014707 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 378806014708 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 378806014709 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 378806014710 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 378806014711 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 378806014712 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 378806014713 replicative DNA helicase; Region: DnaB; TIGR00665 378806014714 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 378806014715 Walker A motif; other site 378806014716 ATP binding site [chemical binding]; other site 378806014717 Walker B motif; other site 378806014718 DNA binding loops [nucleotide binding] 378806014719 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 378806014720 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 378806014721 substrate binding site [chemical binding]; other site 378806014722 ATP binding site [chemical binding]; other site 378806014723 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 378806014724 Peptidase C26; Region: Peptidase_C26; pfam07722 378806014725 catalytic triad [active] 378806014726 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 378806014727 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 378806014728 trimer interface [polypeptide binding]; other site 378806014729 active site 378806014730 substrate binding site [chemical binding]; other site 378806014731 CoA binding site [chemical binding]; other site 378806014732 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806014733 phosphopeptide binding site; other site 378806014734 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806014735 Predicted esterase [General function prediction only]; Region: COG0627 378806014736 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 378806014737 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 378806014738 substrate binding site [chemical binding]; other site 378806014739 catalytic Zn binding site [ion binding]; other site 378806014740 NAD binding site [chemical binding]; other site 378806014741 structural Zn binding site [ion binding]; other site 378806014742 dimer interface [polypeptide binding]; other site 378806014743 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 378806014744 Dienelactone hydrolase family; Region: DLH; pfam01738 378806014745 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806014746 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 378806014747 Clp amino terminal domain; Region: Clp_N; pfam02861 378806014748 Clp amino terminal domain; Region: Clp_N; pfam02861 378806014749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806014750 Walker A motif; other site 378806014751 ATP binding site [chemical binding]; other site 378806014752 Walker B motif; other site 378806014753 arginine finger; other site 378806014754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806014755 Walker A motif; other site 378806014756 ATP binding site [chemical binding]; other site 378806014757 Walker B motif; other site 378806014758 arginine finger; other site 378806014759 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378806014760 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 378806014761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806014762 DNA binding residues [nucleotide binding] 378806014763 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806014764 Protein kinase domain; Region: Pkinase; pfam00069 378806014765 active site 378806014766 ATP binding site [chemical binding]; other site 378806014767 substrate binding site [chemical binding]; other site 378806014768 activation loop (A-loop); other site 378806014769 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 378806014770 Arginine repressor [Transcription]; Region: ArgR; COG1438 378806014771 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 378806014772 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 378806014773 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 378806014774 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 378806014775 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 378806014776 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 378806014777 nucleotide binding site [chemical binding]; other site 378806014778 substrate binding site [chemical binding]; other site 378806014779 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 378806014780 M28, and M42; Region: Zinc_peptidase_like; cl14876 378806014781 metal binding site [ion binding]; metal-binding site 378806014782 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 378806014783 active sites [active] 378806014784 Lyase; Region: Lyase_1; pfam00206 378806014785 tetramer interface [polypeptide binding]; other site 378806014786 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 378806014787 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 378806014788 Ligand Binding Site [chemical binding]; other site 378806014789 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 378806014790 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806014791 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 378806014792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806014793 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 378806014794 active site 378806014795 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 378806014796 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 378806014797 dimerization interface 3.5A [polypeptide binding]; other site 378806014798 active site 378806014799 FtsH protease regulator HflC; Provisional; Region: PRK11029 378806014800 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 378806014801 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 378806014802 HflK protein; Region: hflK; TIGR01933 378806014803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806014804 putative substrate translocation pore; other site 378806014805 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 378806014806 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 378806014807 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806014808 active site 378806014809 ATP binding site [chemical binding]; other site 378806014810 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806014811 substrate binding site [chemical binding]; other site 378806014812 activation loop (A-loop); other site 378806014813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806014814 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 378806014815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806014816 active site 378806014817 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 378806014818 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 378806014819 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 378806014820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806014821 dimer interface [polypeptide binding]; other site 378806014822 phosphorylation site [posttranslational modification] 378806014823 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806014824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014825 active site 378806014826 phosphorylation site [posttranslational modification] 378806014827 intermolecular recognition site; other site 378806014828 dimerization interface [polypeptide binding]; other site 378806014829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806014830 Walker A motif; other site 378806014831 ATP binding site [chemical binding]; other site 378806014832 Walker B motif; other site 378806014833 arginine finger; other site 378806014834 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806014835 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 378806014836 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806014837 ligand binding site [chemical binding]; other site 378806014838 flexible hinge region; other site 378806014839 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 378806014840 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 378806014841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806014842 Walker A/P-loop; other site 378806014843 ATP binding site [chemical binding]; other site 378806014844 Q-loop/lid; other site 378806014845 ABC transporter signature motif; other site 378806014846 Walker B; other site 378806014847 D-loop; other site 378806014848 H-loop/switch region; other site 378806014849 CHASE3 domain; Region: CHASE3; cl05000 378806014850 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 378806014851 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806014852 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 378806014853 intersubunit interface [polypeptide binding]; other site 378806014854 active site 378806014855 Zn2+ binding site [ion binding]; other site 378806014856 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 378806014857 Cupin domain; Region: Cupin_2; cl09118 378806014858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806014859 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 378806014860 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 378806014861 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 378806014862 Membrane transport protein; Region: Mem_trans; cl09117 378806014863 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 378806014864 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 378806014865 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 378806014866 putative active site [active] 378806014867 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 378806014868 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 378806014869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014870 active site 378806014871 phosphorylation site [posttranslational modification] 378806014872 intermolecular recognition site; other site 378806014873 dimerization interface [polypeptide binding]; other site 378806014874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806014875 DNA binding site [nucleotide binding] 378806014876 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806014877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806014878 dimer interface [polypeptide binding]; other site 378806014879 phosphorylation site [posttranslational modification] 378806014880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806014881 ATP binding site [chemical binding]; other site 378806014882 Mg2+ binding site [ion binding]; other site 378806014883 G-X-G motif; other site 378806014884 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 378806014885 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 378806014886 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 378806014887 dimer interface [polypeptide binding]; other site 378806014888 active site 378806014889 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 378806014890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806014891 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 378806014892 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 378806014893 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 378806014894 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806014895 substrate binding site [chemical binding]; other site 378806014896 oxyanion hole (OAH) forming residues; other site 378806014897 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 378806014898 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 378806014899 active site 378806014900 Zn binding site [ion binding]; other site 378806014901 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 378806014902 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; cl01910 378806014903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806014904 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 378806014905 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806014906 active site 378806014907 metal binding site [ion binding]; metal-binding site 378806014908 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 378806014909 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 378806014910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806014911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014912 binding surface 378806014913 TPR motif; other site 378806014914 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 378806014915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014916 active site 378806014917 phosphorylation site [posttranslational modification] 378806014918 intermolecular recognition site; other site 378806014919 dimerization interface [polypeptide binding]; other site 378806014920 CheB methylesterase; Region: CheB_methylest; pfam01339 378806014921 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 378806014922 putative binding surface; other site 378806014923 active site 378806014924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806014925 ATP binding site [chemical binding]; other site 378806014926 Mg2+ binding site [ion binding]; other site 378806014927 G-X-G motif; other site 378806014928 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806014929 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806014930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014931 active site 378806014932 phosphorylation site [posttranslational modification] 378806014933 intermolecular recognition site; other site 378806014934 dimerization interface [polypeptide binding]; other site 378806014935 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806014936 dimerization interface [polypeptide binding]; other site 378806014937 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806014938 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806014939 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806014940 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806014941 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806014942 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806014943 ligand binding site [chemical binding]; other site 378806014944 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806014945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806014946 active site 378806014947 phosphorylation site [posttranslational modification] 378806014948 intermolecular recognition site; other site 378806014949 dimerization interface [polypeptide binding]; other site 378806014950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806014951 Walker A motif; other site 378806014952 ATP binding site [chemical binding]; other site 378806014953 Walker B motif; other site 378806014954 arginine finger; other site 378806014955 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806014956 DoxX; Region: DoxX; cl00976 378806014957 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 378806014958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806014959 dimer interface [polypeptide binding]; other site 378806014960 phosphorylation site [posttranslational modification] 378806014961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806014962 ATP binding site [chemical binding]; other site 378806014963 Mg2+ binding site [ion binding]; other site 378806014964 G-X-G motif; other site 378806014965 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806014966 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806014967 calcium binding site 2 [ion binding]; other site 378806014968 active site 378806014969 catalytic triad [active] 378806014970 calcium binding site 1 [ion binding]; other site 378806014971 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806014972 ligand binding site [chemical binding]; other site 378806014973 putative alpha-glucosidase; Provisional; Region: PRK10658 378806014974 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 378806014975 trimer interface [polypeptide binding]; other site 378806014976 active site 378806014977 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 378806014978 catalytic site [active] 378806014979 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 378806014980 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806014981 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 378806014982 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 378806014983 putative phosphate binding site [ion binding]; other site 378806014984 putative catalytic site [active] 378806014985 active site 378806014986 metal binding site A [ion binding]; metal-binding site 378806014987 DNA binding site [nucleotide binding] 378806014988 putative AP binding site [nucleotide binding]; other site 378806014989 putative metal binding site B [ion binding]; other site 378806014990 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806014991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806014992 TPR motif; other site 378806014993 binding surface 378806014994 Transglycosylase; Region: Transgly; cl07896 378806014995 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 378806014996 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 378806014997 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806014998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806014999 dimer interface [polypeptide binding]; other site 378806015000 phosphorylation site [posttranslational modification] 378806015001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806015002 ATP binding site [chemical binding]; other site 378806015003 Mg2+ binding site [ion binding]; other site 378806015004 G-X-G motif; other site 378806015005 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 378806015006 30S subunit binding site; other site 378806015007 Response regulator receiver domain; Region: Response_reg; pfam00072 378806015008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015009 active site 378806015010 phosphorylation site [posttranslational modification] 378806015011 intermolecular recognition site; other site 378806015012 dimerization interface [polypeptide binding]; other site 378806015013 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 378806015014 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 378806015015 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806015016 ligand binding site [chemical binding]; other site 378806015017 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 378806015018 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 378806015019 Permutation of conserved domain; other site 378806015020 active site 378806015021 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 378806015022 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806015023 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 378806015024 active site/substrate binding site [active] 378806015025 tetramer interface [polypeptide binding]; other site 378806015026 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806015027 phosphopeptide binding site; other site 378806015028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806015029 metal binding site [ion binding]; metal-binding site 378806015030 active site 378806015031 I-site; other site 378806015032 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 378806015033 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 378806015034 GatB domain; Region: GatB_Yqey; cl11497 378806015035 DNA primase, catalytic core; Region: dnaG; TIGR01391 378806015036 CHC2 zinc finger; Region: zf-CHC2; cl02597 378806015037 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 378806015038 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 378806015039 active site 378806015040 metal binding site [ion binding]; metal-binding site 378806015041 interdomain interaction site; other site 378806015042 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 378806015043 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 378806015044 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 378806015045 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 378806015046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806015047 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 378806015048 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806015049 DNA binding residues [nucleotide binding] 378806015050 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 378806015051 DNA binding site [nucleotide binding] 378806015052 active site 378806015053 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806015054 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806015055 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015056 active site 378806015057 ATP binding site [chemical binding]; other site 378806015058 substrate binding site [chemical binding]; other site 378806015059 activation loop (A-loop); other site 378806015060 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015061 active site 378806015062 ATP binding site [chemical binding]; other site 378806015063 substrate binding site [chemical binding]; other site 378806015064 activation loop (A-loop); other site 378806015065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806015066 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806015067 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 378806015068 potential frameshift: common BLAST hit: gi|189501225|ref|YP_001960695.1| transposase family protein 378806015069 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 378806015070 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 378806015071 TIR domain; Region: TIR; cl02060 378806015072 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806015073 Domain of unknown function (DUF955); Region: DUF955; cl01076 378806015074 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 378806015075 Phosphotransferase enzyme family; Region: APH; pfam01636 378806015076 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806015077 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 378806015078 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 378806015079 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806015080 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806015081 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806015082 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806015083 Integrase core domain; Region: rve; cl01316 378806015084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 378806015085 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378806015086 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806015087 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806015088 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015089 active site 378806015090 ATP binding site [chemical binding]; other site 378806015091 substrate binding site [chemical binding]; other site 378806015092 activation loop (A-loop); other site 378806015093 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015094 active site 378806015095 ATP binding site [chemical binding]; other site 378806015096 substrate binding site [chemical binding]; other site 378806015097 activation loop (A-loop); other site 378806015098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806015099 translocation protein TolB; Provisional; Region: tolB; PRK05137 378806015100 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 378806015101 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 378806015102 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806015103 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 378806015104 active site clefts [active] 378806015105 zinc binding site [ion binding]; other site 378806015106 dimer interface [polypeptide binding]; other site 378806015107 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 378806015108 Sulfate transporter family; Region: Sulfate_transp; cl00967 378806015109 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806015110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015111 active site 378806015112 phosphorylation site [posttranslational modification] 378806015113 intermolecular recognition site; other site 378806015114 dimerization interface [polypeptide binding]; other site 378806015115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806015116 Walker A motif; other site 378806015117 ATP binding site [chemical binding]; other site 378806015118 Walker B motif; other site 378806015119 arginine finger; other site 378806015120 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806015121 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806015122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806015123 ATP binding site [chemical binding]; other site 378806015124 Mg2+ binding site [ion binding]; other site 378806015125 G-X-G motif; other site 378806015126 Integrase core domain; Region: rve; cl01316 378806015127 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 378806015128 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 378806015129 Allene oxide cyclase; Region: Allene_ox_cyc; cl05704 378806015130 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806015131 active site 378806015132 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 378806015133 conserved cys residue [active] 378806015134 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 378806015135 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 378806015136 conserved cys residue [active] 378806015137 Cellulose binding domain; Region: CBM_3; pfam00942 378806015138 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 378806015139 Transcriptional regulators [Transcription]; Region: PurR; COG1609 378806015140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 378806015141 DNA binding site [nucleotide binding] 378806015142 domain linker motif; other site 378806015143 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 378806015144 ligand binding site [chemical binding]; other site 378806015145 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 378806015146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806015147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806015148 catalytic residue [active] 378806015149 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 378806015150 Cupin domain; Region: Cupin_2; cl09118 378806015151 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 378806015152 DNA-binding site [nucleotide binding]; DNA binding site 378806015153 RNA-binding motif; other site 378806015154 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 378806015155 dimer interface [polypeptide binding]; other site 378806015156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378806015157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015158 active site 378806015159 phosphorylation site [posttranslational modification] 378806015160 intermolecular recognition site; other site 378806015161 dimerization interface [polypeptide binding]; other site 378806015162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806015163 DNA binding site [nucleotide binding] 378806015164 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806015165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806015166 dimer interface [polypeptide binding]; other site 378806015167 phosphorylation site [posttranslational modification] 378806015168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806015169 ATP binding site [chemical binding]; other site 378806015170 Mg2+ binding site [ion binding]; other site 378806015171 G-X-G motif; other site 378806015172 UbiA prenyltransferase family; Region: UbiA; cl00337 378806015173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015174 binding surface 378806015175 TPR motif; other site 378806015176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015177 binding surface 378806015178 TPR motif; other site 378806015179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015180 binding surface 378806015181 TPR motif; other site 378806015182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015183 TPR motif; other site 378806015184 binding surface 378806015185 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 378806015186 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 378806015187 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 378806015188 DNA-K related protein; Region: DUF3731; pfam12531 378806015189 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 378806015190 Phytase; Region: Phytase; pfam02333 378806015191 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 378806015192 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 378806015193 NADP-binding site; other site 378806015194 homotetramer interface [polypeptide binding]; other site 378806015195 substrate binding site [chemical binding]; other site 378806015196 homodimer interface [polypeptide binding]; other site 378806015197 active site 378806015198 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 378806015199 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 378806015200 NADP-binding site; other site 378806015201 homotetramer interface [polypeptide binding]; other site 378806015202 substrate binding site [chemical binding]; other site 378806015203 homodimer interface [polypeptide binding]; other site 378806015204 active site 378806015205 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806015206 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806015207 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806015208 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 378806015209 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 378806015210 active site residue [active] 378806015211 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 378806015212 ATP binding site [chemical binding]; other site 378806015213 substrate interface [chemical binding]; other site 378806015214 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 378806015215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806015216 S-adenosylmethionine binding site [chemical binding]; other site 378806015217 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 378806015218 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like; cd06192 378806015219 FAD binding pocket [chemical binding]; other site 378806015220 FAD binding motif [chemical binding]; other site 378806015221 phosphate binding motif [ion binding]; other site 378806015222 beta-alpha-beta structure motif; other site 378806015223 NAD binding pocket [chemical binding]; other site 378806015224 Iron coordination center [ion binding]; other site 378806015225 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378806015226 catalytic core [active] 378806015227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015228 Response regulator receiver domain; Region: Response_reg; pfam00072 378806015229 active site 378806015230 phosphorylation site [posttranslational modification] 378806015231 intermolecular recognition site; other site 378806015232 dimerization interface [polypeptide binding]; other site 378806015233 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806015234 metal binding site [ion binding]; metal-binding site 378806015235 active site 378806015236 I-site; other site 378806015237 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 378806015238 hinge region; other site 378806015239 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 378806015240 putative nucleotide binding site [chemical binding]; other site 378806015241 uridine monophosphate binding site [chemical binding]; other site 378806015242 homohexameric interface [polypeptide binding]; other site 378806015243 elongation factor Ts; Reviewed; Region: tsf; PRK12332 378806015244 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 378806015245 Elongation factor TS; Region: EF_TS; pfam00889 378806015246 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 378806015247 rRNA interaction site [nucleotide binding]; other site 378806015248 S8 interaction site; other site 378806015249 putative laminin-1 binding site; other site 378806015250 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 378806015251 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 378806015252 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 378806015253 SEC-C motif; Region: SEC-C; cl12132 378806015254 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 378806015255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806015256 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806015257 metal binding site [ion binding]; metal-binding site 378806015258 active site 378806015259 I-site; other site 378806015260 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 378806015261 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806015262 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 378806015263 Active site [active] 378806015264 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 378806015265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806015266 Walker A/P-loop; other site 378806015267 ATP binding site [chemical binding]; other site 378806015268 Q-loop/lid; other site 378806015269 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 378806015270 ABC transporter signature motif; other site 378806015271 Walker B; other site 378806015272 D-loop; other site 378806015273 H-loop/switch region; other site 378806015274 Uncharacterized conserved protein [Function unknown]; Region: COG4715 378806015275 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 378806015276 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 378806015277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806015278 ATP binding site [chemical binding]; other site 378806015279 putative Mg++ binding site [ion binding]; other site 378806015280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806015281 nucleotide binding region [chemical binding]; other site 378806015282 ATP-binding site [chemical binding]; other site 378806015283 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 378806015284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806015285 transcriptional regulator BetI; Validated; Region: PRK00767 378806015286 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 378806015287 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806015288 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 378806015289 threonine synthase; Validated; Region: PRK08197 378806015290 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 378806015291 homodimer interface [polypeptide binding]; other site 378806015292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806015293 catalytic residue [active] 378806015294 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806015295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806015296 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 378806015297 Walker A/P-loop; other site 378806015298 ATP binding site [chemical binding]; other site 378806015299 Q-loop/lid; other site 378806015300 ABC transporter signature motif; other site 378806015301 Walker B; other site 378806015302 D-loop; other site 378806015303 H-loop/switch region; other site 378806015304 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806015305 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 378806015306 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806015307 active site 378806015308 metal binding site [ion binding]; metal-binding site 378806015309 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 378806015310 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 378806015311 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 378806015312 putative active site [active] 378806015313 Protein kinase domain; Region: Pkinase; pfam00069 378806015314 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015315 active site 378806015316 ATP binding site [chemical binding]; other site 378806015317 substrate binding site [chemical binding]; other site 378806015318 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806015319 substrate binding site [chemical binding]; other site 378806015320 activation loop (A-loop); other site 378806015321 activation loop (A-loop); other site 378806015322 PEGA domain; Region: PEGA; pfam08308 378806015323 ATP-NAD kinase; Region: NAD_kinase; pfam01513 378806015324 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 378806015325 recombination factor protein RarA; Reviewed; Region: PRK13342 378806015326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806015327 Walker A motif; other site 378806015328 ATP binding site [chemical binding]; other site 378806015329 Walker B motif; other site 378806015330 arginine finger; other site 378806015331 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 378806015332 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806015333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015334 active site 378806015335 phosphorylation site [posttranslational modification] 378806015336 intermolecular recognition site; other site 378806015337 dimerization interface [polypeptide binding]; other site 378806015338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806015339 Walker A motif; other site 378806015340 ATP binding site [chemical binding]; other site 378806015341 Walker B motif; other site 378806015342 arginine finger; other site 378806015343 Response regulator receiver domain; Region: Response_reg; pfam00072 378806015344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015345 active site 378806015346 phosphorylation site [posttranslational modification] 378806015347 intermolecular recognition site; other site 378806015348 dimerization interface [polypeptide binding]; other site 378806015349 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806015350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806015351 dimer interface [polypeptide binding]; other site 378806015352 phosphorylation site [posttranslational modification] 378806015353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806015354 ATP binding site [chemical binding]; other site 378806015355 G-X-G motif; other site 378806015356 Response regulator receiver domain; Region: Response_reg; pfam00072 378806015357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015358 active site 378806015359 phosphorylation site [posttranslational modification] 378806015360 intermolecular recognition site; other site 378806015361 dimerization interface [polypeptide binding]; other site 378806015362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806015363 metal binding site [ion binding]; metal-binding site 378806015364 active site 378806015365 I-site; other site 378806015366 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 378806015367 Ligand binding site [chemical binding]; other site 378806015368 Putative Catalytic site [active] 378806015369 DXD motif; other site 378806015370 YdjC-like protein; Region: YdjC; cl01344 378806015371 Cache domain; Region: Cache_1; pfam02743 378806015372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806015373 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806015374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806015375 dimer interface [polypeptide binding]; other site 378806015376 phosphorylation site [posttranslational modification] 378806015377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806015378 ATP binding site [chemical binding]; other site 378806015379 Mg2+ binding site [ion binding]; other site 378806015380 G-X-G motif; other site 378806015381 Response regulator receiver domain; Region: Response_reg; pfam00072 378806015382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015383 active site 378806015384 phosphorylation site [posttranslational modification] 378806015385 intermolecular recognition site; other site 378806015386 dimerization interface [polypeptide binding]; other site 378806015387 Response regulator receiver domain; Region: Response_reg; pfam00072 378806015388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015389 active site 378806015390 phosphorylation site [posttranslational modification] 378806015391 intermolecular recognition site; other site 378806015392 dimerization interface [polypeptide binding]; other site 378806015393 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 378806015394 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 378806015395 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 378806015396 ligand binding site [chemical binding]; other site 378806015397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015398 active site 378806015399 phosphorylation site [posttranslational modification] 378806015400 intermolecular recognition site; other site 378806015401 dimerization interface [polypeptide binding]; other site 378806015402 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806015403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806015404 ATP binding site [chemical binding]; other site 378806015405 Mg2+ binding site [ion binding]; other site 378806015406 G-X-G motif; other site 378806015407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806015408 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 378806015409 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806015410 substrate binding site [chemical binding]; other site 378806015411 oxyanion hole (OAH) forming residues; other site 378806015412 trimer interface [polypeptide binding]; other site 378806015413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806015414 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 378806015415 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 378806015416 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 378806015417 dimer interface [polypeptide binding]; other site 378806015418 active site 378806015419 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 378806015420 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 378806015421 substrate binding site [chemical binding]; other site 378806015422 active site 378806015423 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 378806015424 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 378806015425 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806015426 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806015427 Phage integrase family; Region: Phage_integrase; pfam00589 378806015428 DNA binding site [nucleotide binding] 378806015429 Int/Topo IB signature motif; other site 378806015430 active site 378806015431 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378806015432 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 378806015433 tetramer interface [polypeptide binding]; other site 378806015434 active site 378806015435 Mg2+/Mn2+ binding site [ion binding]; other site 378806015436 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806015437 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 378806015438 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806015439 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806015440 3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640 378806015441 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 378806015442 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 378806015443 catalytic residue [active] 378806015444 aspartate kinase; Reviewed; Region: PRK06635 378806015445 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 378806015446 putative nucleotide binding site [chemical binding]; other site 378806015447 putative catalytic residues [active] 378806015448 putative Mg ion binding site [ion binding]; other site 378806015449 putative aspartate binding site [chemical binding]; other site 378806015450 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 378806015451 putative allosteric regulatory site; other site 378806015452 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 378806015453 putative allosteric regulatory residue; other site 378806015454 Multicopper oxidase; Region: Cu-oxidase; cl14658 378806015455 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 378806015456 Multicopper oxidase; Region: Cu-oxidase; cl14658 378806015457 Transferase family; Region: Transferase; cl03601 378806015458 Cytochrome P450; Region: p450; cl12078 378806015459 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 378806015460 Di-iron ligands [ion binding]; other site 378806015461 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 378806015462 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 378806015463 Fatty acid desaturase; Region: FA_desaturase; pfam00487 378806015464 Di-iron ligands [ion binding]; other site 378806015465 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 378806015466 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806015467 peptide synthase; Validated; Region: PRK05691 378806015468 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806015469 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 378806015470 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806015471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806015472 Peptidase M14-like domain of an uncharacterized group of Peptidase M14 Carboxypeptidase (CP) T (CPT)-like proteins. This group belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-...; Region: M14_CPT_like; cd06226 378806015473 putative active site [active] 378806015474 Zn-binding site [ion binding]; other site 378806015475 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 378806015476 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806015477 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806015478 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806015479 Integrase core domain; Region: rve; cl01316 378806015480 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 378806015481 Integrase core domain; Region: rve; cl01316 378806015482 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 378806015483 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 378806015484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806015485 S-adenosylmethionine binding site [chemical binding]; other site 378806015486 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 378806015487 acetoin reductases; Region: 23BDH; TIGR02415 378806015488 NADP binding site [chemical binding]; other site 378806015489 active site 378806015490 steroid binding site; other site 378806015491 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 378806015492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806015493 dimerization interface [polypeptide binding]; other site 378806015494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806015495 nucleotide binding region [chemical binding]; other site 378806015496 ATP-binding site [chemical binding]; other site 378806015497 putative oxidoreductase; Provisional; Region: PRK11579 378806015498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806015499 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 378806015500 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 378806015501 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806015502 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 378806015503 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 378806015504 putative substrate binding site [chemical binding]; other site 378806015505 active site 378806015506 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 378806015507 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 378806015508 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 378806015509 substrate binding site [chemical binding]; other site 378806015510 active site 378806015511 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 378806015512 putative metal binding site [ion binding]; other site 378806015513 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 378806015514 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 378806015515 VanW like protein; Region: VanW; pfam04294 378806015516 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 378806015517 putative dimer interface [polypeptide binding]; other site 378806015518 catalytic triad [active] 378806015519 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806015520 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 378806015521 His-Xaa-Ser repeat-associated downstream radical SAM protein; Region: rSAM_paired_2; TIGR03977 378806015522 His-Xaa-Ser repeat-associated upstream radical SAM protein; Region: rSAM_paired_1; TIGR03978 378806015523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806015524 FeS/SAM binding site; other site 378806015525 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 378806015526 radical SAM pair-associated protein; Region: chp_LLNDYxLRE; TIGR03976 378806015527 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806015528 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 378806015529 putative NAD(P) binding site [chemical binding]; other site 378806015530 active site 378806015531 transcriptional activator TtdR; Provisional; Region: PRK09801 378806015532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806015533 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 378806015534 putative effector binding pocket; other site 378806015535 dimerization interface [polypeptide binding]; other site 378806015536 classical (c) SDRs; Region: SDR_c; cd05233 378806015537 NAD(P) binding site [chemical binding]; other site 378806015538 active site 378806015539 Transcriptional regulators [Transcription]; Region: GntR; COG1802 378806015540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806015541 DNA-binding site [nucleotide binding]; DNA binding site 378806015542 Kelch motif; Region: Kelch_1; cl02701 378806015543 kelch-like protein; Provisional; Region: PHA03098 378806015544 Kelch motif; Region: Kelch_1; cl02701 378806015545 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015546 active site 378806015547 ATP binding site [chemical binding]; other site 378806015548 substrate binding site [chemical binding]; other site 378806015549 activation loop (A-loop); other site 378806015550 Protein kinase domain; Region: Pkinase; pfam00069 378806015551 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015552 active site 378806015553 ATP binding site [chemical binding]; other site 378806015554 substrate binding site [chemical binding]; other site 378806015555 activation loop (A-loop); other site 378806015556 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806015557 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806015558 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806015559 Phage capsid family; Region: Phage_capsid; pfam05065 378806015560 Integrase core domain; Region: rve; cl01316 378806015561 Virulence-associated protein E; Region: VirE; pfam05272 378806015562 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378806015563 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806015564 Phage integrase family; Region: Phage_integrase; pfam00589 378806015565 DNA binding site [nucleotide binding] 378806015566 Int/Topo IB signature motif; other site 378806015567 active site 378806015568 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806015569 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806015570 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806015571 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806015572 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806015573 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806015574 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806015575 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806015576 calcium binding site 2 [ion binding]; other site 378806015577 active site 378806015578 catalytic triad [active] 378806015579 calcium binding site 1 [ion binding]; other site 378806015580 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 378806015581 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 378806015582 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806015583 ligand binding site [chemical binding]; other site 378806015584 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 378806015585 catalytic residues [active] 378806015586 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806015587 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 378806015588 protein binding site [polypeptide binding]; other site 378806015589 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 378806015590 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 378806015591 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 378806015592 ATP binding site [chemical binding]; other site 378806015593 active site 378806015594 substrate binding site [chemical binding]; other site 378806015595 adenylosuccinate lyase; Provisional; Region: PRK07492 378806015596 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 378806015597 tetramer interface [polypeptide binding]; other site 378806015598 active site 378806015599 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015600 active site 378806015601 ATP binding site [chemical binding]; other site 378806015602 substrate binding site [chemical binding]; other site 378806015603 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806015604 activation loop (A-loop); other site 378806015605 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 378806015606 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 378806015607 trimer interface [polypeptide binding]; other site 378806015608 active site 378806015609 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 378806015610 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806015611 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 378806015612 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 378806015613 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 378806015614 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 378806015615 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 378806015616 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 378806015617 putative nucleic acid binding region [nucleotide binding]; other site 378806015618 G-X-X-G motif; other site 378806015619 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 378806015620 RNA binding site [nucleotide binding]; other site 378806015621 domain interface; other site 378806015622 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 378806015623 16S/18S rRNA binding site [nucleotide binding]; other site 378806015624 S13e-L30e interaction site [polypeptide binding]; other site 378806015625 25S rRNA binding site [nucleotide binding]; other site 378806015626 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 378806015627 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 378806015628 RNA binding site [nucleotide binding]; other site 378806015629 active site 378806015630 Ribosome-binding factor A; Region: RBFA; cl00542 378806015631 Protein of unknown function (DUF503); Region: DUF503; cl00669 378806015632 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 378806015633 translation initiation factor IF-2; Region: IF-2; TIGR00487 378806015634 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 378806015635 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 378806015636 G1 box; other site 378806015637 putative GEF interaction site [polypeptide binding]; other site 378806015638 GTP/Mg2+ binding site [chemical binding]; other site 378806015639 Switch I region; other site 378806015640 G2 box; other site 378806015641 G3 box; other site 378806015642 Switch II region; other site 378806015643 G4 box; other site 378806015644 G5 box; other site 378806015645 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 378806015646 Translation-initiation factor 2; Region: IF-2; pfam11987 378806015647 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 378806015648 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 378806015649 putative RNA binding cleft [nucleotide binding]; other site 378806015650 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 378806015651 NusA N-terminal domain; Region: NusA_N; pfam08529 378806015652 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 378806015653 RNA binding site [nucleotide binding]; other site 378806015654 homodimer interface [polypeptide binding]; other site 378806015655 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 378806015656 G-X-X-G motif; other site 378806015657 ribosome maturation protein RimP; Reviewed; Region: PRK00092 378806015658 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 378806015659 Sm1 motif; other site 378806015660 predicted subunit interaction site [polypeptide binding]; other site 378806015661 RNA binding pocket [nucleotide binding]; other site 378806015662 Sm2 motif; other site 378806015663 Predicted amidohydrolase [General function prediction only]; Region: COG0388 378806015664 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 378806015665 putative active site [active] 378806015666 catalytic triad [active] 378806015667 dimer interface [polypeptide binding]; other site 378806015668 FecR protein; Region: FecR; pfam04773 378806015669 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 378806015670 Cache domain; Region: Cache_1; pfam02743 378806015671 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 378806015672 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806015673 dimerization interface [polypeptide binding]; other site 378806015674 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 378806015675 Zn2+ binding site [ion binding]; other site 378806015676 Mg2+ binding site [ion binding]; other site 378806015677 Protein of unknown function (DUF971); Region: DUF971; cl01414 378806015678 Protein kinase; unclassified specificity; Region: STYKc; smart00221 378806015679 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015680 active site 378806015681 ATP binding site [chemical binding]; other site 378806015682 substrate binding site [chemical binding]; other site 378806015683 activation loop (A-loop); other site 378806015684 PEGA domain; Region: PEGA; pfam08308 378806015685 Stringent starvation protein B; Region: SspB; cl01120 378806015686 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 378806015687 SmpB-tmRNA interface; other site 378806015688 Pantoate-beta-alanine ligase; Region: PanC; cd00560 378806015689 pantoate--beta-alanine ligase; Region: panC; TIGR00018 378806015690 active site 378806015691 ATP-binding site [chemical binding]; other site 378806015692 pantoate-binding site; other site 378806015693 HXXH motif; other site 378806015694 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 378806015695 oligomerization interface [polypeptide binding]; other site 378806015696 active site 378806015697 metal binding site [ion binding]; metal-binding site 378806015698 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 378806015699 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 378806015700 Substrate-binding site [chemical binding]; other site 378806015701 Substrate specificity [chemical binding]; other site 378806015702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806015703 UGMP family protein; Validated; Region: PRK09604 378806015704 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 378806015705 Response regulator receiver domain; Region: Response_reg; pfam00072 378806015706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015707 active site 378806015708 phosphorylation site [posttranslational modification] 378806015709 intermolecular recognition site; other site 378806015710 dimerization interface [polypeptide binding]; other site 378806015711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015712 binding surface 378806015713 TPR motif; other site 378806015714 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 378806015715 HSP70 interaction site [polypeptide binding]; other site 378806015716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015717 binding surface 378806015718 TPR motif; other site 378806015719 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 378806015720 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 378806015721 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 378806015722 Protein phosphatase 2C; Region: PP2C; pfam00481 378806015723 Active site [active] 378806015724 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 378806015725 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 378806015726 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 378806015727 Substrate binding site [chemical binding]; other site 378806015728 metal binding site [ion binding]; metal-binding site 378806015729 Phosphotransferase enzyme family; Region: APH; pfam01636 378806015730 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 378806015731 active site 378806015732 ATP binding site [chemical binding]; other site 378806015733 substrate binding site [chemical binding]; other site 378806015734 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 378806015735 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 378806015736 dimer interface [polypeptide binding]; other site 378806015737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806015738 catalytic residue [active] 378806015739 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 378806015740 Protein kinase domain; Region: Pkinase; pfam00069 378806015741 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015742 active site 378806015743 ATP binding site [chemical binding]; other site 378806015744 substrate binding site [chemical binding]; other site 378806015745 activation loop (A-loop); other site 378806015746 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 378806015747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806015748 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 378806015749 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 378806015750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806015751 S-adenosylmethionine binding site [chemical binding]; other site 378806015752 Glycerate kinase family; Region: Gly_kinase; cl00841 378806015753 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 378806015754 catalytic triad [active] 378806015755 conserved cis-peptide bond; other site 378806015756 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 378806015757 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019 378806015758 active site 378806015759 Cellulose binding domain; Region: CBM_2; cl02709 378806015760 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 378806015761 Interdomain contacts; other site 378806015762 Cytokine receptor motif; other site 378806015763 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 378806015764 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 378806015765 active site 378806015766 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 378806015767 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 378806015768 dimer interface [polypeptide binding]; other site 378806015769 substrate binding site [chemical binding]; other site 378806015770 metal binding sites [ion binding]; metal-binding site 378806015771 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 378806015772 lysyl-tRNA synthetase-like protein GenX; Region: genX; TIGR00462 378806015773 motif 1; other site 378806015774 dimer interface [polypeptide binding]; other site 378806015775 active site 378806015776 motif 2; other site 378806015777 motif 3; other site 378806015778 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806015779 Zn binding site [ion binding]; other site 378806015780 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 378806015781 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806015782 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806015783 calcium binding site 2 [ion binding]; other site 378806015784 active site 378806015785 catalytic triad [active] 378806015786 calcium binding site 1 [ion binding]; other site 378806015787 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 378806015788 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806015789 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378806015790 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 378806015791 Walker A/P-loop; other site 378806015792 ATP binding site [chemical binding]; other site 378806015793 Q-loop/lid; other site 378806015794 ABC transporter signature motif; other site 378806015795 Walker B; other site 378806015796 D-loop; other site 378806015797 H-loop/switch region; other site 378806015798 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 378806015799 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 378806015800 Rhomboid family; Region: Rhomboid; cl11446 378806015801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015802 TPR motif; other site 378806015803 binding surface 378806015804 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806015805 phosphopeptide binding site; other site 378806015806 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806015807 phosphopeptide binding site; other site 378806015808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015809 binding surface 378806015810 TPR motif; other site 378806015811 Response regulator receiver domain; Region: Response_reg; pfam00072 378806015812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015813 active site 378806015814 phosphorylation site [posttranslational modification] 378806015815 intermolecular recognition site; other site 378806015816 dimerization interface [polypeptide binding]; other site 378806015817 enoyl-CoA hydratase; Provisional; Region: PRK08252 378806015818 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806015819 substrate binding site [chemical binding]; other site 378806015820 oxyanion hole (OAH) forming residues; other site 378806015821 trimer interface [polypeptide binding]; other site 378806015822 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 378806015823 carboxyltransferase (CT) interaction site; other site 378806015824 biotinylation site [posttranslational modification]; other site 378806015825 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 378806015826 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378806015827 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806015828 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 378806015829 cell division protein FtsZ; Validated; Region: PRK09330 378806015830 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 378806015831 nucleotide binding site [chemical binding]; other site 378806015832 SulA interaction site; other site 378806015833 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806015834 ligand binding site [chemical binding]; other site 378806015835 cell division protein FtsA; Region: ftsA; TIGR01174 378806015836 Cell division protein FtsA; Region: FtsA; cl11496 378806015837 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 378806015838 ATP binding site [chemical binding]; other site 378806015839 profilin binding site; other site 378806015840 gelsolin binding site; other site 378806015841 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 378806015842 Cell division protein FtsQ; Region: FtsQ; pfam03799 378806015843 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 378806015844 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 378806015845 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806015846 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652 378806015847 FAD binding domain; Region: FAD_binding_4; pfam01565 378806015848 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 378806015849 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 378806015850 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 378806015851 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378806015852 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378806015853 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 378806015854 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 378806015855 active site 378806015856 homodimer interface [polypeptide binding]; other site 378806015857 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 378806015858 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 378806015859 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 378806015860 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378806015861 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378806015862 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 378806015863 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 378806015864 Mg++ binding site [ion binding]; other site 378806015865 putative catalytic motif [active] 378806015866 putative substrate binding site [chemical binding]; other site 378806015867 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 378806015868 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 378806015869 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378806015870 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378806015871 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 378806015872 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 378806015873 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378806015874 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378806015875 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 378806015876 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 378806015877 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 378806015878 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 378806015879 Septum formation initiator; Region: DivIC; cl11433 378806015880 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 378806015881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806015882 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 378806015883 anti sigma factor interaction site; other site 378806015884 regulatory phosphorylation site [posttranslational modification]; other site 378806015885 MraZ protein; Region: MraZ; pfam02381 378806015886 MraZ protein; Region: MraZ; pfam02381 378806015887 PilZ domain; Region: PilZ; cl01260 378806015888 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl02012 378806015889 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 378806015890 Peptidase family M54; Region: Peptidase_M54; cl00835 378806015891 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 378806015892 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 378806015893 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 378806015894 oligomerization interface [polypeptide binding]; other site 378806015895 active site 378806015896 NAD+ binding site [chemical binding]; other site 378806015897 Deuterolysin metalloprotease (M35) family; Region: Peptidase_M35; pfam02102 378806015898 Deuterolysin metalloprotease (M35) family; Region: Peptidase_M35; pfam02102 378806015899 Gryzun, putative trafficking through Golgi; Region: Gryzun; pfam07919 378806015900 Protein kinase domain; Region: Pkinase; pfam00069 378806015901 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806015902 active site 378806015903 ATP binding site [chemical binding]; other site 378806015904 substrate binding site [chemical binding]; other site 378806015905 activation loop (A-loop); other site 378806015906 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 378806015907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378806015908 dimerization interface [polypeptide binding]; other site 378806015909 putative DNA binding site [nucleotide binding]; other site 378806015910 putative Zn2+ binding site [ion binding]; other site 378806015911 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 378806015912 putative hydrophobic ligand binding site [chemical binding]; other site 378806015913 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 378806015914 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 378806015915 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 378806015916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806015917 FeS/SAM binding site; other site 378806015918 coproporphyrinogen III oxidase; Validated; Region: PRK08208 378806015919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806015920 HemN C-terminal region; Region: HemN_C; pfam06969 378806015921 Sulfatase; Region: Sulfatase; cl10460 378806015922 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 378806015923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806015924 motif II; other site 378806015925 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806015926 cleavage site 378806015927 active site 378806015928 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 378806015929 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 378806015930 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 378806015931 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 378806015932 conserved cys residue [active] 378806015933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806015934 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 378806015935 catalytic triad [active] 378806015936 conserved cis-peptide bond; other site 378806015937 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 378806015938 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 378806015939 putative active site [active] 378806015940 metal binding site [ion binding]; metal-binding site 378806015941 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 378806015942 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 378806015943 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 378806015944 catalytic triad [active] 378806015945 Domain of unknown function DUF20; Region: UPF0118; cl00465 378806015946 transcription termination factor Rho; Provisional; Region: rho; PRK09376 378806015947 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 378806015948 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 378806015949 RNA binding site [nucleotide binding]; other site 378806015950 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 378806015951 multimer interface [polypeptide binding]; other site 378806015952 Walker A motif; other site 378806015953 ATP binding site [chemical binding]; other site 378806015954 Walker B motif; other site 378806015955 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 378806015956 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 378806015957 nucleotide binding pocket [chemical binding]; other site 378806015958 K-X-D-G motif; other site 378806015959 catalytic site [active] 378806015960 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 378806015961 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 378806015962 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 378806015963 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 378806015964 Dimer interface [polypeptide binding]; other site 378806015965 BRCT sequence motif; other site 378806015966 Acylphosphatase; Region: Acylphosphatase; cl00551 378806015967 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 378806015968 RNA binding site [nucleotide binding]; other site 378806015969 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 378806015970 ribonuclease G; Provisional; Region: PRK11712 378806015971 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 378806015972 Predicted transcriptional regulator [Transcription]; Region: COG1959 378806015973 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 378806015974 IHF dimer interface [polypeptide binding]; other site 378806015975 IHF - DNA interface [nucleotide binding]; other site 378806015976 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 378806015977 FHIPEP family; Region: FHIPEP; pfam00771 378806015978 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 378806015979 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 378806015980 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 378806015981 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 378806015982 FliP family; Region: FliP; cl00593 378806015983 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 378806015984 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 378806015985 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 378806015986 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 378806015987 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 378806015988 PilZ domain; Region: PilZ; cl01260 378806015989 Response regulator receiver domain; Region: Response_reg; pfam00072 378806015990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806015991 active site 378806015992 phosphorylation site [posttranslational modification] 378806015993 intermolecular recognition site; other site 378806015994 dimerization interface [polypeptide binding]; other site 378806015995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015996 binding surface 378806015997 TPR motif; other site 378806015998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806015999 TPR motif; other site 378806016000 binding surface 378806016001 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806016002 metal ion-dependent adhesion site (MIDAS); other site 378806016003 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 378806016004 metal ion-dependent adhesion site (MIDAS); other site 378806016005 Protein of unknown function DUF58; Region: DUF58; pfam01882 378806016006 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806016007 MoxR-like ATPases [General function prediction only]; Region: COG0714 378806016008 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806016009 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806016010 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806016011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806016012 S-adenosylmethionine binding site [chemical binding]; other site 378806016013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806016014 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806016015 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 378806016016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 378806016017 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 378806016018 Mechanosensitive ion channel; Region: MS_channel; pfam00924 378806016019 Response regulator receiver domain; Region: Response_reg; pfam00072 378806016020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016021 active site 378806016022 phosphorylation site [posttranslational modification] 378806016023 intermolecular recognition site; other site 378806016024 dimerization interface [polypeptide binding]; other site 378806016025 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806016026 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806016027 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 378806016028 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 378806016029 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378806016030 catalytic residue [active] 378806016031 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806016032 putative peptidoglycan binding site; other site 378806016033 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 378806016034 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806016035 putative peptidoglycan binding site; other site 378806016036 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806016037 putative peptidoglycan binding site; other site 378806016038 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 378806016039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806016040 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806016041 active site 378806016042 ATP binding site [chemical binding]; other site 378806016043 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806016044 substrate binding site [chemical binding]; other site 378806016045 activation loop (A-loop); other site 378806016046 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 378806016047 FtsX-like permease family; Region: FtsX; pfam02687 378806016048 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378806016049 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 378806016050 Walker A/P-loop; other site 378806016051 ATP binding site [chemical binding]; other site 378806016052 Q-loop/lid; other site 378806016053 ABC transporter signature motif; other site 378806016054 Walker B; other site 378806016055 D-loop; other site 378806016056 H-loop/switch region; other site 378806016057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806016058 PspA/IM30 family; Region: PspA_IM30; pfam04012 378806016059 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 378806016060 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 378806016061 active site 378806016062 putative substrate binding pocket [chemical binding]; other site 378806016063 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 378806016064 active site 378806016065 catalytic motif [active] 378806016066 Zn binding site [ion binding]; other site 378806016067 PilZ domain; Region: PilZ; cl01260 378806016068 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 378806016069 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 378806016070 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 378806016071 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 378806016072 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 378806016073 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 378806016074 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 378806016075 ligand binding site [chemical binding]; other site 378806016076 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 378806016077 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 378806016078 Walker A/P-loop; other site 378806016079 ATP binding site [chemical binding]; other site 378806016080 Q-loop/lid; other site 378806016081 ABC transporter signature motif; other site 378806016082 Walker B; other site 378806016083 D-loop; other site 378806016084 H-loop/switch region; other site 378806016085 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 378806016086 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 378806016087 TM-ABC transporter signature motif; other site 378806016088 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 378806016089 TM-ABC transporter signature motif; other site 378806016090 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 378806016091 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 378806016092 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 378806016093 active site 378806016094 substrate binding site [chemical binding]; other site 378806016095 metal binding site [ion binding]; metal-binding site 378806016096 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 378806016097 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 378806016098 intersubunit interface [polypeptide binding]; other site 378806016099 active site 378806016100 catalytic residue [active] 378806016101 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806016102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806016103 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 378806016104 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 378806016105 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 378806016106 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 378806016107 Putative zinc ribbon domain; Region: DUF164; pfam02591 378806016108 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 378806016109 RNA/DNA hybrid binding site [nucleotide binding]; other site 378806016110 active site 378806016111 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 378806016112 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 378806016113 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 378806016114 GTP binding site [chemical binding]; other site 378806016115 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806016116 Zn binding site [ion binding]; other site 378806016117 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806016118 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 378806016119 active site 378806016120 catalytic site [active] 378806016121 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 378806016122 ligand binding surface [chemical binding]; other site 378806016123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806016124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806016125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806016126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806016127 NAD(P) binding site [chemical binding]; other site 378806016128 active site 378806016129 enoyl-CoA hydratase; Region: PLN02864 378806016130 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 378806016131 active site 2 [active] 378806016132 active site 1 [active] 378806016133 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378806016134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806016135 Acyltransferase family; Region: Acyl_transf_3; pfam01757 378806016136 OpgC protein; Region: OpgC_C; cl10497 378806016137 PEGA domain; Region: PEGA; pfam08308 378806016138 PEGA domain; Region: PEGA; pfam08308 378806016139 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 378806016140 DXD motif; other site 378806016141 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 378806016142 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 378806016143 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806016144 PEGA domain; Region: PEGA; pfam08308 378806016145 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 378806016146 C-terminal peptidase (prc); Region: prc; TIGR00225 378806016147 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 378806016148 protein binding site [polypeptide binding]; other site 378806016149 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 378806016150 Catalytic dyad [active] 378806016151 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806016152 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806016153 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 378806016154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806016155 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 378806016156 Walker A/P-loop; other site 378806016157 ATP binding site [chemical binding]; other site 378806016158 Q-loop/lid; other site 378806016159 ABC transporter signature motif; other site 378806016160 Walker B; other site 378806016161 D-loop; other site 378806016162 H-loop/switch region; other site 378806016163 photoactive yellow protein; Region: photo_yellow; TIGR02373 378806016164 Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520 378806016165 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 378806016166 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 378806016167 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 378806016168 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806016169 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806016170 TolB amino-terminal domain; Region: TolB_N; pfam04052 378806016171 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 378806016172 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806016173 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806016174 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806016175 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 378806016176 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806016177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806016178 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806016179 catalytic residue [active] 378806016180 exopolyphosphatase; Region: exo_poly_only; TIGR03706 378806016181 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 378806016182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806016183 D-galactonate transporter; Region: 2A0114; TIGR00893 378806016184 putative substrate translocation pore; other site 378806016185 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 378806016186 active site 378806016187 catalytic triad [active] 378806016188 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 378806016189 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 378806016190 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; cl10556 378806016191 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 378806016192 putative acyl-acceptor binding pocket; other site 378806016193 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 378806016194 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806016195 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 378806016196 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806016197 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806016198 Surface antigen; Region: Bac_surface_Ag; cl03097 378806016199 Family of unknown function (DUF490); Region: DUF490; pfam04357 378806016200 Family of unknown function (DUF490); Region: DUF490; pfam04357 378806016201 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 378806016202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806016203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806016204 binding surface 378806016205 TPR motif; other site 378806016206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806016207 TPR motif; other site 378806016208 binding surface 378806016209 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 378806016210 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378806016211 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806016212 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 378806016213 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 378806016214 carboxyltransferase (CT) interaction site; other site 378806016215 biotinylation site [posttranslational modification]; other site 378806016216 elongation factor P; Validated; Region: PRK00529 378806016217 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 378806016218 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 378806016219 RNA binding site [nucleotide binding]; other site 378806016220 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 378806016221 RNA binding site [nucleotide binding]; other site 378806016222 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 378806016223 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 378806016224 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 378806016225 Secretin and TonB N terminus short domain; Region: STN; pfam07660 378806016226 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 378806016227 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 378806016228 Pilus assembly protein, PilP; Region: PilP; cl01235 378806016229 Pilus assembly protein, PilO; Region: PilO; cl01234 378806016230 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 378806016231 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 378806016232 Competence protein A; Region: Competence_A; pfam11104 378806016233 Cell division protein FtsA; Region: FtsA; cl11496 378806016234 Cell division protein FtsA; Region: FtsA; cl11496 378806016235 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806016236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016237 active site 378806016238 phosphorylation site [posttranslational modification] 378806016239 intermolecular recognition site; other site 378806016240 dimerization interface [polypeptide binding]; other site 378806016241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806016242 Walker A motif; other site 378806016243 ATP binding site [chemical binding]; other site 378806016244 Walker B motif; other site 378806016245 arginine finger; other site 378806016246 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806016247 sensor kinase CusS; Provisional; Region: PRK09835 378806016248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806016249 dimer interface [polypeptide binding]; other site 378806016250 phosphorylation site [posttranslational modification] 378806016251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806016252 ATP binding site [chemical binding]; other site 378806016253 Mg2+ binding site [ion binding]; other site 378806016254 G-X-G motif; other site 378806016255 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 378806016256 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 378806016257 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378806016258 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 378806016259 Walker A/P-loop; other site 378806016260 ATP binding site [chemical binding]; other site 378806016261 Q-loop/lid; other site 378806016262 ABC transporter signature motif; other site 378806016263 Walker B; other site 378806016264 D-loop; other site 378806016265 H-loop/switch region; other site 378806016266 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806016267 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806016268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016269 active site 378806016270 phosphorylation site [posttranslational modification] 378806016271 intermolecular recognition site; other site 378806016272 dimerization interface [polypeptide binding]; other site 378806016273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806016274 Walker A motif; other site 378806016275 ATP binding site [chemical binding]; other site 378806016276 Walker B motif; other site 378806016277 arginine finger; other site 378806016278 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806016279 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806016280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806016281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806016282 phosphorylation site [posttranslational modification] 378806016283 dimer interface [polypeptide binding]; other site 378806016284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806016285 ATP binding site [chemical binding]; other site 378806016286 G-X-G motif; other site 378806016287 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 378806016288 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 378806016289 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 378806016290 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 378806016291 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 378806016292 Walker A motif; other site 378806016293 ATP binding site [chemical binding]; other site 378806016294 Walker B motif; other site 378806016295 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 378806016296 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806016297 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 378806016298 Walker A motif; other site 378806016299 ATP binding site [chemical binding]; other site 378806016300 Walker B motif; other site 378806016301 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 378806016302 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 378806016303 active site 378806016304 Riboflavin kinase; Region: Flavokinase; pfam01687 378806016305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806016306 Response regulator receiver domain; Region: Response_reg; pfam00072 378806016307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016308 active site 378806016309 phosphorylation site [posttranslational modification] 378806016310 intermolecular recognition site; other site 378806016311 dimerization interface [polypeptide binding]; other site 378806016312 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806016313 metal binding site [ion binding]; metal-binding site 378806016314 active site 378806016315 I-site; other site 378806016316 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 378806016317 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 378806016318 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 378806016319 active site 378806016320 substrate binding site [chemical binding]; other site 378806016321 catalytic site [active] 378806016322 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 378806016323 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 378806016324 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 378806016325 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 378806016326 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 378806016327 motif 1; other site 378806016328 active site 378806016329 motif 2; other site 378806016330 motif 3; other site 378806016331 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 378806016332 PilZ domain; Region: PilZ; cl01260 378806016333 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 378806016334 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 378806016335 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 378806016336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806016337 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 378806016338 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 378806016339 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 378806016340 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 378806016341 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 378806016342 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 378806016343 protein binding site [polypeptide binding]; other site 378806016344 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 378806016345 Catalytic dyad [active] 378806016346 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 378806016347 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 378806016348 active site 378806016349 catalytic site [active] 378806016350 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 378806016351 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 378806016352 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 378806016353 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 378806016354 P-loop; other site 378806016355 Magnesium ion binding site [ion binding]; other site 378806016356 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 378806016357 Magnesium ion binding site [ion binding]; other site 378806016358 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806016359 dimerization interface [polypeptide binding]; other site 378806016360 Metal binding site [ion binding]; metal-binding site 378806016361 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 378806016362 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 378806016363 P loop; other site 378806016364 Nucleotide binding site [chemical binding]; other site 378806016365 DTAP/Switch II; other site 378806016366 Switch I; other site 378806016367 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 378806016368 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 378806016369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 378806016370 Peptidase family M48; Region: Peptidase_M48; cl12018 378806016371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806016372 binding surface 378806016373 TPR motif; other site 378806016374 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 378806016375 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806016376 structural tetrad; other site 378806016377 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 378806016378 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 378806016379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806016380 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 378806016381 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806016382 Protein of unknown function (DUF444); Region: DUF444; pfam04285 378806016383 SpoVR like protein; Region: SpoVR; pfam04293 378806016384 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 378806016385 putative peptidase; Provisional; Region: PRK11649 378806016386 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806016387 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806016388 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 378806016389 homodimer interface [polypeptide binding]; other site 378806016390 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 378806016391 active site pocket [active] 378806016392 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 378806016393 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 378806016394 active site 378806016395 Zn binding site [ion binding]; other site 378806016396 short chain dehydrogenase; Provisional; Region: PRK07576 378806016397 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 378806016398 NAD(P) binding site [chemical binding]; other site 378806016399 substrate binding site [chemical binding]; other site 378806016400 homotetramer interface [polypeptide binding]; other site 378806016401 active site 378806016402 homodimer interface [polypeptide binding]; other site 378806016403 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 378806016404 dimer interface [polypeptide binding]; other site 378806016405 substrate binding site [chemical binding]; other site 378806016406 metal binding site [ion binding]; metal-binding site 378806016407 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 378806016408 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 378806016409 Cu(I) binding site [ion binding]; other site 378806016410 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 378806016411 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 378806016412 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 378806016413 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 378806016414 generic binding surface II; other site 378806016415 generic binding surface I; other site 378806016416 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 378806016417 Sulfatase; Region: Sulfatase; cl10460 378806016418 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 378806016419 dimer interface [polypeptide binding]; other site 378806016420 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 378806016421 active site 378806016422 Zn-binding site [ion binding]; other site 378806016423 LysE type translocator; Region: LysE; cl00565 378806016424 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 378806016425 iron-sulfur cluster [ion binding]; other site 378806016426 [2Fe-2S] cluster binding site [ion binding]; other site 378806016427 Cupin domain; Region: Cupin_2; cl09118 378806016428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806016429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806016430 putative transposase OrfB; Reviewed; Region: PHA02517 378806016431 Integrase core domain; Region: rve; cl01316 378806016432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806016433 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 378806016434 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 378806016435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806016436 NAD(P) binding site [chemical binding]; other site 378806016437 active site 378806016438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806016439 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 378806016440 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 378806016441 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806016442 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806016443 Walker A motif; other site 378806016444 ATP binding site [chemical binding]; other site 378806016445 Walker B motif; other site 378806016446 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 378806016447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806016448 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 378806016449 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806016450 hypothetical protein; Provisional; Region: PRK08204 378806016451 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806016452 active site 378806016453 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 378806016454 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 378806016455 Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248 378806016456 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 378806016457 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 378806016458 active site 378806016459 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 378806016460 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 378806016461 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806016462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806016463 helicase 45; Provisional; Region: PTZ00424 378806016464 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 378806016465 ATP binding site [chemical binding]; other site 378806016466 Mg++ binding site [ion binding]; other site 378806016467 motif III; other site 378806016468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806016469 nucleotide binding region [chemical binding]; other site 378806016470 ATP-binding site [chemical binding]; other site 378806016471 DbpA RNA binding domain; Region: DbpA; pfam03880 378806016472 glutamate dehydrogenase; Region: PLN02477 378806016473 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 378806016474 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 378806016475 NAD(P) binding site [chemical binding]; other site 378806016476 threonine dehydratase; Provisional; Region: PRK08198 378806016477 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 378806016478 tetramer interface [polypeptide binding]; other site 378806016479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806016480 catalytic residue [active] 378806016481 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 378806016482 YceI-like domain; Region: YceI; cl01001 378806016483 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 378806016484 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 378806016485 putative active site [active] 378806016486 metal binding site [ion binding]; metal-binding site 378806016487 Activator of aromatic catabolism; Region: XylR_N; pfam06505 378806016488 V4R domain; Region: V4R; cl08369 378806016489 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806016490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806016491 Walker A motif; other site 378806016492 ATP binding site [chemical binding]; other site 378806016493 Walker B motif; other site 378806016494 arginine finger; other site 378806016495 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806016496 putative acyltransferase; Provisional; Region: PRK05790 378806016497 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 378806016498 dimer interface [polypeptide binding]; other site 378806016499 active site 378806016500 Protein kinase domain; Region: Pkinase; pfam00069 378806016501 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806016502 active site 378806016503 ATP binding site [chemical binding]; other site 378806016504 substrate binding site [chemical binding]; other site 378806016505 activation loop (A-loop); other site 378806016506 Predicted ATPase [General function prediction only]; Region: COG3899 378806016507 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806016508 active site 378806016509 substrate binding sites [chemical binding]; other site 378806016510 Response regulator receiver domain; Region: Response_reg; pfam00072 378806016511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016512 active site 378806016513 phosphorylation site [posttranslational modification] 378806016514 intermolecular recognition site; other site 378806016515 dimerization interface [polypeptide binding]; other site 378806016516 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 378806016517 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806016518 Glutamate binding site [chemical binding]; other site 378806016519 NAD binding site [chemical binding]; other site 378806016520 catalytic residues [active] 378806016521 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 378806016522 active site 378806016523 catalytic residues [active] 378806016524 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 378806016525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806016526 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 378806016527 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 378806016528 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 378806016529 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 378806016530 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806016531 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806016532 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806016533 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806016534 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 378806016535 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 378806016536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016537 active site 378806016538 phosphorylation site [posttranslational modification] 378806016539 intermolecular recognition site; other site 378806016540 dimerization interface [polypeptide binding]; other site 378806016541 GAF domain; Region: GAF; cl00853 378806016542 GAF domain; Region: GAF; cl00853 378806016543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806016544 dimer interface [polypeptide binding]; other site 378806016545 phosphorylation site [posttranslational modification] 378806016546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806016547 ATP binding site [chemical binding]; other site 378806016548 Mg2+ binding site [ion binding]; other site 378806016549 G-X-G motif; other site 378806016550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806016551 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806016552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806016553 DNA-binding site [nucleotide binding]; DNA binding site 378806016554 EBNA-3B; Provisional; Region: PHA03378 378806016555 Flavin Reductases; Region: FlaRed; cl00801 378806016556 Protein kinase domain; Region: Pkinase; pfam00069 378806016557 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806016558 active site 378806016559 ATP binding site [chemical binding]; other site 378806016560 substrate binding site [chemical binding]; other site 378806016561 activation loop (A-loop); other site 378806016562 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 378806016563 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 378806016564 putative NAD(P) binding site [chemical binding]; other site 378806016565 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 378806016566 Transglycosylase; Region: Transgly; cl07896 378806016567 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 378806016568 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 378806016569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 378806016570 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806016571 active site 378806016572 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 378806016573 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 378806016574 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 378806016575 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806016576 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806016577 EamA-like transporter family; Region: EamA; cl01037 378806016578 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 378806016579 EamA-like transporter family; Region: EamA; cl01037 378806016580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806016581 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806016582 Walker A/P-loop; other site 378806016583 ATP binding site [chemical binding]; other site 378806016584 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 378806016585 Cytochrome oxidase complex assembly protein 1; Region: Coa1; cl14904 378806016586 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 378806016587 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 378806016588 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 378806016589 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 378806016590 Ligand binding site [chemical binding]; other site 378806016591 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806016592 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806016593 active site 378806016594 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 378806016595 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 378806016596 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 378806016597 active site 378806016598 intersubunit interactions; other site 378806016599 catalytic residue [active] 378806016600 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 378806016601 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 378806016602 putative active site [active] 378806016603 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 378806016604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806016605 binding surface 378806016606 TPR motif; other site 378806016607 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 378806016608 catalytic center binding site [active] 378806016609 ATP binding site [chemical binding]; other site 378806016610 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 378806016611 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 378806016612 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 378806016613 dihydrodipicolinate reductase; Provisional; Region: PRK00048 378806016614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806016615 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 378806016616 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 378806016617 dihydrodipicolinate synthase; Region: dapA; TIGR00674 378806016618 dimer interface [polypeptide binding]; other site 378806016619 active site 378806016620 catalytic residue [active] 378806016621 diaminopimelate decarboxylase; Region: lysA; TIGR01048 378806016622 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 378806016623 active site 378806016624 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 378806016625 substrate binding site [chemical binding]; other site 378806016626 catalytic residues [active] 378806016627 dimer interface [polypeptide binding]; other site 378806016628 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 378806016629 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 378806016630 DNA binding site [nucleotide binding] 378806016631 catalytic residue [active] 378806016632 H2TH interface [polypeptide binding]; other site 378806016633 putative catalytic residues [active] 378806016634 turnover-facilitating residue; other site 378806016635 intercalation triad [nucleotide binding]; other site 378806016636 8OG recognition residue [nucleotide binding]; other site 378806016637 putative reading head residues; other site 378806016638 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 378806016639 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 378806016640 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 378806016641 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 378806016642 Peptidase family M48; Region: Peptidase_M48; cl12018 378806016643 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 378806016644 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 378806016645 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 378806016646 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 378806016647 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 378806016648 dimerization interface [polypeptide binding]; other site 378806016649 active site 378806016650 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 378806016651 folate binding site [chemical binding]; other site 378806016652 NADP+ binding site [chemical binding]; other site 378806016653 Cytochrome c; Region: Cytochrom_C; cl11414 378806016654 hypothetical protein; Provisional; Region: PRK12705 378806016655 Iron permease FTR1 family; Region: FTR1; cl00475 378806016656 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 378806016657 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 378806016658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806016659 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 378806016660 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806016661 DNA binding residues [nucleotide binding] 378806016662 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 378806016663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806016664 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 378806016665 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 378806016666 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806016667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806016668 Coenzyme A binding pocket [chemical binding]; other site 378806016669 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 378806016670 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806016671 putative catalytic site [active] 378806016672 putative metal binding site [ion binding]; other site 378806016673 putative phosphate binding site [ion binding]; other site 378806016674 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 378806016675 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806016676 Histidine kinase; Region: HisKA_3; pfam07730 378806016677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806016678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378806016679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016680 active site 378806016681 phosphorylation site [posttranslational modification] 378806016682 intermolecular recognition site; other site 378806016683 dimerization interface [polypeptide binding]; other site 378806016684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806016685 DNA binding residues [nucleotide binding] 378806016686 dimerization interface [polypeptide binding]; other site 378806016687 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806016688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806016689 DNA-binding site [nucleotide binding]; DNA binding site 378806016690 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 378806016691 active site 378806016692 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 378806016693 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 378806016694 homodimer interface [polypeptide binding]; other site 378806016695 substrate-cofactor binding pocket; other site 378806016696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806016697 catalytic residue [active] 378806016698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806016699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806016700 ATP binding site [chemical binding]; other site 378806016701 G-X-G motif; other site 378806016702 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806016703 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806016704 active site 378806016705 ATP binding site [chemical binding]; other site 378806016706 substrate binding site [chemical binding]; other site 378806016707 activation loop (A-loop); other site 378806016708 PEGA domain; Region: PEGA; pfam08308 378806016709 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 378806016710 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 378806016711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806016712 Walker A motif; other site 378806016713 ATP binding site [chemical binding]; other site 378806016714 Walker B motif; other site 378806016715 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806016716 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806016717 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 378806016718 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 378806016719 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 378806016720 active site 378806016721 nucleophile elbow; other site 378806016722 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 378806016723 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 378806016724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806016725 TPR motif; other site 378806016726 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806016727 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 378806016728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806016729 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 378806016730 FeS/SAM binding site; other site 378806016731 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 378806016732 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 378806016733 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806016734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378806016735 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 378806016736 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 378806016737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806016738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806016739 dimer interface [polypeptide binding]; other site 378806016740 phosphorylation site [posttranslational modification] 378806016741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806016742 ATP binding site [chemical binding]; other site 378806016743 Mg2+ binding site [ion binding]; other site 378806016744 G-X-G motif; other site 378806016745 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 378806016746 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 378806016747 Ligand binding site [chemical binding]; other site 378806016748 Putative Catalytic site [active] 378806016749 DXD motif; other site 378806016750 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 378806016751 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 378806016752 catalytic residues [active] 378806016753 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 378806016754 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 378806016755 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 378806016756 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 378806016757 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 378806016758 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806016759 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 378806016760 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 378806016761 Ca binding site [ion binding]; other site 378806016762 DNA helicase, putative; Region: TIGR00376 378806016763 PhoH-like protein; Region: PhoH; cl12134 378806016764 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 378806016765 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 378806016766 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 378806016767 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 378806016768 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 378806016769 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 378806016770 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 378806016771 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806016772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806016773 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806016774 active site 378806016775 ATP binding site [chemical binding]; other site 378806016776 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806016777 substrate binding site [chemical binding]; other site 378806016778 activation loop (A-loop); other site 378806016779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806016780 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 378806016781 tellurite resistance protein terB; Region: terB; cd07176 378806016782 putative metal binding site [ion binding]; other site 378806016783 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 378806016784 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 378806016785 Ligand Binding Site [chemical binding]; other site 378806016786 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 378806016787 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 378806016788 putative active site [active] 378806016789 catalytic site [active] 378806016790 putative substrate binding site [chemical binding]; other site 378806016791 HRDC domain; Region: HRDC; cl02578 378806016792 HRDC domain; Region: HRDC; cl02578 378806016793 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 378806016794 dimerization interface [polypeptide binding]; other site 378806016795 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378806016796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806016797 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 378806016798 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 378806016799 active site 378806016800 Zn binding site [ion binding]; other site 378806016801 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 378806016802 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 378806016803 G1 box; other site 378806016804 putative GEF interaction site [polypeptide binding]; other site 378806016805 GTP/Mg2+ binding site [chemical binding]; other site 378806016806 Switch I region; other site 378806016807 G2 box; other site 378806016808 G3 box; other site 378806016809 Switch II region; other site 378806016810 G4 box; other site 378806016811 G5 box; other site 378806016812 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 378806016813 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 378806016814 Putative serine esterase (DUF676); Region: DUF676; pfam05057 378806016815 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 378806016816 Protein of unknown function (DUF990); Region: DUF990; cl01496 378806016817 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 378806016818 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 378806016819 Protein of unknown function (DUF990); Region: DUF990; cl01496 378806016820 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 378806016821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806016822 Walker A/P-loop; other site 378806016823 ATP binding site [chemical binding]; other site 378806016824 Q-loop/lid; other site 378806016825 ABC transporter signature motif; other site 378806016826 Walker B; other site 378806016827 D-loop; other site 378806016828 H-loop/switch region; other site 378806016829 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 378806016830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806016831 S-adenosylmethionine binding site [chemical binding]; other site 378806016832 Uncharacterized conserved protein [Function unknown]; Region: COG4278 378806016833 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 378806016834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806016835 binding surface 378806016836 TPR motif; other site 378806016837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806016838 binding surface 378806016839 TPR motif; other site 378806016840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806016841 TPR motif; other site 378806016842 binding surface 378806016843 CHAT domain; Region: CHAT; cl02083 378806016844 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806016845 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806016846 active site 378806016847 catalytic tetrad [active] 378806016848 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806016849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806016850 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 378806016851 putative effector binding pocket; other site 378806016852 putative dimerization interface [polypeptide binding]; other site 378806016853 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806016854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806016855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806016856 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 378806016857 thioester formation/cholesterol transfer; other site 378806016858 protein-splicing catalytic site; other site 378806016859 PA14 domain; Region: PA14; cl08459 378806016860 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 378806016861 domain; Region: Glyco_hydro_2; pfam00703 378806016862 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 378806016863 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 378806016864 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 378806016865 active site 378806016866 dimer interface [polypeptide binding]; other site 378806016867 motif 1; other site 378806016868 motif 2; other site 378806016869 motif 3; other site 378806016870 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 378806016871 anticodon binding site; other site 378806016872 Peptidase family M54; Region: Peptidase_M54; cl00835 378806016873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806016874 ATP binding site [chemical binding]; other site 378806016875 putative Mg++ binding site [ion binding]; other site 378806016876 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 378806016877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806016878 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 378806016879 Response regulator receiver domain; Region: Response_reg; pfam00072 378806016880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016881 active site 378806016882 phosphorylation site [posttranslational modification] 378806016883 intermolecular recognition site; other site 378806016884 dimerization interface [polypeptide binding]; other site 378806016885 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 378806016886 PilZ domain; Region: PilZ; cl01260 378806016887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 378806016888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806016889 dimer interface [polypeptide binding]; other site 378806016890 phosphorylation site [posttranslational modification] 378806016891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806016892 ATP binding site [chemical binding]; other site 378806016893 Mg2+ binding site [ion binding]; other site 378806016894 G-X-G motif; other site 378806016895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806016896 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 378806016897 FAD binding pocket [chemical binding]; other site 378806016898 FAD binding motif [chemical binding]; other site 378806016899 phosphate binding motif [ion binding]; other site 378806016900 beta-alpha-beta structure motif; other site 378806016901 NAD(p) ribose binding residues [chemical binding]; other site 378806016902 NAD binding pocket [chemical binding]; other site 378806016903 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 378806016904 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 378806016905 NifU-like domain; Region: NifU; cl00484 378806016906 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806016907 FemAB family; Region: FemAB; cl11444 378806016908 Protein of unknown function, DUF482; Region: DUF482; pfam04339 378806016909 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 378806016910 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 378806016911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806016912 Walker A motif; other site 378806016913 ATP binding site [chemical binding]; other site 378806016914 Walker B motif; other site 378806016915 arginine finger; other site 378806016916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806016917 Walker A motif; other site 378806016918 ATP binding site [chemical binding]; other site 378806016919 Walker B motif; other site 378806016920 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378806016921 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 378806016922 Citrate synthase; Region: Citrate_synt; pfam00285 378806016923 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the...; Region: citrate_synt_like_2; cd06102 378806016924 dimer interface [polypeptide binding]; other site 378806016925 active site 378806016926 oxalacetate/citrate binding site [chemical binding]; other site 378806016927 citrylCoA binding site [chemical binding]; other site 378806016928 coenzyme A binding site [chemical binding]; other site 378806016929 catalytic triad [active] 378806016930 Cupin domain; Region: Cupin_2; cl09118 378806016931 GTPase RsgA; Reviewed; Region: PRK01889 378806016932 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 378806016933 GTPase/OB domain interface [polypeptide binding]; other site 378806016934 GTPase/Zn-binding domain interface [polypeptide binding]; other site 378806016935 GTP/Mg2+ binding site [chemical binding]; other site 378806016936 G4 box; other site 378806016937 G5 box; other site 378806016938 G1 box; other site 378806016939 Switch I region; other site 378806016940 G2 box; other site 378806016941 G3 box; other site 378806016942 Switch II region; other site 378806016943 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806016944 dimerization interface [polypeptide binding]; other site 378806016945 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 378806016946 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806016947 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806016948 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 378806016949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806016950 CheB methylesterase; Region: CheB_methylest; pfam01339 378806016951 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 378806016952 putative binding surface; other site 378806016953 active site 378806016954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806016955 ATP binding site [chemical binding]; other site 378806016956 Mg2+ binding site [ion binding]; other site 378806016957 G-X-G motif; other site 378806016958 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 378806016959 Response regulator receiver domain; Region: Response_reg; pfam00072 378806016960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016961 active site 378806016962 phosphorylation site [posttranslational modification] 378806016963 intermolecular recognition site; other site 378806016964 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 378806016965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806016966 Response regulator receiver domain; Region: Response_reg; pfam00072 378806016967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016968 active site 378806016969 phosphorylation site [posttranslational modification] 378806016970 intermolecular recognition site; other site 378806016971 dimerization interface [polypeptide binding]; other site 378806016972 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 378806016973 Response regulator receiver domain; Region: Response_reg; pfam00072 378806016974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806016975 active site 378806016976 phosphorylation site [posttranslational modification] 378806016977 intermolecular recognition site; other site 378806016978 dimerization interface [polypeptide binding]; other site 378806016979 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 378806016980 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 378806016981 NAD binding site [chemical binding]; other site 378806016982 homotetramer interface [polypeptide binding]; other site 378806016983 homodimer interface [polypeptide binding]; other site 378806016984 substrate binding site [chemical binding]; other site 378806016985 active site 378806016986 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 378806016987 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 378806016988 TPP-binding site [chemical binding]; other site 378806016989 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 378806016990 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 378806016991 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 378806016992 E3 interaction surface; other site 378806016993 lipoyl attachment site [posttranslational modification]; other site 378806016994 e3 binding domain; Region: E3_binding; pfam02817 378806016995 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 378806016996 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 378806016997 DNA-binding site [nucleotide binding]; DNA binding site 378806016998 RNA-binding motif; other site 378806016999 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 378806017000 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806017001 UPF0489 domain; Region: UPF0489; pfam12640 378806017002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017003 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806017004 active site 378806017005 ATP binding site [chemical binding]; other site 378806017006 substrate binding site [chemical binding]; other site 378806017007 activation loop (A-loop); other site 378806017008 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806017009 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 378806017010 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806017011 Integrase core domain; Region: rve; cl01316 378806017012 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806017013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806017014 active site 378806017015 catalytic tetrad [active] 378806017016 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378806017017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806017018 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 378806017019 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 378806017020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806017021 putative substrate translocation pore; other site 378806017022 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806017023 putative peptidoglycan binding site; other site 378806017024 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806017025 putative peptidoglycan binding site; other site 378806017026 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806017027 putative peptidoglycan binding site; other site 378806017028 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 378806017029 catalytic residue [active] 378806017030 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 378806017031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806017032 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 378806017033 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 378806017034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 378806017035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806017036 NAD(P) binding site [chemical binding]; other site 378806017037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806017038 active site 378806017039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806017040 kelch-like protein; Provisional; Region: PHA03098 378806017041 kelch-like protein; Provisional; Region: PHA03098 378806017042 Kelch motif; Region: Kelch_1; cl02701 378806017043 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 378806017044 Surface antigen; Region: Bac_surface_Ag; cl03097 378806017045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017046 active site 378806017047 phosphorylation site [posttranslational modification] 378806017048 intermolecular recognition site; other site 378806017049 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 378806017050 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 378806017051 cobalamin binding residues [chemical binding]; other site 378806017052 putative BtuC binding residues; other site 378806017053 dimer interface [polypeptide binding]; other site 378806017054 Protein kinase domain; Region: Pkinase; pfam00069 378806017055 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017056 active site 378806017057 ATP binding site [chemical binding]; other site 378806017058 substrate binding site [chemical binding]; other site 378806017059 activation loop (A-loop); other site 378806017060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806017061 TPR motif; other site 378806017062 binding surface 378806017063 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 378806017064 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806017065 N-terminal plug; other site 378806017066 ligand-binding site [chemical binding]; other site 378806017067 Response regulator receiver domain; Region: Response_reg; pfam00072 378806017068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017069 active site 378806017070 phosphorylation site [posttranslational modification] 378806017071 intermolecular recognition site; other site 378806017072 dimerization interface [polypeptide binding]; other site 378806017073 Transglycosylase; Region: Transgly; cl07896 378806017074 Pirin-related protein [General function prediction only]; Region: COG1741 378806017075 Cupin domain; Region: Cupin_2; cl09118 378806017076 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 378806017077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017078 Protein kinase domain; Region: Pkinase; pfam00069 378806017079 active site 378806017080 ATP binding site [chemical binding]; other site 378806017081 substrate binding site [chemical binding]; other site 378806017082 activation loop (A-loop); other site 378806017083 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 378806017084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806017085 DoxX; Region: DoxX; cl00976 378806017086 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806017087 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 378806017088 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 378806017089 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 378806017090 Moco binding site; other site 378806017091 metal coordination site [ion binding]; other site 378806017092 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 378806017093 Fatty acid desaturase; Region: FA_desaturase; pfam00487 378806017094 putative di-iron ligands [ion binding]; other site 378806017095 Nudix hydrolase homolog; Region: PLN02791 378806017096 heat shock protein 90; Provisional; Region: PRK05218 378806017097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806017098 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 378806017099 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 378806017100 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 378806017101 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 378806017102 active site 378806017103 ribulose/triose binding site [chemical binding]; other site 378806017104 phosphate binding site [ion binding]; other site 378806017105 substrate (anthranilate) binding pocket [chemical binding]; other site 378806017106 product (indole) binding pocket [chemical binding]; other site 378806017107 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 378806017108 active site 378806017109 tryptophan synthase, beta chain; Region: PLN02618 378806017110 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 378806017111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806017112 catalytic residue [active] 378806017113 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 378806017114 substrate binding site [chemical binding]; other site 378806017115 active site 378806017116 catalytic residues [active] 378806017117 heterodimer interface [polypeptide binding]; other site 378806017118 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 378806017119 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 378806017120 glutamine binding [chemical binding]; other site 378806017121 catalytic triad [active] 378806017122 anthranilate synthase component I; Provisional; Region: PRK13565 378806017123 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 378806017124 chorismate binding enzyme; Region: Chorismate_bind; cl10555 378806017125 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 378806017126 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806017127 ATP-dependent DNA ligase; Validated; Region: PRK09247 378806017128 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 378806017129 active site 378806017130 DNA binding site [nucleotide binding] 378806017131 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 378806017132 DNA binding site [nucleotide binding] 378806017133 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 378806017134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806017135 ATP binding site [chemical binding]; other site 378806017136 putative Mg++ binding site [ion binding]; other site 378806017137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806017138 nucleotide binding region [chemical binding]; other site 378806017139 ATP-binding site [chemical binding]; other site 378806017140 DEAD/H associated; Region: DEAD_assoc; pfam08494 378806017141 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 378806017142 putative active site [active] 378806017143 putative metal binding site [ion binding]; other site 378806017144 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 378806017145 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 378806017146 heme-binding residues [chemical binding]; other site 378806017147 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 378806017148 molybdopterin cofactor binding site; other site 378806017149 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 378806017150 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 378806017151 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl01295 378806017152 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 378806017153 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 378806017154 Cytochrome c; Region: Cytochrom_C; cl11414 378806017155 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 378806017156 Cu(I) binding site [ion binding]; other site 378806017157 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 378806017158 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 378806017159 D-pathway; other site 378806017160 Low-spin heme binding site [chemical binding]; other site 378806017161 Putative water exit pathway; other site 378806017162 Binuclear center (active site) [active] 378806017163 K-pathway; other site 378806017164 Putative proton exit pathway; other site 378806017165 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits...; Region: NorE_like; cd02862 378806017166 Subunit I/III interface [polypeptide binding]; other site 378806017167 caa(3)-type oxidase, subunit IV; Region: caa3_sub_IV; TIGR02229 378806017168 Protein of unknown function, DUF481; Region: DUF481; cl01213 378806017169 Flagellin N-methylase; Region: FliB; cl00497 378806017170 putative hydrolase; Provisional; Region: PRK10985 378806017171 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806017172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806017173 RmuC family; Region: RmuC; pfam02646 378806017174 DEAD_2; Region: DEAD_2; cl14887 378806017175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806017176 ATP binding site [chemical binding]; other site 378806017177 putative Mg++ binding site [ion binding]; other site 378806017178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806017179 nucleotide binding region [chemical binding]; other site 378806017180 ATP-binding site [chemical binding]; other site 378806017181 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 378806017182 Protein of unknown function (DUF790); Region: DUF790; pfam05626 378806017183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806017184 sequence-specific DNA binding site [nucleotide binding]; other site 378806017185 salt bridge; other site 378806017186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017187 active site 378806017188 phosphorylation site [posttranslational modification] 378806017189 intermolecular recognition site; other site 378806017190 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806017191 Thioesterase domain; Region: Thioesterase; pfam00975 378806017192 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 378806017193 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 378806017194 PYR/PP interface [polypeptide binding]; other site 378806017195 dimer interface [polypeptide binding]; other site 378806017196 TPP binding site [chemical binding]; other site 378806017197 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378806017198 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 378806017199 TPP-binding site [chemical binding]; other site 378806017200 dimer interface [polypeptide binding]; other site 378806017201 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 378806017202 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 378806017203 putative valine binding site [chemical binding]; other site 378806017204 dimer interface [polypeptide binding]; other site 378806017205 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 378806017206 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 378806017207 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 378806017208 homodimer interface [polypeptide binding]; other site 378806017209 substrate-cofactor binding pocket; other site 378806017210 catalytic residue [active] 378806017211 ketol-acid reductoisomerase; Provisional; Region: PRK05479 378806017212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806017213 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 378806017214 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 378806017215 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 378806017216 C-terminal domain interface [polypeptide binding]; other site 378806017217 GSH binding site (G-site) [chemical binding]; other site 378806017218 dimer interface [polypeptide binding]; other site 378806017219 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 378806017220 dimer interface [polypeptide binding]; other site 378806017221 N-terminal domain interface [polypeptide binding]; other site 378806017222 putative substrate binding pocket (H-site) [chemical binding]; other site 378806017223 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 378806017224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806017225 Walker A motif; other site 378806017226 ATP binding site [chemical binding]; other site 378806017227 Walker B motif; other site 378806017228 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 378806017229 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 378806017230 active site 378806017231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806017232 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806017233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806017234 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806017235 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378806017236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806017237 Membrane transport protein; Region: Mem_trans; cl09117 378806017238 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 378806017239 putative active site [active] 378806017240 putative metal binding site [ion binding]; other site 378806017241 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 378806017242 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 378806017243 heterodimer interface [polypeptide binding]; other site 378806017244 substrate interaction site [chemical binding]; other site 378806017245 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 378806017246 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 378806017247 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679 378806017248 active site 378806017249 substrate binding site [chemical binding]; other site 378806017250 coenzyme B12 binding site [chemical binding]; other site 378806017251 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 378806017252 B12 binding site [chemical binding]; other site 378806017253 cobalt ligand [ion binding]; other site 378806017254 membrane ATPase/protein kinase; Provisional; Region: PRK09435 378806017255 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 378806017256 Walker A; other site 378806017257 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 378806017258 B12 binding site [chemical binding]; other site 378806017259 cobalt ligand [ion binding]; other site 378806017260 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 378806017261 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 378806017262 Walker A; other site 378806017263 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 378806017264 N-formylglutamate amidohydrolase; Region: FGase; cl01522 378806017265 Isochorismatase family; Region: Isochorismatase; pfam00857 378806017266 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 378806017267 catalytic triad [active] 378806017268 conserved cis-peptide bond; other site 378806017269 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 378806017270 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 378806017271 Protein kinase domain; Region: Pkinase; pfam00069 378806017272 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017273 active site 378806017274 ATP binding site [chemical binding]; other site 378806017275 substrate binding site [chemical binding]; other site 378806017276 activation loop (A-loop); other site 378806017277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806017278 S-adenosylmethionine binding site [chemical binding]; other site 378806017279 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 378806017280 active site 378806017281 metal binding site [ion binding]; metal-binding site 378806017282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806017283 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017284 active site 378806017285 ATP binding site [chemical binding]; other site 378806017286 substrate binding site [chemical binding]; other site 378806017287 activation loop (A-loop); other site 378806017288 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 378806017289 active site 378806017290 zinc binding site [ion binding]; other site 378806017291 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 378806017292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806017293 DNA binding residues [nucleotide binding] 378806017294 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 378806017295 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017296 active site 378806017297 ATP binding site [chemical binding]; other site 378806017298 substrate binding site [chemical binding]; other site 378806017299 activation loop (A-loop); other site 378806017300 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 378806017301 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378806017302 DNA binding site [nucleotide binding] 378806017303 active site 378806017304 Int/Topo IB signature motif; other site 378806017305 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 378806017306 helix-hairpin-helix signature motif; other site 378806017307 active site 378806017308 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 378806017309 Ligand Binding Site [chemical binding]; other site 378806017310 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 378806017311 ATP binding site [chemical binding]; other site 378806017312 substrate binding site [chemical binding]; other site 378806017313 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 378806017314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 378806017315 Putative addiction module component; Region: Unstab_antitox; cl09921 378806017316 Response regulator receiver domain; Region: Response_reg; pfam00072 378806017317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017318 active site 378806017319 phosphorylation site [posttranslational modification] 378806017320 intermolecular recognition site; other site 378806017321 dimerization interface [polypeptide binding]; other site 378806017322 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 378806017323 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 378806017324 substrate binding site [chemical binding]; other site 378806017325 hexamer interface [polypeptide binding]; other site 378806017326 metal binding site [ion binding]; metal-binding site 378806017327 GAF domain; Region: GAF; cl00853 378806017328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 378806017329 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 378806017330 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 378806017331 pyruvate kinase; Provisional; Region: PRK05826 378806017332 domain interfaces; other site 378806017333 active site 378806017334 Flagellin N-methylase; Region: FliB; cl00497 378806017335 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 378806017336 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 378806017337 Domain of unknown function (DUF814); Region: DUF814; pfam05670 378806017338 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 378806017339 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 378806017340 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 378806017341 FMN binding site [chemical binding]; other site 378806017342 active site 378806017343 catalytic residues [active] 378806017344 substrate binding site [chemical binding]; other site 378806017345 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 378806017346 active site 378806017347 putative substrate binding region [chemical binding]; other site 378806017348 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 378806017349 Di-iron ligands [ion binding]; other site 378806017350 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806017351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806017352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806017353 Multicopper oxidase; Region: Cu-oxidase; cl14658 378806017354 Multicopper oxidase; Region: Cu-oxidase; cl14658 378806017355 Outer membrane efflux protein; Region: OEP; pfam02321 378806017356 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 378806017357 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 378806017358 metal-binding site [ion binding] 378806017359 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 378806017360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806017361 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 378806017362 Cupin domain; Region: Cupin_2; cl09118 378806017363 Pirin-related protein [General function prediction only]; Region: COG1741 378806017364 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 378806017365 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 378806017366 putative hydrophobic ligand binding site [chemical binding]; other site 378806017367 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 378806017368 putative hydrophobic ligand binding site [chemical binding]; other site 378806017369 Cytochrome P450; Region: p450; cl12078 378806017370 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806017371 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806017372 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 378806017373 catalytic triad [active] 378806017374 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806017375 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 378806017376 active site 378806017377 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017378 active site 378806017379 ATP binding site [chemical binding]; other site 378806017380 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806017381 substrate binding site [chemical binding]; other site 378806017382 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806017383 substrate binding site [chemical binding]; other site 378806017384 activation loop (A-loop); other site 378806017385 activation loop (A-loop); other site 378806017386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806017387 binding surface 378806017388 TPR motif; other site 378806017389 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 378806017390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806017391 binding surface 378806017392 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 378806017393 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806017394 GAF domain; Region: GAF; cl00853 378806017395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 378806017396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017397 ATP binding site [chemical binding]; other site 378806017398 Mg2+ binding site [ion binding]; other site 378806017399 G-X-G motif; other site 378806017400 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 378806017401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806017402 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 378806017403 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806017404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806017405 DNA-binding site [nucleotide binding]; DNA binding site 378806017406 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 378806017407 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 378806017408 active site 378806017409 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806017410 active site 378806017411 ATP binding site [chemical binding]; other site 378806017412 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806017413 substrate binding site [chemical binding]; other site 378806017414 activation loop (A-loop); other site 378806017415 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806017416 cyclase homology domain; Region: CHD; cd07302 378806017417 nucleotidyl binding site; other site 378806017418 metal binding site [ion binding]; metal-binding site 378806017419 dimer interface [polypeptide binding]; other site 378806017420 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 378806017421 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 378806017422 DGQHR domain; Region: DGQHR; cl14002 378806017423 Putative cyclase; Region: Cyclase; cl00814 378806017424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806017425 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain; Region: NMT_C; pfam02799 378806017426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806017427 S-adenosylmethionine binding site [chemical binding]; other site 378806017428 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 378806017429 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017430 active site 378806017431 ATP binding site [chemical binding]; other site 378806017432 substrate binding site [chemical binding]; other site 378806017433 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806017434 activation loop (A-loop); other site 378806017435 short chain dehydrogenase; Provisional; Region: PRK05693 378806017436 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 378806017437 NADP binding site [chemical binding]; other site 378806017438 active site 378806017439 steroid binding site; other site 378806017440 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 378806017441 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 378806017442 active site 378806017443 putative substrate binding pocket [chemical binding]; other site 378806017444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806017445 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806017446 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 378806017447 C-terminal domain interface [polypeptide binding]; other site 378806017448 GSH binding site (G-site) [chemical binding]; other site 378806017449 dimer interface [polypeptide binding]; other site 378806017450 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 378806017451 N-terminal domain interface [polypeptide binding]; other site 378806017452 dimer interface [polypeptide binding]; other site 378806017453 substrate binding pocket (H-site) [chemical binding]; other site 378806017454 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017455 Protein kinase domain; Region: Pkinase; pfam00069 378806017456 active site 378806017457 ATP binding site [chemical binding]; other site 378806017458 substrate binding site [chemical binding]; other site 378806017459 activation loop (A-loop); other site 378806017460 Integrase core domain; Region: rve; cl01316 378806017461 Polyphosphate kinase; Region: PP_kinase; pfam02503 378806017462 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 378806017463 putative domain interface [polypeptide binding]; other site 378806017464 putative active site [active] 378806017465 catalytic site [active] 378806017466 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 378806017467 putative domain interface [polypeptide binding]; other site 378806017468 putative active site [active] 378806017469 catalytic site [active] 378806017470 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 378806017471 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 378806017472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 378806017473 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 378806017474 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 378806017475 NAD binding site [chemical binding]; other site 378806017476 catalytic Zn binding site [ion binding]; other site 378806017477 structural Zn binding site [ion binding]; other site 378806017478 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 378806017479 ATP adenylyltransferase; Region: ATP_transf; pfam09830 378806017480 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 378806017481 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806017482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017483 ATP binding site [chemical binding]; other site 378806017484 Mg2+ binding site [ion binding]; other site 378806017485 G-X-G motif; other site 378806017486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017487 active site 378806017488 phosphorylation site [posttranslational modification] 378806017489 intermolecular recognition site; other site 378806017490 dimerization interface [polypeptide binding]; other site 378806017491 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 378806017492 isocitrate dehydrogenase; Validated; Region: PRK06451 378806017493 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 378806017494 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 378806017495 catalytic residues [active] 378806017496 dimer interface [polypeptide binding]; other site 378806017497 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 378806017498 catalytic residues [active] 378806017499 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 378806017500 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 378806017501 catalytic triad [active] 378806017502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806017503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806017504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806017505 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 378806017506 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 378806017507 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 378806017508 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806017509 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806017510 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378806017511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806017512 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 378806017513 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 378806017514 catalytic residue [active] 378806017515 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 378806017516 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 378806017517 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 378806017518 PYR/PP interface [polypeptide binding]; other site 378806017519 dimer interface [polypeptide binding]; other site 378806017520 TPP binding site [chemical binding]; other site 378806017521 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378806017522 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 378806017523 TPP-binding site [chemical binding]; other site 378806017524 KduI/IolB family; Region: KduI; cl01508 378806017525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806017526 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 378806017527 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806017528 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 378806017529 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806017530 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806017531 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 378806017532 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 378806017533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806017534 S-adenosylmethionine binding site [chemical binding]; other site 378806017535 enoyl-CoA hydratase; Provisional; Region: PRK06142 378806017536 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 378806017537 substrate binding site [chemical binding]; other site 378806017538 oxyanion hole (OAH) forming residues; other site 378806017539 trimer interface [polypeptide binding]; other site 378806017540 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 378806017541 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806017542 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806017543 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806017544 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806017545 Condensation domain; Region: Condensation; cl09290 378806017546 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 378806017547 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806017548 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806017549 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806017550 Condensation domain; Region: Condensation; cl09290 378806017551 Nonribosomal peptide synthase; Region: NRPS; pfam08415 378806017552 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 378806017553 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806017554 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806017555 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806017556 Condensation domain; Region: Condensation; cl09290 378806017557 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 378806017558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806017559 S-adenosylmethionine binding site [chemical binding]; other site 378806017560 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 378806017561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806017562 motif II; other site 378806017563 photosystem I reaction center protein PsaO; Provisional; Region: PLN00046; cl11846 378806017564 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 378806017565 short chain dehydrogenase; Provisional; Region: PRK06123 378806017566 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 378806017567 NADP binding site [chemical binding]; other site 378806017568 substrate binding site [chemical binding]; other site 378806017569 active site 378806017570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017571 dimer interface [polypeptide binding]; other site 378806017572 phosphorylation site [posttranslational modification] 378806017573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017574 ATP binding site [chemical binding]; other site 378806017575 Mg2+ binding site [ion binding]; other site 378806017576 G-X-G motif; other site 378806017577 Response regulator receiver domain; Region: Response_reg; pfam00072 378806017578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017579 active site 378806017580 phosphorylation site [posttranslational modification] 378806017581 intermolecular recognition site; other site 378806017582 dimerization interface [polypeptide binding]; other site 378806017583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017584 dimer interface [polypeptide binding]; other site 378806017585 phosphorylation site [posttranslational modification] 378806017586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017587 ATP binding site [chemical binding]; other site 378806017588 Mg2+ binding site [ion binding]; other site 378806017589 G-X-G motif; other site 378806017590 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806017591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017592 dimer interface [polypeptide binding]; other site 378806017593 phosphorylation site [posttranslational modification] 378806017594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017595 ATP binding site [chemical binding]; other site 378806017596 Mg2+ binding site [ion binding]; other site 378806017597 G-X-G motif; other site 378806017598 Response regulator receiver domain; Region: Response_reg; pfam00072 378806017599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017600 active site 378806017601 phosphorylation site [posttranslational modification] 378806017602 intermolecular recognition site; other site 378806017603 dimerization interface [polypeptide binding]; other site 378806017604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017605 dimer interface [polypeptide binding]; other site 378806017606 phosphorylation site [posttranslational modification] 378806017607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017608 ATP binding site [chemical binding]; other site 378806017609 Mg2+ binding site [ion binding]; other site 378806017610 G-X-G motif; other site 378806017611 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806017612 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806017613 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 378806017614 MoaE interaction surface [polypeptide binding]; other site 378806017615 MoeB interaction surface [polypeptide binding]; other site 378806017616 thiocarboxylated glycine; other site 378806017617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806017618 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 378806017619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806017620 motif II; other site 378806017621 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 378806017622 phosphate binding site [ion binding]; other site 378806017623 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806017624 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 378806017625 putative C-terminal domain interface [polypeptide binding]; other site 378806017626 putative GSH binding site (G-site) [chemical binding]; other site 378806017627 putative dimer interface [polypeptide binding]; other site 378806017628 GST_C family, unknown subfamily 8; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_8; cd03207 378806017629 putative N-terminal domain interface [polypeptide binding]; other site 378806017630 putative dimer interface [polypeptide binding]; other site 378806017631 putative substrate binding pocket (H-site) [chemical binding]; other site 378806017632 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806017633 Bacterial SH3 domain; Region: SH3_3; cl02551 378806017634 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806017635 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806017636 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_4; cd03795 378806017637 putative ADP-binding pocket [chemical binding]; other site 378806017638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806017639 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 378806017640 Chain length determinant protein; Region: Wzz; cl01623 378806017641 Chain length determinant protein; Region: Wzz; cl01623 378806017642 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806017643 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378806017644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806017645 S-adenosylmethionine binding site [chemical binding]; other site 378806017646 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378806017647 putative acyl-acceptor binding pocket; other site 378806017648 CARDB; Region: CARDB; pfam07705 378806017649 HYR domain; Region: HYR; pfam02494 378806017650 HYR domain; Region: HYR; pfam02494 378806017651 HYR domain; Region: HYR; pfam02494 378806017652 Cytochrome c; Region: Cytochrom_C; cl11414 378806017653 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 378806017654 GAF domain; Region: GAF; cl00853 378806017655 cyclase homology domain; Region: CHD; cd07302 378806017656 nucleotidyl binding site; other site 378806017657 metal binding site [ion binding]; metal-binding site 378806017658 dimer interface [polypeptide binding]; other site 378806017659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806017660 PAS fold; Region: PAS_4; pfam08448 378806017661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017662 dimer interface [polypeptide binding]; other site 378806017663 phosphorylation site [posttranslational modification] 378806017664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017665 ATP binding site [chemical binding]; other site 378806017666 Mg2+ binding site [ion binding]; other site 378806017667 G-X-G motif; other site 378806017668 transcription-repair coupling factor; Provisional; Region: PRK10689 378806017669 transcription-repair coupling factor; Region: mfd; TIGR00580 378806017670 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 378806017671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806017672 ATP binding site [chemical binding]; other site 378806017673 putative Mg++ binding site [ion binding]; other site 378806017674 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806017675 nucleotide binding region [chemical binding]; other site 378806017676 ATP-binding site [chemical binding]; other site 378806017677 TRCF domain; Region: TRCF; pfam03461 378806017678 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806017679 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_subtilisin_1; cd04818 378806017680 PA/protease or protease-like domain interface [polypeptide binding]; other site 378806017681 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 378806017682 Zn binding site [ion binding]; other site 378806017683 Putative Ig domain; Region: He_PIG; cl09256 378806017684 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 378806017685 Putative Ig domain; Region: He_PIG; cl09256 378806017686 REJ domain; Region: REJ; pfam02010 378806017687 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 378806017688 periplasmic folding chaperone; Provisional; Region: PRK10788 378806017689 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 378806017690 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 378806017691 metal binding site [ion binding]; metal-binding site 378806017692 putative dimer interface [polypeptide binding]; other site 378806017693 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 378806017694 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806017695 active site 378806017696 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 378806017697 dinuclear metal binding motif [ion binding]; other site 378806017698 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 378806017699 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 378806017700 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 378806017701 active site 378806017702 DNA binding site [nucleotide binding] 378806017703 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 378806017704 DNA binding site [nucleotide binding] 378806017705 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 378806017706 nucleotide binding site [chemical binding]; other site 378806017707 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 378806017708 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 378806017709 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 378806017710 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 378806017711 Protein of unknown function (DUF420); Region: DUF420; cl00989 378806017712 Response regulator receiver domain; Region: Response_reg; pfam00072 378806017713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017714 active site 378806017715 phosphorylation site [posttranslational modification] 378806017716 intermolecular recognition site; other site 378806017717 dimerization interface [polypeptide binding]; other site 378806017718 sensory histidine kinase CreC; Provisional; Region: PRK11100 378806017719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017720 ATP binding site [chemical binding]; other site 378806017721 Mg2+ binding site [ion binding]; other site 378806017722 G-X-G motif; other site 378806017723 Response regulator receiver domain; Region: Response_reg; pfam00072 378806017724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017725 active site 378806017726 phosphorylation site [posttranslational modification] 378806017727 intermolecular recognition site; other site 378806017728 dimerization interface [polypeptide binding]; other site 378806017729 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 378806017730 GAF domain; Region: GAF; cl00853 378806017731 Phytochrome region; Region: PHY; pfam00360 378806017732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017733 dimer interface [polypeptide binding]; other site 378806017734 phosphorylation site [posttranslational modification] 378806017735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017736 ATP binding site [chemical binding]; other site 378806017737 Mg2+ binding site [ion binding]; other site 378806017738 G-X-G motif; other site 378806017739 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 378806017740 heme binding pocket [chemical binding]; other site 378806017741 heme ligand [chemical binding]; other site 378806017742 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 378806017743 active site 378806017744 catalytic triad [active] 378806017745 ATP-dependent helicase; Provisional; Region: PRK13767 378806017746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806017747 ATP binding site [chemical binding]; other site 378806017748 putative Mg++ binding site [ion binding]; other site 378806017749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806017750 nucleotide binding region [chemical binding]; other site 378806017751 ATP-binding site [chemical binding]; other site 378806017752 DEAD/H associated; Region: DEAD_assoc; pfam08494 378806017753 quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906 378806017754 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806017755 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 378806017756 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 378806017757 dimer interface [polypeptide binding]; other site 378806017758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806017759 catalytic residue [active] 378806017760 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 378806017761 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 378806017762 iron-sulfur cluster [ion binding]; other site 378806017763 [2Fe-2S] cluster binding site [ion binding]; other site 378806017764 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 378806017765 hydrophobic ligand binding site; other site 378806017766 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 378806017767 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 378806017768 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806017769 putative sugar binding sites [chemical binding]; other site 378806017770 Q-X-W motif; other site 378806017771 putative diguanylate cyclase; Provisional; Region: PRK09776 378806017772 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 378806017773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806017774 PAS fold; Region: PAS_3; pfam08447 378806017775 putative active site [active] 378806017776 heme pocket [chemical binding]; other site 378806017777 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806017778 GAF domain; Region: GAF; cl00853 378806017779 PAS domain S-box; Region: sensory_box; TIGR00229 378806017780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806017781 putative active site [active] 378806017782 heme pocket [chemical binding]; other site 378806017783 sensor protein ZraS; Provisional; Region: PRK10364 378806017784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017785 ATP binding site [chemical binding]; other site 378806017786 Mg2+ binding site [ion binding]; other site 378806017787 G-X-G motif; other site 378806017788 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806017789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017790 active site 378806017791 phosphorylation site [posttranslational modification] 378806017792 intermolecular recognition site; other site 378806017793 dimerization interface [polypeptide binding]; other site 378806017794 Response regulator receiver domain; Region: Response_reg; pfam00072 378806017795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017796 active site 378806017797 phosphorylation site [posttranslational modification] 378806017798 intermolecular recognition site; other site 378806017799 dimerization interface [polypeptide binding]; other site 378806017800 Peptidase M14-like domain of an uncharacterized group of Peptidase M14 Carboxypeptidase (CP) T (CPT)-like proteins. This group belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-...; Region: M14_CPT_like; cd06226 378806017801 putative active site [active] 378806017802 Zn-binding site [ion binding]; other site 378806017803 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 378806017804 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 378806017805 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 378806017806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806017807 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 378806017808 active site 378806017809 metal binding site [ion binding]; metal-binding site 378806017810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806017811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806017812 active site 378806017813 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017814 active site 378806017815 ATP binding site [chemical binding]; other site 378806017816 substrate binding site [chemical binding]; other site 378806017817 activation loop (A-loop); other site 378806017818 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 378806017819 Phosphate transporter family; Region: PHO4; cl00396 378806017820 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 378806017821 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806017822 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_1_4; cd06241 378806017823 putative active site [active] 378806017824 Zn-binding site [ion binding]; other site 378806017825 PilZ domain; Region: PilZ; cl01260 378806017826 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 378806017827 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806017828 Walker A/P-loop; other site 378806017829 ATP binding site [chemical binding]; other site 378806017830 Q-loop/lid; other site 378806017831 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806017832 Q-loop/lid; other site 378806017833 ABC transporter signature motif; other site 378806017834 Walker B; other site 378806017835 D-loop; other site 378806017836 H-loop/switch region; other site 378806017837 exonuclease subunit SbcD; Provisional; Region: PRK10966 378806017838 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 378806017839 active site 378806017840 metal binding site [ion binding]; metal-binding site 378806017841 DNA binding site [nucleotide binding] 378806017842 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 378806017843 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378806017844 putative acyl-acceptor binding pocket; other site 378806017845 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806017846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806017847 NAD(P) binding site [chemical binding]; other site 378806017848 active site 378806017849 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 378806017850 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 378806017851 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 378806017852 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 378806017853 putative active site [active] 378806017854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806017855 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 378806017856 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 378806017857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378806017858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017859 active site 378806017860 phosphorylation site [posttranslational modification] 378806017861 intermolecular recognition site; other site 378806017862 dimerization interface [polypeptide binding]; other site 378806017863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 378806017864 DNA binding site [nucleotide binding] 378806017865 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806017866 dimerization interface [polypeptide binding]; other site 378806017867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017868 dimer interface [polypeptide binding]; other site 378806017869 phosphorylation site [posttranslational modification] 378806017870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017871 ATP binding site [chemical binding]; other site 378806017872 G-X-G motif; other site 378806017873 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806017874 GAF domain; Region: GAF; cl00853 378806017875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017876 dimer interface [polypeptide binding]; other site 378806017877 phosphorylation site [posttranslational modification] 378806017878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017879 ATP binding site [chemical binding]; other site 378806017880 Mg2+ binding site [ion binding]; other site 378806017881 G-X-G motif; other site 378806017882 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017883 Protein kinase domain; Region: Pkinase; pfam00069 378806017884 active site 378806017885 ATP binding site [chemical binding]; other site 378806017886 substrate binding site [chemical binding]; other site 378806017887 activation loop (A-loop); other site 378806017888 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806017889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806017890 DNA-binding site [nucleotide binding]; DNA binding site 378806017891 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806017892 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806017893 Predicted transcriptional regulator [Transcription]; Region: COG2378 378806017894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806017895 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806017896 acetyl-CoA synthetase; Provisional; Region: PRK04319 378806017897 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806017898 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806017899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017900 active site 378806017901 ATP binding site [chemical binding]; other site 378806017902 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806017903 substrate binding site [chemical binding]; other site 378806017904 activation loop (A-loop); other site 378806017905 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806017906 Predicted ATPase [General function prediction only]; Region: COG3899 378806017907 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806017908 phosphopeptide binding site; other site 378806017909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806017910 PAS fold; Region: PAS_3; pfam08447 378806017911 putative active site [active] 378806017912 heme pocket [chemical binding]; other site 378806017913 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806017914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806017915 putative active site [active] 378806017916 heme pocket [chemical binding]; other site 378806017917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017918 dimer interface [polypeptide binding]; other site 378806017919 phosphorylation site [posttranslational modification] 378806017920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017921 ATP binding site [chemical binding]; other site 378806017922 Mg2+ binding site [ion binding]; other site 378806017923 G-X-G motif; other site 378806017924 Response regulator receiver domain; Region: Response_reg; pfam00072 378806017925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017926 active site 378806017927 phosphorylation site [posttranslational modification] 378806017928 intermolecular recognition site; other site 378806017929 dimerization interface [polypeptide binding]; other site 378806017930 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806017931 active site 378806017932 ATP binding site [chemical binding]; other site 378806017933 substrate binding site [chemical binding]; other site 378806017934 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806017935 activation loop (A-loop); other site 378806017936 benzoate transport; Region: 2A0115; TIGR00895 378806017937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806017938 putative substrate translocation pore; other site 378806017939 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 378806017940 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 378806017941 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806017942 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806017943 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806017944 calcium binding site 2 [ion binding]; other site 378806017945 active site 378806017946 catalytic triad [active] 378806017947 calcium binding site 1 [ion binding]; other site 378806017948 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 378806017949 DNA binding residues [nucleotide binding] 378806017950 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 378806017951 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 378806017952 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 378806017953 DNA binding residues [nucleotide binding] 378806017954 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cd02065 378806017955 B12 binding site [chemical binding]; other site 378806017956 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 378806017957 putative acyl-acceptor binding pocket; other site 378806017958 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 378806017959 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 378806017960 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 378806017961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806017962 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 378806017963 active site lid residues [active] 378806017964 substrate binding pocket [chemical binding]; other site 378806017965 catalytic residues [active] 378806017966 substrate-Mg2+ binding site; other site 378806017967 aspartate-rich region 1; other site 378806017968 aspartate-rich region 2; other site 378806017969 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 378806017970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806017971 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 378806017972 substrate binding pocket [chemical binding]; other site 378806017973 chain length determination region; other site 378806017974 substrate-Mg2+ binding site; other site 378806017975 catalytic residues [active] 378806017976 aspartate-rich region 1; other site 378806017977 active site lid residues [active] 378806017978 aspartate-rich region 2; other site 378806017979 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806017980 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 378806017981 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 378806017982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806017983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806017984 dimer interface [polypeptide binding]; other site 378806017985 phosphorylation site [posttranslational modification] 378806017986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806017987 ATP binding site [chemical binding]; other site 378806017988 Mg2+ binding site [ion binding]; other site 378806017989 G-X-G motif; other site 378806017990 Response regulator receiver domain; Region: Response_reg; pfam00072 378806017991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806017992 active site 378806017993 phosphorylation site [posttranslational modification] 378806017994 intermolecular recognition site; other site 378806017995 dimerization interface [polypeptide binding]; other site 378806017996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806017997 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 378806017998 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 378806017999 NADP binding site [chemical binding]; other site 378806018000 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 378806018001 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806018002 putative active site [active] 378806018003 putative metal binding site [ion binding]; other site 378806018004 Bacterial SH3 domain; Region: SH3_3; cl02551 378806018005 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806018006 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 378806018007 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 378806018008 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806018009 active site 378806018010 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 378806018011 generic binding surface I; other site 378806018012 generic binding surface II; other site 378806018013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018014 active site 378806018015 ATP binding site [chemical binding]; other site 378806018016 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806018017 substrate binding site [chemical binding]; other site 378806018018 activation loop (A-loop); other site 378806018019 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806018020 phosphopeptide binding site; other site 378806018021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806018022 binding surface 378806018023 TPR motif; other site 378806018024 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806018025 active site 378806018026 ATP binding site [chemical binding]; other site 378806018027 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806018028 substrate binding site [chemical binding]; other site 378806018029 activation loop (A-loop); other site 378806018030 PEGA domain; Region: PEGA; pfam08308 378806018031 hypothetical protein; Provisional; Region: PRK07338 378806018032 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 378806018033 metal binding site [ion binding]; metal-binding site 378806018034 dimer interface [polypeptide binding]; other site 378806018035 Protein required for attachment to host cells; Region: Host_attach; cl02398 378806018036 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 378806018037 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806018038 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806018039 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 378806018040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806018041 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043 378806018042 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806018043 putative C-terminal domain interface [polypeptide binding]; other site 378806018044 putative GSH binding site (G-site) [chemical binding]; other site 378806018045 putative dimer interface [polypeptide binding]; other site 378806018046 GST_C family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_3; cd03194 378806018047 putative N-terminal domain interface [polypeptide binding]; other site 378806018048 putative dimer interface [polypeptide binding]; other site 378806018049 putative substrate binding pocket (H-site) [chemical binding]; other site 378806018050 cyclase homology domain; Region: CHD; cd07302 378806018051 dimer interface [polypeptide binding]; other site 378806018052 nucleotidyl binding site; other site 378806018053 metal binding site [ion binding]; metal-binding site 378806018054 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 378806018055 Ferritin-like domain; Region: Ferritin; pfam00210 378806018056 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 378806018057 dimerization interface [polypeptide binding]; other site 378806018058 DPS ferroxidase diiron center [ion binding]; other site 378806018059 ion pore; other site 378806018060 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 378806018061 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 378806018062 C-terminal domain interface [polypeptide binding]; other site 378806018063 GSH binding site (G-site) [chemical binding]; other site 378806018064 dimer interface [polypeptide binding]; other site 378806018065 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 378806018066 dimer interface [polypeptide binding]; other site 378806018067 N-terminal domain interface [polypeptide binding]; other site 378806018068 putative substrate binding pocket (H-site) [chemical binding]; other site 378806018069 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 378806018070 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 378806018071 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 378806018072 dimer interface [polypeptide binding]; other site 378806018073 substrate binding site [chemical binding]; other site 378806018074 metal binding sites [ion binding]; metal-binding site 378806018075 CHAD domain; Region: CHAD; cl10506 378806018076 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 378806018077 CheB methylesterase; Region: CheB_methylest; pfam01339 378806018078 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 378806018079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806018080 PAS fold; Region: PAS_4; pfam08448 378806018081 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806018082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806018083 dimer interface [polypeptide binding]; other site 378806018084 phosphorylation site [posttranslational modification] 378806018085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806018086 ATP binding site [chemical binding]; other site 378806018087 Mg2+ binding site [ion binding]; other site 378806018088 G-X-G motif; other site 378806018089 Response regulator receiver domain; Region: Response_reg; pfam00072 378806018090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806018091 active site 378806018092 phosphorylation site [posttranslational modification] 378806018093 intermolecular recognition site; other site 378806018094 dimerization interface [polypeptide binding]; other site 378806018095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806018096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806018097 dimer interface [polypeptide binding]; other site 378806018098 phosphorylation site [posttranslational modification] 378806018099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806018100 ATP binding site [chemical binding]; other site 378806018101 Mg2+ binding site [ion binding]; other site 378806018102 G-X-G motif; other site 378806018103 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 378806018104 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 378806018105 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 378806018106 active site 378806018107 catalytic site [active] 378806018108 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 378806018109 catalytic residues [active] 378806018110 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 378806018111 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018112 active site 378806018113 ATP binding site [chemical binding]; other site 378806018114 substrate binding site [chemical binding]; other site 378806018115 activation loop (A-loop); other site 378806018116 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 378806018117 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 378806018118 ATP binding site [chemical binding]; other site 378806018119 Mg++ binding site [ion binding]; other site 378806018120 motif III; other site 378806018121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806018122 nucleotide binding region [chemical binding]; other site 378806018123 ATP-binding site [chemical binding]; other site 378806018124 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 378806018125 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 378806018126 putative dimer interface [polypeptide binding]; other site 378806018127 putative anticodon binding site; other site 378806018128 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 378806018129 homodimer interface [polypeptide binding]; other site 378806018130 motif 1; other site 378806018131 motif 2; other site 378806018132 active site 378806018133 motif 3; other site 378806018134 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806018135 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806018136 N-terminal plug; other site 378806018137 ligand-binding site [chemical binding]; other site 378806018138 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 378806018139 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806018140 ligand binding site [chemical binding]; other site 378806018141 Uncharacterized conserved protein [Function unknown]; Region: COG1912 378806018142 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 378806018143 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806018144 Putative serine esterase (DUF676); Region: DUF676; pfam05057 378806018145 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 378806018146 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 378806018147 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806018148 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806018149 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 378806018150 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 378806018151 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806018152 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 378806018153 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 378806018154 Walker A/P-loop; other site 378806018155 ATP binding site [chemical binding]; other site 378806018156 Q-loop/lid; other site 378806018157 ABC transporter signature motif; other site 378806018158 Walker B; other site 378806018159 D-loop; other site 378806018160 H-loop/switch region; other site 378806018161 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 378806018162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806018163 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 378806018164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 378806018165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806018166 dimer interface [polypeptide binding]; other site 378806018167 conserved gate region; other site 378806018168 putative PBP binding loops; other site 378806018169 ABC-ATPase subunit interface; other site 378806018170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 378806018171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806018172 dimer interface [polypeptide binding]; other site 378806018173 conserved gate region; other site 378806018174 putative PBP binding loops; other site 378806018175 ABC-ATPase subunit interface; other site 378806018176 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 378806018177 putative ligand binding site [chemical binding]; other site 378806018178 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 378806018179 Endonuclease I; Region: Endonuclease_1; cl01003 378806018180 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 378806018181 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 378806018182 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 378806018183 Ligand Binding Site [chemical binding]; other site 378806018184 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018185 active site 378806018186 ATP binding site [chemical binding]; other site 378806018187 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806018188 substrate binding site [chemical binding]; other site 378806018189 activation loop (A-loop); other site 378806018190 cyclase homology domain; Region: CHD; cd07302 378806018191 nucleotidyl binding site; other site 378806018192 metal binding site [ion binding]; metal-binding site 378806018193 dimer interface [polypeptide binding]; other site 378806018194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806018195 PAS domain S-box; Region: sensory_box; TIGR00229 378806018196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806018197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806018198 ATP binding site [chemical binding]; other site 378806018199 Mg2+ binding site [ion binding]; other site 378806018200 G-X-G motif; other site 378806018201 Response regulator receiver domain; Region: Response_reg; pfam00072 378806018202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806018203 active site 378806018204 phosphorylation site [posttranslational modification] 378806018205 intermolecular recognition site; other site 378806018206 dimerization interface [polypeptide binding]; other site 378806018207 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806018208 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 378806018209 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 378806018210 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 378806018211 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 378806018212 active site 378806018213 Zn binding site [ion binding]; other site 378806018214 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 378806018215 potential catalytic triad [active] 378806018216 conserved cys residue [active] 378806018217 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 378806018218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806018219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 378806018220 dimerization interface [polypeptide binding]; other site 378806018221 short chain dehydrogenase; Provisional; Region: PRK08278 378806018222 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 378806018223 NAD(P) binding site [chemical binding]; other site 378806018224 homodimer interface [polypeptide binding]; other site 378806018225 active site 378806018226 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018227 active site 378806018228 ATP binding site [chemical binding]; other site 378806018229 substrate binding site [chemical binding]; other site 378806018230 activation loop (A-loop); other site 378806018231 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 378806018232 active site 378806018233 zinc binding site [ion binding]; other site 378806018234 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 378806018235 nucleotide binding site [chemical binding]; other site 378806018236 substrate binding site [chemical binding]; other site 378806018237 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 378806018238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806018239 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 378806018240 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 378806018241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806018242 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 378806018243 endonuclease III; Region: ENDO3c; smart00478 378806018244 minor groove reading motif; other site 378806018245 helix-hairpin-helix signature motif; other site 378806018246 substrate binding pocket [chemical binding]; other site 378806018247 active site 378806018248 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 378806018249 putative active site [active] 378806018250 catalytic site [active] 378806018251 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 378806018252 putative active site [active] 378806018253 catalytic site [active] 378806018254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806018255 acyl-coenzyme A oxidase; Region: PLN02636 378806018256 active site 378806018257 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806018258 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 378806018259 oligomer interface [polypeptide binding]; other site 378806018260 active site residues [active] 378806018261 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 378806018262 putative active site [active] 378806018263 catalytic site [active] 378806018264 fumarate hydratase; Reviewed; Region: fumC; PRK00485 378806018265 Class II fumarases; Region: Fumarase_classII; cd01362 378806018266 active site 378806018267 tetramer interface [polypeptide binding]; other site 378806018268 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 378806018269 Peptidase family M48; Region: Peptidase_M48; cl12018 378806018270 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 378806018271 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806018272 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 378806018273 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 378806018274 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 378806018275 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806018276 phosphopeptide binding site; other site 378806018277 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 378806018278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806018279 Walker A motif; other site 378806018280 ATP binding site [chemical binding]; other site 378806018281 Walker B motif; other site 378806018282 arginine finger; other site 378806018283 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806018284 Protein kinase domain; Region: Pkinase; pfam00069 378806018285 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018286 active site 378806018287 ATP binding site [chemical binding]; other site 378806018288 substrate binding site [chemical binding]; other site 378806018289 activation loop (A-loop); other site 378806018290 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 378806018291 putative active site [active] 378806018292 PspC domain; Region: PspC; cl00864 378806018293 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 378806018294 malate synthase A; Region: malate_syn_A; TIGR01344 378806018295 active site 378806018296 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 378806018297 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 378806018298 tetramer interface [polypeptide binding]; other site 378806018299 active site 378806018300 Mg2+/Mn2+ binding site [ion binding]; other site 378806018301 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 378806018302 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 378806018303 B12 binding site [chemical binding]; other site 378806018304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806018305 FeS/SAM binding site; other site 378806018306 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 378806018307 putative active site [active] 378806018308 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806018309 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806018310 catalytic residue [active] 378806018311 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 378806018312 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 378806018313 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806018314 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806018315 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 378806018316 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 378806018317 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 378806018318 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018319 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806018320 active site 378806018321 ATP binding site [chemical binding]; other site 378806018322 substrate binding site [chemical binding]; other site 378806018323 activation loop (A-loop); other site 378806018324 Response regulator receiver domain; Region: Response_reg; pfam00072 378806018325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806018326 active site 378806018327 phosphorylation site [posttranslational modification] 378806018328 intermolecular recognition site; other site 378806018329 dimerization interface [polypeptide binding]; other site 378806018330 cyclase homology domain; Region: CHD; cd07302 378806018331 nucleotidyl binding site; other site 378806018332 metal binding site [ion binding]; metal-binding site 378806018333 dimer interface [polypeptide binding]; other site 378806018334 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806018335 phosphopeptide binding site; other site 378806018336 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806018337 GAF domain; Region: GAF; cl00853 378806018338 cyclase homology domain; Region: CHD; cd07302 378806018339 nucleotidyl binding site; other site 378806018340 metal binding site [ion binding]; metal-binding site 378806018341 dimer interface [polypeptide binding]; other site 378806018342 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806018343 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 378806018344 ligand binding site [chemical binding]; other site 378806018345 flexible hinge region; other site 378806018346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806018347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806018348 binding surface 378806018349 TPR motif; other site 378806018350 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806018351 ligand binding site [chemical binding]; other site 378806018352 flexible hinge region; other site 378806018353 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378806018354 ligand binding site [chemical binding]; other site 378806018355 flexible hinge region; other site 378806018356 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 378806018357 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 378806018358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806018359 dimer interface [polypeptide binding]; other site 378806018360 phosphorylation site [posttranslational modification] 378806018361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806018362 ATP binding site [chemical binding]; other site 378806018363 Mg2+ binding site [ion binding]; other site 378806018364 G-X-G motif; other site 378806018365 Response regulator receiver domain; Region: Response_reg; pfam00072 378806018366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806018367 active site 378806018368 phosphorylation site [posttranslational modification] 378806018369 intermolecular recognition site; other site 378806018370 dimerization interface [polypeptide binding]; other site 378806018371 Response regulator receiver domain; Region: Response_reg; pfam00072 378806018372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806018373 active site 378806018374 phosphorylation site [posttranslational modification] 378806018375 intermolecular recognition site; other site 378806018376 dimerization interface [polypeptide binding]; other site 378806018377 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806018378 GAF domain; Region: GAF; cl00853 378806018379 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806018380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806018381 FeS/SAM binding site; other site 378806018382 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 378806018383 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806018384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806018385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806018386 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 378806018387 active site 378806018388 DNA binding site [nucleotide binding] 378806018389 hypothetical protein; Provisional; Region: PRK08244 378806018390 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806018391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806018392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806018393 tetracycline repressor protein TetR; Provisional; Region: PRK13756 378806018394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806018395 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 378806018396 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 378806018397 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806018398 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 378806018399 Surface antigen; Region: Bac_surface_Ag; cl03097 378806018400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 378806018401 Family of unknown function (DUF490); Region: DUF490; pfam04357 378806018402 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 378806018403 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 378806018404 Domain of unknown function (DU1801); Region: DUF1801; cl01838 378806018405 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 378806018406 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 378806018407 metal ion-dependent adhesion site (MIDAS); other site 378806018408 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806018409 active site 378806018410 ATP binding site [chemical binding]; other site 378806018411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806018412 substrate binding site [chemical binding]; other site 378806018413 activation loop (A-loop); other site 378806018414 Aerotolerance regulator N-terminal; Region: BatA; cl06567 378806018415 Protein of unknown function DUF58; Region: DUF58; pfam01882 378806018416 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 378806018417 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 378806018418 Walker A/P-loop; other site 378806018419 ATP binding site [chemical binding]; other site 378806018420 Q-loop/lid; other site 378806018421 ABC transporter signature motif; other site 378806018422 Walker B; other site 378806018423 D-loop; other site 378806018424 H-loop/switch region; other site 378806018425 MoxR-like ATPases [General function prediction only]; Region: COG0714 378806018426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806018427 Walker A motif; other site 378806018428 ATP binding site [chemical binding]; other site 378806018429 Walker B motif; other site 378806018430 arginine finger; other site 378806018431 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 378806018432 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806018433 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806018434 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378806018435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806018436 Protein of unknown function, DUF547; Region: DUF547; pfam04784 378806018437 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378806018438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806018439 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 378806018440 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 378806018441 TM-ABC transporter signature motif; other site 378806018442 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 378806018443 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806018444 Walker A/P-loop; other site 378806018445 ATP binding site [chemical binding]; other site 378806018446 Q-loop/lid; other site 378806018447 ABC transporter signature motif; other site 378806018448 Walker B; other site 378806018449 D-loop; other site 378806018450 H-loop/switch region; other site 378806018451 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 378806018452 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 378806018453 putative ligand binding site [chemical binding]; other site 378806018454 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 378806018455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806018456 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806018457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806018458 NAD(P) binding site [chemical binding]; other site 378806018459 active site 378806018460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806018461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806018462 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 378806018463 putative effector binding pocket; other site 378806018464 dimerization interface [polypeptide binding]; other site 378806018465 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 378806018466 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806018467 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 378806018468 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 378806018469 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 378806018470 active site 378806018471 substrate binding site [chemical binding]; other site 378806018472 metal binding site [ion binding]; metal-binding site 378806018473 Glycine-rich protein domain (DUF2403); Region: DUF2403; pfam10290 378806018474 Putative TOS1-like glycosyl hydrolase (DUF2401); Region: DUF2401; pfam10287 378806018475 PAS domain S-box; Region: sensory_box; TIGR00229 378806018476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806018477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806018478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806018479 ATP binding site [chemical binding]; other site 378806018480 Mg2+ binding site [ion binding]; other site 378806018481 G-X-G motif; other site 378806018482 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806018483 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 378806018484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806018485 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 378806018486 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 378806018487 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 378806018488 homodimer interface [polypeptide binding]; other site 378806018489 substrate-cofactor binding pocket; other site 378806018490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806018491 catalytic residue [active] 378806018492 CotH protein; Region: CotH; pfam08757 378806018493 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 378806018494 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 378806018495 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 378806018496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 378806018497 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 378806018498 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018499 active site 378806018500 ATP binding site [chemical binding]; other site 378806018501 substrate binding site [chemical binding]; other site 378806018502 activation loop (A-loop); other site 378806018503 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806018504 Cytochrome P450; Region: p450; cl12078 378806018505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806018506 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 378806018507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806018508 dimer interface [polypeptide binding]; other site 378806018509 conserved gate region; other site 378806018510 putative PBP binding loops; other site 378806018511 ABC-ATPase subunit interface; other site 378806018512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806018513 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 378806018514 Walker A/P-loop; other site 378806018515 ATP binding site [chemical binding]; other site 378806018516 Q-loop/lid; other site 378806018517 ABC transporter signature motif; other site 378806018518 Walker B; other site 378806018519 D-loop; other site 378806018520 H-loop/switch region; other site 378806018521 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 378806018522 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 378806018523 Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559 378806018524 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806018525 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806018526 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 378806018527 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 378806018528 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806018529 sugar binding site [chemical binding]; other site 378806018530 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806018531 sugar binding site [chemical binding]; other site 378806018532 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806018533 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 378806018534 ATPase; Provisional; Region: PRK13764 378806018535 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 378806018536 G1 box; other site 378806018537 GTP/Mg2+ binding site [chemical binding]; other site 378806018538 Switch I region; other site 378806018539 G2 box; other site 378806018540 Switch II region; other site 378806018541 G3 box; other site 378806018542 G4 box; other site 378806018543 Domain of unknown function (DUF697); Region: DUF697; cl12064 378806018544 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018545 active site 378806018546 ATP binding site [chemical binding]; other site 378806018547 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806018548 substrate binding site [chemical binding]; other site 378806018549 activation loop (A-loop); other site 378806018550 Preprotein translocase subunit Sec63 [Intracellular trafficking and secretion]; Region: SEC63; COG5407 378806018551 Putative exonuclease, RdgC; Region: RdgC; cl01122 378806018552 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 378806018553 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 378806018554 YCII-related domain; Region: YCII; cl00999 378806018555 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 378806018556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806018557 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806018558 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 378806018559 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 378806018560 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 378806018561 active site 378806018562 HIGH motif; other site 378806018563 KMSK motif region; other site 378806018564 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 378806018565 tRNA binding surface [nucleotide binding]; other site 378806018566 anticodon binding site; other site 378806018567 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806018568 Putative esterase; Region: Esterase; pfam00756 378806018569 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806018570 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 378806018571 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 378806018572 Substrate binding site [chemical binding]; other site 378806018573 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 378806018574 active site 378806018575 oxyanion hole [active] 378806018576 catalytic triad [active] 378806018577 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 378806018578 active site 378806018579 catalytic triad [active] 378806018580 oxyanion hole [active] 378806018581 MBOAT family; Region: MBOAT; cl00738 378806018582 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 378806018583 putative active site [active] 378806018584 putative CoA binding site [chemical binding]; other site 378806018585 nudix motif; other site 378806018586 metal binding site [ion binding]; metal-binding site 378806018587 Bacitracin resistance protein BacA; Region: BacA; cl00858 378806018588 SEC-C motif; Region: SEC-C; cl12132 378806018589 hypothetical protein; Provisional; Region: PRK04233 378806018590 S-adenosylmethionine synthetase; Validated; Region: PRK05250 378806018591 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 378806018592 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 378806018593 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 378806018594 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 378806018595 Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389 378806018596 Site-specific recombinase; Region: SpecificRecomb; pfam10136 378806018597 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 378806018598 MgtC family; Region: MgtC; cl12207 378806018599 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 378806018600 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806018601 Walker A/P-loop; other site 378806018602 ATP binding site [chemical binding]; other site 378806018603 Q-loop/lid; other site 378806018604 ABC transporter signature motif; other site 378806018605 Walker B; other site 378806018606 D-loop; other site 378806018607 H-loop/switch region; other site 378806018608 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 378806018609 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806018610 N-terminal plug; other site 378806018611 ligand-binding site [chemical binding]; other site 378806018612 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 378806018613 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 378806018614 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 378806018615 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 378806018616 ChuX-like family; Region: DUF1008; cl01509 378806018617 ChuX-like family; Region: DUF1008; cl01509 378806018618 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 378806018619 intersubunit interface [polypeptide binding]; other site 378806018620 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 378806018621 dimer interface [polypeptide binding]; other site 378806018622 putative PBP binding regions; other site 378806018623 ABC-ATPase subunit interface; other site 378806018624 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 378806018625 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 378806018626 Walker A/P-loop; other site 378806018627 ATP binding site [chemical binding]; other site 378806018628 Q-loop/lid; other site 378806018629 ABC transporter signature motif; other site 378806018630 Walker B; other site 378806018631 D-loop; other site 378806018632 H-loop/switch region; other site 378806018633 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378806018634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806018635 CotH protein; Region: CotH; pfam08757 378806018636 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037 378806018637 ligand binding surface [chemical binding]; other site 378806018638 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 378806018639 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 378806018640 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 378806018641 homodimer interface [polypeptide binding]; other site 378806018642 NADP binding site [chemical binding]; other site 378806018643 substrate binding site [chemical binding]; other site 378806018644 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 378806018645 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 378806018646 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 378806018647 Putative ammonia monooxygenase; Region: AmoA; pfam05145 378806018648 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 378806018649 Protein kinase domain; Region: Pkinase; pfam00069 378806018650 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018651 active site 378806018652 ATP binding site [chemical binding]; other site 378806018653 substrate binding site [chemical binding]; other site 378806018654 activation loop (A-loop); other site 378806018655 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806018656 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806018657 substrate binding pocket [chemical binding]; other site 378806018658 catalytic triad [active] 378806018659 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806018660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806018661 DNA-binding site [nucleotide binding]; DNA binding site 378806018662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806018663 TPR motif; other site 378806018664 binding surface 378806018665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806018666 binding surface 378806018667 TPR motif; other site 378806018668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806018669 TPR motif; other site 378806018670 binding surface 378806018671 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806018672 potential frameshift: common BLAST hit: gi|108759376|ref|YP_631754.1| M36 family peptidase 378806018673 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 378806018674 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 378806018675 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 378806018676 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 378806018677 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 378806018678 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 378806018679 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 378806018680 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 378806018681 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 378806018682 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 378806018683 dimerization domain swap beta strand [polypeptide binding]; other site 378806018684 regulatory protein interface [polypeptide binding]; other site 378806018685 active site 378806018686 regulatory phosphorylation site [posttranslational modification]; other site 378806018687 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 378806018688 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 378806018689 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cl00021 378806018690 active site 378806018691 phosphorylation site [posttranslational modification] 378806018692 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 378806018693 active pocket/dimerization site; other site 378806018694 active site 378806018695 phosphorylation site [posttranslational modification] 378806018696 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 378806018697 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806018698 dimerization interface [polypeptide binding]; other site 378806018699 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 378806018700 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 378806018701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806018702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806018703 S-adenosylmethionine binding site [chemical binding]; other site 378806018704 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 378806018705 HPr kinase/phosphorylase; Provisional; Region: PRK05428 378806018706 DRTGG domain; Region: DRTGG; cl12147 378806018707 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 378806018708 Hpr binding site; other site 378806018709 active site 378806018710 homohexamer subunit interaction site [polypeptide binding]; other site 378806018711 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 378806018712 nucleotide binding site/active site [active] 378806018713 HIT family signature motif; other site 378806018714 catalytic residue [active] 378806018715 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 378806018716 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 378806018717 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 378806018718 Cl- selectivity filter; other site 378806018719 Cl- binding residues [ion binding]; other site 378806018720 pore gating glutamate residue; other site 378806018721 dimer interface [polypeptide binding]; other site 378806018722 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 378806018723 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 378806018724 Walker A/P-loop; other site 378806018725 ATP binding site [chemical binding]; other site 378806018726 Q-loop/lid; other site 378806018727 ABC transporter signature motif; other site 378806018728 Walker B; other site 378806018729 D-loop; other site 378806018730 H-loop/switch region; other site 378806018731 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806018732 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018733 active site 378806018734 ATP binding site [chemical binding]; other site 378806018735 substrate binding site [chemical binding]; other site 378806018736 activation loop (A-loop); other site 378806018737 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806018738 phosphopeptide binding site; other site 378806018739 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806018740 cyclase homology domain; Region: CHD; cd07302 378806018741 nucleotidyl binding site; other site 378806018742 metal binding site [ion binding]; metal-binding site 378806018743 dimer interface [polypeptide binding]; other site 378806018744 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 378806018745 Domain of unknown function (DU1801); Region: DUF1801; cl01838 378806018746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378806018747 dimerization interface [polypeptide binding]; other site 378806018748 putative DNA binding site [nucleotide binding]; other site 378806018749 putative Zn2+ binding site [ion binding]; other site 378806018750 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 378806018751 putative hydrophobic ligand binding site [chemical binding]; other site 378806018752 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806018753 Walker A/P-loop; other site 378806018754 ATP binding site [chemical binding]; other site 378806018755 Q-loop/lid; other site 378806018756 ABC transporter signature motif; other site 378806018757 Walker B; other site 378806018758 D-loop; other site 378806018759 H-loop/switch region; other site 378806018760 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 378806018761 putative transposase OrfB; Reviewed; Region: PHA02517 378806018762 Integrase core domain; Region: rve; cl01316 378806018763 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 378806018764 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806018765 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 378806018766 Transposase domain (DUF772); Region: DUF772; cl12084 378806018767 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806018768 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 378806018769 Integrase core domain; Region: rve; cl01316 378806018770 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 378806018771 Superfamily II helicase [General function prediction only]; Region: COG1204 378806018772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806018773 ATP binding site [chemical binding]; other site 378806018774 putative Mg++ binding site [ion binding]; other site 378806018775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806018776 nucleotide binding region [chemical binding]; other site 378806018777 ATP-binding site [chemical binding]; other site 378806018778 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 378806018779 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 378806018780 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 378806018781 putative C-terminal domain interface [polypeptide binding]; other site 378806018782 putative GSH binding site (G-site) [chemical binding]; other site 378806018783 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806018784 putative dimer interface [polypeptide binding]; other site 378806018785 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 378806018786 N-terminal domain interface [polypeptide binding]; other site 378806018787 dimer interface [polypeptide binding]; other site 378806018788 substrate binding pocket (H-site) [chemical binding]; other site 378806018789 Pectinacetylesterase; Region: PAE; pfam03283 378806018790 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 378806018791 Cadmium resistance transporter; Region: Cad; cl04177 378806018792 Vault protein inter-alpha-trypsin; Region: VIT; cl02699 378806018793 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 378806018794 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806018795 metal ion-dependent adhesion site (MIDAS); other site 378806018796 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 378806018797 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 378806018798 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 378806018799 ABC-ATPase subunit interface; other site 378806018800 dimer interface [polypeptide binding]; other site 378806018801 putative PBP binding regions; other site 378806018802 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 378806018803 intersubunit interface [polypeptide binding]; other site 378806018804 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 378806018805 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 378806018806 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 378806018807 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806018808 N-terminal plug; other site 378806018809 ligand-binding site [chemical binding]; other site 378806018810 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806018811 phosphopeptide binding site; other site 378806018812 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 378806018813 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 378806018814 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 378806018815 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378806018816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806018817 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806018818 Zn binding site [ion binding]; other site 378806018819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806018820 TPR motif; other site 378806018821 binding surface 378806018822 Membrane transport protein; Region: Mem_trans; cl09117 378806018823 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 378806018824 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 378806018825 catalytic residues [active] 378806018826 FRG domain; Region: FRG; pfam08867 378806018827 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 378806018828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806018829 DNA binding residues [nucleotide binding] 378806018830 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 378806018831 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 378806018832 MOSC domain; Region: MOSC; pfam03473 378806018833 Protein kinase domain; Region: Pkinase; pfam00069 378806018834 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018835 active site 378806018836 ATP binding site [chemical binding]; other site 378806018837 substrate binding site [chemical binding]; other site 378806018838 activation loop (A-loop); other site 378806018839 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806018840 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806018841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806018842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806018843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806018844 dimer interface [polypeptide binding]; other site 378806018845 phosphorylation site [posttranslational modification] 378806018846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806018847 ATP binding site [chemical binding]; other site 378806018848 Mg2+ binding site [ion binding]; other site 378806018849 G-X-G motif; other site 378806018850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806018851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806018852 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806018853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806018854 S-adenosylmethionine binding site [chemical binding]; other site 378806018855 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 378806018856 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 378806018857 DNA binding residues [nucleotide binding] 378806018858 putative dimer interface [polypeptide binding]; other site 378806018859 putative metal binding residues [ion binding]; other site 378806018860 tellurite resistance protein terB; Region: terB; cd07176 378806018861 putative metal binding site [ion binding]; other site 378806018862 Disintegrin; Region: Disintegrin; cl10507 378806018863 Disintegrin; Region: Disintegrin; cl10507 378806018864 Disintegrin; Region: Disintegrin; cl10507 378806018865 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 378806018866 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 378806018867 active site 378806018868 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 378806018869 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 378806018870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806018871 Protein kinase domain; Region: Pkinase; pfam00069 378806018872 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806018873 active site 378806018874 ATP binding site [chemical binding]; other site 378806018875 substrate binding site [chemical binding]; other site 378806018876 activation loop (A-loop); other site 378806018877 Predicted ATPase [General function prediction only]; Region: COG3899 378806018878 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806018879 GAF domain; Region: GAF; cl00853 378806018880 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806018881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806018882 ATP binding site [chemical binding]; other site 378806018883 Mg2+ binding site [ion binding]; other site 378806018884 G-X-G motif; other site 378806018885 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806018886 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 378806018887 Integrase core domain; Region: rve; cl01316 378806018888 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806018889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806018890 active site 378806018891 phosphorylation site [posttranslational modification] 378806018892 intermolecular recognition site; other site 378806018893 dimerization interface [polypeptide binding]; other site 378806018894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806018895 dimer interface [polypeptide binding]; other site 378806018896 phosphorylation site [posttranslational modification] 378806018897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806018898 ATP binding site [chemical binding]; other site 378806018899 Mg2+ binding site [ion binding]; other site 378806018900 G-X-G motif; other site 378806018901 Response regulator receiver domain; Region: Response_reg; pfam00072 378806018902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806018903 active site 378806018904 phosphorylation site [posttranslational modification] 378806018905 intermolecular recognition site; other site 378806018906 dimerization interface [polypeptide binding]; other site 378806018907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806018908 PAS fold; Region: PAS_3; pfam08447 378806018909 putative active site [active] 378806018910 heme pocket [chemical binding]; other site 378806018911 GAF domain; Region: GAF; cl00853 378806018912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806018913 putative active site [active] 378806018914 PAS fold; Region: PAS_3; pfam08447 378806018915 heme pocket [chemical binding]; other site 378806018916 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806018917 GAF domain; Region: GAF; cl00853 378806018918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806018919 dimer interface [polypeptide binding]; other site 378806018920 phosphorylation site [posttranslational modification] 378806018921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806018922 ATP binding site [chemical binding]; other site 378806018923 Mg2+ binding site [ion binding]; other site 378806018924 G-X-G motif; other site 378806018925 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 378806018926 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 378806018927 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 378806018928 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 378806018929 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806018930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806018931 active site 378806018932 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 378806018933 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 378806018934 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 378806018935 putative hydrophobic ligand binding site [chemical binding]; other site 378806018936 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378806018937 dimerization interface [polypeptide binding]; other site 378806018938 putative DNA binding site [nucleotide binding]; other site 378806018939 putative Zn2+ binding site [ion binding]; other site 378806018940 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 378806018941 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 378806018942 active site 378806018943 Zn binding site [ion binding]; other site 378806018944 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806018945 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 378806018946 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 378806018947 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806018948 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806018949 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806018950 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806018951 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806018952 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806018953 Uncharacterized conserved protein [Function unknown]; Region: COG4715 378806018954 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 378806018955 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378806018956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806018957 ATP binding site [chemical binding]; other site 378806018958 putative Mg++ binding site [ion binding]; other site 378806018959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806018960 nucleotide binding region [chemical binding]; other site 378806018961 ATP-binding site [chemical binding]; other site 378806018962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806018963 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 378806018964 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 378806018965 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 378806018966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806018967 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 378806018968 putative dimerization interface [polypeptide binding]; other site 378806018969 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 378806018970 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 378806018971 active site 378806018972 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 378806018973 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 378806018974 DNA binding residues [nucleotide binding] 378806018975 Vault protein inter-alpha-trypsin; Region: VIT; cl02699 378806018976 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 378806018977 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806018978 metal ion-dependent adhesion site (MIDAS); other site 378806018979 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 378806018980 putative active site [active] 378806018981 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 378806018982 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 378806018983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806018984 Walker A/P-loop; other site 378806018985 ATP binding site [chemical binding]; other site 378806018986 Q-loop/lid; other site 378806018987 ABC transporter signature motif; other site 378806018988 Walker B; other site 378806018989 D-loop; other site 378806018990 H-loop/switch region; other site 378806018991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806018992 dimer interface [polypeptide binding]; other site 378806018993 conserved gate region; other site 378806018994 putative PBP binding loops; other site 378806018995 ABC-ATPase subunit interface; other site 378806018996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 378806018997 dimer interface [polypeptide binding]; other site 378806018998 conserved gate region; other site 378806018999 putative PBP binding loops; other site 378806019000 ABC-ATPase subunit interface; other site 378806019001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806019002 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806019003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806019004 putative active site [active] 378806019005 heme pocket [chemical binding]; other site 378806019006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019007 dimer interface [polypeptide binding]; other site 378806019008 phosphorylation site [posttranslational modification] 378806019009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019010 ATP binding site [chemical binding]; other site 378806019011 Mg2+ binding site [ion binding]; other site 378806019012 G-X-G motif; other site 378806019013 DNA gyrase subunit A; Validated; Region: PRK05560 378806019014 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 378806019015 CAP-like domain; other site 378806019016 Active site [active] 378806019017 primary dimer interface [polypeptide binding]; other site 378806019018 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378806019019 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378806019020 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378806019021 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378806019022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806019023 TPR motif; other site 378806019024 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 378806019025 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 378806019026 active site 2 [active] 378806019027 active site 1 [active] 378806019028 Beta-lactamase; Region: Beta-lactamase; cl01009 378806019029 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 378806019030 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 378806019031 active site 378806019032 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378806019033 catalytic core [active] 378806019034 Protein of unknown function (DUF952); Region: DUF952; cl01393 378806019035 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 378806019036 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 378806019037 active site 378806019038 potential frameshift: common BLAST hit: gi|166368847|ref|YP_001661120.1| hyalin repeat-containing protein 378806019039 short chain dehydrogenase; Provisional; Region: PRK06139 378806019040 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 378806019041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806019042 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806019043 Walker A motif; other site 378806019044 ATP binding site [chemical binding]; other site 378806019045 Walker B motif; other site 378806019046 arginine finger; other site 378806019047 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806019048 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806019049 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 378806019050 active site residue [active] 378806019051 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 378806019052 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 378806019053 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 378806019054 Histidine kinase; Region: HisKA_3; pfam07730 378806019055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019056 ATP binding site [chemical binding]; other site 378806019057 Mg2+ binding site [ion binding]; other site 378806019058 G-X-G motif; other site 378806019059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378806019060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019061 active site 378806019062 phosphorylation site [posttranslational modification] 378806019063 intermolecular recognition site; other site 378806019064 dimerization interface [polypeptide binding]; other site 378806019065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806019066 DNA binding residues [nucleotide binding] 378806019067 dimerization interface [polypeptide binding]; other site 378806019068 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806019069 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806019070 calcium binding site 2 [ion binding]; other site 378806019071 active site 378806019072 catalytic triad [active] 378806019073 calcium binding site 1 [ion binding]; other site 378806019074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806019075 NAD(P) binding site [chemical binding]; other site 378806019076 active site 378806019077 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 378806019078 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 378806019079 Predicted membrane protein [Function unknown]; Region: COG4485 378806019080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806019081 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 378806019082 homotrimer interaction site [polypeptide binding]; other site 378806019083 putative active site [active] 378806019084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806019085 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806019086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806019087 active site 378806019088 catalytic tetrad [active] 378806019089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806019090 dimerization interface [polypeptide binding]; other site 378806019091 kelch-like protein; Provisional; Region: PHA03098 378806019092 Kelch motif; Region: Kelch_1; cl02701 378806019093 Kelch motif; Region: Kelch_1; cl02701 378806019094 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 378806019095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806019096 TPR motif; other site 378806019097 binding surface 378806019098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806019099 binding surface 378806019100 TPR motif; other site 378806019101 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 378806019102 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 378806019103 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 378806019104 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 378806019105 ATP binding site [chemical binding]; other site 378806019106 Walker A motif; other site 378806019107 hexamer interface [polypeptide binding]; other site 378806019108 Walker B motif; other site 378806019109 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019110 active site 378806019111 ATP binding site [chemical binding]; other site 378806019112 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806019113 substrate binding site [chemical binding]; other site 378806019114 activation loop (A-loop); other site 378806019115 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 378806019116 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 378806019117 FAD binding pocket [chemical binding]; other site 378806019118 conserved FAD binding motif [chemical binding]; other site 378806019119 phosphate binding motif [ion binding]; other site 378806019120 beta-alpha-beta structure motif; other site 378806019121 NAD binding pocket [chemical binding]; other site 378806019122 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806019123 structural tetrad; other site 378806019124 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806019125 structural tetrad; other site 378806019126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 378806019127 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 378806019128 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 378806019129 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 378806019130 putative ligand binding site [chemical binding]; other site 378806019131 Protein kinase domain; Region: Pkinase; pfam00069 378806019132 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019133 active site 378806019134 ATP binding site [chemical binding]; other site 378806019135 substrate binding site [chemical binding]; other site 378806019136 activation loop (A-loop); other site 378806019137 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 378806019138 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 378806019139 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806019140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019141 active site 378806019142 phosphorylation site [posttranslational modification] 378806019143 intermolecular recognition site; other site 378806019144 dimerization interface [polypeptide binding]; other site 378806019145 chaperone protein DnaJ; Provisional; Region: PRK10767 378806019146 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 378806019147 HSP70 interaction site [polypeptide binding]; other site 378806019148 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 378806019149 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 378806019150 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 378806019151 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 378806019152 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 378806019153 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806019154 Walker A/P-loop; other site 378806019155 ATP binding site [chemical binding]; other site 378806019156 Q-loop/lid; other site 378806019157 ABC transporter signature motif; other site 378806019158 Walker B; other site 378806019159 D-loop; other site 378806019160 H-loop/switch region; other site 378806019161 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019163 dimer interface [polypeptide binding]; other site 378806019164 phosphorylation site [posttranslational modification] 378806019165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019166 ATP binding site [chemical binding]; other site 378806019167 Mg2+ binding site [ion binding]; other site 378806019168 G-X-G motif; other site 378806019169 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 378806019170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806019171 motif II; other site 378806019172 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 378806019173 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 378806019174 Zn binding site [ion binding]; other site 378806019175 ATP-dependent helicase HepA; Validated; Region: PRK04914 378806019176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806019177 ATP binding site [chemical binding]; other site 378806019178 putative Mg++ binding site [ion binding]; other site 378806019179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806019180 nucleotide binding region [chemical binding]; other site 378806019181 ATP-binding site [chemical binding]; other site 378806019182 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806019183 GAF domain; Region: GAF; cl00853 378806019184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806019185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019186 ATP binding site [chemical binding]; other site 378806019187 Mg2+ binding site [ion binding]; other site 378806019188 G-X-G motif; other site 378806019189 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 378806019190 heme-binding residues [chemical binding]; other site 378806019191 Uncharacterized conserved protein [Function unknown]; Region: COG3287 378806019192 FIST N domain; Region: FIST; pfam08495 378806019193 FIST C domain; Region: FIST_C; pfam10442 378806019194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378806019195 PAS fold; Region: PAS_4; pfam08448 378806019196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019197 dimer interface [polypeptide binding]; other site 378806019198 phosphorylation site [posttranslational modification] 378806019199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019200 ATP binding site [chemical binding]; other site 378806019201 Mg2+ binding site [ion binding]; other site 378806019202 G-X-G motif; other site 378806019203 Response regulator receiver domain; Region: Response_reg; pfam00072 378806019204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019205 active site 378806019206 phosphorylation site [posttranslational modification] 378806019207 intermolecular recognition site; other site 378806019208 dimerization interface [polypeptide binding]; other site 378806019209 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806019210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019211 active site 378806019212 phosphorylation site [posttranslational modification] 378806019213 intermolecular recognition site; other site 378806019214 Response regulator receiver domain; Region: Response_reg; pfam00072 378806019215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019216 active site 378806019217 phosphorylation site [posttranslational modification] 378806019218 intermolecular recognition site; other site 378806019219 dimerization interface [polypeptide binding]; other site 378806019220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019221 active site 378806019222 phosphorylation site [posttranslational modification] 378806019223 intermolecular recognition site; other site 378806019224 dimerization interface [polypeptide binding]; other site 378806019225 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 378806019226 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 378806019227 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378806019228 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378806019229 catalytic residue [active] 378806019230 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 378806019231 O-methyltransferase; Region: Methyltransf_2; pfam00891 378806019232 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378806019233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019234 active site 378806019235 phosphorylation site [posttranslational modification] 378806019236 intermolecular recognition site; other site 378806019237 dimerization interface [polypeptide binding]; other site 378806019238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806019239 DNA binding residues [nucleotide binding] 378806019240 dimerization interface [polypeptide binding]; other site 378806019241 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 378806019242 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 378806019243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806019244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806019245 PAS fold; Region: PAS_4; pfam08448 378806019246 PAS fold; Region: PAS; pfam00989 378806019247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806019248 putative active site [active] 378806019249 heme pocket [chemical binding]; other site 378806019250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019251 dimer interface [polypeptide binding]; other site 378806019252 phosphorylation site [posttranslational modification] 378806019253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019254 ATP binding site [chemical binding]; other site 378806019255 Mg2+ binding site [ion binding]; other site 378806019256 G-X-G motif; other site 378806019257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019258 active site 378806019259 phosphorylation site [posttranslational modification] 378806019260 intermolecular recognition site; other site 378806019261 CheB methylesterase; Region: CheB_methylest; pfam01339 378806019262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019263 active site 378806019264 phosphorylation site [posttranslational modification] 378806019265 intermolecular recognition site; other site 378806019266 dimerization interface [polypeptide binding]; other site 378806019267 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806019268 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019269 active site 378806019270 ATP binding site [chemical binding]; other site 378806019271 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806019272 substrate binding site [chemical binding]; other site 378806019273 activation loop (A-loop); other site 378806019274 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806019275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 378806019276 Response regulator receiver domain; Region: Response_reg; pfam00072 378806019277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019278 active site 378806019279 phosphorylation site [posttranslational modification] 378806019280 intermolecular recognition site; other site 378806019281 dimerization interface [polypeptide binding]; other site 378806019282 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806019283 PAS fold; Region: PAS; pfam00989 378806019284 GAF domain; Region: GAF; cl00853 378806019285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019286 dimer interface [polypeptide binding]; other site 378806019287 phosphorylation site [posttranslational modification] 378806019288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019289 ATP binding site [chemical binding]; other site 378806019290 Mg2+ binding site [ion binding]; other site 378806019291 G-X-G motif; other site 378806019292 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806019293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019294 active site 378806019295 phosphorylation site [posttranslational modification] 378806019296 intermolecular recognition site; other site 378806019297 dimerization interface [polypeptide binding]; other site 378806019298 Response regulator receiver domain; Region: Response_reg; pfam00072 378806019299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019300 active site 378806019301 phosphorylation site [posttranslational modification] 378806019302 intermolecular recognition site; other site 378806019303 dimerization interface [polypeptide binding]; other site 378806019304 CheB methylesterase; Region: CheB_methylest; pfam01339 378806019305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806019306 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019307 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019308 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019309 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019310 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019311 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019312 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019313 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019314 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019315 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019316 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 378806019317 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806019318 GAF domain; Region: GAF; cl00853 378806019319 phosphodiesterase; Provisional; Region: PRK12704 378806019320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019321 dimer interface [polypeptide binding]; other site 378806019322 phosphorylation site [posttranslational modification] 378806019323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019324 ATP binding site [chemical binding]; other site 378806019325 Mg2+ binding site [ion binding]; other site 378806019326 G-X-G motif; other site 378806019327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806019328 active site 378806019329 phosphorylation site [posttranslational modification] 378806019330 intermolecular recognition site; other site 378806019331 dimerization interface [polypeptide binding]; other site 378806019332 Response regulator receiver domain; Region: Response_reg; pfam00072 378806019333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019334 active site 378806019335 phosphorylation site [posttranslational modification] 378806019336 intermolecular recognition site; other site 378806019337 dimerization interface [polypeptide binding]; other site 378806019338 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806019339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806019340 DNA-binding site [nucleotide binding]; DNA binding site 378806019341 Atrophin-1 family; Region: Atrophin-1; pfam03154 378806019342 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 378806019343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378806019344 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 378806019345 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 378806019346 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 378806019347 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 378806019348 DNA-binding site [nucleotide binding]; DNA binding site 378806019349 RNA-binding motif; other site 378806019350 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 378806019351 anti sigma factor interaction site; other site 378806019352 regulatory phosphorylation site [posttranslational modification]; other site 378806019353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806019354 Domain of unknown function DUF11; Region: DUF11; cl03172 378806019355 Domain of unknown function DUF11; Region: DUF11; cl03172 378806019356 Predicted transcriptional regulator [Transcription]; Region: COG1959 378806019357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806019358 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 378806019359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806019360 Protein kinase domain; Region: Pkinase; pfam00069 378806019361 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019362 active site 378806019363 ATP binding site [chemical binding]; other site 378806019364 substrate binding site [chemical binding]; other site 378806019365 activation loop (A-loop); other site 378806019366 Protein kinase domain; Region: Pkinase; pfam00069 378806019367 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019368 active site 378806019369 ATP binding site [chemical binding]; other site 378806019370 substrate binding site [chemical binding]; other site 378806019371 activation loop (A-loop); other site 378806019372 GAF domain; Region: GAF; cl00853 378806019373 PAS domain S-box; Region: sensory_box; TIGR00229 378806019374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806019375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806019376 putative active site [active] 378806019377 PAS fold; Region: PAS_3; pfam08447 378806019378 heme pocket [chemical binding]; other site 378806019379 PAS fold; Region: PAS_4; pfam08448 378806019380 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806019381 GAF domain; Region: GAF; cl00853 378806019382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019383 dimer interface [polypeptide binding]; other site 378806019384 phosphorylation site [posttranslational modification] 378806019385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019386 ATP binding site [chemical binding]; other site 378806019387 Mg2+ binding site [ion binding]; other site 378806019388 G-X-G motif; other site 378806019389 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 378806019390 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 378806019391 dimerization interface [polypeptide binding]; other site 378806019392 ATP binding site [chemical binding]; other site 378806019393 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 378806019394 dimerization interface [polypeptide binding]; other site 378806019395 ATP binding site [chemical binding]; other site 378806019396 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 378806019397 putative active site [active] 378806019398 catalytic triad [active] 378806019399 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 378806019400 active site 378806019401 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 378806019402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806019403 Rhomboid family; Region: Rhomboid; cl11446 378806019404 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 378806019405 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 378806019406 active site 378806019407 PEGA domain; Region: PEGA; pfam08308 378806019408 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 378806019409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806019410 Walker A motif; other site 378806019411 ATP binding site [chemical binding]; other site 378806019412 Walker B motif; other site 378806019413 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806019414 cleavage site 378806019415 active site 378806019416 substrate binding sites [chemical binding]; other site 378806019417 Beta-lactamase; Region: Beta-lactamase; cl01009 378806019418 OsmC-like protein; Region: OsmC; cl00767 378806019419 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 378806019420 catalytic triad [active] 378806019421 active site 378806019422 oxyanion hole [active] 378806019423 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 378806019424 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 378806019425 putative active site [active] 378806019426 catalytic triad [active] 378806019427 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378806019428 catalytic core [active] 378806019429 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 378806019430 Beta-lactamase; Region: Beta-lactamase; cl01009 378806019431 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 378806019432 amphipathic channel; other site 378806019433 Asn-Pro-Ala signature motifs; other site 378806019434 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 378806019435 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 378806019436 active site 378806019437 Double zinc ribbon; Region: DZR; pfam12773 378806019438 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806019439 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 378806019440 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 378806019441 GON domain; Region: GON; pfam08685 378806019442 GON domain; Region: GON; pfam08685 378806019443 Protein kinase domain; Region: Pkinase; pfam00069 378806019444 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806019445 active site 378806019446 substrate binding site [chemical binding]; other site 378806019447 activation loop (A-loop); other site 378806019448 Predicted ATPase [General function prediction only]; Region: COG3899 378806019449 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806019450 GAF domain; Region: GAF; cl00853 378806019451 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806019452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019453 ATP binding site [chemical binding]; other site 378806019454 Mg2+ binding site [ion binding]; other site 378806019455 G-X-G motif; other site 378806019456 Beta-lactamase; Region: Beta-lactamase; cl01009 378806019457 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806019458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 378806019459 The Bacteroides thetaiotaomicron protein represented by pdb structure 3CO4 is an uncharacterized bacterial member of the family 18 glycosyl hydrolases with homologs found in Flavobacterium, Stigmatella, and Pseudomonas; Region: GH18_3CO4_chitinase; cd06545 378806019460 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 378806019461 putative active site [active] 378806019462 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806019463 Alginate lyase; Region: Alginate_lyase2; pfam08787 378806019464 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806019465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806019466 DNA-binding site [nucleotide binding]; DNA binding site 378806019467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806019468 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 378806019469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806019470 FeS/SAM binding site; other site 378806019471 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806019472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806019473 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 378806019474 Uncharacterized conserved protein [Function unknown]; Region: COG4938 378806019475 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806019476 Walker A/P-loop; other site 378806019477 ATP binding site [chemical binding]; other site 378806019478 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 378806019479 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019480 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019481 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019482 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019483 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019484 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019485 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019486 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019487 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019488 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019489 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806019490 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019491 active site 378806019492 ATP binding site [chemical binding]; other site 378806019493 substrate binding site [chemical binding]; other site 378806019494 activation loop (A-loop); other site 378806019495 Domain of unknown function (DU1801); Region: DUF1801; cl01838 378806019496 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806019497 phosphopeptide binding site; other site 378806019498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 378806019499 I-site; other site 378806019500 active site 378806019501 metal binding site [ion binding]; metal-binding site 378806019502 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806019503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806019504 Walker A motif; other site 378806019505 ATP binding site [chemical binding]; other site 378806019506 Walker B motif; other site 378806019507 arginine finger; other site 378806019508 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806019509 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 378806019510 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806019511 active site 378806019512 ATP binding site [chemical binding]; other site 378806019513 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806019514 substrate binding site [chemical binding]; other site 378806019515 activation loop (A-loop); other site 378806019516 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806019517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806019518 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 378806019519 Walker A motif; other site 378806019520 ATP binding site [chemical binding]; other site 378806019521 Walker B motif; other site 378806019522 arginine finger; other site 378806019523 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806019524 putative catalytic site [active] 378806019525 putative metal binding site [ion binding]; other site 378806019526 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806019527 putative catalytic site [active] 378806019528 putative phosphate binding site [ion binding]; other site 378806019529 putative phosphate binding site [ion binding]; other site 378806019530 putative metal binding site [ion binding]; other site 378806019531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806019532 PAS fold; Region: PAS; pfam00989 378806019533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 378806019534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019535 dimer interface [polypeptide binding]; other site 378806019536 phosphorylation site [posttranslational modification] 378806019537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019538 ATP binding site [chemical binding]; other site 378806019539 Mg2+ binding site [ion binding]; other site 378806019540 G-X-G motif; other site 378806019541 TspO/MBR family; Region: TspO_MBR; cl01379 378806019542 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 378806019543 dinuclear metal binding motif [ion binding]; other site 378806019544 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 378806019545 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 378806019546 P loop; other site 378806019547 Nucleotide binding site [chemical binding]; other site 378806019548 DTAP/Switch II; other site 378806019549 Switch I; other site 378806019550 Rubredoxin [Energy production and conversion]; Region: COG1773 378806019551 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 378806019552 iron binding site [ion binding]; other site 378806019553 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 378806019554 Uncharacterized conserved protein [Function unknown]; Region: COG4748 378806019555 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 378806019556 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 378806019557 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 378806019558 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 378806019559 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 378806019560 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 378806019561 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806019562 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806019563 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806019564 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806019565 Myxococcus xanthus paralogous lipoprotein family TIGR02269; Region: TIGR02269 378806019566 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 378806019567 DNA-binding site [nucleotide binding]; DNA binding site 378806019568 RNA-binding motif; other site 378806019569 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 378806019570 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 378806019571 Protein kinase domain; Region: Pkinase; pfam00069 378806019572 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019573 active site 378806019574 ATP binding site [chemical binding]; other site 378806019575 substrate binding site [chemical binding]; other site 378806019576 activation loop (A-loop); other site 378806019577 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 378806019578 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 378806019579 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 378806019580 catalytic residues [active] 378806019581 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 378806019582 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 378806019583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806019584 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378806019585 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 378806019586 active site 378806019587 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 378806019588 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 378806019589 putative active site [active] 378806019590 putative NTP binding site [chemical binding]; other site 378806019591 putative nucleic acid binding site [nucleotide binding]; other site 378806019592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806019593 S-adenosylmethionine binding site [chemical binding]; other site 378806019594 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806019595 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 378806019596 Fatty acid desaturase; Region: FA_desaturase; pfam00487 378806019597 putative di-iron ligands [ion binding]; other site 378806019598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378806019599 metabolite-proton symporter; Region: 2A0106; TIGR00883 378806019600 putative substrate translocation pore; other site 378806019601 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 378806019602 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 378806019603 active sites [active] 378806019604 tetramer interface [polypeptide binding]; other site 378806019605 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 378806019606 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806019607 translocation protein TolB; Provisional; Region: tolB; PRK01742 378806019608 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 378806019609 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 378806019610 HSP70 interaction site [polypeptide binding]; other site 378806019611 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 378806019612 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 378806019613 Peptidase M14-like domain of an uncharacterized group of Peptidase M14 Carboxypeptidase (CP) T (CPT)-like proteins. This group belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-...; Region: M14_CPT_like; cd06226 378806019614 putative active site [active] 378806019615 Zn-binding site [ion binding]; other site 378806019616 Kelch motif; Region: Kelch_1; cl02701 378806019617 Kelch motif; Region: Kelch_1; cl02701 378806019618 kelch-like protein; Provisional; Region: PHA03098 378806019619 Kelch motif; Region: Kelch_1; cl02701 378806019620 Kelch motif; Region: Kelch_1; cl02701 378806019621 REJ domain; Region: REJ; pfam02010 378806019622 Kelch motif; Region: Kelch_1; cl02701 378806019623 Kelch motif; Region: Kelch_1; cl02701 378806019624 Kelch motif; Region: Kelch_1; cl02701 378806019625 Kelch motif; Region: Kelch_1; cl02701 378806019626 Kelch motif; Region: Kelch_1; cl02701 378806019627 Kelch motif; Region: Kelch_1; cl02701 378806019628 CHAT domain; Region: CHAT; cl02083 378806019629 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 378806019630 Peptidase family M23; Region: Peptidase_M23; pfam01551 378806019631 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 378806019632 N-terminal domain interface [polypeptide binding]; other site 378806019633 dimer interface [polypeptide binding]; other site 378806019634 substrate binding pocket (H-site) [chemical binding]; other site 378806019635 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 378806019636 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 378806019637 putative binding site; other site 378806019638 malonyl-CoA synthase; Validated; Region: PRK07514 378806019639 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806019640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806019641 DNA binding residues [nucleotide binding] 378806019642 dimerization interface [polypeptide binding]; other site 378806019643 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019644 active site 378806019645 ATP binding site [chemical binding]; other site 378806019646 substrate binding site [chemical binding]; other site 378806019647 activation loop (A-loop); other site 378806019648 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806019649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806019650 TPR motif; other site 378806019651 binding surface 378806019652 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806019653 phosphopeptide binding site; other site 378806019654 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806019655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806019656 Walker A motif; other site 378806019657 ATP binding site [chemical binding]; other site 378806019658 Walker B motif; other site 378806019659 arginine finger; other site 378806019660 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806019661 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 378806019662 putative active site [active] 378806019663 Isochorismatase family; Region: Isochorismatase; pfam00857 378806019664 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 378806019665 catalytic triad [active] 378806019666 dimer interface [polypeptide binding]; other site 378806019667 conserved cis-peptide bond; other site 378806019668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806019669 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 378806019670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806019671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806019672 Beta-lactamase; Region: Beta-lactamase; cl01009 378806019673 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806019674 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806019675 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 378806019676 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 378806019677 C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Alpha-MTH, also known as maltotetraose-forming exo-amylase or G4-amylase, is an exo-amylase found in bacteria that degrades starch from its non-reducing end. Most alpha-MTHs have, in...; Region: CBM20_alpha_MTH; cd05810 378806019678 starch-binding site 2 [chemical binding]; other site 378806019679 starch-binding site 1 [chemical binding]; other site 378806019680 Cupin domain; Region: Cupin_2; cl09118 378806019681 LysR family transcriptional regulator; Provisional; Region: PRK14997 378806019682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806019683 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 378806019684 putative effector binding pocket; other site 378806019685 dimerization interface [polypeptide binding]; other site 378806019686 YceI-like domain; Region: YceI; cl01001 378806019687 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 378806019688 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019689 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019690 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019691 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 378806019692 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019693 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806019694 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 378806019695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806019696 Walker A motif; other site 378806019697 ATP binding site [chemical binding]; other site 378806019698 Walker B motif; other site 378806019699 arginine finger; other site 378806019700 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806019701 Pirin-related protein [General function prediction only]; Region: COG1741 378806019702 Cupin domain; Region: Cupin_2; cl09118 378806019703 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 378806019704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806019705 non-specific DNA binding site [nucleotide binding]; other site 378806019706 salt bridge; other site 378806019707 sequence-specific DNA binding site [nucleotide binding]; other site 378806019708 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 378806019709 putative di-iron ligands [ion binding]; other site 378806019710 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 378806019711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806019712 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 378806019713 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 378806019714 putative C-terminal domain interface [polypeptide binding]; other site 378806019715 putative GSH binding site (G-site) [chemical binding]; other site 378806019716 putative dimer interface [polypeptide binding]; other site 378806019717 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 378806019718 N-terminal domain interface [polypeptide binding]; other site 378806019719 dimer interface [polypeptide binding]; other site 378806019720 substrate binding pocket (H-site) [chemical binding]; other site 378806019721 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 378806019722 putative active site [active] 378806019723 catalytic site [active] 378806019724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806019725 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 378806019726 NAD(P) binding site [chemical binding]; other site 378806019727 catalytic residues [active] 378806019728 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 378806019729 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806019730 NAD(P) binding site [chemical binding]; other site 378806019731 catalytic residues [active] 378806019732 B3/4 domain; Region: B3_4; cl11458 378806019733 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 378806019734 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 378806019735 ATP-binding site [chemical binding]; other site 378806019736 Gluconate-6-phosphate binding site [chemical binding]; other site 378806019737 PAS domain S-box; Region: sensory_box; TIGR00229 378806019738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806019739 GAF domain; Region: GAF; cl00853 378806019740 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806019741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019742 dimer interface [polypeptide binding]; other site 378806019743 phosphorylation site [posttranslational modification] 378806019744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019745 ATP binding site [chemical binding]; other site 378806019746 Mg2+ binding site [ion binding]; other site 378806019747 G-X-G motif; other site 378806019748 Response regulator receiver domain; Region: Response_reg; pfam00072 378806019749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019750 active site 378806019751 phosphorylation site [posttranslational modification] 378806019752 intermolecular recognition site; other site 378806019753 dimerization interface [polypeptide binding]; other site 378806019754 GAF domain; Region: GAF; cl00853 378806019755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019756 dimer interface [polypeptide binding]; other site 378806019757 phosphorylation site [posttranslational modification] 378806019758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019759 ATP binding site [chemical binding]; other site 378806019760 Mg2+ binding site [ion binding]; other site 378806019761 G-X-G motif; other site 378806019762 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 378806019763 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 378806019764 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 378806019765 active site 378806019766 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378806019767 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 378806019768 NAD(P) binding site [chemical binding]; other site 378806019769 catalytic residues [active] 378806019770 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 378806019771 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 378806019772 MatE; Region: MatE; pfam01554 378806019773 MatE; Region: MatE; pfam01554 378806019774 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 378806019775 Mechanosensitive ion channel; Region: MS_channel; pfam00924 378806019776 CHASE domain; Region: CHASE; cl01369 378806019777 PAS fold; Region: PAS_4; pfam08448 378806019778 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806019779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806019780 putative active site [active] 378806019781 heme pocket [chemical binding]; other site 378806019782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019783 dimer interface [polypeptide binding]; other site 378806019784 phosphorylation site [posttranslational modification] 378806019785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019786 ATP binding site [chemical binding]; other site 378806019787 Mg2+ binding site [ion binding]; other site 378806019788 G-X-G motif; other site 378806019789 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019790 active site 378806019791 ATP binding site [chemical binding]; other site 378806019792 substrate binding site [chemical binding]; other site 378806019793 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806019794 activation loop (A-loop); other site 378806019795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806019796 translation initiation factor IF-3; Region: infC; TIGR00168 378806019797 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 378806019798 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 378806019799 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 378806019800 Uncharacterized conserved protein [Function unknown]; Region: COG3391 378806019801 NHL repeat; Region: NHL; pfam01436 378806019802 Uncharacterized conserved protein [Function unknown]; Region: COG3391 378806019803 Uncharacterized conserved protein [Function unknown]; Region: COG3391 378806019804 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 378806019805 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 378806019806 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 378806019807 Stage II sporulation protein; Region: SpoIID; cl07201 378806019808 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 378806019809 MG2 domain; Region: A2M_N; pfam01835 378806019810 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 378806019811 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 378806019812 Alpha-2-macroglobulin family; Region: A2M; pfam00207 378806019813 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 378806019814 surface patch; other site 378806019815 thioester region; other site 378806019816 specificity defining residues; other site 378806019817 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 378806019818 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; cl01910 378806019819 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806019820 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 378806019821 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 378806019822 dimerization interface [polypeptide binding]; other site 378806019823 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806019824 GAF domain; Region: GAF; cl00853 378806019825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806019826 dimer interface [polypeptide binding]; other site 378806019827 phosphorylation site [posttranslational modification] 378806019828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019829 ATP binding site [chemical binding]; other site 378806019830 Mg2+ binding site [ion binding]; other site 378806019831 G-X-G motif; other site 378806019832 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806019833 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 378806019834 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 378806019835 active site 378806019836 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806019837 Putative esterase; Region: Esterase; pfam00756 378806019838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806019839 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 378806019840 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806019841 Predicted ATPase [General function prediction only]; Region: COG4637 378806019842 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806019843 Walker A/P-loop; other site 378806019844 ATP binding site [chemical binding]; other site 378806019845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806019846 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 378806019847 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806019848 Walker A/P-loop; other site 378806019849 ATP binding site [chemical binding]; other site 378806019850 Q-loop/lid; other site 378806019851 ABC transporter signature motif; other site 378806019852 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806019853 ABC transporter; Region: ABC_tran_2; pfam12848 378806019854 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 378806019855 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378806019856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806019857 Walker A/P-loop; other site 378806019858 ATP binding site [chemical binding]; other site 378806019859 Q-loop/lid; other site 378806019860 ABC transporter signature motif; other site 378806019861 Walker B; other site 378806019862 D-loop; other site 378806019863 H-loop/switch region; other site 378806019864 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806019865 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806019866 Protein kinase domain; Region: Pkinase; pfam00069 378806019867 active site 378806019868 ATP binding site [chemical binding]; other site 378806019869 substrate binding site [chemical binding]; other site 378806019870 activation loop (A-loop); other site 378806019871 PEGA domain; Region: PEGA; pfam08308 378806019872 PAS fold; Region: PAS_4; pfam08448 378806019873 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806019874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806019875 ATP binding site [chemical binding]; other site 378806019876 Mg2+ binding site [ion binding]; other site 378806019877 G-X-G motif; other site 378806019878 Response regulator receiver domain; Region: Response_reg; pfam00072 378806019879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019880 active site 378806019881 phosphorylation site [posttranslational modification] 378806019882 intermolecular recognition site; other site 378806019883 dimerization interface [polypeptide binding]; other site 378806019884 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 378806019885 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 378806019886 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806019887 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 378806019888 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806019889 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378806019890 YhhN-like protein; Region: YhhN; cl01505 378806019891 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 378806019892 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806019893 active site 378806019894 ATP binding site [chemical binding]; other site 378806019895 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806019896 substrate binding site [chemical binding]; other site 378806019897 activation loop (A-loop); other site 378806019898 Predicted ATPase [General function prediction only]; Region: COG3899 378806019899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019900 active site 378806019901 ATP binding site [chemical binding]; other site 378806019902 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806019903 substrate binding site [chemical binding]; other site 378806019904 activation loop (A-loop); other site 378806019905 Integrase core domain; Region: rve; cl01316 378806019906 Integrase core domain; Region: rve; cl01316 378806019907 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 378806019908 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 378806019909 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 378806019910 active site 378806019911 putative interdomain interaction site [polypeptide binding]; other site 378806019912 putative metal-binding site [ion binding]; other site 378806019913 putative nucleotide binding site [chemical binding]; other site 378806019914 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 378806019915 domain I; other site 378806019916 phosphate binding site [ion binding]; other site 378806019917 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 378806019918 domain II; other site 378806019919 domain III; other site 378806019920 nucleotide binding site [chemical binding]; other site 378806019921 DNA binding groove [nucleotide binding] 378806019922 catalytic site [active] 378806019923 domain IV; other site 378806019924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806019925 ATP binding site [chemical binding]; other site 378806019926 putative Mg++ binding site [ion binding]; other site 378806019927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806019928 nucleotide binding region [chemical binding]; other site 378806019929 ATP-binding site [chemical binding]; other site 378806019930 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 378806019931 HRDC domain; Region: HRDC; cl02578 378806019932 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378806019933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806019934 NAD(P) binding site [chemical binding]; other site 378806019935 active site 378806019936 TLC ATP/ADP transporter; Region: TLC; cl03940 378806019937 aspartate aminotransferase; Provisional; Region: PRK08361 378806019938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378806019939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806019940 homodimer interface [polypeptide binding]; other site 378806019941 catalytic residue [active] 378806019942 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 378806019943 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 378806019944 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 378806019945 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806019946 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806019947 active site 378806019948 ATP binding site [chemical binding]; other site 378806019949 substrate binding site [chemical binding]; other site 378806019950 activation loop (A-loop); other site 378806019951 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 378806019952 Response regulator receiver domain; Region: Response_reg; pfam00072 378806019953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806019954 active site 378806019955 phosphorylation site [posttranslational modification] 378806019956 intermolecular recognition site; other site 378806019957 dimerization interface [polypeptide binding]; other site 378806019958 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 378806019959 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 378806019960 nucleotide binding site/active site [active] 378806019961 HIT family signature motif; other site 378806019962 catalytic residue [active] 378806019963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806019964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806019965 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 378806019966 NAD(P) binding site [chemical binding]; other site 378806019967 active site 378806019968 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 378806019969 classical (c) SDRs; Region: SDR_c; cd05233 378806019970 NAD(P) binding site [chemical binding]; other site 378806019971 active site 378806019972 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 378806019973 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 378806019974 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 378806019975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806019976 binding surface 378806019977 TPR motif; other site 378806019978 PEGA domain; Region: PEGA; pfam08308 378806019979 PEGA domain; Region: PEGA; pfam08308 378806019980 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 378806019981 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806019982 N-terminal plug; other site 378806019983 ligand-binding site [chemical binding]; other site 378806019984 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 378806019985 nudix motif; other site 378806019986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806019987 Coenzyme A binding pocket [chemical binding]; other site 378806019988 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 378806019989 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 378806019990 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 378806019991 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 378806019992 nudix motif; other site 378806019993 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378806019994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806019995 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 378806019996 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 378806019997 Scramblase; Region: Scramblase; cl02043 378806019998 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 378806019999 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020000 active site 378806020001 ATP binding site [chemical binding]; other site 378806020002 substrate binding site [chemical binding]; other site 378806020003 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806020004 activation loop (A-loop); other site 378806020005 Integrase core domain; Region: rve; cl01316 378806020006 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 378806020007 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 378806020008 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806020009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806020010 DNA-binding site [nucleotide binding]; DNA binding site 378806020011 TIR domain; Region: TIR; cl02060 378806020012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806020013 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806020014 FOG: WD40 repeat [General function prediction only]; Region: COG2319 378806020015 structural tetrad; other site 378806020016 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806020017 structural tetrad; other site 378806020018 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806020019 structural tetrad; other site 378806020020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806020021 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 378806020022 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378806020023 active site 378806020024 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 378806020025 DXD motif; other site 378806020026 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 378806020027 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020029 active site 378806020030 phosphorylation site [posttranslational modification] 378806020031 intermolecular recognition site; other site 378806020032 dimerization interface [polypeptide binding]; other site 378806020033 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 378806020034 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 378806020035 SLBB domain; Region: SLBB; pfam10531 378806020036 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 378806020037 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 378806020038 Bacterial sugar transferase; Region: Bac_transf; cl00939 378806020039 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378806020040 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020042 active site 378806020043 phosphorylation site [posttranslational modification] 378806020044 intermolecular recognition site; other site 378806020045 dimerization interface [polypeptide binding]; other site 378806020046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806020047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 378806020048 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 378806020049 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 378806020050 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 378806020051 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 378806020052 putative NADH binding site [chemical binding]; other site 378806020053 putative active site [active] 378806020054 nudix motif; other site 378806020055 putative metal binding site [ion binding]; other site 378806020056 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 378806020057 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806020058 FeS/SAM binding site; other site 378806020059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806020060 PAS fold; Region: PAS_3; pfam08447 378806020061 putative active site [active] 378806020062 heme pocket [chemical binding]; other site 378806020063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020064 dimer interface [polypeptide binding]; other site 378806020065 phosphorylation site [posttranslational modification] 378806020066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020067 ATP binding site [chemical binding]; other site 378806020068 Mg2+ binding site [ion binding]; other site 378806020069 G-X-G motif; other site 378806020070 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020072 active site 378806020073 phosphorylation site [posttranslational modification] 378806020074 intermolecular recognition site; other site 378806020075 dimerization interface [polypeptide binding]; other site 378806020076 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 378806020077 active site 378806020078 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 378806020079 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 378806020080 tetramer interface [polypeptide binding]; other site 378806020081 heme binding pocket [chemical binding]; other site 378806020082 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378806020083 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806020084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020085 dimer interface [polypeptide binding]; other site 378806020086 phosphorylation site [posttranslational modification] 378806020087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020088 ATP binding site [chemical binding]; other site 378806020089 G-X-G motif; other site 378806020090 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 378806020091 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 378806020092 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 378806020093 SurA N-terminal domain; Region: SurA_N; pfam09312 378806020094 PPIC-type PPIASE domain; Region: Rotamase; cl08278 378806020095 SurA N-terminal domain; Region: SurA_N; pfam09312 378806020096 PPIC-type PPIASE domain; Region: Rotamase; cl08278 378806020097 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 378806020098 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 378806020099 FAD binding domain; Region: FAD_binding_4; pfam01565 378806020100 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 378806020101 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 378806020102 conserved cys residue [active] 378806020103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806020104 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378806020105 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806020106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806020107 DNA-binding site [nucleotide binding]; DNA binding site 378806020108 EamA-like transporter family; Region: EamA; cl01037 378806020109 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806020110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378806020111 active site 378806020112 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 378806020113 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806020114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806020115 DNA-binding site [nucleotide binding]; DNA binding site 378806020116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020117 active site 378806020118 ATP binding site [chemical binding]; other site 378806020119 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806020120 substrate binding site [chemical binding]; other site 378806020121 activation loop (A-loop); other site 378806020122 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806020123 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 378806020124 amidase catalytic site [active] 378806020125 Zn binding residues [ion binding]; other site 378806020126 substrate binding site [chemical binding]; other site 378806020127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 378806020128 Chitin binding domain; Region: Chitin_bind_3; cl03871 378806020129 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 378806020130 active site 378806020131 substrate binding site [chemical binding]; other site 378806020132 Mg2+ binding site [ion binding]; other site 378806020133 potassium uptake protein; Region: kup; TIGR00794 378806020134 K+ potassium transporter; Region: K_trans; cl01227 378806020135 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378806020136 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806020137 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 378806020138 DNA binding residues [nucleotide binding] 378806020139 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 378806020140 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 378806020141 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806020142 activation loop (A-loop); other site 378806020143 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 378806020144 metal ion-dependent adhesion site (MIDAS); other site 378806020145 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806020146 adenylosuccinate synthetase; Provisional; Region: PRK13786 378806020147 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806020148 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806020149 phosphopeptide binding site; other site 378806020150 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 378806020151 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 378806020152 substrate binding pocket [chemical binding]; other site 378806020153 chain length determination region; other site 378806020154 substrate-Mg2+ binding site; other site 378806020155 catalytic residues [active] 378806020156 aspartate-rich region 1; other site 378806020157 active site lid residues [active] 378806020158 aspartate-rich region 2; other site 378806020159 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 378806020160 putative oxidoreductase; Provisional; Region: PRK13984 378806020161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806020162 Uncharacterized conserved protein [Function unknown]; Region: COG3349 378806020163 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806020164 active site 378806020165 ATP binding site [chemical binding]; other site 378806020166 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806020167 substrate binding site [chemical binding]; other site 378806020168 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806020169 substrate binding site [chemical binding]; other site 378806020170 activation loop (A-loop); other site 378806020171 activation loop (A-loop); other site 378806020172 Predicted ATPase [General function prediction only]; Region: COG3899 378806020173 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806020174 Walker A/P-loop; other site 378806020175 ATP binding site [chemical binding]; other site 378806020176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 378806020177 S-adenosylmethionine binding site [chemical binding]; other site 378806020178 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 378806020179 active site 378806020180 Protein kinase domain; Region: Pkinase; pfam00069 378806020181 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020182 active site 378806020183 ATP binding site [chemical binding]; other site 378806020184 substrate binding site [chemical binding]; other site 378806020185 activation loop (A-loop); other site 378806020186 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 378806020187 putative active site [active] 378806020188 catalytic site [active] 378806020189 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 378806020190 putative active site [active] 378806020191 catalytic site [active] 378806020192 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 378806020193 classical (c) SDRs; Region: SDR_c; cd05233 378806020194 NAD(P) binding site [chemical binding]; other site 378806020195 active site 378806020196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020197 dimer interface [polypeptide binding]; other site 378806020198 phosphorylation site [posttranslational modification] 378806020199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020200 ATP binding site [chemical binding]; other site 378806020201 Mg2+ binding site [ion binding]; other site 378806020202 G-X-G motif; other site 378806020203 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020205 active site 378806020206 phosphorylation site [posttranslational modification] 378806020207 intermolecular recognition site; other site 378806020208 dimerization interface [polypeptide binding]; other site 378806020209 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806020210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020211 dimer interface [polypeptide binding]; other site 378806020212 phosphorylation site [posttranslational modification] 378806020213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020214 ATP binding site [chemical binding]; other site 378806020215 Mg2+ binding site [ion binding]; other site 378806020216 G-X-G motif; other site 378806020217 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020219 active site 378806020220 phosphorylation site [posttranslational modification] 378806020221 intermolecular recognition site; other site 378806020222 dimerization interface [polypeptide binding]; other site 378806020223 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806020224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806020225 DNA-binding site [nucleotide binding]; DNA binding site 378806020226 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806020227 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 378806020228 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020229 active site 378806020230 ATP binding site [chemical binding]; other site 378806020231 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806020232 substrate binding site [chemical binding]; other site 378806020233 activation loop (A-loop); other site 378806020234 Predicted ATPase [General function prediction only]; Region: COG3899 378806020235 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806020236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020237 active site 378806020238 phosphorylation site [posttranslational modification] 378806020239 intermolecular recognition site; other site 378806020240 dimerization interface [polypeptide binding]; other site 378806020241 sensory histidine kinase AtoS; Provisional; Region: PRK11360 378806020242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020243 ATP binding site [chemical binding]; other site 378806020244 Mg2+ binding site [ion binding]; other site 378806020245 G-X-G motif; other site 378806020246 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020248 active site 378806020249 phosphorylation site [posttranslational modification] 378806020250 intermolecular recognition site; other site 378806020251 dimerization interface [polypeptide binding]; other site 378806020252 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020254 active site 378806020255 phosphorylation site [posttranslational modification] 378806020256 intermolecular recognition site; other site 378806020257 dimerization interface [polypeptide binding]; other site 378806020258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020259 dimer interface [polypeptide binding]; other site 378806020260 phosphorylation site [posttranslational modification] 378806020261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020262 ATP binding site [chemical binding]; other site 378806020263 Mg2+ binding site [ion binding]; other site 378806020264 G-X-G motif; other site 378806020265 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806020266 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020268 active site 378806020269 phosphorylation site [posttranslational modification] 378806020270 intermolecular recognition site; other site 378806020271 dimerization interface [polypeptide binding]; other site 378806020272 Protein of unknown function DUF72; Region: DUF72; cl00777 378806020273 CARDB; Region: CARDB; pfam07705 378806020274 CARDB; Region: CARDB; pfam07705 378806020275 CARDB; Region: CARDB; pfam07705 378806020276 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 378806020277 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806020278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806020279 Cation efflux family; Region: Cation_efflux; cl00316 378806020280 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 378806020281 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 378806020282 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 378806020283 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 378806020284 active site 378806020285 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 378806020286 GtrA-like protein; Region: GtrA; cl00971 378806020287 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 378806020288 active site 378806020289 catalytic residues [active] 378806020290 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020291 active site 378806020292 ATP binding site [chemical binding]; other site 378806020293 substrate binding site [chemical binding]; other site 378806020294 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806020295 substrate binding site [chemical binding]; other site 378806020296 activation loop (A-loop); other site 378806020297 activation loop (A-loop); other site 378806020298 Predicted ATPase [General function prediction only]; Region: COG3899 378806020299 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806020300 GAF domain; Region: GAF; cl00853 378806020301 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 378806020302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020303 ATP binding site [chemical binding]; other site 378806020304 Mg2+ binding site [ion binding]; other site 378806020305 G-X-G motif; other site 378806020306 OsmC-like protein; Region: OsmC; cl00767 378806020307 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020308 active site 378806020309 ATP binding site [chemical binding]; other site 378806020310 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806020311 substrate binding site [chemical binding]; other site 378806020312 activation loop (A-loop); other site 378806020313 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020314 active site 378806020315 ATP binding site [chemical binding]; other site 378806020316 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806020317 substrate binding site [chemical binding]; other site 378806020318 activation loop (A-loop); other site 378806020319 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 378806020320 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 378806020321 Sulfatase; Region: Sulfatase; cl10460 378806020322 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 378806020323 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 378806020324 Predicted outer membrane protein [Function unknown]; Region: COG3652 378806020325 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 378806020326 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 378806020327 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 378806020328 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020329 active site 378806020330 ATP binding site [chemical binding]; other site 378806020331 substrate binding site [chemical binding]; other site 378806020332 activation loop (A-loop); other site 378806020333 Protein kinase domain; Region: Pkinase; pfam00069 378806020334 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020335 active site 378806020336 ATP binding site [chemical binding]; other site 378806020337 substrate binding site [chemical binding]; other site 378806020338 activation loop (A-loop); other site 378806020339 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806020340 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 378806020341 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 378806020342 active site 378806020343 Zn binding site [ion binding]; other site 378806020344 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 378806020345 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 378806020346 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378806020347 active site 378806020348 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 378806020349 Sphingolipid Delta4-desaturase (DES); Region: Lipid_DES; pfam08557 378806020350 sphingolipid delta-4 desaturase; Region: PLN02579 378806020351 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 378806020352 putative di-iron ligands [ion binding]; other site 378806020353 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 378806020354 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 378806020355 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 378806020356 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806020357 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 378806020358 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806020359 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378806020360 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 378806020361 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 378806020362 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 378806020363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020364 active site 378806020365 phosphorylation site [posttranslational modification] 378806020366 intermolecular recognition site; other site 378806020367 dimerization interface [polypeptide binding]; other site 378806020368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806020369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806020370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020371 ATP binding site [chemical binding]; other site 378806020372 Mg2+ binding site [ion binding]; other site 378806020373 G-X-G motif; other site 378806020374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020375 active site 378806020376 phosphorylation site [posttranslational modification] 378806020377 intermolecular recognition site; other site 378806020378 dimerization interface [polypeptide binding]; other site 378806020379 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 378806020380 GAF domain; Region: GAF; cl00853 378806020381 Phytochrome region; Region: PHY; pfam00360 378806020382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020383 dimer interface [polypeptide binding]; other site 378806020384 phosphorylation site [posttranslational modification] 378806020385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020386 ATP binding site [chemical binding]; other site 378806020387 Mg2+ binding site [ion binding]; other site 378806020388 G-X-G motif; other site 378806020389 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020391 active site 378806020392 phosphorylation site [posttranslational modification] 378806020393 intermolecular recognition site; other site 378806020394 dimerization interface [polypeptide binding]; other site 378806020395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806020396 PAS fold; Region: PAS_3; pfam08447 378806020397 putative active site [active] 378806020398 heme pocket [chemical binding]; other site 378806020399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020400 dimer interface [polypeptide binding]; other site 378806020401 phosphorylation site [posttranslational modification] 378806020402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020403 ATP binding site [chemical binding]; other site 378806020404 Mg2+ binding site [ion binding]; other site 378806020405 G-X-G motif; other site 378806020406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020407 active site 378806020408 phosphorylation site [posttranslational modification] 378806020409 intermolecular recognition site; other site 378806020410 dimerization interface [polypeptide binding]; other site 378806020411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020412 dimer interface [polypeptide binding]; other site 378806020413 phosphorylation site [posttranslational modification] 378806020414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020415 ATP binding site [chemical binding]; other site 378806020416 Mg2+ binding site [ion binding]; other site 378806020417 G-X-G motif; other site 378806020418 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 378806020419 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 378806020420 active site 378806020421 catalytic tetrad [active] 378806020422 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 378806020423 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 378806020424 ligand-binding site [chemical binding]; other site 378806020425 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 378806020426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806020427 Walker A/P-loop; other site 378806020428 ATP binding site [chemical binding]; other site 378806020429 Q-loop/lid; other site 378806020430 ABC transporter signature motif; other site 378806020431 Walker B; other site 378806020432 D-loop; other site 378806020433 H-loop/switch region; other site 378806020434 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 378806020435 metal binding triad [ion binding]; metal-binding site 378806020436 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 378806020437 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 378806020438 active site 378806020439 metal binding site [ion binding]; metal-binding site 378806020440 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 378806020441 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 378806020442 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 378806020443 Phosphopantetheine attachment site; Region: PP-binding; cl09936 378806020444 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 378806020445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806020446 FeS/SAM binding site; other site 378806020447 HemN C-terminal region; Region: HemN_C; pfam06969 378806020448 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 378806020449 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 378806020450 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 378806020451 NADP binding site [chemical binding]; other site 378806020452 substrate binding site [chemical binding]; other site 378806020453 active site 378806020454 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 378806020455 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 378806020456 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 378806020457 metal binding triad [ion binding]; metal-binding site 378806020458 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 378806020459 classical (c) SDRs; Region: SDR_c; cd05233 378806020460 NAD(P) binding site [chemical binding]; other site 378806020461 active site 378806020462 AAA-like domain; Region: AAA_10; pfam12846 378806020463 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 378806020464 putative active site [active] 378806020465 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 378806020466 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 378806020467 Imelysin; Region: Peptidase_M75; cl09159 378806020468 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 378806020469 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 378806020470 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 378806020471 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 378806020472 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 378806020473 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 378806020474 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 378806020475 N-terminal plug; other site 378806020476 ligand-binding site [chemical binding]; other site 378806020477 phenylhydantoinase; Validated; Region: PRK08323 378806020478 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 378806020479 tetramer interface [polypeptide binding]; other site 378806020480 active site 378806020481 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 378806020482 Predicted amidohydrolase [General function prediction only]; Region: COG0388 378806020483 active site 378806020484 catalytic triad [active] 378806020485 dimer interface [polypeptide binding]; other site 378806020486 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 378806020487 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806020488 inhibitor-cofactor binding pocket; inhibition site 378806020489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806020490 catalytic residue [active] 378806020491 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 378806020492 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 378806020493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806020494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 378806020495 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 378806020496 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 378806020497 homodimer interface [polypeptide binding]; other site 378806020498 active site 378806020499 FMN binding site [chemical binding]; other site 378806020500 substrate binding site [chemical binding]; other site 378806020501 Sodium:solute symporter family; Region: SSF; cl00456 378806020502 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 378806020503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806020504 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 378806020505 active site 378806020506 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 378806020507 catalytic residues [active] 378806020508 dimer interface [polypeptide binding]; other site 378806020509 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 378806020510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806020511 Walker A motif; other site 378806020512 ATP binding site [chemical binding]; other site 378806020513 Walker B motif; other site 378806020514 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 378806020515 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806020516 putative active site [active] 378806020517 putative metal binding site [ion binding]; other site 378806020518 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 378806020519 classical (c) SDRs; Region: SDR_c; cd05233 378806020520 NAD(P) binding site [chemical binding]; other site 378806020521 active site 378806020522 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378806020523 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378806020524 calcium binding site 2 [ion binding]; other site 378806020525 active site 378806020526 catalytic triad [active] 378806020527 calcium binding site 1 [ion binding]; other site 378806020528 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806020529 putative sugar binding sites [chemical binding]; other site 378806020530 Q-X-W motif; other site 378806020531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378806020532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 378806020533 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 378806020534 putative effector binding pocket; other site 378806020535 putative dimerization interface [polypeptide binding]; other site 378806020536 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 378806020537 NADP binding site [chemical binding]; other site 378806020538 active site 378806020539 steroid binding site; other site 378806020540 GTP-binding protein YchF; Reviewed; Region: PRK09601 378806020541 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 378806020542 G1 box; other site 378806020543 GTP/Mg2+ binding site [chemical binding]; other site 378806020544 Switch I region; other site 378806020545 G2 box; other site 378806020546 Switch II region; other site 378806020547 G3 box; other site 378806020548 G4 box; other site 378806020549 G5 box; other site 378806020550 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 378806020551 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 378806020552 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 378806020553 ATP synthase A chain; Region: ATP-synt_A; cl00413 378806020554 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 378806020555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 378806020556 GAF domain; Region: GAF; cl00853 378806020557 GAF domain; Region: GAF; cl00853 378806020558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378806020559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020560 dimer interface [polypeptide binding]; other site 378806020561 phosphorylation site [posttranslational modification] 378806020562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020563 ATP binding site [chemical binding]; other site 378806020564 Mg2+ binding site [ion binding]; other site 378806020565 G-X-G motif; other site 378806020566 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 378806020567 Domain of unknown function DUF28; Region: DUF28; cl00361 378806020568 PEGA domain; Region: PEGA; pfam08308 378806020569 Domain of unknown function DUF37; Region: DUF37; cl00506 378806020570 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 378806020571 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 378806020572 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 378806020573 Helix-turn-helix domain; Region: HTH_18; pfam12833 378806020574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378806020575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806020576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378806020577 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 378806020578 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806020579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806020580 DNA-binding site [nucleotide binding]; DNA binding site 378806020581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378806020582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020583 dimer interface [polypeptide binding]; other site 378806020584 phosphorylation site [posttranslational modification] 378806020585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020586 ATP binding site [chemical binding]; other site 378806020587 Mg2+ binding site [ion binding]; other site 378806020588 G-X-G motif; other site 378806020589 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806020590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020591 active site 378806020592 phosphorylation site [posttranslational modification] 378806020593 intermolecular recognition site; other site 378806020594 dimerization interface [polypeptide binding]; other site 378806020595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806020596 Walker A motif; other site 378806020597 ATP binding site [chemical binding]; other site 378806020598 Walker B motif; other site 378806020599 arginine finger; other site 378806020600 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 378806020601 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 378806020602 Protein kinase domain; Region: Pkinase; pfam00069 378806020603 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020604 active site 378806020605 ATP binding site [chemical binding]; other site 378806020606 substrate binding site [chemical binding]; other site 378806020607 activation loop (A-loop); other site 378806020608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806020609 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 378806020610 Walker A motif; other site 378806020611 ATP binding site [chemical binding]; other site 378806020612 Walker B motif; other site 378806020613 arginine finger; other site 378806020614 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806020615 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 378806020616 B12 binding site [chemical binding]; other site 378806020617 Radical SAM; Region: Elp3; smart00729 378806020618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 378806020619 FeS/SAM binding site; other site 378806020620 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806020621 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020622 active site 378806020623 ATP binding site [chemical binding]; other site 378806020624 substrate binding site [chemical binding]; other site 378806020625 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806020626 substrate binding site [chemical binding]; other site 378806020627 activation loop (A-loop); other site 378806020628 activation loop (A-loop); other site 378806020629 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 378806020630 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806020631 inhibitor-cofactor binding pocket; inhibition site 378806020632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806020633 catalytic residue [active] 378806020634 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 378806020635 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 378806020636 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 378806020637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 378806020638 Transposase; Region: DDE_Tnp_ISL3; pfam01610 378806020639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 378806020640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 378806020641 active site 378806020642 motif I; other site 378806020643 motif II; other site 378806020644 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 378806020645 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 378806020646 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 378806020647 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 378806020648 putative catalytic site [active] 378806020649 putative metal binding site [ion binding]; other site 378806020650 putative phosphate binding site [ion binding]; other site 378806020651 Protein of unknown function DUF82; Region: DUF82; pfam01927 378806020652 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 378806020653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 378806020654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 378806020655 DNA binding residues [nucleotide binding] 378806020656 dimerization interface [polypeptide binding]; other site 378806020657 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 378806020658 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 378806020659 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806020660 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378806020661 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806020662 phosphopeptide binding site; other site 378806020663 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 378806020664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806020665 Walker A motif; other site 378806020666 ATP binding site [chemical binding]; other site 378806020667 Walker B motif; other site 378806020668 arginine finger; other site 378806020669 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 378806020670 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 378806020671 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806020672 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 378806020673 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378806020674 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 378806020675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 378806020676 putative active site [active] 378806020677 heme pocket [chemical binding]; other site 378806020678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 378806020679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020680 ATP binding site [chemical binding]; other site 378806020681 Mg2+ binding site [ion binding]; other site 378806020682 G-X-G motif; other site 378806020683 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 378806020684 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 378806020685 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806020686 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806020687 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 378806020688 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 378806020689 amidase catalytic site [active] 378806020690 Zn binding residues [ion binding]; other site 378806020691 substrate binding site [chemical binding]; other site 378806020692 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 378806020693 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806020694 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 378806020695 putative active site [active] 378806020696 putative metal binding site [ion binding]; other site 378806020697 Predicted ATPase [General function prediction only]; Region: COG4637 378806020698 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806020699 Walker A/P-loop; other site 378806020700 ATP binding site [chemical binding]; other site 378806020701 Q-loop/lid; other site 378806020702 ABC transporter signature motif; other site 378806020703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806020704 Q-loop/lid; other site 378806020705 ABC transporter signature motif; other site 378806020706 Walker B; other site 378806020707 D-loop; other site 378806020708 H-loop/switch region; other site 378806020709 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 378806020710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020711 dimer interface [polypeptide binding]; other site 378806020712 phosphorylation site [posttranslational modification] 378806020713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020714 ATP binding site [chemical binding]; other site 378806020715 Mg2+ binding site [ion binding]; other site 378806020716 G-X-G motif; other site 378806020717 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020719 active site 378806020720 phosphorylation site [posttranslational modification] 378806020721 intermolecular recognition site; other site 378806020722 dimerization interface [polypeptide binding]; other site 378806020723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020724 dimer interface [polypeptide binding]; other site 378806020725 phosphorylation site [posttranslational modification] 378806020726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020727 ATP binding site [chemical binding]; other site 378806020728 Mg2+ binding site [ion binding]; other site 378806020729 G-X-G motif; other site 378806020730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020731 dimer interface [polypeptide binding]; other site 378806020732 phosphorylation site [posttranslational modification] 378806020733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020734 ATP binding site [chemical binding]; other site 378806020735 Mg2+ binding site [ion binding]; other site 378806020736 G-X-G motif; other site 378806020737 Response regulator receiver domain; Region: Response_reg; pfam00072 378806020738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806020739 active site 378806020740 phosphorylation site [posttranslational modification] 378806020741 intermolecular recognition site; other site 378806020742 dimerization interface [polypeptide binding]; other site 378806020743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806020744 dimer interface [polypeptide binding]; other site 378806020745 phosphorylation site [posttranslational modification] 378806020746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806020747 ATP binding site [chemical binding]; other site 378806020748 Mg2+ binding site [ion binding]; other site 378806020749 G-X-G motif; other site 378806020750 potassium uptake protein; Region: kup; TIGR00794 378806020751 K+ potassium transporter; Region: K_trans; cl01227 378806020752 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 378806020753 heme-binding site [chemical binding]; other site 378806020754 5'-3' exonuclease; Region: 53EXOc; smart00475 378806020755 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 378806020756 active site 378806020757 metal binding site 1 [ion binding]; metal-binding site 378806020758 putative 5' ssDNA interaction site; other site 378806020759 metal binding site 3; metal-binding site 378806020760 metal binding site 2 [ion binding]; metal-binding site 378806020761 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 378806020762 putative DNA binding site [nucleotide binding]; other site 378806020763 putative metal binding site [ion binding]; other site 378806020764 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 378806020765 ligand binding site [chemical binding]; other site 378806020766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806020767 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378806020768 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 378806020769 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 378806020770 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_2; cd03330 378806020771 putative ADP-ribose binding site [chemical binding]; other site 378806020772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378806020773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378806020774 Coenzyme A transferase; Region: CoA_trans; cl00773 378806020775 Coenzyme A transferase; Region: CoA_trans; cl00773 378806020776 putative alcohol dehydrogenase; Provisional; Region: PRK13771 378806020777 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 378806020778 NAD(P) binding site [chemical binding]; other site 378806020779 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 378806020780 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 378806020781 dimer interface [polypeptide binding]; other site 378806020782 active site 378806020783 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806020784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806020785 DNA-binding site [nucleotide binding]; DNA binding site 378806020786 Predicted acetyltransferase [General function prediction only]; Region: COG3393 378806020787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806020788 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 378806020789 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 378806020790 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 378806020791 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 378806020792 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806020793 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806020794 starch binding outer membrane protein SusD; Region: SusD; cd08977 378806020795 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 378806020796 active site 378806020797 metal binding site [ion binding]; metal-binding site 378806020798 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806020799 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806020800 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806020801 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806020802 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806020803 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806020804 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 378806020805 metal binding triad [ion binding]; metal-binding site 378806020806 Archaeal ATPase; Region: Arch_ATPase; pfam01637 378806020807 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 378806020808 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 378806020809 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 378806020810 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020811 active site 378806020812 ATP binding site [chemical binding]; other site 378806020813 substrate binding site [chemical binding]; other site 378806020814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806020815 activation loop (A-loop); other site 378806020816 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806020817 structural tetrad; other site 378806020818 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 378806020819 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 378806020820 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 378806020821 structural tetrad; other site 378806020822 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 378806020823 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 378806020824 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 378806020825 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 378806020826 ATP binding site [chemical binding]; other site 378806020827 Mg++ binding site [ion binding]; other site 378806020828 motif III; other site 378806020829 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378806020830 nucleotide binding region [chemical binding]; other site 378806020831 ATP-binding site [chemical binding]; other site 378806020832 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 378806020833 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 378806020834 putative NAD(P) binding site [chemical binding]; other site 378806020835 dimer interface [polypeptide binding]; other site 378806020836 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 378806020837 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 378806020838 active site 378806020839 dimer interface [polypeptide binding]; other site 378806020840 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806020841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806020842 Walker A/P-loop; other site 378806020843 ATP binding site [chemical binding]; other site 378806020844 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806020845 VanW like protein; Region: VanW; pfam04294 378806020846 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 378806020847 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 378806020848 putative [Fe4-S4] binding site [ion binding]; other site 378806020849 putative molybdopterin cofactor binding site [chemical binding]; other site 378806020850 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 378806020851 molybdopterin cofactor binding site; other site 378806020852 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 378806020853 Cellulose binding domain; Region: CBM_2; cl02709 378806020854 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 378806020855 active site 378806020856 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 378806020857 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 378806020858 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 378806020859 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 378806020860 Ligand binding site [chemical binding]; other site 378806020861 metal binding site [ion binding]; metal-binding site 378806020862 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 378806020863 Phage Tail Collar Domain; Region: Collar; pfam07484 378806020864 Domain of unknown function DUF20; Region: UPF0118; cl00465 378806020865 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 378806020866 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378806020867 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 378806020868 amidase catalytic site [active] 378806020869 Zn binding residues [ion binding]; other site 378806020870 substrate binding site [chemical binding]; other site 378806020871 Outer membrane efflux protein; Region: OEP; pfam02321 378806020872 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 378806020873 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 378806020874 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 378806020875 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 378806020876 Malic enzyme, N-terminal domain; Region: malic; pfam00390 378806020877 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 378806020878 putative NAD(P) binding site [chemical binding]; other site 378806020879 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 378806020880 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378806020881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378806020882 ATP binding site [chemical binding]; other site 378806020883 putative Mg++ binding site [ion binding]; other site 378806020884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 378806020885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806020886 Coenzyme A binding pocket [chemical binding]; other site 378806020887 Beta-lactamase; Region: Beta-lactamase; cl01009 378806020888 Predicted transcriptional regulator [Transcription]; Region: COG5340 378806020889 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 378806020890 putative active site [active] 378806020891 putative metal binding site [ion binding]; other site 378806020892 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806020893 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 378806020894 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378806020895 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 378806020896 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 378806020897 inhibitor-cofactor binding pocket; inhibition site 378806020898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378806020899 catalytic residue [active] 378806020900 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 378806020901 FemAB family; Region: FemAB; cl11444 378806020902 Protein of unknown function, DUF482; Region: DUF482; pfam04339 378806020903 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 378806020904 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 378806020905 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 378806020906 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 378806020907 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 378806020908 putative sugar binding sites [chemical binding]; other site 378806020909 Q-X-W motif; other site 378806020910 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 378806020911 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 378806020912 calcium mediated ligand binding site; other site 378806020913 intermolecular salt bridges; other site 378806020914 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020915 Protein kinase domain; Region: Pkinase; pfam00069 378806020916 active site 378806020917 ATP binding site [chemical binding]; other site 378806020918 substrate binding site [chemical binding]; other site 378806020919 activation loop (A-loop); other site 378806020920 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 378806020921 dinuclear metal binding motif [ion binding]; other site 378806020922 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806020923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806020924 DNA-binding site [nucleotide binding]; DNA binding site 378806020925 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378806020926 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378806020927 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 378806020928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 378806020929 O-methyltransferase; Region: Methyltransf_2; pfam00891 378806020930 putative phosphoketolase; Provisional; Region: PRK05261 378806020931 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 378806020932 TPP-binding site; other site 378806020933 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 378806020934 XFP C-terminal domain; Region: XFP_C; pfam09363 378806020935 Acetokinase family; Region: Acetate_kinase; cl01029 378806020936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806020937 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 378806020938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 378806020939 active site 378806020940 phosphorylation site [posttranslational modification] 378806020941 intermolecular recognition site; other site 378806020942 dimerization interface [polypeptide binding]; other site 378806020943 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 378806020944 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 378806020945 active site 378806020946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806020947 Coenzyme A binding pocket [chemical binding]; other site 378806020948 Uncharacterized conserved protein [Function unknown]; Region: COG1572 378806020949 CARDB; Region: CARDB; pfam07705 378806020950 CARDB; Region: CARDB; pfam07705 378806020951 CARDB; Region: CARDB; pfam07705 378806020952 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 378806020953 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 378806020954 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 378806020955 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 378806020956 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 378806020957 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 378806020958 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 378806020959 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 378806020960 putative catalytic residue [active] 378806020961 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 378806020962 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 378806020963 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 378806020964 DsbD alpha interface [polypeptide binding]; other site 378806020965 catalytic residues [active] 378806020966 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 378806020967 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378806020968 metal ion-dependent adhesion site (MIDAS); other site 378806020969 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 378806020970 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 378806020971 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 378806020972 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 378806020973 Cysteine-rich domain; Region: CCG; pfam02754 378806020974 Cysteine-rich domain; Region: CCG; pfam02754 378806020975 Replication protein C N-terminal domain; Region: RP-C; pfam03428 378806020976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 378806020977 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806020978 NADP+ binding site [chemical binding]; other site 378806020979 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 378806020980 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 378806020981 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 378806020982 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 378806020983 Peptidase family M54; Region: Peptidase_M54; cl00835 378806020984 Fic family protein [Function unknown]; Region: COG3177 378806020985 Fic/DOC family; Region: Fic; cl00960 378806020986 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378806020987 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 378806020988 active site 378806020989 metal binding site [ion binding]; metal-binding site 378806020990 Protein kinase domain; Region: Pkinase; pfam00069 378806020991 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806020992 active site 378806020993 ATP binding site [chemical binding]; other site 378806020994 substrate binding site [chemical binding]; other site 378806020995 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806020996 substrate binding site [chemical binding]; other site 378806020997 activation loop (A-loop); other site 378806020998 activation loop (A-loop); other site 378806020999 Fatty acid desaturase; Region: FA_desaturase; pfam00487 378806021000 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 378806021001 putative di-iron ligands [ion binding]; other site 378806021002 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 378806021003 DNA-binding site [nucleotide binding]; DNA binding site 378806021004 RNA-binding motif; other site 378806021005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806021006 binding surface 378806021007 TPR motif; other site 378806021008 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806021009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806021010 TPR motif; other site 378806021011 binding surface 378806021012 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 378806021013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806021014 active site 378806021015 ATP binding site [chemical binding]; other site 378806021016 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806021017 substrate binding site [chemical binding]; other site 378806021018 activation loop (A-loop); other site 378806021019 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 378806021020 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 378806021021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378806021022 non-specific DNA binding site [nucleotide binding]; other site 378806021023 salt bridge; other site 378806021024 sequence-specific DNA binding site [nucleotide binding]; other site 378806021025 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 378806021026 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 378806021027 trimer interface [polypeptide binding]; other site 378806021028 active site 378806021029 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 378806021030 catalytic site [active] 378806021031 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 378806021032 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 378806021033 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 378806021034 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 378806021035 homodimer interface [polypeptide binding]; other site 378806021036 glycosyltransferase, MGT family; Region: MGT; TIGR01426 378806021037 active site 378806021038 TDP-binding site; other site 378806021039 acceptor substrate-binding pocket; other site 378806021040 Histidine kinase; Region: His_kinase; pfam06580 378806021041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806021042 ATP binding site [chemical binding]; other site 378806021043 Mg2+ binding site [ion binding]; other site 378806021044 G-X-G motif; other site 378806021045 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 378806021046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 378806021047 active site 378806021048 phosphorylation site [posttranslational modification] 378806021049 intermolecular recognition site; other site 378806021050 dimerization interface [polypeptide binding]; other site 378806021051 LytTr DNA-binding domain; Region: LytTR; cl04498 378806021052 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 378806021053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806021054 Walker A motif; other site 378806021055 ATP binding site [chemical binding]; other site 378806021056 Walker B motif; other site 378806021057 arginine finger; other site 378806021058 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806021059 active site 378806021060 ATP binding site [chemical binding]; other site 378806021061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806021062 substrate binding site [chemical binding]; other site 378806021063 activation loop (A-loop); other site 378806021064 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 378806021065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378806021066 Coenzyme A binding pocket [chemical binding]; other site 378806021067 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806021068 active site 378806021069 ATP binding site [chemical binding]; other site 378806021070 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806021071 substrate binding site [chemical binding]; other site 378806021072 activation loop (A-loop); other site 378806021073 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806021074 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 378806021075 Gram-negative bacterial tonB protein; Region: TonB; cl10048 378806021076 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 378806021077 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 378806021078 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 378806021079 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 378806021080 ABC-2 type transporter; Region: ABC2_membrane; cl11417 378806021081 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 378806021082 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 378806021083 Walker A/P-loop; other site 378806021084 ATP binding site [chemical binding]; other site 378806021085 Q-loop/lid; other site 378806021086 ABC transporter signature motif; other site 378806021087 Walker B; other site 378806021088 D-loop; other site 378806021089 H-loop/switch region; other site 378806021090 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 378806021091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 378806021092 dimer interface [polypeptide binding]; other site 378806021093 phosphorylation site [posttranslational modification] 378806021094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378806021095 ATP binding site [chemical binding]; other site 378806021096 Mg2+ binding site [ion binding]; other site 378806021097 G-X-G motif; other site 378806021098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 378806021099 FAD binding domain; Region: FAD_binding_4; pfam01565 378806021100 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 378806021101 RES domain; Region: RES; cl02411 378806021102 TIGR03440 family protein; Region: unchr_TIGR03440 378806021103 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 378806021104 probable methyltransferase; Region: TIGR03438 378806021105 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 378806021106 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 378806021107 ParB-like partition proteins; Region: parB_part; TIGR00180 378806021108 ParB-like nuclease domain; Region: ParBc; cl02129 378806021109 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 378806021110 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 378806021111 P-loop; other site 378806021112 Magnesium ion binding site [ion binding]; other site 378806021113 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 378806021114 Magnesium ion binding site [ion binding]; other site 378806021115 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 378806021116 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806021117 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806021118 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806021119 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806021120 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806021121 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 378806021122 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 378806021123 GAF domain; Region: GAF; cl00853 378806021124 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 378806021125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 378806021126 Walker A motif; other site 378806021127 ATP binding site [chemical binding]; other site 378806021128 Walker B motif; other site 378806021129 arginine finger; other site 378806021130 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806021131 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806021132 active site 378806021133 ATP binding site [chemical binding]; other site 378806021134 substrate binding site [chemical binding]; other site 378806021135 activation loop (A-loop); other site 378806021136 PEGA domain; Region: PEGA; pfam08308 378806021137 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 378806021138 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 378806021139 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 378806021140 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 378806021141 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 378806021142 Peptidase family S48; Region: Peptidase_S48; cl11616 378806021143 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378806021144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378806021145 DNA-binding site [nucleotide binding]; DNA binding site 378806021146 FCD domain; Region: FCD; cl11656 378806021147 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 378806021148 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 378806021149 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 378806021150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 378806021151 TPR motif; other site 378806021152 binding surface 378806021153 YCII-related domain; Region: YCII; cl00999 378806021154 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 378806021155 putative peptidoglycan binding site; other site 378806021156 Protein kinase domain; Region: Pkinase; pfam00069 378806021157 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806021158 active site 378806021159 ATP binding site [chemical binding]; other site 378806021160 substrate binding site [chemical binding]; other site 378806021161 activation loop (A-loop); other site 378806021162 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378806021163 phosphopeptide binding site; other site 378806021164 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378806021165 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 378806021166 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 378806021167 putative dimerization interface [polypeptide binding]; other site 378806021168 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 378806021169 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 378806021170 hydrophobic ligand binding site; other site 378806021171 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378806021172 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 378806021173 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378806021174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 378806021175 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 378806021176 Phage Tail Collar Domain; Region: Collar; pfam07484 378806021177 YCII-related domain; Region: YCII; cl00999 378806021178 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 378806021179 Moco binding site; other site 378806021180 metal coordination site [ion binding]; other site 378806021181 dimerization interface [polypeptide binding]; other site 378806021182 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378806021183 active site 378806021184 ATP binding site [chemical binding]; other site 378806021185 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378806021186 substrate binding site [chemical binding]; other site 378806021187 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378806021188 substrate binding site [chemical binding]; other site 378806021189 activation loop (A-loop); other site 378806021190 activation loop (A-loop); other site 378806021191 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806021192 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378806021193 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806021194 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378806021195 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378806021196 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 378806021197 oligomer interface [polypeptide binding]; other site 378806021198 tandem repeat interface [polypeptide binding]; other site 378806021199 active site residues [active] 378806021200 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 378806021201 tandem repeat interface [polypeptide binding]; other site 378806021202 oligomer interface [polypeptide binding]; other site 378806021203 active site residues [active] 378806021204 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 378806021205 TadE-like protein; Region: TadE; pfam07811 378806021206 Cysteine dioxygenase type I; Region: CDO_I; cl02350 378806021207 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 378806021208 putative active site [active] 378806021209 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 378806021210 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 378806021211 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 378806021212 G1 box; other site 378806021213 GTP/Mg2+ binding site [chemical binding]; other site 378806021214 Switch I region; other site 378806021215 G2 box; other site 378806021216 Switch II region; other site 378806021217 G3 box; other site 378806021218 G4 box; other site 378806021219 G5 box; other site 378806021220 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 378806021221 G-X-X-G motif; other site 378806021222 membrane protein insertase; Provisional; Region: PRK01318 378806021223 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 378806021224 Domain of unknown function DUF37; Region: DUF37; cl00506 378806021225 Ribonuclease P; Region: Ribonuclease_P; cl00457 378806021226 Ribosomal protein L34; Region: Ribosomal_L34; cl00370